FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0577, 1041 aa 1>>>pF1KA0577 1041 - 1041 aa - 1041 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.9497+/-0.000612; mu= -4.6306+/- 0.038 mean_var=395.1916+/-79.853, 0's: 0 Z-trim(116.3): 104 B-trim: 803 in 1/55 Lambda= 0.064516 statistics sampled from 27352 (27453) to 27352 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.322), width: 16 Scan time: 16.600 The best scores are: opt bits E(85289) NP_003578 (OMIM: 603405) putative pre-mRNA-splicin (1041) 6778 646.7 1.9e-184 NP_001157711 (OMIM: 603405) putative pre-mRNA-spli ( 981) 6323 604.4 1e-171 XP_011513240 (OMIM: 603405) PREDICTED: putative pr ( 742) 4866 468.6 5.6e-131 XP_011513241 (OMIM: 603405) PREDICTED: putative pr ( 742) 4866 468.6 5.6e-131 XP_011513242 (OMIM: 603405) PREDICTED: putative pr ( 560) 3474 339.0 4.6e-92 XP_011513243 (OMIM: 603405) PREDICTED: putative pr ( 524) 3464 338.0 8.3e-92 NP_001309145 (OMIM: 600396) ATP-dependent RNA heli ( 945) 2590 256.9 3.9e-67 NP_001309146 (OMIM: 600396) ATP-dependent RNA heli (1129) 2590 257.0 4.4e-67 NP_001309150 (OMIM: 600396) ATP-dependent RNA heli (1218) 2590 257.0 4.7e-67 NP_004932 (OMIM: 600396) ATP-dependent RNA helicas (1220) 2590 257.0 4.7e-67 NP_001309148 (OMIM: 600396) ATP-dependent RNA heli (1169) 2446 243.6 4.9e-63 NP_001309149 (OMIM: 600396) ATP-dependent RNA heli (1152) 2422 241.3 2.3e-62 NP_001309147 (OMIM: 600396) ATP-dependent RNA heli (1179) 2422 241.4 2.3e-62 NP_001289552 (OMIM: 600396) ATP-dependent RNA heli (1181) 2422 241.4 2.3e-62 NP_054722 (OMIM: 605584) pre-mRNA-splicing factor (1227) 2331 232.9 8.5e-60 XP_011521786 (OMIM: 605584) PREDICTED: pre-mRNA-sp (1227) 2331 232.9 8.5e-60 XP_011521787 (OMIM: 605584) PREDICTED: pre-mRNA-sp (1227) 2331 232.9 8.5e-60 XP_016879402 (OMIM: 605584) PREDICTED: pre-mRNA-sp (1192) 2325 232.3 1.2e-59 XP_005256326 (OMIM: 605584) PREDICTED: pre-mRNA-sp (1192) 2325 232.3 1.2e-59 NP_001349 (OMIM: 603403) pre-mRNA-splicing factor ( 795) 2076 209.0 8.7e-53 NP_064547 (OMIM: 614405) putative ATP-dependent RN ( 707) 1852 188.1 1.5e-46 NP_001186628 (OMIM: 614405) putative ATP-dependent ( 534) 1462 151.7 1e-35 XP_011525852 (OMIM: 615475) PREDICTED: probable AT (1143) 1131 121.2 3.4e-26 XP_011525853 (OMIM: 615475) PREDICTED: probable AT (1143) 1131 121.2 3.4e-26 XP_005259500 (OMIM: 615475) PREDICTED: probable AT (1143) 1131 121.2 3.4e-26 NP_055496 (OMIM: 615475) probable ATP-dependent RN (1143) 1131 121.2 3.4e-26 XP_016871894 (OMIM: 607960) PREDICTED: putative pr ( 743) 1096 117.7 2.4e-25 XP_016871893 (OMIM: 607960) PREDICTED: putative pr ( 743) 1096 117.7 2.4e-25 NP_060650 (OMIM: 607960) putative pre-mRNA-splicin ( 743) 1096 117.7 2.4e-25 XP_016880572 (OMIM: 607570) PREDICTED: probable AT ( 640) 876 97.2 3.1e-19 XP_016880571 (OMIM: 607570) PREDICTED: probable AT ( 640) 876 97.2 3.1e-19 XP_011523556 (OMIM: 607570) PREDICTED: probable AT ( 680) 876 97.2 3.3e-19 NP_001159773 (OMIM: 607570) probable ATP-dependent ( 702) 876 97.2 3.3e-19 XP_016880569 (OMIM: 607570) PREDICTED: probable AT ( 723) 876 97.2 3.4e-19 NP_078888 (OMIM: 607570) probable ATP-dependent RN ( 779) 876 97.3 3.6e-19 XP_011523555 (OMIM: 607570) PREDICTED: probable AT ( 718) 660 77.1 3.8e-13 XP_016880366 (OMIM: 614405) PREDICTED: putative AT ( 279) 646 75.4 4.8e-13 NP_065916 (OMIM: 612767) ATP-dependent RNA helicas (1008) 644 75.8 1.4e-12 XP_016880570 (OMIM: 607570) PREDICTED: probable AT ( 653) 597 71.2 2.1e-11 XP_006722146 (OMIM: 607570) PREDICTED: probable AT ( 752) 597 71.3 2.3e-11 NP_001107869 (OMIM: 612767) ATP-dependent RNA heli ( 994) 574 69.3 1.2e-10 XP_016865224 (OMIM: 616530) PREDICTED: probable AT ( 971) 545 66.6 7.9e-10 NP_001332905 (OMIM: 616530) probable ATP-dependent (1130) 545 66.6 8.8e-10 XP_016865222 (OMIM: 616530) PREDICTED: probable AT (1139) 545 66.6 8.9e-10 XP_011541888 (OMIM: 616530) PREDICTED: probable AT (1162) 545 66.6 9e-10 NP_001332904 (OMIM: 616530) probable ATP-dependent (1268) 545 66.7 9.5e-10 XP_016865220 (OMIM: 616530) PREDICTED: probable AT (1277) 545 66.7 9.6e-10 XP_011541884 (OMIM: 616530) PREDICTED: probable AT (1406) 545 66.7 1e-09 NP_073739 (OMIM: 616530) probable ATP-dependent RN (1430) 545 66.7 1e-09 XP_016865219 (OMIM: 616530) PREDICTED: probable AT (1430) 545 66.7 1e-09 >>NP_003578 (OMIM: 603405) putative pre-mRNA-splicing fa (1041 aa) initn: 6778 init1: 6778 opt: 6778 Z-score: 3432.5 bits: 646.7 E(85289): 1.9e-184 Smith-Waterman score: 6778; 100.0% identity (100.0% similar) in 1041 aa overlap (1-1041:1-1041) 10 20 30 40 50 60 pF1KA0 MATPAGLERWVQDELHSVLGLSERHVAQFLIGTAQRCTSAEEFVQRLRDTDTLDLSGPAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MATPAGLERWVQDELHSVLGLSERHVAQFLIGTAQRCTSAEEFVQRLRDTDTLDLSGPAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 DFALRLWNKVPRKAVVEKPARAAEREARALLEKNRSYRLLEDSEESSEETVSRAGSSLQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DFALRLWNKVPRKAVVEKPARAAEREARALLEKNRSYRLLEDSEESSEETVSRAGSSLQK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 KRKKRKHLRKKREEEEEEEASEKGKKKTGGSKQQTEKPESEDEWERTERERLQDLEERDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KRKKRKHLRKKREEEEEEEASEKGKKKTGGSKQQTEKPESEDEWERTERERLQDLEERDA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 FAERVRQRDKDRTRNVLERSDKKAYEEAQKRLKMAEEDRKAMVPELRKKSRREYLAKRER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FAERVRQRDKDRTRNVLERSDKKAYEEAQKRLKMAEEDRKAMVPELRKKSRREYLAKRER 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 EKLEDLEAELADEEFLFGDVELSRHERQELKYKRRVRDLAREYRAAGEQEKLEATNRYHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EKLEDLEAELADEEFLFGDVELSRHERQELKYKRRVRDLAREYRAAGEQEKLEATNRYHM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 PKETRGQPARAVDLVEEESGAPGEEQRRWEEARLGAASLKFGARDAASQEPKYQLVLEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PKETRGQPARAVDLVEEESGAPGEEQRRWEEARLGAASLKFGARDAASQEPKYQLVLEEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 ETIEFVRATQLQGDEEPSAPPTSTQAQQKESIQAVRRSLPVFPFREELLAAIANHQVLII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ETIEFVRATQLQGDEEPSAPPTSTQAQQKESIQAVRRSLPVFPFREELLAAIANHQVLII 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 EGETGSGKTTQIPQYLFEEGYTNKGMKIACTQPRRVAAMSVAARVAREMGVKLGNEVGYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EGETGSGKTTQIPQYLFEEGYTNKGMKIACTQPRRVAAMSVAARVAREMGVKLGNEVGYS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 IRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERTLHTDILFGLIKDVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 IRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERTLHTDILFGLIKDVA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 RFRPELKVLVASATMDTARFSTFFDDAPVFRIPGRRFPVDIFYTKAPEADYLEACVVSVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RFRPELKVLVASATMDTARFSTFFDDAPVFRIPGRRFPVDIFYTKAPEADYLEACVVSVL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 QIHVTQPPGDILVFLTGQEEIEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QIHVTQPPGDILVFLTGQEEIEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIF 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 QPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASAN 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 QRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDF 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 LDPPPYETLLLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LDPPPYETLLLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEI 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 LTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAESGYSSQWCYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAESGYSSQWCYE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 NFVQFRSMRRARDVREQLEGLLERVEVGLSSCQGDYIRVRKAITAGYFYHTARLTRSGYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NFVQFRSMRRARDVREQLEGLLERVEVGLSSCQGDYIRVRKAITAGYFYHTARLTRSGYR 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 TVKQQQTVFIHPNSSLFEQQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHYYKAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TVKQQQTVFIHPNSSLFEQQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHYYKAKE 970 980 990 1000 1010 1020 1030 1040 pF1KA0 LEDPHAKKMPKKIGKTREELG ::::::::::::::::::::: NP_003 LEDPHAKKMPKKIGKTREELG 1030 1040 >>NP_001157711 (OMIM: 603405) putative pre-mRNA-splicing (981 aa) initn: 6323 init1: 6323 opt: 6323 Z-score: 3203.9 bits: 604.4 E(85289): 1e-171 Smith-Waterman score: 6323; 100.0% identity (100.0% similar) in 973 aa overlap (69-1041:9-981) 40 50 60 70 80 90 pF1KA0 SAEEFVQRLRDTDTLDLSGPARDFALRLWNKVPRKAVVEKPARAAEREARALLEKNRSYR :::::::::::::::::::::::::::::: NP_001 MSEDPRGPKVPRKAVVEKPARAAEREARALLEKNRSYR 10 20 30 100 110 120 130 140 150 pF1KA0 LLEDSEESSEETVSRAGSSLQKKRKKRKHLRKKREEEEEEEASEKGKKKTGGSKQQTEKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLEDSEESSEETVSRAGSSLQKKRKKRKHLRKKREEEEEEEASEKGKKKTGGSKQQTEKP 40 50 60 70 80 90 160 170 180 190 200 210 pF1KA0 ESEDEWERTERERLQDLEERDAFAERVRQRDKDRTRNVLERSDKKAYEEAQKRLKMAEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESEDEWERTERERLQDLEERDAFAERVRQRDKDRTRNVLERSDKKAYEEAQKRLKMAEED 100 110 120 130 140 150 220 230 240 250 260 270 pF1KA0 RKAMVPELRKKSRREYLAKREREKLEDLEAELADEEFLFGDVELSRHERQELKYKRRVRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKAMVPELRKKSRREYLAKREREKLEDLEAELADEEFLFGDVELSRHERQELKYKRRVRD 160 170 180 190 200 210 280 290 300 310 320 330 pF1KA0 LAREYRAAGEQEKLEATNRYHMPKETRGQPARAVDLVEEESGAPGEEQRRWEEARLGAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAREYRAAGEQEKLEATNRYHMPKETRGQPARAVDLVEEESGAPGEEQRRWEEARLGAAS 220 230 240 250 260 270 340 350 360 370 380 390 pF1KA0 LKFGARDAASQEPKYQLVLEEEETIEFVRATQLQGDEEPSAPPTSTQAQQKESIQAVRRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKFGARDAASQEPKYQLVLEEEETIEFVRATQLQGDEEPSAPPTSTQAQQKESIQAVRRS 280 290 300 310 320 330 400 410 420 430 440 450 pF1KA0 LPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTNKGMKIACTQPRRVAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTNKGMKIACTQPRRVAA 340 350 360 370 380 390 460 470 480 490 500 510 pF1KA0 MSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYSVVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYSVVM 400 410 420 430 440 450 520 530 540 550 560 570 pF1KA0 VDEAHERTLHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDDAPVFRIPGRRFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDEAHERTLHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDDAPVFRIPGRRFP 460 470 480 490 500 510 580 590 600 610 620 630 pF1KA0 VDIFYTKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQEEIEAACEMLQDRCRRLGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDIFYTKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQEEIEAACEMLQDRCRRLGSK 520 530 540 550 560 570 640 650 660 670 680 690 pF1KA0 IRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFCKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFCKQK 580 590 600 610 620 630 700 710 720 730 740 750 pF1KA0 SYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRT 640 650 660 670 680 690 760 770 780 790 800 810 pF1KA0 SLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGALNHLGELTTSGRKMAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGALNHLGELTTSGRKMAEL 700 710 720 730 740 750 820 830 840 850 860 870 pF1KA0 PVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLPGGDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLPGGDH 760 770 780 790 800 810 880 890 900 910 920 930 pF1KA0 LVLLNVYTQWAESGYSSQWCYENFVQFRSMRRARDVREQLEGLLERVEVGLSSCQGDYIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVLLNVYTQWAESGYSSQWCYENFVQFRSMRRARDVREQLEGLLERVEVGLSSCQGDYIR 820 830 840 850 860 870 940 950 960 970 980 990 pF1KA0 VRKAITAGYFYHTARLTRSGYRTVKQQQTVFIHPNSSLFEQQPRWLLYHELVLTTKEFMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRKAITAGYFYHTARLTRSGYRTVKQQQTVFIHPNSSLFEQQPRWLLYHELVLTTKEFMR 880 890 900 910 920 930 1000 1010 1020 1030 1040 pF1KA0 QVLEIESSWLLEVAPHYYKAKELEDPHAKKMPKKIGKTREELG ::::::::::::::::::::::::::::::::::::::::::: NP_001 QVLEIESSWLLEVAPHYYKAKELEDPHAKKMPKKIGKTREELG 940 950 960 970 980 >>XP_011513240 (OMIM: 603405) PREDICTED: putative pre-mR (742 aa) initn: 4866 init1: 4866 opt: 4866 Z-score: 2472.5 bits: 468.6 E(85289): 5.6e-131 Smith-Waterman score: 4866; 100.0% identity (100.0% similar) in 742 aa overlap (300-1041:1-742) 270 280 290 300 310 320 pF1KA0 LKYKRRVRDLAREYRAAGEQEKLEATNRYHMPKETRGQPARAVDLVEEESGAPGEEQRRW :::::::::::::::::::::::::::::: XP_011 MPKETRGQPARAVDLVEEESGAPGEEQRRW 10 20 30 330 340 350 360 370 380 pF1KA0 EEARLGAASLKFGARDAASQEPKYQLVLEEEETIEFVRATQLQGDEEPSAPPTSTQAQQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEARLGAASLKFGARDAASQEPKYQLVLEEEETIEFVRATQLQGDEEPSAPPTSTQAQQK 40 50 60 70 80 90 390 400 410 420 430 440 pF1KA0 ESIQAVRRSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTNKGMKIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESIQAVRRSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTNKGMKIA 100 110 120 130 140 150 450 460 470 480 490 500 pF1KA0 CTQPRRVAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CTQPRRVAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEP 160 170 180 190 200 210 510 520 530 540 550 560 pF1KA0 DLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDDAPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDDAPV 220 230 240 250 260 270 570 580 590 600 610 620 pF1KA0 FRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQEEIEAACEMLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQEEIEAACEMLQ 280 290 300 310 320 330 630 640 650 660 670 680 pF1KA0 DRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYV 340 350 360 370 380 390 690 700 710 720 730 740 pF1KA0 LDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEE 400 410 420 430 440 450 750 760 770 780 790 800 pF1KA0 TTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGALNHLGELT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGALNHLGELT 460 470 480 490 500 510 810 820 830 840 850 860 pF1KA0 TSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHADNARV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHADNARV 520 530 540 550 560 570 870 880 890 900 910 920 pF1KA0 NFFLPGGDHLVLLNVYTQWAESGYSSQWCYENFVQFRSMRRARDVREQLEGLLERVEVGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NFFLPGGDHLVLLNVYTQWAESGYSSQWCYENFVQFRSMRRARDVREQLEGLLERVEVGL 580 590 600 610 620 630 930 940 950 960 970 980 pF1KA0 SSCQGDYIRVRKAITAGYFYHTARLTRSGYRTVKQQQTVFIHPNSSLFEQQPRWLLYHEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSCQGDYIRVRKAITAGYFYHTARLTRSGYRTVKQQQTVFIHPNSSLFEQQPRWLLYHEL 640 650 660 670 680 690 990 1000 1010 1020 1030 1040 pF1KA0 VLTTKEFMRQVLEIESSWLLEVAPHYYKAKELEDPHAKKMPKKIGKTREELG :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLTTKEFMRQVLEIESSWLLEVAPHYYKAKELEDPHAKKMPKKIGKTREELG 700 710 720 730 740 >>XP_011513241 (OMIM: 603405) PREDICTED: putative pre-mR (742 aa) initn: 4866 init1: 4866 opt: 4866 Z-score: 2472.5 bits: 468.6 E(85289): 5.6e-131 Smith-Waterman score: 4866; 100.0% identity (100.0% similar) in 742 aa overlap (300-1041:1-742) 270 280 290 300 310 320 pF1KA0 LKYKRRVRDLAREYRAAGEQEKLEATNRYHMPKETRGQPARAVDLVEEESGAPGEEQRRW :::::::::::::::::::::::::::::: XP_011 MPKETRGQPARAVDLVEEESGAPGEEQRRW 10 20 30 330 340 350 360 370 380 pF1KA0 EEARLGAASLKFGARDAASQEPKYQLVLEEEETIEFVRATQLQGDEEPSAPPTSTQAQQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEARLGAASLKFGARDAASQEPKYQLVLEEEETIEFVRATQLQGDEEPSAPPTSTQAQQK 40 50 60 70 80 90 390 400 410 420 430 440 pF1KA0 ESIQAVRRSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTNKGMKIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESIQAVRRSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTNKGMKIA 100 110 120 130 140 150 450 460 470 480 490 500 pF1KA0 CTQPRRVAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CTQPRRVAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEP 160 170 180 190 200 210 510 520 530 540 550 560 pF1KA0 DLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDDAPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDDAPV 220 230 240 250 260 270 570 580 590 600 610 620 pF1KA0 FRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQEEIEAACEMLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQEEIEAACEMLQ 280 290 300 310 320 330 630 640 650 660 670 680 pF1KA0 DRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYV 340 350 360 370 380 390 690 700 710 720 730 740 pF1KA0 LDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEE 400 410 420 430 440 450 750 760 770 780 790 800 pF1KA0 TTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGALNHLGELT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGALNHLGELT 460 470 480 490 500 510 810 820 830 840 850 860 pF1KA0 TSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHADNARV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHADNARV 520 530 540 550 560 570 870 880 890 900 910 920 pF1KA0 NFFLPGGDHLVLLNVYTQWAESGYSSQWCYENFVQFRSMRRARDVREQLEGLLERVEVGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NFFLPGGDHLVLLNVYTQWAESGYSSQWCYENFVQFRSMRRARDVREQLEGLLERVEVGL 580 590 600 610 620 630 930 940 950 960 970 980 pF1KA0 SSCQGDYIRVRKAITAGYFYHTARLTRSGYRTVKQQQTVFIHPNSSLFEQQPRWLLYHEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSCQGDYIRVRKAITAGYFYHTARLTRSGYRTVKQQQTVFIHPNSSLFEQQPRWLLYHEL 640 650 660 670 680 690 990 1000 1010 1020 1030 1040 pF1KA0 VLTTKEFMRQVLEIESSWLLEVAPHYYKAKELEDPHAKKMPKKIGKTREELG :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLTTKEFMRQVLEIESSWLLEVAPHYYKAKELEDPHAKKMPKKIGKTREELG 700 710 720 730 740 >>XP_011513242 (OMIM: 603405) PREDICTED: putative pre-mR (560 aa) initn: 3474 init1: 3474 opt: 3474 Z-score: 1773.8 bits: 339.0 E(85289): 4.6e-92 Smith-Waterman score: 3474; 100.0% identity (100.0% similar) in 526 aa overlap (516-1041:35-560) 490 500 510 520 530 540 pF1KA0 CTSERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPE :::::::::::::::::::::::::::::: XP_011 PAQECLMQMFLPIEPACFVEWLGTSPSQLGVVMVDEAHERTLHTDILFGLIKDVARFRPE 10 20 30 40 50 60 550 560 570 580 590 600 pF1KA0 LKVLVASATMDTARFSTFFDDAPVFRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKVLVASATMDTARFSTFFDDAPVFRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVT 70 80 90 100 110 120 610 620 630 640 650 660 pF1KA0 QPPGDILVFLTGQEEIEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QPPGDILVFLTGQEEIEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPP 130 140 150 160 170 180 670 680 690 700 710 720 pF1KA0 GARKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GARKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGR 190 200 210 220 230 240 730 740 750 760 770 780 pF1KA0 AGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPP 250 260 270 280 290 300 790 800 810 820 830 840 pF1KA0 YETLLLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YETLLLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAA 310 320 330 340 350 360 850 860 870 880 890 900 pF1KA0 MLSVNNSIFYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAESGYSSQWCYENFVQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLSVNNSIFYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAESGYSSQWCYENFVQF 370 380 390 400 410 420 910 920 930 940 950 960 pF1KA0 RSMRRARDVREQLEGLLERVEVGLSSCQGDYIRVRKAITAGYFYHTARLTRSGYRTVKQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSMRRARDVREQLEGLLERVEVGLSSCQGDYIRVRKAITAGYFYHTARLTRSGYRTVKQQ 430 440 450 460 470 480 970 980 990 1000 1010 1020 pF1KA0 QTVFIHPNSSLFEQQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHYYKAKELEDPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QTVFIHPNSSLFEQQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHYYKAKELEDPH 490 500 510 520 530 540 1030 1040 pF1KA0 AKKMPKKIGKTREELG :::::::::::::::: XP_011 AKKMPKKIGKTREELG 550 560 >>XP_011513243 (OMIM: 603405) PREDICTED: putative pre-mR (524 aa) initn: 3464 init1: 3464 opt: 3464 Z-score: 1769.2 bits: 338.0 E(85289): 8.3e-92 Smith-Waterman score: 3464; 100.0% identity (100.0% similar) in 524 aa overlap (518-1041:1-524) 490 500 510 520 530 540 pF1KA0 SERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPELK :::::::::::::::::::::::::::::: XP_011 MVDEAHERTLHTDILFGLIKDVARFRPELK 10 20 30 550 560 570 580 590 600 pF1KA0 VLVASATMDTARFSTFFDDAPVFRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLVASATMDTARFSTFFDDAPVFRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQP 40 50 60 70 80 90 610 620 630 640 650 660 pF1KA0 PGDILVFLTGQEEIEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGDILVFLTGQEEIEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPPGA 100 110 120 130 140 150 670 680 690 700 710 720 pF1KA0 RKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAG 160 170 180 190 200 210 730 740 750 760 770 780 pF1KA0 RVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYE 220 230 240 250 260 270 790 800 810 820 830 840 pF1KA0 TLLLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLLLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAML 280 290 300 310 320 330 850 860 870 880 890 900 pF1KA0 SVNNSIFYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAESGYSSQWCYENFVQFRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVNNSIFYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAESGYSSQWCYENFVQFRS 340 350 360 370 380 390 910 920 930 940 950 960 pF1KA0 MRRARDVREQLEGLLERVEVGLSSCQGDYIRVRKAITAGYFYHTARLTRSGYRTVKQQQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRRARDVREQLEGLLERVEVGLSSCQGDYIRVRKAITAGYFYHTARLTRSGYRTVKQQQT 400 410 420 430 440 450 970 980 990 1000 1010 1020 pF1KA0 VFIHPNSSLFEQQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHYYKAKELEDPHAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VFIHPNSSLFEQQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHYYKAKELEDPHAK 460 470 480 490 500 510 1030 1040 pF1KA0 KMPKKIGKTREELG :::::::::::::: XP_011 KMPKKIGKTREELG 520 >>NP_001309145 (OMIM: 600396) ATP-dependent RNA helicase (945 aa) initn: 2591 init1: 1960 opt: 2590 Z-score: 1326.3 bits: 256.9 E(85289): 3.9e-67 Smith-Waterman score: 2604; 48.7% identity (75.0% similar) in 855 aa overlap (189-1039:108-924) 160 170 180 190 200 210 pF1KA0 ESEDEWERTERERLQDLEERDAFAERVRQRDKDRTRNVLER-SDKKAYEEAQKRLKMAEE : . :. : : :: . .: :.. :. NP_001 NLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWE--IKQMIAANV 80 90 100 110 120 130 220 230 240 250 260 270 pF1KA0 DRKAMVPELRKKSRREYLAKREREKLEDLEAELADEEFLFGDVELSRHERQELKYK--RR : :.. ... : : . :. :::: ::..:: : : : .: . .. . NP_001 LSKEEFPDFDEET--GILPKVDDEEDEDLEIELVEEEPPF----LRGHTKQSMDMSPIKI 140 150 160 170 180 280 290 300 310 320 330 pF1KA0 VRDLAREYRAAGEQEKLEATNRYHMPKETRGQPARAVDLVEEESGAPGEEQRRWEEARLG :.. :. ... : .: .. . : : .. : ...: . NP_001 VKNPDGSLSQAAMMQSALAKERRELKQAQREA---------EMDSIPMGLNKHWVDPLPD 190 200 210 220 230 240 340 350 360 370 380 390 pF1KA0 AASLKFGARDAASQEPKYQLVLEEEETIEFVRATQLQGDEEPSAPPTSTQAQQKESIQAV : : . ::... .. . : . . :.. .: . . :: NP_001 AE----GRQIAANMRGIGMM----PNDIPEWKKHAFGGNK------ASYGKKTQMSILEQ 250 260 270 280 400 410 420 430 440 450 pF1KA0 RRSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTNKGMKIACTQPRR :.:::.. ..:.:. :. ..:.::. ::::::::::: ::: : :::..: ::.:::::: NP_001 RESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRG-KIGCTQPRR 290 300 310 320 330 340 460 470 480 490 500 510 pF1KA0 VAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYS ::::::: ::..:.: ::.::::.:::::::: .::..:::::::::: : .:::..:. NP_001 VAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYA 350 360 370 380 390 400 520 530 540 550 560 570 pF1KA0 VVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDDAPVFRIPGR ..:.:::::::.:::.::::.: ... : ..:..:.:::.:...:: .: .::.: :::: NP_001 IIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGR 410 420 430 440 450 460 580 590 600 610 620 630 pF1KA0 RFPVDIFYTKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQEEIEAACEMLQDRCRRL .::.:.::: ::.:::.: ...:.:::.:.:::::::::::::::..:::.: .: . : NP_001 TYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSL 470 480 490 500 510 520 640 650 660 670 680 690 pF1KA0 GSKIRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFC : . ::..::.:. :::.::.:::.:.:::.::::.:::::::::::.:: ::.:::: NP_001 GPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFV 530 540 550 560 570 580 700 710 720 730 740 750 pF1KA0 KQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEI ::: :: .::...:.::: :.:.:.::::::::.. :::.:::: ::. :. :.:::: NP_001 KQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEI 590 600 610 620 630 640 760 770 780 790 800 810 pF1KA0 QRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGALNHLGELTTSGRKM :::.:...:: ::..::.::. :::.: ::.:::. :.::::.::::. : :: ::.: NP_001 QRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRM 650 660 670 680 690 700 820 830 840 850 860 870 pF1KA0 AELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLPG ::.:..::: ::.. : . .::::.::...::::.: .::::::: . ::. ...: NP_001 AEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQN-VFYRPKDKQALADQKKAKFHQTE 710 720 730 740 750 760 880 890 900 910 920 930 pF1KA0 GDHLVLLNVYTQWAESGYSSQWCYENFVQFRSMRRARDVREQLEGLLERVEVGLSSCQGD ::::.:: ::..: .. .:. ::::::.: ::.:::.:.:.:. :...: .. . :: . NP_001 GDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKS 770 780 790 800 810 820 940 950 960 970 980 990 pF1KA0 YIRVRKAITAGYFYHTARLT-RSGYRTVKQQQTVFIHPNSSLFEQQPRWLLYHELVLTTK .::.::: .:.: ..:. . ::::. .::.:.:::.:.::..::.:..::::::::: NP_001 TVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTK 830 840 850 860 870 880 1000 1010 1020 1030 1040 pF1KA0 EFMRQVLEIESSWLLEVAPHYYKAKELEDPHAKKMPKKIGKTREELG :.::.: :. ::.: :: ..:.. :: :. :. . : : NP_001 EYMREVTTIDPRWLVEFAPAFFKVS---DP--TKLSKQKKQQRLEPLYNRYEEPNAWRIS 890 900 910 920 930 NP_001 RAFRRR 940 >>NP_001309146 (OMIM: 600396) ATP-dependent RNA helicase (1129 aa) initn: 2652 init1: 1960 opt: 2590 Z-score: 1325.3 bits: 257.0 E(85289): 4.4e-67 Smith-Waterman score: 2604; 48.7% identity (75.0% similar) in 855 aa overlap (189-1039:292-1108) 160 170 180 190 200 210 pF1KA0 ESEDEWERTERERLQDLEERDAFAERVRQRDKDRTRNVLER-SDKKAYEEAQKRLKMAEE : . :. : : :: . .: :.. :. NP_001 NLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWE--IKQMIAANV 270 280 290 300 310 220 230 240 250 260 270 pF1KA0 DRKAMVPELRKKSRREYLAKREREKLEDLEAELADEEFLFGDVELSRHERQELKYK--RR : :.. ... : : . :. :::: ::..:: : : : .: . .. . NP_001 LSKEEFPDFDEET--GILPKVDDEEDEDLEIELVEEEPPF----LRGHTKQSMDMSPIKI 320 330 340 350 360 370 280 290 300 310 320 330 pF1KA0 VRDLAREYRAAGEQEKLEATNRYHMPKETRGQPARAVDLVEEESGAPGEEQRRWEEARLG :.. :. ... : .: .. . : : .. : ...: . NP_001 VKNPDGSLSQAAMMQSALAKERRELKQAQREA---------EMDSIPMGLNKHWVDPLPD 380 390 400 410 420 340 350 360 370 380 390 pF1KA0 AASLKFGARDAASQEPKYQLVLEEEETIEFVRATQLQGDEEPSAPPTSTQAQQKESIQAV : : . ::... .. . : . . :.. .: . . :: NP_001 AE----GRQIAANMRGIGMM----PNDIPEWKKHAFGGNK------ASYGKKTQMSILEQ 430 440 450 460 470 400 410 420 430 440 450 pF1KA0 RRSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTNKGMKIACTQPRR :.:::.. ..:.:. :. ..:.::. ::::::::::: ::: : :::..: ::.:::::: NP_001 RESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRG-KIGCTQPRR 480 490 500 510 520 460 470 480 490 500 510 pF1KA0 VAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYS ::::::: ::..:.: ::.::::.:::::::: .::..:::::::::: : .:::..:. NP_001 VAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYA 530 540 550 560 570 580 520 530 540 550 560 570 pF1KA0 VVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDDAPVFRIPGR ..:.:::::::.:::.::::.: ... : ..:..:.:::.:...:: .: .::.: :::: NP_001 IIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGR 590 600 610 620 630 640 580 590 600 610 620 630 pF1KA0 RFPVDIFYTKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQEEIEAACEMLQDRCRRL .::.:.::: ::.:::.: ...:.:::.:.:::::::::::::::..:::.: .: . : NP_001 TYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSL 650 660 670 680 690 700 640 650 660 670 680 690 pF1KA0 GSKIRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFC : . ::..::.:. :::.::.:::.:.:::.::::.:::::::::::.:: ::.:::: NP_001 GPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFV 710 720 730 740 750 760 700 710 720 730 740 750 pF1KA0 KQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEI ::: :: .::...:.::: :.:.:.::::::::.. :::.:::: ::. :. :.:::: NP_001 KQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEI 770 780 790 800 810 820 760 770 780 790 800 810 pF1KA0 QRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGALNHLGELTTSGRKM :::.:...:: ::..::.::. :::.: ::.:::. :.::::.::::. : :: ::.: NP_001 QRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRM 830 840 850 860 870 880 820 830 840 850 860 870 pF1KA0 AELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLPG ::.:..::: ::.. : . .::::.::...::::.: .::::::: . ::. ...: NP_001 AEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQN-VFYRPKDKQALADQKKAKFHQTE 890 900 910 920 930 940 880 890 900 910 920 930 pF1KA0 GDHLVLLNVYTQWAESGYSSQWCYENFVQFRSMRRARDVREQLEGLLERVEVGLSSCQGD ::::.:: ::..: .. .:. ::::::.: ::.:::.:.:.:. :...: .. . :: . NP_001 GDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKS 950 960 970 980 990 1000 940 950 960 970 980 990 pF1KA0 YIRVRKAITAGYFYHTARLT-RSGYRTVKQQQTVFIHPNSSLFEQQPRWLLYHELVLTTK .::.::: .:.: ..:. . ::::. .::.:.:::.:.::..::.:..::::::::: NP_001 TVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTK 1010 1020 1030 1040 1050 1060 1000 1010 1020 1030 1040 pF1KA0 EFMRQVLEIESSWLLEVAPHYYKAKELEDPHAKKMPKKIGKTREELG :.::.: :. ::.: :: ..:.. :: :. :. . : : NP_001 EYMREVTTIDPRWLVEFAPAFFKVS---DP--TKLSKQKKQQRLEPLYNRYEEPNAWRIS 1070 1080 1090 1100 1110 1120 NP_001 RAFRRR >>NP_001309150 (OMIM: 600396) ATP-dependent RNA helicase (1218 aa) initn: 2652 init1: 1960 opt: 2590 Z-score: 1324.9 bits: 257.0 E(85289): 4.7e-67 Smith-Waterman score: 2604; 48.7% identity (75.0% similar) in 855 aa overlap (189-1039:381-1197) 160 170 180 190 200 210 pF1KA0 ESEDEWERTERERLQDLEERDAFAERVRQRDKDRTRNVLER-SDKKAYEEAQKRLKMAEE : . :. : : :: . .: :.. :. NP_001 NLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWE--IKQMIAANV 360 370 380 390 400 220 230 240 250 260 270 pF1KA0 DRKAMVPELRKKSRREYLAKREREKLEDLEAELADEEFLFGDVELSRHERQELKYK--RR : :.. ... : : . :. :::: ::..:: : : : .: . .. . NP_001 LSKEEFPDFDEET--GILPKVDDEEDEDLEIELVEEEPPF----LRGHTKQSMDMSPIKI 410 420 430 440 450 460 280 290 300 310 320 330 pF1KA0 VRDLAREYRAAGEQEKLEATNRYHMPKETRGQPARAVDLVEEESGAPGEEQRRWEEARLG :.. :. ... : .: .. . : : .. : ...: . NP_001 VKNPDGSLSQAAMMQSALAKERRELKQAQREA---------EMDSIPMGLNKHWVDPLPD 470 480 490 500 510 340 350 360 370 380 390 pF1KA0 AASLKFGARDAASQEPKYQLVLEEEETIEFVRATQLQGDEEPSAPPTSTQAQQKESIQAV : : . ::... .. . : . . :.. .: . . :: NP_001 AE----GRQIAANMRGIGMM----PNDIPEWKKHAFGGNK------ASYGKKTQMSILEQ 520 530 540 550 400 410 420 430 440 450 pF1KA0 RRSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTNKGMKIACTQPRR :.:::.. ..:.:. :. ..:.::. ::::::::::: ::: : :::..: ::.:::::: NP_001 RESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRG-KIGCTQPRR 560 570 580 590 600 610 460 470 480 490 500 510 pF1KA0 VAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYS ::::::: ::..:.: ::.::::.:::::::: .::..:::::::::: : .:::..:. NP_001 VAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYA 620 630 640 650 660 670 520 530 540 550 560 570 pF1KA0 VVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDDAPVFRIPGR ..:.:::::::.:::.::::.: ... : ..:..:.:::.:...:: .: .::.: :::: NP_001 IIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGR 680 690 700 710 720 730 580 590 600 610 620 630 pF1KA0 RFPVDIFYTKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQEEIEAACEMLQDRCRRL .::.:.::: ::.:::.: ...:.:::.:.:::::::::::::::..:::.: .: . : NP_001 TYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSL 740 750 760 770 780 790 640 650 660 670 680 690 pF1KA0 GSKIRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFC : . ::..::.:. :::.::.:::.:.:::.::::.:::::::::::.:: ::.:::: NP_001 GPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFV 800 810 820 830 840 850 700 710 720 730 740 750 pF1KA0 KQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEI ::: :: .::...:.::: :.:.:.::::::::.. :::.:::: ::. :. :.:::: NP_001 KQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEI 860 870 880 890 900 910 760 770 780 790 800 810 pF1KA0 QRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGALNHLGELTTSGRKM :::.:...:: ::..::.::. :::.: ::.:::. :.::::.::::. : :: ::.: NP_001 QRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRM 920 930 940 950 960 970 820 830 840 850 860 870 pF1KA0 AELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLPG ::.:..::: ::.. : . .::::.::...::::.: .::::::: . ::. ...: NP_001 AEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQN-VFYRPKDKQALADQKKAKFHQTE 980 990 1000 1010 1020 1030 880 890 900 910 920 930 pF1KA0 GDHLVLLNVYTQWAESGYSSQWCYENFVQFRSMRRARDVREQLEGLLERVEVGLSSCQGD ::::.:: ::..: .. .:. ::::::.: ::.:::.:.:.:. :...: .. . :: . NP_001 GDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKS 1040 1050 1060 1070 1080 1090 940 950 960 970 980 990 pF1KA0 YIRVRKAITAGYFYHTARLT-RSGYRTVKQQQTVFIHPNSSLFEQQPRWLLYHELVLTTK .::.::: .:.: ..:. . ::::. .::.:.:::.:.::..::.:..::::::::: NP_001 TVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTK 1100 1110 1120 1130 1140 1150 1000 1010 1020 1030 1040 pF1KA0 EFMRQVLEIESSWLLEVAPHYYKAKELEDPHAKKMPKKIGKTREELG :.::.: :. ::.: :: ..:.. :: :. :. . : : NP_001 EYMREVTTIDPRWLVEFAPAFFKVS---DP--TKLSKQKKQQRLEPLYNRYEEPNAWRIS 1160 1170 1180 1190 1200 1210 NP_001 RAFRRR >>NP_004932 (OMIM: 600396) ATP-dependent RNA helicase DH (1220 aa) initn: 2652 init1: 1960 opt: 2590 Z-score: 1324.9 bits: 257.0 E(85289): 4.7e-67 Smith-Waterman score: 2604; 48.7% identity (75.0% similar) in 855 aa overlap (189-1039:383-1199) 160 170 180 190 200 210 pF1KA0 ESEDEWERTERERLQDLEERDAFAERVRQRDKDRTRNVLER-SDKKAYEEAQKRLKMAEE : . :. : : :: . .: :.. :. NP_004 NLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWE--IKQMIAANV 360 370 380 390 400 410 220 230 240 250 260 270 pF1KA0 DRKAMVPELRKKSRREYLAKREREKLEDLEAELADEEFLFGDVELSRHERQELKYK--RR : :.. ... : : . :. :::: ::..:: : : : .: . .. . NP_004 LSKEEFPDFDEET--GILPKVDDEEDEDLEIELVEEEPPF----LRGHTKQSMDMSPIKI 420 430 440 450 460 280 290 300 310 320 330 pF1KA0 VRDLAREYRAAGEQEKLEATNRYHMPKETRGQPARAVDLVEEESGAPGEEQRRWEEARLG :.. :. ... : .: .. . : : .. : ...: . NP_004 VKNPDGSLSQAAMMQSALAKERRELKQAQREA---------EMDSIPMGLNKHWVDPLPD 470 480 490 500 510 340 350 360 370 380 390 pF1KA0 AASLKFGARDAASQEPKYQLVLEEEETIEFVRATQLQGDEEPSAPPTSTQAQQKESIQAV : : . ::... .. . : . . :.. .: . . :: NP_004 AE----GRQIAANMRGIGMM----PNDIPEWKKHAFGGNK------ASYGKKTQMSILEQ 520 530 540 550 560 400 410 420 430 440 450 pF1KA0 RRSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTNKGMKIACTQPRR :.:::.. ..:.:. :. ..:.::. ::::::::::: ::: : :::..: ::.:::::: NP_004 RESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRG-KIGCTQPRR 570 580 590 600 610 620 460 470 480 490 500 510 pF1KA0 VAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYS ::::::: ::..:.: ::.::::.:::::::: .::..:::::::::: : .:::..:. NP_004 VAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYA 630 640 650 660 670 680 520 530 540 550 560 570 pF1KA0 VVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDDAPVFRIPGR ..:.:::::::.:::.::::.: ... : ..:..:.:::.:...:: .: .::.: :::: NP_004 IIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGR 690 700 710 720 730 740 580 590 600 610 620 630 pF1KA0 RFPVDIFYTKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQEEIEAACEMLQDRCRRL .::.:.::: ::.:::.: ...:.:::.:.:::::::::::::::..:::.: .: . : NP_004 TYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSL 750 760 770 780 790 800 640 650 660 670 680 690 pF1KA0 GSKIRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFC : . ::..::.:. :::.::.:::.:.:::.::::.:::::::::::.:: ::.:::: NP_004 GPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFV 810 820 830 840 850 860 700 710 720 730 740 750 pF1KA0 KQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEI ::: :: .::...:.::: :.:.:.::::::::.. :::.:::: ::. :. :.:::: NP_004 KQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEI 870 880 890 900 910 920 760 770 780 790 800 810 pF1KA0 QRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGALNHLGELTTSGRKM :::.:...:: ::..::.::. :::.: ::.:::. :.::::.::::. : :: ::.: NP_004 QRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRM 930 940 950 960 970 980 820 830 840 850 860 870 pF1KA0 AELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLPG ::.:..::: ::.. : . .::::.::...::::.: .::::::: . ::. ...: NP_004 AEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQN-VFYRPKDKQALADQKKAKFHQTE 990 1000 1010 1020 1030 880 890 900 910 920 930 pF1KA0 GDHLVLLNVYTQWAESGYSSQWCYENFVQFRSMRRARDVREQLEGLLERVEVGLSSCQGD ::::.:: ::..: .. .:. ::::::.: ::.:::.:.:.:. :...: .. . :: . NP_004 GDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKS 1040 1050 1060 1070 1080 1090 940 950 960 970 980 990 pF1KA0 YIRVRKAITAGYFYHTARLT-RSGYRTVKQQQTVFIHPNSSLFEQQPRWLLYHELVLTTK .::.::: .:.: ..:. . ::::. .::.:.:::.:.::..::.:..::::::::: NP_004 TVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTK 1100 1110 1120 1130 1140 1150 1000 1010 1020 1030 1040 pF1KA0 EFMRQVLEIESSWLLEVAPHYYKAKELEDPHAKKMPKKIGKTREELG :.::.: :. ::.: :: ..:.. :: :. :. . : : NP_004 EYMREVTTIDPRWLVEFAPAFFKVS---DP--TKLSKQKKQQRLEPLYNRYEEPNAWRIS 1160 1170 1180 1190 1200 1210 NP_004 RAFRRR 1220 1041 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 09:45:19 2016 done: Thu Nov 3 09:45:22 2016 Total Scan time: 16.600 Total Display time: 0.370 Function used was FASTA [36.3.4 Apr, 2011]