FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0597, 910 aa 1>>>pF1KA0597 910 - 910 aa - 910 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2114+/-0.00042; mu= 17.7335+/- 0.026 mean_var=129.9156+/-25.398, 0's: 0 Z-trim(115.9): 66 B-trim: 29 in 1/49 Lambda= 0.112524 statistics sampled from 26537 (26603) to 26537 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.643), E-opt: 0.2 (0.312), width: 16 Scan time: 14.170 The best scores are: opt bits E(85289) NP_005876 (OMIM: 613297) E3 ubiquitin-protein liga ( 910) 6182 1016.0 0 XP_011512234 (OMIM: 613297) PREDICTED: E3 ubiquiti ( 842) 5672 933.2 0 NP_001257589 (OMIM: 613297) E3 ubiquitin-protein l ( 862) 5380 885.8 0 NP_001257590 (OMIM: 613297) E3 ubiquitin-protein l ( 805) 5369 884.0 0 XP_011512236 (OMIM: 613297) PREDICTED: E3 ubiquiti ( 791) 5213 858.6 0 XP_011512238 (OMIM: 613297) PREDICTED: E3 ubiquiti ( 637) 4341 717.0 7.3e-206 XP_011512239 (OMIM: 613297) PREDICTED: E3 ubiquiti ( 510) 3398 563.8 7.6e-160 XP_016864433 (OMIM: 613297) PREDICTED: E3 ubiquiti ( 460) 3075 511.3 4.3e-144 XP_011537797 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 291) 260 54.1 1.1e-06 NP_001002266 (OMIM: 613335) E3 ubiquitin-protein l ( 291) 260 54.1 1.1e-06 XP_016871383 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 291) 260 54.1 1.1e-06 NP_659458 (OMIM: 613335) E3 ubiquitin-protein liga ( 291) 260 54.1 1.1e-06 NP_060393 (OMIM: 613331) E3 ubiquitin-protein liga ( 272) 258 53.8 1.4e-06 XP_016863824 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 285) 258 53.8 1.4e-06 XP_016863825 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 285) 258 53.8 1.4e-06 XP_016863823 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 289) 258 53.8 1.4e-06 NP_001159845 (OMIM: 613331) E3 ubiquitin-protein l ( 289) 258 53.8 1.4e-06 XP_011537795 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 257 53.9 2.6e-06 NP_001269795 (OMIM: 613335) E3 ubiquitin-protein l ( 573) 257 53.9 2.6e-06 XP_011537794 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 257 53.9 2.6e-06 XP_006717767 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 257 53.9 2.6e-06 XP_011537796 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 257 53.9 2.6e-06 XP_005271861 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 257 53.9 2.6e-06 XP_011530357 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 545) 249 52.6 6.1e-06 XP_016864504 (OMIM: 613333) PREDICTED: E3 ubiquiti ( 154) 210 45.7 0.0002 NP_848545 (OMIM: 613333) E3 ubiquitin-protein liga ( 253) 210 46.0 0.00029 XP_011541432 (OMIM: 613333) PREDICTED: E3 ubiquiti ( 280) 210 46.0 0.00031 XP_011541433 (OMIM: 613333) PREDICTED: E3 ubiquiti ( 280) 210 46.0 0.00031 XP_011541431 (OMIM: 613333) PREDICTED: E3 ubiquiti ( 280) 210 46.0 0.00031 XP_005257163 (OMIM: 613337) PREDICTED: probable E3 ( 752) 210 46.4 0.00061 XP_005257160 (OMIM: 613337) PREDICTED: probable E3 ( 799) 210 46.5 0.00064 NP_001275709 (OMIM: 613337) probable E3 ubiquitin- ( 799) 210 46.5 0.00064 XP_011522739 (OMIM: 613337) PREDICTED: probable E3 ( 807) 210 46.5 0.00065 NP_001094345 (OMIM: 613337) probable E3 ubiquitin- ( 808) 210 46.5 0.00065 NP_689811 (OMIM: 613337) probable E3 ubiquitin-pro ( 808) 210 46.5 0.00065 XP_005257159 (OMIM: 613337) PREDICTED: probable E3 ( 824) 210 46.5 0.00066 XP_005257157 (OMIM: 613337) PREDICTED: probable E3 ( 825) 210 46.5 0.00066 XP_011522738 (OMIM: 613337) PREDICTED: probable E3 ( 825) 210 46.5 0.00066 NP_001275708 (OMIM: 613337) probable E3 ubiquitin- ( 846) 210 46.5 0.00067 XP_011522737 (OMIM: 613337) PREDICTED: probable E3 ( 862) 210 46.5 0.00068 XP_005257155 (OMIM: 613337) PREDICTED: probable E3 ( 862) 210 46.5 0.00068 XP_005257153 (OMIM: 613337) PREDICTED: probable E3 ( 863) 210 46.5 0.00068 XP_005257152 (OMIM: 613337) PREDICTED: probable E3 ( 863) 210 46.5 0.00068 XP_005257154 (OMIM: 613337) PREDICTED: probable E3 ( 863) 210 46.5 0.00068 NP_001005416 (OMIM: 613332) E3 ubiquitin-protein l ( 176) 190 42.6 0.0021 XP_006722826 (OMIM: 613332) PREDICTED: E3 ubiquiti ( 176) 190 42.6 0.0021 XP_016882342 (OMIM: 613332) PREDICTED: E3 ubiquiti ( 246) 190 42.7 0.0027 NP_057580 (OMIM: 613332) E3 ubiquitin-protein liga ( 246) 190 42.7 0.0027 NP_001005415 (OMIM: 613332) E3 ubiquitin-protein l ( 246) 190 42.7 0.0027 XP_011526348 (OMIM: 613332) PREDICTED: E3 ubiquiti ( 256) 190 42.7 0.0027 >>NP_005876 (OMIM: 613297) E3 ubiquitin-protein ligase M (910 aa) initn: 6182 init1: 6182 opt: 6182 Z-score: 5430.1 bits: 1016.0 E(85289): 0 Smith-Waterman score: 6182; 100.0% identity (100.0% similar) in 910 aa overlap (1-910:1-910) 10 20 30 40 50 60 pF1KA0 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 ILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 EQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 GEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 WLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 WLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 LIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 PQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 MQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGS 850 860 870 880 890 900 910 pF1KA0 SPPPPQSSQE :::::::::: NP_005 SPPPPQSSQE 910 >>XP_011512234 (OMIM: 613297) PREDICTED: E3 ubiquitin-pr (842 aa) initn: 5672 init1: 5672 opt: 5672 Z-score: 4983.1 bits: 933.2 E(85289): 0 Smith-Waterman score: 5672; 100.0% identity (100.0% similar) in 842 aa overlap (69-910:1-842) 40 50 60 70 80 90 pF1KA0 CLVQWLKHSRKEYCELCKHRFAFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTL :::::::::::::::::::::::::::::: XP_011 MPSRLPIQDIFAGLVTSIGTAIRYWFHYTL 10 20 30 100 110 120 130 140 150 pF1KA0 VAFAWLGVVPLTACRIYKCLFTGSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAFAWLGVVPLTACRIYKCLFTGSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFI 40 50 60 70 80 90 160 170 180 190 200 210 pF1KA0 SLVWLREQIVHGGAPIWLEHAAPPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLVWLREQIVHGGAPIWLEHAAPPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVV 100 110 120 130 140 150 220 230 240 250 260 270 pF1KA0 GENPDAQDDQAEEEEEDNEEEDDAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GENPDAQDDQAEEEEEDNEEEDDAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERML 160 170 180 190 200 210 280 290 300 310 320 330 pF1KA0 GLDGSLVFLEHVFWVVSLNTLFILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLDGSLVFLEHVFWVVSLNTLFILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIV 220 230 240 250 260 270 340 350 360 370 380 390 pF1KA0 GYILLAITLIICHGLATLVKFHRSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GYILLAITLIICHGLATLVKFHRSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICS 280 290 300 310 320 330 400 410 420 430 440 450 pF1KA0 LEMFDATLKDRELSFQSAPGTTMFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEMFDATLKDRELSFQSAPGTTMFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLN 340 350 360 370 380 390 460 470 480 490 500 510 pF1KA0 DPDFNPVQEMIHLPIYRHLRRFILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DPDFNPVQEMIHLPIYRHLRRFILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYS 400 410 420 430 440 450 520 530 540 550 560 570 pF1KA0 DAPVSELSLELLLLQVVLPALLEQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAPVSELSLELLLLQVVLPALLEQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENE 460 470 480 490 500 510 580 590 600 610 620 630 pF1KA0 NSANQQVNNNQHARNNNAIPVVGEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSANQQVNNNQHARNNNAIPVVGEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIV 520 530 540 550 560 570 640 650 660 670 680 690 pF1KA0 FMCITLLIASLICLTLPVFAGRWLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FMCITLLIASLICLTLPVFAGRWLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAW 580 590 600 610 620 630 700 710 720 730 740 750 pF1KA0 MPQGRRVIFQKVKEWSLMIMKTLIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPQGRRVIFQKVKEWSLMIMKTLIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFY 640 650 660 670 680 690 760 770 780 790 800 810 pF1KA0 PWQDWALGVLHAKIIAAITLMGPQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PWQDWALGVLHAKIIAAITLMGPQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLL 700 710 720 730 740 750 820 830 840 850 860 870 pF1KA0 LSLCVPYVIASGVVPLLGVTAEMQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSLCVPYVIASGVVPLLGVTAEMQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIK 760 770 780 790 800 810 880 890 900 910 pF1KA0 NDKYLVGQRLVNYERKSGKQGSSPPPPQSSQE :::::::::::::::::::::::::::::::: XP_011 NDKYLVGQRLVNYERKSGKQGSSPPPPQSSQE 820 830 840 >>NP_001257589 (OMIM: 613297) E3 ubiquitin-protein ligas (862 aa) initn: 5373 init1: 5373 opt: 5380 Z-score: 4726.8 bits: 885.8 E(85289): 0 Smith-Waterman score: 5736; 94.6% identity (94.6% similar) in 910 aa overlap (1-910:1-862) 10 20 30 40 50 60 pF1KA0 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT ::: :::::::: NP_001 FTP------------------------------------------------SRIYKCLFT 70 130 140 150 160 170 180 pF1KA0 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA 80 90 100 110 120 130 190 200 210 220 230 240 pF1KA0 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED 140 150 160 170 180 190 250 260 270 280 290 300 pF1KA0 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF 200 210 220 230 240 250 310 320 330 340 350 360 pF1KA0 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH 260 270 280 290 300 310 370 380 390 400 410 420 pF1KA0 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT 320 330 340 350 360 370 430 440 450 460 470 480 pF1KA0 MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF 380 390 400 410 420 430 490 500 510 520 530 540 pF1KA0 ILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALL 440 450 460 470 480 490 550 560 570 580 590 600 pF1KA0 EQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVV 500 510 520 530 540 550 610 620 630 640 650 660 pF1KA0 GEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGR 560 570 580 590 600 610 670 680 690 700 710 720 pF1KA0 WLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKT 620 630 640 650 660 670 730 740 750 760 770 780 pF1KA0 LIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMG 680 690 700 710 720 730 790 800 810 820 830 840 pF1KA0 PQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAE 740 750 760 770 780 790 850 860 870 880 890 900 pF1KA0 MQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGS 800 810 820 830 840 850 910 pF1KA0 SPPPPQSSQE :::::::::: NP_001 SPPPPQSSQE 860 >>NP_001257590 (OMIM: 613297) E3 ubiquitin-protein ligas (805 aa) initn: 5369 init1: 5369 opt: 5369 Z-score: 4717.5 bits: 884.0 E(85289): 0 Smith-Waterman score: 5369; 100.0% identity (100.0% similar) in 798 aa overlap (113-910:8-805) 90 100 110 120 130 140 pF1KA0 VTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFTGSVSSLLTLPLDMLSTENLLAD :::::::::::::::::::::::::::::: NP_001 MDTAEEGRIYKCLFTGSVSSLLTLPLDMLSTENLLAD 10 20 30 150 160 170 180 190 200 pF1KA0 CLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAAPPFNAAGHHQNEAPAGGNGAEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAAPPFNAAGHHQNEAPAGGNGAEN 40 50 60 70 80 90 210 220 230 240 250 260 pF1KA0 VAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEEDDAGVEDAADANNGAQDDMNWNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEEDDAGVEDAADANNGAQDDMNWNA 100 110 120 130 140 150 270 280 290 300 310 320 pF1KA0 LEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLFILVFAFCPYHIGHFSLVGLGFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLFILVFAFCPYHIGHFSLVGLGFE 160 170 180 190 200 210 330 340 350 360 370 380 pF1KA0 EHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFHRSRRLLGVCYIVVKVSLLVVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFHRSRRLLGVCYIVVKVSLLVVVE 220 230 240 250 260 270 390 400 410 420 430 440 pF1KA0 IGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTTMFLHWLVGMVYVFYFASFILLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTTMFLHWLVGMVYVFYFASFILLL 280 290 300 310 320 330 450 460 470 480 490 500 pF1KA0 REVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRFILSVIVFGSIVLLMLWLPIRII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRFILSVIVFGSIVLLMLWLPIRII 340 350 360 370 380 390 510 520 530 540 550 560 pF1KA0 KSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALLEQGHTRQWLKGLVRAWTVTAGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALLEQGHTRQWLKGLVRAWTVTAGY 400 410 420 430 440 450 570 580 590 600 610 620 pF1KA0 LLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVVGEGLHAAHQAILQQGGPVGFQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVVGEGLHAAHQAILQQGGPVGFQP 460 470 480 490 500 510 630 640 650 660 670 680 pF1KA0 YRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGRWLMSFWTGTAKIHELYTAACGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGRWLMSFWTGTAKIHELYTAACGL 520 530 540 550 560 570 690 700 710 720 730 740 pF1KA0 YVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKTLIVAVLLAGVVPLLLGLLFELV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKTLIVAVLLAGVVPLLLGLLFELV 580 590 600 610 620 630 750 760 770 780 790 800 pF1KA0 IVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMGPQWWLKTVIEQVYANGIRNIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMGPQWWLKTVIEQVYANGIRNIDL 640 650 660 670 680 690 810 820 830 840 850 860 pF1KA0 HYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAEMQNLVHRRIYPFLLMVVVLMAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAEMQNLVHRRIYPFLLMVVVLMAI 700 710 720 730 740 750 870 880 890 900 910 pF1KA0 LSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGSSPPPPQSSQE :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGSSPPPPQSSQE 760 770 780 790 800 >>XP_011512236 (OMIM: 613297) PREDICTED: E3 ubiquitin-pr (791 aa) initn: 5213 init1: 5213 opt: 5213 Z-score: 4580.7 bits: 858.6 E(85289): 0 Smith-Waterman score: 5213; 99.3% identity (99.3% similar) in 769 aa overlap (1-769:1-769) 10 20 30 40 50 60 pF1KA0 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 ILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 EQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 GEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 WLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 LIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMG ::::::::::::::::::::::::::::::::::::::::: : :: XP_011 LIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQMENLHKLHLPENFYLSAFN 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 PQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAE XP_011 GVPTPWIVSPR 790 >>XP_011512238 (OMIM: 613297) PREDICTED: E3 ubiquitin-pr (637 aa) initn: 4341 init1: 4341 opt: 4341 Z-score: 3816.9 bits: 717.0 E(85289): 7.3e-206 Smith-Waterman score: 4341; 100.0% identity (100.0% similar) in 632 aa overlap (1-632:1-632) 10 20 30 40 50 60 pF1KA0 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 ILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 EQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 GEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGR :::::::::::::::::::::::::::::::: XP_011 GEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRTKKAF 610 620 630 670 680 690 700 710 720 pF1KA0 WLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKT >>XP_011512239 (OMIM: 613297) PREDICTED: E3 ubiquitin-pr (510 aa) initn: 3398 init1: 3398 opt: 3398 Z-score: 2990.8 bits: 563.8 E(85289): 7.6e-160 Smith-Waterman score: 3398; 100.0% identity (100.0% similar) in 510 aa overlap (401-910:1-510) 380 390 400 410 420 430 pF1KA0 IVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTTMFLHWLVGMV :::::::::::::::::::::::::::::: XP_011 MFDATLKDRELSFQSAPGTTMFLHWLVGMV 10 20 30 440 450 460 470 480 490 pF1KA0 YVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRFILSVIVFGSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRFILSVIVFGSI 40 50 60 70 80 90 500 510 520 530 540 550 pF1KA0 VLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALLEQGHTRQWLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALLEQGHTRQWLK 100 110 120 130 140 150 560 570 580 590 600 610 pF1KA0 GLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVVGEGLHAAHQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVVGEGLHAAHQA 160 170 180 190 200 210 620 630 640 650 660 670 pF1KA0 ILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGRWLMSFWTGTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGRWLMSFWTGTA 220 230 240 250 260 270 680 690 700 710 720 730 pF1KA0 KIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKTLIVAVLLAGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKTLIVAVLLAGV 280 290 300 310 320 330 740 750 760 770 780 790 pF1KA0 VPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMGPQWWLKTVIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMGPQWWLKTVIE 340 350 360 370 380 390 800 810 820 830 840 850 pF1KA0 QVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAEMQNLVHRRIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAEMQNLVHRRIY 400 410 420 430 440 450 860 870 880 890 900 910 pF1KA0 PFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGSSPPPPQSSQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGSSPPPPQSSQE 460 470 480 490 500 510 >>XP_016864433 (OMIM: 613297) PREDICTED: E3 ubiquitin-pr (460 aa) initn: 3075 init1: 3075 opt: 3075 Z-score: 2707.9 bits: 511.3 E(85289): 4.3e-144 Smith-Waterman score: 3075; 100.0% identity (100.0% similar) in 444 aa overlap (1-444:1-444) 10 20 30 40 50 60 pF1KA0 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF :::::::::::::::::::::::: XP_016 MFLHWLVGMVYVFYFASFILLLREPENEYSIENVGLHGDG 430 440 450 460 >>XP_011537797 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr (291 aa) initn: 255 init1: 255 opt: 260 Z-score: 240.7 bits: 54.1 E(85289): 1.1e-06 Smith-Waterman score: 260; 51.6% identity (72.6% similar) in 62 aa overlap (6-67:77-138) 10 20 30 pF1KA0 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFI .::::.:. :: :.:: :: ::::..:. XP_011 SNISKAGSPPSASAPAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFV 50 60 70 80 90 100 40 50 60 70 80 90 pF1KA0 HQECLVQWLKHSRKEYCELCKHRFAFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFH :: :: ::.: : . :::::..: . .: XP_011 HQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAI 110 120 130 140 150 160 100 110 120 130 140 150 pF1KA0 YTLVAFAWLGVVPLTACRIYKCLFTGSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLC XP_011 TCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLW 170 180 190 200 210 220 >>NP_001002266 (OMIM: 613335) E3 ubiquitin-protein ligas (291 aa) initn: 255 init1: 255 opt: 260 Z-score: 240.7 bits: 54.1 E(85289): 1.1e-06 Smith-Waterman score: 260; 51.6% identity (72.6% similar) in 62 aa overlap (6-67:77-138) 10 20 30 pF1KA0 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFI .::::.:. :: :.:: :: ::::..:. NP_001 SNISKAGSPPSASAPAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFV 50 60 70 80 90 100 40 50 60 70 80 90 pF1KA0 HQECLVQWLKHSRKEYCELCKHRFAFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFH :: :: ::.: : . :::::..: . .: NP_001 HQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAI 110 120 130 140 150 160 100 110 120 130 140 150 pF1KA0 YTLVAFAWLGVVPLTACRIYKCLFTGSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLC NP_001 TCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLW 170 180 190 200 210 220 910 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 09:50:15 2016 done: Thu Nov 3 09:50:17 2016 Total Scan time: 14.170 Total Display time: 0.220 Function used was FASTA [36.3.4 Apr, 2011]