FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0705, 1441 aa 1>>>pF1KA0705 1441 - 1441 aa - 1441 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.1498+/-0.000466; mu= -6.0264+/- 0.029 mean_var=528.6381+/-112.069, 0's: 0 Z-trim(122.4): 107 B-trim: 1104 in 1/60 Lambda= 0.055782 statistics sampled from 40292 (40427) to 40292 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.759), E-opt: 0.2 (0.474), width: 16 Scan time: 20.940 The best scores are: opt bits E(85289) NP_001288057 (OMIM: 606382) membrane-associated gu (1441) 9878 811.2 0 XP_016868335 (OMIM: 606382) PREDICTED: membrane-as (1483) 8363 689.3 5.7e-197 XP_016868332 (OMIM: 606382) PREDICTED: membrane-as (1526) 5666 472.3 1.3e-131 NP_036433 (OMIM: 606382) membrane-associated guany (1455) 5492 458.3 2e-127 XP_011515020 (OMIM: 606382) PREDICTED: membrane-as (1497) 5411 451.7 1.9e-125 XP_016868334 (OMIM: 606382) PREDICTED: membrane-as (1495) 5410 451.7 2e-125 XP_016868333 (OMIM: 606382) PREDICTED: membrane-as (1498) 4722 396.3 9.3e-109 XP_016868337 (OMIM: 606382) PREDICTED: membrane-as (1334) 4323 364.1 4e-99 XP_016868338 (OMIM: 606382) PREDICTED: membrane-as (1332) 4322 364.1 4.2e-99 XP_016868331 (OMIM: 606382) PREDICTED: membrane-as (1538) 3213 274.9 3.4e-72 XP_011515030 (OMIM: 606382) PREDICTED: membrane-as (1106) 3207 274.2 3.8e-72 XP_011515028 (OMIM: 606382) PREDICTED: membrane-as (1149) 3207 274.3 3.9e-72 XP_011515021 (OMIM: 606382) PREDICTED: membrane-as (1377) 3207 274.3 4.4e-72 XP_011515022 (OMIM: 606382) PREDICTED: membrane-as (1377) 3207 274.3 4.4e-72 XP_016868336 (OMIM: 606382) PREDICTED: membrane-as (1377) 3207 274.3 4.4e-72 XP_016868330 (OMIM: 606382) PREDICTED: membrane-as (1539) 3207 274.4 4.8e-72 XP_016868329 (OMIM: 606382) PREDICTED: membrane-as (1540) 3207 274.4 4.8e-72 XP_016868340 (OMIM: 606382) PREDICTED: membrane-as (1298) 3187 272.7 1.3e-71 XP_016868339 (OMIM: 606382) PREDICTED: membrane-as (1326) 3186 272.6 1.4e-71 XP_016868341 (OMIM: 606382) PREDICTED: membrane-as (1284) 3181 272.2 1.8e-71 XP_011532538 (OMIM: 602625) PREDICTED: membrane-as (1480) 1741 156.4 1.5e-36 XP_006713473 (OMIM: 602625) PREDICTED: membrane-as (1479) 1722 154.9 4.4e-36 XP_005265625 (OMIM: 602625) PREDICTED: membrane-as (1478) 1716 154.4 6.1e-36 XP_016862997 (OMIM: 602625) PREDICTED: membrane-as (1168) 1690 152.2 2.2e-35 XP_016862996 (OMIM: 602625) PREDICTED: membrane-as (1224) 1690 152.2 2.3e-35 XP_005265623 (OMIM: 602625) PREDICTED: membrane-as (1479) 1687 152.0 3.1e-35 XP_016862995 (OMIM: 602625) PREDICTED: membrane-as (1276) 1594 144.5 5e-33 XP_005265622 (OMIM: 602625) PREDICTED: membrane-as (1481) 1475 135.0 4.2e-30 NP_004733 (OMIM: 602625) membrane-associated guany (1256) 1325 122.8 1.6e-26 NP_056335 (OMIM: 602625) membrane-associated guany (1287) 1325 122.8 1.7e-26 XP_005265631 (OMIM: 602625) PREDICTED: membrane-as (1288) 1325 122.8 1.7e-26 XP_005265628 (OMIM: 602625) PREDICTED: membrane-as (1395) 1325 122.9 1.7e-26 NP_001028229 (OMIM: 602625) membrane-associated gu (1462) 1325 122.9 1.8e-26 XP_006713475 (OMIM: 602625) PREDICTED: membrane-as (1463) 1325 122.9 1.8e-26 XP_016862987 (OMIM: 602625) PREDICTED: membrane-as (1490) 1325 122.9 1.8e-26 XP_005265621 (OMIM: 602625) PREDICTED: membrane-as (1491) 1325 122.9 1.8e-26 XP_016862994 (OMIM: 602625) PREDICTED: membrane-as (1288) 1320 122.4 2.2e-26 XP_016862991 (OMIM: 602625) PREDICTED: membrane-as (1289) 1320 122.4 2.2e-26 XP_016862993 (OMIM: 602625) PREDICTED: membrane-as (1288) 1319 122.4 2.3e-26 XP_016862990 (OMIM: 602625) PREDICTED: membrane-as (1452) 1320 122.5 2.4e-26 XP_016862986 (OMIM: 602625) PREDICTED: membrane-as (1491) 1320 122.5 2.4e-26 XP_006713472 (OMIM: 602625) PREDICTED: membrane-as (1492) 1320 122.5 2.4e-26 XP_006713471 (OMIM: 602625) PREDICTED: membrane-as (1492) 1319 122.4 2.6e-26 XP_016862989 (OMIM: 602625) PREDICTED: membrane-as (1455) 1231 115.3 3.4e-24 XP_016862988 (OMIM: 602625) PREDICTED: membrane-as (1458) 1231 115.3 3.4e-24 XP_016862992 (OMIM: 602625) PREDICTED: membrane-as (1289) 1125 106.8 1.2e-21 XP_006713477 (OMIM: 602625) PREDICTED: membrane-as (1290) 1125 106.8 1.2e-21 XP_005265627 (OMIM: 602625) PREDICTED: membrane-as (1425) 1125 106.8 1.2e-21 XP_006713474 (OMIM: 602625) PREDICTED: membrane-as (1465) 1125 106.8 1.3e-21 XP_005265620 (OMIM: 602625) PREDICTED: membrane-as (1492) 1125 106.8 1.3e-21 >>NP_001288057 (OMIM: 606382) membrane-associated guanyl (1441 aa) initn: 9878 init1: 9878 opt: 9878 Z-score: 4316.3 bits: 811.2 E(85289): 0 Smith-Waterman score: 9878; 100.0% identity (100.0% similar) in 1441 aa overlap (1-1441:1-1441) 10 20 30 40 50 60 pF1KA0 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRRPDYKELDVHLRRMESGFGFRILG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRRPDYKELDVHLRRMESGFGFRILG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 GDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQV 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 NLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASH 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 SLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDR 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 ILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLA 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 QQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 PLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGA 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 KGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELI 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA0 KSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPS 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA0 DPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGG 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA0 QGRPEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGRPEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGG 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KA0 GGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAAS 1390 1400 1410 1420 1430 1440 pF1KA0 R : NP_001 R >>XP_016868335 (OMIM: 606382) PREDICTED: membrane-associ (1483 aa) initn: 9864 init1: 8337 opt: 8363 Z-score: 3657.2 bits: 689.3 E(85289): 5.7e-197 Smith-Waterman score: 9723; 97.1% identity (97.1% similar) in 1473 aa overlap (1-1431:1-1473) 10 20 30 40 50 60 pF1KA0 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRRPDYKELDVHLRRMESGFGFRILG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRRPDYKELDVHLRRMESGFGFRILG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 GDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQV 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 NLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASH 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 SLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDR 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 ILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLA 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 QQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 PLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGA 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 KGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELI 1150 1160 1170 1180 1190 1200 1210 1220 pF1KA0 KSGGRRVRLLLKRGTGQVPEY--------------------------------------- ::::::::::::::::::::: XP_016 KSGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTERSKLARTD 1210 1220 1230 1240 1250 1260 1230 1240 1250 1260 1270 pF1KA0 ---DEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREH ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NRKDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREH 1270 1280 1290 1300 1310 1320 1280 1290 1300 1310 1320 1330 pF1KA0 DVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPGL 1330 1340 1350 1360 1370 1380 1340 1350 1360 1370 1380 1390 pF1KA0 AAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGP 1390 1400 1410 1420 1430 1440 1400 1410 1420 1430 1440 pF1KA0 RPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR ::::::::::::::::::::::::::::::::: XP_016 RPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR 1450 1460 1470 1480 >>XP_016868332 (OMIM: 606382) PREDICTED: membrane-associ (1526 aa) initn: 9850 init1: 5563 opt: 5666 Z-score: 2484.0 bits: 472.3 E(85289): 1.3e-131 Smith-Waterman score: 9551; 94.4% identity (94.4% similar) in 1505 aa overlap (12-1431:12-1516) 10 20 30 40 50 60 pF1KA0 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP 310 320 330 340 350 360 370 380 390 400 pF1KA0 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFR------------ :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFRVDSSSWTLPRPK 370 380 390 400 410 420 410 420 430 pF1KA0 -------------------------------EKPLFTRDASQLKGTFLSTTLKKSNMGFG ::::::::::::::::::::::::::::: XP_016 SIRPRAAPERSRSVNDLSYYQRDPAGRPWLFEKPLFTRDASQLKGTFLSTTLKKSNMGFG 430 440 450 460 470 480 440 450 460 470 480 490 pF1KA0 FTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVP 490 500 510 520 530 540 500 510 520 530 540 550 pF1KA0 IGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQS 550 560 570 580 590 600 560 570 580 590 600 610 pF1KA0 VPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGF 610 620 630 640 650 660 620 630 640 650 660 670 pF1KA0 TIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSL 670 680 690 700 710 720 680 690 700 710 720 730 pF1KA0 IIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDP 730 740 750 760 770 780 740 750 760 770 780 790 pF1KA0 RKPDPYELYEKSRAIYESRRPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKPDPYELYEKSRAIYESRRPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMG 790 800 810 820 830 840 800 810 820 830 840 850 pF1KA0 SADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPE 850 860 870 880 890 900 860 870 880 890 900 910 pF1KA0 NGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGF 910 920 930 940 950 960 920 930 940 950 960 970 pF1KA0 GFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADI 970 980 990 1000 1010 1020 980 990 1000 1010 1020 1030 pF1KA0 VKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPI 1030 1040 1050 1060 1070 1080 1040 1050 1060 1070 1080 1090 pF1KA0 AQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPP 1090 1100 1110 1120 1130 1140 1100 1110 1120 1130 1140 1150 pF1KA0 LDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDL 1150 1160 1170 1180 1190 1200 1160 1170 1180 1190 1200 1210 pF1KA0 YVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQ 1210 1220 1230 1240 1250 1260 1220 1230 pF1KA0 VPEY------------------------------------------DEPAPWSSPAAAAP :::: :::::::::::::: XP_016 VPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTERSKLARTDNRKDEPAPWSSPAAAAP 1270 1280 1290 1300 1310 1320 1240 1250 1260 1270 1280 1290 pF1KA0 GLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQR 1330 1340 1350 1360 1370 1380 1300 1310 1320 1330 1340 1350 pF1KA0 LGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADAADAARAGGKEAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADAADAARAGGKEAP 1390 1400 1410 1420 1430 1440 1360 1370 1380 1390 1400 1410 pF1KA0 RAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAV 1450 1460 1470 1480 1490 1500 1420 1430 1440 pF1KA0 APGPWKVPGSDKLPSVLKPGASAASR :::::::::::::::: XP_016 APGPWKVPGSDKLPSVLKPGASAASR 1510 1520 >>NP_036433 (OMIM: 606382) membrane-associated guanylate (1455 aa) initn: 5312 init1: 5161 opt: 5492 Z-score: 2408.6 bits: 458.3 E(85289): 2e-127 Smith-Waterman score: 9834; 99.0% identity (99.0% similar) in 1455 aa overlap (1-1441:1-1455) 10 20 30 40 50 60 pF1KA0 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP 670 680 690 700 710 720 730 740 750 760 pF1KA0 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRR--------------PDYKELDVH ::::::::::::::::::::::::::::::::::::. ::::::::: NP_036 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVH 730 740 750 760 770 780 770 780 790 800 810 820 pF1KA0 LRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 LRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY 790 800 810 820 830 840 830 840 850 860 870 880 pF1KA0 VIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 VIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAA 850 860 870 880 890 900 890 900 910 920 930 940 pF1KA0 PSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 PSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDG 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KA0 SPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 SPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPS 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KA0 SEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 SEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVK 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 1120 pF1KA0 PDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 PDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQP 1090 1100 1110 1120 1130 1140 1130 1140 1150 1160 1170 1180 pF1KA0 QDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 QDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGE 1150 1160 1170 1180 1190 1200 1190 1200 1210 1220 1230 1240 pF1KA0 STRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 STRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDD 1210 1220 1230 1240 1250 1260 1250 1260 1270 1280 1290 1300 pF1KA0 GLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 GLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASP 1270 1280 1290 1300 1310 1320 1310 1320 1330 1340 1350 1360 pF1KA0 QRAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 QRAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRR 1330 1340 1350 1360 1370 1380 1370 1380 1390 1400 1410 1420 pF1KA0 EGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 EGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSD 1390 1400 1410 1420 1430 1440 1430 1440 pF1KA0 KLPSVLKPGASAASR ::::::::::::::: NP_036 KLPSVLKPGASAASR 1450 >>XP_011515020 (OMIM: 606382) PREDICTED: membrane-associ (1497 aa) initn: 6839 init1: 5161 opt: 5411 Z-score: 2373.2 bits: 451.7 E(85289): 1.9e-125 Smith-Waterman score: 9573; 96.1% identity (96.2% similar) in 1473 aa overlap (1-1417:1-1473) 10 20 30 40 50 60 pF1KA0 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP 670 680 690 700 710 720 730 740 750 760 pF1KA0 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRR--------------PDYKELDVH ::::::::::::::::::::::::::::::::::::. ::::::::: XP_011 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVH 730 740 750 760 770 780 770 780 790 800 810 820 pF1KA0 LRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY 790 800 810 820 830 840 830 840 850 860 870 880 pF1KA0 VIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAA 850 860 870 880 890 900 890 900 910 920 930 940 pF1KA0 PSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDG 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KA0 SPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPS 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KA0 SEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVK 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 1120 pF1KA0 PDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQP 1090 1100 1110 1120 1130 1140 1130 1140 1150 1160 1170 1180 pF1KA0 QDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGE 1150 1160 1170 1180 1190 1200 1190 1200 1210 1220 pF1KA0 STRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEY------------------------- ::::::::::::::::::::::::::::::::::: XP_011 STRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLG 1210 1220 1230 1240 1250 1260 1230 1240 1250 1260 pF1KA0 -----------------DEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSH ::::::::::::::::::::::::::::::::::::::::::: XP_011 HPKDTERSKLARTDNRKDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSH 1270 1280 1290 1300 1310 1320 1270 1280 1290 1300 1310 1320 pF1KA0 QISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRP 1330 1340 1350 1360 1370 1380 1330 1340 1350 1360 1370 1380 pF1KA0 EAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSG 1390 1400 1410 1420 1430 1440 1390 1400 1410 1420 1430 1440 pF1KA0 ALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR ::::::::::::::::::::::::::::::::: XP_011 ALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR 1450 1460 1470 1480 1490 >>XP_016868334 (OMIM: 606382) PREDICTED: membrane-associ (1495 aa) initn: 6834 init1: 5156 opt: 5410 Z-score: 2372.8 bits: 451.7 E(85289): 2e-125 Smith-Waterman score: 9583; 96.2% identity (96.2% similar) in 1473 aa overlap (1-1419:1-1473) 10 20 30 40 50 60 pF1KA0 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP 670 680 690 700 710 720 730 740 750 760 pF1KA0 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYE------------SRRPDYKELDVHLR :::::::::::::::::::::::::::::::::: : ::::::::::: XP_016 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYEKQVPPRTSFRMDSSGPDYKELDVHLR 730 740 750 760 770 780 770 780 790 800 810 820 pF1KA0 RMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVI 790 800 810 820 830 840 830 840 850 860 870 880 pF1KA0 DLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPS 850 860 870 880 890 900 890 900 910 920 930 940 pF1KA0 SNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSP 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KA0 ADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSE 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KA0 KQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPD 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 1120 pF1KA0 IRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQD 1090 1100 1110 1120 1130 1140 1130 1140 1150 1160 1170 1180 pF1KA0 FDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGEST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGEST 1150 1160 1170 1180 1190 1200 1190 1200 1210 1220 pF1KA0 RDMTHARAIELIKSGGRRVRLLLKRGTGQVPEY--------------------------- ::::::::::::::::::::::::::::::::: XP_016 RDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHP 1210 1220 1230 1240 1250 1260 1230 1240 1250 1260 pF1KA0 ---------------DEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQI ::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDTERSKLARTDNRKDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQI 1270 1280 1290 1300 1310 1320 1270 1280 1290 1300 1310 1320 pF1KA0 SPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEA 1330 1340 1350 1360 1370 1380 1330 1340 1350 1360 1370 1380 pF1KA0 GRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGAL 1390 1400 1410 1420 1430 1440 1390 1400 1410 1420 1430 1440 pF1KA0 EAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR ::::::::::::::::::::::::::::::::: XP_016 EAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR 1450 1460 1470 1480 1490 >>XP_016868333 (OMIM: 606382) PREDICTED: membrane-associ (1498 aa) initn: 7474 init1: 4714 opt: 4722 Z-score: 2073.5 bits: 396.3 E(85289): 9.3e-109 Smith-Waterman score: 9572; 96.1% identity (96.1% similar) in 1473 aa overlap (26-1441:26-1498) 10 20 30 40 50 60 pF1KA0 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL ::::::::::::::::::::::::::::::::::: XP_016 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP 310 320 330 340 350 360 370 380 390 400 pF1KA0 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFR------------ :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFRVDSSSWTLPRPK 370 380 390 400 410 420 410 420 430 pF1KA0 -------------------------------EKPLFTRDASQLKGTFLSTTLKKSNMGFG ::::::::::::::::::::::::::::: XP_016 SIRPRAAPERSRSVNDLSYYQRDPAGRPWLFEKPLFTRDASQLKGTFLSTTLKKSNMGFG 430 440 450 460 470 480 440 450 460 470 480 490 pF1KA0 FTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVP 490 500 510 520 530 540 500 510 520 530 540 550 pF1KA0 IGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQS 550 560 570 580 590 600 560 570 580 590 600 610 pF1KA0 VPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGF 610 620 630 640 650 660 620 630 640 650 660 670 pF1KA0 TIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSL 670 680 690 700 710 720 680 690 700 710 720 730 pF1KA0 IIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDP 730 740 750 760 770 780 740 750 760 770 780 pF1KA0 RKPDPYELYEKSRAIYESRR--------------PDYKELDVHLRRMESGFGFRILGGDE :::::::::::::::::::. :::::::::::::::::::::::::: XP_016 RKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDE 790 800 810 820 830 840 790 800 810 820 830 840 pF1KA0 PGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLT 850 860 870 880 890 900 850 860 870 880 890 900 pF1KA0 VRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQ 910 920 930 940 950 960 910 920 930 940 950 960 pF1KA0 TSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILA 970 980 990 1000 1010 1020 970 980 990 1000 1010 1020 pF1KA0 VNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQS 1030 1040 1050 1060 1070 1080 1030 1040 1050 1060 1070 1080 pF1KA0 PLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLD 1090 1100 1110 1120 1130 1140 1090 1100 1110 1120 1130 1140 pF1KA0 YRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGF 1150 1160 1170 1180 1190 1200 1150 1160 1170 1180 1190 1200 pF1KA0 GFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSG 1210 1220 1230 1240 1250 1260 1210 1220 1230 1240 1250 1260 pF1KA0 GRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPS 1270 1280 1290 1300 1310 1320 1270 1280 1290 1300 1310 1320 pF1KA0 HQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGR 1330 1340 1350 1360 1370 1380 1330 1340 1350 1360 1370 1380 pF1KA0 PEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGS 1390 1400 1410 1420 1430 1440 1390 1400 1410 1420 1430 1440 pF1KA0 GALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR 1450 1460 1470 1480 1490 >>XP_016868337 (OMIM: 606382) PREDICTED: membrane-associ (1334 aa) initn: 5751 init1: 4073 opt: 4323 Z-score: 1900.6 bits: 364.1 E(85289): 4e-99 Smith-Waterman score: 8485; 95.6% identity (95.7% similar) in 1310 aa overlap (164-1417:1-1310) 140 150 160 170 180 190 pF1KA0 YLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYEDNYYGTPKPPAEPA :::::::::::::::::::::::::::::: XP_016 MELEKSGALLESGTYEDNYYGTPKPPAEPA 10 20 30 200 210 220 230 240 250 pF1KA0 PLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERPVVNGNGVVVTPES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERPVVNGNGVVVTPES 40 50 60 70 80 90 260 270 280 290 300 310 pF1KA0 SEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEEPDPLPDNWEMAYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEEPDPLPDNWEMAYT 100 110 120 130 140 150 320 330 340 350 360 370 pF1KA0 EKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRR 160 170 180 190 200 210 380 390 400 410 420 430 pF1KA0 TQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSN 220 230 240 250 260 270 440 450 460 470 480 490 pF1KA0 MGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLF 280 290 300 310 320 330 500 510 520 530 540 550 pF1KA0 QSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISR 340 350 360 370 380 390 560 570 580 590 600 610 pF1KA0 TSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQ 400 410 420 430 440 450 620 630 640 650 660 670 pF1KA0 GFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGS 460 470 480 490 500 510 680 690 700 710 720 730 pF1KA0 ETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTE 520 530 540 550 560 570 740 750 760 770 pF1KA0 AFDPRKPDPYELYEKSRAIYESRR--------------PDYKELDVHLRRMESGFGFRIL :::::::::::::::::::::::. :::::::::::::::::::::: XP_016 AFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRIL 580 590 600 610 620 630 780 790 800 810 820 830 pF1KA0 GGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQ 640 650 660 670 680 690 840 850 860 870 880 890 pF1KA0 VNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFAS 700 710 720 730 740 750 900 910 920 930 940 950 pF1KA0 HSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGD 760 770 780 790 800 810 960 970 980 990 1000 1010 pF1KA0 RILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPL 820 830 840 850 860 870 1020 1030 1040 1050 1060 1070 pF1KA0 AQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQ 880 890 900 910 920 930 1080 1090 1100 1110 1120 1130 pF1KA0 PPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKG 940 950 960 970 980 990 1140 1150 1160 1170 1180 1190 pF1KA0 AKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIEL 1000 1010 1020 1030 1040 1050 1200 1210 1220 pF1KA0 IKSGGRRVRLLLKRGTGQVPEY-------------------------------------- :::::::::::::::::::::: XP_016 IKSGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTERSKLART 1060 1070 1080 1090 1100 1110 1230 1240 1250 1260 1270 pF1KA0 ----DEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DNRKDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKRE 1120 1130 1140 1150 1160 1170 1280 1290 1300 1310 1320 1330 pF1KA0 HDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPG 1180 1190 1200 1210 1220 1230 1340 1350 1360 1370 1380 1390 pF1KA0 LAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAG 1240 1250 1260 1270 1280 1290 1400 1410 1420 1430 1440 pF1KA0 PRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR :::::::::::::::::::: XP_016 PRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR 1300 1310 1320 1330 >>XP_016868338 (OMIM: 606382) PREDICTED: membrane-associ (1332 aa) initn: 5746 init1: 4068 opt: 4322 Z-score: 1900.2 bits: 364.1 E(85289): 4.2e-99 Smith-Waterman score: 8495; 95.7% identity (95.7% similar) in 1310 aa overlap (164-1419:1-1310) 140 150 160 170 180 190 pF1KA0 YLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYEDNYYGTPKPPAEPA :::::::::::::::::::::::::::::: XP_016 MELEKSGALLESGTYEDNYYGTPKPPAEPA 10 20 30 200 210 220 230 240 250 pF1KA0 PLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERPVVNGNGVVVTPES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERPVVNGNGVVVTPES 40 50 60 70 80 90 260 270 280 290 300 310 pF1KA0 SEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEEPDPLPDNWEMAYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEEPDPLPDNWEMAYT 100 110 120 130 140 150 320 330 340 350 360 370 pF1KA0 EKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRR 160 170 180 190 200 210 380 390 400 410 420 430 pF1KA0 TQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSN 220 230 240 250 260 270 440 450 460 470 480 490 pF1KA0 MGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLF 280 290 300 310 320 330 500 510 520 530 540 550 pF1KA0 QSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISR 340 350 360 370 380 390 560 570 580 590 600 610 pF1KA0 TSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQ 400 410 420 430 440 450 620 630 640 650 660 670 pF1KA0 GFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGS 460 470 480 490 500 510 680 690 700 710 720 730 pF1KA0 ETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTE 520 530 540 550 560 570 740 750 760 770 780 pF1KA0 AFDPRKPDPYELYEKSRAIYE------------SRRPDYKELDVHLRRMESGFGFRILGG ::::::::::::::::::::: : :::::::::::::::::::::::: XP_016 AFDPRKPDPYELYEKSRAIYEKQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGG 580 590 600 610 620 630 790 800 810 820 830 840 pF1KA0 DEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVN 640 650 660 670 680 690 850 860 870 880 890 900 pF1KA0 LTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHS 700 710 720 730 740 750 910 920 930 940 950 960 pF1KA0 LQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRI 760 770 780 790 800 810 970 980 990 1000 1010 1020 pF1KA0 LAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQ 820 830 840 850 860 870 1030 1040 1050 1060 1070 1080 pF1KA0 QSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPP 880 890 900 910 920 930 1090 1100 1110 1120 1130 1140 pF1KA0 LDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAK 940 950 960 970 980 990 1150 1160 1170 1180 1190 1200 pF1KA0 GFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIK 1000 1010 1020 1030 1040 1050 1210 1220 pF1KA0 SGGRRVRLLLKRGTGQVPEY---------------------------------------- :::::::::::::::::::: XP_016 SGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTERSKLARTDN 1060 1070 1080 1090 1100 1110 1230 1240 1250 1260 1270 pF1KA0 --DEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREHD 1120 1130 1140 1150 1160 1170 1280 1290 1300 1310 1320 1330 pF1KA0 VRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPGLA 1180 1190 1200 1210 1220 1230 1340 1350 1360 1370 1380 1390 pF1KA0 AADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGPR 1240 1250 1260 1270 1280 1290 1400 1410 1420 1430 1440 pF1KA0 PGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR :::::::::::::::::::: XP_016 PGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR 1300 1310 1320 1330 >>XP_016868331 (OMIM: 606382) PREDICTED: membrane-associ (1538 aa) initn: 7460 init1: 3173 opt: 3213 Z-score: 1417.1 bits: 274.9 E(85289): 3.4e-72 Smith-Waterman score: 9425; 93.4% identity (93.4% similar) in 1505 aa overlap (24-1431:24-1528) 10 20 30 40 50 60 pF1KA0 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL ::::::::::::::::::::::::::::::::::::: XP_016 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP 310 320 330 340 350 360 370 380 390 400 pF1KA0 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFR------------ :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFRVDSSSWTLPRPK 370 380 390 400 410 420 410 420 430 pF1KA0 -------------------------------EKPLFTRDASQLKGTFLSTTLKKSNMGFG ::::::::::::::::::::::::::::: XP_016 SIRPRAAPERSRSVNDLSYYQRDPAGRPWLFEKPLFTRDASQLKGTFLSTTLKKSNMGFG 430 440 450 460 470 480 440 450 460 470 480 490 pF1KA0 FTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVP 490 500 510 520 530 540 500 510 520 530 540 550 pF1KA0 IGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQS 550 560 570 580 590 600 560 570 580 590 600 610 pF1KA0 VPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGF 610 620 630 640 650 660 620 630 640 650 660 670 pF1KA0 TIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSL 670 680 690 700 710 720 680 690 700 710 720 730 pF1KA0 IIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDP 730 740 750 760 770 780 740 750 760 770 780 pF1KA0 RKPDPYELYEKSRAIYE------------SRRPDYKELDVHLRRMESGFGFRILGGDEPG ::::::::::::::::: : :::::::::::::::::::::::::::: XP_016 RKPDPYELYEKSRAIYEKQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPG 790 800 810 820 830 840 790 800 810 820 830 840 pF1KA0 QPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVR 850 860 870 880 890 900 850 860 870 880 890 900 pF1KA0 RKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTS 910 920 930 940 950 960 910 920 930 940 950 960 pF1KA0 DVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVN 970 980 990 1000 1010 1020 970 980 990 1000 1010 1020 pF1KA0 GQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPL 1030 1040 1050 1060 1070 1080 1030 1040 1050 1060 1070 1080 pF1KA0 AQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYR 1090 1100 1110 1120 1130 1140 1090 1100 1110 1120 1130 1140 pF1KA0 QPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGF 1150 1160 1170 1180 1190 1200 1150 1160 1170 1180 1190 1200 pF1KA0 SIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGR 1210 1220 1230 1240 1250 1260 1210 1220 pF1KA0 RVRLLLKRGTGQVPEY------------------------------------------DE :::::::::::::::: :: XP_016 RVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTERSKLARTDNRKDE 1270 1280 1290 1300 1310 1320 1230 1240 1250 1260 1270 1280 pF1KA0 PAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKP 1330 1340 1350 1360 1370 1380 1290 1300 1310 1320 1330 1340 pF1KA0 KELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADA 1390 1400 1410 1420 1430 1440 1350 1360 1370 1380 1390 1400 pF1KA0 ADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPR 1450 1460 1470 1480 1490 1500 1410 1420 1430 1440 pF1KA0 PPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR :::::::::::::::::::::::::::: XP_016 PPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR 1510 1520 1530 1441 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 23:21:22 2016 done: Sat Nov 5 23:21:25 2016 Total Scan time: 20.940 Total Display time: 0.750 Function used was FASTA [36.3.4 Apr, 2011]