FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0767, 578 aa 1>>>pF1KA0767 578 - 578 aa - 578 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.4624+/-0.000444; mu= 9.5691+/- 0.027 mean_var=167.6084+/-33.289, 0's: 0 Z-trim(116.6): 37 B-trim: 746 in 1/55 Lambda= 0.099066 statistics sampled from 27806 (27843) to 27806 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.684), E-opt: 0.2 (0.326), width: 16 Scan time: 9.530 The best scores are: opt bits E(85289) XP_016884159 (OMIM: 613691) PREDICTED: GRAM domain ( 578) 3826 559.5 1.1e-158 XP_006724233 (OMIM: 613691) PREDICTED: GRAM domain ( 578) 3826 559.5 1.1e-158 NP_055939 (OMIM: 613691) GRAM domain-containing pr ( 578) 3826 559.5 1.1e-158 XP_006724232 (OMIM: 613691) PREDICTED: GRAM domain ( 601) 3826 559.5 1.1e-158 XP_005261453 (OMIM: 613691) PREDICTED: GRAM domain ( 604) 3826 559.5 1.1e-158 XP_011528313 (OMIM: 613691) PREDICTED: GRAM domain ( 577) 3623 530.5 5.9e-150 XP_011528314 (OMIM: 613691) PREDICTED: GRAM domain ( 555) 3473 509.0 1.6e-143 XP_011528315 (OMIM: 613691) PREDICTED: GRAM domain ( 561) 3470 508.6 2.2e-143 XP_011528316 (OMIM: 613691) PREDICTED: GRAM domain ( 453) 2761 407.2 6e-113 XP_005255017 (OMIM: 616297) PREDICTED: multiple C2 ( 466) 233 45.9 0.00036 XP_011520077 (OMIM: 616297) PREDICTED: multiple C2 ( 506) 233 45.9 0.00038 XP_016877892 (OMIM: 616297) PREDICTED: multiple C2 ( 866) 233 46.1 0.00057 XP_005255012 (OMIM: 616297) PREDICTED: multiple C2 ( 878) 233 46.1 0.00057 XP_006720666 (OMIM: 616297) PREDICTED: multiple C2 ( 878) 233 46.1 0.00057 NP_060819 (OMIM: 616297) multiple C2 and transmemb ( 878) 233 46.1 0.00057 XP_011520073 (OMIM: 616297) PREDICTED: multiple C2 ( 878) 233 46.1 0.00057 XP_011520074 (OMIM: 616297) PREDICTED: multiple C2 ( 878) 233 46.1 0.00057 >>XP_016884159 (OMIM: 613691) PREDICTED: GRAM domain-con (578 aa) initn: 3826 init1: 3826 opt: 3826 Z-score: 2969.9 bits: 559.5 E(85289): 1.1e-158 Smith-Waterman score: 3826; 100.0% identity (100.0% similar) in 578 aa overlap (1-578:1-578) 10 20 30 40 50 60 pF1KA0 MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIPLKVPRTSPRDSEELRDPAGPGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIPLKVPRTSPRDSEELRDPAGPGTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 IMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEELRKLREETNAEMLRQELDRERQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEELRKLREETNAEMLRQELDRERQR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 RMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAERRSQGLSSRLQKWFYERFGEYVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAERRSQGLSSRLQKWFYERFGEYVED 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 FRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSAIAFTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSAIAFTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 YMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRIQWSIVPEVSEPVEPPKEDLTVSEKFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRIQWSIVPEVSEPVEPPKEDLTVSEKFQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 VGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLPTDPQLKERSSAAVSRRLQTTSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLPTDPQLKERSSAAVSRRLQTTSSR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLTENERPLAVCENGWRCCLINRDRKMPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLTENERPLAVCENGWRCCLINRDRKMPT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 DYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLVDITDIQKYKVLSVLPGSGMGIAVSTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLVDITDIQKYKVLSVLPGSGMGIAVSTP 490 500 510 520 530 540 550 560 570 pF1KA0 STQKPLVFGAMVHRDEAFETILSQYIKITSAAASGGDS :::::::::::::::::::::::::::::::::::::: XP_016 STQKPLVFGAMVHRDEAFETILSQYIKITSAAASGGDS 550 560 570 >>XP_006724233 (OMIM: 613691) PREDICTED: GRAM domain-con (578 aa) initn: 3826 init1: 3826 opt: 3826 Z-score: 2969.9 bits: 559.5 E(85289): 1.1e-158 Smith-Waterman score: 3826; 100.0% identity (100.0% similar) in 578 aa overlap (1-578:1-578) 10 20 30 40 50 60 pF1KA0 MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIPLKVPRTSPRDSEELRDPAGPGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIPLKVPRTSPRDSEELRDPAGPGTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 IMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEELRKLREETNAEMLRQELDRERQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEELRKLREETNAEMLRQELDRERQR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 RMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAERRSQGLSSRLQKWFYERFGEYVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAERRSQGLSSRLQKWFYERFGEYVED 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 FRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSAIAFTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSAIAFTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 YMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRIQWSIVPEVSEPVEPPKEDLTVSEKFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRIQWSIVPEVSEPVEPPKEDLTVSEKFQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 VGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLPTDPQLKERSSAAVSRRLQTTSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLPTDPQLKERSSAAVSRRLQTTSSR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLTENERPLAVCENGWRCCLINRDRKMPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLTENERPLAVCENGWRCCLINRDRKMPT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 DYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLVDITDIQKYKVLSVLPGSGMGIAVSTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLVDITDIQKYKVLSVLPGSGMGIAVSTP 490 500 510 520 530 540 550 560 570 pF1KA0 STQKPLVFGAMVHRDEAFETILSQYIKITSAAASGGDS :::::::::::::::::::::::::::::::::::::: XP_006 STQKPLVFGAMVHRDEAFETILSQYIKITSAAASGGDS 550 560 570 >>NP_055939 (OMIM: 613691) GRAM domain-containing protei (578 aa) initn: 3826 init1: 3826 opt: 3826 Z-score: 2969.9 bits: 559.5 E(85289): 1.1e-158 Smith-Waterman score: 3826; 100.0% identity (100.0% similar) in 578 aa overlap (1-578:1-578) 10 20 30 40 50 60 pF1KA0 MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIPLKVPRTSPRDSEELRDPAGPGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIPLKVPRTSPRDSEELRDPAGPGTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 IMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEELRKLREETNAEMLRQELDRERQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 IMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEELRKLREETNAEMLRQELDRERQR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 RMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAERRSQGLSSRLQKWFYERFGEYVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAERRSQGLSSRLQKWFYERFGEYVED 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 FRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSAIAFTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 FRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSAIAFTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 YMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRIQWSIVPEVSEPVEPPKEDLTVSEKFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 YMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRIQWSIVPEVSEPVEPPKEDLTVSEKFQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 VGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLPTDPQLKERSSAAVSRRLQTTSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLPTDPQLKERSSAAVSRRLQTTSSR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLTENERPLAVCENGWRCCLINRDRKMPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLTENERPLAVCENGWRCCLINRDRKMPT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 DYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLVDITDIQKYKVLSVLPGSGMGIAVSTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLVDITDIQKYKVLSVLPGSGMGIAVSTP 490 500 510 520 530 540 550 560 570 pF1KA0 STQKPLVFGAMVHRDEAFETILSQYIKITSAAASGGDS :::::::::::::::::::::::::::::::::::::: NP_055 STQKPLVFGAMVHRDEAFETILSQYIKITSAAASGGDS 550 560 570 >>XP_006724232 (OMIM: 613691) PREDICTED: GRAM domain-con (601 aa) initn: 3826 init1: 3826 opt: 3826 Z-score: 2969.7 bits: 559.5 E(85289): 1.1e-158 Smith-Waterman score: 3826; 100.0% identity (100.0% similar) in 578 aa overlap (1-578:24-601) 10 20 30 pF1KA0 MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIP ::::::::::::::::::::::::::::::::::::: XP_006 MPVGLPREPERHVRVKQRTSVLNMLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIP 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 LKVPRTSPRDSEELRDPAGPGTLIMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LKVPRTSPRDSEELRDPAGPGTLIMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEE 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 LRKLREETNAEMLRQELDRERQRRMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LRKLREETNAEMLRQELDRERQRRMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAER 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA0 RSQGLSSRLQKWFYERFGEYVEDFRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RSQGLSSRLQKWFYERFGEYVEDFRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTN 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA0 FVKNLSALSDWYSVYTSAIAFTVYMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRIQWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FVKNLSALSDWYSVYTSAIAFTVYMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRIQWS 250 260 270 280 290 300 280 290 300 310 320 330 pF1KA0 IVPEVSEPVEPPKEDLTVSEKFQLVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IVPEVSEPVEPPKEDLTVSEKFQLVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQK 310 320 330 340 350 360 340 350 360 370 380 390 pF1KA0 LYVALWAAFLASCFFPYRLVGLAVGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LYVALWAAFLASCFFPYRLVGLAVGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLP 370 380 390 400 410 420 400 410 420 430 440 450 pF1KA0 TDPQLKERSSAAVSRRLQTTSSRSYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLTENE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TDPQLKERSSAAVSRRLQTTSSRSYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLTENE 430 440 450 460 470 480 460 470 480 490 500 510 pF1KA0 RPLAVCENGWRCCLINRDRKMPTDYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLVDIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RPLAVCENGWRCCLINRDRKMPTDYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLVDIT 490 500 510 520 530 540 520 530 540 550 560 570 pF1KA0 DIQKYKVLSVLPGSGMGIAVSTPSTQKPLVFGAMVHRDEAFETILSQYIKITSAAASGGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DIQKYKVLSVLPGSGMGIAVSTPSTQKPLVFGAMVHRDEAFETILSQYIKITSAAASGGD 550 560 570 580 590 600 pF1KA0 S : XP_006 S >>XP_005261453 (OMIM: 613691) PREDICTED: GRAM domain-con (604 aa) initn: 3826 init1: 3826 opt: 3826 Z-score: 2969.7 bits: 559.5 E(85289): 1.1e-158 Smith-Waterman score: 3826; 100.0% identity (100.0% similar) in 578 aa overlap (1-578:27-604) 10 20 30 pF1KA0 MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSD :::::::::::::::::::::::::::::::::: XP_005 MRVGPDIRSGEPERHVRVKQRTSVLNMLRRLDKIRFRGHKRDDFLDLAESPNASDTECSD 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 EIPLKVPRTSPRDSEELRDPAGPGTLIMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EIPLKVPRTSPRDSEELRDPAGPGTLIMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 QEELRKLREETNAEMLRQELDRERQRRMELEQKVQEVLKARTEEQMAQQPPKGQAQASNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QEELRKLREETNAEMLRQELDRERQRRMELEQKVQEVLKARTEEQMAQQPPKGQAQASNG 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA0 AERRSQGLSSRLQKWFYERFGEYVEDFRFQPEENTVETEEPLSARRLTENMRRLKRGAKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AERRSQGLSSRLQKWFYERFGEYVEDFRFQPEENTVETEEPLSARRLTENMRRLKRGAKP 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA0 VTNFVKNLSALSDWYSVYTSAIAFTVYMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VTNFVKNLSALSDWYSVYTSAIAFTVYMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRI 250 260 270 280 290 300 280 290 300 310 320 330 pF1KA0 QWSIVPEVSEPVEPPKEDLTVSEKFQLVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QWSIVPEVSEPVEPPKEDLTVSEKFQLVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEI 310 320 330 340 350 360 340 350 360 370 380 390 pF1KA0 TQKLYVALWAAFLASCFFPYRLVGLAVGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TQKLYVALWAAFLASCFFPYRLVGLAVGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWR 370 380 390 400 410 420 400 410 420 430 440 450 pF1KA0 SLPTDPQLKERSSAAVSRRLQTTSSRSYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLPTDPQLKERSSAAVSRRLQTTSSRSYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLT 430 440 450 460 470 480 460 470 480 490 500 510 pF1KA0 ENERPLAVCENGWRCCLINRDRKMPTDYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ENERPLAVCENGWRCCLINRDRKMPTDYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLV 490 500 510 520 530 540 520 530 540 550 560 570 pF1KA0 DITDIQKYKVLSVLPGSGMGIAVSTPSTQKPLVFGAMVHRDEAFETILSQYIKITSAAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DITDIQKYKVLSVLPGSGMGIAVSTPSTQKPLVFGAMVHRDEAFETILSQYIKITSAAAS 550 560 570 580 590 600 pF1KA0 GGDS :::: XP_005 GGDS >>XP_011528313 (OMIM: 613691) PREDICTED: GRAM domain-con (577 aa) initn: 3623 init1: 3623 opt: 3623 Z-score: 2813.2 bits: 530.5 E(85289): 5.9e-150 Smith-Waterman score: 3623; 100.0% identity (100.0% similar) in 545 aa overlap (1-545:1-545) 10 20 30 40 50 60 pF1KA0 MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIPLKVPRTSPRDSEELRDPAGPGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIPLKVPRTSPRDSEELRDPAGPGTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 IMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEELRKLREETNAEMLRQELDRERQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEELRKLREETNAEMLRQELDRERQR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 RMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAERRSQGLSSRLQKWFYERFGEYVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAERRSQGLSSRLQKWFYERFGEYVED 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 FRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSAIAFTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSAIAFTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 YMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRIQWSIVPEVSEPVEPPKEDLTVSEKFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRIQWSIVPEVSEPVEPPKEDLTVSEKFQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 VGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLPTDPQLKERSSAAVSRRLQTTSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLPTDPQLKERSSAAVSRRLQTTSSR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLTENERPLAVCENGWRCCLINRDRKMPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLTENERPLAVCENGWRCCLINRDRKMPT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 DYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLVDITDIQKYKVLSVLPGSGMGIAVSTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLVDITDIQKYKVLSVLPGSGMGIAVSTP 490 500 510 520 530 540 550 560 570 pF1KA0 STQKPLVFGAMVHRDEAFETILSQYIKITSAAASGGDS ::::: XP_011 STQKPGQRNLSSHPKRFSQPCVPLSRGQKLVHHQSHS 550 560 570 >>XP_011528314 (OMIM: 613691) PREDICTED: GRAM domain-con (555 aa) initn: 3470 init1: 3470 opt: 3473 Z-score: 2697.5 bits: 509.0 E(85289): 1.6e-143 Smith-Waterman score: 3627; 96.0% identity (96.0% similar) in 578 aa overlap (1-578:1-555) 10 20 30 40 50 60 pF1KA0 MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIPLKVPRTSPRDSEELRDPAGPGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIPLKVPRTSPRDSEELRDPAGPGTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 IMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEELRKLREETNAEMLRQELDRERQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEELRKLREETNAEMLRQELDRERQR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 RMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAERRSQGLSSRLQKWFYERFGEYVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAERRSQGLSSRLQKWFYERFGEYVED 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 FRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSAIAFTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSAIAFTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 YMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRIQWSIVPEVSEPVEPPKEDLTVSEKFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRIQWSIVPEVSEPVEPPKEDLTVSEKFQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 VGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLPTDPQLKERSSAAVSRRLQTTSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLPTDPQLKERSSAAVSRRLQTTSSR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLTENERPLAVCENGWRCCLINRDRKMPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLTENERPLAVCENGWRCCLINRDRKMPT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 DYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLVDITDIQKYKVLSVLPGSGMGIAVSTP ::::::::::::::::::::::::::::::::::::::::: XP_011 DYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLVDITDIQK------------------- 490 500 510 520 550 560 570 pF1KA0 STQKPLVFGAMVHRDEAFETILSQYIKITSAAASGGDS :::::::::::::::::::::::::::::::::: XP_011 ----PLVFGAMVHRDEAFETILSQYIKITSAAASGGDS 530 540 550 >>XP_011528315 (OMIM: 613691) PREDICTED: GRAM domain-con (561 aa) initn: 3470 init1: 3470 opt: 3470 Z-score: 2695.1 bits: 508.6 E(85289): 2.2e-143 Smith-Waterman score: 3470; 100.0% identity (100.0% similar) in 521 aa overlap (1-521:27-547) 10 20 30 pF1KA0 MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSD :::::::::::::::::::::::::::::::::: XP_011 MRVGPDIRSGEPERHVRVKQRTSVLNMLRRLDKIRFRGHKRDDFLDLAESPNASDTECSD 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 EIPLKVPRTSPRDSEELRDPAGPGTLIMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIPLKVPRTSPRDSEELRDPAGPGTLIMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 QEELRKLREETNAEMLRQELDRERQRRMELEQKVQEVLKARTEEQMAQQPPKGQAQASNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QEELRKLREETNAEMLRQELDRERQRRMELEQKVQEVLKARTEEQMAQQPPKGQAQASNG 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA0 AERRSQGLSSRLQKWFYERFGEYVEDFRFQPEENTVETEEPLSARRLTENMRRLKRGAKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AERRSQGLSSRLQKWFYERFGEYVEDFRFQPEENTVETEEPLSARRLTENMRRLKRGAKP 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA0 VTNFVKNLSALSDWYSVYTSAIAFTVYMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTNFVKNLSALSDWYSVYTSAIAFTVYMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRI 250 260 270 280 290 300 280 290 300 310 320 330 pF1KA0 QWSIVPEVSEPVEPPKEDLTVSEKFQLVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QWSIVPEVSEPVEPPKEDLTVSEKFQLVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEI 310 320 330 340 350 360 340 350 360 370 380 390 pF1KA0 TQKLYVALWAAFLASCFFPYRLVGLAVGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQKLYVALWAAFLASCFFPYRLVGLAVGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWR 370 380 390 400 410 420 400 410 420 430 440 450 pF1KA0 SLPTDPQLKERSSAAVSRRLQTTSSRSYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLPTDPQLKERSSAAVSRRLQTTSSRSYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLT 430 440 450 460 470 480 460 470 480 490 500 510 pF1KA0 ENERPLAVCENGWRCCLINRDRKMPTDYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENERPLAVCENGWRCCLINRDRKMPTDYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLV 490 500 510 520 530 540 520 530 540 550 560 570 pF1KA0 DITDIQKYKVLSVLPGSGMGIAVSTPSTQKPLVFGAMVHRDEAFETILSQYIKITSAAAS ::::::: XP_011 DITDIQKVNHHHRSVEAAGTK 550 560 >>XP_011528316 (OMIM: 613691) PREDICTED: GRAM domain-con (453 aa) initn: 2747 init1: 2747 opt: 2761 Z-score: 2148.7 bits: 407.2 E(85289): 6e-113 Smith-Waterman score: 2761; 94.0% identity (96.4% similar) in 450 aa overlap (1-447:1-448) 10 20 30 40 50 60 pF1KA0 MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIPLKVPRTSPRDSEELRDPAGPGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIPLKVPRTSPRDSEELRDPAGPGTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 IMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEELRKLREETNAEMLRQELDRERQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEELRKLREETNAEMLRQELDRERQR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 RMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAERRSQGLSSRLQKWFYERFGEYVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAERRSQGLSSRLQKWFYERFGEYVED 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 FRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSAIAFTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSAIAFTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 YMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRIQWSIVPEVSEPVEPPKEDLTVSEKFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRIQWSIVPEVSEPVEPPKEDLTVSEKFQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLA 310 320 330 340 350 360 370 380 390 400 410 pF1KA0 VGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLPTDPQLKERSSAAVSRR---LQTT ::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_011 VGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLPTDPQLKERSSAAVSRRSQALQMC 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA0 SSRSYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLTENERPLAVCENGWRCCLINRDRK :. : :. : :... . . : : ..:.. XP_011 STASQ-PG-PRGMSRPRCSLRGGSDESGGLLGSPH 430 440 450 >>XP_005255017 (OMIM: 616297) PREDICTED: multiple C2 and (466 aa) initn: 204 init1: 117 opt: 233 Z-score: 195.9 bits: 45.9 E(85289): 0.00036 Smith-Waterman score: 233; 29.5% identity (58.9% similar) in 190 aa overlap (183-363:226-413) 160 170 180 190 200 210 pF1KA0 NGAERRSQGLSSRLQKWFYERFGEYVEDFRFQPEENT-VETEEPLSARRLTENMRRLKRG : :.:. :: . :: . :.... :.:: XP_005 KNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRDVDRVKRI 200 210 220 230 240 250 220 230 240 250 260 pF1KA0 AKPVTNFVKNLSALSDWYSVYTSAIAFTVYMNAVWHG--WAIPLFLFLAILRLSLNYLIA . . : .. :.. .: :. :.:::.:.. .::. . ::: :.: .. . . . XP_005 TMAIWNTMQFLKSCFQWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYNFIRPVKG 260 270 280 290 300 310 270 280 290 300 310 320 pF1KA0 RGWRIQWSIVPEVSEPVEPPKEDLTVSEK------FQLVLDVAQKAQNLFGKMADILEKI . :: : : .. . :: ::: . .: :... .::.. ..:.. :.: XP_005 KVSSIQDS--QESTDIDDEEDEDDKESEKKGLIERIYMVQDIVSTVQNVLEEIASFGERI 320 330 340 350 360 370 330 340 350 360 370 380 pF1KA0 KNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLAVGLYAGIKFFLIDFIFKRCPRLR :: : :. : ... . : :: . :.: : . : :. XP_005 KNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDNNELLD 380 390 400 410 420 430 390 400 410 420 430 440 pF1KA0 AKYDTPYIIWRSLPTDPQLKERSSAAVSRRLQTTSSRSYVPSAPAGLGKEEDAGRFHSTK XP_005 FLSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL 440 450 460 578 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 00:59:15 2016 done: Fri Nov 4 00:59:16 2016 Total Scan time: 9.530 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]