Result of FASTA (omim) for pF1KA0790
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA0790, 1247 aa
  1>>>pF1KA0790 1247 - 1247 aa - 1247 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 12.4883+/-0.000425; mu= -10.4660+/- 0.027
 mean_var=397.8990+/-81.646, 0's: 0 Z-trim(122.9): 26  B-trim: 0 in 0/59
 Lambda= 0.064297
 statistics sampled from 41810 (41836) to 41810 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.777), E-opt: 0.2 (0.491), width:  16
 Scan time: 18.000

The best scores are:                                      opt bits E(85289)
NP_056093 (OMIM: 607955) SAM and SH3 domain-contai (1247) 8410 795.3       0
NP_001333434 (OMIM: 607955) SAM and SH3 domain-con (1202) 8030 760.0 2.1e-218
NP_001333435 (OMIM: 607955) SAM and SH3 domain-con (1123) 7525 713.1 2.5e-204
NP_001333436 (OMIM: 607955) SAM and SH3 domain-con (1008) 6747 640.9 1.2e-182
NP_001333438 (OMIM: 607955) SAM and SH3 domain-con (1130) 5710 544.8 1.2e-153
NP_001333437 (OMIM: 607955) SAM and SH3 domain-con (1171) 5710 544.8 1.3e-153
XP_016866094 (OMIM: 607955) PREDICTED: SAM and SH3 (1286) 5710 544.8 1.4e-153
XP_016866093 (OMIM: 607955) PREDICTED: SAM and SH3 (1291) 5710 544.8 1.4e-153
XP_016866091 (OMIM: 607955) PREDICTED: SAM and SH3 (1317) 5710 544.8 1.4e-153
XP_016866092 (OMIM: 607955) PREDICTED: SAM and SH3 (1317) 5710 544.8 1.4e-153
XP_016866090 (OMIM: 607955) PREDICTED: SAM and SH3 (1351) 5710 544.8 1.4e-153
XP_016866089 (OMIM: 607955) PREDICTED: SAM and SH3 (1365) 5710 544.8 1.4e-153
XP_016866088 (OMIM: 607955) PREDICTED: SAM and SH3 (1373) 5710 544.8 1.4e-153
XP_016866087 (OMIM: 607955) PREDICTED: SAM and SH3 (1410) 5710 544.8 1.5e-153
XP_011527986 (OMIM: 607978) PREDICTED: SAM domain- ( 355)  855 94.1 1.8e-18
NP_071419 (OMIM: 607978) SAM domain-containing pro ( 373)  855 94.1 1.9e-18
NP_001243299 (OMIM: 607978) SAM domain-containing  ( 441)  855 94.2 2.1e-18
NP_061863 (OMIM: 300441) SAM and SH3 domain-contai ( 380)  827 91.5 1.1e-17
NP_001273452 (OMIM: 607978) SAM domain-containing  ( 304)  793 88.3 8.5e-17
XP_011527988 (OMIM: 607978) PREDICTED: SAM domain- ( 309)  775 86.6 2.7e-16
XP_016883916 (OMIM: 607978) PREDICTED: SAM domain- ( 311)  773 86.5 3.1e-16
XP_011527987 (OMIM: 607978) PREDICTED: SAM domain- ( 323)  744 83.8 2.1e-15
XP_006724826 (OMIM: 300441) PREDICTED: SAM and SH3 ( 430)  568 67.5 2.2e-10


>>NP_056093 (OMIM: 607955) SAM and SH3 domain-containing  (1247 aa)
 initn: 8410 init1: 8410 opt: 8410  Z-score: 4232.3  bits: 795.3 E(85289):    0
Smith-Waterman score: 8410; 99.9% identity (100.0% similar) in 1247 aa overlap (1-1247:1-1247)

               10        20        30        40        50        60
pF1KA0 MEDAGAAGPGPEPEPEPEPEPEPAPEPEPEPKPGAGTSEAFSRLWTDVMGILDGSLGNID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MEDAGAAGPGPEPEPEPEPEPEPAPEPEPEPKPGAGTSEAFSRLWTDVMGILDGSLGNID
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 DLAQQYADYYNTCFSDVCERMEELRKRRVSQDLEVEKPDASPTSLQLRSQIEESLGFCSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DLAQQYADYYNTCFSDVCERMEELRKRRVSQDLEVEKPDASPTSLQLRSQIEESLGFCSA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 VSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVAS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 EITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSAALDPADWPDGSYPTFDGSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSAALDPADWPDGSYPTFDGSS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 NCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 NCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 DERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 GLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 GSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 DGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVK
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 SEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNN
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 KVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYE
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA0 DLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGC
       ::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::
NP_056 DLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGC
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA0 SPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQ
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA0 GQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSHSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSHSL
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA0 DDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSKRF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSKRF
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA0 SEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGT
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA0 HHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPCLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 HHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPCLP
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KA0 VKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLGPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLGPA
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KA0 LTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERD
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KA0 VAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTLST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTLST
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240       
pF1KA0 AGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
       :::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
             1210      1220      1230      1240       

>>NP_001333434 (OMIM: 607955) SAM and SH3 domain-contain  (1202 aa)
 initn: 8030 init1: 8030 opt: 8030  Z-score: 4042.0  bits: 760.0 E(85289): 2.1e-218
Smith-Waterman score: 8030; 99.9% identity (100.0% similar) in 1195 aa overlap (53-1247:8-1202)

             30        40        50        60        70        80  
pF1KA0 PAPEPEPEPKPGAGTSEAFSRLWTDVMGILDGSLGNIDDLAQQYADYYNTCFSDVCERME
                                     ::::::::::::::::::::::::::::::
NP_001                        MEEQDCRDGSLGNIDDLAQQYADYYNTCFSDVCERME
                                      10        20        30       

             90       100       110       120       130       140  
pF1KA0 ELRKRRVSQDLEVEKPDASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELRKRRVSQDLEVEKPDASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSV
        40        50        60        70        80        90       

            150       160       170       180       190       200  
pF1KA0 GKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMIT
       100       110       120       130       140       150       

            210       220       230       240       250       260  
pF1KA0 IEEALARLKEYEAQHRQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEEALARLKEYEAQHRQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLH
       160       170       180       190       200       210       

            270       280       290       300       310       320  
pF1KA0 KLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPE
       220       230       240       250       260       270       

            330       340       350       360       370       380  
pF1KA0 KPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQ
       280       290       300       310       320       330       

            390       400       410       420       430       440  
pF1KA0 KVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKS
       340       350       360       370       380       390       

            450       460       470       480       490       500  
pF1KA0 PTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKL
       400       410       420       430       440       450       

            510       520       530       540       550       560  
pF1KA0 KAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVH
       460       470       480       490       500       510       

            570       580       590       600       610       620  
pF1KA0 TDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKR
       520       530       540       550       560       570       

            630       640       650       660       670       680  
pF1KA0 PTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELKIRDPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::
NP_001 PTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPE
       580       590       600       610       620       630       

            690       700       710       720       730       740  
pF1KA0 HRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKA
       640       650       660       670       680       690       

            750       760       770       780       790       800  
pF1KA0 SLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPP
       700       710       720       730       740       750       

            810       820       830       840       850       860  
pF1KA0 GVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPP
       760       770       780       790       800       810       

            870       880       890       900       910       920  
pF1KA0 QIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGL
       820       830       840       850       860       870       

            930       940       950       960       970       980  
pF1KA0 SPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPS
       880       890       900       910       920       930       

            990      1000      1010      1020      1030      1040  
pF1KA0 QPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPR
       940       950       960       970       980       990       

           1050      1060      1070      1080      1090      1100  
pF1KA0 PLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLH
      1000      1010      1020      1030      1040      1050       

           1110      1120      1130      1140      1150      1160  
pF1KA0 AEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIP
      1060      1070      1080      1090      1100      1110       

           1170      1180      1190      1200      1210      1220  
pF1KA0 SGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGI
      1120      1130      1140      1150      1160      1170       

           1230      1240       
pF1KA0 TEERHIRKLLSAARLFKLPPGPEAM
       :::::::::::::::::::::::::
NP_001 TEERHIRKLLSAARLFKLPPGPEAM
      1180      1190      1200  

>>NP_001333435 (OMIM: 607955) SAM and SH3 domain-contain  (1123 aa)
 initn: 7525 init1: 7525 opt: 7525  Z-score: 3789.2  bits: 713.1 E(85289): 2.5e-204
Smith-Waterman score: 7525; 99.7% identity (100.0% similar) in 1120 aa overlap (128-1247:4-1123)

       100       110       120       130       140       150       
pF1KA0 PDASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQN
                                     ..::::::::::::::::::::::::::::
NP_001                            MLFQRNPLHKSNSEDSSVGKGDWKKKNKYFWQN
                                          10        20        30   

       160       170       180       190       200       210       
pF1KA0 FRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQH
            40        50        60        70        80        90   

       220       230       240       250       260       270       
pF1KA0 RQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIR
           100       110       120       130       140       150   

       280       290       300       310       320       330       
pF1KA0 VEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPS
           160       170       180       190       200       210   

       340       350       360       370       380       390       
pF1KA0 SSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGL
           220       230       240       250       260       270   

       400       410       420       430       440       450       
pF1KA0 GSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSV
           280       290       300       310       320       330   

       460       470       480       490       500       510       
pF1KA0 KETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSG
           340       350       360       370       380       390   

       520       530       540       550       560       570       
pF1KA0 QSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKL
           400       410       420       430       440       450   

       580       590       600       610       620       630       
pF1KA0 KKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKS
           460       470       480       490       500       510   

       640       650       660       670       680       690       
pF1KA0 VEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEY
       :::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::
NP_001 VEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEY
           520       530       540       550       560       570   

       700       710       720       730       740       750       
pF1KA0 DSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKS
           580       590       600       610       620       630   

       760       770       780       790       800       810       
pF1KA0 FSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVS
           640       650       660       670       680       690   

       820       830       840       850       860       870       
pF1KA0 ICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASST
           700       710       720       730       740       750   

       880       890       900       910       920       930       
pF1KA0 KAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPP
           760       770       780       790       800       810   

       940       950       960       970       980       990       
pF1KA0 GAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLA
           820       830       840       850       860       870   

      1000      1010      1020      1030      1040      1050       
pF1KA0 NGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRP
           880       890       900       910       920       930   

      1060      1070      1080      1090      1100      1110       
pF1KA0 PPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKH
           940       950       960       970       980       990   

      1120      1130      1140      1150      1160      1170       
pF1KA0 GRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPG
          1000      1010      1020      1030      1040      1050   

      1180      1190      1200      1210      1220      1230       
pF1KA0 CISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARL
          1060      1070      1080      1090      1100      1110   

      1240       
pF1KA0 FKLPPGPEAM
       ::::::::::
NP_001 FKLPPGPEAM
          1120   

>>NP_001333436 (OMIM: 607955) SAM and SH3 domain-contain  (1008 aa)
 initn: 6747 init1: 6747 opt: 6747  Z-score: 3399.9  bits: 640.9 E(85289): 1.2e-182
Smith-Waterman score: 6747; 99.9% identity (100.0% similar) in 1004 aa overlap (244-1247:5-1008)

           220       230       240       250       260       270   
pF1KA0 EAQHRQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRK
                                     ::::::::::::::::::::::::::::::
NP_001                           MPKPSREQSDDETEESVKFKRLHKLVNSTRRVRK
                                         10        20        30    

           280       290       300       310       320       330   
pF1KA0 KLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLT
           40        50        60        70        80        90    

           340       350       360       370       380       390   
pF1KA0 TSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEM
          100       110       120       130       140       150    

           400       410       420       430       440       450   
pF1KA0 KKGLGSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKGLGSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKK
          160       170       180       190       200       210    

           460       470       480       490       500       510   
pF1KA0 VKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRS
          220       230       240       250       260       270    

           520       530       540       550       560       570   
pF1KA0 SLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTD
          280       290       300       310       320       330    

           580       590       600       610       620       630   
pF1KA0 SLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPP
          340       350       360       370       380       390    

           640       650       660       670       680       690   
pF1KA0 QPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVEL
       :::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::
NP_001 QPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVEL
          400       410       420       430       440       450    

           700       710       720       730       740       750   
pF1KA0 LQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEP
          460       470       480       490       500       510    

           760       770       780       790       800       810   
pF1KA0 SLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRS
          520       530       540       550       560       570    

           820       830       840       850       860       870   
pF1KA0 LPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTT
          580       590       600       610       620       630    

           880       890       900       910       920       930   
pF1KA0 ASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYD
          640       650       660       670       680       690    

           940       950       960       970       980       990   
pF1KA0 AQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSR
          700       710       720       730       740       750    

          1000      1010      1020      1030      1040      1050   
pF1KA0 ERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPP
          760       770       780       790       800       810    

          1060      1070      1080      1090      1100      1110   
pF1KA0 STRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPY
          820       830       840       850       860       870    

          1120      1130      1140      1150      1160      1170   
pF1KA0 SDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKP
          880       890       900       910       920       930    

          1180      1190      1200      1210      1220      1230   
pF1KA0 VSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLS
          940       950       960       970       980       990    

          1240       
pF1KA0 AARLFKLPPGPEAM
       ::::::::::::::
NP_001 AARLFKLPPGPEAM
         1000        

>>NP_001333438 (OMIM: 607955) SAM and SH3 domain-contain  (1130 aa)
 initn: 5707 init1: 5707 opt: 5710  Z-score: 2879.3  bits: 544.8 E(85289): 1.2e-153
Smith-Waterman score: 6185; 85.5% identity (85.6% similar) in 1130 aa overlap (281-1247:1-1130)

              260       270       280       290       300       310
pF1KA0 ETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGV
                                     ::::::::::::::::::::::::::::::
NP_001                               MKKPSTEGGEEHVFENSPVLDERSALYSGV
                                             10        20        30

              320       330       340       350       360       370
pF1KA0 HKKPLFFDGSPEKPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKKPLFFDGSPEKPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMG
               40        50        60        70        80        90

              380       390       400                              
pF1KA0 TFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHG---------------------------
       :::::::::::::::::::::::::::::::::                           
NP_001 TFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHGVSTDGVCFYDNHRRRHHLLVSLEEFQS
              100       110       120       130       140       150

                                                                   
pF1KA0 ------------------------------------------------------------
                                                                   
NP_001 VRKQIRLKKTDTNYSCSRAFLCQRPSRKGVTSTTCDLQLLRQKGKGGGSCGFPGRRVRGR
              160       170       180       190       200       210

                                                                   
pF1KA0 ------------------------------------------------------------
                                                                   
NP_001 TSVSEFNITYVVERSLYSHLNLTQLVRPASDRTLSKAERQDLRRCLLEEDEEAKRKWAAT
              220       230       240       250       260       270

                           410       420       430       440       
pF1KA0 ----------------RTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASR
                       ::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDRCTKRVLLRIHQKSRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASR
              280       290       300       310       320       330

       450       460       470       480       490       500       
pF1KA0 ISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGS
              340       350       360       370       380       390

       510       520       530       540       550       560       
pF1KA0 VESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTP
              400       410       420       430       440       450

       570       580       590       600       610       620       
pF1KA0 SPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRR
              460       470       480       490       500       510

       630       640       650       660       670       680       
pF1KA0 RKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELKIRDPEHRAVL
       :::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
NP_001 RKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVL
              520       530       540       550       560       570

       690       700       710       720       730       740       
pF1KA0 LTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSA
              580       590       600       610       620       630

       750       760       770       780       790       800       
pF1KA0 KSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGL
              640       650       660       670       680       690

       810       820       830       840       850       860       
pF1KA0 NKNRRSLPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKNRRSLPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPE
              700       710       720       730       740       750

       870       880       890       900       910       920       
pF1KA0 VPQKTTASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPQKTTASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQC
              760       770       780       790       800       810

       930       940       950       960       970       980       
pF1KA0 LPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPV
              820       830       840       850       860       870

       990      1000      1010      1020      1030      1040       
pF1KA0 PAKKSRERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAKKSRERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQ
              880       890       900       910       920       930

      1050      1060      1070      1080      1090      1100       
pF1KA0 APGSPPSTRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APGSPPSTRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGID
              940       950       960       970       980       990

      1110      1120      1130      1140      1150      1160       
pF1KA0 LTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLT
             1000      1010      1020      1030      1040      1050

      1170      1180      1190      1200      1210      1220       
pF1KA0 EICRKPVSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EICRKPVSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERH
             1060      1070      1080      1090      1100      1110

      1230      1240       
pF1KA0 IRKLLSAARLFKLPPGPEAM
       ::::::::::::::::::::
NP_001 IRKLLSAARLFKLPPGPEAM
             1120      1130

>>NP_001333437 (OMIM: 607955) SAM and SH3 domain-contain  (1171 aa)
 initn: 5707 init1: 5707 opt: 5710  Z-score: 2879.1  bits: 544.8 E(85289): 1.3e-153
Smith-Waterman score: 6411; 85.9% identity (86.0% similar) in 1167 aa overlap (244-1247:5-1171)

           220       230       240       250       260       270   
pF1KA0 EAQHRQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRK
                                     ::::::::::::::::::::::::::::::
NP_001                           MPKPSREQSDDETEESVKFKRLHKLVNSTRRVRK
                                         10        20        30    

           280       290       300       310       320       330   
pF1KA0 KLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLT
           40        50        60        70        80        90    

           340       350       360       370       380       390   
pF1KA0 TSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEM
          100       110       120       130       140       150    

           400                                                     
pF1KA0 KKGLGSLSHG--------------------------------------------------
       ::::::::::                                                  
NP_001 KKGLGSLSHGVSTDGVCFYDNHRRRHHLLVSLEEFQSVRKQIRLKKTDTNYSCSRAFLCQ
          160       170       180       190       200       210    

                                                                   
pF1KA0 ------------------------------------------------------------
                                                                   
NP_001 RPSRKGVTSTTCDLQLLRQKGKGGGSCGFPGRRVRGRTSVSEFNITYVVERSLYSHLNLT
          220       230       240       250       260       270    

                                                                410
pF1KA0 -----------------------------------------------------RTCSFGG
                                                            :::::::
NP_001 QLVRPASDRTLSKAERQDLRRCLLEEDEEAKRKWAATVDRCTKRVLLRIHQKSRTCSFGG
          280       290       300       310       320       330    

              420       430       440       450       460       470
pF1KA0 FDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYS
          340       350       360       370       380       390    

              480       490       500       510       520       530
pF1KA0 SSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTD
          400       410       420       430       440       450    

              540       550       560       570       580       590
pF1KA0 SSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPP
          460       470       480       490       500       510    

              600       610       620       630       640       650
pF1KA0 MGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEH
          520       530       540       550       560       570    

              660       670       680       690       700       710
pF1KA0 MPTFLFNGYEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKL
       ::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::
NP_001 MPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKL
          580       590       600       610       620       630    

              720       730       740       750       760       770
pF1KA0 LVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLP
          640       650       660       670       680       690    

              780       790       800       810       820       830
pF1KA0 LMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQT
          700       710       720       730       740       750    

              840       850       860       870       880       890
pF1KA0 VDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDN
          760       770       780       790       800       810    

              900       910       920       930       940       950
pF1KA0 ALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEG
          820       830       840       850       860       870    

              960       970       980       990      1000      1010
pF1KA0 HRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGA
          880       890       900       910       920       930    

             1020      1030      1040      1050      1060      1070
pF1KA0 LPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSL
          940       950       960       970       980       990    

             1080      1090      1100      1110      1120      1130
pF1KA0 QEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRY
         1000      1010      1020      1030      1040      1050    

             1140      1150      1160      1170      1180      1190
pF1KA0 AEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIG
         1060      1070      1080      1090      1100      1110    

             1200      1210      1220      1230      1240       
pF1KA0 LPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
         1120      1130      1140      1150      1160      1170 

>>XP_016866094 (OMIM: 607955) PREDICTED: SAM and SH3 dom  (1286 aa)
 initn: 5707 init1: 5707 opt: 5710  Z-score: 2878.5  bits: 544.8 E(85289): 1.4e-153
Smith-Waterman score: 7168; 87.2% identity (87.3% similar) in 1279 aa overlap (132-1247:8-1286)

             110       120       130       140       150       160 
pF1KA0 PTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN
                                     ::::::::::::::::::::::::::::::
XP_016                        MLFQRNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN
                                      10        20        30       

             170       180       190       200       210       220 
pF1KA0 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA
        40        50        60        70        80        90       

             230       240       250       260       270       280 
pF1KA0 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM
       100       110       120       130       140       150       

             290       300       310       320       330       340 
pF1KA0 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL
       160       170       180       190       200       210       

             350       360       370       380       390       400 
pF1KA0 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS
       220       230       240       250       260       270       

                                                                   
pF1KA0 HG----------------------------------------------------------
       ::                                                          
XP_016 HGVSTDGVCFYDNHRRRHHLLVSLEEFQSVRKQIRLKKTDTNYSCSRAFLCQRPSRKGVT
       280       290       300       310       320       330       

                                                                   
pF1KA0 ------------------------------------------------------------
                                                                   
XP_016 STTCDLQLLRQKGKGGGSCGFPGRRVRGRTSVSEFNITYVVERSLYSHLNLTQLVRPASD
       340       350       360       370       380       390       

                                                        410        
pF1KA0 ---------------------------------------------RTCSFGGFDLTNRSL
                                                    :::::::::::::::
XP_016 RTLSKAERQDLRRCLLEEDEEAKRKWAATVDRCTKRVLLRIHQKSRTCSFGGFDLTNRSL
       400       410       420       430       440       450       

      420       430       440       450       460       470        
pF1KA0 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS
       460       470       480       490       500       510       

      480       490       500       510       520       530        
pF1KA0 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES
       520       530       540       550       560       570       

      540       550       560       570       580       590        
pF1KA0 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL
       580       590       600       610       620       630       

      600       610       620       630       640       650        
pF1KA0 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG
       640       650       660       670       680       690       

      660       670       680       690       700       710        
pF1KA0 YEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS
       ::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::
XP_016 YEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS
       700       710       720       730       740       750       

      720       730       740       750       760       770        
pF1KA0 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL
       760       770       780       790       800       810       

      780       790       800       810       820       830        
pF1KA0 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH
       820       830       840       850       860       870       

      840       850       860       870       880       890        
pF1KA0 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK
       880       890       900       910       920       930       

      900       910       920       930       940       950        
pF1KA0 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE
       940       950       960       970       980       990       

      960       970       980       990      1000      1010        
pF1KA0 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC
      1000      1010      1020      1030      1040      1050       

     1020      1030      1040      1050      1060      1070        
pF1KA0 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG
      1060      1070      1080      1090      1100      1110       

     1080      1090      1100      1110      1120      1130        
pF1KA0 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE
      1120      1130      1140      1150      1160      1170       

     1140      1150      1160      1170      1180      1190        
pF1KA0 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL
      1180      1190      1200      1210      1220      1230       

     1200      1210      1220      1230      1240       
pF1KA0 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
       :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
      1240      1250      1260      1270      1280      

>>XP_016866093 (OMIM: 607955) PREDICTED: SAM and SH3 dom  (1291 aa)
 initn: 5707 init1: 5707 opt: 5710  Z-score: 2878.5  bits: 544.8 E(85289): 1.4e-153
Smith-Waterman score: 7168; 87.2% identity (87.3% similar) in 1279 aa overlap (132-1247:13-1291)

             110       120       130       140       150       160 
pF1KA0 PTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN
                                     ::::::::::::::::::::::::::::::
XP_016                   MLTEIKQAIMNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN
                                 10        20        30        40  

             170       180       190       200       210       220 
pF1KA0 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA
             50        60        70        80        90       100  

             230       240       250       260       270       280 
pF1KA0 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM
            110       120       130       140       150       160  

             290       300       310       320       330       340 
pF1KA0 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL
            170       180       190       200       210       220  

             350       360       370       380       390       400 
pF1KA0 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS
            230       240       250       260       270       280  

                                                                   
pF1KA0 HG----------------------------------------------------------
       ::                                                          
XP_016 HGVSTDGVCFYDNHRRRHHLLVSLEEFQSVRKQIRLKKTDTNYSCSRAFLCQRPSRKGVT
            290       300       310       320       330       340  

                                                                   
pF1KA0 ------------------------------------------------------------
                                                                   
XP_016 STTCDLQLLRQKGKGGGSCGFPGRRVRGRTSVSEFNITYVVERSLYSHLNLTQLVRPASD
            350       360       370       380       390       400  

                                                        410        
pF1KA0 ---------------------------------------------RTCSFGGFDLTNRSL
                                                    :::::::::::::::
XP_016 RTLSKAERQDLRRCLLEEDEEAKRKWAATVDRCTKRVLLRIHQKSRTCSFGGFDLTNRSL
            410       420       430       440       450       460  

      420       430       440       450       460       470        
pF1KA0 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS
            470       480       490       500       510       520  

      480       490       500       510       520       530        
pF1KA0 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES
            530       540       550       560       570       580  

      540       550       560       570       580       590        
pF1KA0 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL
            590       600       610       620       630       640  

      600       610       620       630       640       650        
pF1KA0 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG
            650       660       670       680       690       700  

      660       670       680       690       700       710        
pF1KA0 YEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS
       ::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::
XP_016 YEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS
            710       720       730       740       750       760  

      720       730       740       750       760       770        
pF1KA0 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL
            770       780       790       800       810       820  

      780       790       800       810       820       830        
pF1KA0 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH
            830       840       850       860       870       880  

      840       850       860       870       880       890        
pF1KA0 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK
            890       900       910       920       930       940  

      900       910       920       930       940       950        
pF1KA0 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE
            950       960       970       980       990      1000  

      960       970       980       990      1000      1010        
pF1KA0 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC
           1010      1020      1030      1040      1050      1060  

     1020      1030      1040      1050      1060      1070        
pF1KA0 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG
           1070      1080      1090      1100      1110      1120  

     1080      1090      1100      1110      1120      1130        
pF1KA0 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE
           1130      1140      1150      1160      1170      1180  

     1140      1150      1160      1170      1180      1190        
pF1KA0 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL
           1190      1200      1210      1220      1230      1240  

     1200      1210      1220      1230      1240       
pF1KA0 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
       :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
           1250      1260      1270      1280      1290 

>>XP_016866091 (OMIM: 607955) PREDICTED: SAM and SH3 dom  (1317 aa)
 initn: 5707 init1: 5707 opt: 5710  Z-score: 2878.4  bits: 544.8 E(85289): 1.4e-153
Smith-Waterman score: 7168; 87.2% identity (87.3% similar) in 1279 aa overlap (132-1247:39-1317)

             110       120       130       140       150       160 
pF1KA0 PTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN
                                     ::::::::::::::::::::::::::::::
XP_016 IITTPVSPTCARGWRSCGNGGFPRTWKWNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN
       10        20        30        40        50        60        

             170       180       190       200       210       220 
pF1KA0 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA
       70        80        90       100       110       120        

             230       240       250       260       270       280 
pF1KA0 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM
      130       140       150       160       170       180        

             290       300       310       320       330       340 
pF1KA0 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL
      190       200       210       220       230       240        

             350       360       370       380       390       400 
pF1KA0 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS
      250       260       270       280       290       300        

                                                                   
pF1KA0 HG----------------------------------------------------------
       ::                                                          
XP_016 HGVSTDGVCFYDNHRRRHHLLVSLEEFQSVRKQIRLKKTDTNYSCSRAFLCQRPSRKGVT
      310       320       330       340       350       360        

                                                                   
pF1KA0 ------------------------------------------------------------
                                                                   
XP_016 STTCDLQLLRQKGKGGGSCGFPGRRVRGRTSVSEFNITYVVERSLYSHLNLTQLVRPASD
      370       380       390       400       410       420        

                                                        410        
pF1KA0 ---------------------------------------------RTCSFGGFDLTNRSL
                                                    :::::::::::::::
XP_016 RTLSKAERQDLRRCLLEEDEEAKRKWAATVDRCTKRVLLRIHQKSRTCSFGGFDLTNRSL
      430       440       450       460       470       480        

      420       430       440       450       460       470        
pF1KA0 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS
      490       500       510       520       530       540        

      480       490       500       510       520       530        
pF1KA0 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES
      550       560       570       580       590       600        

      540       550       560       570       580       590        
pF1KA0 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL
      610       620       630       640       650       660        

      600       610       620       630       640       650        
pF1KA0 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG
      670       680       690       700       710       720        

      660       670       680       690       700       710        
pF1KA0 YEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS
       ::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::
XP_016 YEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS
      730       740       750       760       770       780        

      720       730       740       750       760       770        
pF1KA0 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL
      790       800       810       820       830       840        

      780       790       800       810       820       830        
pF1KA0 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH
      850       860       870       880       890       900        

      840       850       860       870       880       890        
pF1KA0 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK
      910       920       930       940       950       960        

      900       910       920       930       940       950        
pF1KA0 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE
      970       980       990      1000      1010      1020        

      960       970       980       990      1000      1010        
pF1KA0 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC
     1030      1040      1050      1060      1070      1080        

     1020      1030      1040      1050      1060      1070        
pF1KA0 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG
     1090      1100      1110      1120      1130      1140        

     1080      1090      1100      1110      1120      1130        
pF1KA0 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE
     1150      1160      1170      1180      1190      1200        

     1140      1150      1160      1170      1180      1190        
pF1KA0 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL
     1210      1220      1230      1240      1250      1260        

     1200      1210      1220      1230      1240       
pF1KA0 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
       :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
     1270      1280      1290      1300      1310       

>>XP_016866092 (OMIM: 607955) PREDICTED: SAM and SH3 dom  (1317 aa)
 initn: 5707 init1: 5707 opt: 5710  Z-score: 2878.4  bits: 544.8 E(85289): 1.4e-153
Smith-Waterman score: 7168; 87.2% identity (87.3% similar) in 1279 aa overlap (132-1247:39-1317)

             110       120       130       140       150       160 
pF1KA0 PTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN
                                     ::::::::::::::::::::::::::::::
XP_016 IITTPVSPTCARGWRSCGNGGFPRTWKWNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN
       10        20        30        40        50        60        

             170       180       190       200       210       220 
pF1KA0 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA
       70        80        90       100       110       120        

             230       240       250       260       270       280 
pF1KA0 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM
      130       140       150       160       170       180        

             290       300       310       320       330       340 
pF1KA0 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL
      190       200       210       220       230       240        

             350       360       370       380       390       400 
pF1KA0 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS
      250       260       270       280       290       300        

                                                                   
pF1KA0 HG----------------------------------------------------------
       ::                                                          
XP_016 HGVSTDGVCFYDNHRRRHHLLVSLEEFQSVRKQIRLKKTDTNYSCSRAFLCQRPSRKGVT
      310       320       330       340       350       360        

                                                                   
pF1KA0 ------------------------------------------------------------
                                                                   
XP_016 STTCDLQLLRQKGKGGGSCGFPGRRVRGRTSVSEFNITYVVERSLYSHLNLTQLVRPASD
      370       380       390       400       410       420        

                                                        410        
pF1KA0 ---------------------------------------------RTCSFGGFDLTNRSL
                                                    :::::::::::::::
XP_016 RTLSKAERQDLRRCLLEEDEEAKRKWAATVDRCTKRVLLRIHQKSRTCSFGGFDLTNRSL
      430       440       450       460       470       480        

      420       430       440       450       460       470        
pF1KA0 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS
      490       500       510       520       530       540        

      480       490       500       510       520       530        
pF1KA0 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES
      550       560       570       580       590       600        

      540       550       560       570       580       590        
pF1KA0 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL
      610       620       630       640       650       660        

      600       610       620       630       640       650        
pF1KA0 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG
      670       680       690       700       710       720        

      660       670       680       690       700       710        
pF1KA0 YEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS
       ::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::
XP_016 YEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS
      730       740       750       760       770       780        

      720       730       740       750       760       770        
pF1KA0 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL
      790       800       810       820       830       840        

      780       790       800       810       820       830        
pF1KA0 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH
      850       860       870       880       890       900        

      840       850       860       870       880       890        
pF1KA0 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK
      910       920       930       940       950       960        

      900       910       920       930       940       950        
pF1KA0 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE
      970       980       990      1000      1010      1020        

      960       970       980       990      1000      1010        
pF1KA0 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC
     1030      1040      1050      1060      1070      1080        

     1020      1030      1040      1050      1060      1070        
pF1KA0 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG
     1090      1100      1110      1120      1130      1140        

     1080      1090      1100      1110      1120      1130        
pF1KA0 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE
     1150      1160      1170      1180      1190      1200        

     1140      1150      1160      1170      1180      1190        
pF1KA0 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL
     1210      1220      1230      1240      1250      1260        

     1200      1210      1220      1230      1240       
pF1KA0 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
       :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
     1270      1280      1290      1300      1310       




1247 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 01:01:19 2016 done: Fri Nov  4 01:01:22 2016
 Total Scan time: 18.000 Total Display time:  0.600

Function used was FASTA [36.3.4 Apr, 2011]
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