FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0790, 1247 aa 1>>>pF1KA0790 1247 - 1247 aa - 1247 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.4883+/-0.000425; mu= -10.4660+/- 0.027 mean_var=397.8990+/-81.646, 0's: 0 Z-trim(122.9): 26 B-trim: 0 in 0/59 Lambda= 0.064297 statistics sampled from 41810 (41836) to 41810 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.777), E-opt: 0.2 (0.491), width: 16 Scan time: 18.000 The best scores are: opt bits E(85289) NP_056093 (OMIM: 607955) SAM and SH3 domain-contai (1247) 8410 795.3 0 NP_001333434 (OMIM: 607955) SAM and SH3 domain-con (1202) 8030 760.0 2.1e-218 NP_001333435 (OMIM: 607955) SAM and SH3 domain-con (1123) 7525 713.1 2.5e-204 NP_001333436 (OMIM: 607955) SAM and SH3 domain-con (1008) 6747 640.9 1.2e-182 NP_001333438 (OMIM: 607955) SAM and SH3 domain-con (1130) 5710 544.8 1.2e-153 NP_001333437 (OMIM: 607955) SAM and SH3 domain-con (1171) 5710 544.8 1.3e-153 XP_016866094 (OMIM: 607955) PREDICTED: SAM and SH3 (1286) 5710 544.8 1.4e-153 XP_016866093 (OMIM: 607955) PREDICTED: SAM and SH3 (1291) 5710 544.8 1.4e-153 XP_016866091 (OMIM: 607955) PREDICTED: SAM and SH3 (1317) 5710 544.8 1.4e-153 XP_016866092 (OMIM: 607955) PREDICTED: SAM and SH3 (1317) 5710 544.8 1.4e-153 XP_016866090 (OMIM: 607955) PREDICTED: SAM and SH3 (1351) 5710 544.8 1.4e-153 XP_016866089 (OMIM: 607955) PREDICTED: SAM and SH3 (1365) 5710 544.8 1.4e-153 XP_016866088 (OMIM: 607955) PREDICTED: SAM and SH3 (1373) 5710 544.8 1.4e-153 XP_016866087 (OMIM: 607955) PREDICTED: SAM and SH3 (1410) 5710 544.8 1.5e-153 XP_011527986 (OMIM: 607978) PREDICTED: SAM domain- ( 355) 855 94.1 1.8e-18 NP_071419 (OMIM: 607978) SAM domain-containing pro ( 373) 855 94.1 1.9e-18 NP_001243299 (OMIM: 607978) SAM domain-containing ( 441) 855 94.2 2.1e-18 NP_061863 (OMIM: 300441) SAM and SH3 domain-contai ( 380) 827 91.5 1.1e-17 NP_001273452 (OMIM: 607978) SAM domain-containing ( 304) 793 88.3 8.5e-17 XP_011527988 (OMIM: 607978) PREDICTED: SAM domain- ( 309) 775 86.6 2.7e-16 XP_016883916 (OMIM: 607978) PREDICTED: SAM domain- ( 311) 773 86.5 3.1e-16 XP_011527987 (OMIM: 607978) PREDICTED: SAM domain- ( 323) 744 83.8 2.1e-15 XP_006724826 (OMIM: 300441) PREDICTED: SAM and SH3 ( 430) 568 67.5 2.2e-10 >>NP_056093 (OMIM: 607955) SAM and SH3 domain-containing (1247 aa) initn: 8410 init1: 8410 opt: 8410 Z-score: 4232.3 bits: 795.3 E(85289): 0 Smith-Waterman score: 8410; 99.9% identity (100.0% similar) in 1247 aa overlap (1-1247:1-1247) 10 20 30 40 50 60 pF1KA0 MEDAGAAGPGPEPEPEPEPEPEPAPEPEPEPKPGAGTSEAFSRLWTDVMGILDGSLGNID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MEDAGAAGPGPEPEPEPEPEPEPAPEPEPEPKPGAGTSEAFSRLWTDVMGILDGSLGNID 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 DLAQQYADYYNTCFSDVCERMEELRKRRVSQDLEVEKPDASPTSLQLRSQIEESLGFCSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 DLAQQYADYYNTCFSDVCERMEELRKRRVSQDLEVEKPDASPTSLQLRSQIEESLGFCSA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 VSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 VSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVAS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 EITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSAALDPADWPDGSYPTFDGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 EITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSAALDPADWPDGSYPTFDGSS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 NCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 NCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 DERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 DERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 GLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 GSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 DGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 DGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 KVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 DLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGC ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: NP_056 DLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 SPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 GQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSHSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSHSL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 DDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSKRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 DDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSKRF 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 SEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGT 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 HHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPCLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 HHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPCLP 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 VKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLGPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 VKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLGPA 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 LTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERD 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 VAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTLST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 VAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTLST 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 pF1KA0 AGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM ::::::::::::::::::::::::::::::::::::::::::::::: NP_056 AGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM 1210 1220 1230 1240 >>NP_001333434 (OMIM: 607955) SAM and SH3 domain-contain (1202 aa) initn: 8030 init1: 8030 opt: 8030 Z-score: 4042.0 bits: 760.0 E(85289): 2.1e-218 Smith-Waterman score: 8030; 99.9% identity (100.0% similar) in 1195 aa overlap (53-1247:8-1202) 30 40 50 60 70 80 pF1KA0 PAPEPEPEPKPGAGTSEAFSRLWTDVMGILDGSLGNIDDLAQQYADYYNTCFSDVCERME :::::::::::::::::::::::::::::: NP_001 MEEQDCRDGSLGNIDDLAQQYADYYNTCFSDVCERME 10 20 30 90 100 110 120 130 140 pF1KA0 ELRKRRVSQDLEVEKPDASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELRKRRVSQDLEVEKPDASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSV 40 50 60 70 80 90 150 160 170 180 190 200 pF1KA0 GKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMIT 100 110 120 130 140 150 210 220 230 240 250 260 pF1KA0 IEEALARLKEYEAQHRQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEEALARLKEYEAQHRQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLH 160 170 180 190 200 210 270 280 290 300 310 320 pF1KA0 KLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPE 220 230 240 250 260 270 330 340 350 360 370 380 pF1KA0 KPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQ 280 290 300 310 320 330 390 400 410 420 430 440 pF1KA0 KVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKS 340 350 360 370 380 390 450 460 470 480 490 500 pF1KA0 PTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKL 400 410 420 430 440 450 510 520 530 540 550 560 pF1KA0 KAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVH 460 470 480 490 500 510 570 580 590 600 610 620 pF1KA0 TDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKR 520 530 540 550 560 570 630 640 650 660 670 680 pF1KA0 PTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELKIRDPE ::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::: NP_001 PTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPE 580 590 600 610 620 630 690 700 710 720 730 740 pF1KA0 HRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKA 640 650 660 670 680 690 750 760 770 780 790 800 pF1KA0 SLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPP 700 710 720 730 740 750 810 820 830 840 850 860 pF1KA0 GVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPP 760 770 780 790 800 810 870 880 890 900 910 920 pF1KA0 QIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGL 820 830 840 850 860 870 930 940 950 960 970 980 pF1KA0 SPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPS 880 890 900 910 920 930 990 1000 1010 1020 1030 1040 pF1KA0 QPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPR 940 950 960 970 980 990 1050 1060 1070 1080 1090 1100 pF1KA0 PLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLH 1000 1010 1020 1030 1040 1050 1110 1120 1130 1140 1150 1160 pF1KA0 AEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIP 1060 1070 1080 1090 1100 1110 1170 1180 1190 1200 1210 1220 pF1KA0 SGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGI 1120 1130 1140 1150 1160 1170 1230 1240 pF1KA0 TEERHIRKLLSAARLFKLPPGPEAM ::::::::::::::::::::::::: NP_001 TEERHIRKLLSAARLFKLPPGPEAM 1180 1190 1200 >>NP_001333435 (OMIM: 607955) SAM and SH3 domain-contain (1123 aa) initn: 7525 init1: 7525 opt: 7525 Z-score: 3789.2 bits: 713.1 E(85289): 2.5e-204 Smith-Waterman score: 7525; 99.7% identity (100.0% similar) in 1120 aa overlap (128-1247:4-1123) 100 110 120 130 140 150 pF1KA0 PDASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQN ..:::::::::::::::::::::::::::: NP_001 MLFQRNPLHKSNSEDSSVGKGDWKKKNKYFWQN 10 20 30 160 170 180 190 200 210 pF1KA0 FRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQH 40 50 60 70 80 90 220 230 240 250 260 270 pF1KA0 RQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIR 100 110 120 130 140 150 280 290 300 310 320 330 pF1KA0 VEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPS 160 170 180 190 200 210 340 350 360 370 380 390 pF1KA0 SSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGL 220 230 240 250 260 270 400 410 420 430 440 450 pF1KA0 GSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSV 280 290 300 310 320 330 460 470 480 490 500 510 pF1KA0 KETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSG 340 350 360 370 380 390 520 530 540 550 560 570 pF1KA0 QSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKL 400 410 420 430 440 450 580 590 600 610 620 630 pF1KA0 KKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKS 460 470 480 490 500 510 640 650 660 670 680 690 pF1KA0 VEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEY :::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::: NP_001 VEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEY 520 530 540 550 560 570 700 710 720 730 740 750 pF1KA0 DSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKS 580 590 600 610 620 630 760 770 780 790 800 810 pF1KA0 FSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVS 640 650 660 670 680 690 820 830 840 850 860 870 pF1KA0 ICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASST 700 710 720 730 740 750 880 890 900 910 920 930 pF1KA0 KAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPP 760 770 780 790 800 810 940 950 960 970 980 990 pF1KA0 GAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLA 820 830 840 850 860 870 1000 1010 1020 1030 1040 1050 pF1KA0 NGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRP 880 890 900 910 920 930 1060 1070 1080 1090 1100 1110 pF1KA0 PPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKH 940 950 960 970 980 990 1120 1130 1140 1150 1160 1170 pF1KA0 GRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPG 1000 1010 1020 1030 1040 1050 1180 1190 1200 1210 1220 1230 pF1KA0 CISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARL 1060 1070 1080 1090 1100 1110 1240 pF1KA0 FKLPPGPEAM :::::::::: NP_001 FKLPPGPEAM 1120 >>NP_001333436 (OMIM: 607955) SAM and SH3 domain-contain (1008 aa) initn: 6747 init1: 6747 opt: 6747 Z-score: 3399.9 bits: 640.9 E(85289): 1.2e-182 Smith-Waterman score: 6747; 99.9% identity (100.0% similar) in 1004 aa overlap (244-1247:5-1008) 220 230 240 250 260 270 pF1KA0 EAQHRQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRK :::::::::::::::::::::::::::::: NP_001 MPKPSREQSDDETEESVKFKRLHKLVNSTRRVRK 10 20 30 280 290 300 310 320 330 pF1KA0 KLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLT 40 50 60 70 80 90 340 350 360 370 380 390 pF1KA0 TSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEM 100 110 120 130 140 150 400 410 420 430 440 450 pF1KA0 KKGLGSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKGLGSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKK 160 170 180 190 200 210 460 470 480 490 500 510 pF1KA0 VKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRS 220 230 240 250 260 270 520 530 540 550 560 570 pF1KA0 SLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTD 280 290 300 310 320 330 580 590 600 610 620 630 pF1KA0 SLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPP 340 350 360 370 380 390 640 650 660 670 680 690 pF1KA0 QPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVEL :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: NP_001 QPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVEL 400 410 420 430 440 450 700 710 720 730 740 750 pF1KA0 LQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEP 460 470 480 490 500 510 760 770 780 790 800 810 pF1KA0 SLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRS 520 530 540 550 560 570 820 830 840 850 860 870 pF1KA0 LPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTT 580 590 600 610 620 630 880 890 900 910 920 930 pF1KA0 ASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYD 640 650 660 670 680 690 940 950 960 970 980 990 pF1KA0 AQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSR 700 710 720 730 740 750 1000 1010 1020 1030 1040 1050 pF1KA0 ERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPP 760 770 780 790 800 810 1060 1070 1080 1090 1100 1110 pF1KA0 STRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPY 820 830 840 850 860 870 1120 1130 1140 1150 1160 1170 pF1KA0 SDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKP 880 890 900 910 920 930 1180 1190 1200 1210 1220 1230 pF1KA0 VSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLS 940 950 960 970 980 990 1240 pF1KA0 AARLFKLPPGPEAM :::::::::::::: NP_001 AARLFKLPPGPEAM 1000 >>NP_001333438 (OMIM: 607955) SAM and SH3 domain-contain (1130 aa) initn: 5707 init1: 5707 opt: 5710 Z-score: 2879.3 bits: 544.8 E(85289): 1.2e-153 Smith-Waterman score: 6185; 85.5% identity (85.6% similar) in 1130 aa overlap (281-1247:1-1130) 260 270 280 290 300 310 pF1KA0 ETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGV :::::::::::::::::::::::::::::: NP_001 MKKPSTEGGEEHVFENSPVLDERSALYSGV 10 20 30 320 330 340 350 360 370 pF1KA0 HKKPLFFDGSPEKPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKKPLFFDGSPEKPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMG 40 50 60 70 80 90 380 390 400 pF1KA0 TFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHG--------------------------- ::::::::::::::::::::::::::::::::: NP_001 TFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHGVSTDGVCFYDNHRRRHHLLVSLEEFQS 100 110 120 130 140 150 pF1KA0 ------------------------------------------------------------ NP_001 VRKQIRLKKTDTNYSCSRAFLCQRPSRKGVTSTTCDLQLLRQKGKGGGSCGFPGRRVRGR 160 170 180 190 200 210 pF1KA0 ------------------------------------------------------------ NP_001 TSVSEFNITYVVERSLYSHLNLTQLVRPASDRTLSKAERQDLRRCLLEEDEEAKRKWAAT 220 230 240 250 260 270 410 420 430 440 pF1KA0 ----------------RTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASR :::::::::::::::::::::::::::::::::::::::::::: NP_001 VDRCTKRVLLRIHQKSRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASR 280 290 300 310 320 330 450 460 470 480 490 500 pF1KA0 ISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGS 340 350 360 370 380 390 510 520 530 540 550 560 pF1KA0 VESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTP 400 410 420 430 440 450 570 580 590 600 610 620 pF1KA0 SPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRR 460 470 480 490 500 510 630 640 650 660 670 680 pF1KA0 RKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELKIRDPEHRAVL :::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::: NP_001 RKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVL 520 530 540 550 560 570 690 700 710 720 730 740 pF1KA0 LTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSA 580 590 600 610 620 630 750 760 770 780 790 800 pF1KA0 KSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGL 640 650 660 670 680 690 810 820 830 840 850 860 pF1KA0 NKNRRSLPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKNRRSLPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPE 700 710 720 730 740 750 870 880 890 900 910 920 pF1KA0 VPQKTTASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPQKTTASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQC 760 770 780 790 800 810 930 940 950 960 970 980 pF1KA0 LPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPV 820 830 840 850 860 870 990 1000 1010 1020 1030 1040 pF1KA0 PAKKSRERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAKKSRERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQ 880 890 900 910 920 930 1050 1060 1070 1080 1090 1100 pF1KA0 APGSPPSTRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APGSPPSTRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGID 940 950 960 970 980 990 1110 1120 1130 1140 1150 1160 pF1KA0 LTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLT 1000 1010 1020 1030 1040 1050 1170 1180 1190 1200 1210 1220 pF1KA0 EICRKPVSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EICRKPVSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERH 1060 1070 1080 1090 1100 1110 1230 1240 pF1KA0 IRKLLSAARLFKLPPGPEAM :::::::::::::::::::: NP_001 IRKLLSAARLFKLPPGPEAM 1120 1130 >>NP_001333437 (OMIM: 607955) SAM and SH3 domain-contain (1171 aa) initn: 5707 init1: 5707 opt: 5710 Z-score: 2879.1 bits: 544.8 E(85289): 1.3e-153 Smith-Waterman score: 6411; 85.9% identity (86.0% similar) in 1167 aa overlap (244-1247:5-1171) 220 230 240 250 260 270 pF1KA0 EAQHRQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRK :::::::::::::::::::::::::::::: NP_001 MPKPSREQSDDETEESVKFKRLHKLVNSTRRVRK 10 20 30 280 290 300 310 320 330 pF1KA0 KLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLT 40 50 60 70 80 90 340 350 360 370 380 390 pF1KA0 TSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEM 100 110 120 130 140 150 400 pF1KA0 KKGLGSLSHG-------------------------------------------------- :::::::::: NP_001 KKGLGSLSHGVSTDGVCFYDNHRRRHHLLVSLEEFQSVRKQIRLKKTDTNYSCSRAFLCQ 160 170 180 190 200 210 pF1KA0 ------------------------------------------------------------ NP_001 RPSRKGVTSTTCDLQLLRQKGKGGGSCGFPGRRVRGRTSVSEFNITYVVERSLYSHLNLT 220 230 240 250 260 270 410 pF1KA0 -----------------------------------------------------RTCSFGG ::::::: NP_001 QLVRPASDRTLSKAERQDLRRCLLEEDEEAKRKWAATVDRCTKRVLLRIHQKSRTCSFGG 280 290 300 310 320 330 420 430 440 450 460 470 pF1KA0 FDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYS 340 350 360 370 380 390 480 490 500 510 520 530 pF1KA0 SSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTD 400 410 420 430 440 450 540 550 560 570 580 590 pF1KA0 SSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPP 460 470 480 490 500 510 600 610 620 630 640 650 pF1KA0 MGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEH 520 530 540 550 560 570 660 670 680 690 700 710 pF1KA0 MPTFLFNGYEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKL ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::: NP_001 MPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKL 580 590 600 610 620 630 720 730 740 750 760 770 pF1KA0 LVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLP 640 650 660 670 680 690 780 790 800 810 820 830 pF1KA0 LMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQT 700 710 720 730 740 750 840 850 860 870 880 890 pF1KA0 VDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDN 760 770 780 790 800 810 900 910 920 930 940 950 pF1KA0 ALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEG 820 830 840 850 860 870 960 970 980 990 1000 1010 pF1KA0 HRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGA 880 890 900 910 920 930 1020 1030 1040 1050 1060 1070 pF1KA0 LPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSL 940 950 960 970 980 990 1080 1090 1100 1110 1120 1130 pF1KA0 QEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRY 1000 1010 1020 1030 1040 1050 1140 1150 1160 1170 1180 1190 pF1KA0 AEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIG 1060 1070 1080 1090 1100 1110 1200 1210 1220 1230 1240 pF1KA0 LPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM 1120 1130 1140 1150 1160 1170 >>XP_016866094 (OMIM: 607955) PREDICTED: SAM and SH3 dom (1286 aa) initn: 5707 init1: 5707 opt: 5710 Z-score: 2878.5 bits: 544.8 E(85289): 1.4e-153 Smith-Waterman score: 7168; 87.2% identity (87.3% similar) in 1279 aa overlap (132-1247:8-1286) 110 120 130 140 150 160 pF1KA0 PTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN :::::::::::::::::::::::::::::: XP_016 MLFQRNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN 10 20 30 170 180 190 200 210 220 pF1KA0 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA 40 50 60 70 80 90 230 240 250 260 270 280 pF1KA0 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM 100 110 120 130 140 150 290 300 310 320 330 340 pF1KA0 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL 160 170 180 190 200 210 350 360 370 380 390 400 pF1KA0 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS 220 230 240 250 260 270 pF1KA0 HG---------------------------------------------------------- :: XP_016 HGVSTDGVCFYDNHRRRHHLLVSLEEFQSVRKQIRLKKTDTNYSCSRAFLCQRPSRKGVT 280 290 300 310 320 330 pF1KA0 ------------------------------------------------------------ XP_016 STTCDLQLLRQKGKGGGSCGFPGRRVRGRTSVSEFNITYVVERSLYSHLNLTQLVRPASD 340 350 360 370 380 390 410 pF1KA0 ---------------------------------------------RTCSFGGFDLTNRSL ::::::::::::::: XP_016 RTLSKAERQDLRRCLLEEDEEAKRKWAATVDRCTKRVLLRIHQKSRTCSFGGFDLTNRSL 400 410 420 430 440 450 420 430 440 450 460 470 pF1KA0 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS 460 470 480 490 500 510 480 490 500 510 520 530 pF1KA0 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES 520 530 540 550 560 570 540 550 560 570 580 590 pF1KA0 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL 580 590 600 610 620 630 600 610 620 630 640 650 pF1KA0 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG 640 650 660 670 680 690 660 670 680 690 700 710 pF1KA0 YEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS ::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::: XP_016 YEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS 700 710 720 730 740 750 720 730 740 750 760 770 pF1KA0 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL 760 770 780 790 800 810 780 790 800 810 820 830 pF1KA0 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH 820 830 840 850 860 870 840 850 860 870 880 890 pF1KA0 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK 880 890 900 910 920 930 900 910 920 930 940 950 pF1KA0 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE 940 950 960 970 980 990 960 970 980 990 1000 1010 pF1KA0 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC 1000 1010 1020 1030 1040 1050 1020 1030 1040 1050 1060 1070 pF1KA0 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG 1060 1070 1080 1090 1100 1110 1080 1090 1100 1110 1120 1130 pF1KA0 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE 1120 1130 1140 1150 1160 1170 1140 1150 1160 1170 1180 1190 pF1KA0 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL 1180 1190 1200 1210 1220 1230 1200 1210 1220 1230 1240 pF1KA0 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM 1240 1250 1260 1270 1280 >>XP_016866093 (OMIM: 607955) PREDICTED: SAM and SH3 dom (1291 aa) initn: 5707 init1: 5707 opt: 5710 Z-score: 2878.5 bits: 544.8 E(85289): 1.4e-153 Smith-Waterman score: 7168; 87.2% identity (87.3% similar) in 1279 aa overlap (132-1247:13-1291) 110 120 130 140 150 160 pF1KA0 PTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN :::::::::::::::::::::::::::::: XP_016 MLTEIKQAIMNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN 10 20 30 40 170 180 190 200 210 220 pF1KA0 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA 50 60 70 80 90 100 230 240 250 260 270 280 pF1KA0 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM 110 120 130 140 150 160 290 300 310 320 330 340 pF1KA0 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL 170 180 190 200 210 220 350 360 370 380 390 400 pF1KA0 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS 230 240 250 260 270 280 pF1KA0 HG---------------------------------------------------------- :: XP_016 HGVSTDGVCFYDNHRRRHHLLVSLEEFQSVRKQIRLKKTDTNYSCSRAFLCQRPSRKGVT 290 300 310 320 330 340 pF1KA0 ------------------------------------------------------------ XP_016 STTCDLQLLRQKGKGGGSCGFPGRRVRGRTSVSEFNITYVVERSLYSHLNLTQLVRPASD 350 360 370 380 390 400 410 pF1KA0 ---------------------------------------------RTCSFGGFDLTNRSL ::::::::::::::: XP_016 RTLSKAERQDLRRCLLEEDEEAKRKWAATVDRCTKRVLLRIHQKSRTCSFGGFDLTNRSL 410 420 430 440 450 460 420 430 440 450 460 470 pF1KA0 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS 470 480 490 500 510 520 480 490 500 510 520 530 pF1KA0 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES 530 540 550 560 570 580 540 550 560 570 580 590 pF1KA0 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL 590 600 610 620 630 640 600 610 620 630 640 650 pF1KA0 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG 650 660 670 680 690 700 660 670 680 690 700 710 pF1KA0 YEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS ::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::: XP_016 YEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS 710 720 730 740 750 760 720 730 740 750 760 770 pF1KA0 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL 770 780 790 800 810 820 780 790 800 810 820 830 pF1KA0 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH 830 840 850 860 870 880 840 850 860 870 880 890 pF1KA0 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK 890 900 910 920 930 940 900 910 920 930 940 950 pF1KA0 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE 950 960 970 980 990 1000 960 970 980 990 1000 1010 pF1KA0 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC 1010 1020 1030 1040 1050 1060 1020 1030 1040 1050 1060 1070 pF1KA0 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG 1070 1080 1090 1100 1110 1120 1080 1090 1100 1110 1120 1130 pF1KA0 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE 1130 1140 1150 1160 1170 1180 1140 1150 1160 1170 1180 1190 pF1KA0 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL 1190 1200 1210 1220 1230 1240 1200 1210 1220 1230 1240 pF1KA0 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM 1250 1260 1270 1280 1290 >>XP_016866091 (OMIM: 607955) PREDICTED: SAM and SH3 dom (1317 aa) initn: 5707 init1: 5707 opt: 5710 Z-score: 2878.4 bits: 544.8 E(85289): 1.4e-153 Smith-Waterman score: 7168; 87.2% identity (87.3% similar) in 1279 aa overlap (132-1247:39-1317) 110 120 130 140 150 160 pF1KA0 PTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN :::::::::::::::::::::::::::::: XP_016 IITTPVSPTCARGWRSCGNGGFPRTWKWNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN 10 20 30 40 50 60 170 180 190 200 210 220 pF1KA0 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA 70 80 90 100 110 120 230 240 250 260 270 280 pF1KA0 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM 130 140 150 160 170 180 290 300 310 320 330 340 pF1KA0 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL 190 200 210 220 230 240 350 360 370 380 390 400 pF1KA0 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS 250 260 270 280 290 300 pF1KA0 HG---------------------------------------------------------- :: XP_016 HGVSTDGVCFYDNHRRRHHLLVSLEEFQSVRKQIRLKKTDTNYSCSRAFLCQRPSRKGVT 310 320 330 340 350 360 pF1KA0 ------------------------------------------------------------ XP_016 STTCDLQLLRQKGKGGGSCGFPGRRVRGRTSVSEFNITYVVERSLYSHLNLTQLVRPASD 370 380 390 400 410 420 410 pF1KA0 ---------------------------------------------RTCSFGGFDLTNRSL ::::::::::::::: XP_016 RTLSKAERQDLRRCLLEEDEEAKRKWAATVDRCTKRVLLRIHQKSRTCSFGGFDLTNRSL 430 440 450 460 470 480 420 430 440 450 460 470 pF1KA0 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS 490 500 510 520 530 540 480 490 500 510 520 530 pF1KA0 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES 550 560 570 580 590 600 540 550 560 570 580 590 pF1KA0 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL 610 620 630 640 650 660 600 610 620 630 640 650 pF1KA0 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG 670 680 690 700 710 720 660 670 680 690 700 710 pF1KA0 YEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS ::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::: XP_016 YEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS 730 740 750 760 770 780 720 730 740 750 760 770 pF1KA0 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL 790 800 810 820 830 840 780 790 800 810 820 830 pF1KA0 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH 850 860 870 880 890 900 840 850 860 870 880 890 pF1KA0 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK 910 920 930 940 950 960 900 910 920 930 940 950 pF1KA0 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE 970 980 990 1000 1010 1020 960 970 980 990 1000 1010 pF1KA0 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC 1030 1040 1050 1060 1070 1080 1020 1030 1040 1050 1060 1070 pF1KA0 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG 1090 1100 1110 1120 1130 1140 1080 1090 1100 1110 1120 1130 pF1KA0 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE 1150 1160 1170 1180 1190 1200 1140 1150 1160 1170 1180 1190 pF1KA0 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL 1210 1220 1230 1240 1250 1260 1200 1210 1220 1230 1240 pF1KA0 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM 1270 1280 1290 1300 1310 >>XP_016866092 (OMIM: 607955) PREDICTED: SAM and SH3 dom (1317 aa) initn: 5707 init1: 5707 opt: 5710 Z-score: 2878.4 bits: 544.8 E(85289): 1.4e-153 Smith-Waterman score: 7168; 87.2% identity (87.3% similar) in 1279 aa overlap (132-1247:39-1317) 110 120 130 140 150 160 pF1KA0 PTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN :::::::::::::::::::::::::::::: XP_016 IITTPVSPTCARGWRSCGNGGFPRTWKWNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN 10 20 30 40 50 60 170 180 190 200 210 220 pF1KA0 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA 70 80 90 100 110 120 230 240 250 260 270 280 pF1KA0 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM 130 140 150 160 170 180 290 300 310 320 330 340 pF1KA0 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL 190 200 210 220 230 240 350 360 370 380 390 400 pF1KA0 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS 250 260 270 280 290 300 pF1KA0 HG---------------------------------------------------------- :: XP_016 HGVSTDGVCFYDNHRRRHHLLVSLEEFQSVRKQIRLKKTDTNYSCSRAFLCQRPSRKGVT 310 320 330 340 350 360 pF1KA0 ------------------------------------------------------------ XP_016 STTCDLQLLRQKGKGGGSCGFPGRRVRGRTSVSEFNITYVVERSLYSHLNLTQLVRPASD 370 380 390 400 410 420 410 pF1KA0 ---------------------------------------------RTCSFGGFDLTNRSL ::::::::::::::: XP_016 RTLSKAERQDLRRCLLEEDEEAKRKWAATVDRCTKRVLLRIHQKSRTCSFGGFDLTNRSL 430 440 450 460 470 480 420 430 440 450 460 470 pF1KA0 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS 490 500 510 520 530 540 480 490 500 510 520 530 pF1KA0 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES 550 560 570 580 590 600 540 550 560 570 580 590 pF1KA0 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL 610 620 630 640 650 660 600 610 620 630 640 650 pF1KA0 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG 670 680 690 700 710 720 660 670 680 690 700 710 pF1KA0 YEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS ::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::: XP_016 YEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS 730 740 750 760 770 780 720 730 740 750 760 770 pF1KA0 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL 790 800 810 820 830 840 780 790 800 810 820 830 pF1KA0 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH 850 860 870 880 890 900 840 850 860 870 880 890 pF1KA0 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK 910 920 930 940 950 960 900 910 920 930 940 950 pF1KA0 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE 970 980 990 1000 1010 1020 960 970 980 990 1000 1010 pF1KA0 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC 1030 1040 1050 1060 1070 1080 1020 1030 1040 1050 1060 1070 pF1KA0 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG 1090 1100 1110 1120 1130 1140 1080 1090 1100 1110 1120 1130 pF1KA0 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE 1150 1160 1170 1180 1190 1200 1140 1150 1160 1170 1180 1190 pF1KA0 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL 1210 1220 1230 1240 1250 1260 1200 1210 1220 1230 1240 pF1KA0 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM 1270 1280 1290 1300 1310 1247 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 01:01:19 2016 done: Fri Nov 4 01:01:22 2016 Total Scan time: 18.000 Total Display time: 0.600 Function used was FASTA [36.3.4 Apr, 2011]