FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0804, 1426 aa 1>>>pF1KA0804 1426 - 1426 aa - 1426 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.7563+/-0.00131; mu= 15.7792+/- 0.078 mean_var=95.3738+/-18.711, 0's: 0 Z-trim(101.5): 47 B-trim: 2 in 1/50 Lambda= 0.131329 statistics sampled from 6536 (6545) to 6536 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.55), E-opt: 0.2 (0.201), width: 16 Scan time: 4.550 The best scores are: opt bits E(32554) CCDS46972.1 VPS8 gene_id:23355|Hs108|chr3 (1426) 9394 1791.7 0 CCDS46971.1 VPS8 gene_id:23355|Hs108|chr3 (1428) 9380 1789.0 0 >>CCDS46972.1 VPS8 gene_id:23355|Hs108|chr3 (1426 aa) initn: 9394 init1: 9394 opt: 9394 Z-score: 9615.2 bits: 1791.7 E(32554): 0 Smith-Waterman score: 9394; 99.9% identity (100.0% similar) in 1426 aa overlap (1-1426:1-1426) 10 20 30 40 50 60 pF1KA0 MENEPDHENVEQSLCAKTSEEELNKSFNLEASLSKFSYIDMDKELEFKNDLIDDKEFDIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 MENEPDHENVEQSLCAKTSEEELNKSFNLEASLSKFSYIDMDKELEFKNDLIDDKEFDIP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 QVDTPPTLESILNETDDEDESFVLEDPTLLNIDTIDSHSYDTSSVASSDSGDRTNLKRKK ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::: CCDS46 QVDTPPTLESILNETDDEDESFILEDPTLLNIDTIDSHSYDTSSVASSDSGDRTNLKRKK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 KLPDSFSLHGSVMRHSLLKGISAQIVSAADKVDAGLPTAIAVSSLIAVGTSHGLALIFDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 KLPDSFSLHGSVMRHSLLKGISAQIVSAADKVDAGLPTAIAVSSLIAVGTSHGLALIFDQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NQALRLCLGSTSVGGQYGAISALSINNDCSRLLCGFAKGQITMWDLASGKLLRSITDAHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 NQALRLCLGSTSVGGQYGAISALSINNDCSRLLCGFAKGQITMWDLASGKLLRSITDAHP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 PGTAILHIKFTDDPTLAICNDSGGSVFELTFKRVMGVRTCESRCLFSGSKGEVCCIEPLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 PGTAILHIKFTDDPTLAICNDSGGSVFELTFKRVMGVRTCESRCLFSGSKGEVCCIEPLH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 SKPELKDHPITQFSLLAMASLTKILVIGLKPSLKVWMTFPYGRMDPSSVPLLAWHFVAVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 SKPELKDHPITQFSLLAMASLTKILVIGLKPSLKVWMTFPYGRMDPSSVPLLAWHFVAVQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 NYVNPMLAFCRGDVVHFLLVKRDESGAIHVTKQKHLHLYYDLINFTWINSRTVVLLDSVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 NYVNPMLAFCRGDVVHFLLVKRDESGAIHVTKQKHLHLYYDLINFTWINSRTVVLLDSVE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 KLHVIDRQTQEELETVEISEVQLVYNSSHFKSLATGGNVSQALALVGEKACYQSISSYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 KLHVIDRQTQEELETVEISEVQLVYNSSHFKSLATGGNVSQALALVGEKACYQSISSYGG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 QIFYLGTKSVYVMMLRSWRERVDHLLKQDCLTEALALAWSFHEGKAKAVVGLSGDASKRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 QIFYLGTKSVYVMMLRSWRERVDHLLKQDCLTEALALAWSFHEGKAKAVVGLSGDASKRK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 AIVADRMVEILFHYADRALKKCPDQGKIQVMEQHFQDMVPVIVDYCLLLQRKDLLFSQMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 AIVADRMVEILFHYADRALKKCPDQGKIQVMEQHFQDMVPVIVDYCLLLQRKDLLFSQMY 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 DKLSENSVAKGVFLECLEPYILSDKLVGITPQVMKDLIVHFQDKKLMENVEALIVHMDIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 DKLSENSVAKGVFLECLEPYILSDKLVGITPQVMKDLIVHFQDKKLMENVEALIVHMDIT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 SLDIQQVVLMCWENRLYDAMIYVYNRGMNEFISPMEKLFRVIAPPLNAGKTLTDEQVVMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 SLDIQQVVLMCWENRLYDAMIYVYNRGMNEFISPMEKLFRVIAPPLNAGKTLTDEQVVMG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 NKLLVYISCCLAGRAYPLGDIPEDLVPLVKNQVFEFLIRLHSAEASPEEEIYPYIRTLLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 NKLLVYISCCLAGRAYPLGDIPEDLVPLVKNQVFEFLIRLHSAEASPEEEIYPYIRTLLH 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 FDTREFLNVLALTFEDFKNDKQAVEYQQRIVDILLKVMVENSDFTPSQVGCLFTFLARQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 FDTREFLNVLALTFEDFKNDKQAVEYQQRIVDILLKVMVENSDFTPSQVGCLFTFLARQL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 AKPDNTLFVNRTLFDQVLEFLCSPDDDSRHSERQQVLLELLQAGGIVQFEESRLIRMAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 AKPDNTLFVNRTLFDQVLEFLCSPDDDSRHSERQQVLLELLQAGGIVQFEESRLIRMAEK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 AEFYQICEFMYEREHQYDKIIDCYLRDPLREEEVFNYIHNILSIPGHSAEEKQSVWQKAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 AEFYQICEFMYEREHQYDKIIDCYLRDPLREEEVFNYIHNILSIPGHSAEEKQSVWQKAM 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 DHIEELVSLKPCKAAELVATHFSGHIETVIKKLQNQVLLFKFLRSLLDPREGIHVNQELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 DHIEELVSLKPCKAAELVATHFSGHIETVIKKLQNQVLLFKFLRSLLDPREGIHVNQELL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 QISPCITEQFIELLCQFNPTQVIETLQVLECYRLEETIQITQKYQLHEVTAYLLEKKGDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 QISPCITEQFIELLCQFNPTQVIETLQVLECYRLEETIQITQKYQLHEVTAYLLEKKGDI 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 HGAFLIMLERLQSKLQEVTHQGENTKEDPSLKDVEDTMVETIALCQRNSHNLNQQQREAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 HGAFLIMLERLQSKLQEVTHQGENTKEDPSLKDVEDTMVETIALCQRNSHNLNQQQREAL 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 WFPLLEAMMAPQKLSSSAIPHLYSEALKSLTMQVLNSMAAFIALPSILQRILQDPVYGKG ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::: CCDS46 WFPLLEAMMAPQKLSSSAIPHLHSEALKSLTMQVLNSMAAFIALPSILQRILQDPVYGKG 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA0 KLGEIQGLILGMLDTFNYEQTLLETTTSLLNQDLHWSLCNLRASVTRGLNPKQDYCSICL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 KLGEIQGLILGMLDTFNYEQTLLETTTSLLNQDLHWSLCNLRASVTRGLNPKQDYCSICL 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA0 QQYKRRQEMADEIIVFSCGHLYHSFCLQNKECTVEFEGQTRWTCYKCSSSNKVGKLSENS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 QQYKRRQEMADEIIVFSCGHLYHSFCLQNKECTVEFEGQTRWTCYKCSSSNKVGKLSENS 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA0 SEIKKGRITPSQVKMSPSYHQSKGDPTAKKGTSEPVLDPQQIQAFDQLCRLYRGSSRLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 SEIKKGRITPSQVKMSPSYHQSKGDPTAKKGTSEPVLDPQQIQAFDQLCRLYRGSSRLAL 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 pF1KA0 LTELSQNRSSESYRPFSGSQSAPAFNSIFQNENFQLQLIPPPVTED :::::::::::::::::::::::::::::::::::::::::::::: CCDS46 LTELSQNRSSESYRPFSGSQSAPAFNSIFQNENFQLQLIPPPVTED 1390 1400 1410 1420 >>CCDS46971.1 VPS8 gene_id:23355|Hs108|chr3 (1428 aa) initn: 8270 init1: 8270 opt: 9380 Z-score: 9600.9 bits: 1789.0 E(32554): 0 Smith-Waterman score: 9380; 99.7% identity (99.9% similar) in 1428 aa overlap (1-1426:1-1428) 10 20 30 40 50 60 pF1KA0 MENEPDHENVEQSLCAKTSEEELNKSFNLEASLSKFSYIDMDKELEFKNDLIDDKEFDIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 MENEPDHENVEQSLCAKTSEEELNKSFNLEASLSKFSYIDMDKELEFKNDLIDDKEFDIP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 QVDTPPTLESILNETDDEDESFVLEDPTLLNIDTIDSHSYDTSSVASSDSGDRTNLKRKK ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::: CCDS46 QVDTPPTLESILNETDDEDESFILEDPTLLNIDTIDSHSYDTSSVASSDSGDRTNLKRKK 70 80 90 100 110 120 130 140 150 160 170 pF1KA0 KLPDSFSLHGSVMRHSLLKGISAQIVSAADKVDAGLPTAIAVSSLIAVGTSHGLALIF-- :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 KLPDSFSLHGSVMRHSLLKGISAQIVSAADKVDAGLPTAIAVSSLIAVGTSHGLALIFGK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA0 DQNQALRLCLGSTSVGGQYGAISALSINNDCSRLLCGFAKGQITMWDLASGKLLRSITDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 DQNQALRLCLGSTSVGGQYGAISALSINNDCSRLLCGFAKGQITMWDLASGKLLRSITDA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KA0 HPPGTAILHIKFTDDPTLAICNDSGGSVFELTFKRVMGVRTCESRCLFSGSKGEVCCIEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 HPPGTAILHIKFTDDPTLAICNDSGGSVFELTFKRVMGVRTCESRCLFSGSKGEVCCIEP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA0 LHSKPELKDHPITQFSLLAMASLTKILVIGLKPSLKVWMTFPYGRMDPSSVPLLAWHFVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 LHSKPELKDHPITQFSLLAMASLTKILVIGLKPSLKVWMTFPYGRMDPSSVPLLAWHFVA 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA0 VQNYVNPMLAFCRGDVVHFLLVKRDESGAIHVTKQKHLHLYYDLINFTWINSRTVVLLDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 VQNYVNPMLAFCRGDVVHFLLVKRDESGAIHVTKQKHLHLYYDLINFTWINSRTVVLLDS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA0 VEKLHVIDRQTQEELETVEISEVQLVYNSSHFKSLATGGNVSQALALVGEKACYQSISSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 VEKLHVIDRQTQEELETVEISEVQLVYNSSHFKSLATGGNVSQALALVGEKACYQSISSY 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA0 GGQIFYLGTKSVYVMMLRSWRERVDHLLKQDCLTEALALAWSFHEGKAKAVVGLSGDASK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 GGQIFYLGTKSVYVMMLRSWRERVDHLLKQDCLTEALALAWSFHEGKAKAVVGLSGDASK 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA0 RKAIVADRMVEILFHYADRALKKCPDQGKIQVMEQHFQDMVPVIVDYCLLLQRKDLLFSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 RKAIVADRMVEILFHYADRALKKCPDQGKIQVMEQHFQDMVPVIVDYCLLLQRKDLLFSQ 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA0 MYDKLSENSVAKGVFLECLEPYILSDKLVGITPQVMKDLIVHFQDKKLMENVEALIVHMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 MYDKLSENSVAKGVFLECLEPYILSDKLVGITPQVMKDLIVHFQDKKLMENVEALIVHMD 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA0 ITSLDIQQVVLMCWENRLYDAMIYVYNRGMNEFISPMEKLFRVIAPPLNAGKTLTDEQVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 ITSLDIQQVVLMCWENRLYDAMIYVYNRGMNEFISPMEKLFRVIAPPLNAGKTLTDEQVV 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA0 MGNKLLVYISCCLAGRAYPLGDIPEDLVPLVKNQVFEFLIRLHSAEASPEEEIYPYIRTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 MGNKLLVYISCCLAGRAYPLGDIPEDLVPLVKNQVFEFLIRLHSAEASPEEEIYPYIRTL 730 740 750 760 770 780 780 790 800 810 820 830 pF1KA0 LHFDTREFLNVLALTFEDFKNDKQAVEYQQRIVDILLKVMVENSDFTPSQVGCLFTFLAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 LHFDTREFLNVLALTFEDFKNDKQAVEYQQRIVDILLKVMVENSDFTPSQVGCLFTFLAR 790 800 810 820 830 840 840 850 860 870 880 890 pF1KA0 QLAKPDNTLFVNRTLFDQVLEFLCSPDDDSRHSERQQVLLELLQAGGIVQFEESRLIRMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 QLAKPDNTLFVNRTLFDQVLEFLCSPDDDSRHSERQQVLLELLQAGGIVQFEESRLIRMA 850 860 870 880 890 900 900 910 920 930 940 950 pF1KA0 EKAEFYQICEFMYEREHQYDKIIDCYLRDPLREEEVFNYIHNILSIPGHSAEEKQSVWQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 EKAEFYQICEFMYEREHQYDKIIDCYLRDPLREEEVFNYIHNILSIPGHSAEEKQSVWQK 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KA0 AMDHIEELVSLKPCKAAELVATHFSGHIETVIKKLQNQVLLFKFLRSLLDPREGIHVNQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 AMDHIEELVSLKPCKAAELVATHFSGHIETVIKKLQNQVLLFKFLRSLLDPREGIHVNQE 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA0 LLQISPCITEQFIELLCQFNPTQVIETLQVLECYRLEETIQITQKYQLHEVTAYLLEKKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 LLQISPCITEQFIELLCQFNPTQVIETLQVLECYRLEETIQITQKYQLHEVTAYLLEKKG 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KA0 DIHGAFLIMLERLQSKLQEVTHQGENTKEDPSLKDVEDTMVETIALCQRNSHNLNQQQRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 DIHGAFLIMLERLQSKLQEVTHQGENTKEDPSLKDVEDTMVETIALCQRNSHNLNQQQRE 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KA0 ALWFPLLEAMMAPQKLSSSAIPHLYSEALKSLTMQVLNSMAAFIALPSILQRILQDPVYG ::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::: CCDS46 ALWFPLLEAMMAPQKLSSSAIPHLHSEALKSLTMQVLNSMAAFIALPSILQRILQDPVYG 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KA0 KGKLGEIQGLILGMLDTFNYEQTLLETTTSLLNQDLHWSLCNLRASVTRGLNPKQDYCSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 KGKLGEIQGLILGMLDTFNYEQTLLETTTSLLNQDLHWSLCNLRASVTRGLNPKQDYCSI 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KA0 CLQQYKRRQEMADEIIVFSCGHLYHSFCLQNKECTVEFEGQTRWTCYKCSSSNKVGKLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 CLQQYKRRQEMADEIIVFSCGHLYHSFCLQNKECTVEFEGQTRWTCYKCSSSNKVGKLSE 1270 1280 1290 1300 1310 1320 1320 1330 1340 1350 1360 1370 pF1KA0 NSSEIKKGRITPSQVKMSPSYHQSKGDPTAKKGTSEPVLDPQQIQAFDQLCRLYRGSSRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 NSSEIKKGRITPSQVKMSPSYHQSKGDPTAKKGTSEPVLDPQQIQAFDQLCRLYRGSSRL 1330 1340 1350 1360 1370 1380 1380 1390 1400 1410 1420 pF1KA0 ALLTELSQNRSSESYRPFSGSQSAPAFNSIFQNENFQLQLIPPPVTED :::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 ALLTELSQNRSSESYRPFSGSQSAPAFNSIFQNENFQLQLIPPPVTED 1390 1400 1410 1420 1426 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 19:44:58 2016 done: Wed Nov 2 19:44:59 2016 Total Scan time: 4.550 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]