FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0810, 812 aa 1>>>pF1KA0810 812 - 812 aa - 812 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.7867+/-0.000429; mu= 13.9986+/- 0.026 mean_var=125.2374+/-25.395, 0's: 0 Z-trim(114.3): 33 B-trim: 0 in 0/54 Lambda= 0.114606 statistics sampled from 24000 (24026) to 24000 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.637), E-opt: 0.2 (0.282), width: 16 Scan time: 11.160 The best scores are: opt bits E(85289) NP_001124437 (OMIM: 607723) SUN domain-containing ( 785) 3785 638.0 4.9e-182 NP_079430 (OMIM: 607723) SUN domain-containing pro ( 702) 3548 598.7 2.8e-170 NP_001165415 (OMIM: 607723) SUN domain-containing ( 682) 3539 597.2 7.7e-170 NP_001165417 (OMIM: 607723) SUN domain-containing ( 257) 1456 252.5 1.7e-66 NP_001165416 (OMIM: 607723) SUN domain-containing ( 278) 1456 252.6 1.8e-66 XP_011528406 (OMIM: 613569) PREDICTED: SUN domain- ( 671) 1036 183.4 2.9e-45 XP_011528407 (OMIM: 613569) PREDICTED: SUN domain- ( 706) 1036 183.4 3e-45 NP_056189 (OMIM: 613569) SUN domain-containing pro ( 717) 1036 183.4 3e-45 NP_001186509 (OMIM: 613569) SUN domain-containing ( 717) 1036 183.4 3e-45 NP_001186508 (OMIM: 613569) SUN domain-containing ( 738) 1036 183.4 3.1e-45 XP_016884237 (OMIM: 613569) PREDICTED: SUN domain- ( 683) 843 151.5 1.2e-35 XP_011526877 (OMIM: 613942) PREDICTED: SUN domain- ( 289) 516 97.1 1.1e-19 XP_011526876 (OMIM: 613942) PREDICTED: SUN domain- ( 354) 516 97.2 1.3e-19 NP_542406 (OMIM: 613942) SUN domain-containing pro ( 379) 516 97.2 1.4e-19 XP_011526875 (OMIM: 613942) PREDICTED: SUN domain- ( 402) 516 97.2 1.5e-19 XP_005260577 (OMIM: 603038) PREDICTED: sperm-assoc ( 344) 490 92.9 2.6e-18 XP_011527311 (OMIM: 603038) PREDICTED: sperm-assoc ( 393) 490 92.9 2.9e-18 NP_003107 (OMIM: 603038) sperm-associated antigen ( 437) 490 93.0 3.1e-18 NP_001304860 (OMIM: 603038) sperm-associated antig ( 360) 487 92.4 3.8e-18 >>NP_001124437 (OMIM: 607723) SUN domain-containing prot (785 aa) initn: 5205 init1: 3763 opt: 3785 Z-score: 3389.1 bits: 638.0 E(85289): 4.9e-182 Smith-Waterman score: 5155; 96.4% identity (96.7% similar) in 812 aa overlap (1-812:1-785) 10 20 30 40 50 60 pF1KA0 MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 TACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: NP_001 TACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 TVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGVAAATAH :::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::: NP_001 TVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGAAAATAH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKCDDCKGKRHLDAHPGRAGTLW :::::::::::::::::::::::::::::::::::::::: NP_001 NGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKC-------------------- 190 200 210 220 250 260 270 280 290 300 pF1KA0 HIWACAGYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTL ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -------YFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTL 230 240 250 260 270 310 320 330 340 350 360 pF1KA0 ISWLNVFLLTRCLRNICKFLVLLIPLFLLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISWLNVFLLTRCLRNICKFLVLLIPLFLLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVD 280 290 300 310 320 330 370 380 390 400 410 420 pF1KA0 DPQDVFKPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPQDVFKPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKL 340 350 360 370 380 390 430 440 450 460 470 480 pF1KA0 QARVDQMEGGAAGPSASVRDAVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QARVDQMEGGAAGPSASVRDAVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQ 400 410 420 430 440 450 490 500 510 520 530 540 pF1KA0 KELEQTKQKTISAVGEQLLPTVEHLQLELDQLKSELSSWRHVKTGCETVDAVQERVDVQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KELEQTKQKTISAVGEQLLPTVEHLQLELDQLKSELSSWRHVKTGCETVDAVQERVDVQV 460 470 480 490 500 510 550 560 570 580 590 600 pF1KA0 REMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLP 520 530 540 550 560 570 610 620 630 640 650 660 pF1KA0 TSEAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSEAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSET 580 590 600 610 620 630 670 680 690 700 710 720 pF1KA0 YETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTL 640 650 660 670 680 690 730 740 750 760 770 780 pF1KA0 EHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDT 700 710 720 730 740 750 790 800 810 pF1KA0 AFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK :::::::::::::::::::::::::::::::: NP_001 AFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK 760 770 780 >>NP_079430 (OMIM: 607723) SUN domain-containing protein (702 aa) initn: 4629 init1: 3548 opt: 3548 Z-score: 3178.0 bits: 598.7 E(85289): 2.8e-170 Smith-Waterman score: 4518; 91.9% identity (92.1% similar) in 762 aa overlap (51-812:1-702) 30 40 50 60 70 80 pF1KA0 YTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSA :::::::::::::::::::::::::::::: NP_079 MSRRSLRLATTACTLGDGEAVGADSGTSSA 10 20 30 90 100 110 120 130 140 pF1KA0 VSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSYGGTVSLQDAVTRRPPVLDESWI :::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::: NP_079 VSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHGGTVSLQDAVTRRPPVLDESWI 40 50 60 70 80 90 150 160 170 180 190 200 pF1KA0 REQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGVAAATAHNGFSCSNCSMLSERKDVLTA :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: NP_079 REQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTA 100 110 120 130 140 150 210 220 230 240 250 260 pF1KA0 HPAAPGPVSRVYSRDRNQKCDDCKGKRHLDAHPGRAGTLWHIWACAGYFLLQILRRIGAV ::::::::::::::::::: : NP_079 HPAAPGPVSRVYSRDRNQK--------------------W-------------------- 160 170 270 280 290 300 310 320 pF1KA0 GQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISWLNVFLLTRCLRNICKFL :::::::::::::::::::::::::::::::::::::::: NP_079 --------------------KAASGVFWWLGIGWYQFVTLISWLNVFLLTRCLRNICKFL 180 190 200 210 330 340 350 360 370 380 pF1KA0 VLLIPLFLLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVDDPQDVFKPTTSRLKQPLQGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 VLLIPLFLLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVDDPQDVFKPTTSRLKQPLQGD 220 230 240 250 260 270 390 400 410 420 430 440 pF1KA0 SEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARVDQMEGGAAGPSASVRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 SEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARVDQMEGGAAGPSASVRD 280 290 300 310 320 330 450 460 470 480 490 500 pF1KA0 AVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQKELEQTKQKTISAVGEQLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 AVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQKELEQTKQKTISAVGEQLLP 340 350 360 370 380 390 510 520 530 540 550 560 pF1KA0 TVEHLQLELDQLKSELSSWRHVKTGCETVDAVQERVDVQVREMVKLLFSEDQQGGSLEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 TVEHLQLELDQLKSELSSWRHVKTGCETVDAVQERVDVQVREMVKLLFSEDQQGGSLEQL 400 410 420 430 440 450 570 580 590 600 610 620 pF1KA0 LQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLPTSEAVVSAVSEAGASGITEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 LQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLPTSEAVVSAVSEAGASGITEA 460 470 480 490 500 510 630 640 650 660 670 680 pF1KA0 QARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALMSLFGIPLWYFSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 QARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALMSLFGIPLWYFSQ 520 530 540 550 560 570 690 700 710 720 730 740 pF1KA0 SPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 SPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDF 580 590 600 610 620 630 750 760 770 780 790 800 pF1KA0 AVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 AVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYTC 640 650 660 670 680 690 810 pF1KA0 LYRFRVHGEPVK :::::::::::: NP_079 LYRFRVHGEPVK 700 >>NP_001165415 (OMIM: 607723) SUN domain-containing prot (682 aa) initn: 4177 init1: 3203 opt: 3539 Z-score: 3170.2 bits: 597.2 E(85289): 7.7e-170 Smith-Waterman score: 4250; 83.9% identity (84.0% similar) in 812 aa overlap (1-812:1-682) 10 20 30 40 50 60 pF1KA0 MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 TACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: NP_001 TACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 TVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGVAAATAH ::::::::::::::::::::::::::::::: NP_001 TVSLQDAVTRRPPVLDESWIREQTTVDHFWG----------------------------- 130 140 150 190 200 210 220 230 240 pF1KA0 NGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKCDDCKGKRHLDAHPGRAGTLW NP_001 ------------------------------------------------------------ 250 260 270 280 290 300 pF1KA0 HIWACAGYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTL :::::::::::::::::::: NP_001 ----------------------------------------KAASGVFWWLGIGWYQFVTL 160 170 310 320 330 340 350 360 pF1KA0 ISWLNVFLLTRCLRNICKFLVLLIPLFLLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVD :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: NP_001 ISWLNVFLLTRCLRNICKFLVLLIPLFLLL-GLSLRGQGNFFSFLPVLNWASMHRTQRVD 180 190 200 210 220 230 370 380 390 400 410 420 pF1KA0 DPQDVFKPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPQDVFKPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKL 240 250 260 270 280 290 430 440 450 460 470 480 pF1KA0 QARVDQMEGGAAGPSASVRDAVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QARVDQMEGGAAGPSASVRDAVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQ 300 310 320 330 340 350 490 500 510 520 530 540 pF1KA0 KELEQTKQKTISAVGEQLLPTVEHLQLELDQLKSELSSWRHVKTGCETVDAVQERVDVQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KELEQTKQKTISAVGEQLLPTVEHLQLELDQLKSELSSWRHVKTGCETVDAVQERVDVQV 360 370 380 390 400 410 550 560 570 580 590 600 pF1KA0 REMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLP 420 430 440 450 460 470 610 620 630 640 650 660 pF1KA0 TSEAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSEAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSET 480 490 500 510 520 530 670 680 690 700 710 720 pF1KA0 YETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTL 540 550 560 570 580 590 730 740 750 760 770 780 pF1KA0 EHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDT 600 610 620 630 640 650 790 800 810 pF1KA0 AFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK :::::::::::::::::::::::::::::::: NP_001 AFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK 660 670 680 >>NP_001165417 (OMIM: 607723) SUN domain-containing prot (257 aa) initn: 1456 init1: 1456 opt: 1456 Z-score: 1314.8 bits: 252.5 E(85289): 1.7e-66 Smith-Waterman score: 1456; 99.1% identity (100.0% similar) in 220 aa overlap (1-220:1-220) 10 20 30 40 50 60 pF1KA0 MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 TACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: NP_001 TACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 TVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGVAAATAH :::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::: NP_001 TVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGAAAATAH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKCDDCKGKRHLDAHPGRAGTLW :::::::::::::::::::::::::::::::::::::::: NP_001 NGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKCKSQSFKTQKKVCFPNLIFPF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HIWACAGYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTL NP_001 CKSQCLHYLSWRLKIIP 250 >>NP_001165416 (OMIM: 607723) SUN domain-containing prot (278 aa) initn: 1456 init1: 1456 opt: 1456 Z-score: 1314.3 bits: 252.6 E(85289): 1.8e-66 Smith-Waterman score: 1456; 99.1% identity (100.0% similar) in 220 aa overlap (1-220:22-241) 10 20 30 pF1KA0 MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETE ::::::::::::::::::::::::::::::::::::::: NP_001 MGRISPGSPGLPRTVWFEVVNMDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 HKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNK 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 SAFSINHVSRQVTSSGVSYGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLK ::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::: NP_001 SAFSINHVSRQVTSSGVSHGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLK 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA0 GGNKAAIQGNGDVGVAAATAHNGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQK ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGNKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQK 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA0 CDDCKGKRHLDAHPGRAGTLWHIWACAGYFLLQILRRIGAVGQAVSRTAWSALWLAVVAP : NP_001 CKSQSFKTQKKVCFPNLIFPFCKSQCLHYLSWRLKIIP 250 260 270 >>XP_011528406 (OMIM: 613569) PREDICTED: SUN domain-cont (671 aa) initn: 1150 init1: 757 opt: 1036 Z-score: 933.6 bits: 183.4 E(85289): 2.9e-45 Smith-Waterman score: 1220; 35.7% identity (63.2% similar) in 712 aa overlap (141-810:4-669) 120 130 140 150 160 170 pF1KA0 VTSSGVSYGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNG : : . . : ::::. ..:.... XP_011 MSRRSQRLTRYSQG-DDDGSSSSGGSSV----- 10 20 180 190 200 210 220 pF1KA0 DVGVAAATAHNGFSCSNCSMLSERKDVLTAHPAAP--GPVSRVYSRDRNQKCDDCKGKRH :.. . :. : :..... . :: :: : ... ... : XP_011 -----AGSQSTLFKDSPLRTLKRKSSNMKRLSPAPQLGPSSDAHTSYYSESL------VH 30 40 50 60 70 230 240 250 260 270 280 pF1KA0 LDAHPGRAGTL-WHIWACAGYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVF . : :.. : : :: .. . . .:::: : : ::.....::. .. XP_011 ESWFPPRSSLEELHGDANWGYSDVDQQSSSSRLRSAVSR-AGSLLWMVATSPGRLFRLLY 80 90 100 110 120 130 290 300 310 320 330 340 pF1KA0 WWLGIGWYQFVTLISWLNVFLLTRCLRNICKFLVLLIPLFLLLAGLSLRGQGNFF----- :: : ::...: : :.::.::: . .. :: .:.:: :::. :. : :. XP_011 WWAGTTWYRLTTAASLLDVFVLTRRFSSLKTFLWFLLPL-LLLTCLTY-GAWYFYPYGLQ 140 150 160 170 180 190 350 360 370 380 390 400 pF1KA0 SFLPVL-NWASMHRTQRVDDPQDVFKPTTSRLKQP-LQGDSEAFPWHWMSGVEQQVASLS .: :.: .: . . ..: :. . .: ..: .:..... :: :.. : XP_011 TFHPALVSWWAAKDSRRPDEGWE------ARDSSPHFQAEQRV-----MSRVHSLERRLE 200 210 220 230 240 410 420 430 440 pF1KA0 GQCHHHGENLRELTTLLQKLQARVDQM-EGGAAGPS-----------ASVRDAVGQPPRE . . . : .. . :..:. : .::..: : .: :.:. . . XP_011 ALAAEFSSNWQKEAMRLERLELRQGAPGQGGGGGLSHEDTLALLEGLVSRREAALKEDFR 250 260 270 280 290 300 450 460 470 480 490 500 pF1KA0 TDFMAFHQEH--EVRMSHL---EDILGKLREKSEAIQKELEQTKQKTISAVGEQLLPT-V . : ::. .: : ::.. :. . :. . ...: :.. : . :.. . : XP_011 RETAARIQEELSALRAEHQQDSEDLFKKIVRASQESEARIQQLKSEWQSMTQESFQESSV 310 320 330 340 350 360 510 520 530 540 550 pF1KA0 EHLQLELDQL---KSELSSWRHVKTGC--------ETVDAVQERVDVQVREMVKLLFSED ..:. ::: ..::.. ... . ..::.. :. : .. ... XP_011 KELRRLEDQLAGLQQELAALALKQSSVAEEVGLLPQQIQAVRDDVESQFPAWISQFLA-- 370 380 390 400 410 420 560 570 580 590 600 pF1KA0 QQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLPTSEAVVS---A . ::. :::: ..:..::.:. .:: ::. . . ::..: . XP_011 RGGGGRVGLLQRE--------EMQAQLRELESKILT----HVAEMQGKSAREAAASLSLT 430 440 450 460 610 620 630 640 650 660 pF1KA0 VSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALM ... :. :.:: :.. ::..::. ::.:. :..:.::::::.:..::::::::::::::. XP_011 LQKEGVIGVTEEQVHHIVKQALQRYSEDRIGLADYALESGGASVISTRCSETYETKTALL 470 480 490 500 510 520 670 680 690 700 710 720 pF1KA0 SLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLS ::::::::: ::::::..:::..:::::::.: ::. ::::: :.:.: ::::.::.:: XP_011 SLFGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALS 530 540 550 560 570 580 730 740 750 760 770 780 pF1KA0 PTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDTAFQIVELR :...:::::::::..:.... :.:: :::.:::::::: .: :. .. : ...:.:::: XP_011 PNSTISSAPKDFAIFGFDEDLQQEGTLLGKFTYDQDGEPIQTFH-FQAPTMATYQVVELR 590 600 610 620 630 640 790 800 810 pF1KA0 IFSNWGHPEYTCLYRFRVHGEPVK :..:::::::::.::::::::: XP_011 ILTNWGHPEYTCIYRFRVHGEPAH 650 660 670 >>XP_011528407 (OMIM: 613569) PREDICTED: SUN domain-cont (706 aa) initn: 1150 init1: 757 opt: 1036 Z-score: 933.3 bits: 183.4 E(85289): 3e-45 Smith-Waterman score: 1220; 35.7% identity (63.2% similar) in 712 aa overlap (141-810:39-704) 120 130 140 150 160 170 pF1KA0 VTSSGVSYGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNG : : . . : ::::. ..:.... XP_011 QRLRGVPVWAAGAFRFSSGEESTSHLIMSRRSQRLTRYSQG-DDDGSSSSGGSSV----- 10 20 30 40 50 60 180 190 200 210 220 pF1KA0 DVGVAAATAHNGFSCSNCSMLSERKDVLTAHPAAP--GPVSRVYSRDRNQKCDDCKGKRH :.. . :. : :..... . :: :: : ... ... : XP_011 -----AGSQSTLFKDSPLRTLKRKSSNMKRLSPAPQLGPSSDAHTSYYSESL------VH 70 80 90 100 110 230 240 250 260 270 280 pF1KA0 LDAHPGRAGTL-WHIWACAGYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVF . : :.. : : :: .. . . .:::: : : ::.....::. .. XP_011 ESWFPPRSSLEELHGDANWGYSDVDQQSSSSRLRSAVSR-AGSLLWMVATSPGRLFRLLY 120 130 140 150 160 170 290 300 310 320 330 340 pF1KA0 WWLGIGWYQFVTLISWLNVFLLTRCLRNICKFLVLLIPLFLLLAGLSLRGQGNFF----- :: : ::...: : :.::.::: . .. :: .:.:: :::. :. : :. XP_011 WWAGTTWYRLTTAASLLDVFVLTRRFSSLKTFLWFLLPL-LLLTCLTY-GAWYFYPYGLQ 180 190 200 210 220 350 360 370 380 390 400 pF1KA0 SFLPVL-NWASMHRTQRVDDPQDVFKPTTSRLKQP-LQGDSEAFPWHWMSGVEQQVASLS .: :.: .: . . ..: :. . .: ..: .:..... :: :.. : XP_011 TFHPALVSWWAAKDSRRPDEGWE------ARDSSPHFQAEQRV-----MSRVHSLERRLE 230 240 250 260 270 410 420 430 440 pF1KA0 GQCHHHGENLRELTTLLQKLQARVDQM-EGGAAGPS-----------ASVRDAVGQPPRE . . . : .. . :..:. : .::..: : .: :.:. . . XP_011 ALAAEFSSNWQKEAMRLERLELRQGAPGQGGGGGLSHEDTLALLEGLVSRREAALKEDFR 280 290 300 310 320 330 450 460 470 480 490 500 pF1KA0 TDFMAFHQEH--EVRMSHL---EDILGKLREKSEAIQKELEQTKQKTISAVGEQLLPT-V . : ::. .: : ::.. :. . :. . ...: :.. : . :.. . : XP_011 RETAARIQEELSALRAEHQQDSEDLFKKIVRASQESEARIQQLKSEWQSMTQESFQESSV 340 350 360 370 380 390 510 520 530 540 550 pF1KA0 EHLQLELDQL---KSELSSWRHVKTGC--------ETVDAVQERVDVQVREMVKLLFSED ..:. ::: ..::.. ... . ..::.. :. : .. ... XP_011 KELRRLEDQLAGLQQELAALALKQSSVAEEVGLLPQQIQAVRDDVESQFPAWISQFLA-- 400 410 420 430 440 450 560 570 580 590 600 pF1KA0 QQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLPTSEAVVS---A . ::. :::: ..:..::.:. .:: ::. . . ::..: . XP_011 RGGGGRVGLLQRE--------EMQAQLRELESKILT----HVAEMQGKSAREAAASLSLT 460 470 480 490 500 610 620 630 640 650 660 pF1KA0 VSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALM ... :. :.:: :.. ::..::. ::.:. :..:.::::::.:..::::::::::::::. XP_011 LQKEGVIGVTEEQVHHIVKQALQRYSEDRIGLADYALESGGASVISTRCSETYETKTALL 510 520 530 540 550 560 670 680 690 700 710 720 pF1KA0 SLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLS ::::::::: ::::::..:::..:::::::.: ::. ::::: :.:.: ::::.::.:: XP_011 SLFGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALS 570 580 590 600 610 620 730 740 750 760 770 780 pF1KA0 PTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDTAFQIVELR :...:::::::::..:.... :.:: :::.:::::::: .: :. .. : ...:.:::: XP_011 PNSTISSAPKDFAIFGFDEDLQQEGTLLGKFTYDQDGEPIQTFH-FQAPTMATYQVVELR 630 640 650 660 670 680 790 800 810 pF1KA0 IFSNWGHPEYTCLYRFRVHGEPVK :..:::::::::.::::::::: XP_011 ILTNWGHPEYTCIYRFRVHGEPAH 690 700 >>NP_056189 (OMIM: 613569) SUN domain-containing protein (717 aa) initn: 1150 init1: 757 opt: 1036 Z-score: 933.2 bits: 183.4 E(85289): 3e-45 Smith-Waterman score: 1215; 34.6% identity (60.4% similar) in 803 aa overlap (51-810:1-715) 30 40 50 60 70 80 pF1KA0 YTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSA ::::: :: : . :: .. ....:.: : NP_056 MSRRSQRL--TRYSQGDDDGSSSSGGSSVA 10 20 90 100 110 120 130 pF1KA0 VS----LKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSYGGTVSLQDAVTRRPPVLD : .:. :: : :.:.: . .: . :. :. .. . : .. NP_056 GSQSTLFKDSPLRTLK-RKSSNMKRLSP---APQLGPSSDAHTSYYS--------ESLVH 30 40 50 60 70 140 150 160 170 180 190 pF1KA0 ESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGVAAATAHNGFSCSNCSMLSERKD :::. ....... :: . :. :. : . .: : : : :: NP_056 ESWFPPRSSLEEL-----HGDANWGE--------DLRVRRRRGTGGSESSRASGLVGRKA 80 90 100 110 120 200 210 220 230 240 250 pF1KA0 VLTAHPAAPGPVSRVYSRDRNQKCDDCKGKRHLDAHPGRAGTLWHIWACAGYFLLQILRR . .. : :: . :: : .: . . . :: NP_056 TEDFLGSSSG-----YSSE-----DDYVGYSDVDQQSSSSR----------------LR- 130 140 150 260 270 280 290 300 310 pF1KA0 IGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISWLNVFLLTRCLRNI .:::: : : ::.....::. ..:: : ::...: : :.::.::: . .. NP_056 -----SAVSR-AGSLLWMVATSPGRLFRLLYWWAGTTWYRLTTAASLLDVFVLTRRFSSL 160 170 180 190 200 210 320 330 340 350 360 370 pF1KA0 CKFLVLLIPLFLLLAGLSLRGQGNFF-----SFLPVL-NWASMHRTQRVDDPQDVFKPTT :: .:.:: :::. :. : :. .: :.: .: . . ..: :. . NP_056 KTFLWFLLPL-LLLTCLTY-GAWYFYPYGLQTFHPALVSWWAAKDSRRPDEGWE------ 220 230 240 250 260 380 390 400 410 420 pF1KA0 SRLKQP-LQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARVDQM-E .: ..: .:..... :: :.. : . . . : .. . :..:. : . NP_056 ARDSSPHFQAEQRV-----MSRVHSLERRLEALAAEFSSNWQKEAMRLERLELRQGAPGQ 270 280 290 300 310 430 440 450 460 470 pF1KA0 GGAAGPS-----------ASVRDAVGQPPRETDFMAFHQEH--EVRMSHL---EDILGKL ::..: : .: :.:. . . . : ::. .: : ::.. :. NP_056 GGGGGLSHEDTLALLEGLVSRREAALKEDFRRETAARIQEELSALRAEHQQDSEDLFKKI 320 330 340 350 360 370 480 490 500 510 520 pF1KA0 REKSEAIQKELEQTKQKTISAVGEQLLPT-VEHLQLELDQL---KSELSSWRHVKTGC-- . :. . ...: :.. : . :.. . :..:. ::: ..::.. ... NP_056 VRASQESEARIQQLKSEWQSMTQESFQESSVKELRRLEDQLAGLQQELAALALKQSSVAE 380 390 400 410 420 430 530 540 550 560 570 580 pF1KA0 ------ETVDAVQERVDVQVREMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRD . ..::.. :. : .. .... ::. :::: ..:..::. NP_056 EVGLLPQQIQAVRDDVESQFPAWISQFLARG--GGGRVGLLQRE--------EMQAQLRE 440 450 460 470 480 590 600 610 620 630 pF1KA0 LQLQILRNVTHHVSVTKQLPTSEAVVS---AVSEAGASGITEAQARAIVNSALKLYSQDK :. .:: ::. . . ::..: .... :. :.:: :.. ::..::. ::.:. NP_056 LESKILT----HVAEMQGKSAREAAASLSLTLQKEGVIGVTEEQVHHIVKQALQRYSEDR 490 500 510 520 530 540 640 650 660 670 680 690 pF1KA0 TGMVDFALESGGGSILSTRCSETYETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWA :..:.::::::.:..::::::::::::::.::::::::: ::::::..:::..:::::: NP_056 IGLADYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPGNCWA 550 560 570 580 590 600 700 710 720 730 740 750 pF1KA0 FKGSQGYLVVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLG :.: ::. ::::: :.:.: ::::.::.:::...:::::::::..:.... :.:: ::: NP_056 FQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLG 610 620 630 640 650 660 760 770 780 790 800 810 pF1KA0 QFTYDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK .:::::::: .: :. .. : ...:.:::::..:::::::::.::::::::: NP_056 KFTYDQDGEPIQTFH-FQAPTMATYQVVELRILTNWGHPEYTCIYRFRVHGEPAH 670 680 690 700 710 >>NP_001186509 (OMIM: 613569) SUN domain-containing prot (717 aa) initn: 1150 init1: 757 opt: 1036 Z-score: 933.2 bits: 183.4 E(85289): 3e-45 Smith-Waterman score: 1215; 34.6% identity (60.4% similar) in 803 aa overlap (51-810:1-715) 30 40 50 60 70 80 pF1KA0 YTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSA ::::: :: : . :: .. ....:.: : NP_001 MSRRSQRL--TRYSQGDDDGSSSSGGSSVA 10 20 90 100 110 120 130 pF1KA0 VS----LKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSYGGTVSLQDAVTRRPPVLD : .:. :: : :.:.: . .: . :. :. .. . : .. NP_001 GSQSTLFKDSPLRTLK-RKSSNMKRLSP---APQLGPSSDAHTSYYS--------ESLVH 30 40 50 60 70 140 150 160 170 180 190 pF1KA0 ESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGVAAATAHNGFSCSNCSMLSERKD :::. ....... :: . :. :. : . .: : : : :: NP_001 ESWFPPRSSLEEL-----HGDANWGE--------DLRVRRRRGTGGSESSRASGLVGRKA 80 90 100 110 120 200 210 220 230 240 250 pF1KA0 VLTAHPAAPGPVSRVYSRDRNQKCDDCKGKRHLDAHPGRAGTLWHIWACAGYFLLQILRR . .. : :: . :: : .: . . . :: NP_001 TEDFLGSSSG-----YSSE-----DDYVGYSDVDQQSSSSR----------------LR- 130 140 150 260 270 280 290 300 310 pF1KA0 IGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISWLNVFLLTRCLRNI .:::: : : ::.....::. ..:: : ::...: : :.::.::: . .. NP_001 -----SAVSR-AGSLLWMVATSPGRLFRLLYWWAGTTWYRLTTAASLLDVFVLTRRFSSL 160 170 180 190 200 210 320 330 340 350 360 370 pF1KA0 CKFLVLLIPLFLLLAGLSLRGQGNFF-----SFLPVL-NWASMHRTQRVDDPQDVFKPTT :: .:.:: :::. :. : :. .: :.: .: . . ..: :. . NP_001 KTFLWFLLPL-LLLTCLTY-GAWYFYPYGLQTFHPALVSWWAAKDSRRPDEGWE------ 220 230 240 250 260 380 390 400 410 420 pF1KA0 SRLKQP-LQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARVDQM-E .: ..: .:..... :: :.. : . . . : .. . :..:. : . NP_001 ARDSSPHFQAEQRV-----MSRVHSLERRLEALAAEFSSNWQKEAMRLERLELRQGAPGQ 270 280 290 300 310 430 440 450 460 470 pF1KA0 GGAAGPS-----------ASVRDAVGQPPRETDFMAFHQEH--EVRMSHL---EDILGKL ::..: : .: :.:. . . . : ::. .: : ::.. :. NP_001 GGGGGLSHEDTLALLEGLVSRREAALKEDFRRETAARIQEELSALRAEHQQDSEDLFKKI 320 330 340 350 360 370 480 490 500 510 520 pF1KA0 REKSEAIQKELEQTKQKTISAVGEQLLPT-VEHLQLELDQL---KSELSSWRHVKTGC-- . :. . ...: :.. : . :.. . :..:. ::: ..::.. ... NP_001 VRASQESEARIQQLKSEWQSMTQESFQESSVKELRRLEDQLAGLQQELAALALKQSSVAE 380 390 400 410 420 430 530 540 550 560 570 580 pF1KA0 ------ETVDAVQERVDVQVREMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRD . ..::.. :. : .. .... ::. :::: ..:..::. NP_001 EVGLLPQQIQAVRDDVESQFPAWISQFLARG--GGGRVGLLQRE--------EMQAQLRE 440 450 460 470 480 590 600 610 620 630 pF1KA0 LQLQILRNVTHHVSVTKQLPTSEAVVS---AVSEAGASGITEAQARAIVNSALKLYSQDK :. .:: ::. . . ::..: .... :. :.:: :.. ::..::. ::.:. NP_001 LESKILT----HVAEMQGKSAREAAASLSLTLQKEGVIGVTEEQVHHIVKQALQRYSEDR 490 500 510 520 530 540 640 650 660 670 680 690 pF1KA0 TGMVDFALESGGGSILSTRCSETYETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWA :..:.::::::.:..::::::::::::::.::::::::: ::::::..:::..:::::: NP_001 IGLADYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPGNCWA 550 560 570 580 590 600 700 710 720 730 740 750 pF1KA0 FKGSQGYLVVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLG :.: ::. ::::: :.:.: ::::.::.:::...:::::::::..:.... :.:: ::: NP_001 FQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLG 610 620 630 640 650 660 760 770 780 790 800 810 pF1KA0 QFTYDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK .:::::::: .: :. .. : ...:.:::::..:::::::::.::::::::: NP_001 KFTYDQDGEPIQTFH-FQAPTMATYQVVELRILTNWGHPEYTCIYRFRVHGEPAH 670 680 690 700 710 >>NP_001186508 (OMIM: 613569) SUN domain-containing prot (738 aa) initn: 1150 init1: 757 opt: 1036 Z-score: 933.1 bits: 183.4 E(85289): 3.1e-45 Smith-Waterman score: 1249; 34.7% identity (61.4% similar) in 803 aa overlap (51-810:1-736) 30 40 50 60 70 80 pF1KA0 YTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSA ::::: :: : . :: .. ....:.: : NP_001 MSRRSQRL--TRYSQGDDDGSSSSGGSSVA 10 20 90 100 110 120 130 pF1KA0 VS----LKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSYGGTVSLQDAVTRRPPVLD : .:. :: : :.:.: . .: . :. :. .. . : .. NP_001 GSQSTLFKDSPLRTLK-RKSSNMKRLSP---APQLGPSSDAHTSYYS--------ESLVH 30 40 50 60 70 140 150 160 170 180 190 pF1KA0 ESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGVAAATAHNGFSCSNCSMLSERKD :::. ....... :: . :. :. : . .: : : : :: NP_001 ESWFPPRSSLEEL-----HGDANWGE--------DLRVRRRRGTGGSESSRASGLVGRK- 80 90 100 110 120 200 210 220 230 240 250 pF1KA0 VLTAHPAAPGPVSRVYSRDRNQKCDDCKGKRHLDAHPGRAGTLWHIWACAGYFLLQILRR : : : :.: . .. .:.. ...: . ::: .. NP_001 ---ATEDFLGSSSGYSSEDDYVEDSEGRGSKVTETEPVSSFP-------AGYSDVDQQSS 130 140 150 160 170 260 270 280 290 300 310 pF1KA0 IGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISWLNVFLLTRCLRNI . . .:::: : : ::.....::. ..:: : ::...: : :.::.::: . .. NP_001 SSRLRSAVSR-AGSLLWMVATSPGRLFRLLYWWAGTTWYRLTTAASLLDVFVLTRRFSSL 180 190 200 210 220 230 320 330 340 350 360 370 pF1KA0 CKFLVLLIPLFLLLAGLSLRGQGNFF-----SFLPVL-NWASMHRTQRVDDPQDVFKPTT :: .:.:: :::. :. : :. .: :.: .: . . ..: :. . NP_001 KTFLWFLLPL-LLLTCLTY-GAWYFYPYGLQTFHPALVSWWAAKDSRRPDEGWE------ 240 250 260 270 280 380 390 400 410 420 pF1KA0 SRLKQP-LQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARVDQM-E .: ..: .:..... :: :.. : . . . : .. . :..:. : . NP_001 ARDSSPHFQAEQRV-----MSRVHSLERRLEALAAEFSSNWQKEAMRLERLELRQGAPGQ 290 300 310 320 330 430 440 450 460 470 pF1KA0 GGAAGPS-----------ASVRDAVGQPPRETDFMAFHQEH--EVRMSHL---EDILGKL ::..: : .: :.:. . . . : ::. .: : ::.. :. NP_001 GGGGGLSHEDTLALLEGLVSRREAALKEDFRRETAARIQEELSALRAEHQQDSEDLFKKI 340 350 360 370 380 390 480 490 500 510 520 pF1KA0 REKSEAIQKELEQTKQKTISAVGEQLLPT-VEHLQLELDQL---KSELSSWRHVKTGC-- . :. . ...: :.. : . :.. . :..:. ::: ..::.. ... NP_001 VRASQESEARIQQLKSEWQSMTQESFQESSVKELRRLEDQLAGLQQELAALALKQSSVAE 400 410 420 430 440 450 530 540 550 560 570 580 pF1KA0 ------ETVDAVQERVDVQVREMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRD . ..::.. :. : .. .... ::. :::: ..:..::. NP_001 EVGLLPQQIQAVRDDVESQFPAWISQFLARG--GGGRVGLLQRE--------EMQAQLRE 460 470 480 490 500 590 600 610 620 630 pF1KA0 LQLQILRNVTHHVSVTKQLPTSEAVVS---AVSEAGASGITEAQARAIVNSALKLYSQDK :. .:: ::. . . ::..: .... :. :.:: :.. ::..::. ::.:. NP_001 LESKILT----HVAEMQGKSAREAAASLSLTLQKEGVIGVTEEQVHHIVKQALQRYSEDR 510 520 530 540 550 560 640 650 660 670 680 690 pF1KA0 TGMVDFALESGGGSILSTRCSETYETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWA :..:.::::::.:..::::::::::::::.::::::::: ::::::..:::..:::::: NP_001 IGLADYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPGNCWA 570 580 590 600 610 620 700 710 720 730 740 750 pF1KA0 FKGSQGYLVVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLG :.: ::. ::::: :.:.: ::::.::.:::...:::::::::..:.... :.:: ::: NP_001 FQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLG 630 640 650 660 670 680 760 770 780 790 800 810 pF1KA0 QFTYDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK .:::::::: .: :. .. : ...:.:::::..:::::::::.::::::::: NP_001 KFTYDQDGEPIQTFH-FQAPTMATYQVVELRILTNWGHPEYTCIYRFRVHGEPAH 690 700 710 720 730 812 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 01:02:06 2016 done: Fri Nov 4 01:02:07 2016 Total Scan time: 11.160 Total Display time: 0.200 Function used was FASTA [36.3.4 Apr, 2011]