FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0815, 1229 aa 1>>>pF1KA0815 1229 - 1229 aa - 1229 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.3724+/-0.000569; mu= 14.6733+/- 0.035 mean_var=318.9808+/-64.457, 0's: 0 Z-trim(117.0): 644 B-trim: 71 in 1/52 Lambda= 0.071811 statistics sampled from 27940 (28713) to 27940 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.658), E-opt: 0.2 (0.337), width: 16 Scan time: 13.340 The best scores are: opt bits E(85289) XP_006710469 (OMIM: 604266) PREDICTED: multiple ep (1436) 8125 857.8 0 NP_001400 (OMIM: 604266) multiple epidermal growth (1541) 7722 816.1 0 XP_011539188 (OMIM: 604266) PREDICTED: multiple ep (1560) 7722 816.1 0 XP_011539187 (OMIM: 604266) PREDICTED: multiple ep (1603) 7722 816.2 0 XP_011539190 (OMIM: 604266) PREDICTED: multiple ep (1364) 7707 814.5 0 XP_011539189 (OMIM: 604266) PREDICTED: multiple ep (1395) 7401 782.8 0 XP_016856022 (OMIM: 604266) PREDICTED: multiple ep (1559) 5473 583.1 4.7e-165 XP_016878162 (OMIM: 612454) PREDICTED: multiple ep (1021) 2348 259.1 1.1e-67 NP_115821 (OMIM: 612454) multiple epidermal growth (1044) 2348 259.1 1.1e-67 XP_016878161 (OMIM: 612454) PREDICTED: multiple ep (1044) 2348 259.1 1.1e-67 XP_016878160 (OMIM: 612454) PREDICTED: multiple ep (1092) 2348 259.2 1.1e-67 NP_001243474 (OMIM: 612453,614399) multiple epider (1140) 2331 257.4 3.9e-67 XP_011541996 (OMIM: 612453,614399) PREDICTED: mult (1140) 2331 257.4 3.9e-67 NP_115822 (OMIM: 612453,614399) multiple epidermal (1140) 2331 257.4 3.9e-67 XP_016865476 (OMIM: 612453,614399) PREDICTED: mult (1195) 2331 257.5 4e-67 XP_016856726 (OMIM: 610278) PREDICTED: platelet en ( 973) 2154 239.0 1.2e-61 XP_016856728 (OMIM: 610278) PREDICTED: platelet en ( 973) 2154 239.0 1.2e-61 XP_016856727 (OMIM: 610278) PREDICTED: platelet en ( 973) 2154 239.0 1.2e-61 XP_011507813 (OMIM: 610278) PREDICTED: platelet en (1002) 2154 239.0 1.2e-61 XP_011507812 (OMIM: 610278) PREDICTED: platelet en (1037) 2154 239.0 1.2e-61 XP_016856725 (OMIM: 610278) PREDICTED: platelet en (1037) 2154 239.0 1.2e-61 NP_001073940 (OMIM: 610278) platelet endothelial a (1037) 2154 239.0 1.2e-61 XP_005245198 (OMIM: 610278) PREDICTED: platelet en (1037) 2154 239.0 1.2e-61 XP_016856723 (OMIM: 610278) PREDICTED: platelet en (1125) 2154 239.1 1.3e-61 XP_016878159 (OMIM: 612454) PREDICTED: multiple ep (1097) 1965 219.5 9.8e-56 XP_016856729 (OMIM: 610278) PREDICTED: platelet en ( 909) 1954 218.2 2e-55 XP_016856730 (OMIM: 610278) PREDICTED: platelet en ( 909) 1954 218.2 2e-55 XP_016856731 (OMIM: 610278) PREDICTED: platelet en ( 909) 1954 218.2 2e-55 XP_016856724 (OMIM: 610278) PREDICTED: platelet en (1081) 1848 207.3 4.3e-52 XP_011507814 (OMIM: 610278) PREDICTED: platelet en ( 868) 1808 203.1 6.8e-51 XP_016878163 (OMIM: 612454) PREDICTED: multiple ep ( 854) 1342 154.8 2.3e-36 XP_016878164 (OMIM: 612454) PREDICTED: multiple ep ( 854) 1342 154.8 2.3e-36 NP_001295048 (OMIM: 612453,614399) multiple epider ( 567) 1288 148.9 9e-35 NP_001295050 (OMIM: 612453,614399) multiple epider ( 567) 1288 148.9 9e-35 XP_005259981 (OMIM: 125310,130720,600276,615293) P (2269) 1118 132.2 3.8e-29 XP_011517019 (OMIM: 109730,190198,616028) PREDICTE (2314) 1077 128.0 7.2e-28 NP_060087 (OMIM: 109730,190198,616028) neurogenic (2555) 1077 128.1 7.6e-28 XP_016882866 (OMIM: 608529) PREDICTED: fibrillin-3 (1948) 1066 126.7 1.4e-27 NP_000129 (OMIM: 102370,129600,134797,154700,18490 (2871) 1062 126.6 2.4e-27 XP_016865477 (OMIM: 612453,614399) PREDICTED: mult ( 760) 986 117.8 2.8e-25 XP_016882864 (OMIM: 608529) PREDICTED: fibrillin-3 (2768) 993 119.4 3.3e-25 NP_000426 (OMIM: 125310,130720,600276,615293) neur (2321) 975 117.4 1.1e-24 XP_016882865 (OMIM: 608529) PREDICTED: fibrillin-3 (2766) 948 114.7 8.4e-24 XP_016882863 (OMIM: 608529) PREDICTED: fibrillin-3 (2777) 948 114.7 8.4e-24 XP_016882862 (OMIM: 608529) PREDICTED: fibrillin-3 (2789) 948 114.7 8.4e-24 XP_016882861 (OMIM: 608529) PREDICTED: fibrillin-3 (2809) 948 114.8 8.4e-24 NP_001308360 (OMIM: 608529) fibrillin-3 precursor (2809) 948 114.8 8.4e-24 NP_115823 (OMIM: 608529) fibrillin-3 precursor [Ho (2809) 948 114.8 8.4e-24 XP_016882868 (OMIM: 608529) PREDICTED: fibrillin-3 (2851) 948 114.8 8.5e-24 XP_016864717 (OMIM: 121050,612570,616118) PREDICTE (2861) 932 113.1 2.7e-23 >>XP_006710469 (OMIM: 604266) PREDICTED: multiple epider (1436 aa) initn: 9616 init1: 7674 opt: 8125 Z-score: 4569.5 bits: 857.8 E(85289): 0 Smith-Waterman score: 8738; 89.4% identity (89.6% similar) in 1261 aa overlap (1-1131:1-1261) 10 20 30 40 50 60 pF1KA0 MGASRDRGLAALWCLGLLGGLARVAGTHYRYLWRGCYPCHLGQAGYPVSAGDQRPDVDEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGASRDRGLAALWCLGLLGGLARVAGTHYRYLWRGCYPCHLGQAGYPVSAGDQRPDVDEC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 RTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 RCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACED 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 CSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 DGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 PFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 FGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 ACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 GEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 CQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAI 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 SGLCLCEAGYVGPRCEQQCPQGHFGPGCEQLCQCQHGAACDHVSGACTCPAGWRGTFCEH :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: XP_006 SGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEH 790 800 810 820 830 840 850 860 870 880 pF1KA0 ACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAE----------------- ::::::::::::::::::::::::::::::::::::::::::: XP_006 ACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACAC 850 860 870 880 890 900 pF1KA0 ------------------------------------------------------------ XP_006 FNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPE 910 920 930 940 950 960 890 900 910 920 930 pF1KA0 ---------KCLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFG .:::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFG 970 980 990 1000 1010 1020 940 950 960 970 pF1KA0 EACAQRCSCPPAAACHHVTGACRCPPGFTGSGCEQGCPPG-------------------- :::::::::::.:::::::::::::::::::::::.:::: XP_006 EACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACH 1030 1040 1050 1060 1070 1080 980 990 1000 1010 pF1KA0 ------------------------RYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDC :::::::::::::::::::::::::::::::::::: XP_006 PATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDC 1090 1100 1110 1120 1130 1140 1020 1030 1040 1050 1060 1070 pF1KA0 NLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTC 1150 1160 1170 1180 1190 1200 1080 1090 1100 1110 1120 1130 pF1KA0 SCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRC 1210 1220 1230 1240 1250 1260 1140 1150 1160 1170 1180 1190 pF1KA0 GPGFYGQACEHRRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPT : XP_006 GPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGS 1270 1280 1290 1300 1310 1320 >-- initn: 1507 init1: 663 opt: 969 Z-score: 562.8 bits: 116.5 E(85289): 1.3e-24 Smith-Waterman score: 969; 67.4% identity (78.3% similar) in 184 aa overlap (1046-1229:1262-1436) 1020 1030 1040 1050 1060 1070 pF1KA0 QGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNG :: : ::. :: . :.::. : :..: XP_006 PGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHG 1240 1250 1260 1270 1280 1290 1080 1090 1100 1110 1120 1130 pF1KA0 GLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFY . : .: : : :. :. :: .: :: .: .:: .:.: ... :.:.:: : : :: XP_006 APCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPG-- 1300 1310 1320 1330 1340 1140 1150 1160 1170 1180 1190 pF1KA0 GQACEHRRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGG ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 -------RSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGG 1350 1360 1370 1380 1390 1400 1200 1210 1220 pF1KA0 PLRLPENPSLAQGSAGTLPASSRPTSRSGGPARH :::::::::::::::::::::::::::::::::: XP_006 PLRLPENPSLAQGSAGTLPASSRPTSRSGGPARH 1410 1420 1430 >>NP_001400 (OMIM: 604266) multiple epidermal growth fac (1541 aa) initn: 9206 init1: 7264 opt: 7722 Z-score: 4343.6 bits: 816.1 E(85289): 0 Smith-Waterman score: 8335; 87.9% identity (88.3% similar) in 1225 aa overlap (38-1131:146-1366) 10 20 30 40 50 60 pF1KA0 GLAALWCLGLLGGLARVAGTHYRYLWRGCYPCHLGQAGYPVSAGDQ-RPDVDECRTHNGG ::: : : . . ::::::::::: NP_001 QQPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCP----PGFQGPRCQYDVDECRTHNGG 120 130 140 150 160 170 70 80 90 100 110 120 pF1KA0 CQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRP 180 190 200 210 220 230 130 140 150 160 170 180 pF1KA0 GFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAA 240 250 260 270 280 290 190 200 210 220 230 240 pF1KA0 GLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSA 300 310 320 330 340 350 250 260 270 280 290 300 pF1KA0 GPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCE 360 370 380 390 400 410 310 320 330 340 350 360 pF1KA0 DVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPL 420 430 440 450 460 470 370 380 390 400 410 420 pF1KA0 PHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGG 480 490 500 510 520 530 430 440 450 460 470 480 pF1KA0 TCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSG 540 550 560 570 580 590 490 500 510 520 530 540 pF1KA0 TNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCS 600 610 620 630 640 650 550 560 570 580 590 600 pF1KA0 EECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVS 660 670 680 690 700 710 610 620 630 640 650 660 pF1KA0 GECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEA 720 730 740 750 760 770 670 680 690 700 710 720 pF1KA0 DCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCS 780 790 800 810 820 830 730 740 750 760 770 780 pF1KA0 CANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLC 840 850 860 870 880 890 790 800 810 820 830 840 pF1KA0 EAGYVGPRCEQQCPQGHFGPGCEQLCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGF :::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::: NP_001 EAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGF 900 910 920 930 940 950 850 860 870 880 pF1KA0 FGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAE----------------------- ::::::::::::::::::::::::::::::::::::: NP_001 FGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASC 960 970 980 990 1000 1010 pF1KA0 ------------------------------------------------------------ NP_001 DPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLA 1020 1030 1040 1050 1060 1070 890 900 910 920 930 940 pF1KA0 ---KCLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQR .:::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQR 1080 1090 1100 1110 1120 1130 950 960 970 pF1KA0 CSCPPAAACHHVTGACRCPPGFTGSGCEQGCPPG-------------------------- :::::.:::::::::::::::::::::::.:::: NP_001 CSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTC 1140 1150 1160 1170 1180 1190 980 990 1000 1010 pF1KA0 ------------------RYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQ :::::::::::::::::::::::::::::::::::::::::: NP_001 SCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQ 1200 1210 1220 1230 1240 1250 1020 1030 1040 1050 1060 1070 pF1KA0 GRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGG 1260 1270 1280 1290 1300 1310 1080 1090 1100 1110 1120 1130 pF1KA0 LCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYG ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYG 1320 1330 1340 1350 1360 1370 1140 1150 1160 1170 1180 1190 pF1KA0 QACEHRRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGGP NP_001 QACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCH 1380 1390 1400 1410 1420 1430 >-- initn: 1507 init1: 663 opt: 969 Z-score: 562.5 bits: 116.5 E(85289): 1.4e-24 Smith-Waterman score: 969; 67.4% identity (78.3% similar) in 184 aa overlap (1046-1229:1367-1541) 1020 1030 1040 1050 1060 1070 pF1KA0 QGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNG :: : ::. :: . :.::. : :..: NP_001 PGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHG 1340 1350 1360 1370 1380 1390 1080 1090 1100 1110 1120 1130 pF1KA0 GLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFY . : .: : : :. :. :: .: :: .: .:: .:.: ... :.:.:: : : :: NP_001 APCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPG-- 1400 1410 1420 1430 1440 1450 1140 1150 1160 1170 1180 1190 pF1KA0 GQACEHRRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGG ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -------RSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGG 1460 1470 1480 1490 1500 1200 1210 1220 pF1KA0 PLRLPENPSLAQGSAGTLPASSRPTSRSGGPARH :::::::::::::::::::::::::::::::::: NP_001 PLRLPENPSLAQGSAGTLPASSRPTSRSGGPARH 1510 1520 1530 1540 >>XP_011539188 (OMIM: 604266) PREDICTED: multiple epider (1560 aa) initn: 7872 init1: 7264 opt: 7722 Z-score: 4343.5 bits: 816.1 E(85289): 0 Smith-Waterman score: 8335; 87.9% identity (88.3% similar) in 1225 aa overlap (38-1131:208-1428) 10 20 30 40 50 60 pF1KA0 GLAALWCLGLLGGLARVAGTHYRYLWRGCYPCHLGQAGYPVSAGDQ-RPDVDECRTHNGG ::: : : . . ::::::::::: XP_011 QQPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCP----PGFQGPRCQYDVDECRTHNGG 180 190 200 210 220 230 70 80 90 100 110 120 pF1KA0 CQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRP 240 250 260 270 280 290 130 140 150 160 170 180 pF1KA0 GFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAA 300 310 320 330 340 350 190 200 210 220 230 240 pF1KA0 GLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSA 360 370 380 390 400 410 250 260 270 280 290 300 pF1KA0 GPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCE 420 430 440 450 460 470 310 320 330 340 350 360 pF1KA0 DVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPL 480 490 500 510 520 530 370 380 390 400 410 420 pF1KA0 PHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGG 540 550 560 570 580 590 430 440 450 460 470 480 pF1KA0 TCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSG 600 610 620 630 640 650 490 500 510 520 530 540 pF1KA0 TNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCS 660 670 680 690 700 710 550 560 570 580 590 600 pF1KA0 EECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVS 720 730 740 750 760 770 610 620 630 640 650 660 pF1KA0 GECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEA 780 790 800 810 820 830 670 680 690 700 710 720 pF1KA0 DCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCS 840 850 860 870 880 890 730 740 750 760 770 780 pF1KA0 CANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLC 900 910 920 930 940 950 790 800 810 820 830 840 pF1KA0 EAGYVGPRCEQQCPQGHFGPGCEQLCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGF :::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::: XP_011 EAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGF 960 970 980 990 1000 1010 850 860 870 880 pF1KA0 FGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAE----------------------- ::::::::::::::::::::::::::::::::::::: XP_011 FGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASC 1020 1030 1040 1050 1060 1070 pF1KA0 ------------------------------------------------------------ XP_011 DPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLA 1080 1090 1100 1110 1120 1130 890 900 910 920 930 940 pF1KA0 ---KCLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQR .:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQR 1140 1150 1160 1170 1180 1190 950 960 970 pF1KA0 CSCPPAAACHHVTGACRCPPGFTGSGCEQGCPPG-------------------------- :::::.:::::::::::::::::::::::.:::: XP_011 CSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTC 1200 1210 1220 1230 1240 1250 980 990 1000 1010 pF1KA0 ------------------RYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQ :::::::::::::::::::::::::::::::::::::::::: XP_011 SCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQ 1260 1270 1280 1290 1300 1310 1020 1030 1040 1050 1060 1070 pF1KA0 GRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGG 1320 1330 1340 1350 1360 1370 1080 1090 1100 1110 1120 1130 pF1KA0 LCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYG ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYG 1380 1390 1400 1410 1420 1430 1140 1150 1160 1170 1180 1190 pF1KA0 QACEHRRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGGP XP_011 QACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERDCRRGQFGPSCT 1440 1450 1460 1470 1480 1490 >-- initn: 846 init1: 622 opt: 789 Z-score: 461.7 bits: 97.9 E(85289): 5.6e-19 Smith-Waterman score: 789; 72.9% identity (82.9% similar) in 140 aa overlap (1090-1229:1430-1560) 1060 1070 1080 1090 1100 1110 pF1KA0 NRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNS :. :. :: :::: .::.:. : :.... XP_011 GRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGA 1400 1410 1420 1430 1440 1450 1120 1130 1140 1150 1160 1170 pF1KA0 TCEPATGTCRCGPGFYGQACEHRRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQ :.: .: : : ::.:. ::. ::::::::::::::::::::::::::::: XP_011 PCDPISGRCLCPAGFHGHFCER---------DCRRGQFGPSCTLHCDCGGGADCDPVSGQ 1460 1470 1480 1490 1500 1510 1180 1190 1200 1210 1220 pF1KA0 CHCVDGYMGPTCREGGPLRLPENPSLAQGSAGTLPASSRPTSRSGGPARH :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CHCVDGYMGPTCREGGPLRLPENPSLAQGSAGTLPASSRPTSRSGGPARH 1520 1530 1540 1550 1560 >>XP_011539187 (OMIM: 604266) PREDICTED: multiple epider (1603 aa) initn: 9206 init1: 7264 opt: 7722 Z-score: 4343.4 bits: 816.2 E(85289): 0 Smith-Waterman score: 8335; 87.9% identity (88.3% similar) in 1225 aa overlap (38-1131:208-1428) 10 20 30 40 50 60 pF1KA0 GLAALWCLGLLGGLARVAGTHYRYLWRGCYPCHLGQAGYPVSAGDQ-RPDVDECRTHNGG ::: : : . . ::::::::::: XP_011 QQPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCP----PGFQGPRCQYDVDECRTHNGG 180 190 200 210 220 230 70 80 90 100 110 120 pF1KA0 CQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRP 240 250 260 270 280 290 130 140 150 160 170 180 pF1KA0 GFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAA 300 310 320 330 340 350 190 200 210 220 230 240 pF1KA0 GLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSA 360 370 380 390 400 410 250 260 270 280 290 300 pF1KA0 GPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCE 420 430 440 450 460 470 310 320 330 340 350 360 pF1KA0 DVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPL 480 490 500 510 520 530 370 380 390 400 410 420 pF1KA0 PHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGG 540 550 560 570 580 590 430 440 450 460 470 480 pF1KA0 TCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSG 600 610 620 630 640 650 490 500 510 520 530 540 pF1KA0 TNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCS 660 670 680 690 700 710 550 560 570 580 590 600 pF1KA0 EECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVS 720 730 740 750 760 770 610 620 630 640 650 660 pF1KA0 GECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEA 780 790 800 810 820 830 670 680 690 700 710 720 pF1KA0 DCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCS 840 850 860 870 880 890 730 740 750 760 770 780 pF1KA0 CANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLC 900 910 920 930 940 950 790 800 810 820 830 840 pF1KA0 EAGYVGPRCEQQCPQGHFGPGCEQLCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGF :::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::: XP_011 EAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGF 960 970 980 990 1000 1010 850 860 870 880 pF1KA0 FGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAE----------------------- ::::::::::::::::::::::::::::::::::::: XP_011 FGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASC 1020 1030 1040 1050 1060 1070 pF1KA0 ------------------------------------------------------------ XP_011 DPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLA 1080 1090 1100 1110 1120 1130 890 900 910 920 930 940 pF1KA0 ---KCLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQR .:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQR 1140 1150 1160 1170 1180 1190 950 960 970 pF1KA0 CSCPPAAACHHVTGACRCPPGFTGSGCEQGCPPG-------------------------- :::::.:::::::::::::::::::::::.:::: XP_011 CSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTC 1200 1210 1220 1230 1240 1250 980 990 1000 1010 pF1KA0 ------------------RYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQ :::::::::::::::::::::::::::::::::::::::::: XP_011 SCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQ 1260 1270 1280 1290 1300 1310 1020 1030 1040 1050 1060 1070 pF1KA0 GRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGG 1320 1330 1340 1350 1360 1370 1080 1090 1100 1110 1120 1130 pF1KA0 LCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYG ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYG 1380 1390 1400 1410 1420 1430 1140 1150 1160 1170 1180 1190 pF1KA0 QACEHRRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGGP XP_011 QACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCH 1440 1450 1460 1470 1480 1490 >-- initn: 1507 init1: 663 opt: 969 Z-score: 562.4 bits: 116.5 E(85289): 1.4e-24 Smith-Waterman score: 969; 67.4% identity (78.3% similar) in 184 aa overlap (1046-1229:1429-1603) 1020 1030 1040 1050 1060 1070 pF1KA0 QGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNG :: : ::. :: . :.::. : :..: XP_011 PGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHG 1400 1410 1420 1430 1440 1450 1080 1090 1100 1110 1120 1130 pF1KA0 GLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFY . : .: : : :. :. :: .: :: .: .:: .:.: ... :.:.:: : : :: XP_011 APCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPG-- 1460 1470 1480 1490 1500 1510 1140 1150 1160 1170 1180 1190 pF1KA0 GQACEHRRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGG ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 -------RSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGG 1520 1530 1540 1550 1560 1200 1210 1220 pF1KA0 PLRLPENPSLAQGSAGTLPASSRPTSRSGGPARH :::::::::::::::::::::::::::::::::: XP_011 PLRLPENPSLAQGSAGTLPASSRPTSRSGGPARH 1570 1580 1590 1600 >>XP_011539190 (OMIM: 604266) PREDICTED: multiple epider (1364 aa) initn: 7264 init1: 7264 opt: 7707 Z-score: 4335.7 bits: 814.5 E(85289): 0 Smith-Waterman score: 7724; 83.0% identity (88.4% similar) in 1174 aa overlap (38-1209:208-1362) 10 20 30 40 50 60 pF1KA0 GLAALWCLGLLGGLARVAGTHYRYLWRGCYPCHLGQAGYPVSAGDQ-RPDVDECRTHNGG ::: : : . . ::::::::::: XP_011 QQPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCP----PGFQGPRCQYDVDECRTHNGG 180 190 200 210 220 230 70 80 90 100 110 120 pF1KA0 CQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRP 240 250 260 270 280 290 130 140 150 160 170 180 pF1KA0 GFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAA 300 310 320 330 340 350 190 200 210 220 230 240 pF1KA0 GLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSA 360 370 380 390 400 410 250 260 270 280 290 300 pF1KA0 GPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCE 420 430 440 450 460 470 310 320 330 340 350 360 pF1KA0 DVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPL 480 490 500 510 520 530 370 380 390 400 410 420 pF1KA0 PHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGG 540 550 560 570 580 590 430 440 450 460 470 480 pF1KA0 TCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSG 600 610 620 630 640 650 490 500 510 520 530 540 pF1KA0 TNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCS 660 670 680 690 700 710 550 560 570 580 590 600 pF1KA0 EECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVS 720 730 740 750 760 770 610 620 630 640 650 660 pF1KA0 GECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEA 780 790 800 810 820 830 670 680 690 700 710 720 pF1KA0 DCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCS 840 850 860 870 880 890 730 740 750 760 770 780 pF1KA0 CANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLC 900 910 920 930 940 950 790 800 810 820 830 840 pF1KA0 EAGYVGPRCEQQCPQGHFGPGCEQLCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGF :::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::: XP_011 EAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGF 960 970 980 990 1000 1010 850 860 870 880 890 900 pF1KA0 FGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAEKCLPRDVRAGCRHSGGCLNGGLC ::::::::::::::::::::::::::::::::::::: : . .: .. .:.::. : XP_011 FGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASC 1020 1030 1040 1050 1060 1070 910 920 930 940 950 960 pF1KA0 DPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPAAACHHVTGACRCPPGFTGSG :: :.: : :: : .: . : : .:. : . : : ...: :.: : :: :..: . XP_011 DPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLA 1080 1090 1100 1110 1120 1130 970 980 990 1000 1010 1020 pF1KA0 CEQGCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHV ::. : : ::.. :::::: :: :: : ::.:. : :. : .: :: :.. XP_011 CEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQR 1140 1150 1160 1170 1180 1190 1030 1040 1050 1060 1070 1080 pF1KA0 CGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRN-GGLCHASNGSC :.: :::: :::.: :::: .: ::..:: . :: : . :.: . . :: ..:.: XP_011 CSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTC 1200 1210 1220 1230 1240 1250 1090 1100 1110 1120 1130 1140 pF1KA0 SCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHRRSG ::. :. : :. ::::::: .:. :.: :...:. :::.::: :: : XP_011 SCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFL---------G 1260 1270 1280 1290 1300 1150 1160 1170 1180 1190 1200 pF1KA0 ATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGGPLRLPENPSL . ::: : .:.:::.:: : :: :: ::::.: : : : : :. :.:. :.: XP_011 TDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCE-----RVPR-PGL 1310 1320 1330 1340 1350 1210 1220 pF1KA0 AQGSAGTLPASSRPTSRSGGPARH : :: XP_011 ALGSLR 1360 >>XP_011539189 (OMIM: 604266) PREDICTED: multiple epider (1395 aa) initn: 8884 init1: 6942 opt: 7401 Z-score: 4164.3 bits: 782.8 E(85289): 0 Smith-Waterman score: 8324; 86.1% identity (86.4% similar) in 1261 aa overlap (1-1131:1-1220) 10 20 30 40 50 60 pF1KA0 MGASRDRGLAALWCLGLLGGLARVAGTHYRYLWRGCYPCHLGQAGYPVSAGDQRPDVDEC ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGASRDRGLAALWCLGLLGGLARVAGTHYRYLWRGCYPCHLGQAGYPVSAGDQRP----- 10 20 30 40 50 70 80 90 100 110 120 pF1KA0 RTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRH :::::::::::::::::::::::: XP_011 ------------------------------------AINSCALGNGGCQHHCVQLTITRH 60 70 130 140 150 160 170 180 pF1KA0 RCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACED 80 90 100 110 120 130 190 200 210 220 230 240 pF1KA0 VDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHG 140 150 160 170 180 190 250 260 270 280 290 300 pF1KA0 CSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSA 200 210 220 230 240 250 310 320 330 340 350 360 pF1KA0 DGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGEL 260 270 280 290 300 310 370 380 390 400 410 420 pF1KA0 PFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCD 320 330 340 350 360 370 430 440 450 460 470 480 pF1KA0 DCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRC 380 390 400 410 420 430 490 500 510 520 530 540 pF1KA0 PPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWA 440 450 460 470 480 490 550 560 570 580 590 600 pF1KA0 FGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGV 500 510 520 530 540 550 610 620 630 640 650 660 pF1KA0 ACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRT 560 570 580 590 600 610 670 680 690 700 710 720 pF1KA0 GEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPS 620 630 640 650 660 670 730 740 750 760 770 780 pF1KA0 CQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAI 680 690 700 710 720 730 790 800 810 820 830 840 pF1KA0 SGLCLCEAGYVGPRCEQQCPQGHFGPGCEQLCQCQHGAACDHVSGACTCPAGWRGTFCEH :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: XP_011 SGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEH 740 750 760 770 780 790 850 860 870 880 pF1KA0 ACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAE----------------- ::::::::::::::::::::::::::::::::::::::::::: XP_011 ACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACAC 800 810 820 830 840 850 pF1KA0 ------------------------------------------------------------ XP_011 FNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPE 860 870 880 890 900 910 890 900 910 920 930 pF1KA0 ---------KCLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFG .:::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFG 920 930 940 950 960 970 940 950 960 970 pF1KA0 EACAQRCSCPPAAACHHVTGACRCPPGFTGSGCEQGCPPG-------------------- :::::::::::.:::::::::::::::::::::::.:::: XP_011 EACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACH 980 990 1000 1010 1020 1030 980 990 1000 1010 pF1KA0 ------------------------RYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDC :::::::::::::::::::::::::::::::::::: XP_011 PATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDC 1040 1050 1060 1070 1080 1090 1020 1030 1040 1050 1060 1070 pF1KA0 NLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTC 1100 1110 1120 1130 1140 1150 1080 1090 1100 1110 1120 1130 pF1KA0 SCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRC 1160 1170 1180 1190 1200 1210 1140 1150 1160 1170 1180 1190 pF1KA0 GPGFYGQACEHRRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPT : XP_011 GPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGS 1220 1230 1240 1250 1260 1270 >-- initn: 1507 init1: 663 opt: 969 Z-score: 562.9 bits: 116.5 E(85289): 1.3e-24 Smith-Waterman score: 969; 67.4% identity (78.3% similar) in 184 aa overlap (1046-1229:1221-1395) 1020 1030 1040 1050 1060 1070 pF1KA0 QGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNG :: : ::. :: . :.::. : :..: XP_011 PGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHG 1200 1210 1220 1230 1240 1250 1080 1090 1100 1110 1120 1130 pF1KA0 GLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFY . : .: : : :. :. :: .: :: .: .:: .:.: ... :.:.:: : : :: XP_011 APCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPG-- 1260 1270 1280 1290 1300 1140 1150 1160 1170 1180 1190 pF1KA0 GQACEHRRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGG ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 -------RSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGG 1310 1320 1330 1340 1350 1360 1200 1210 1220 pF1KA0 PLRLPENPSLAQGSAGTLPASSRPTSRSGGPARH :::::::::::::::::::::::::::::::::: XP_011 PLRLPENPSLAQGSAGTLPASSRPTSRSGGPARH 1370 1380 1390 >>XP_016856022 (OMIM: 604266) PREDICTED: multiple epider (1559 aa) initn: 6201 init1: 4259 opt: 5473 Z-score: 3084.3 bits: 583.1 E(85289): 4.7e-165 Smith-Waterman score: 7875; 84.2% identity (84.7% similar) in 1225 aa overlap (38-1131:208-1384) 10 20 30 40 50 60 pF1KA0 GLAALWCLGLLGGLARVAGTHYRYLWRGCYPCHLGQAGYPVSAGDQ-RPDVDECRTHNGG ::: : : . . ::::::::::: XP_016 QQPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCP----PGFQGPRCQYDVDECRTHNGG 180 190 200 210 220 230 70 80 90 100 110 120 pF1KA0 CQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRP 240 250 260 270 280 290 130 140 150 160 170 180 pF1KA0 GFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAA 300 310 320 330 340 350 190 200 210 220 230 240 pF1KA0 GLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSA 360 370 380 390 400 410 250 260 270 280 290 300 pF1KA0 GPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCE 420 430 440 450 460 470 310 320 330 340 350 360 pF1KA0 DVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPL 480 490 500 510 520 530 370 380 390 400 410 420 pF1KA0 PHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGG ::::::::::::::::::::::::::::::::::::::.: XP_016 PHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFAC-------------------- 540 550 560 570 430 440 450 460 470 480 pF1KA0 TCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSG :::::::::::::::::::::::::::::::::::: XP_016 ------------------------PPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSG 580 590 600 490 500 510 520 530 540 pF1KA0 TNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCS 610 620 630 640 650 660 550 560 570 580 590 600 pF1KA0 EECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVS 670 680 690 700 710 720 610 620 630 640 650 660 pF1KA0 GECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEA 730 740 750 760 770 780 670 680 690 700 710 720 pF1KA0 DCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCS 790 800 810 820 830 840 730 740 750 760 770 780 pF1KA0 CANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLC 850 860 870 880 890 900 790 800 810 820 830 840 pF1KA0 EAGYVGPRCEQQCPQGHFGPGCEQLCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGF :::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::: XP_016 EAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGF 910 920 930 940 950 960 850 860 870 880 pF1KA0 FGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAE----------------------- ::::::::::::::::::::::::::::::::::::: XP_016 FGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASC 970 980 990 1000 1010 1020 pF1KA0 ------------------------------------------------------------ XP_016 DPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLA 1030 1040 1050 1060 1070 1080 890 900 910 920 930 940 pF1KA0 ---KCLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQR .:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQR 1090 1100 1110 1120 1130 1140 950 960 970 pF1KA0 CSCPPAAACHHVTGACRCPPGFTGSGCEQGCPPG-------------------------- :::::.:::::::::::::::::::::::.:::: XP_016 CSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTC 1150 1160 1170 1180 1190 1200 980 990 1000 1010 pF1KA0 ------------------RYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQ :::::::::::::::::::::::::::::::::::::::::: XP_016 SCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQ 1210 1220 1230 1240 1250 1260 1020 1030 1040 1050 1060 1070 pF1KA0 GRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGG 1270 1280 1290 1300 1310 1320 1080 1090 1100 1110 1120 1130 pF1KA0 LCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYG ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYG 1330 1340 1350 1360 1370 1380 1140 1150 1160 1170 1180 1190 pF1KA0 QACEHRRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGGP XP_016 QACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCH 1390 1400 1410 1420 1430 1440 >-- initn: 1507 init1: 663 opt: 969 Z-score: 562.5 bits: 116.5 E(85289): 1.4e-24 Smith-Waterman score: 969; 67.4% identity (78.3% similar) in 184 aa overlap (1046-1229:1385-1559) 1020 1030 1040 1050 1060 1070 pF1KA0 QGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNG :: : ::. :: . :.::. : :..: XP_016 PGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHG 1360 1370 1380 1390 1400 1410 1080 1090 1100 1110 1120 1130 pF1KA0 GLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFY . : .: : : :. :. :: .: :: .: .:: .:.: ... :.:.:: : : :: XP_016 APCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPG-- 1420 1430 1440 1450 1460 1470 1140 1150 1160 1170 1180 1190 pF1KA0 GQACEHRRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGG ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 -------RSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGG 1480 1490 1500 1510 1520 1200 1210 1220 pF1KA0 PLRLPENPSLAQGSAGTLPASSRPTSRSGGPARH :::::::::::::::::::::::::::::::::: XP_016 PLRLPENPSLAQGSAGTLPASSRPTSRSGGPARH 1530 1540 1550 >>XP_016878162 (OMIM: 612454) PREDICTED: multiple epider (1021 aa) initn: 2696 init1: 1026 opt: 2348 Z-score: 1336.3 bits: 259.1 E(85289): 1.1e-67 Smith-Waterman score: 2650; 40.8% identity (60.5% similar) in 812 aa overlap (341-1141:23-824) 320 330 340 350 360 370 pF1KA0 CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIA :: :: : : . . ...:. .: XP_016 MVLSLTGLIAFSFLQATLALNPEDPNVCSHWESYAVTV--QESYAHPFDQIY 10 20 30 40 50 380 390 400 410 420 pF1KA0 VLQ-DELPQLFQDDDVGADEEEAELRGEHTLTEKFV-CLDDSF--GHDCSLTC-DDCRNG . .. . :. . . : :: .:. .. : . : : : ..: .: XP_016 YTRCTDILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYESGDFCIPLCTEECVHG 60 70 80 90 100 110 430 440 450 460 470 480 pF1KA0 GTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVS :. . : : : :: : :. : : .: .:: :.::::. :. .:::: : : XP_016 -RCV-SPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFR 120 130 140 150 160 490 500 510 520 530 540 pF1KA0 GTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGC : ::. : : .:: :. :.: . . : : ::: :: : .:. ::: . : : XP_016 GWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHC 170 180 190 200 210 220 550 560 570 580 590 600 pF1KA0 SEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSV .: : . : : . : :.: :. : : : : :: .: : : : : :: : XP_016 ELRCPCQNGGT--CHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHV 230 240 250 260 270 280 610 620 630 640 650 660 pF1KA0 SGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSC-GGAPCHGVTGQCRCPPGRTGEDC .:.: .: ::..:. : .::: :.:: .::. :.: .:. : .:: :.: :: : : XP_016 TGQC--HCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRC 290 300 310 320 330 340 670 680 690 700 710 720 pF1KA0 -EADCPEGRWGLGCQEICPACQ--HAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSC : :::: : :: :: :. .. : : :::: : ::. : .:.. ::.:.:: .: XP_016 QERLCPEGLHGPGCTLPCP-CDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGC 350 360 370 380 390 400 730 740 750 760 770 780 pF1KA0 QTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAIS : :.: : . :: :: :.::::. : : .: .: .::.:: :.:. : :.:. .. XP_016 QLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNG-GTCSPVD 410 420 430 440 450 460 790 800 810 820 830 840 pF1KA0 GLCLCEAGYVGPRCEQQCPQGHFGPGCEQLCQCQHGAACDHVSGACTCPAGWRGTFCEHA : : :. :. : : ::.: .: .:.. : : .::::. ..:.:.: :: : :: XP_016 GSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELP 470 480 490 500 510 520 850 860 870 880 890 900 pF1KA0 CPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAEKCLPRDVRAGCRHSGGCL :: : :::.: :.:. . .:: :.: : : :: : :: : : .: : .: XP_016 CPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCE 530 540 550 560 570 580 910 920 930 940 950 pF1KA0 NGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCS-CPPAA-ACHHVTGACRCP ::: :.:. : : : :. : :: : :..:..::: : : .. :::..: :.: XP_016 NGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECL 590 600 610 620 630 640 960 970 980 990 1000 1010 pF1KA0 PGFTGSGCEQGCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRF :::.:. :.: : : .: : :::.: :.:.:. :.:.: :..: ::. .:: : . XP_016 PGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFW 650 660 670 680 690 700 1020 1030 1040 1050 1060 1070 pF1KA0 GPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCH :: : :.:.: .::.:. :.: : :: .:. : . :: :: : ..:.:.::. : XP_016 GPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCD 710 720 730 740 750 760 1080 1090 1100 1110 1120 1130 pF1KA0 ASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQAC .:.:.: :.::.::: : :: .: .:. : : :::::. .:::: :.::: : : XP_016 HISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRC 770 780 790 800 810 820 1140 1150 1160 1170 1180 1190 pF1KA0 EHRRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGGPLRL .. XP_016 DQAALMMEELNPYTKISPALGAERHSVGAVTGIMLLLFLIVVLLGLFAWHRRRQKEKGRD 830 840 850 860 870 880 >>NP_115821 (OMIM: 612454) multiple epidermal growth fac (1044 aa) initn: 1996 init1: 1040 opt: 2348 Z-score: 1336.2 bits: 259.1 E(85289): 1.1e-67 Smith-Waterman score: 2650; 40.8% identity (60.5% similar) in 812 aa overlap (341-1141:23-824) 320 330 340 350 360 370 pF1KA0 CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIA :: :: : : . . ...:. .: NP_115 MVLSLTGLIAFSFLQATLALNPEDPNVCSHWESYAVTV--QESYAHPFDQIY 10 20 30 40 50 380 390 400 410 420 pF1KA0 VLQ-DELPQLFQDDDVGADEEEAELRGEHTLTEKFV-CLDDSF--GHDCSLTC-DDCRNG . .. . :. . . : :: .:. .. : . : : : ..: .: NP_115 YTRCTDILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYESGDFCIPLCTEECVHG 60 70 80 90 100 110 430 440 450 460 470 480 pF1KA0 GTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVS :. . : : : :: : :. : : .: .:: :.::::. :. .:::: : : NP_115 -RCV-SPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFR 120 130 140 150 160 490 500 510 520 530 540 pF1KA0 GTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGC : ::. : : .:: :. :.: . . : : ::: :: : .:. ::: . : : NP_115 GWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHC 170 180 190 200 210 220 550 560 570 580 590 600 pF1KA0 SEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSV .: : . : : . : :.: :. : : : : :: .: : : : : :: : NP_115 ELRCPCQNGGT--CHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHV 230 240 250 260 270 280 610 620 630 640 650 660 pF1KA0 SGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSC-GGAPCHGVTGQCRCPPGRTGEDC .:.: .: ::..:. : .::: :.:: .::. :.: .:. : .:: :.: :: : : NP_115 TGQC--HCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRC 290 300 310 320 330 340 670 680 690 700 710 720 pF1KA0 -EADCPEGRWGLGCQEICPACQ--HAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSC : :::: : :: :: :. .. : : :::: : ::. : .:.. ::.:.:: .: NP_115 QERLCPEGLHGPGCTLPCP-CDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGC 350 360 370 380 390 400 730 740 750 760 770 780 pF1KA0 QTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAIS : :.: : . :: :: :.::::. : : .: .: .::.:: :.:. : :.:. .. NP_115 QLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNG-GTCSPVD 410 420 430 440 450 460 790 800 810 820 830 840 pF1KA0 GLCLCEAGYVGPRCEQQCPQGHFGPGCEQLCQCQHGAACDHVSGACTCPAGWRGTFCEHA : : :. :. : : ::.: .: .:.. : : .::::. ..:.:.: :: : :: NP_115 GSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELP 470 480 490 500 510 520 850 860 870 880 890 900 pF1KA0 CPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAEKCLPRDVRAGCRHSGGCL :: : :::.: :.:. . .:: :.: : : :: : :: : : .: : .: NP_115 CPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCE 530 540 550 560 570 580 910 920 930 940 950 pF1KA0 NGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCS-CPPAA-ACHHVTGACRCP ::: :.:. : : : :. : :: : :..:..::: : : .. :::..: :.: NP_115 NGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECL 590 600 610 620 630 640 960 970 980 990 1000 1010 pF1KA0 PGFTGSGCEQGCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRF :::.:. :.: : : .: : :::.: :.:.:. :.:.: :..: ::. .:: : . NP_115 PGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFW 650 660 670 680 690 700 1020 1030 1040 1050 1060 1070 pF1KA0 GPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCH :: : :.:.: .::.:. :.: : :: .:. : . :: :: : ..:.:.::. : NP_115 GPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCD 710 720 730 740 750 760 1080 1090 1100 1110 1120 1130 pF1KA0 ASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQAC .:.:.: :.::.::: : :: .: .:. : : :::::. .:::: :.::: : : NP_115 HISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRC 770 780 790 800 810 820 1140 1150 1160 1170 1180 1190 pF1KA0 EHRRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGGPLRL .. NP_115 DQAALMMEELNPYTKISPALGAERHSVGAVTGIMLLLFLIVVLLGLFAWHRRRQKEKGRD 830 840 850 860 870 880 >>XP_016878161 (OMIM: 612454) PREDICTED: multiple epider (1044 aa) initn: 1996 init1: 1040 opt: 2348 Z-score: 1336.2 bits: 259.1 E(85289): 1.1e-67 Smith-Waterman score: 2650; 40.8% identity (60.5% similar) in 812 aa overlap (341-1141:23-824) 320 330 340 350 360 370 pF1KA0 CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIA :: :: : : . . ...:. .: XP_016 MVLSLTGLIAFSFLQATLALNPEDPNVCSHWESYAVTV--QESYAHPFDQIY 10 20 30 40 50 380 390 400 410 420 pF1KA0 VLQ-DELPQLFQDDDVGADEEEAELRGEHTLTEKFV-CLDDSF--GHDCSLTC-DDCRNG . .. . :. . . : :: .:. .. : . : : : ..: .: XP_016 YTRCTDILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYESGDFCIPLCTEECVHG 60 70 80 90 100 110 430 440 450 460 470 480 pF1KA0 GTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVS :. . : : : :: : :. : : .: .:: :.::::. :. .:::: : : XP_016 -RCV-SPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFR 120 130 140 150 160 490 500 510 520 530 540 pF1KA0 GTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGC : ::. : : .:: :. :.: . . : : ::: :: : .:. ::: . : : XP_016 GWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHC 170 180 190 200 210 220 550 560 570 580 590 600 pF1KA0 SEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSV .: : . : : . : :.: :. : : : : :: .: : : : : :: : XP_016 ELRCPCQNGGT--CHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHV 230 240 250 260 270 280 610 620 630 640 650 660 pF1KA0 SGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSC-GGAPCHGVTGQCRCPPGRTGEDC .:.: .: ::..:. : .::: :.:: .::. :.: .:. : .:: :.: :: : : XP_016 TGQC--HCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRC 290 300 310 320 330 340 670 680 690 700 710 720 pF1KA0 -EADCPEGRWGLGCQEICPACQ--HAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSC : :::: : :: :: :. .. : : :::: : ::. : .:.. ::.:.:: .: XP_016 QERLCPEGLHGPGCTLPCP-CDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGC 350 360 370 380 390 400 730 740 750 760 770 780 pF1KA0 QTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAIS : :.: : . :: :: :.::::. : : .: .: .::.:: :.:. : :.:. .. XP_016 QLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNG-GTCSPVD 410 420 430 440 450 460 790 800 810 820 830 840 pF1KA0 GLCLCEAGYVGPRCEQQCPQGHFGPGCEQLCQCQHGAACDHVSGACTCPAGWRGTFCEHA : : :. :. : : ::.: .: .:.. : : .::::. ..:.:.: :: : :: XP_016 GSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELP 470 480 490 500 510 520 850 860 870 880 890 900 pF1KA0 CPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAEKCLPRDVRAGCRHSGGCL :: : :::.: :.:. . .:: :.: : : :: : :: : : .: : .: XP_016 CPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCE 530 540 550 560 570 580 910 920 930 940 950 pF1KA0 NGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCS-CPPAA-ACHHVTGACRCP ::: :.:. : : : :. : :: : :..:..::: : : .. :::..: :.: XP_016 NGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECL 590 600 610 620 630 640 960 970 980 990 1000 1010 pF1KA0 PGFTGSGCEQGCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRF :::.:. :.: : : .: : :::.: :.:.:. :.:.: :..: ::. .:: : . XP_016 PGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFW 650 660 670 680 690 700 1020 1030 1040 1050 1060 1070 pF1KA0 GPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCH :: : :.:.: .::.:. :.: : :: .:. : . :: :: : ..:.:.::. : XP_016 GPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCD 710 720 730 740 750 760 1080 1090 1100 1110 1120 1130 pF1KA0 ASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQAC .:.:.: :.::.::: : :: .: .:. : : :::::. .:::: :.::: : : XP_016 HISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRC 770 780 790 800 810 820 1140 1150 1160 1170 1180 1190 pF1KA0 EHRRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGGPLRL .. XP_016 DQAALMMEELNPYTKISPALGAERHSVGAVTGIMLLLFLIVVLLGLFAWHRRRQKEKGRD 830 840 850 860 870 880 1229 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 10:21:20 2016 done: Thu Nov 3 10:21:22 2016 Total Scan time: 13.340 Total Display time: 0.560 Function used was FASTA [36.3.4 Apr, 2011]