FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0819, 1918 aa 1>>>pF1KA0819 1918 - 1918 aa - 1918 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 18.2623+/-0.000512; mu= -37.3002+/- 0.032 mean_var=679.6999+/-136.235, 0's: 0 Z-trim(123.6): 166 B-trim: 66 in 1/61 Lambda= 0.049194 statistics sampled from 43648 (43830) to 43648 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.771), E-opt: 0.2 (0.514), width: 16 Scan time: 24.880 The best scores are: opt bits E(85289) XP_016884371 (OMIM: 608882) PREDICTED: protein-met (2036) 6872 504.2 5.6e-141 XP_016884370 (OMIM: 608882) PREDICTED: protein-met (2057) 6872 504.2 5.6e-141 XP_016884368 (OMIM: 608882) PREDICTED: protein-met (2057) 6872 504.2 5.6e-141 XP_016884369 (OMIM: 608882) PREDICTED: protein-met (2057) 6872 504.2 5.6e-141 XP_005261319 (OMIM: 608882) PREDICTED: protein-met (2002) 6866 503.8 7.4e-141 NP_056056 (OMIM: 608882) protein-methionine sulfox (2002) 6866 503.8 7.4e-141 XP_016884367 (OMIM: 608882) PREDICTED: protein-met (2104) 6637 487.5 6e-136 NP_001116203 (OMIM: 608882) protein-methionine sul ( 966) 6173 454.5 2.5e-126 XP_016884376 (OMIM: 608882) PREDICTED: protein-met ( 965) 6170 454.3 2.8e-126 XP_011544444 (OMIM: 608882) PREDICTED: protein-met (2175) 6057 446.4 1.5e-123 XP_016884361 (OMIM: 608882) PREDICTED: protein-met (2192) 5322 394.2 7.8e-108 XP_016884364 (OMIM: 608882) PREDICTED: protein-met (2173) 4938 366.9 1.2e-99 XP_011544448 (OMIM: 608882) PREDICTED: protein-met (1117) 4918 365.4 1.8e-99 NP_001129476 (OMIM: 608882) protein-methionine sul (1073) 4917 365.3 1.8e-99 XP_016884366 (OMIM: 608882) PREDICTED: protein-met (2142) 4919 365.6 3.1e-99 XP_016884365 (OMIM: 608882) PREDICTED: protein-met (2163) 4919 365.6 3.1e-99 XP_016884362 (OMIM: 608882) PREDICTED: protein-met (2188) 4918 365.5 3.3e-99 XP_011544441 (OMIM: 608882) PREDICTED: protein-met (2192) 4918 365.5 3.3e-99 XP_016884360 (OMIM: 608882) PREDICTED: protein-met (2208) 4918 365.5 3.4e-99 XP_016884357 (OMIM: 608882) PREDICTED: protein-met (2209) 4918 365.5 3.4e-99 XP_016884356 (OMIM: 608882) PREDICTED: protein-met (2209) 4918 365.5 3.4e-99 XP_016884358 (OMIM: 608882) PREDICTED: protein-met (2209) 4918 365.5 3.4e-99 XP_016884359 (OMIM: 608882) PREDICTED: protein-met (2209) 4918 365.5 3.4e-99 XP_016884354 (OMIM: 608882) PREDICTED: protein-met (2209) 4918 365.5 3.4e-99 XP_016884355 (OMIM: 608882) PREDICTED: protein-met (2209) 4918 365.5 3.4e-99 XP_011544439 (OMIM: 608882) PREDICTED: protein-met (2209) 4918 365.5 3.4e-99 XP_016884363 (OMIM: 608882) PREDICTED: protein-met (2181) 4917 365.4 3.5e-99 XP_016884374 (OMIM: 608882) PREDICTED: protein-met (1308) 4907 364.7 3.6e-99 XP_016884375 (OMIM: 608882) PREDICTED: protein-met (1308) 4907 364.7 3.6e-99 XP_016884373 (OMIM: 608882) PREDICTED: protein-met (1757) 4907 364.7 4.7e-99 XP_016884372 (OMIM: 608882) PREDICTED: protein-met (1909) 4907 364.7 5.1e-99 NP_001333228 (OMIM: 608881) protein-methionine sul (1103) 3330 252.7 1.5e-65 NP_001333223 (OMIM: 608881) protein-methionine sul (1103) 3330 252.7 1.5e-65 NP_001333227 (OMIM: 608881) protein-methionine sul (1103) 3330 252.7 1.5e-65 NP_001333226 (OMIM: 608881) protein-methionine sul (1103) 3330 252.7 1.5e-65 NP_001333222 (OMIM: 608881) protein-methionine sul (1103) 3330 252.7 1.5e-65 XP_016874080 (OMIM: 608881) PREDICTED: protein-met (1103) 3330 252.7 1.5e-65 NP_001269593 (OMIM: 608881) protein-methionine sul (1103) 3330 252.7 1.5e-65 NP_001333224 (OMIM: 608881) protein-methionine sul (1103) 3330 252.7 1.5e-65 NP_001333225 (OMIM: 608881) protein-methionine sul (1103) 3330 252.7 1.5e-65 NP_001269592 (OMIM: 608881) protein-methionine sul (1124) 3330 252.7 1.5e-65 XP_016874079 (OMIM: 608881) PREDICTED: protein-met (1124) 3330 252.7 1.5e-65 NP_001333221 (OMIM: 608881) protein-methionine sul (1124) 3330 252.7 1.5e-65 NP_055447 (OMIM: 608881) protein-methionine sulfox (1124) 3330 252.7 1.5e-65 XP_016874078 (OMIM: 608881) PREDICTED: protein-met (1124) 3330 252.7 1.5e-65 XP_011518793 (OMIM: 608881) PREDICTED: protein-met (1191) 3330 252.7 1.6e-65 XP_011518792 (OMIM: 608881) PREDICTED: protein-met (1204) 3330 252.7 1.6e-65 NP_001269594 (OMIM: 608881) protein-methionine sul ( 934) 3325 252.3 1.7e-65 NP_001269596 (OMIM: 608881) protein-methionine sul ( 955) 3325 252.3 1.7e-65 NP_001269595 (OMIM: 608881) protein-methionine sul ( 976) 3325 252.3 1.7e-65 >>XP_016884371 (OMIM: 608882) PREDICTED: protein-methion (2036 aa) initn: 12312 init1: 6713 opt: 6872 Z-score: 2652.0 bits: 504.2 E(85289): 5.6e-141 Smith-Waterman score: 11887; 93.9% identity (93.9% similar) in 1950 aa overlap (1-1832:1-1950) 10 20 30 40 50 60 pF1KA0 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGG 910 920 930 940 950 960 970 980 990 1000 1010 pF1KA0 VPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSE-- :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSEAG 970 980 990 1000 1010 1020 pF1KA0 ------------------------------------------------------------ XP_016 NQRLQQVMHAADPLEIQADVHWTHIREREEEERMAPASESSASGAPLDENDLEEDVDSEP 1030 1040 1050 1060 1070 1080 1020 1030 1040 1050 pF1KA0 ----------------------DQHWSDSPSDADRELRLPCPAEGEAELELRVSEDEEKL :::::::::::::::::::::::::::::::::::::: XP_016 AEIEGEAAEDGDPGDTGAELDDDQHWSDSPSDADRELRLPCPAEGEAELELRVSEDEEKL 1090 1100 1110 1120 1130 1140 1060 1070 1080 1090 1100 1110 pF1KA0 PASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGPQLPPVPAATQEKSPEERLFPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGPQLPPVPAATQEKSPEERLFPE 1150 1160 1170 1180 1190 1200 1120 1130 1140 1150 1160 1170 pF1KA0 PLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSPGSPQPRPPVAASTPPPSPLPI ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: XP_016 PLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSPGSPQPQPPVAASTPPPSPLPI 1210 1220 1230 1240 1250 1260 1180 1190 1200 1210 1220 1230 pF1KA0 CSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRR 1270 1280 1290 1300 1310 1320 1240 1250 1260 1270 1280 1290 pF1KA0 SDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLL 1330 1340 1350 1360 1370 1380 1300 1310 1320 1330 1340 1350 pF1KA0 KPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTL 1390 1400 1410 1420 1430 1440 1360 1370 1380 1390 1400 1410 pF1KA0 GSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPRE 1450 1460 1470 1480 1490 1500 1420 1430 1440 1450 1460 1470 pF1KA0 PAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWPRPEKPRHPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWPRPEKPRHPP 1510 1520 1530 1540 1550 1560 1480 1490 1500 1510 1520 1530 pF1KA0 LAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRDAMARQLSRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRDAMARQLSRM 1570 1580 1590 1600 1610 1620 1540 1550 1560 1570 1580 1590 pF1KA0 QQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSG 1630 1640 1650 1660 1670 1680 1600 1610 1620 1630 1640 1650 pF1KA0 GPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGRPPEKPSSNLLEEAAAKPKSLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGRPPEKPSSNLLEEAAAKPKSLW 1690 1700 1710 1720 1730 1740 1660 1670 1680 1690 1700 1710 pF1KA0 KSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLS 1750 1760 1770 1780 1790 1800 1720 1730 1740 1750 pF1KA0 SDDVLEKSSQKSRRE-----------------PRTYTEEELNAKLTRRVQKAARRQAKQE ::::::::::::::: :::::::::::::::::::::::::::: XP_016 SDDVLEKSSQKSRRESIYVPHALAFRRSCASKPRTYTEEELNAKLTRRVQKAARRQAKQE 1810 1820 1830 1840 1850 1860 1760 1770 1780 1790 1800 pF1KA0 ELKRLHRAQIIQRQLQQVEERQRRLEERGVAVEKALRGEA-----------------GMG :::::::::::::::::::::::::::::::::::::::: ::: XP_016 ELKRLHRAQIIQRQLQQVEERQRRLEERGVAVEKALRGEADYWGESYYSDLIDLHLGGMG 1870 1880 1890 1900 1910 1920 1810 1820 1830 1840 1850 1860 pF1KA0 KKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELEDRQSRLQQELRERMAVEDHLKT :::::::::::::::::::::::::::::: XP_016 KKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELEDRQSRLQQELRERMAVEDHLKT 1930 1940 1950 1960 1970 1980 >-- initn: 533 init1: 533 opt: 533 Z-score: 220.6 bits: 54.3 E(85289): 1.5e-05 Smith-Waterman score: 533; 100.0% identity (100.0% similar) in 86 aa overlap (1833-1918:1951-2036) 1810 1820 1830 1840 1850 1860 pF1KA0 KKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELEDRQSRLQQELRERMAVEDHLKT :::::::::::::::::::::::::::::: XP_016 KKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELEDRQSRLQQELRERMAVEDHLKT 1930 1940 1950 1960 1970 1980 1870 1880 1890 1900 1910 pF1KA0 EEELSEEKQILNEMLEVVEQRDSLVALLEEQRLREREEDKDLEAAMLSKGFSLNWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEELSEEKQILNEMLEVVEQRDSLVALLEEQRLREREEDKDLEAAMLSKGFSLNWS 1990 2000 2010 2020 2030 >>XP_016884370 (OMIM: 608882) PREDICTED: protein-methion (2057 aa) initn: 12312 init1: 6713 opt: 6872 Z-score: 2651.9 bits: 504.2 E(85289): 5.6e-141 Smith-Waterman score: 11708; 92.8% identity (92.9% similar) in 1950 aa overlap (1-1811:1-1950) 10 20 30 40 50 60 pF1KA0 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGG 910 920 930 940 950 960 970 980 990 1000 1010 pF1KA0 VPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSE-- :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSEAG 970 980 990 1000 1010 1020 pF1KA0 ------------------------------------------------------------ XP_016 NQRLQQVMHAADPLEIQADVHWTHIREREEEERMAPASESSASGVPDLPSIRHAAVQAWL 1030 1040 1050 1060 1070 1080 1020 1030 pF1KA0 -------------------------------------------DQHWSDSPSDADRELRL ::::::::::::::::: XP_016 ETVSGAPLDENDLEEDVDSEPAEIEGEAAEDGDPGDTGAELDDDQHWSDSPSDADRELRL 1090 1100 1110 1120 1130 1140 1040 1050 1060 1070 1080 1090 pF1KA0 PCPAEGEAELELRVSEDEEKLPASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PCPAEGEAELELRVSEDEEKLPASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGP 1150 1160 1170 1180 1190 1200 1100 1110 1120 1130 1140 1150 pF1KA0 QLPPVPAATQEKSPEERLFPEPLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLPPVPAATQEKSPEERLFPEPLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSP 1210 1220 1230 1240 1250 1260 1160 1170 1180 1190 1200 1210 pF1KA0 GSPQPRPPVAASTPPPSPLPICSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQ :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSPQPQPPVAASTPPPSPLPICSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQ 1270 1280 1290 1300 1310 1320 1220 1230 1240 1250 1260 1270 pF1KA0 SQSDTKDRLGSPLAVDEALRRSDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQSDTKDRLGSPLAVDEALRRSDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFR 1330 1340 1350 1360 1370 1380 1280 1290 1300 1310 1320 1330 pF1KA0 PVSLKSYSVEKSPQDEGLHLLKPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PVSLKSYSVEKSPQDEGLHLLKPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEER 1390 1400 1410 1420 1430 1440 1340 1350 1360 1370 1380 1390 pF1KA0 RELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREA 1450 1460 1470 1480 1490 1500 1400 1410 1420 1430 1440 1450 pF1KA0 EPNASVVPPPLPATWMRPPREPAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPNASVVPPPLPATWMRPPREPAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSL 1510 1520 1530 1540 1550 1560 1460 1470 1480 1490 1500 1510 pF1KA0 QEKFFTPPSCWPRPEKPRHPPLAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QEKFFTPPSCWPRPEKPRHPPLAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRA 1570 1580 1590 1600 1610 1620 1520 1530 1540 1550 1560 1570 pF1KA0 REKSVKSQALRDAMARQLSRMQQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REKSVKSQALRDAMARQLSRMQQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSE 1630 1640 1650 1660 1670 1680 1580 1590 1600 1610 1620 1630 pF1KA0 EPTLKHEATSEEVLSPPSDSGGPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPTLKHEATSEEVLSPPSDSGGPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGR 1690 1700 1710 1720 1730 1740 1640 1650 1660 1670 1680 1690 pF1KA0 PPEKPSSNLLEEAAAKPKSLWKSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPEKPSSNLLEEAAAKPKSLWKSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLP 1750 1760 1770 1780 1790 1800 1700 1710 1720 1730 pF1KA0 VVRAELQLRRQLSFSEDSDLSSDDVLEKSSQKSRRE-----------------PRTYTEE :::::::::::::::::::::::::::::::::::: ::::::: XP_016 VVRAELQLRRQLSFSEDSDLSSDDVLEKSSQKSRRESIYVPHALAFRRSCASKPRTYTEE 1810 1820 1830 1840 1850 1860 1740 1750 1760 1770 1780 1790 pF1KA0 ELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQVEERQRRLEERGVAVEKALRGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQVEERQRRLEERGVAVEKALRGE 1870 1880 1890 1900 1910 1920 1800 1810 1820 1830 1840 pF1KA0 A-----------------GMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELED : :::::::::::: XP_016 ADYWGESYYSDLIDLHLGGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELED 1930 1940 1950 1960 1970 1980 >-- initn: 670 init1: 670 opt: 670 Z-score: 273.0 bits: 64.0 E(85289): 1.8e-08 Smith-Waterman score: 670; 100.0% identity (100.0% similar) in 107 aa overlap (1812-1918:1951-2057) 1790 1800 1810 1820 1830 1840 pF1KA0 RRLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELED :::::::::::::::::::::::::::::: XP_016 ADYWGESYYSDLIDLHLGGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELED 1930 1940 1950 1960 1970 1980 1850 1860 1870 1880 1890 1900 pF1KA0 RQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLREREED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLREREED 1990 2000 2010 2020 2030 2040 1910 pF1KA0 KDLEAAMLSKGFSLNWS ::::::::::::::::: XP_016 KDLEAAMLSKGFSLNWS 2050 >>XP_016884368 (OMIM: 608882) PREDICTED: protein-methion (2057 aa) initn: 12312 init1: 6713 opt: 6872 Z-score: 2651.9 bits: 504.2 E(85289): 5.6e-141 Smith-Waterman score: 11708; 92.8% identity (92.9% similar) in 1950 aa overlap (1-1811:1-1950) 10 20 30 40 50 60 pF1KA0 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGG 910 920 930 940 950 960 970 980 990 1000 1010 pF1KA0 VPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSE-- :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSEAG 970 980 990 1000 1010 1020 pF1KA0 ------------------------------------------------------------ XP_016 NQRLQQVMHAADPLEIQADVHWTHIREREEEERMAPASESSASGVPDLPSIRHAAVQAWL 1030 1040 1050 1060 1070 1080 1020 1030 pF1KA0 -------------------------------------------DQHWSDSPSDADRELRL ::::::::::::::::: XP_016 ETVSGAPLDENDLEEDVDSEPAEIEGEAAEDGDPGDTGAELDDDQHWSDSPSDADRELRL 1090 1100 1110 1120 1130 1140 1040 1050 1060 1070 1080 1090 pF1KA0 PCPAEGEAELELRVSEDEEKLPASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PCPAEGEAELELRVSEDEEKLPASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGP 1150 1160 1170 1180 1190 1200 1100 1110 1120 1130 1140 1150 pF1KA0 QLPPVPAATQEKSPEERLFPEPLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLPPVPAATQEKSPEERLFPEPLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSP 1210 1220 1230 1240 1250 1260 1160 1170 1180 1190 1200 1210 pF1KA0 GSPQPRPPVAASTPPPSPLPICSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQ :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSPQPQPPVAASTPPPSPLPICSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQ 1270 1280 1290 1300 1310 1320 1220 1230 1240 1250 1260 1270 pF1KA0 SQSDTKDRLGSPLAVDEALRRSDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQSDTKDRLGSPLAVDEALRRSDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFR 1330 1340 1350 1360 1370 1380 1280 1290 1300 1310 1320 1330 pF1KA0 PVSLKSYSVEKSPQDEGLHLLKPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PVSLKSYSVEKSPQDEGLHLLKPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEER 1390 1400 1410 1420 1430 1440 1340 1350 1360 1370 1380 1390 pF1KA0 RELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREA 1450 1460 1470 1480 1490 1500 1400 1410 1420 1430 1440 1450 pF1KA0 EPNASVVPPPLPATWMRPPREPAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPNASVVPPPLPATWMRPPREPAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSL 1510 1520 1530 1540 1550 1560 1460 1470 1480 1490 1500 1510 pF1KA0 QEKFFTPPSCWPRPEKPRHPPLAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QEKFFTPPSCWPRPEKPRHPPLAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRA 1570 1580 1590 1600 1610 1620 1520 1530 1540 1550 1560 1570 pF1KA0 REKSVKSQALRDAMARQLSRMQQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REKSVKSQALRDAMARQLSRMQQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSE 1630 1640 1650 1660 1670 1680 1580 1590 1600 1610 1620 1630 pF1KA0 EPTLKHEATSEEVLSPPSDSGGPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPTLKHEATSEEVLSPPSDSGGPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGR 1690 1700 1710 1720 1730 1740 1640 1650 1660 1670 1680 1690 pF1KA0 PPEKPSSNLLEEAAAKPKSLWKSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPEKPSSNLLEEAAAKPKSLWKSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLP 1750 1760 1770 1780 1790 1800 1700 1710 1720 1730 pF1KA0 VVRAELQLRRQLSFSEDSDLSSDDVLEKSSQKSRRE-----------------PRTYTEE :::::::::::::::::::::::::::::::::::: ::::::: XP_016 VVRAELQLRRQLSFSEDSDLSSDDVLEKSSQKSRRESIYVPHALAFRRSCASKPRTYTEE 1810 1820 1830 1840 1850 1860 1740 1750 1760 1770 1780 1790 pF1KA0 ELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQVEERQRRLEERGVAVEKALRGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQVEERQRRLEERGVAVEKALRGE 1870 1880 1890 1900 1910 1920 1800 1810 1820 1830 1840 pF1KA0 A-----------------GMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELED : :::::::::::: XP_016 ADYWGESYYSDLIDLHLGGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELED 1930 1940 1950 1960 1970 1980 >-- initn: 670 init1: 670 opt: 670 Z-score: 273.0 bits: 64.0 E(85289): 1.8e-08 Smith-Waterman score: 670; 100.0% identity (100.0% similar) in 107 aa overlap (1812-1918:1951-2057) 1790 1800 1810 1820 1830 1840 pF1KA0 RRLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELED :::::::::::::::::::::::::::::: XP_016 ADYWGESYYSDLIDLHLGGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELED 1930 1940 1950 1960 1970 1980 1850 1860 1870 1880 1890 1900 pF1KA0 RQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLREREED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLREREED 1990 2000 2010 2020 2030 2040 1910 pF1KA0 KDLEAAMLSKGFSLNWS ::::::::::::::::: XP_016 KDLEAAMLSKGFSLNWS 2050 >>XP_016884369 (OMIM: 608882) PREDICTED: protein-methion (2057 aa) initn: 12312 init1: 6713 opt: 6872 Z-score: 2651.9 bits: 504.2 E(85289): 5.6e-141 Smith-Waterman score: 11708; 92.8% identity (92.9% similar) in 1950 aa overlap (1-1811:1-1950) 10 20 30 40 50 60 pF1KA0 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGG 910 920 930 940 950 960 970 980 990 1000 1010 pF1KA0 VPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSE-- :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSEAG 970 980 990 1000 1010 1020 pF1KA0 ------------------------------------------------------------ XP_016 NQRLQQVMHAADPLEIQADVHWTHIREREEEERMAPASESSASGVPDLPSIRHAAVQAWL 1030 1040 1050 1060 1070 1080 1020 1030 pF1KA0 -------------------------------------------DQHWSDSPSDADRELRL ::::::::::::::::: XP_016 ETVSGAPLDENDLEEDVDSEPAEIEGEAAEDGDPGDTGAELDDDQHWSDSPSDADRELRL 1090 1100 1110 1120 1130 1140 1040 1050 1060 1070 1080 1090 pF1KA0 PCPAEGEAELELRVSEDEEKLPASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PCPAEGEAELELRVSEDEEKLPASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGP 1150 1160 1170 1180 1190 1200 1100 1110 1120 1130 1140 1150 pF1KA0 QLPPVPAATQEKSPEERLFPEPLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLPPVPAATQEKSPEERLFPEPLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSP 1210 1220 1230 1240 1250 1260 1160 1170 1180 1190 1200 1210 pF1KA0 GSPQPRPPVAASTPPPSPLPICSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQ :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSPQPQPPVAASTPPPSPLPICSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQ 1270 1280 1290 1300 1310 1320 1220 1230 1240 1250 1260 1270 pF1KA0 SQSDTKDRLGSPLAVDEALRRSDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQSDTKDRLGSPLAVDEALRRSDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFR 1330 1340 1350 1360 1370 1380 1280 1290 1300 1310 1320 1330 pF1KA0 PVSLKSYSVEKSPQDEGLHLLKPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PVSLKSYSVEKSPQDEGLHLLKPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEER 1390 1400 1410 1420 1430 1440 1340 1350 1360 1370 1380 1390 pF1KA0 RELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREA 1450 1460 1470 1480 1490 1500 1400 1410 1420 1430 1440 1450 pF1KA0 EPNASVVPPPLPATWMRPPREPAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPNASVVPPPLPATWMRPPREPAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSL 1510 1520 1530 1540 1550 1560 1460 1470 1480 1490 1500 1510 pF1KA0 QEKFFTPPSCWPRPEKPRHPPLAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QEKFFTPPSCWPRPEKPRHPPLAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRA 1570 1580 1590 1600 1610 1620 1520 1530 1540 1550 1560 1570 pF1KA0 REKSVKSQALRDAMARQLSRMQQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REKSVKSQALRDAMARQLSRMQQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSE 1630 1640 1650 1660 1670 1680 1580 1590 1600 1610 1620 1630 pF1KA0 EPTLKHEATSEEVLSPPSDSGGPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPTLKHEATSEEVLSPPSDSGGPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGR 1690 1700 1710 1720 1730 1740 1640 1650 1660 1670 1680 1690 pF1KA0 PPEKPSSNLLEEAAAKPKSLWKSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPEKPSSNLLEEAAAKPKSLWKSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLP 1750 1760 1770 1780 1790 1800 1700 1710 1720 1730 pF1KA0 VVRAELQLRRQLSFSEDSDLSSDDVLEKSSQKSRRE-----------------PRTYTEE :::::::::::::::::::::::::::::::::::: ::::::: XP_016 VVRAELQLRRQLSFSEDSDLSSDDVLEKSSQKSRRESIYVPHALAFRRSCASKPRTYTEE 1810 1820 1830 1840 1850 1860 1740 1750 1760 1770 1780 1790 pF1KA0 ELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQVEERQRRLEERGVAVEKALRGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQVEERQRRLEERGVAVEKALRGE 1870 1880 1890 1900 1910 1920 1800 1810 1820 1830 1840 pF1KA0 A-----------------GMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELED : :::::::::::: XP_016 ADYWGESYYSDLIDLHLGGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELED 1930 1940 1950 1960 1970 1980 >-- initn: 670 init1: 670 opt: 670 Z-score: 273.0 bits: 64.0 E(85289): 1.8e-08 Smith-Waterman score: 670; 100.0% identity (100.0% similar) in 107 aa overlap (1812-1918:1951-2057) 1790 1800 1810 1820 1830 1840 pF1KA0 RRLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELED :::::::::::::::::::::::::::::: XP_016 ADYWGESYYSDLIDLHLGGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELED 1930 1940 1950 1960 1970 1980 1850 1860 1870 1880 1890 1900 pF1KA0 RQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLREREED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLREREED 1990 2000 2010 2020 2030 2040 1910 pF1KA0 KDLEAAMLSKGFSLNWS ::::::::::::::::: XP_016 KDLEAAMLSKGFSLNWS 2050 >>XP_005261319 (OMIM: 608882) PREDICTED: protein-methion (2002 aa) initn: 12747 init1: 6713 opt: 6866 Z-score: 2649.8 bits: 503.8 E(85289): 7.4e-141 Smith-Waterman score: 12187; 95.6% identity (95.7% similar) in 1950 aa overlap (1-1866:1-1950) 10 20 30 40 50 60 pF1KA0 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGG 910 920 930 940 950 960 970 980 990 1000 1010 pF1KA0 VPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSE-- :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSEAG 970 980 990 1000 1010 1020 pF1KA0 ------------------------------------------------------------ XP_005 NQRLQQVMHAADPLEIQADVHWTHIREREEEERMAPASESSASGAPLDENDLEEDVDSEP 1030 1040 1050 1060 1070 1080 1020 1030 1040 1050 pF1KA0 ----------------------DQHWSDSPSDADRELRLPCPAEGEAELELRVSEDEEKL :::::::::::::::::::::::::::::::::::::: XP_005 AEIEGEAAEDGDPGDTGAELDDDQHWSDSPSDADRELRLPCPAEGEAELELRVSEDEEKL 1090 1100 1110 1120 1130 1140 1060 1070 1080 1090 1100 1110 pF1KA0 PASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGPQLPPVPAATQEKSPEERLFPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGPQLPPVPAATQEKSPEERLFPE 1150 1160 1170 1180 1190 1200 1120 1130 1140 1150 1160 1170 pF1KA0 PLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSPGSPQPRPPVAASTPPPSPLPI ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: XP_005 PLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSPGSPQPQPPVAASTPPPSPLPI 1210 1220 1230 1240 1250 1260 1180 1190 1200 1210 1220 1230 pF1KA0 CSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRR 1270 1280 1290 1300 1310 1320 1240 1250 1260 1270 1280 1290 pF1KA0 SDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLL 1330 1340 1350 1360 1370 1380 1300 1310 1320 1330 1340 1350 pF1KA0 KPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTL 1390 1400 1410 1420 1430 1440 1360 1370 1380 1390 1400 1410 pF1KA0 GSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPRE 1450 1460 1470 1480 1490 1500 1420 1430 1440 1450 1460 1470 pF1KA0 PAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWPRPEKPRHPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWPRPEKPRHPP 1510 1520 1530 1540 1550 1560 1480 1490 1500 1510 1520 1530 pF1KA0 LAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRDAMARQLSRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRDAMARQLSRM 1570 1580 1590 1600 1610 1620 1540 1550 1560 1570 1580 1590 pF1KA0 QQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSG 1630 1640 1650 1660 1670 1680 1600 1610 1620 1630 1640 1650 pF1KA0 GPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGRPPEKPSSNLLEEAAAKPKSLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGRPPEKPSSNLLEEAAAKPKSLW 1690 1700 1710 1720 1730 1740 1660 1670 1680 1690 1700 1710 pF1KA0 KSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLS 1750 1760 1770 1780 1790 1800 1720 1730 1740 1750 1760 1770 pF1KA0 SDDVLEKSSQKSRREPRTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDDVLEKSSQKSRREPRTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQ 1810 1820 1830 1840 1850 1860 1780 1790 1800 1810 1820 1830 pF1KA0 VEERQRRLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VEERQRRLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARE 1870 1880 1890 1900 1910 1920 1840 1850 1860 1870 1880 1890 pF1KA0 LELEDRQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLR :::::::::::::::::::::::::::::: XP_005 LELEDRQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLR 1930 1940 1950 1960 1970 1980 >>NP_056056 (OMIM: 608882) protein-methionine sulfoxide (2002 aa) initn: 12747 init1: 6713 opt: 6866 Z-score: 2649.8 bits: 503.8 E(85289): 7.4e-141 Smith-Waterman score: 12187; 95.6% identity (95.7% similar) in 1950 aa overlap (1-1866:1-1950) 10 20 30 40 50 60 pF1KA0 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGG 910 920 930 940 950 960 970 980 990 1000 1010 pF1KA0 VPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSE-- :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 VPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSEAG 970 980 990 1000 1010 1020 pF1KA0 ------------------------------------------------------------ NP_056 NQRLQQVMHAADPLEIQADVHWTHIREREEEERMAPASESSASGAPLDENDLEEDVDSEP 1030 1040 1050 1060 1070 1080 1020 1030 1040 1050 pF1KA0 ----------------------DQHWSDSPSDADRELRLPCPAEGEAELELRVSEDEEKL :::::::::::::::::::::::::::::::::::::: NP_056 AEIEGEAAEDGDPGDTGAELDDDQHWSDSPSDADRELRLPCPAEGEAELELRVSEDEEKL 1090 1100 1110 1120 1130 1140 1060 1070 1080 1090 1100 1110 pF1KA0 PASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGPQLPPVPAATQEKSPEERLFPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 PASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGPQLPPVPAATQEKSPEERLFPE 1150 1160 1170 1180 1190 1200 1120 1130 1140 1150 1160 1170 pF1KA0 PLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSPGSPQPRPPVAASTPPPSPLPI ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: NP_056 PLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSPGSPQPQPPVAASTPPPSPLPI 1210 1220 1230 1240 1250 1260 1180 1190 1200 1210 1220 1230 pF1KA0 CSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 CSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRR 1270 1280 1290 1300 1310 1320 1240 1250 1260 1270 1280 1290 pF1KA0 SDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLL 1330 1340 1350 1360 1370 1380 1300 1310 1320 1330 1340 1350 pF1KA0 KPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTL 1390 1400 1410 1420 1430 1440 1360 1370 1380 1390 1400 1410 pF1KA0 GSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPRE 1450 1460 1470 1480 1490 1500 1420 1430 1440 1450 1460 1470 pF1KA0 PAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWPRPEKPRHPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 PAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWPRPEKPRHPP 1510 1520 1530 1540 1550 1560 1480 1490 1500 1510 1520 1530 pF1KA0 LAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRDAMARQLSRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRDAMARQLSRM 1570 1580 1590 1600 1610 1620 1540 1550 1560 1570 1580 1590 pF1KA0 QQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 QQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSG 1630 1640 1650 1660 1670 1680 1600 1610 1620 1630 1640 1650 pF1KA0 GPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGRPPEKPSSNLLEEAAAKPKSLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGRPPEKPSSNLLEEAAAKPKSLW 1690 1700 1710 1720 1730 1740 1660 1670 1680 1690 1700 1710 pF1KA0 KSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLS 1750 1760 1770 1780 1790 1800 1720 1730 1740 1750 1760 1770 pF1KA0 SDDVLEKSSQKSRREPRTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SDDVLEKSSQKSRREPRTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQ 1810 1820 1830 1840 1850 1860 1780 1790 1800 1810 1820 1830 pF1KA0 VEERQRRLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 VEERQRRLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARE 1870 1880 1890 1900 1910 1920 1840 1850 1860 1870 1880 1890 pF1KA0 LELEDRQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLR :::::::::::::::::::::::::::::: NP_056 LELEDRQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLR 1930 1940 1950 1960 1970 1980 >>XP_016884367 (OMIM: 608882) PREDICTED: protein-methion (2104 aa) initn: 7337 init1: 6595 opt: 6637 Z-score: 2561.6 bits: 487.5 E(85289): 6e-136 Smith-Waterman score: 11447; 90.6% identity (90.6% similar) in 1982 aa overlap (121-1916:121-2102) 100 110 120 130 140 150 pF1KA0 IIGAGPCGLRTAIDLSLLGAKVVVIEKRDAFSRNNVLHLWPFTIHDLRGLGAKKFYGKFC :::::::::::::::::::::::::::::: XP_016 IIGAGPCGLRTAIDLSLLGAKVVVIEKRDAFSRNNVLHLWPFTIHDLRGLGAKKFYGKFC 100 110 120 130 140 150 160 170 180 190 200 210 pF1KA0 AGAIDHISIRQLQLILLKVALILGIEIHVNVEFQGLIQPPEDQENERIGWRALVHPKTHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGAIDHISIRQLQLILLKVALILGIEIHVNVEFQGLIQPPEDQENERIGWRALVHPKTHP 160 170 180 190 200 210 220 230 240 250 260 270 pF1KA0 VSEYEFEVIIGGDGRRNTLEGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSEYEFEVIIGGDGRRNTLEGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIF 220 230 240 250 260 270 280 290 300 310 320 330 pF1KA0 NQKFFQELREATGIDLENIVYYKDDTHYFVMTAKKQSLLDKGVILHDYADTELLLSRENV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NQKFFQELREATGIDLENIVYYKDDTHYFVMTAKKQSLLDKGVILHDYADTELLLSRENV 280 290 300 310 320 330 340 350 360 370 380 390 pF1KA0 DQEALLSYAREAADFSTQQQLPSLDFAINHYGQPDVAMFDFTCMYASENAALVREQNGHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DQEALLSYAREAADFSTQQQLPSLDFAINHYGQPDVAMFDFTCMYASENAALVREQNGHQ 340 350 360 370 380 390 400 410 420 430 440 450 pF1KA0 LLVALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWSLGTSPLEVLAERESIYRLLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLVALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWSLGTSPLEVLAERESIYRLLPQ 400 410 420 430 440 450 460 470 480 490 500 510 pF1KA0 TTPENVSKNFSQYSIDPVTRYPNINVNFLRPSQVRHLYDTGETKDIHLEMESLVNSRTTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTPENVSKNFSQYSIDPVTRYPNINVNFLRPSQVRHLYDTGETKDIHLEMESLVNSRTTP 460 470 480 490 500 510 520 530 540 550 560 570 pF1KA0 KLTRNESVARSSKLLGWCQRQTDGYAGVNVTDLTMSWKSGLALCAIIHRYRPDLIDFDSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLTRNESVARSSKLLGWCQRQTDGYAGVNVTDLTMSWKSGLALCAIIHRYRPDLIDFDSL 520 530 540 550 560 570 580 590 600 610 620 630 pF1KA0 DEQNVEKNNQLAFDIAEKELGISPIMTGKEMASVGEPDKLSMVMYLTQFYEMFKDSLPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEQNVEKNNQLAFDIAEKELGISPIMTGKEMASVGEPDKLSMVMYLTQFYEMFKDSLPSS 580 590 600 610 620 630 640 650 660 670 680 690 pF1KA0 DTLDLNAEEKAVLIASTRSPISFLSKLGQTISRKRSPKDKKEKDLDGAGKRRKTSQSEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTLDLNAEEKAVLIASTRSPISFLSKLGQTISRKRSPKDKKEKDLDGAGKRRKTSQSEEE 640 650 660 670 680 690 700 710 720 730 740 pF1KA0 EAPRGHRGERPTLVSTLTDRRMDVAVGNQNKVKYMATQLLAKFEENAPAQSIGIRRQ--- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAPRGHRGERPTLVSTLTDRRMDVAVGNQNKVKYMATQLLAKFEENAPAQSIGIRRQLTQ 700 710 720 730 740 750 pF1KA0 ------------------------------------------------------------ XP_016 ERGASQPSCCLPGQVRPAPTPRWKQQREKECSRTCPKKVITLSPPPTPPPCRAHGGQQTY 760 770 780 790 800 810 pF1KA0 ------------------------------------------------------------ XP_016 RDLDADNRGKQSPHHERPEPEPPRRFFVDQWELSLSLRSSARPASPSSDSLRQKYIKMYT 820 830 840 850 860 870 750 760 770 pF1KA0 -----------------------------GSMKKEFPQNLGGSDTCYFCQKRVYVMERLS ::::::::::::::::::::::::::::::: XP_016 GGVSSLAEQIANQLQRKEQPKALLDKKELGSMKKEFPQNLGGSDTCYFCQKRVYVMERLS 880 890 900 910 920 930 780 790 800 810 820 830 pF1KA0 AEGKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEGKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSG 940 950 960 970 980 990 840 850 860 870 880 890 pF1KA0 KEAKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEAKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRL 1000 1010 1020 1030 1040 1050 900 910 920 930 940 950 pF1KA0 SLRQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLRQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDL 1060 1070 1080 1090 1100 1110 960 970 980 990 1000 1010 pF1KA0 GGVPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGVPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSE 1120 1130 1140 1150 1160 1170 1020 1030 1040 1050 1060 1070 pF1KA0 DQHWSDSPSDADRELRLPCPAEGEAELELRVSEDEEKLPASPKHQERGPSQATSPIRSPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DQHWSDSPSDADRELRLPCPAEGEAELELRVSEDEEKLPASPKHQERGPSQATSPIRSPQ 1180 1190 1200 1210 1220 1230 1080 1090 1100 1110 1120 1130 pF1KA0 ESALLFIPVHSPSTEGPQLPPVPAATQEKSPEERLFPEPLLPKEKPKADAPSDLKAVHSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESALLFIPVHSPSTEGPQLPPVPAATQEKSPEERLFPEPLLPKEKPKADAPSDLKAVHSP 1240 1250 1260 1270 1280 1290 1140 1150 1160 1170 1180 1190 pF1KA0 IRSQPVTLPEARTPVSPGSPQPRPPVAASTPPPSPLPICSQPQPSTEATVPSPTQSPIRF ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::: XP_016 IRSQPVTLPEARTPVSPGSPQPQPPVAASTPPPSPLPICSQPQPSTEATVPSPTQSPIRF 1300 1310 1320 1330 1340 1350 1200 1210 1220 1230 1240 1250 pF1KA0 QPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRRSDLVEEFWMKSAEIRRSLGLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRRSDLVEEFWMKSAEIRRSLGLTP 1360 1370 1380 1390 1400 1410 1260 1270 1280 1290 1300 1310 pF1KA0 VDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLLKPLSIPKRLGLPKPEGEPLSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLLKPLSIPKRLGLPKPEGEPLSLP 1420 1430 1440 1450 1460 1470 1320 1330 1340 1350 1360 1370 pF1KA0 TPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPP 1480 1490 1500 1510 1520 1530 1380 1390 1400 1410 1420 1430 pF1KA0 PPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPREPAQPPREEVRKSFVESVEEIPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPREPAQPPREEVRKSFVESVEEIPF 1540 1550 1560 1570 1580 1590 1440 1450 1460 1470 1480 1490 pF1KA0 ADDVEDTYDDKTEDSSLQEKFFTPPSCWPRPEKPRHPPLAKENGRLPALEGTLQPQKRGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADDVEDTYDDKTEDSSLQEKFFTPPSCWPRPEKPRHPPLAKENGRLPALEGTLQPQKRGL 1600 1610 1620 1630 1640 1650 1500 1510 1520 1530 1540 1550 pF1KA0 PLVSAEAKELAEERMRAREKSVKSQALRDAMARQLSRMQQMELASGAPRPRKASSAPSQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLVSAEAKELAEERMRAREKSVKSQALRDAMARQLSRMQQMELASGAPRPRKASSAPSQG 1660 1670 1680 1690 1700 1710 1560 1570 1580 1590 1600 1610 pF1KA0 KERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSGGPDGSFTSSEGSSGKSKKRSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSGGPDGSFTSSEGSSGKSKKRSSL 1720 1730 1740 1750 1760 1770 1620 1630 1640 1650 1660 1670 pF1KA0 FSPRRNKKEKKSKGEGRPPEKPSSNLLEEAAAKPKSLWKSVFSGYKKDKKKKADDKSCPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSPRRNKKEKKSKGEGRPPEKPSSNLLEEAAAKPKSLWKSVFSGYKKDKKKKADDKSCPS 1780 1790 1800 1810 1820 1830 1680 1690 1700 1710 1720 1730 pF1KA0 TPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLSSDDVLEKSSQKSRRE------- ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLSSDDVLEKSSQKSRRESIYVPHA 1840 1850 1860 1870 1880 1890 1740 1750 1760 1770 1780 pF1KA0 ----------PRTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQVEERQ :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAFRRSCASKPRTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQVEERQ 1900 1910 1920 1930 1940 1950 1790 1800 1810 1820 pF1KA0 RRLEERGVAVEKALRGEA-----------------GMGKKDDPKLMQEWFKLVQEKNAMV :::::::::::::::::: ::::::::::::::::::::::::: XP_016 RRLEERGVAVEKALRGEADYWGESYYSDLIDLHLGGMGKKDDPKLMQEWFKLVQEKNAMV 1960 1970 1980 1990 2000 2010 1830 1840 1850 1860 1870 1880 pF1KA0 RYESELMIFARELELEDRQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RYESELMIFARELELEDRQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRD 2020 2030 2040 2050 2060 2070 1890 1900 1910 pF1KA0 SLVALLEEQRLREREEDKDLEAAMLSKGFSLNWS :::::::::::::::::::::::::::::::: XP_016 SLVALLEEQRLREREEDKDLEAAMLSKGFSLNWS 2080 2090 2100 >-- initn: 817 init1: 817 opt: 817 Z-score: 329.3 bits: 74.5 E(85289): 1.3e-11 Smith-Waterman score: 817; 100.0% identity (100.0% similar) in 120 aa overlap (1-120:1-120) 10 20 30 40 50 60 pF1KA0 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN XP_016 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN 130 140 150 160 170 180 >>NP_001116203 (OMIM: 608882) protein-methionine sulfoxi (966 aa) initn: 6163 init1: 6163 opt: 6173 Z-score: 2389.1 bits: 454.5 E(85289): 2.5e-126 Smith-Waterman score: 6173; 97.6% identity (98.3% similar) in 963 aa overlap (1-959:1-963) 10 20 30 40 50 60 pF1KA0 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL 850 860 870 880 890 900 910 920 930 940 950 pF1KA0 RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSES----EMEEEGEEEEEEPRLPPS ::::::::::::::::::::::::::::::::: . : .: .. . .: ::. NP_001 RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASRDWVSPWLPRMVSNSWAQMIHPPQPPT 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KA0 DLGGVPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEES :: NP_001 VLGSQM >>XP_016884376 (OMIM: 608882) PREDICTED: protein-methion (965 aa) initn: 6170 init1: 6170 opt: 6170 Z-score: 2388.0 bits: 454.3 E(85289): 2.8e-126 Smith-Waterman score: 6170; 99.9% identity (100.0% similar) in 935 aa overlap (1-935:1-935) 10 20 30 40 50 60 pF1KA0 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGG ::::::::::::::::::::::::::::::::::. XP_016 RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSTKHRIGCLSSRRSFLAEMLDWKMRNG 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 VPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSEDQ XP_016 IILRH >>XP_011544444 (OMIM: 608882) PREDICTED: protein-methion (2175 aa) initn: 11048 init1: 5978 opt: 6057 Z-score: 2338.9 bits: 446.4 E(85289): 1.5e-123 Smith-Waterman score: 10618; 86.8% identity (86.8% similar) in 1950 aa overlap (226-1918:226-2175) 200 210 220 230 240 250 pF1KA0 ERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGKLAIAITANFINRNTT :::::::::::::::::::::::::::::: XP_011 ERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGKLAIAITANFINRNTT 200 210 220 230 240 250 260 270 280 290 300 310 pF1KA0 AEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFVMTAKKQSLLDKGVIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFVMTAKKQSLLDKGVIL 260 270 280 290 300 310 320 330 340 350 360 370 pF1KA0 HDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINHYGQPDVAMFDFTCMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINHYGQPDVAMFDFTCMY 320 330 340 350 360 370 380 390 400 410 420 430 pF1KA0 ASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWSLGTSPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWSLGTSPL 380 390 400 410 420 430 440 450 460 470 480 490 pF1KA0 EVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLRPSQVRHLYDTGETKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLRPSQVRHLYDTGETKD 440 450 460 470 480 490 500 510 520 530 540 550 pF1KA0 IHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNVTDLTMSWKSGLALCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNVTDLTMSWKSGLALCA 500 510 520 530 540 550 560 570 580 590 600 610 pF1KA0 IIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKEMASVGEPDKLSMVMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKEMASVGEPDKLSMVMY 560 570 580 590 600 610 620 630 640 650 660 670 pF1KA0 LTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQTISRKRSPKDKKEKDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQTISRKRSPKDKKEKDL 620 630 640 650 660 670 680 690 700 710 720 730 pF1KA0 DGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQNKVKYMATQLLAKFEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQNKVKYMATQLLAKFEE 680 690 700 710 720 730 740 pF1KA0 NAPAQSIGIRRQ------------------------------------------------ :::::::::::: XP_011 NAPAQSIGIRRQLTQERGASQPSCCLPGQVRPAPTPRWKQQREKECSRTCPKKVITLSPP 740 750 760 770 780 790 pF1KA0 ------------------------------------------------------------ XP_011 PTPPPCRAHGGQQTYRDLDADNRGKQSPHHERPEPEPPRRFFVDQWELSLSLRSSARPAS 800 810 820 830 840 850 750 760 pF1KA0 --------------------------------------------GSMKKEFPQNLGGSDT :::::::::::::::: XP_011 PSSDSLRQKYIKMYTGGVSSLAEQIANQLQRKEQPKALLDKKELGSMKKEFPQNLGGSDT 860 870 880 890 900 910 770 780 790 800 810 820 pF1KA0 CYFCQKRVYVMERLSAEGKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CYFCQKRVYVMERLSAEGKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLS 920 930 940 950 960 970 830 840 850 860 870 880 pF1KA0 GYAQRKRPAVAPLSGKEAKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GYAQRKRPAVAPLSGKEAKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKR 980 990 1000 1010 1020 1030 890 900 910 920 930 940 pF1KA0 LRGTPERIELENYRLSLRQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRGTPERIELENYRLSLRQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEE 1040 1050 1060 1070 1080 1090 950 960 970 980 990 1000 pF1KA0 GEEEEEEPRLPPSDLGGVPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GEEEEEEPRLPPSDLGGVPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEE 1100 1110 1120 1130 1140 1150 1010 pF1KA0 EEEEDYDEEEEESSE--------------------------------------------- ::::::::::::::: XP_011 EEEEDYDEEEEESSEAGNQRLQQVMHAADPLEIQADVHWTHIREREEEERMAPASESSAS 1160 1170 1180 1190 1200 1210 pF1KA0 ------------------------------------------------------------ XP_011 GVPDLPSIRHAAVQAWLETVSGAPLDENDLEEDVDSEPAEIEGEAAEDGDPGDTGAELDD 1220 1230 1240 1250 1260 1270 1020 1030 1040 1050 1060 1070 pF1KA0 DQHWSDSPSDADRELRLPCPAEGEAELELRVSEDEEKLPASPKHQERGPSQATSPIRSPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQHWSDSPSDADRELRLPCPAEGEAELELRVSEDEEKLPASPKHQERGPSQATSPIRSPQ 1280 1290 1300 1310 1320 1330 1080 1090 1100 1110 1120 1130 pF1KA0 ESALLFIPVHSPSTEGPQLPPVPAATQEKSPEERLFPEPLLPKEKPKADAPSDLKAVHSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESALLFIPVHSPSTEGPQLPPVPAATQEKSPEERLFPEPLLPKEKPKADAPSDLKAVHSP 1340 1350 1360 1370 1380 1390 1140 1150 1160 1170 1180 1190 pF1KA0 IRSQPVTLPEARTPVSPGSPQPRPPVAASTPPPSPLPICSQPQPSTEATVPSPTQSPIRF ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::: XP_011 IRSQPVTLPEARTPVSPGSPQPQPPVAASTPPPSPLPICSQPQPSTEATVPSPTQSPIRF 1400 1410 1420 1430 1440 1450 1200 1210 1220 1230 1240 1250 pF1KA0 QPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRRSDLVEEFWMKSAEIRRSLGLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRRSDLVEEFWMKSAEIRRSLGLTP 1460 1470 1480 1490 1500 1510 1260 1270 1280 1290 1300 1310 pF1KA0 VDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLLKPLSIPKRLGLPKPEGEPLSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLLKPLSIPKRLGLPKPEGEPLSLP 1520 1530 1540 1550 1560 1570 1320 1330 1340 1350 1360 1370 pF1KA0 TPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPP 1580 1590 1600 1610 1620 1630 1380 1390 1400 1410 1420 1430 pF1KA0 PPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPREPAQPPREEVRKSFVESVEEIPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPREPAQPPREEVRKSFVESVEEIPF 1640 1650 1660 1670 1680 1690 1440 1450 1460 1470 1480 1490 pF1KA0 ADDVEDTYDDKTEDSSLQEKFFTPPSCWPRPEKPRHPPLAKENGRLPALEGTLQPQKRGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADDVEDTYDDKTEDSSLQEKFFTPPSCWPRPEKPRHPPLAKENGRLPALEGTLQPQKRGL 1700 1710 1720 1730 1740 1750 1500 1510 1520 1530 1540 1550 pF1KA0 PLVSAEAKELAEERMRAREKSVKSQALRDAMARQLSRMQQMELASGAPRPRKASSAPSQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLVSAEAKELAEERMRAREKSVKSQALRDAMARQLSRMQQMELASGAPRPRKASSAPSQG 1760 1770 1780 1790 1800 1810 1560 1570 1580 1590 1600 1610 pF1KA0 KERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSGGPDGSFTSSEGSSGKSKKRSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSGGPDGSFTSSEGSSGKSKKRSSL 1820 1830 1840 1850 1860 1870 1620 1630 1640 1650 1660 1670 pF1KA0 FSPRRNKKEKKSKGEGRPPEKPSSNLLEEAAAKPKSLWKSVFSGYKKDKKKKADDKSCPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSPRRNKKEKKSKGEGRPPEKPSSNLLEEAAAKPKSLWKSVFSGYKKDKKKKADDKSCPS 1880 1890 1900 1910 1920 1930 1680 1690 1700 1710 1720 1730 pF1KA0 TPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLSSDDVLEKSSQKSRREPRTYTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLSSDDVLEKSSQKSRREPRTYTEE 1940 1950 1960 1970 1980 1990 1740 1750 1760 1770 1780 1790 pF1KA0 ELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQVEERQRRLEERGVAVEKALRGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQVEERQRRLEERGVAVEKALRGE 2000 2010 2020 2030 2040 2050 1800 1810 1820 1830 1840 1850 pF1KA0 AGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELEDRQSRLQQELRERMAVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELEDRQSRLQQELRERMAVED 2060 2070 2080 2090 2100 2110 1860 1870 1880 1890 1900 1910 pF1KA0 HLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLREREEDKDLEAAMLSKGFSLNWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLREREEDKDLEAAMLSKGFSLNWS 2120 2130 2140 2150 2160 2170 >-- initn: 1534 init1: 1534 opt: 1534 Z-score: 604.1 bits: 125.3 E(85289): 6.6e-27 Smith-Waterman score: 1534; 100.0% identity (100.0% similar) in 225 aa overlap (1-225:1-225) 10 20 30 40 50 60 pF1KA0 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK ::::::::::::::::::::::::::::::::::::::::::::: XP_011 VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV XP_011 LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV 250 260 270 280 290 300 1918 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 10:22:16 2016 done: Thu Nov 3 10:22:19 2016 Total Scan time: 24.880 Total Display time: 1.160 Function used was FASTA [36.3.4 Apr, 2011]