FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0864, 1038 aa 1>>>pF1KA0864 1038 - 1038 aa - 1038 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.1556+/-0.000433; mu= -15.6815+/- 0.027 mean_var=425.8698+/-86.928, 0's: 0 Z-trim(122.5): 22 B-trim: 0 in 0/59 Lambda= 0.062149 statistics sampled from 40712 (40737) to 40712 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.762), E-opt: 0.2 (0.478), width: 16 Scan time: 13.910 The best scores are: opt bits E(85289) NP_055949 (OMIM: 612935) myosin phosphatase Rho-in (1038) 6847 629.1 3.9e-179 NP_958431 (OMIM: 612935) myosin phosphatase Rho-in (1025) 6717 617.4 1.3e-175 XP_005256620 (OMIM: 612935) PREDICTED: myosin phos (2339) 4996 463.3 7e-129 XP_011522068 (OMIM: 612935) PREDICTED: myosin phos (1188) 4857 450.7 2.3e-125 XP_011522069 (OMIM: 612935) PREDICTED: myosin phos (1175) 4727 439.0 7.2e-122 XP_005256621 (OMIM: 612935) PREDICTED: myosin phos (1032) 4302 400.9 1.9e-110 XP_016879882 (OMIM: 612935) PREDICTED: myosin phos (1135) 3787 354.7 1.7e-96 XP_011522067 (OMIM: 612935) PREDICTED: myosin phos (2404) 3006 284.9 3.7e-75 XP_011522066 (OMIM: 612935) PREDICTED: myosin phos (2417) 3006 284.9 3.7e-75 XP_011522064 (OMIM: 612935) PREDICTED: myosin phos (2444) 3006 284.9 3.7e-75 XP_011522063 (OMIM: 612935) PREDICTED: myosin phos (2457) 3006 284.9 3.7e-75 XP_011522065 (OMIM: 612935) PREDICTED: myosin phos (2419) 2435 233.7 9.5e-60 NP_008963 (OMIM: 609761,609823) TRIO and F-actin-b ( 652) 591 68.0 1.9e-10 NP_001034230 (OMIM: 609761,609823) TRIO and F-acti (2365) 591 68.4 5.5e-10 NP_619538 (OMIM: 609761,609823) TRIO and F-actin-b ( 431) 567 65.8 6.1e-10 >>NP_055949 (OMIM: 612935) myosin phosphatase Rho-intera (1038 aa) initn: 6847 init1: 6847 opt: 6847 Z-score: 3337.0 bits: 629.1 E(85289): 3.9e-179 Smith-Waterman score: 6847; 100.0% identity (100.0% similar) in 1038 aa overlap (1-1038:1-1038) 10 20 30 40 50 60 pF1KA0 MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 NPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQKFSLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 NPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQKFSLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 ILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVAVTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVAVTSS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 SSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSLREPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSLREPG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTPNHRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTPNHRR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 SQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDAS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 ASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYYRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYYRD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 HVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 HVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 KTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 ATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVH 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 LSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 QATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHR 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 EEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 EEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 LEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAY 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 ELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDIS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 RLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSLKEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSLKEG 970 980 990 1000 1010 1020 1030 pF1KA0 LTVQERLKLFESRDLKKD :::::::::::::::::: NP_055 LTVQERLKLFESRDLKKD 1030 >>NP_958431 (OMIM: 612935) myosin phosphatase Rho-intera (1025 aa) initn: 6831 init1: 6717 opt: 6717 Z-score: 3274.1 bits: 617.4 E(85289): 1.3e-175 Smith-Waterman score: 6717; 99.5% identity (99.8% similar) in 1022 aa overlap (1-1022:1-1022) 10 20 30 40 50 60 pF1KA0 MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 NPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQKFSLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 NPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQKFSLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 ILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVAVTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 ILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVAVTSS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 SSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSLREPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 SSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSLREPG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTPNHRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 LESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTPNHRR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 SQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 SQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDAS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 ASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYYRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 ASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYYRD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 SVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 HVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 HVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 KTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 KTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 ATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 ATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVH 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 LSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 LSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 QATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 QATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHR 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 EEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 EEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 LEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 LEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAY 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 ELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 ELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDIS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 RLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSLKEG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::. : NP_958 RLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSVIEQ 970 980 990 1000 1010 1020 1030 pF1KA0 LTVQERLKLFESRDLKKD .. NP_958 VSWDT >>XP_005256620 (OMIM: 612935) PREDICTED: myosin phosphat (2339 aa) initn: 4877 init1: 4877 opt: 4996 Z-score: 2434.8 bits: 463.3 E(85289): 7e-129 Smith-Waterman score: 4996; 79.5% identity (89.2% similar) in 979 aa overlap (1-968:33-1002) 10 20 30 pF1KA0 MSAAKENPCRKFQANIFNKSKCQNCFKPRE :::::::::::::::::::::::::::::: XP_005 RGRAEPLARRERQAGQACAAAAAAVAAAPTMSAAKENPCRKFQANIFNKSKCQNCFKPRE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 SHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 TTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPR 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA0 TNKQNQKKKRKVEPPTPQEPGPAKVAVTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TNKQNQKKKRKVEPPTPQEPGPAKVAVTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRT 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA0 KDQPDGSSLSPAQSPSQSQPPAASSLREPGLESKEEESAMSSDRMDCGRKVRVESGYFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KDQPDGSSLSPAQSPSQSQPPAASSLREPGLESKEEESAMSSDRMDCGRKVRVESGYFSL 250 260 270 280 290 300 280 290 300 310 320 330 pF1KA0 EKTKQDLKAEEQQLPPPLSPPSPSTPNHRRSQVIEKFEALDIEKAEHMETNAVGPSPSSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKTKQDLKAEEQQLPPPLSPPSPSTPNHRRSQVIEKFEALDIEKAEHMETNAVGPSPSSD 310 320 330 340 350 360 340 350 360 370 380 390 pF1KA0 TRQGRSEKRAFPRKRDFTNEAPPAPLPDASASPLSPHRRAKSLDRRSTEPSVTPDLLNFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TRQGRSEKRAFPRKRDFTNEAPPAPLPDASASPLSPHRRAKSLDRRSTEPSVTPDLLNFK 370 380 390 400 410 420 400 410 420 430 440 450 pF1KA0 KGWLTKQYEDGQWKKHWFVLADQSLRYYRDSVAEEAADLDGEIDLSACYDVTEYPVQRNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KGWLTKQYEDGQWKKHWFVLADQSLRYYRDSVAEEAADLDGEIDLSACYDVTEYPVQRNY 430 440 450 460 470 480 460 470 480 490 500 510 pF1KA0 GFQIHTKEGEFTLSAMTSGIRRNWIQTIMKHVHPTTAPDVTSSLPEEKNKSSCSFETCPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GFQIHTKEGEFTLSAMTSGIRRNWIQTIMKHVHPTTAPDVTSSLPEEKNKSSCSFETCPR 490 500 510 520 530 540 520 530 540 550 560 570 pF1KA0 PTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHE 550 560 570 580 590 600 580 590 600 610 620 630 pF1KA0 PLRPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PLRPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTH 610 620 630 640 650 660 640 650 660 670 680 690 pF1KA0 NVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEA 670 680 690 700 710 720 700 710 720 730 740 750 pF1KA0 SDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQREL :::::::::::::::::::::::::::::::. :: .... .... : :: XP_005 SDLLEQNRLLQDQLRVALGREQSAREGYVLQTEV----AASPSGAWQRLHRVNQDLQSEL 730 740 750 760 770 760 770 780 790 800 810 pF1KA0 EKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYL : . ....:.... . . :.. :.. : :. .: ....:.. ... :...: : XP_005 EA-QCQRQELITHQIQTLKRSYGEAKDTIRHH-EAEI-RSLQARLSNAAAEL-AIKEQAL 780 790 800 810 820 830 820 830 840 850 860 pF1KA0 EELQS-VQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQ----RENQELNA--HNQ .:.. ..:: . :: .. .: :.. :.: .: :.. . ...::: . .: XP_005 AKLKGDLKREQGRVREQLEERQHSEAALSSQLRASEQKLKSAEALLLEKTQELRGLETQQ 840 850 860 870 880 890 870 880 890 900 910 920 pF1KA0 ELNNRLAAEITRLRTL---LTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEI :. :. ::. :. . :. .. : . : . :.::. :.: : : :.. XP_005 ALQRDRQKEVQRLQERIADLSQQLGASEQAQRLMEEKLQRNYELLLESCEKEKQALLQNL 900 910 920 930 940 950 930 940 950 960 970 pF1KA0 SSLKDELQTALRDK-KYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALGEKSPD . ..:. .: .:. . ... . . : : ... .. .:.:::.: XP_005 KEVEDK-ASAYEDQLQGQAQQVETLQKEKLSATFEGSEQVHQLEEQLEAREASVRRLAEH 960 970 980 990 1000 1010 980 990 1000 1010 1020 1030 pF1KA0 SATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSLKEGLTVQERLKLFESRDLKKD XP_005 VQSLCDERDLLRQRFQELTERVATSDEDVAELREKLRRREADNQSLEHSYQRVSSQLQSM 1020 1030 1040 1050 1060 1070 >-- initn: 2029 init1: 1999 opt: 2011 Z-score: 988.4 bits: 195.7 E(85289): 2.6e-48 Smith-Waterman score: 2011; 73.9% identity (82.9% similar) in 479 aa overlap (580-1038:1872-2339) 550 560 570 580 590 600 pF1KA0 PIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDATDGPGTED .: : .. . :: . ...:::. ..: XP_005 QCLEDAESKHSMSMFTLRGRYEEEIRCVVEQLTRTESTLQAERSRVLSQLDAS----VRD 1850 1860 1870 1880 1890 610 620 630 640 650 pF1KA0 AALRMEVDRSPGLPMSDLKTH-NVHVEIEQRWHQVETTPLREE--------------KQV :....: : .. :. . ...:. : :. : :.:. .: XP_005 ---RQDMERHHGEQIQTLEDRFQLKVRELQTIHEEELRTLQEHYSQSLRCLQDTLCLHQG 1900 1910 1920 1930 1940 1950 660 670 680 690 700 pF1KA0 PIAPVHLSSEDGGDRLSTHE---LTSLLEK--ELEQSQKEASDLLEQNRLLQDQLRVALG : : : . . . . : .:.: :. ::: .. . : .. : : .: XP_005 P-HPKALPAPAPNWQATQGEADSMTGLRERIQELEAQMDVMREELGHKDLEGD---AATL 1960 1970 1980 1990 2000 2010 710 720 730 740 750 760 pF1KA0 REQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATI ::. :. :.:::::::::::::::::::::::::::::::::::::::::::::::: XP_005 REKYQRDLESLKATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATI 2020 2030 2040 2050 2060 2070 770 780 790 800 810 820 pF1KA0 SAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQ 2080 2090 2100 2110 2120 2130 830 840 850 860 870 880 pF1KA0 KCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEAT 2140 2150 2160 2170 2180 2190 890 900 910 920 930 940 pF1KA0 GSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELS 2200 2210 2220 2230 2240 2250 950 960 970 980 990 1000 pF1KA0 IAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQL 2260 2270 2280 2290 2300 2310 1010 1020 1030 pF1KA0 RNIRSKSLKEGLTVQERLKLFESRDLKKD ::::::::::::::::::::::::::::: XP_005 RNIRSKSLKEGLTVQERLKLFESRDLKKD 2320 2330 >>XP_011522068 (OMIM: 612935) PREDICTED: myosin phosphat (1188 aa) initn: 4821 init1: 4821 opt: 4857 Z-score: 2371.8 bits: 450.7 E(85289): 2.3e-125 Smith-Waterman score: 5986; 89.0% identity (89.0% similar) in 1070 aa overlap (87-1038:119-1188) 60 70 80 90 100 110 pF1KA0 TDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQK :::::::::::::::::::::::::::::: XP_011 TDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQK 90 100 110 120 130 140 120 130 140 150 160 170 pF1KA0 FSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVA 150 160 170 180 190 200 180 190 200 210 220 230 pF1KA0 VTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSL 210 220 230 240 250 260 240 250 260 270 280 290 pF1KA0 REPGLESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REPGLESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTP 270 280 290 300 310 320 pF1KA0 NHR--------------------------------------------------------- ::: XP_011 NHRYSCPESPSQELGGPLPSPGPRLPHQMVCSISLSSLDVASQPPAYVDSGSTRGRGTER 330 340 350 360 370 380 pF1KA0 ------------------------------------------------------------ XP_011 LGSAFAFKASRQYATLADVPKAIRISHREAFQVERRRLERRTRARSPGREEVARLFGNER 390 400 410 420 430 440 300 310 320 330 340 350 pF1KA0 -RSQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRSQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPD 450 460 470 480 490 500 360 370 380 390 400 410 pF1KA0 ASASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYY 510 520 530 540 550 560 420 430 440 450 460 470 pF1KA0 RDSVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDSVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTI 570 580 590 600 610 620 480 490 500 510 520 530 pF1KA0 MKHVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKHVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREG 630 640 650 660 670 680 540 550 560 570 580 590 pF1KA0 RSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGM 690 700 710 720 730 740 600 610 620 630 640 650 pF1KA0 LDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAP 750 760 770 780 790 800 660 670 680 690 700 710 pF1KA0 VHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGY 810 820 830 840 850 860 720 730 740 750 760 770 pF1KA0 VLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNA 870 880 890 900 910 920 780 790 800 810 820 830 pF1KA0 HREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLA 930 940 950 960 970 980 840 850 860 870 880 890 pF1KA0 QALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD 990 1000 1010 1020 1030 1040 900 910 920 930 940 950 pF1KA0 AYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCD 1050 1060 1070 1080 1090 1100 960 970 980 990 1000 1010 pF1KA0 ISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSLK 1110 1120 1130 1140 1150 1160 1020 1030 pF1KA0 EGLTVQERLKLFESRDLKKD :::::::::::::::::::: XP_011 EGLTVQERLKLFESRDLKKD 1170 1180 >-- initn: 615 init1: 615 opt: 615 Z-score: 316.2 bits: 70.3 E(85289): 7.1e-11 Smith-Waterman score: 615; 100.0% identity (100.0% similar) in 86 aa overlap (1-86:33-118) 10 20 30 pF1KA0 MSAAKENPCRKFQANIFNKSKCQNCFKPRE :::::::::::::::::::::::::::::: XP_011 RGRAEPLARRERQAGQACAAAAAAVAAAPTMSAAKENPCRKFQANIFNKSKCQNCFKPRE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 SHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 TTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPR XP_011 TTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPR 130 140 150 160 170 180 >>XP_011522069 (OMIM: 612935) PREDICTED: myosin phosphat (1175 aa) initn: 6776 init1: 4691 opt: 4727 Z-score: 2308.9 bits: 439.0 E(85289): 7.2e-122 Smith-Waterman score: 5856; 88.3% identity (88.6% similar) in 1054 aa overlap (87-1022:119-1172) 60 70 80 90 100 110 pF1KA0 TDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQK :::::::::::::::::::::::::::::: XP_011 TDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQK 90 100 110 120 130 140 120 130 140 150 160 170 pF1KA0 FSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVA 150 160 170 180 190 200 180 190 200 210 220 230 pF1KA0 VTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSL 210 220 230 240 250 260 240 250 260 270 280 290 pF1KA0 REPGLESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REPGLESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTP 270 280 290 300 310 320 pF1KA0 NHR--------------------------------------------------------- ::: XP_011 NHRYSCPESPSQELGGPLPSPGPRLPHQMVCSISLSSLDVASQPPAYVDSGSTRGRGTER 330 340 350 360 370 380 pF1KA0 ------------------------------------------------------------ XP_011 LGSAFAFKASRQYATLADVPKAIRISHREAFQVERRRLERRTRARSPGREEVARLFGNER 390 400 410 420 430 440 300 310 320 330 340 350 pF1KA0 -RSQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRSQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPD 450 460 470 480 490 500 360 370 380 390 400 410 pF1KA0 ASASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYY 510 520 530 540 550 560 420 430 440 450 460 470 pF1KA0 RDSVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDSVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTI 570 580 590 600 610 620 480 490 500 510 520 530 pF1KA0 MKHVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKHVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREG 630 640 650 660 670 680 540 550 560 570 580 590 pF1KA0 RSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGM 690 700 710 720 730 740 600 610 620 630 640 650 pF1KA0 LDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAP 750 760 770 780 790 800 660 670 680 690 700 710 pF1KA0 VHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGY 810 820 830 840 850 860 720 730 740 750 760 770 pF1KA0 VLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNA 870 880 890 900 910 920 780 790 800 810 820 830 pF1KA0 HREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLA 930 940 950 960 970 980 840 850 860 870 880 890 pF1KA0 QALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD 990 1000 1010 1020 1030 1040 900 910 920 930 940 950 pF1KA0 AYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCD 1050 1060 1070 1080 1090 1100 960 970 980 990 1000 1010 pF1KA0 ISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSLK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. XP_011 ISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSVI 1110 1120 1130 1140 1150 1160 1020 1030 pF1KA0 EGLTVQERLKLFESRDLKKD : .. XP_011 EQVSWDT 1170 >-- initn: 615 init1: 615 opt: 615 Z-score: 316.3 bits: 70.3 E(85289): 7e-11 Smith-Waterman score: 615; 100.0% identity (100.0% similar) in 86 aa overlap (1-86:33-118) 10 20 30 pF1KA0 MSAAKENPCRKFQANIFNKSKCQNCFKPRE :::::::::::::::::::::::::::::: XP_011 RGRAEPLARRERQAGQACAAAAAAVAAAPTMSAAKENPCRKFQANIFNKSKCQNCFKPRE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 SHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 TTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPR XP_011 TTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPR 130 140 150 160 170 180 >>XP_005256621 (OMIM: 612935) PREDICTED: myosin phosphat (1032 aa) initn: 6578 init1: 4261 opt: 4302 Z-score: 2103.8 bits: 400.9 E(85289): 1.9e-110 Smith-Waterman score: 6506; 96.3% identity (96.3% similar) in 1038 aa overlap (1-1038:33-1032) 10 20 30 pF1KA0 MSAAKENPCRKFQANIFNKSKCQNCFKPRE :::::::::::::::::::::::::::::: XP_005 RGRAEPLARRERQAGQACAAAAAAVAAAPTMSAAKENPCRKFQANIFNKSKCQNCFKPRE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 SHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 TTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPR 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA0 TNKQNQKKKRKVEPPTPQEPGPAKVAVTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TNKQNQKKKRKVEPPTPQEPGPAKVAVTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRT 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA0 KDQPDGSSLSPAQSPSQSQPPAASSLREPGLESKEEESAMSSDRMDCGRKVRVESGYFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KDQPDGSSLSPAQSPSQSQPPAASSLREPGLESKEEESAMSSDRMDCGRKVRVESGYFSL 250 260 270 280 290 300 280 290 300 310 320 330 pF1KA0 EKTKQDLKAEEQQLPPPLSPPSPSTPNHRRSQVIEKFEALDIEKAEHMETNAVGPSPSSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKTKQDLKAEEQQLPPPLSPPSPSTPNHRRSQVIEKFEALDIEKAEHMETNAVGPSPSSD 310 320 330 340 350 360 340 350 360 370 380 390 pF1KA0 TRQGRSEKRAFPRKRDFTNEAPPAPLPDASASPLSPHRRAKSLDRRSTEPSVTPDLLNFK ::::::::::::::: ::::::: XP_005 TRQGRSEKRAFPRKR--------------------------------------PDLLNFK 370 380 400 410 420 430 440 450 pF1KA0 KGWLTKQYEDGQWKKHWFVLADQSLRYYRDSVAEEAADLDGEIDLSACYDVTEYPVQRNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KGWLTKQYEDGQWKKHWFVLADQSLRYYRDSVAEEAADLDGEIDLSACYDVTEYPVQRNY 390 400 410 420 430 440 460 470 480 490 500 510 pF1KA0 GFQIHTKEGEFTLSAMTSGIRRNWIQTIMKHVHPTTAPDVTSSLPEEKNKSSCSFETCPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GFQIHTKEGEFTLSAMTSGIRRNWIQTIMKHVHPTTAPDVTSSLPEEKNKSSCSFETCPR 450 460 470 480 490 500 520 530 540 550 560 570 pF1KA0 PTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHE 510 520 530 540 550 560 580 590 600 610 620 630 pF1KA0 PLRPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PLRPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTH 570 580 590 600 610 620 640 650 660 670 680 690 pF1KA0 NVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEA 630 640 650 660 670 680 700 710 720 730 740 750 pF1KA0 SDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQREL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQREL 690 700 710 720 730 740 760 770 780 790 800 810 pF1KA0 EKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYL 750 760 770 780 790 800 820 830 840 850 860 870 pF1KA0 EELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLA 810 820 830 840 850 860 880 890 900 910 920 930 pF1KA0 AEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTA 870 880 890 900 910 920 940 950 960 970 980 990 pF1KA0 LRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMK 930 940 950 960 970 980 1000 1010 1020 1030 pF1KA0 SKSNPDFLKKDRSCVTRQLRNIRSKSLKEGLTVQERLKLFESRDLKKD :::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SKSNPDFLKKDRSCVTRQLRNIRSKSLKEGLTVQERLKLFESRDLKKD 990 1000 1010 1020 1030 >>XP_016879882 (OMIM: 612935) PREDICTED: myosin phosphat (1135 aa) initn: 4429 init1: 3738 opt: 3787 Z-score: 1853.6 bits: 354.7 E(85289): 1.7e-96 Smith-Waterman score: 5516; 84.5% identity (84.8% similar) in 1054 aa overlap (87-1022:119-1132) 60 70 80 90 100 110 pF1KA0 TDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQK :::::::::::::::::::::::::::::: XP_016 TDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQK 90 100 110 120 130 140 120 130 140 150 160 170 pF1KA0 FSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVA 150 160 170 180 190 200 180 190 200 210 220 230 pF1KA0 VTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSL 210 220 230 240 250 260 240 250 260 270 280 290 pF1KA0 REPGLESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REPGLESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTP 270 280 290 300 310 320 pF1KA0 NHR--------------------------------------------------------- ::: XP_016 NHRYSCPESPSQELGGPLPSPGPRLPHQMVCSISLSSLDVASQPPAYVDSGSTRGRGTER 330 340 350 360 370 380 pF1KA0 ------------------------------------------------------------ XP_016 LGSAFAFKASRQYATLADVPKAIRISHREAFQVERRRLERRTRARSPGREEVARLFGNER 390 400 410 420 430 440 300 310 320 330 340 350 pF1KA0 -RSQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRSQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPD 450 460 470 480 490 500 360 370 380 390 400 410 pF1KA0 ASASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYY 510 520 530 540 550 560 420 430 440 450 460 470 pF1KA0 RDSVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDSVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTI 570 580 590 600 610 620 480 490 500 510 520 530 pF1KA0 MKHVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKHVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREG 630 640 650 660 670 680 540 550 560 570 580 590 pF1KA0 RSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGM 690 700 710 720 730 740 600 610 620 630 640 650 pF1KA0 LDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAP 750 760 770 780 790 800 660 670 680 690 700 710 pF1KA0 VHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGY 810 820 830 840 850 860 720 730 740 750 760 770 pF1KA0 VLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNA 870 880 890 900 910 920 780 790 800 810 820 830 pF1KA0 HREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLA 930 940 950 960 970 980 840 850 860 870 880 890 pF1KA0 QALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD ::::::::::::::::::::::::: XP_016 QALEAERQALRQCQRENQELNAHNQ----------------------------------- 990 1000 1010 900 910 920 930 940 950 pF1KA0 AYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCD ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 -----VLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCD 1020 1030 1040 1050 1060 960 970 980 990 1000 1010 pF1KA0 ISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSLK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. XP_016 ISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSVI 1070 1080 1090 1100 1110 1120 1020 1030 pF1KA0 EGLTVQERLKLFESRDLKKD : .. XP_016 EQVSWDT 1130 >-- initn: 615 init1: 615 opt: 615 Z-score: 316.5 bits: 70.3 E(85289): 6.8e-11 Smith-Waterman score: 615; 100.0% identity (100.0% similar) in 86 aa overlap (1-86:33-118) 10 20 30 pF1KA0 MSAAKENPCRKFQANIFNKSKCQNCFKPRE :::::::::::::::::::::::::::::: XP_016 RGRAEPLARRERQAGQACAAAAAAVAAAPTMSAAKENPCRKFQANIFNKSKCQNCFKPRE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 SHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 TTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPR XP_016 TTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPR 130 140 150 160 170 180 >>XP_011522067 (OMIM: 612935) PREDICTED: myosin phosphat (2404 aa) initn: 3630 init1: 2851 opt: 3006 Z-score: 1470.4 bits: 284.9 E(85289): 3.7e-75 Smith-Waterman score: 4135; 68.4% identity (77.8% similar) in 1011 aa overlap (87-968:119-1120) 60 70 80 90 100 110 pF1KA0 TDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQK :::::::::::::::::::::::::::::: XP_011 TDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQK 90 100 110 120 130 140 120 130 140 150 160 170 pF1KA0 FSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVA 150 160 170 180 190 200 180 190 200 210 220 230 pF1KA0 VTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSL 210 220 230 240 250 260 240 250 260 270 280 290 pF1KA0 REPGLESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REPGLESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTP 270 280 290 300 310 320 pF1KA0 NHR--------------------------------------------------------- ::: XP_011 NHRYSCPESPSQELGGPLPSPGPRLPHQMVCSISLSSLDVASQPPAYVDSGSTRGRGTER 330 340 350 360 370 380 pF1KA0 ------------------------------------------------------------ XP_011 LGSAFAFKASRQYATLADVPKAIRISHREAFQVERRRLERRTRARSPGREEVARLFGNER 390 400 410 420 430 440 300 310 320 330 340 350 pF1KA0 -RSQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRSQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPD 450 460 470 480 490 500 360 370 380 390 400 410 pF1KA0 ASASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYY 510 520 530 540 550 560 420 430 440 450 460 470 pF1KA0 RDSVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDSVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTI 570 580 590 600 610 620 480 490 500 510 520 530 pF1KA0 MKHVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKHVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREG 630 640 650 660 670 680 540 550 560 570 580 590 pF1KA0 RSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGM 690 700 710 720 730 740 600 610 620 630 640 650 pF1KA0 LDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAP 750 760 770 780 790 800 660 670 680 690 700 710 pF1KA0 VHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGY 810 820 830 840 850 860 720 730 740 750 760 770 pF1KA0 VLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNA :::. :: .... .... : ::: . ....:.... . . :.. XP_011 VLQTEV----AASPSGAWQRLHRVNQDLQSELEA-QCQRQELITHQIQTLKRSYGEAKDT 870 880 890 900 910 920 780 790 800 810 820 830 pF1KA0 HREEMERELEKSQRSQISSVNSDVEALRRQYLEELQS-VQRELEVLSEQYSQKCLENAHL :.. : :. .: ....:.. ... :...: : .:.. ..:: . :: .. .: : XP_011 IRHH-EAEI-RSLQARLSNAAAEL-AIKEQALAKLKGDLKREQGRVREQLEERQHSEAAL 930 940 950 960 970 980 840 850 860 870 880 pF1KA0 AQALEAERQALRQCQ----RENQELNA--HNQELNNRLAAEITRLRTL---LTGDGGGEA .. :.: .: :.. . ...::: . .: :. :. ::. :. . :. XP_011 SSQLRASEQKLKSAEALLLEKTQELRGLETQQALQRDRQKEVQRLQERIADLSQQLGASE 990 1000 1010 1020 1030 1040 890 900 910 920 930 940 pF1KA0 TGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDK-KYASDKYKDIYTE .. : . : . :.::. :.: : : :... ..:. .: .:. . ... . . : XP_011 QAQRLMEEKLQRNYELLLESCEKEKQALLQNLKEVEDK-ASAYEDQLQGQAQQVETLQKE 1050 1060 1070 1080 1090 950 960 970 980 990 1000 pF1KA0 LSIAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTR : ... .. .:.:::.: XP_011 KLSATFEGSEQVHQLEEQLEAREASVRRLAEHVQSLCDERDLLRQRFQELTERVATSDED 1100 1110 1120 1130 1140 1150 >-- initn: 1637 init1: 916 opt: 941 Z-score: 469.7 bits: 99.7 E(85289): 2e-19 Smith-Waterman score: 1541; 63.3% identity (73.2% similar) in 463 aa overlap (580-1022:1990-2401) 550 560 570 580 590 600 pF1KA0 PIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDATDGPGTED .: : .. . :: . ...:::. ..: XP_011 QCLEDAESKHSMSMFTLRGRYEEEIRCVVEQLTRTESTLQAERSRVLSQLDAS----VRD 1960 1970 1980 1990 2000 2010 610 620 630 640 650 pF1KA0 AALRMEVDRSPGLPMSDLKTH-NVHVEIEQRWHQVETTPLREE--------------KQV :....: : .. :. . ...:. : :. : :.:. .: XP_011 ---RQDMERHHGEQIQTLEDRFQLKVRELQTIHEEELRTLQEHYSQSLRCLQDTLCLHQG 2020 2030 2040 2050 2060 2070 660 670 680 690 700 pF1KA0 PIAPVHLSSEDGGDRLSTHE---LTSLLEK--ELEQSQKEASDLLEQNRLLQDQLRVALG : : : . . . . : .:.: :. ::: .. . : .. : : .: XP_011 P-HPKALPAPAPNWQATQGEADSMTGLRERIQELEAQMDVMREELGHKDLEGD---AATL 2080 2090 2100 2110 2120 710 720 730 740 750 760 pF1KA0 REQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATI ::. :. :.:::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REKYQRDLESLKATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATI 2130 2140 2150 2160 2170 2180 770 780 790 800 810 820 pF1KA0 SAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQ 2190 2200 2210 2220 2230 2240 830 840 850 860 870 880 pF1KA0 KCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEAT :::::::::::::::::::::::::::::::::: XP_011 KCLENAHLAQALEAERQALRQCQRENQELNAHNQ-------------------------- 2250 2260 2270 2280 890 900 910 920 930 940 pF1KA0 GSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELS :::::::::::::::::::::::::::::::::::::::::::::: XP_011 --------------VLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELS 2290 2300 2310 2320 950 960 970 980 990 1000 pF1KA0 IAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQL 2330 2340 2350 2360 2370 2380 1010 1020 1030 pF1KA0 RNIRSKSLKEGLTVQERLKLFESRDLKKD :::::::. : .. XP_011 RNIRSKSVIEQVSWDT 2390 2400 >-- initn: 615 init1: 615 opt: 615 Z-score: 311.7 bits: 70.5 E(85289): 1.3e-10 Smith-Waterman score: 615; 100.0% identity (100.0% similar) in 86 aa overlap (1-86:33-118) 10 20 30 pF1KA0 MSAAKENPCRKFQANIFNKSKCQNCFKPRE :::::::::::::::::::::::::::::: XP_011 RGRAEPLARRERQAGQACAAAAAAVAAAPTMSAAKENPCRKFQANIFNKSKCQNCFKPRE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 SHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 TTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPR XP_011 TTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPR 130 140 150 160 170 180 >>XP_011522066 (OMIM: 612935) PREDICTED: myosin phosphat (2417 aa) initn: 3713 init1: 2851 opt: 3006 Z-score: 1470.3 bits: 284.9 E(85289): 3.7e-75 Smith-Waterman score: 4135; 68.4% identity (77.8% similar) in 1011 aa overlap (87-968:119-1120) 60 70 80 90 100 110 pF1KA0 TDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQK :::::::::::::::::::::::::::::: XP_011 TDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQK 90 100 110 120 130 140 120 130 140 150 160 170 pF1KA0 FSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVA 150 160 170 180 190 200 180 190 200 210 220 230 pF1KA0 VTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSL 210 220 230 240 250 260 240 250 260 270 280 290 pF1KA0 REPGLESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REPGLESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTP 270 280 290 300 310 320 pF1KA0 NHR--------------------------------------------------------- ::: XP_011 NHRYSCPESPSQELGGPLPSPGPRLPHQMVCSISLSSLDVASQPPAYVDSGSTRGRGTER 330 340 350 360 370 380 pF1KA0 ------------------------------------------------------------ XP_011 LGSAFAFKASRQYATLADVPKAIRISHREAFQVERRRLERRTRARSPGREEVARLFGNER 390 400 410 420 430 440 300 310 320 330 340 350 pF1KA0 -RSQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRSQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPD 450 460 470 480 490 500 360 370 380 390 400 410 pF1KA0 ASASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYY 510 520 530 540 550 560 420 430 440 450 460 470 pF1KA0 RDSVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDSVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTI 570 580 590 600 610 620 480 490 500 510 520 530 pF1KA0 MKHVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKHVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREG 630 640 650 660 670 680 540 550 560 570 580 590 pF1KA0 RSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGM 690 700 710 720 730 740 600 610 620 630 640 650 pF1KA0 LDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAP 750 760 770 780 790 800 660 670 680 690 700 710 pF1KA0 VHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGY 810 820 830 840 850 860 720 730 740 750 760 770 pF1KA0 VLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNA :::. :: .... .... : ::: . ....:.... . . :.. XP_011 VLQTEV----AASPSGAWQRLHRVNQDLQSELEA-QCQRQELITHQIQTLKRSYGEAKDT 870 880 890 900 910 920 780 790 800 810 820 830 pF1KA0 HREEMERELEKSQRSQISSVNSDVEALRRQYLEELQS-VQRELEVLSEQYSQKCLENAHL :.. : :. .: ....:.. ... :...: : .:.. ..:: . :: .. .: : XP_011 IRHH-EAEI-RSLQARLSNAAAEL-AIKEQALAKLKGDLKREQGRVREQLEERQHSEAAL 930 940 950 960 970 980 840 850 860 870 880 pF1KA0 AQALEAERQALRQCQ----RENQELNA--HNQELNNRLAAEITRLRTL---LTGDGGGEA .. :.: .: :.. . ...::: . .: :. :. ::. :. . :. XP_011 SSQLRASEQKLKSAEALLLEKTQELRGLETQQALQRDRQKEVQRLQERIADLSQQLGASE 990 1000 1010 1020 1030 1040 890 900 910 920 930 940 pF1KA0 TGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDK-KYASDKYKDIYTE .. : . : . :.::. :.: : : :... ..:. .: .:. . ... . . : XP_011 QAQRLMEEKLQRNYELLLESCEKEKQALLQNLKEVEDK-ASAYEDQLQGQAQQVETLQKE 1050 1060 1070 1080 1090 950 960 970 980 990 1000 pF1KA0 LSIAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTR : ... .. .:.:::.: XP_011 KLSATFEGSEQVHQLEEQLEAREASVRRLAEHVQSLCDERDLLRQRFQELTERVATSDED 1100 1110 1120 1130 1140 1150 >-- initn: 955 init1: 922 opt: 941 Z-score: 469.7 bits: 99.7 E(85289): 2e-19 Smith-Waterman score: 1671; 65.6% identity (74.5% similar) in 479 aa overlap (580-1038:1990-2417) 550 560 570 580 590 600 pF1KA0 PIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDATDGPGTED .: : .. . :: . ...:::. ..: XP_011 QCLEDAESKHSMSMFTLRGRYEEEIRCVVEQLTRTESTLQAERSRVLSQLDAS----VRD 1960 1970 1980 1990 2000 2010 610 620 630 640 650 pF1KA0 AALRMEVDRSPGLPMSDLKTH-NVHVEIEQRWHQVETTPLREE--------------KQV :....: : .. :. . ...:. : :. : :.:. .: XP_011 ---RQDMERHHGEQIQTLEDRFQLKVRELQTIHEEELRTLQEHYSQSLRCLQDTLCLHQG 2020 2030 2040 2050 2060 2070 660 670 680 690 700 pF1KA0 PIAPVHLSSEDGGDRLSTHE---LTSLLEK--ELEQSQKEASDLLEQNRLLQDQLRVALG : : : . . . . : .:.: :. ::: .. . : .. : : .: XP_011 P-HPKALPAPAPNWQATQGEADSMTGLRERIQELEAQMDVMREELGHKDLEGD---AATL 2080 2090 2100 2110 2120 710 720 730 740 750 760 pF1KA0 REQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATI ::. :. :.:::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REKYQRDLESLKATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATI 2130 2140 2150 2160 2170 2180 770 780 790 800 810 820 pF1KA0 SAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQ 2190 2200 2210 2220 2230 2240 830 840 850 860 870 880 pF1KA0 KCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEAT :::::::::::::::::::::::::::::::::: XP_011 KCLENAHLAQALEAERQALRQCQRENQELNAHNQ-------------------------- 2250 2260 2270 2280 890 900 910 920 930 940 pF1KA0 GSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELS :::::::::::::::::::::::::::::::::::::::::::::: XP_011 --------------VLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELS 2290 2300 2310 2320 950 960 970 980 990 1000 pF1KA0 IAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQL 2330 2340 2350 2360 2370 2380 1010 1020 1030 pF1KA0 RNIRSKSLKEGLTVQERLKLFESRDLKKD ::::::::::::::::::::::::::::: XP_011 RNIRSKSLKEGLTVQERLKLFESRDLKKD 2390 2400 2410 >-- initn: 615 init1: 615 opt: 615 Z-score: 311.7 bits: 70.5 E(85289): 1.3e-10 Smith-Waterman score: 615; 100.0% identity (100.0% similar) in 86 aa overlap (1-86:33-118) 10 20 30 pF1KA0 MSAAKENPCRKFQANIFNKSKCQNCFKPRE :::::::::::::::::::::::::::::: XP_011 RGRAEPLARRERQAGQACAAAAAAVAAAPTMSAAKENPCRKFQANIFNKSKCQNCFKPRE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 SHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 TTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPR XP_011 TTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPR 130 140 150 160 170 180 >>XP_011522064 (OMIM: 612935) PREDICTED: myosin phosphat (2444 aa) initn: 4706 init1: 2851 opt: 3006 Z-score: 1470.3 bits: 284.9 E(85289): 3.7e-75 Smith-Waterman score: 4135; 68.4% identity (77.8% similar) in 1011 aa overlap (87-968:119-1120) 60 70 80 90 100 110 pF1KA0 TDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQK :::::::::::::::::::::::::::::: XP_011 TDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQK 90 100 110 120 130 140 120 130 140 150 160 170 pF1KA0 FSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVA 150 160 170 180 190 200 180 190 200 210 220 230 pF1KA0 VTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSL 210 220 230 240 250 260 240 250 260 270 280 290 pF1KA0 REPGLESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REPGLESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTP 270 280 290 300 310 320 pF1KA0 NHR--------------------------------------------------------- ::: XP_011 NHRYSCPESPSQELGGPLPSPGPRLPHQMVCSISLSSLDVASQPPAYVDSGSTRGRGTER 330 340 350 360 370 380 pF1KA0 ------------------------------------------------------------ XP_011 LGSAFAFKASRQYATLADVPKAIRISHREAFQVERRRLERRTRARSPGREEVARLFGNER 390 400 410 420 430 440 300 310 320 330 340 350 pF1KA0 -RSQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRSQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPD 450 460 470 480 490 500 360 370 380 390 400 410 pF1KA0 ASASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYY 510 520 530 540 550 560 420 430 440 450 460 470 pF1KA0 RDSVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDSVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTI 570 580 590 600 610 620 480 490 500 510 520 530 pF1KA0 MKHVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKHVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREG 630 640 650 660 670 680 540 550 560 570 580 590 pF1KA0 RSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGM 690 700 710 720 730 740 600 610 620 630 640 650 pF1KA0 LDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAP 750 760 770 780 790 800 660 670 680 690 700 710 pF1KA0 VHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGY 810 820 830 840 850 860 720 730 740 750 760 770 pF1KA0 VLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNA :::. :: .... .... : ::: . ....:.... . . :.. XP_011 VLQTEV----AASPSGAWQRLHRVNQDLQSELEA-QCQRQELITHQIQTLKRSYGEAKDT 870 880 890 900 910 920 780 790 800 810 820 830 pF1KA0 HREEMERELEKSQRSQISSVNSDVEALRRQYLEELQS-VQRELEVLSEQYSQKCLENAHL :.. : :. .: ....:.. ... :...: : .:.. ..:: . :: .. .: : XP_011 IRHH-EAEI-RSLQARLSNAAAEL-AIKEQALAKLKGDLKREQGRVREQLEERQHSEAAL 930 940 950 960 970 980 840 850 860 870 880 pF1KA0 AQALEAERQALRQCQ----RENQELNA--HNQELNNRLAAEITRLRTL---LTGDGGGEA .. :.: .: :.. . ...::: . .: :. :. ::. :. . :. XP_011 SSQLRASEQKLKSAEALLLEKTQELRGLETQQALQRDRQKEVQRLQERIADLSQQLGASE 990 1000 1010 1020 1030 1040 890 900 910 920 930 940 pF1KA0 TGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDK-KYASDKYKDIYTE .. : . : . :.::. :.: : : :... ..:. .: .:. . ... . . : XP_011 QAQRLMEEKLQRNYELLLESCEKEKQALLQNLKEVEDK-ASAYEDQLQGQAQQVETLQKE 1050 1060 1070 1080 1090 950 960 970 980 990 1000 pF1KA0 LSIAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTR : ... .. .:.:::.: XP_011 KLSATFEGSEQVHQLEEQLEAREASVRRLAEHVQSLCDERDLLRQRFQELTERVATSDED 1100 1110 1120 1130 1140 1150 >-- initn: 2011 init1: 1869 opt: 1881 Z-score: 925.1 bits: 184.0 E(85289): 8.6e-45 Smith-Waterman score: 1881; 71.9% identity (81.9% similar) in 463 aa overlap (580-1022:1990-2441) 550 560 570 580 590 600 pF1KA0 PIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDATDGPGTED .: : .. . :: . ...:::. ..: XP_011 QCLEDAESKHSMSMFTLRGRYEEEIRCVVEQLTRTESTLQAERSRVLSQLDAS----VRD 1960 1970 1980 1990 2000 2010 610 620 630 640 650 pF1KA0 AALRMEVDRSPGLPMSDLKTH-NVHVEIEQRWHQVETTPLREE--------------KQV :....: : .. :. . ...:. : :. : :.:. .: XP_011 ---RQDMERHHGEQIQTLEDRFQLKVRELQTIHEEELRTLQEHYSQSLRCLQDTLCLHQG 2020 2030 2040 2050 2060 2070 660 670 680 690 700 pF1KA0 PIAPVHLSSEDGGDRLSTHE---LTSLLEK--ELEQSQKEASDLLEQNRLLQDQLRVALG : : : . . . . : .:.: :. ::: .. . : .. : : .: XP_011 P-HPKALPAPAPNWQATQGEADSMTGLRERIQELEAQMDVMREELGHKDLEGD---AATL 2080 2090 2100 2110 2120 710 720 730 740 750 760 pF1KA0 REQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATI ::. :. :.:::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REKYQRDLESLKATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATI 2130 2140 2150 2160 2170 2180 770 780 790 800 810 820 pF1KA0 SAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQ 2190 2200 2210 2220 2230 2240 830 840 850 860 870 880 pF1KA0 KCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEAT 2250 2260 2270 2280 2290 2300 890 900 910 920 930 940 pF1KA0 GSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELS 2310 2320 2330 2340 2350 2360 950 960 970 980 990 1000 pF1KA0 IAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQL 2370 2380 2390 2400 2410 2420 1010 1020 1030 pF1KA0 RNIRSKSLKEGLTVQERLKLFESRDLKKD :::::::. : .. XP_011 RNIRSKSVIEQVSWDT 2430 2440 >-- initn: 615 init1: 615 opt: 615 Z-score: 311.6 bits: 70.5 E(85289): 1.3e-10 Smith-Waterman score: 615; 100.0% identity (100.0% similar) in 86 aa overlap (1-86:33-118) 10 20 30 pF1KA0 MSAAKENPCRKFQANIFNKSKCQNCFKPRE :::::::::::::::::::::::::::::: XP_011 RGRAEPLARRERQAGQACAAAAAAVAAAPTMSAAKENPCRKFQANIFNKSKCQNCFKPRE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 SHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 TTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPR XP_011 TTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPR 130 140 150 160 170 180 1038 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 19:51:57 2016 done: Wed Nov 2 19:51:59 2016 Total Scan time: 13.910 Total Display time: 0.470 Function used was FASTA [36.3.4 Apr, 2011]