FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0869, 1113 aa 1>>>pF1KA0869 1113 - 1113 aa - 1113 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.4887+/-0.000433; mu= 3.5749+/- 0.027 mean_var=249.5398+/-52.648, 0's: 0 Z-trim(118.5): 139 B-trim: 1343 in 2/59 Lambda= 0.081190 statistics sampled from 31391 (31545) to 31391 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.69), E-opt: 0.2 (0.37), width: 16 Scan time: 16.530 The best scores are: opt bits E(85289) NP_056053 (OMIM: 610533,615602) protein KIBRA isof (1113) 7197 857.3 0 XP_005265910 (OMIM: 610533,615602) PREDICTED: prot (1112) 7178 855.1 0 NP_001155133 (OMIM: 610533,615602) protein KIBRA i (1119) 7175 854.7 0 NP_001155134 (OMIM: 610533,615602) protein KIBRA i (1118) 7156 852.5 0 XP_005265907 (OMIM: 610533,615602) PREDICTED: prot (1124) 6284 750.4 1.4e-215 XP_016864767 (OMIM: 610533,615602) PREDICTED: prot (1030) 5594 669.5 2.8e-191 XP_011532793 (OMIM: 610533,615602) PREDICTED: prot (1174) 5135 615.8 4.7e-175 XP_016864765 (OMIM: 610533,615602) PREDICTED: prot (1173) 5116 613.6 2.2e-174 XP_011532790 (OMIM: 610533,615602) PREDICTED: prot (1179) 5115 613.4 2.4e-174 XP_011532789 (OMIM: 610533,615602) PREDICTED: prot (1180) 5113 613.2 2.8e-174 XP_011532792 (OMIM: 610533,615602) PREDICTED: prot (1178) 5096 611.2 1.1e-173 XP_011532791 (OMIM: 610533,615602) PREDICTED: prot (1179) 5094 611.0 1.3e-173 XP_016864766 (OMIM: 610533,615602) PREDICTED: prot (1091) 4222 508.8 7e-143 XP_011532788 (OMIM: 610533,615602) PREDICTED: prot (1184) 4222 508.8 7.4e-143 XP_011532787 (OMIM: 610533,615602) PREDICTED: prot (1185) 4222 508.8 7.5e-143 XP_005265625 (OMIM: 602625) PREDICTED: membrane-as (1478) 329 52.9 1.6e-05 XP_006713473 (OMIM: 602625) PREDICTED: membrane-as (1479) 329 52.9 1.6e-05 XP_011532538 (OMIM: 602625) PREDICTED: membrane-as (1480) 329 52.9 1.6e-05 XP_016868341 (OMIM: 606382) PREDICTED: membrane-as (1284) 297 49.1 0.0002 XP_016868340 (OMIM: 606382) PREDICTED: membrane-as (1298) 297 49.1 0.0002 XP_016868339 (OMIM: 606382) PREDICTED: membrane-as (1326) 297 49.1 0.0002 XP_016868338 (OMIM: 606382) PREDICTED: membrane-as (1332) 297 49.1 0.0002 XP_016868337 (OMIM: 606382) PREDICTED: membrane-as (1334) 297 49.1 0.0002 XP_016868336 (OMIM: 606382) PREDICTED: membrane-as (1377) 297 49.2 0.00021 XP_011515022 (OMIM: 606382) PREDICTED: membrane-as (1377) 297 49.2 0.00021 XP_011515021 (OMIM: 606382) PREDICTED: membrane-as (1377) 297 49.2 0.00021 NP_001288057 (OMIM: 606382) membrane-associated gu (1441) 297 49.2 0.00022 NP_036433 (OMIM: 606382) membrane-associated guany (1455) 297 49.2 0.00022 XP_016868335 (OMIM: 606382) PREDICTED: membrane-as (1483) 297 49.2 0.00022 XP_016868334 (OMIM: 606382) PREDICTED: membrane-as (1495) 297 49.2 0.00022 XP_011515020 (OMIM: 606382) PREDICTED: membrane-as (1497) 297 49.2 0.00022 XP_016868333 (OMIM: 606382) PREDICTED: membrane-as (1498) 297 49.2 0.00022 XP_016868332 (OMIM: 606382) PREDICTED: membrane-as (1526) 297 49.2 0.00023 XP_016868331 (OMIM: 606382) PREDICTED: membrane-as (1538) 297 49.2 0.00023 XP_016868330 (OMIM: 606382) PREDICTED: membrane-as (1539) 297 49.2 0.00023 XP_016868329 (OMIM: 606382) PREDICTED: membrane-as (1540) 297 49.2 0.00023 XP_005270794 (OMIM: 615943) PREDICTED: membrane-as (1125) 286 47.8 0.00044 NP_690864 (OMIM: 615943) membrane-associated guany (1125) 286 47.8 0.00044 XP_016856463 (OMIM: 615943) PREDICTED: membrane-as (1145) 286 47.8 0.00044 XP_011539510 (OMIM: 615943) PREDICTED: membrane-as (1253) 286 47.8 0.00047 NP_001136254 (OMIM: 615943) membrane-associated gu (1481) 286 47.9 0.00054 >>NP_056053 (OMIM: 610533,615602) protein KIBRA isoform (1113 aa) initn: 7197 init1: 7197 opt: 7197 Z-score: 4569.3 bits: 857.3 E(85289): 0 Smith-Waterman score: 7197; 100.0% identity (100.0% similar) in 1113 aa overlap (1-1113:1-1113) 10 20 30 40 50 60 pF1KA0 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 YNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 YNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLED 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 SWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSP 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 NSLERRSVRMKRPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEQLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 NSLERRSVRMKRPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEQLE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 QAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDVHRLRGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 QAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDVHRLRGQ 1030 1040 1050 1060 1070 1080 1090 1100 1110 pF1KA0 SCKEPPEVQSFREKMAFFTRPRMNIPALSADDV ::::::::::::::::::::::::::::::::: NP_056 SCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1090 1100 1110 >>XP_005265910 (OMIM: 610533,615602) PREDICTED: protein (1112 aa) initn: 6770 init1: 6770 opt: 7178 Z-score: 4557.3 bits: 855.1 E(85289): 0 Smith-Waterman score: 7178; 99.9% identity (99.9% similar) in 1113 aa overlap (1-1113:1-1112) 10 20 30 40 50 60 pF1KA0 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 YNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLED 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 SWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSP 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 NSLERRSVRMKRPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEQLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSLERRSVRMKRPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEQLE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 QAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDVHRLRGQ :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: XP_005 QAKSHGEKELPQWLREDERFRLLLRMLEKR-MDRAEHKGELQTDKMMRAAAKDVHRLRGQ 1030 1040 1050 1060 1070 1090 1100 1110 pF1KA0 SCKEPPEVQSFREKMAFFTRPRMNIPALSADDV ::::::::::::::::::::::::::::::::: XP_005 SCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1080 1090 1100 1110 >>NP_001155133 (OMIM: 610533,615602) protein KIBRA isofo (1119 aa) initn: 6291 init1: 6291 opt: 7175 Z-score: 4555.4 bits: 854.7 E(85289): 0 Smith-Waterman score: 7175; 99.5% identity (99.5% similar) in 1119 aa overlap (1-1113:1-1119) 10 20 30 40 50 60 pF1KA0 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 YNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLED 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 SWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSP 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR 910 920 930 940 950 960 970 980 990 1000 1010 pF1KA0 NSLERRSVRMKRPS------SVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKE :::::::::::::: :::::::::::::::::::::::::::::::::::::::: NP_001 NSLERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKE 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA0 LKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDV 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 pF1KA0 HRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV ::::::::::::::::::::::::::::::::::::::: NP_001 HRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1090 1100 1110 >>NP_001155134 (OMIM: 610533,615602) protein KIBRA isofo (1118 aa) initn: 6707 init1: 6291 opt: 7156 Z-score: 4543.4 bits: 852.5 E(85289): 0 Smith-Waterman score: 7156; 99.4% identity (99.4% similar) in 1119 aa overlap (1-1113:1-1118) 10 20 30 40 50 60 pF1KA0 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 YNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLED 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 SWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSP 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR 910 920 930 940 950 960 970 980 990 1000 1010 pF1KA0 NSLERRSVRMKRPS------SVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKE :::::::::::::: :::::::::::::::::::::::::::::::::::::::: NP_001 NSLERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKE 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA0 LKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDV :::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::: NP_001 LKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKR-MDRAEHKGELQTDKMMRAAAKDV 1030 1040 1050 1060 1070 1080 1090 1100 1110 pF1KA0 HRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV ::::::::::::::::::::::::::::::::::::::: NP_001 HRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1080 1090 1100 1110 >>XP_005265907 (OMIM: 610533,615602) PREDICTED: protein (1124 aa) initn: 6277 init1: 5236 opt: 6284 Z-score: 3991.3 bits: 750.4 E(85289): 1.4e-215 Smith-Waterman score: 7155; 99.0% identity (99.0% similar) in 1124 aa overlap (1-1113:1-1124) 10 20 30 40 50 60 pF1KA0 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW 730 740 750 760 770 780 790 800 810 820 830 pF1KA0 YNLLSYKYLKKQSRELKPVGVMAPASGPAST-----DAVSALLEQTAVELEKRQEGRSST ::::::::::::::::::::::::::::::: :::::::::::::::::::::::: XP_005 YNLLSYKYLKKQSRELKPVGVMAPASGPASTVSWDQDAVSALLEQTAVELEKRQEGRSST 790 800 810 820 830 840 840 850 860 870 880 890 pF1KA0 QTLEDSWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QTLEDSWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTET 850 860 870 880 890 900 900 910 920 930 940 950 pF1KA0 PAPSPTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PAPSPTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKK 910 920 930 940 950 960 960 970 980 990 1000 pF1KA0 PPFVRNSLERRSVRMKRPS------SVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEI ::::::::::::::::::: ::::::::::::::::::::::::::::::::::: XP_005 PPFVRNSLERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEI 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KA0 SVLKELKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SVLKELKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRA 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 pF1KA0 AAKDVHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV :::::::::::::::::::::::::::::::::::::::::::: XP_005 AAKDVHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1090 1100 1110 1120 >>XP_016864767 (OMIM: 610533,615602) PREDICTED: protein (1030 aa) initn: 5587 init1: 4546 opt: 5594 Z-score: 3555.0 bits: 669.5 E(85289): 2.8e-191 Smith-Waterman score: 6465; 98.9% identity (98.9% similar) in 1030 aa overlap (95-1113:1-1030) 70 80 90 100 110 120 pF1KA0 PQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELA :::::::::::::::::::::::::::::: XP_016 MLKDYLVVAQEALSAQKEIYQVKQQRLELA 10 20 30 130 140 150 160 170 180 pF1KA0 QQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHE 40 50 60 70 80 90 190 200 210 220 230 240 pF1KA0 LQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAM 100 110 120 130 140 150 250 260 270 280 290 300 pF1KA0 LKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAEKVRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAEKVRL 160 170 180 190 200 210 310 320 330 340 350 360 pF1KA0 RLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPRKWTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPRKWTQ 220 230 240 250 260 270 370 380 390 400 410 420 pF1KA0 GEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLHSQLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLHSQLK 280 290 300 310 320 330 430 440 450 460 470 480 pF1KA0 SLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSKVEFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSKVEFL 340 350 360 370 380 390 490 500 510 520 530 540 pF1KA0 LLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSLSSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSLSSPS 400 410 420 430 440 450 550 560 570 580 590 600 pF1KA0 PPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQLGQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQLGQA 460 470 480 490 500 510 610 620 630 640 650 660 pF1KA0 VNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGATRIQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGATRIQI 520 530 540 550 560 570 670 680 690 700 710 720 pF1KA0 ALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDASDTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDASDTL 580 590 600 610 620 630 730 740 750 760 770 780 pF1KA0 VFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRWYNLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRWYNLL 640 650 660 670 680 690 790 800 810 820 830 pF1KA0 SYKYLKKQSRELKPVGVMAPASGPAST-----DAVSALLEQTAVELEKRQEGRSSTQTLE ::::::::::::::::::::::::::: :::::::::::::::::::::::::::: XP_016 SYKYLKKQSRELKPVGVMAPASGPASTVSWDQDAVSALLEQTAVELEKRQEGRSSTQTLE 700 710 720 730 740 750 840 850 860 870 880 890 pF1KA0 DSWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPS 760 770 780 790 800 810 900 910 920 930 940 950 pF1KA0 PTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFV 820 830 840 850 860 870 960 970 980 990 1000 1010 pF1KA0 RNSLERRSVRMKRPS------SVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLK ::::::::::::::: ::::::::::::::::::::::::::::::::::::::: XP_016 RNSLERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLK 880 890 900 910 920 930 1020 1030 1040 1050 1060 1070 pF1KA0 ELKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKD 940 950 960 970 980 990 1080 1090 1100 1110 pF1KA0 VHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV :::::::::::::::::::::::::::::::::::::::: XP_016 VHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1000 1010 1020 1030 >>XP_011532793 (OMIM: 610533,615602) PREDICTED: protein (1174 aa) initn: 5126 init1: 5126 opt: 5135 Z-score: 3263.7 bits: 615.8 E(85289): 4.7e-175 Smith-Waterman score: 6848; 94.7% identity (94.7% similar) in 1145 aa overlap (30-1113:30-1174) 10 20 30 40 50 60 pF1KA0 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE ::::::::::::::::::::::::::::::: XP_011 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE 250 260 270 280 290 300 310 pF1KA0 KVRLRLRYEEAKRR---------------------------------------------- :::::::::::::: XP_011 KVRLRLRYEEAKRRLSCQCGQATPSNSELTHYQLPQASSKTARHLYLDSHFLFSLKRTTL 310 320 330 340 350 360 320 330 340 350 pF1KA0 ---------------IANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISP ::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLGSVPSCRNACLRWIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISP 370 380 390 400 410 420 360 370 380 390 400 410 pF1KA0 RKWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATL 430 440 450 460 470 480 420 430 440 450 460 470 pF1KA0 HSQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HSQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQS 490 500 510 520 530 540 480 490 500 510 520 530 pF1KA0 KVEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSS 550 560 570 580 590 600 540 550 560 570 580 590 pF1KA0 LSSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGK 610 620 630 640 650 660 600 610 620 630 640 650 pF1KA0 QLGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGA 670 680 690 700 710 720 660 670 680 690 700 710 pF1KA0 TRIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLD 730 740 750 760 770 780 720 730 740 750 760 770 pF1KA0 ASDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTR 790 800 810 820 830 840 780 790 800 810 820 830 pF1KA0 WYNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WYNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLE 850 860 870 880 890 900 840 850 860 870 880 890 pF1KA0 DSWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPS 910 920 930 940 950 960 900 910 920 930 940 950 pF1KA0 PTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFV 970 980 990 1000 1010 1020 960 970 980 990 1000 1010 pF1KA0 RNSLERRSVRMKRPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RNSLERRSVRMKRPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEQL 1030 1040 1050 1060 1070 1080 1020 1030 1040 1050 1060 1070 pF1KA0 EQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDVHRLRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDVHRLRG 1090 1100 1110 1120 1130 1140 1080 1090 1100 1110 pF1KA0 QSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV :::::::::::::::::::::::::::::::::: XP_011 QSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1150 1160 1170 >>XP_016864765 (OMIM: 610533,615602) PREDICTED: protein (1173 aa) initn: 4699 init1: 4699 opt: 5116 Z-score: 3251.7 bits: 613.6 E(85289): 2.2e-174 Smith-Waterman score: 6829; 94.6% identity (94.6% similar) in 1145 aa overlap (30-1113:30-1173) 10 20 30 40 50 60 pF1KA0 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE ::::::::::::::::::::::::::::::: XP_016 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE 250 260 270 280 290 300 310 pF1KA0 KVRLRLRYEEAKRR---------------------------------------------- :::::::::::::: XP_016 KVRLRLRYEEAKRRLSCQCGQATPSNSELTHYQLPQASSKTARHLYLDSHFLFSLKRTTL 310 320 330 340 350 360 320 330 340 350 pF1KA0 ---------------IANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISP ::::::::::::::::::::::::::::::::::::::::::::: XP_016 NLGSVPSCRNACLRWIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISP 370 380 390 400 410 420 360 370 380 390 400 410 pF1KA0 RKWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATL 430 440 450 460 470 480 420 430 440 450 460 470 pF1KA0 HSQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQS 490 500 510 520 530 540 480 490 500 510 520 530 pF1KA0 KVEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSS 550 560 570 580 590 600 540 550 560 570 580 590 pF1KA0 LSSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGK 610 620 630 640 650 660 600 610 620 630 640 650 pF1KA0 QLGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGA 670 680 690 700 710 720 660 670 680 690 700 710 pF1KA0 TRIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLD 730 740 750 760 770 780 720 730 740 750 760 770 pF1KA0 ASDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTR 790 800 810 820 830 840 780 790 800 810 820 830 pF1KA0 WYNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WYNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLE 850 860 870 880 890 900 840 850 860 870 880 890 pF1KA0 DSWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPS 910 920 930 940 950 960 900 910 920 930 940 950 pF1KA0 PTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFV 970 980 990 1000 1010 1020 960 970 980 990 1000 1010 pF1KA0 RNSLERRSVRMKRPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RNSLERRSVRMKRPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEQL 1030 1040 1050 1060 1070 1080 1020 1030 1040 1050 1060 1070 pF1KA0 EQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDVHRLRG ::::::::::::::::::::::::::::::: :::::::::::::::::::::::::::: XP_016 EQAKSHGEKELPQWLREDERFRLLLRMLEKR-MDRAEHKGELQTDKMMRAAAKDVHRLRG 1090 1100 1110 1120 1130 1080 1090 1100 1110 pF1KA0 QSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV :::::::::::::::::::::::::::::::::: XP_016 QSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1140 1150 1160 1170 >>XP_011532790 (OMIM: 610533,615602) PREDICTED: protein (1179 aa) initn: 5112 init1: 3165 opt: 5115 Z-score: 3251.0 bits: 613.4 E(85289): 2.4e-174 Smith-Waterman score: 6828; 94.3% identity (94.3% similar) in 1150 aa overlap (30-1113:30-1179) 10 20 30 40 50 60 pF1KA0 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE ::::::::::::::::::::::::::::::: XP_011 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE 250 260 270 280 290 300 310 pF1KA0 KVRLRLRYEEAKRR---------------------------------------------- :::::::::::::: XP_011 KVRLRLRYEEAKRRLSCQCGQATPSNSELTHYQLPQASSKTARHLYLDSHFLFSLKRTTL 310 320 330 340 350 360 320 330 340 350 pF1KA0 ---------------IANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISP ::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLGSVPSCRNACLRWIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISP 370 380 390 400 410 420 360 370 380 390 400 410 pF1KA0 RKWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATL 430 440 450 460 470 480 420 430 440 450 460 470 pF1KA0 HSQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HSQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQS 490 500 510 520 530 540 480 490 500 510 520 530 pF1KA0 KVEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSS 550 560 570 580 590 600 540 550 560 570 580 590 pF1KA0 LSSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGK 610 620 630 640 650 660 600 610 620 630 640 650 pF1KA0 QLGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGA 670 680 690 700 710 720 660 670 680 690 700 710 pF1KA0 TRIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLD 730 740 750 760 770 780 720 730 740 750 760 770 pF1KA0 ASDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTR 790 800 810 820 830 840 780 790 800 810 820 830 pF1KA0 WYNLLSYKYLKKQSRELKPVGVMAPASGPAST-----DAVSALLEQTAVELEKRQEGRSS :::::::::::::::::::::::::::::::: ::::::::::::::::::::::: XP_011 WYNLLSYKYLKKQSRELKPVGVMAPASGPASTVSWDQDAVSALLEQTAVELEKRQEGRSS 850 860 870 880 890 900 840 850 860 870 880 890 pF1KA0 TQTLEDSWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQTLEDSWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTE 910 920 930 940 950 960 900 910 920 930 940 950 pF1KA0 TPAPSPTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPAPSPTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSK 970 980 990 1000 1010 1020 960 970 980 990 1000 1010 pF1KA0 KPPFVRNSLERRSVRMKRPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPPFVRNSLERRSVRMKRPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKE 1030 1040 1050 1060 1070 1080 1020 1030 1040 1050 1060 1070 pF1KA0 LKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDV 1090 1100 1110 1120 1130 1140 1080 1090 1100 1110 pF1KA0 HRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV ::::::::::::::::::::::::::::::::::::::: XP_011 HRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1150 1160 1170 >>XP_011532789 (OMIM: 610533,615602) PREDICTED: protein (1180 aa) initn: 4220 init1: 4220 opt: 5113 Z-score: 3249.7 bits: 613.2 E(85289): 2.8e-174 Smith-Waterman score: 6826; 94.2% identity (94.2% similar) in 1151 aa overlap (30-1113:30-1180) 10 20 30 40 50 60 pF1KA0 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE ::::::::::::::::::::::::::::::: XP_011 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE 250 260 270 280 290 300 310 pF1KA0 KVRLRLRYEEAKRR---------------------------------------------- :::::::::::::: XP_011 KVRLRLRYEEAKRRLSCQCGQATPSNSELTHYQLPQASSKTARHLYLDSHFLFSLKRTTL 310 320 330 340 350 360 320 330 340 350 pF1KA0 ---------------IANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISP ::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLGSVPSCRNACLRWIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISP 370 380 390 400 410 420 360 370 380 390 400 410 pF1KA0 RKWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATL 430 440 450 460 470 480 420 430 440 450 460 470 pF1KA0 HSQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HSQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQS 490 500 510 520 530 540 480 490 500 510 520 530 pF1KA0 KVEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSS 550 560 570 580 590 600 540 550 560 570 580 590 pF1KA0 LSSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGK 610 620 630 640 650 660 600 610 620 630 640 650 pF1KA0 QLGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGA 670 680 690 700 710 720 660 670 680 690 700 710 pF1KA0 TRIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLD 730 740 750 760 770 780 720 730 740 750 760 770 pF1KA0 ASDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTR 790 800 810 820 830 840 780 790 800 810 820 830 pF1KA0 WYNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WYNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLE 850 860 870 880 890 900 840 850 860 870 880 890 pF1KA0 DSWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPS 910 920 930 940 950 960 900 910 920 930 940 950 pF1KA0 PTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFV 970 980 990 1000 1010 1020 960 970 980 990 1000 1010 pF1KA0 RNSLERRSVRMKRPS------SVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLK ::::::::::::::: ::::::::::::::::::::::::::::::::::::::: XP_011 RNSLERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLK 1030 1040 1050 1060 1070 1080 1020 1030 1040 1050 1060 1070 pF1KA0 ELKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKD 1090 1100 1110 1120 1130 1140 1080 1090 1100 1110 pF1KA0 VHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV :::::::::::::::::::::::::::::::::::::::: XP_011 VHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1150 1160 1170 1180 1113 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 09:17:21 2016 done: Sat Nov 5 09:17:23 2016 Total Scan time: 16.530 Total Display time: 0.400 Function used was FASTA [36.3.4 Apr, 2011]