Result of FASTA (ccds) for
pF1KA0926
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0926, 1429 aa
1>>>pF1KA0926 1429 - 1429 aa - 1429 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.0468+/-0.00102; mu= 10.2939+/- 0.061
mean_var=144.6051+/-29.362, 0's: 0 Z-trim(108.8): 65 B-trim: 0 in 0/51
Lambda= 0.106655
statistics sampled from 10382 (10444) to 10382 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.664), E-opt: 0.2 (0.321), width: 16
Scan time: 3.830
The best scores are: opt bits E(32554)
CCDS42245.1 NLRP1 gene_id:22861|Hs108|chr17 (1429) 9701 1505.6 0
CCDS42246.1 NLRP1 gene_id:22861|Hs108|chr17 (1473) 8583 1333.5 0
CCDS32537.1 NLRP1 gene_id:22861|Hs108|chr17 (1375) 8565 1330.8 0
CCDS58508.1 NLRP1 gene_id:22861|Hs108|chr17 (1399) 6545 1019.9 0
CCDS42244.1 NLRP1 gene_id:22861|Hs108|chr17 (1443) 6545 1019.9 0
CCDS62784.1 NLRP12 gene_id:91662|Hs108|chr19 (1004) 1095 181.3 1.3e-44
CCDS12864.1 NLRP12 gene_id:91662|Hs108|chr19 (1061) 1095 181.3 1.3e-44
CCDS62785.1 NLRP12 gene_id:91662|Hs108|chr19 (1062) 1095 181.3 1.3e-44
CCDS1633.1 NLRP3 gene_id:114548|Hs108|chr1 ( 922) 976 162.9 3.8e-39
CCDS44346.1 NLRP3 gene_id:114548|Hs108|chr1 ( 979) 976 163.0 4e-39
CCDS44347.1 NLRP3 gene_id:114548|Hs108|chr1 ( 979) 976 163.0 4e-39
CCDS1632.1 NLRP3 gene_id:114548|Hs108|chr1 (1036) 976 163.0 4.2e-39
CCDS12912.1 NLRP7 gene_id:199713|Hs108|chr19 (1009) 954 159.6 4.3e-38
CCDS7776.1 NLRP14 gene_id:338323|Hs108|chr11 (1093) 896 150.7 2.2e-35
CCDS12936.1 NLRP4 gene_id:147945|Hs108|chr19 ( 994) 879 148.0 1.3e-34
CCDS60680.1 NLRP6 gene_id:171389|Hs108|chr11 ( 891) 817 138.5 8.6e-32
CCDS7693.1 NLRP6 gene_id:171389|Hs108|chr11 ( 892) 817 138.5 8.6e-32
CCDS33109.1 NLRP7 gene_id:199713|Hs108|chr19 ( 980) 798 135.6 7.1e-31
CCDS46183.1 NLRP7 gene_id:199713|Hs108|chr19 (1037) 798 135.6 7.4e-31
CCDS54318.1 NLRP2 gene_id:55655|Hs108|chr19 (1039) 790 134.3 1.7e-30
CCDS54319.1 NLRP2 gene_id:55655|Hs108|chr19 (1040) 790 134.3 1.7e-30
CCDS12913.1 NLRP2 gene_id:55655|Hs108|chr19 (1062) 790 134.4 1.8e-30
CCDS7784.1 NLRP10 gene_id:338322|Hs108|chr11 ( 655) 721 123.6 1.8e-27
CCDS54288.1 CARD8 gene_id:22900|Hs108|chr19 ( 392) 654 113.2 1.5e-24
CCDS12712.2 CARD8 gene_id:22900|Hs108|chr19 ( 487) 654 113.3 1.8e-24
CCDS54289.1 CARD8 gene_id:22900|Hs108|chr19 ( 537) 654 113.3 2e-24
CCDS82402.1 NLRP8 gene_id:126205|Hs108|chr19 (1029) 658 114.0 2.2e-24
CCDS12937.1 NLRP8 gene_id:126205|Hs108|chr19 (1048) 658 114.0 2.3e-24
CCDS7697.1 RNH1 gene_id:6050|Hs108|chr11 ( 461) 469 84.8 6.4e-16
CCDS12938.1 NLRP5 gene_id:126206|Hs108|chr19 (1200) 464 84.2 2.5e-15
CCDS12934.1 NLRP9 gene_id:338321|Hs108|chr19 ( 991) 461 83.7 2.9e-15
CCDS74458.1 NLRP11 gene_id:204801|Hs108|chr19 ( 934) 406 75.2 9.7e-13
CCDS12935.1 NLRP11 gene_id:204801|Hs108|chr19 (1033) 406 75.3 1.1e-12
CCDS33119.1 NLRP13 gene_id:126204|Hs108|chr19 (1043) 396 73.7 3.1e-12
CCDS82401.1 NLRP13 gene_id:126204|Hs108|chr19 (1036) 393 73.3 4.3e-12
>>CCDS42245.1 NLRP1 gene_id:22861|Hs108|chr17 (1429 aa)
initn: 9701 init1: 9701 opt: 9701 Z-score: 8068.9 bits: 1505.6 E(32554): 0
Smith-Waterman score: 9701; 100.0% identity (100.0% similar) in 1429 aa overlap (1-1429:1-1429)
10 20 30 40 50 60
pF1KA0 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 KELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 KELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPP
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 ARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 ARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPS
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420
pF1KA0 QMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
:::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 QMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
1390 1400 1410 1420
>>CCDS42246.1 NLRP1 gene_id:22861|Hs108|chr17 (1473 aa)
initn: 9024 init1: 8583 opt: 8583 Z-score: 7139.0 bits: 1333.5 E(32554): 0
Smith-Waterman score: 9529; 97.0% identity (97.0% similar) in 1461 aa overlap (1-1417:1-1461)
10 20 30 40 50 60
pF1KA0 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
1210 1220 1230 1240 1250 1260
1270
pF1KA0 K--------------------------------------------ELELCYRSPGEDQLF
: :::::::::::::::
CCDS42 KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KA0 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KA0 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC
1390 1400 1410 1420 1430 1440
1400 1410 1420
pF1KA0 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
:::::::::::::::::::::
CCDS42 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
1450 1460 1470
>>CCDS32537.1 NLRP1 gene_id:22861|Hs108|chr17 (1375 aa)
initn: 9023 init1: 7094 opt: 8565 Z-score: 7124.5 bits: 1330.8 E(32554): 0
Smith-Waterman score: 8791; 96.5% identity (96.5% similar) in 1357 aa overlap (1-1309:1-1357)
10 20 30 40 50 60
pF1KA0 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070
pF1KA0 ASHVAQANLKLLDVSKIFPIAEIA----EESSPEVVPVELLCVPSPASQGDLHTKPLGTD
:::::::::::::::::::::::: ::::::::::::::::::::::::::::::::
CCDS32 ASHVAQANLKLLDVSKIFPIAEIAGKSHEESSPEVVPVELLCVPSPASQGDLHTKPLGTD
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KA0 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KA0 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KA0 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD
1210 1220 1230 1240 1250 1260
1260 1270
pF1KA0 CSIRK--------------------------------------------ELELCYRSPGE
::::: :::::::::::
CCDS32 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KA0 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAP
:::::::::::::::::::::::::::::::::::::
CCDS32 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGRNTSQPWNLRCNRDARRY
1330 1340 1350 1360 1370
1340 1350 1360 1370 1380 1390
pF1KA0 QLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSW
>>CCDS58508.1 NLRP1 gene_id:22861|Hs108|chr17 (1399 aa)
initn: 9500 init1: 6545 opt: 6545 Z-score: 5444.6 bits: 1019.9 E(32554): 0
Smith-Waterman score: 9444; 97.9% identity (97.9% similar) in 1429 aa overlap (1-1429:1-1399)
10 20 30 40 50 60
pF1KA0 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG---
910 920 930 940 950
970 980 990 1000 1010 1020
pF1KA0 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
:::::::::::::::::::::::::::::::::
CCDS58 ---------------------------KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KA0 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KA0 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190 1200
pF1KA0 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
1120 1130 1140 1150 1160 1170
1210 1220 1230 1240 1250 1260
pF1KA0 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
1180 1190 1200 1210 1220 1230
1270 1280 1290 1300 1310 1320
pF1KA0 KELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 KELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPP
1240 1250 1260 1270 1280 1290
1330 1340 1350 1360 1370 1380
pF1KA0 ARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 ARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPS
1300 1310 1320 1330 1340 1350
1390 1400 1410 1420
pF1KA0 QMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
:::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 QMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
1360 1370 1380 1390
>>CCDS42244.1 NLRP1 gene_id:22861|Hs108|chr17 (1443 aa)
initn: 8382 init1: 6545 opt: 6545 Z-score: 5444.4 bits: 1019.9 E(32554): 0
Smith-Waterman score: 9346; 95.0% identity (95.0% similar) in 1473 aa overlap (1-1429:1-1443)
10 20 30 40 50 60
pF1KA0 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG---
910 920 930 940 950
970 980 990 1000 1010 1020
pF1KA0 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
:::::::::::::::::::::::::::::::::
CCDS42 ---------------------------KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KA0 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KA0 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190 1200
pF1KA0 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
1120 1130 1140 1150 1160 1170
1210 1220 1230 1240 1250 1260
pF1KA0 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
1180 1190 1200 1210 1220 1230
1270
pF1KA0 K--------------------------------------------ELELCYRSPGEDQLF
: :::::::::::::::
CCDS42 KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF
1240 1250 1260 1270 1280 1290
1280 1290 1300 1310 1320 1330
pF1KA0 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH
1300 1310 1320 1330 1340 1350
1340 1350 1360 1370 1380 1390
pF1KA0 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC
1360 1370 1380 1390 1400 1410
1400 1410 1420
pF1KA0 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
:::::::::::::::::::::::::::::::::
CCDS42 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
1420 1430 1440
>>CCDS62784.1 NLRP12 gene_id:91662|Hs108|chr19 (1004 aa)
initn: 1945 init1: 544 opt: 1095 Z-score: 914.6 bits: 181.3 E(32554): 1.3e-44
Smith-Waterman score: 1699; 41.4% identity (67.2% similar) in 735 aa overlap (273-971:152-876)
250 260 270 280 290 300
pF1KA0 QAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPD
......:.:::. . : ..:. . .
CCDS62 RKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLV-KEH---SNPM--QVQQQ
130 140 150 160 170
310 320 330 340 350
pF1KA0 YVEENRGHL---------IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWG
.. .::: :.:. :: : . :: : :..::::::::: ::..: :.
CCDS62 LLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWA
180 190 200 210 220 230
360 370 380 390 400 410
pF1KA0 RGQLYGDRFQHVFYFSCRELAQSKV-VSLAELIGKDGTATPAPIRQILSRPERLLFILDG
:.:. ::...::..:::. :: . :. .:: . ::..... :::::::.::
CCDS62 DGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDG
240 250 260 270 280 290
420 430 440 450 460 470
pF1KA0 VDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLE
:: ...:.. :: : . .:.. ::.::. : .::: :.:::.: :::..: ::
CCDS62 FDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLE
300 310 320 330 340 350
480 490 500 510 520 530
pF1KA0 QARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLM
. : ::.:::::. ::::::.:: . .:: ..: :..:. :...:.:: : :..::::.
CCDS62 HPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQ
360 370 380 390 400 410
540 550 560 570 580
pF1KA0 QQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGPQL------RDLCSLAAEGIWQKKTL
::.. : ::.:::.. . :: . .: .: .:.: : ::::::.:.:..: :
CCDS62 QQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKIL
420 430 440 450 460 470
590 600 610 620 630 640
pF1KA0 FSPDDLRKHGLDGAIISTFLKMGILQEH-PIPLSYSFIHLCFQEFFAAMSYVL-EDEKGR
: .::::::::: .:.::.:.:.:. :::::: :::::::: :.: : : :
CCDS62 FEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGA
480 490 500 510 520 530
650 660 670 680 690 700
pF1KA0 GKHSNCIIDLEKTLEAYGI-HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNL
: . :. . : :.. . : : :.:::.:::..: . ..:. . ..: .:
CCDS62 GPDQ----DVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDL
540 550 560 570 580 590
710 720 730 740 750
pF1KA0 MQWVPSLQL----LLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMC-VETDMELLVCT
.::. : :: ::: . :::: ... :. :...::. . . . . :: .: .
CCDS62 LQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSS
600 610 620 630 640 650
760 770 780 790 800
pF1KA0 FCIKFSRHVKKLQLI--------EGRQHRSTWSPTMVV-LFRWVPVTDAYWQILFSVLKV
::.: : .. :.: : : . :. . :..: : . . . ::: . : ..: .
CCDS62 FCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCT
660 670 680 690 700 710
810 820 830 840 850 860
pF1KA0 TRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQT
. :: ::.: :.:. .:: ::. ::.: : :..::: : ... :.::. .: ::..
CCDS62 NPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKN
720 730 740 750 760 770
870 880 890 900 910 920
pF1KA0 LTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKE
::..::: : . : ::. ::.:.:.:: .:: .: : : ::..::::...: : :
CCDS62 LTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVE
780 790 800 810 820 830
930 940 950 960 970 980
pF1KA0 LDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLIFSR
::: : :.:.:.::::.:::::.:.: : : :. .::
CCDS62 LDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDL
840 850 860 870 880 890
990 1000 1010 1020 1030 1040
pF1KA0 RKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFPIAEIAEE
CCDS62 SLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGINQTLTDLYLTNN
900 910 920 930 940 950
>>CCDS12864.1 NLRP12 gene_id:91662|Hs108|chr19 (1061 aa)
initn: 2262 init1: 544 opt: 1095 Z-score: 914.3 bits: 181.3 E(32554): 1.3e-44
Smith-Waterman score: 1719; 40.2% identity (65.7% similar) in 808 aa overlap (273-1035:152-949)
250 260 270 280 290 300
pF1KA0 QAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPD
......:.:::. . : ..:. . .
CCDS12 RKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLV-KEH---SNPM--QVQQQ
130 140 150 160 170
310 320 330 340 350
pF1KA0 YVEENRGHL---------IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWG
.. .::: :.:. :: : . :: : :..::::::::: ::..: :.
CCDS12 LLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWA
180 190 200 210 220 230
360 370 380 390 400 410
pF1KA0 RGQLYGDRFQHVFYFSCRELAQSKV-VSLAELIGKDGTATPAPIRQILSRPERLLFILDG
:.:. ::...::..:::. :: . :. .:: . ::..... :::::::.::
CCDS12 DGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDG
240 250 260 270 280 290
420 430 440 450 460 470
pF1KA0 VDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLE
:: ...:.. :: : . .:.. ::.::. : .::: :.:::.: :::..: ::
CCDS12 FDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLE
300 310 320 330 340 350
480 490 500 510 520 530
pF1KA0 QARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLM
. : ::.:::::. ::::::.:: . .:: ..: :..:. :...:.:: : :..::::.
CCDS12 HPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQ
360 370 380 390 400 410
540 550 560 570 580
pF1KA0 QQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGPQL------RDLCSLAAEGIWQKKTL
::.. : ::.:::.. . :: . .: .: .:.: : ::::::.:.:..: :
CCDS12 QQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKIL
420 430 440 450 460 470
590 600 610 620 630 640
pF1KA0 FSPDDLRKHGLDGAIISTFLKMGILQEH-PIPLSYSFIHLCFQEFFAAMSYVL-EDEKGR
: .::::::::: .:.::.:.:.:. :::::: :::::::: :.: : : :
CCDS12 FEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGA
480 490 500 510 520 530
650 660 670 680 690 700
pF1KA0 GKHSNCIIDLEKTLEAYGI-HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNL
: . :. . : :.. . : : :.:::.:::..: . ..:. . ..: .:
CCDS12 GPDQ----DVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDL
540 550 560 570 580 590
710 720 730 740 750
pF1KA0 MQWVPSLQL----LLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMC-VETDMELLVCT
.::. : :: ::: . :::: ... :. :...::. . . . . :: .: .
CCDS12 LQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSS
600 610 620 630 640 650
760 770 780 790 800
pF1KA0 FCIKFSRHVKKLQLI--------EGRQHRSTWSPTMVV-LFRWVPVTDAYWQILFSVLKV
::.: : .. :.: : : . :. . :..: : . . . ::: . : ..: .
CCDS12 FCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCT
660 670 680 690 700 710
810 820 830 840 850 860
pF1KA0 TRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQT
. :: ::.: :.:. .:: ::. ::.: : :..::: : ... :.::. .: ::..
CCDS12 NPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKN
720 730 740 750 760 770
870 880 890 900 910 920
pF1KA0 LTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKE
::..::: : . : ::. ::.:.:.:: .:: .: : : ::..::::...: : :
CCDS12 LTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVE
780 790 800 810 820 830
930 940 950 960 970 980
pF1KA0 LDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS----DEMRQELRALEQEKPQLL
::: : :.:.:.::::.:::::.:.: : : :. ::. . : . .. . :
CCDS12 LDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDL
840 850 860 870 880 890
990 1000 1010 1020 1030
pF1KA0 IFSRRKP-SVMTPTEGLDTGEMSNSTSSLKRQRLGSE--RAASHVAQAN--LKLLDVSKI
... .:. ::: . .: : :::: .. : : ::: :. ::.:
CCDS12 SLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFN
900 910 920 930 940 950
1040 1050 1060 1070 1080 1090
pF1KA0 FPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNL
CCDS12 DLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALG
960 970 980 990 1000 1010
>>CCDS62785.1 NLRP12 gene_id:91662|Hs108|chr19 (1062 aa)
initn: 2262 init1: 544 opt: 1095 Z-score: 914.3 bits: 181.3 E(32554): 1.3e-44
Smith-Waterman score: 1722; 40.2% identity (65.6% similar) in 809 aa overlap (273-1035:152-950)
250 260 270 280 290 300
pF1KA0 QAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPD
......:.:::. . : ..:. . .
CCDS62 RKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLV-KEH---SNPM--QVQQQ
130 140 150 160 170
310 320 330 340 350
pF1KA0 YVEENRGHL---------IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWG
.. .::: :.:. :: : . :: : :..::::::::: ::..: :.
CCDS62 LLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWA
180 190 200 210 220 230
360 370 380 390 400 410
pF1KA0 RGQLYGDRFQHVFYFSCRELAQSKV-VSLAELIGKDGTATPAPIRQILSRPERLLFILDG
:.:. ::...::..:::. :: . :. .:: . ::..... :::::::.::
CCDS62 DGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDG
240 250 260 270 280 290
420 430 440 450 460 470
pF1KA0 VDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLE
:: ...:.. :: : . .:.. ::.::. : .::: :.:::.: :::..: ::
CCDS62 FDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLE
300 310 320 330 340 350
480 490 500 510 520 530
pF1KA0 QARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLM
. : ::.:::::. ::::::.:: . .:: ..: :..:. :...:.:: : :..::::.
CCDS62 HPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQ
360 370 380 390 400 410
540 550 560 570 580
pF1KA0 QQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGPQL------RDLCSLAAEGIWQKKTL
::.. : ::.:::.. . :: . .: .: .:.: : ::::::.:.:..: :
CCDS62 QQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKIL
420 430 440 450 460 470
590 600 610 620 630 640
pF1KA0 FSPDDLRKHGLDGAIISTFLKMGILQEH-PIPLSYSFIHLCFQEFFAAMSYVL-EDEKGR
: .::::::::: .:.::.:.:.:. :::::: :::::::: :.: : : :
CCDS62 FEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGA
480 490 500 510 520 530
650 660 670 680 690 700
pF1KA0 GKHSNCIIDLEKTLEAYGI-HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNL
: . :. . : :.. . : : :.:::.:::..: . ..:. . ..: .:
CCDS62 GPDQ----DVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDL
540 550 560 570 580 590
710 720 730 740 750
pF1KA0 MQWVPSLQL----LLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMC-VETDMELLVCT
.::. : :: ::: . :::: ... :. :...::. . . . . :: .: .
CCDS62 LQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSS
600 610 620 630 640 650
760 770 780 790 800
pF1KA0 FCIKFSRHVKKLQLI--------EGRQHRSTWSPTMVVLFR--WVPVTDAYWQILFSVLK
::.: : .. :.: : : . :. . :..: .: . . ::: . : ..:
CCDS62 FCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLRPERTVLLDAYSEHLAAALC
660 670 680 690 700 710
810 820 830 840 850 860
pF1KA0 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ
.. :: ::.: :.:. .:: ::. ::.: : :..::: : ... :.::. .: ::.
CCDS62 TNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANK
720 730 740 750 760 770
870 880 890 900 910 920
pF1KA0 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK
.::..::: : . : ::. ::.:.:.:: .:: .: : : ::..::::...: :
CCDS62 NLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLV
780 790 800 810 820 830
930 940 950 960 970 980
pF1KA0 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS----DEMRQELRALEQEKPQL
:::: : :.:.:.::::.:::::.:.: : : :. ::. . : . .. .
CCDS62 ELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELD
840 850 860 870 880 890
990 1000 1010 1020 1030
pF1KA0 LIFSRRKP-SVMTPTEGLDTGEMSNSTSSLKRQRLGSE--RAASHVAQAN--LKLLDVSK
: ... .:. ::: . .: : :::: .. : : ::: :. ::.:
CCDS62 LSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSF
900 910 920 930 940 950
1040 1050 1060 1070 1080 1090
pF1KA0 IFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKN
CCDS62 NDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNAL
960 970 980 990 1000 1010
>>CCDS1633.1 NLRP3 gene_id:114548|Hs108|chr1 (922 aa)
initn: 1833 init1: 689 opt: 976 Z-score: 816.3 bits: 162.9 E(32554): 3.8e-39
Smith-Waterman score: 1564; 38.3% identity (66.8% similar) in 754 aa overlap (274-983:164-916)
250 260 270 280 290 300
pF1KA0 AHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQ--RPHPRSQDPLVKRSWP
.:...:.: :.. : . . .. :. .
CCDS16 KDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKT
140 150 160 170 180 190
310 320 330 340 350 360
pF1KA0 DYVEENRGHLIEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
: . :... :: : . .:: . :..::::::::. :::.. :. : :: ::
CCDS16 KTCESPVSP-IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR
200 210 220 230 240 250
370 380 390 400 410 420
pF1KA0 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
:...::. :::.. ::..:: . ::..:. .: :.::..:: :: ...
CCDS16 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD
260 270 280 290 300 310
430 440 450 460 470 480
pF1KA0 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
: . :: :.. . .: ::.::. : .:::::.:::.: .::..: :.. : ::.::
CCDS16 EHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILG
320 330 340 350 360 370
490 500 510 520 530 540
pF1KA0 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
:::..:::::..::.:: :: :: :.. :. :...:..: : :..:: : :::. ..:
CCDS16 FSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSL
380 390 400 410 420 430
550 560 570 580 590
pF1KA0 TLTSKTTTTLCLHYLAQALQ----AQPLG--PQLRDLCSLAAEGIWQKKTLFSPDDLRKH
. ::::::.. . .:.. :: .: : .: ::::::.:::..: :: .:::.:
CCDS16 AQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNH
440 450 460 470 480 490
600 610 620 630 640 650
pF1KA0 GLDGAIISTFLKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-
::. : .:.::.:...: : :::::. :::::::: :.::.:: :: . . .
CCDS16 GLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLK
500 510 520 530 540 550
660 670 680 690 700
pF1KA0 ----DLEKTLEAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG-R-NLMQWV
:. :: :: .. . ..:::.::...: .:. . :..:: : .:..:.
CCDS16 LPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWI
560 570 580 590 600 610
710 720 730 740 750 760
pF1KA0 P----SLQLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKF
. .: .:: .:: ..:::: ... :. ..: .: .. . . : :. .: .:::.
CCDS16 EVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIEN
620 630 640 650 660 670
770 780 790 800
pF1KA0 SRHVKKLQL--------------IEGRQHRSTW----SPTMVVLFRWVPVTDAYWQILFS
..:..:.: :::. . : . .. . . . :.
CCDS16 CHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFD
680 690 700 710 720 730
810 820 830 840 850
pF1KA0 ---VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF
::. ...: ::::: :.:. ... :: :.. : :. : :.. :::. :. :.
CCDS16 ISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSS
740 750 760 770 780 790
860 870 880 890 900 910
pF1KA0 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS
: .::.::.: : :.: : : : ::. : .:.:::: :.: .:.::: :: ::...:.
CCDS16 VLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLT
800 810 820 830 840 850
920 930 940 950 960 970
pF1KA0 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP
.: ::..:.: .:.: :.:: ..:: :.. .: : :::.. .. : .. :..:..:::
CCDS16 SSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKP
860 870 880 890 900 910
980 990 1000 1010 1020 1030
pF1KA0 QLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFP
.: .
CCDS16 ELTVVFEPSW
920
>>CCDS44346.1 NLRP3 gene_id:114548|Hs108|chr1 (979 aa)
initn: 1965 init1: 689 opt: 976 Z-score: 815.9 bits: 163.0 E(32554): 4e-39
Smith-Waterman score: 1605; 39.6% identity (67.7% similar) in 745 aa overlap (274-974:164-907)
250 260 270 280 290 300
pF1KA0 AHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQ--RPHPRSQDPLVKRSWP
.:...:.: :.. : . . .. :. .
CCDS44 KDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKT
140 150 160 170 180 190
310 320 330 340 350 360
pF1KA0 DYVEENRGHLIEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
: . :... :: : . .:: . :..::::::::. :::.. :. : :: ::
CCDS44 KTCESPVSP-IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR
200 210 220 230 240 250
370 380 390 400 410 420
pF1KA0 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
:...::. :::.. ::..:: . ::..:. .: :.::..:: :: ...
CCDS44 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD
260 270 280 290 300 310
430 440 450 460 470 480
pF1KA0 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
: . :: :.. . .: ::.::. : .:::::.:::.: .::..: :.. : ::.::
CCDS44 EHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILG
320 330 340 350 360 370
490 500 510 520 530 540
pF1KA0 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
:::..:::::..::.:: :: :: :.. :. :...:..: : :..:: : :::. ..:
CCDS44 FSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSL
380 390 400 410 420 430
550 560 570 580 590
pF1KA0 TLTSKTTTTLCLHYLAQALQ----AQPLG--PQLRDLCSLAAEGIWQKKTLFSPDDLRKH
. ::::::.. . .:.. :: .: : .: ::::::.:::..: :: .:::.:
CCDS44 AQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNH
440 450 460 470 480 490
600 610 620 630 640 650
pF1KA0 GLDGAIISTFLKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-
::. : .:.::.:...: : :::::. :::::::: :.::.:: :: . . .
CCDS44 GLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLK
500 510 520 530 540 550
660 670 680 690 700
pF1KA0 ----DLEKTLEAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG-R-NLMQWV
:. :: :: .. . ..:::.::...: .:. . :..:: : .:..:.
CCDS44 LPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWI
560 570 580 590 600 610
710 720 730 740 750 760
pF1KA0 P----SLQLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKF
. .: .:: .:: ..:::: ... :. ..: .: .. . . : :. .: .:::.
CCDS44 EVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIEN
620 630 640 650 660 670
770 780 790
pF1KA0 SRHVKKLQL--------------IEGRQHRSTW----SPTMVVLFRWV---PVTDAYWQI
..:..:.: :::. . : . .. . . .:... .
CCDS44 CHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRG
680 690 700 710 720 730
800 810 820 830 840 850
pF1KA0 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF
:::::.....: ::::: :::. ... ::.::..: : .. : :. :::. : : :...
CCDS44 LFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISL
740 750 760 770 780 790
860 870 880 890 900 910
pF1KA0 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS
: .:: :.::::: :.: : : . :: :.. :.:..: ::. :::: ::. :.::::
CCDS44 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLS
800 810 820 830 840 850
920 930 940 950 960 970
pF1KA0 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP
.. .: .: :. :.: : :..:::::: :: ::: : ::. .:... .: .:
CCDS44 TNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQ
860 870 880 890 900 910
980 990 1000 1010 1020 1030
pF1KA0 QLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFP
CCDS44 SLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELT
920 930 940 950 960 970
1429 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 19:59:22 2016 done: Wed Nov 2 19:59:23 2016
Total Scan time: 3.830 Total Display time: 0.540
Function used was FASTA [36.3.4 Apr, 2011]