Result of FASTA (omim) for
pF1KA0926
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0926, 1429 aa
1>>>pF1KA0926 1429 - 1429 aa - 1429 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.2880+/-0.000412; mu= 8.7563+/- 0.026
mean_var=160.3388+/-32.641, 0's: 0 Z-trim(116.0): 206 B-trim: 13 in 1/56
Lambda= 0.101287
statistics sampled from 26590 (26808) to 26590 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.659), E-opt: 0.2 (0.314), width: 16
Scan time: 11.260
The best scores are: opt bits E(85289)
NP_055737 (OMIM: 606579,606636,615225) NACHT, LRR (1429) 9701 1431.0 0
NP_127497 (OMIM: 606579,606636,615225) NACHT, LRR (1473) 8583 1267.6 0
NP_001028225 (OMIM: 606579,606636,615225) NACHT, L (1375) 8565 1265.0 0
NP_127500 (OMIM: 606579,606636,615225) NACHT, LRR (1399) 6545 969.8 0
NP_127499 (OMIM: 606579,606636,615225) NACHT, LRR (1443) 6545 969.8 0
XP_016882955 (OMIM: 609648,611762) PREDICTED: NACH ( 923) 1095 173.3 7.7e-42
XP_016882956 (OMIM: 609648,611762) PREDICTED: NACH ( 923) 1095 173.3 7.7e-42
XP_016882953 (OMIM: 609648,611762) PREDICTED: NACH ( 923) 1095 173.3 7.7e-42
XP_016882954 (OMIM: 609648,611762) PREDICTED: NACH ( 923) 1095 173.3 7.7e-42
XP_016882952 (OMIM: 609648,611762) PREDICTED: NACH ( 923) 1095 173.3 7.7e-42
XP_011525784 (OMIM: 609648,611762) PREDICTED: NACH ( 948) 1095 173.3 7.8e-42
NP_001264058 (OMIM: 609648,611762) NACHT, LRR and (1004) 1095 173.3 8.2e-42
XP_016882951 (OMIM: 609648,611762) PREDICTED: NACH (1004) 1095 173.3 8.2e-42
XP_011525782 (OMIM: 609648,611762) PREDICTED: NACH (1005) 1095 173.3 8.2e-42
XP_011525781 (OMIM: 609648,611762) PREDICTED: NACH (1005) 1095 173.3 8.2e-42
XP_016882950 (OMIM: 609648,611762) PREDICTED: NACH (1005) 1095 173.3 8.2e-42
NP_653288 (OMIM: 609648,611762) NACHT, LRR and PYD (1061) 1095 173.3 8.6e-42
XP_016882949 (OMIM: 609648,611762) PREDICTED: NACH (1061) 1095 173.3 8.6e-42
NP_001264055 (OMIM: 609648,611762) NACHT, LRR and (1062) 1095 173.3 8.6e-42
XP_011542357 (OMIM: 120100,191900,606416,607115) P ( 865) 976 155.9 1.2e-36
NP_899632 (OMIM: 120100,191900,606416,607115) NACH ( 922) 976 155.9 1.3e-36
XP_011542355 (OMIM: 120100,191900,606416,607115) P ( 922) 976 155.9 1.3e-36
XP_016855673 (OMIM: 120100,191900,606416,607115) P ( 922) 976 155.9 1.3e-36
XP_016855672 (OMIM: 120100,191900,606416,607115) P ( 979) 976 155.9 1.4e-36
NP_001120934 (OMIM: 120100,191900,606416,607115) N ( 979) 976 155.9 1.4e-36
NP_001120933 (OMIM: 120100,191900,606416,607115) N ( 979) 976 155.9 1.4e-36
NP_001230062 (OMIM: 120100,191900,606416,607115) N (1034) 976 155.9 1.4e-36
XP_011542350 (OMIM: 120100,191900,606416,607115) P (1036) 976 155.9 1.4e-36
XP_016855671 (OMIM: 120100,191900,606416,607115) P (1036) 976 155.9 1.4e-36
XP_016855670 (OMIM: 120100,191900,606416,607115) P (1036) 976 155.9 1.4e-36
NP_001073289 (OMIM: 120100,191900,606416,607115) N (1036) 976 155.9 1.4e-36
NP_004886 (OMIM: 120100,191900,606416,607115) NACH (1036) 976 155.9 1.4e-36
NP_631915 (OMIM: 231090,609661) NACHT, LRR and PYD (1009) 954 152.7 1.3e-35
XP_016881833 (OMIM: 609645) PREDICTED: NACHT, LRR ( 938) 915 147.0 6.4e-34
XP_011518346 (OMIM: 609665) PREDICTED: NACHT, LRR (1052) 896 144.2 4.9e-33
NP_789792 (OMIM: 609665) NACHT, LRR and PYD domain (1093) 896 144.3 5e-33
XP_016881834 (OMIM: 609645) PREDICTED: NACHT, LRR ( 937) 879 141.7 2.5e-32
NP_604393 (OMIM: 609645) NACHT, LRR and PYD domain ( 994) 879 141.7 2.6e-32
XP_011518233 (OMIM: 609650) PREDICTED: NACHT, LRR ( 703) 817 132.6 1e-29
XP_016872741 (OMIM: 609650) PREDICTED: NACHT, LRR ( 771) 817 132.6 1.1e-29
NP_001263629 (OMIM: 609650) NACHT, LRR and PYD dom ( 891) 817 132.7 1.3e-29
NP_612202 (OMIM: 609650) NACHT, LRR and PYD domain ( 892) 817 132.7 1.3e-29
XP_016872742 (OMIM: 609650) PREDICTED: NACHT, LRR ( 730) 807 131.2 2.9e-29
NP_996611 (OMIM: 231090,609661) NACHT, LRR and PYD ( 980) 798 129.9 9.4e-29
XP_011524903 (OMIM: 231090,609661) PREDICTED: NACH (1008) 798 129.9 9.6e-29
XP_006723139 (OMIM: 231090,609661) PREDICTED: NACH (1037) 798 129.9 9.8e-29
XP_011524901 (OMIM: 231090,609661) PREDICTED: NACH (1037) 798 129.9 9.8e-29
NP_001120727 (OMIM: 231090,609661) NACHT, LRR and (1037) 798 129.9 9.8e-29
XP_006723138 (OMIM: 231090,609661) PREDICTED: NACH (1037) 798 129.9 9.8e-29
XP_011524898 (OMIM: 231090,609661) PREDICTED: NACH (1065) 798 129.9 1e-28
>>NP_055737 (OMIM: 606579,606636,615225) NACHT, LRR and (1429 aa)
initn: 9701 init1: 9701 opt: 9701 Z-score: 7665.8 bits: 1431.0 E(85289): 0
Smith-Waterman score: 9701; 100.0% identity (100.0% similar) in 1429 aa overlap (1-1429:1-1429)
10 20 30 40 50 60
pF1KA0 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 KELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPP
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 ARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPS
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420
pF1KA0 QMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
1390 1400 1410 1420
>>NP_127497 (OMIM: 606579,606636,615225) NACHT, LRR and (1473 aa)
initn: 9024 init1: 8583 opt: 8583 Z-score: 6782.6 bits: 1267.6 E(85289): 0
Smith-Waterman score: 9529; 97.0% identity (97.0% similar) in 1461 aa overlap (1-1417:1-1461)
10 20 30 40 50 60
pF1KA0 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
1210 1220 1230 1240 1250 1260
1270
pF1KA0 K--------------------------------------------ELELCYRSPGEDQLF
: :::::::::::::::
NP_127 KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KA0 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KA0 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC
1390 1400 1410 1420 1430 1440
1400 1410 1420
pF1KA0 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
:::::::::::::::::::::
NP_127 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
1450 1460 1470
>>NP_001028225 (OMIM: 606579,606636,615225) NACHT, LRR a (1375 aa)
initn: 9023 init1: 7094 opt: 8565 Z-score: 6768.9 bits: 1265.0 E(85289): 0
Smith-Waterman score: 8791; 96.5% identity (96.5% similar) in 1357 aa overlap (1-1309:1-1357)
10 20 30 40 50 60
pF1KA0 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070
pF1KA0 ASHVAQANLKLLDVSKIFPIAEIA----EESSPEVVPVELLCVPSPASQGDLHTKPLGTD
:::::::::::::::::::::::: ::::::::::::::::::::::::::::::::
NP_001 ASHVAQANLKLLDVSKIFPIAEIAGKSHEESSPEVVPVELLCVPSPASQGDLHTKPLGTD
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KA0 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KA0 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KA0 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD
1210 1220 1230 1240 1250 1260
1260 1270
pF1KA0 CSIRK--------------------------------------------ELELCYRSPGE
::::: :::::::::::
NP_001 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KA0 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAP
:::::::::::::::::::::::::::::::::::::
NP_001 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGRNTSQPWNLRCNRDARRY
1330 1340 1350 1360 1370
1340 1350 1360 1370 1380 1390
pF1KA0 QLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSW
>>NP_127500 (OMIM: 606579,606636,615225) NACHT, LRR and (1399 aa)
initn: 9500 init1: 6545 opt: 6545 Z-score: 5173.5 bits: 969.8 E(85289): 0
Smith-Waterman score: 9444; 97.9% identity (97.9% similar) in 1429 aa overlap (1-1429:1-1399)
10 20 30 40 50 60
pF1KA0 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG---
910 920 930 940 950
970 980 990 1000 1010 1020
pF1KA0 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
:::::::::::::::::::::::::::::::::
NP_127 ---------------------------KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KA0 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KA0 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190 1200
pF1KA0 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
1120 1130 1140 1150 1160 1170
1210 1220 1230 1240 1250 1260
pF1KA0 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
1180 1190 1200 1210 1220 1230
1270 1280 1290 1300 1310 1320
pF1KA0 KELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 KELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPP
1240 1250 1260 1270 1280 1290
1330 1340 1350 1360 1370 1380
pF1KA0 ARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 ARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPS
1300 1310 1320 1330 1340 1350
1390 1400 1410 1420
pF1KA0 QMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 QMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
1360 1370 1380 1390
>>NP_127499 (OMIM: 606579,606636,615225) NACHT, LRR and (1443 aa)
initn: 8382 init1: 6545 opt: 6545 Z-score: 5173.3 bits: 969.8 E(85289): 0
Smith-Waterman score: 9346; 95.0% identity (95.0% similar) in 1473 aa overlap (1-1429:1-1443)
10 20 30 40 50 60
pF1KA0 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG---
910 920 930 940 950
970 980 990 1000 1010 1020
pF1KA0 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
:::::::::::::::::::::::::::::::::
NP_127 ---------------------------KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KA0 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KA0 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190 1200
pF1KA0 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
1120 1130 1140 1150 1160 1170
1210 1220 1230 1240 1250 1260
pF1KA0 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
1180 1190 1200 1210 1220 1230
1270
pF1KA0 K--------------------------------------------ELELCYRSPGEDQLF
: :::::::::::::::
NP_127 KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF
1240 1250 1260 1270 1280 1290
1280 1290 1300 1310 1320 1330
pF1KA0 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH
1300 1310 1320 1330 1340 1350
1340 1350 1360 1370 1380 1390
pF1KA0 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC
1360 1370 1380 1390 1400 1410
1400 1410 1420
pF1KA0 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
:::::::::::::::::::::::::::::::::
NP_127 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
1420 1430 1440
>>XP_016882955 (OMIM: 609648,611762) PREDICTED: NACHT, L (923 aa)
initn: 2262 init1: 544 opt: 1095 Z-score: 872.2 bits: 173.3 E(85289): 7.7e-42
Smith-Waterman score: 1722; 40.2% identity (65.6% similar) in 809 aa overlap (273-1035:13-811)
250 260 270 280 290 300
pF1KA0 QAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPD
......:.:::. . : ..:. . .
XP_016 MEDRNARLGECVNLSHRYTRLLLV-KEH---SNPM--QVQQQ
10 20 30
310 320 330 340 350
pF1KA0 YVEENRGHL---------IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWG
.. .::: :.:. :: : . :: : :..::::::::: ::..: :.
XP_016 LLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWA
40 50 60 70 80 90
360 370 380 390 400 410
pF1KA0 RGQLYGDRFQHVFYFSCRELAQSKV-VSLAELIGKDGTATPAPIRQILSRPERLLFILDG
:.:. ::...::..:::. :: . :. .:: . ::..... :::::::.::
XP_016 DGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDG
100 110 120 130 140 150
420 430 440 450 460 470
pF1KA0 VDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLE
:: ...:.. :: : . .:.. ::.::. : .::: :.:::.: :::..: ::
XP_016 FDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLE
160 170 180 190 200 210
480 490 500 510 520 530
pF1KA0 QARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLM
. : ::.:::::. ::::::.:: . .:: ..: :..:. :...:.:: : :..::::.
XP_016 HPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQ
220 230 240 250 260 270
540 550 560 570 580
pF1KA0 QQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGPQL------RDLCSLAAEGIWQKKTL
::.. : ::.:::.. . :: . .: .: .:.: : ::::::.:.:..: :
XP_016 QQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKIL
280 290 300 310 320 330
590 600 610 620 630 640
pF1KA0 FSPDDLRKHGLDGAIISTFLKMGILQEH-PIPLSYSFIHLCFQEFFAAMSYVL-EDEKGR
: .::::::::: .:.::.:.:.:. :::::: :::::::: :.: : : :
XP_016 FEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGA
340 350 360 370 380 390
650 660 670 680 690 700
pF1KA0 GKHSNCIIDLEKTLEAYGI-HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNL
: . :. . : :.. . : : :.:::.:::..: . ..:. . ..: .:
XP_016 GPDQ----DVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDL
400 410 420 430 440 450
710 720 730 740 750
pF1KA0 MQWVPSLQL----LLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMC-VETDMELLVCT
.::. : :: ::: . :::: ... :. :...::. . . . . :: .: .
XP_016 LQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSS
460 470 480 490 500 510
760 770 780 790 800
pF1KA0 FCIKFSRHVKKLQLI--------EGRQHRSTWSPTMVVLFR--WVPVTDAYWQILFSVLK
::.: : .. :.: : : . :. . :..: .: . . ::: . : ..:
XP_016 FCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLRPERTVLLDAYSEHLAAALC
520 530 540 550 560 570
810 820 830 840 850 860
pF1KA0 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ
.. :: ::.: :.:. .:: ::. ::.: : :..::: : ... :.::. .: ::.
XP_016 TNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANK
580 590 600 610 620 630
870 880 890 900 910 920
pF1KA0 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK
.::..::: : . : ::. ::.:.:.:: .:: .: : : ::..::::...: :
XP_016 NLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLV
640 650 660 670 680 690
930 940 950 960 970 980
pF1KA0 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS----DEMRQELRALEQEKPQL
:::: : :.:.:.::::.:::::.:.: : : :. ::. . : . .. .
XP_016 ELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELD
700 710 720 730 740 750
990 1000 1010 1020 1030
pF1KA0 LIFSRRKP-SVMTPTEGLDTGEMSNSTSSLKRQRLGSE--RAASHVAQAN--LKLLDVSK
: ... .:. ::: . .: : :::: .. : : ::: :. ::.:
XP_016 LSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSF
760 770 780 790 800 810
1040 1050 1060 1070 1080 1090
pF1KA0 IFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKN
XP_016 NDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNAL
820 830 840 850 860 870
>--
initn: 519 init1: 276 opt: 276 Z-score: 225.4 bits: 53.6 E(85289): 8.1e-06
Smith-Waterman score: 276; 44.5% identity (65.5% similar) in 110 aa overlap (874-983:812-921)
850 860 870 880 890 900
pF1KA0 LAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVS
:: : : : : . :..:.:.::.: : :
XP_016 LGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDS
790 800 810 820 830 840
910 920 930 940 950 960
pF1KA0 CGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTL
::::. :..: .:. . .: .: : .: : :.::::::. : ::.::: : : :
XP_016 CGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDL
850 860 870 880 890 900
970 980 990 1000 1010 1020
pF1KA0 SDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERAASH
. ...: ::. :: : :
XP_016 NKMTHSRLAALRVTKPYLDIGC
910 920
>>XP_016882956 (OMIM: 609648,611762) PREDICTED: NACHT, L (923 aa)
initn: 2262 init1: 544 opt: 1095 Z-score: 872.2 bits: 173.3 E(85289): 7.7e-42
Smith-Waterman score: 1722; 40.2% identity (65.6% similar) in 809 aa overlap (273-1035:13-811)
250 260 270 280 290 300
pF1KA0 QAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPD
......:.:::. . : ..:. . .
XP_016 MEDRNARLGECVNLSHRYTRLLLV-KEH---SNPM--QVQQQ
10 20 30
310 320 330 340 350
pF1KA0 YVEENRGHL---------IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWG
.. .::: :.:. :: : . :: : :..::::::::: ::..: :.
XP_016 LLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWA
40 50 60 70 80 90
360 370 380 390 400 410
pF1KA0 RGQLYGDRFQHVFYFSCRELAQSKV-VSLAELIGKDGTATPAPIRQILSRPERLLFILDG
:.:. ::...::..:::. :: . :. .:: . ::..... :::::::.::
XP_016 DGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDG
100 110 120 130 140 150
420 430 440 450 460 470
pF1KA0 VDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLE
:: ...:.. :: : . .:.. ::.::. : .::: :.:::.: :::..: ::
XP_016 FDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLE
160 170 180 190 200 210
480 490 500 510 520 530
pF1KA0 QARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLM
. : ::.:::::. ::::::.:: . .:: ..: :..:. :...:.:: : :..::::.
XP_016 HPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQ
220 230 240 250 260 270
540 550 560 570 580
pF1KA0 QQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGPQL------RDLCSLAAEGIWQKKTL
::.. : ::.:::.. . :: . .: .: .:.: : ::::::.:.:..: :
XP_016 QQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKIL
280 290 300 310 320 330
590 600 610 620 630 640
pF1KA0 FSPDDLRKHGLDGAIISTFLKMGILQEH-PIPLSYSFIHLCFQEFFAAMSYVL-EDEKGR
: .::::::::: .:.::.:.:.:. :::::: :::::::: :.: : : :
XP_016 FEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGA
340 350 360 370 380 390
650 660 670 680 690 700
pF1KA0 GKHSNCIIDLEKTLEAYGI-HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNL
: . :. . : :.. . : : :.:::.:::..: . ..:. . ..: .:
XP_016 GPDQ----DVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDL
400 410 420 430 440 450
710 720 730 740 750
pF1KA0 MQWVPSLQL----LLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMC-VETDMELLVCT
.::. : :: ::: . :::: ... :. :...::. . . . . :: .: .
XP_016 LQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSS
460 470 480 490 500 510
760 770 780 790 800
pF1KA0 FCIKFSRHVKKLQLI--------EGRQHRSTWSPTMVVLFR--WVPVTDAYWQILFSVLK
::.: : .. :.: : : . :. . :..: .: . . ::: . : ..:
XP_016 FCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLRPERTVLLDAYSEHLAAALC
520 530 540 550 560 570
810 820 830 840 850 860
pF1KA0 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ
.. :: ::.: :.:. .:: ::. ::.: : :..::: : ... :.::. .: ::.
XP_016 TNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANK
580 590 600 610 620 630
870 880 890 900 910 920
pF1KA0 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK
.::..::: : . : ::. ::.:.:.:: .:: .: : : ::..::::...: :
XP_016 NLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLV
640 650 660 670 680 690
930 940 950 960 970 980
pF1KA0 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS----DEMRQELRALEQEKPQL
:::: : :.:.:.::::.:::::.:.: : : :. ::. . : . .. .
XP_016 ELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELD
700 710 720 730 740 750
990 1000 1010 1020 1030
pF1KA0 LIFSRRKP-SVMTPTEGLDTGEMSNSTSSLKRQRLGSE--RAASHVAQAN--LKLLDVSK
: ... .:. ::: . .: : :::: .. : : ::: :. ::.:
XP_016 LSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSF
760 770 780 790 800 810
1040 1050 1060 1070 1080 1090
pF1KA0 IFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKN
XP_016 NDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNAL
820 830 840 850 860 870
>--
initn: 519 init1: 276 opt: 276 Z-score: 225.4 bits: 53.6 E(85289): 8.1e-06
Smith-Waterman score: 276; 44.5% identity (65.5% similar) in 110 aa overlap (874-983:812-921)
850 860 870 880 890 900
pF1KA0 LAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVS
:: : : : : . :..:.:.::.: : :
XP_016 LGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDS
790 800 810 820 830 840
910 920 930 940 950 960
pF1KA0 CGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTL
::::. :..: .:. . .: .: : .: : :.::::::. : ::.::: : : :
XP_016 CGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDL
850 860 870 880 890 900
970 980 990 1000 1010 1020
pF1KA0 SDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERAASH
. ...: ::. :: : :
XP_016 NKMTHSRLAALRVTKPYLDIGC
910 920
>>XP_016882953 (OMIM: 609648,611762) PREDICTED: NACHT, L (923 aa)
initn: 2262 init1: 544 opt: 1095 Z-score: 872.2 bits: 173.3 E(85289): 7.7e-42
Smith-Waterman score: 1722; 40.2% identity (65.6% similar) in 809 aa overlap (273-1035:13-811)
250 260 270 280 290 300
pF1KA0 QAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPD
......:.:::. . : ..:. . .
XP_016 MEDRNARLGECVNLSHRYTRLLLV-KEH---SNPM--QVQQQ
10 20 30
310 320 330 340 350
pF1KA0 YVEENRGHL---------IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWG
.. .::: :.:. :: : . :: : :..::::::::: ::..: :.
XP_016 LLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWA
40 50 60 70 80 90
360 370 380 390 400 410
pF1KA0 RGQLYGDRFQHVFYFSCRELAQSKV-VSLAELIGKDGTATPAPIRQILSRPERLLFILDG
:.:. ::...::..:::. :: . :. .:: . ::..... :::::::.::
XP_016 DGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDG
100 110 120 130 140 150
420 430 440 450 460 470
pF1KA0 VDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLE
:: ...:.. :: : . .:.. ::.::. : .::: :.:::.: :::..: ::
XP_016 FDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLE
160 170 180 190 200 210
480 490 500 510 520 530
pF1KA0 QARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLM
. : ::.:::::. ::::::.:: . .:: ..: :..:. :...:.:: : :..::::.
XP_016 HPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQ
220 230 240 250 260 270
540 550 560 570 580
pF1KA0 QQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGPQL------RDLCSLAAEGIWQKKTL
::.. : ::.:::.. . :: . .: .: .:.: : ::::::.:.:..: :
XP_016 QQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKIL
280 290 300 310 320 330
590 600 610 620 630 640
pF1KA0 FSPDDLRKHGLDGAIISTFLKMGILQEH-PIPLSYSFIHLCFQEFFAAMSYVL-EDEKGR
: .::::::::: .:.::.:.:.:. :::::: :::::::: :.: : : :
XP_016 FEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGA
340 350 360 370 380 390
650 660 670 680 690 700
pF1KA0 GKHSNCIIDLEKTLEAYGI-HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNL
: . :. . : :.. . : : :.:::.:::..: . ..:. . ..: .:
XP_016 GPDQ----DVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDL
400 410 420 430 440 450
710 720 730 740 750
pF1KA0 MQWVPSLQL----LLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMC-VETDMELLVCT
.::. : :: ::: . :::: ... :. :...::. . . . . :: .: .
XP_016 LQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSS
460 470 480 490 500 510
760 770 780 790 800
pF1KA0 FCIKFSRHVKKLQLI--------EGRQHRSTWSPTMVVLFR--WVPVTDAYWQILFSVLK
::.: : .. :.: : : . :. . :..: .: . . ::: . : ..:
XP_016 FCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLRPERTVLLDAYSEHLAAALC
520 530 540 550 560 570
810 820 830 840 850 860
pF1KA0 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ
.. :: ::.: :.:. .:: ::. ::.: : :..::: : ... :.::. .: ::.
XP_016 TNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANK
580 590 600 610 620 630
870 880 890 900 910 920
pF1KA0 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK
.::..::: : . : ::. ::.:.:.:: .:: .: : : ::..::::...: :
XP_016 NLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLV
640 650 660 670 680 690
930 940 950 960 970 980
pF1KA0 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS----DEMRQELRALEQEKPQL
:::: : :.:.:.::::.:::::.:.: : : :. ::. . : . .. .
XP_016 ELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELD
700 710 720 730 740 750
990 1000 1010 1020 1030
pF1KA0 LIFSRRKP-SVMTPTEGLDTGEMSNSTSSLKRQRLGSE--RAASHVAQAN--LKLLDVSK
: ... .:. ::: . .: : :::: .. : : ::: :. ::.:
XP_016 LSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSF
760 770 780 790 800 810
1040 1050 1060 1070 1080 1090
pF1KA0 IFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKN
XP_016 NDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNAL
820 830 840 850 860 870
>--
initn: 519 init1: 276 opt: 276 Z-score: 225.4 bits: 53.6 E(85289): 8.1e-06
Smith-Waterman score: 276; 44.5% identity (65.5% similar) in 110 aa overlap (874-983:812-921)
850 860 870 880 890 900
pF1KA0 LAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVS
:: : : : : . :..:.:.::.: : :
XP_016 LGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDS
790 800 810 820 830 840
910 920 930 940 950 960
pF1KA0 CGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTL
::::. :..: .:. . .: .: : .: : :.::::::. : ::.::: : : :
XP_016 CGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDL
850 860 870 880 890 900
970 980 990 1000 1010 1020
pF1KA0 SDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERAASH
. ...: ::. :: : :
XP_016 NKMTHSRLAALRVTKPYLDIGC
910 920
>>XP_016882954 (OMIM: 609648,611762) PREDICTED: NACHT, L (923 aa)
initn: 2262 init1: 544 opt: 1095 Z-score: 872.2 bits: 173.3 E(85289): 7.7e-42
Smith-Waterman score: 1722; 40.2% identity (65.6% similar) in 809 aa overlap (273-1035:13-811)
250 260 270 280 290 300
pF1KA0 QAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPD
......:.:::. . : ..:. . .
XP_016 MEDRNARLGECVNLSHRYTRLLLV-KEH---SNPM--QVQQQ
10 20 30
310 320 330 340 350
pF1KA0 YVEENRGHL---------IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWG
.. .::: :.:. :: : . :: : :..::::::::: ::..: :.
XP_016 LLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWA
40 50 60 70 80 90
360 370 380 390 400 410
pF1KA0 RGQLYGDRFQHVFYFSCRELAQSKV-VSLAELIGKDGTATPAPIRQILSRPERLLFILDG
:.:. ::...::..:::. :: . :. .:: . ::..... :::::::.::
XP_016 DGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDG
100 110 120 130 140 150
420 430 440 450 460 470
pF1KA0 VDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLE
:: ...:.. :: : . .:.. ::.::. : .::: :.:::.: :::..: ::
XP_016 FDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLE
160 170 180 190 200 210
480 490 500 510 520 530
pF1KA0 QARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLM
. : ::.:::::. ::::::.:: . .:: ..: :..:. :...:.:: : :..::::.
XP_016 HPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQ
220 230 240 250 260 270
540 550 560 570 580
pF1KA0 QQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGPQL------RDLCSLAAEGIWQKKTL
::.. : ::.:::.. . :: . .: .: .:.: : ::::::.:.:..: :
XP_016 QQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKIL
280 290 300 310 320 330
590 600 610 620 630 640
pF1KA0 FSPDDLRKHGLDGAIISTFLKMGILQEH-PIPLSYSFIHLCFQEFFAAMSYVL-EDEKGR
: .::::::::: .:.::.:.:.:. :::::: :::::::: :.: : : :
XP_016 FEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGA
340 350 360 370 380 390
650 660 670 680 690 700
pF1KA0 GKHSNCIIDLEKTLEAYGI-HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNL
: . :. . : :.. . : : :.:::.:::..: . ..:. . ..: .:
XP_016 GPDQ----DVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDL
400 410 420 430 440 450
710 720 730 740 750
pF1KA0 MQWVPSLQL----LLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMC-VETDMELLVCT
.::. : :: ::: . :::: ... :. :...::. . . . . :: .: .
XP_016 LQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSS
460 470 480 490 500 510
760 770 780 790 800
pF1KA0 FCIKFSRHVKKLQLI--------EGRQHRSTWSPTMVVLFR--WVPVTDAYWQILFSVLK
::.: : .. :.: : : . :. . :..: .: . . ::: . : ..:
XP_016 FCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLRPERTVLLDAYSEHLAAALC
520 530 540 550 560 570
810 820 830 840 850 860
pF1KA0 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ
.. :: ::.: :.:. .:: ::. ::.: : :..::: : ... :.::. .: ::.
XP_016 TNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANK
580 590 600 610 620 630
870 880 890 900 910 920
pF1KA0 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK
.::..::: : . : ::. ::.:.:.:: .:: .: : : ::..::::...: :
XP_016 NLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLV
640 650 660 670 680 690
930 940 950 960 970 980
pF1KA0 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS----DEMRQELRALEQEKPQL
:::: : :.:.:.::::.:::::.:.: : : :. ::. . : . .. .
XP_016 ELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELD
700 710 720 730 740 750
990 1000 1010 1020 1030
pF1KA0 LIFSRRKP-SVMTPTEGLDTGEMSNSTSSLKRQRLGSE--RAASHVAQAN--LKLLDVSK
: ... .:. ::: . .: : :::: .. : : ::: :. ::.:
XP_016 LSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSF
760 770 780 790 800 810
1040 1050 1060 1070 1080 1090
pF1KA0 IFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKN
XP_016 NDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNAL
820 830 840 850 860 870
>--
initn: 519 init1: 276 opt: 276 Z-score: 225.4 bits: 53.6 E(85289): 8.1e-06
Smith-Waterman score: 276; 44.5% identity (65.5% similar) in 110 aa overlap (874-983:812-921)
850 860 870 880 890 900
pF1KA0 LAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVS
:: : : : : . :..:.:.::.: : :
XP_016 LGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDS
790 800 810 820 830 840
910 920 930 940 950 960
pF1KA0 CGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTL
::::. :..: .:. . .: .: : .: : :.::::::. : ::.::: : : :
XP_016 CGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDL
850 860 870 880 890 900
970 980 990 1000 1010 1020
pF1KA0 SDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERAASH
. ...: ::. :: : :
XP_016 NKMTHSRLAALRVTKPYLDIGC
910 920
>>XP_016882952 (OMIM: 609648,611762) PREDICTED: NACHT, L (923 aa)
initn: 2262 init1: 544 opt: 1095 Z-score: 872.2 bits: 173.3 E(85289): 7.7e-42
Smith-Waterman score: 1722; 40.2% identity (65.6% similar) in 809 aa overlap (273-1035:13-811)
250 260 270 280 290 300
pF1KA0 QAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPD
......:.:::. . : ..:. . .
XP_016 MEDRNARLGECVNLSHRYTRLLLV-KEH---SNPM--QVQQQ
10 20 30
310 320 330 340 350
pF1KA0 YVEENRGHL---------IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWG
.. .::: :.:. :: : . :: : :..::::::::: ::..: :.
XP_016 LLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWA
40 50 60 70 80 90
360 370 380 390 400 410
pF1KA0 RGQLYGDRFQHVFYFSCRELAQSKV-VSLAELIGKDGTATPAPIRQILSRPERLLFILDG
:.:. ::...::..:::. :: . :. .:: . ::..... :::::::.::
XP_016 DGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDG
100 110 120 130 140 150
420 430 440 450 460 470
pF1KA0 VDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLE
:: ...:.. :: : . .:.. ::.::. : .::: :.:::.: :::..: ::
XP_016 FDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLE
160 170 180 190 200 210
480 490 500 510 520 530
pF1KA0 QARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLM
. : ::.:::::. ::::::.:: . .:: ..: :..:. :...:.:: : :..::::.
XP_016 HPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQ
220 230 240 250 260 270
540 550 560 570 580
pF1KA0 QQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGPQL------RDLCSLAAEGIWQKKTL
::.. : ::.:::.. . :: . .: .: .:.: : ::::::.:.:..: :
XP_016 QQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKIL
280 290 300 310 320 330
590 600 610 620 630 640
pF1KA0 FSPDDLRKHGLDGAIISTFLKMGILQEH-PIPLSYSFIHLCFQEFFAAMSYVL-EDEKGR
: .::::::::: .:.::.:.:.:. :::::: :::::::: :.: : : :
XP_016 FEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGA
340 350 360 370 380 390
650 660 670 680 690 700
pF1KA0 GKHSNCIIDLEKTLEAYGI-HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNL
: . :. . : :.. . : : :.:::.:::..: . ..:. . ..: .:
XP_016 GPDQ----DVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDL
400 410 420 430 440 450
710 720 730 740 750
pF1KA0 MQWVPSLQL----LLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMC-VETDMELLVCT
.::. : :: ::: . :::: ... :. :...::. . . . . :: .: .
XP_016 LQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSS
460 470 480 490 500 510
760 770 780 790 800
pF1KA0 FCIKFSRHVKKLQLI--------EGRQHRSTWSPTMVVLFR--WVPVTDAYWQILFSVLK
::.: : .. :.: : : . :. . :..: .: . . ::: . : ..:
XP_016 FCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLRPERTVLLDAYSEHLAAALC
520 530 540 550 560 570
810 820 830 840 850 860
pF1KA0 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ
.. :: ::.: :.:. .:: ::. ::.: : :..::: : ... :.::. .: ::.
XP_016 TNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANK
580 590 600 610 620 630
870 880 890 900 910 920
pF1KA0 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK
.::..::: : . : ::. ::.:.:.:: .:: .: : : ::..::::...: :
XP_016 NLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLV
640 650 660 670 680 690
930 940 950 960 970 980
pF1KA0 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS----DEMRQELRALEQEKPQL
:::: : :.:.:.::::.:::::.:.: : : :. ::. . : . .. .
XP_016 ELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELD
700 710 720 730 740 750
990 1000 1010 1020 1030
pF1KA0 LIFSRRKP-SVMTPTEGLDTGEMSNSTSSLKRQRLGSE--RAASHVAQAN--LKLLDVSK
: ... .:. ::: . .: : :::: .. : : ::: :. ::.:
XP_016 LSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSF
760 770 780 790 800 810
1040 1050 1060 1070 1080 1090
pF1KA0 IFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKN
XP_016 NDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNAL
820 830 840 850 860 870
>--
initn: 519 init1: 276 opt: 276 Z-score: 225.4 bits: 53.6 E(85289): 8.1e-06
Smith-Waterman score: 276; 44.5% identity (65.5% similar) in 110 aa overlap (874-983:812-921)
850 860 870 880 890 900
pF1KA0 LAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVS
:: : : : : . :..:.:.::.: : :
XP_016 LGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDS
790 800 810 820 830 840
910 920 930 940 950 960
pF1KA0 CGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTL
::::. :..: .:. . .: .: : .: : :.::::::. : ::.::: : : :
XP_016 CGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDL
850 860 870 880 890 900
970 980 990 1000 1010 1020
pF1KA0 SDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERAASH
. ...: ::. :: : :
XP_016 NKMTHSRLAALRVTKPYLDIGC
910 920
1429 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 19:59:23 2016 done: Wed Nov 2 19:59:25 2016
Total Scan time: 11.260 Total Display time: 0.490
Function used was FASTA [36.3.4 Apr, 2011]