Result of FASTA (omim) for pF1KA0937
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA0937, 619 aa
  1>>>pF1KA0937 619 - 619 aa - 619 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.9133+/-0.000358; mu= -1.6869+/- 0.022
 mean_var=264.6305+/-54.070, 0's: 0 Z-trim(121.7): 46  B-trim: 0 in 0/61
 Lambda= 0.078841
 statistics sampled from 38669 (38715) to 38669 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.774), E-opt: 0.2 (0.454), width:  16
 Scan time: 11.060

The best scores are:                                      opt bits E(85289)
NP_055992 (OMIM: 616110) E3 ubiquitin-protein liga ( 619) 4262 498.2 3.4e-140
XP_006718546 (OMIM: 616110) PREDICTED: E3 ubiquiti ( 513) 3508 412.4 1.9e-114
NP_001287656 (OMIM: 616110) E3 ubiquitin-protein l ( 513) 3508 412.4 1.9e-114
XP_011536311 (OMIM: 602582) PREDICTED: E3 ubiquiti ( 620) 1871 226.3 2.5e-58
NP_004407 (OMIM: 602582) E3 ubiquitin-protein liga ( 620) 1871 226.3 2.5e-58
XP_016867213 (OMIM: 613141) PREDICTED: probable E3 ( 622) 1316 163.2 2.5e-39
XP_005250188 (OMIM: 613141) PREDICTED: probable E3 ( 622) 1316 163.2 2.5e-39
XP_011514076 (OMIM: 613141) PREDICTED: probable E3 ( 622) 1316 163.2 2.5e-39
XP_016867214 (OMIM: 613141) PREDICTED: probable E3 ( 622) 1316 163.2 2.5e-39
XP_016867212 (OMIM: 613141) PREDICTED: probable E3 ( 622) 1316 163.2 2.5e-39
NP_001096065 (OMIM: 613141) probable E3 ubiquitin- ( 622) 1316 163.2 2.5e-39
NP_065943 (OMIM: 613141) probable E3 ubiquitin-pro ( 622) 1316 163.2 2.5e-39
XP_011514077 (OMIM: 613141) PREDICTED: probable E3 ( 622) 1316 163.2 2.5e-39
XP_011514075 (OMIM: 613141) PREDICTED: probable E3 ( 622) 1316 163.2 2.5e-39
XP_005250189 (OMIM: 613141) PREDICTED: probable E3 ( 622) 1316 163.2 2.5e-39
XP_011514074 (OMIM: 613141) PREDICTED: probable E3 ( 622) 1316 163.2 2.5e-39
NP_001096064 (OMIM: 613141) probable E3 ubiquitin- ( 622) 1316 163.2 2.5e-39
XP_016867215 (OMIM: 613141) PREDICTED: probable E3 ( 575) 1153 144.6 9.1e-34
XP_016867216 (OMIM: 613141) PREDICTED: probable E3 ( 575) 1153 144.6 9.1e-34
NP_001096066 (OMIM: 613141) probable E3 ubiquitin- ( 575) 1153 144.6 9.1e-34
XP_016867217 (OMIM: 613141) PREDICTED: probable E3 ( 568)  590 80.5 1.7e-14
NP_612144 (OMIM: 613143) E3 ubiquitin-protein liga ( 740)  508 71.3 1.3e-11
XP_016867219 (OMIM: 613141) PREDICTED: probable E3 ( 414)  502 70.4 1.4e-11
XP_016867218 (OMIM: 613141) PREDICTED: probable E3 ( 419)  502 70.4 1.4e-11
XP_011536324 (OMIM: 613142) PREDICTED: probable E3 ( 347)  424 61.5 5.6e-09
NP_001273175 (OMIM: 613142) probable E3 ubiquitin- ( 347)  424 61.5 5.6e-09
XP_005268760 (OMIM: 613142) PREDICTED: probable E3 ( 347)  424 61.5 5.6e-09
NP_848597 (OMIM: 613142) probable E3 ubiquitin-pro ( 347)  424 61.5 5.6e-09
XP_005268754 (OMIM: 613142) PREDICTED: probable E3 ( 350)  424 61.5 5.6e-09
XP_005268757 (OMIM: 613142) PREDICTED: probable E3 ( 350)  424 61.5 5.6e-09
XP_005268755 (OMIM: 613142) PREDICTED: probable E3 ( 350)  424 61.5 5.6e-09
NP_001273174 (OMIM: 613142) probable E3 ubiquitin- ( 350)  424 61.5 5.6e-09


>>NP_055992 (OMIM: 616110) E3 ubiquitin-protein ligase D  (619 aa)
 initn: 4262 init1: 4262 opt: 4262  Z-score: 2638.0  bits: 498.2 E(85289): 3.4e-140
Smith-Waterman score: 4262; 100.0% identity (100.0% similar) in 619 aa overlap (1-619:1-619)

               10        20        30        40        50        60
pF1KA0 MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGGSVVLGQVDSRLAPYIIDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGGSVVLGQVDSRLAPYIIDL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 QSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGSWTPYDMEVGITIQHAYEKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGSWTPYDMEVGITIQHAYEKQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 HPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLIYPMVTGTLPKAQSWPVSPGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 HPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLIYPMVTGTLPKAQSWPVSPGP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 ATSPPMSPCSCPQCVLVMSVKAAVVNGSTGPLQLPVTRKNMPPPGVVKLPPLPGSGAKPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ATSPPMSPCSCPQCVLVMSVKAAVVNGSTGPLQLPVTRKNMPPPGVVKLPPLPGSGAKPL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 DSTGTIRGPLKTAPSQVIRRQASSMPTGTTMGSPASPPGPNSKTGRVALATLNRTNLQRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DSTGTIRGPLKTAPSQVIRRQASSMPTGTTMGSPASPPGPNSKTGRVALATLNRTNLQRL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 AIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 VSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPDEDCTICMERLTAPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPDEDCTICMERLTAPS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 GYKGPQPTVKPDLVGKLSRCGHVYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GYKGPQPTVKPDLVGKLSRCGHVYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 GKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 RKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNV
              550       560       570       580       590       600

              610         
pF1KA0 LAELAAQGISEDSTAQEKD
       :::::::::::::::::::
NP_055 LAELAAQGISEDSTAQEKD
              610         

>>XP_006718546 (OMIM: 616110) PREDICTED: E3 ubiquitin-pr  (513 aa)
 initn: 3508 init1: 3508 opt: 3508  Z-score: 2175.6  bits: 412.4 E(85289): 1.9e-114
Smith-Waterman score: 3508; 100.0% identity (100.0% similar) in 513 aa overlap (107-619:1-513)

         80        90       100       110       120       130      
pF1KA0 RRNYYDPSSAPGKGVVWEWENDNGSWTPYDMEVGITIQHAYEKQHPWIDLTSIGFSYVID
                                     ::::::::::::::::::::::::::::::
XP_006                               MEVGITIQHAYEKQHPWIDLTSIGFSYVID
                                             10        20        30

        140       150       160       170       180       190      
pF1KA0 FNTMGQINRQTQRQRRVRRRLDLIYPMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FNTMGQINRQTQRQRRVRRRLDLIYPMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVL
               40        50        60        70        80        90

        200       210       220       230       240       250      
pF1KA0 VMSVKAAVVNGSTGPLQLPVTRKNMPPPGVVKLPPLPGSGAKPLDSTGTIRGPLKTAPSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VMSVKAAVVNGSTGPLQLPVTRKNMPPPGVVKLPPLPGSGAKPLDSTGTIRGPLKTAPSQ
              100       110       120       130       140       150

        260       270       280       290       300       310      
pF1KA0 VIRRQASSMPTGTTMGSPASPPGPNSKTGRVALATLNRTNLQRLAIAQSRVLIASGVPTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VIRRQASSMPTGTTMGSPASPPGPNSKTGRVALATLNRTNLQRLAIAQSRVLIASGVPTV
              160       170       180       190       200       210

        320       330       340       350       360       370      
pF1KA0 PVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTS
              220       230       240       250       260       270

        380       390       400       410       420       430      
pF1KA0 RKTTKKQAKKGKTPEEVLKKYLQKVRHPPDEDCTICMERLTAPSGYKGPQPTVKPDLVGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RKTTKKQAKKGKTPEEVLKKYLQKVRHPPDEDCTICMERLTAPSGYKGPQPTVKPDLVGK
              280       290       300       310       320       330

        440       450       460       470       480       490      
pF1KA0 LSRCGHVYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSRCGHVYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHP
              340       350       360       370       380       390

        500       510       520       530       540       550      
pF1KA0 DCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLI
              400       410       420       430       440       450

        560       570       580       590       600       610      
pF1KA0 FAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQ
              460       470       480       490       500       510

          
pF1KA0 EKD
       :::
XP_006 EKD
          

>>NP_001287656 (OMIM: 616110) E3 ubiquitin-protein ligas  (513 aa)
 initn: 3508 init1: 3508 opt: 3508  Z-score: 2175.6  bits: 412.4 E(85289): 1.9e-114
Smith-Waterman score: 3508; 100.0% identity (100.0% similar) in 513 aa overlap (107-619:1-513)

         80        90       100       110       120       130      
pF1KA0 RRNYYDPSSAPGKGVVWEWENDNGSWTPYDMEVGITIQHAYEKQHPWIDLTSIGFSYVID
                                     ::::::::::::::::::::::::::::::
NP_001                               MEVGITIQHAYEKQHPWIDLTSIGFSYVID
                                             10        20        30

        140       150       160       170       180       190      
pF1KA0 FNTMGQINRQTQRQRRVRRRLDLIYPMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FNTMGQINRQTQRQRRVRRRLDLIYPMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVL
               40        50        60        70        80        90

        200       210       220       230       240       250      
pF1KA0 VMSVKAAVVNGSTGPLQLPVTRKNMPPPGVVKLPPLPGSGAKPLDSTGTIRGPLKTAPSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMSVKAAVVNGSTGPLQLPVTRKNMPPPGVVKLPPLPGSGAKPLDSTGTIRGPLKTAPSQ
              100       110       120       130       140       150

        260       270       280       290       300       310      
pF1KA0 VIRRQASSMPTGTTMGSPASPPGPNSKTGRVALATLNRTNLQRLAIAQSRVLIASGVPTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIRRQASSMPTGTTMGSPASPPGPNSKTGRVALATLNRTNLQRLAIAQSRVLIASGVPTV
              160       170       180       190       200       210

        320       330       340       350       360       370      
pF1KA0 PVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTS
              220       230       240       250       260       270

        380       390       400       410       420       430      
pF1KA0 RKTTKKQAKKGKTPEEVLKKYLQKVRHPPDEDCTICMERLTAPSGYKGPQPTVKPDLVGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKTTKKQAKKGKTPEEVLKKYLQKVRHPPDEDCTICMERLTAPSGYKGPQPTVKPDLVGK
              280       290       300       310       320       330

        440       450       460       470       480       490      
pF1KA0 LSRCGHVYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSRCGHVYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHP
              340       350       360       370       380       390

        500       510       520       530       540       550      
pF1KA0 DCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLI
              400       410       420       430       440       450

        560       570       580       590       600       610      
pF1KA0 FAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQ
              460       470       480       490       500       510

          
pF1KA0 EKD
       :::
NP_001 EKD
          

>>XP_011536311 (OMIM: 602582) PREDICTED: E3 ubiquitin-pr  (620 aa)
 initn: 2559 init1: 1130 opt: 1871  Z-score: 1168.2  bits: 226.3 E(85289): 2.5e-58
Smith-Waterman score: 2758; 64.9% identity (84.4% similar) in 610 aa overlap (7-611:25-615)

                                 10        20        30        40  
pF1KA0                   MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGG
                               ::::::::::.:::::. .: :::: :..   :  :
XP_011 MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIENVLKEDAR--G
               10        20        30        40        50          

             50        60        70        80        90       100  
pF1KA0 SVVLGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGSW
       ::::::::..:.:::::::::.::::::::.::::::.::::::::::.:::::::.:.:
XP_011 SVVLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEWENDGGAW
       60        70        80        90       100       110        

            110       120       130       140       150       160  
pF1KA0 TPYDMEVGITIQHAYEKQHPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLIYP
       : :::.. ::::.::::::::.::.:.:: :.: ::.:.:.::::.:.::.:::::: ::
XP_011 TAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYP
      120       130       140       150       160       170        

            170       180       190       200       210       220  
pF1KA0 MVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVLVMSVKAAVVNGSTGPLQLPVTRKNMP
       ...:..::.:::::.   :.:   .:::: ::.:: :..::     .. . :   :.. :
XP_011 LTVGSIPKSQSWPVG---ASSG--QPCSCQQCLLVNSTRAA-----SNAI-LASQRRKAP
      180       190            200       210             220       

            230         240        250       260       270         
pF1KA0 PPGVVKLPPLPGS--GAKPLDSTGTIRGP-LKTAPSQVIRRQASSMPTGTTMGSPASPPG
       :   .  :: ::.  ::  .  ..:. :  : .::.    . :   : :.   ::..: :
XP_011 PAPPLPPPPPPGGPPGALAVRPSATFTGAALWAAPAAGPAEPAP--PPGAPPRSPGAPGG
       230       240       250       260       270         280     

     280       290       300       310       320       330         
pF1KA0 PNSKTGRVALATLNRTNLQRLAIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGILM
         .  :.    .::: . :: . ...:. :  :::..:::::::..::.:::::.::::.
XP_011 ARTP-GQ---NNLNRPGPQRTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILL
          290          300       310       320       330       340 

     340       350       360       370       380       390         
pF1KA0 SAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQ
        :::::::::: :: .:::::::::..: .::: .. ::: ::. ::.:.::.:...:.:
XP_011 CAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQ
             350       360       370       380       390       400 

     400       410       420         430       440       450       
pF1KA0 KVRHPPDEDCTICMERLTAPSGYKGP--QPTVKPDLVGKLSRCGHVYHIYCLVAMYNNGN
       ::..:::::::::::::.. :::.:   .  :.:.:::.:.::::.::. ::::::.:::
XP_011 KVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLVAMYSNGN
             410       420       430       440       450       460 

       460       470       480       490       500       510       
pF1KA0 KDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHP
       :::::::::::.::: :::::::::::.::::::::: :: .::::.:.:: ::::::::
XP_011 KDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHP
             470       480       490       500       510       520 

       520       530       540       550       560       570       
pF1KA0 NPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVH
       ::::.:.:::::::::::..:::::::.::..::.:::::.::::.::::::::.:::.:
XP_011 NPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIH
             530       540       550       560       570       580 

       580       590       600       610         
pF1KA0 HKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQEKD
       :::::::::::::::::.:::::::::.:::.::        
XP_011 HKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSEAAAKA   
             590       600       610       620   

>>NP_004407 (OMIM: 602582) E3 ubiquitin-protein ligase D  (620 aa)
 initn: 2559 init1: 1130 opt: 1871  Z-score: 1168.2  bits: 226.3 E(85289): 2.5e-58
Smith-Waterman score: 2758; 64.9% identity (84.4% similar) in 610 aa overlap (7-611:25-615)

                                 10        20        30        40  
pF1KA0                   MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGG
                               ::::::::::.:::::. .: :::: :..   :  :
NP_004 MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIENVLKEDAR--G
               10        20        30        40        50          

             50        60        70        80        90       100  
pF1KA0 SVVLGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGSW
       ::::::::..:.:::::::::.::::::::.::::::.::::::::::.:::::::.:.:
NP_004 SVVLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEWENDGGAW
       60        70        80        90       100       110        

            110       120       130       140       150       160  
pF1KA0 TPYDMEVGITIQHAYEKQHPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLIYP
       : :::.. ::::.::::::::.::.:.:: :.: ::.:.:.::::.:.::.:::::: ::
NP_004 TAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYP
      120       130       140       150       160       170        

            170       180       190       200       210       220  
pF1KA0 MVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVLVMSVKAAVVNGSTGPLQLPVTRKNMP
       ...:..::.:::::.   :.:   .:::: ::.:: :..::     .. . :   :.. :
NP_004 LTVGSIPKSQSWPVG---ASSG--QPCSCQQCLLVNSTRAA-----SNAI-LASQRRKAP
      180       190            200       210             220       

            230         240        250       260       270         
pF1KA0 PPGVVKLPPLPGS--GAKPLDSTGTIRGP-LKTAPSQVIRRQASSMPTGTTMGSPASPPG
       :   .  :: ::.  ::  .  ..:. :  : .::.    . :   : :.   ::..: :
NP_004 PAPPLPPPPPPGGPPGALAVRPSATFTGAALWAAPAAGPAEPAP--PPGAPPRSPGAPGG
       230       240       250       260       270         280     

     280       290       300       310       320       330         
pF1KA0 PNSKTGRVALATLNRTNLQRLAIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGILM
         .  :.    .::: . :: . ...:. :  :::..:::::::..::.:::::.::::.
NP_004 ARTP-GQ---NNLNRPGPQRTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILL
          290          300       310       320       330       340 

     340       350       360       370       380       390         
pF1KA0 SAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQ
        :::::::::: :: .:::::::::..: .::: .. ::: ::. ::.:.::.:...:.:
NP_004 CAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQ
             350       360       370       380       390       400 

     400       410       420         430       440       450       
pF1KA0 KVRHPPDEDCTICMERLTAPSGYKGP--QPTVKPDLVGKLSRCGHVYHIYCLVAMYNNGN
       ::..:::::::::::::.. :::.:   .  :.:.:::.:.::::.::. ::::::.:::
NP_004 KVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLVAMYSNGN
             410       420       430       440       450       460 

       460       470       480       490       500       510       
pF1KA0 KDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHP
       :::::::::::.::: :::::::::::.::::::::: :: .::::.:.:: ::::::::
NP_004 KDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHP
             470       480       490       500       510       520 

       520       530       540       550       560       570       
pF1KA0 NPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVH
       ::::.:.:::::::::::..:::::::.::..::.:::::.::::.::::::::.:::.:
NP_004 NPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIH
             530       540       550       560       570       580 

       580       590       600       610         
pF1KA0 HKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQEKD
       :::::::::::::::::.:::::::::.:::.::        
NP_004 HKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSEAAAKA   
             590       600       610       620   

>>XP_016867213 (OMIM: 613141) PREDICTED: probable E3 ubi  (622 aa)
 initn: 1763 init1: 984 opt: 1316  Z-score: 827.0  bits: 163.2 E(85289): 2.5e-39
Smith-Waterman score: 1763; 46.9% identity (67.1% similar) in 635 aa overlap (5-617:17-622)

                           10        20        30          40      
pF1KA0             MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEA--VVRAGPRAG-GSVV
                       .::.:::: .  : :.::: .:   ::   : . : : : ::..
XP_016 MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRFGLGSLA
               10        20        30        40        50        60

              50        60        70        80        90       100 
pF1KA0 ----LGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGS
           :::.:  :::::::: : .::::::::.: :::. .   ::::.:::::: .:.::
XP_016 HSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEWLSDDGS
               70        80        90       100       110       120

             110       120       130       140       150       160 
pF1KA0 WTPYDMEVGITIQHAYEKQHPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLIY
       :: :.  :   ...   . .  .::. .:..:.....:  : :. ..  : :::.    :
XP_016 WTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHTQTNKTSSFCRSVRRQAGPPY
              130       140       150       160       170       180

             170       180       190       200        210       220
pF1KA0 PMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVLVMSVKAAVVNGS-TGPLQLPVTRKN
       :..:   :     :   : :       ::: ::.          .:: :::..    :..
XP_016 PVTTIIAP-----PGHTGVA-------CSCHQCL----------SGSRTGPVS-GRYRHS
                   190              200                 210        

              230       240       250       260       270       280
pF1KA0 MPPPGVVKLPPLPGSGAKPLDSTGTIRGPLKTAPSQVIRRQASSMPTGTTMGSPASPPGP
       :    .  .:  :   .  . .:    .: .  ::    :.:  . : .. :  :.::. 
XP_016 MTNLPAYPVPQHPPHRTASVFGTHQAFAPYNK-PSLSGARSAPRLNTTNAWG--AAPPSL
       220       230       240        250       260         270    

               290       300         310               320         
pF1KA0 NSKT-GRVALATLNRTNLQRLAIAQSRVL--IASG-------VP-TVPVKNLNGSSPVNP
       .:.   : .:. :.  .:   . ... :   . ::       :: :::.. .   : :. 
XP_016 GSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQ-MPKPSRVQQ
          280       290       300       310       320        330   

     330       340       350       360       370       380         
pF1KA0 ALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKT
       ::::.:..:::: ::::::.: :. .   ::.:.   ::  .:.   . ..:  . : . 
XP_016 ALAGMTSVLMSAIGLPVCLSRAPQPT--SPPASRLASKSHGSVKRLRKMSVKGATPKPEP
           340       350         360       370       380       390 

      390       400       410       420         430       440      
pF1KA0 -PEEVLKKYLQKVRHPPDEDCTICMERLTAPSGYKG--PQPTVKPDLVGKLSRCGHVYHI
        ::.:.:.: .... :::::: ::::.:.. :::.    . ..    ::.:..:.:..:.
XP_016 EPEQVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHL
             400       410       420       430       440       450 

        450       460       470       480       490       500      
pF1KA0 YCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYS
        ::.::: :::::::::::.:::::: :::::: ::::   .  ::::: :: :: :.::
XP_016 LCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYS
             460       470       480       490       500       510 

        510       520       530       540       550       560      
pF1KA0 IPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTG
       :: :::::::::::: :.::::::.:::::. .:::::.:: ::: :::::..:::::::
XP_016 IPHGIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTG
             520       530       540       550       560       570 

        570       580       590       600       610         
pF1KA0 ESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQEKD
       :.:::.:::.:::::.  :.::::::: :::.::::::::::..::   :.  
XP_016 ETDTVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ  
             580       590       600       610       620    

>>XP_005250188 (OMIM: 613141) PREDICTED: probable E3 ubi  (622 aa)
 initn: 1763 init1: 984 opt: 1316  Z-score: 827.0  bits: 163.2 E(85289): 2.5e-39
Smith-Waterman score: 1763; 46.9% identity (67.1% similar) in 635 aa overlap (5-617:17-622)

                           10        20        30          40      
pF1KA0             MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEA--VVRAGPRAG-GSVV
                       .::.:::: .  : :.::: .:   ::   : . : : : ::..
XP_005 MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRFGLGSLA
               10        20        30        40        50        60

              50        60        70        80        90       100 
pF1KA0 ----LGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGS
           :::.:  :::::::: : .::::::::.: :::. .   ::::.:::::: .:.::
XP_005 HSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEWLSDDGS
               70        80        90       100       110       120

             110       120       130       140       150       160 
pF1KA0 WTPYDMEVGITIQHAYEKQHPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLIY
       :: :.  :   ...   . .  .::. .:..:.....:  : :. ..  : :::.    :
XP_005 WTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHTQTNKTSSFCRSVRRQAGPPY
              130       140       150       160       170       180

             170       180       190       200        210       220
pF1KA0 PMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVLVMSVKAAVVNGS-TGPLQLPVTRKN
       :..:   :     :   : :       ::: ::.          .:: :::..    :..
XP_005 PVTTIIAP-----PGHTGVA-------CSCHQCL----------SGSRTGPVS-GRYRHS
                   190              200                 210        

              230       240       250       260       270       280
pF1KA0 MPPPGVVKLPPLPGSGAKPLDSTGTIRGPLKTAPSQVIRRQASSMPTGTTMGSPASPPGP
       :    .  .:  :   .  . .:    .: .  ::    :.:  . : .. :  :.::. 
XP_005 MTNLPAYPVPQHPPHRTASVFGTHQAFAPYNK-PSLSGARSAPRLNTTNAWG--AAPPSL
       220       230       240        250       260         270    

               290       300         310               320         
pF1KA0 NSKT-GRVALATLNRTNLQRLAIAQSRVL--IASG-------VP-TVPVKNLNGSSPVNP
       .:.   : .:. :.  .:   . ... :   . ::       :: :::.. .   : :. 
XP_005 GSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQ-MPKPSRVQQ
          280       290       300       310       320        330   

     330       340       350       360       370       380         
pF1KA0 ALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKT
       ::::.:..:::: ::::::.: :. .   ::.:.   ::  .:.   . ..:  . : . 
XP_005 ALAGMTSVLMSAIGLPVCLSRAPQPT--SPPASRLASKSHGSVKRLRKMSVKGATPKPEP
           340       350         360       370       380       390 

      390       400       410       420         430       440      
pF1KA0 -PEEVLKKYLQKVRHPPDEDCTICMERLTAPSGYKG--PQPTVKPDLVGKLSRCGHVYHI
        ::.:.:.: .... :::::: ::::.:.. :::.    . ..    ::.:..:.:..:.
XP_005 EPEQVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHL
             400       410       420       430       440       450 

        450       460       470       480       490       500      
pF1KA0 YCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYS
        ::.::: :::::::::::.:::::: :::::: ::::   .  ::::: :: :: :.::
XP_005 LCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYS
             460       470       480       490       500       510 

        510       520       530       540       550       560      
pF1KA0 IPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTG
       :: :::::::::::: :.::::::.:::::. .:::::.:: ::: :::::..:::::::
XP_005 IPHGIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTG
             520       530       540       550       560       570 

        570       580       590       600       610         
pF1KA0 ESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQEKD
       :.:::.:::.:::::.  :.::::::: :::.::::::::::..::   :.  
XP_005 ETDTVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ  
             580       590       600       610       620    

>>XP_011514076 (OMIM: 613141) PREDICTED: probable E3 ubi  (622 aa)
 initn: 1763 init1: 984 opt: 1316  Z-score: 827.0  bits: 163.2 E(85289): 2.5e-39
Smith-Waterman score: 1763; 46.9% identity (67.1% similar) in 635 aa overlap (5-617:17-622)

                           10        20        30          40      
pF1KA0             MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEA--VVRAGPRAG-GSVV
                       .::.:::: .  : :.::: .:   ::   : . : : : ::..
XP_011 MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRFGLGSLA
               10        20        30        40        50        60

              50        60        70        80        90       100 
pF1KA0 ----LGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGS
           :::.:  :::::::: : .::::::::.: :::. .   ::::.:::::: .:.::
XP_011 HSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEWLSDDGS
               70        80        90       100       110       120

             110       120       130       140       150       160 
pF1KA0 WTPYDMEVGITIQHAYEKQHPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLIY
       :: :.  :   ...   . .  .::. .:..:.....:  : :. ..  : :::.    :
XP_011 WTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHTQTNKTSSFCRSVRRQAGPPY
              130       140       150       160       170       180

             170       180       190       200        210       220
pF1KA0 PMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVLVMSVKAAVVNGS-TGPLQLPVTRKN
       :..:   :     :   : :       ::: ::.          .:: :::..    :..
XP_011 PVTTIIAP-----PGHTGVA-------CSCHQCL----------SGSRTGPVS-GRYRHS
                   190              200                 210        

              230       240       250       260       270       280
pF1KA0 MPPPGVVKLPPLPGSGAKPLDSTGTIRGPLKTAPSQVIRRQASSMPTGTTMGSPASPPGP
       :    .  .:  :   .  . .:    .: .  ::    :.:  . : .. :  :.::. 
XP_011 MTNLPAYPVPQHPPHRTASVFGTHQAFAPYNK-PSLSGARSAPRLNTTNAWG--AAPPSL
       220       230       240        250       260         270    

               290       300         310               320         
pF1KA0 NSKT-GRVALATLNRTNLQRLAIAQSRVL--IASG-------VP-TVPVKNLNGSSPVNP
       .:.   : .:. :.  .:   . ... :   . ::       :: :::.. .   : :. 
XP_011 GSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQ-MPKPSRVQQ
          280       290       300       310       320        330   

     330       340       350       360       370       380         
pF1KA0 ALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKT
       ::::.:..:::: ::::::.: :. .   ::.:.   ::  .:.   . ..:  . : . 
XP_011 ALAGMTSVLMSAIGLPVCLSRAPQPT--SPPASRLASKSHGSVKRLRKMSVKGATPKPEP
           340       350         360       370       380       390 

      390       400       410       420         430       440      
pF1KA0 -PEEVLKKYLQKVRHPPDEDCTICMERLTAPSGYKG--PQPTVKPDLVGKLSRCGHVYHI
        ::.:.:.: .... :::::: ::::.:.. :::.    . ..    ::.:..:.:..:.
XP_011 EPEQVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHL
             400       410       420       430       440       450 

        450       460       470       480       490       500      
pF1KA0 YCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYS
        ::.::: :::::::::::.:::::: :::::: ::::   .  ::::: :: :: :.::
XP_011 LCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYS
             460       470       480       490       500       510 

        510       520       530       540       550       560      
pF1KA0 IPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTG
       :: :::::::::::: :.::::::.:::::. .:::::.:: ::: :::::..:::::::
XP_011 IPHGIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTG
             520       530       540       550       560       570 

        570       580       590       600       610         
pF1KA0 ESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQEKD
       :.:::.:::.:::::.  :.::::::: :::.::::::::::..::   :.  
XP_011 ETDTVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ  
             580       590       600       610       620    

>>XP_016867214 (OMIM: 613141) PREDICTED: probable E3 ubi  (622 aa)
 initn: 1763 init1: 984 opt: 1316  Z-score: 827.0  bits: 163.2 E(85289): 2.5e-39
Smith-Waterman score: 1763; 46.9% identity (67.1% similar) in 635 aa overlap (5-617:17-622)

                           10        20        30          40      
pF1KA0             MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEA--VVRAGPRAG-GSVV
                       .::.:::: .  : :.::: .:   ::   : . : : : ::..
XP_016 MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRFGLGSLA
               10        20        30        40        50        60

              50        60        70        80        90       100 
pF1KA0 ----LGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGS
           :::.:  :::::::: : .::::::::.: :::. .   ::::.:::::: .:.::
XP_016 HSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEWLSDDGS
               70        80        90       100       110       120

             110       120       130       140       150       160 
pF1KA0 WTPYDMEVGITIQHAYEKQHPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLIY
       :: :.  :   ...   . .  .::. .:..:.....:  : :. ..  : :::.    :
XP_016 WTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHTQTNKTSSFCRSVRRQAGPPY
              130       140       150       160       170       180

             170       180       190       200        210       220
pF1KA0 PMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVLVMSVKAAVVNGS-TGPLQLPVTRKN
       :..:   :     :   : :       ::: ::.          .:: :::..    :..
XP_016 PVTTIIAP-----PGHTGVA-------CSCHQCL----------SGSRTGPVS-GRYRHS
                   190              200                 210        

              230       240       250       260       270       280
pF1KA0 MPPPGVVKLPPLPGSGAKPLDSTGTIRGPLKTAPSQVIRRQASSMPTGTTMGSPASPPGP
       :    .  .:  :   .  . .:    .: .  ::    :.:  . : .. :  :.::. 
XP_016 MTNLPAYPVPQHPPHRTASVFGTHQAFAPYNK-PSLSGARSAPRLNTTNAWG--AAPPSL
       220       230       240        250       260         270    

               290       300         310               320         
pF1KA0 NSKT-GRVALATLNRTNLQRLAIAQSRVL--IASG-------VP-TVPVKNLNGSSPVNP
       .:.   : .:. :.  .:   . ... :   . ::       :: :::.. .   : :. 
XP_016 GSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQ-MPKPSRVQQ
          280       290       300       310       320        330   

     330       340       350       360       370       380         
pF1KA0 ALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKT
       ::::.:..:::: ::::::.: :. .   ::.:.   ::  .:.   . ..:  . : . 
XP_016 ALAGMTSVLMSAIGLPVCLSRAPQPT--SPPASRLASKSHGSVKRLRKMSVKGATPKPEP
           340       350         360       370       380       390 

      390       400       410       420         430       440      
pF1KA0 -PEEVLKKYLQKVRHPPDEDCTICMERLTAPSGYKG--PQPTVKPDLVGKLSRCGHVYHI
        ::.:.:.: .... :::::: ::::.:.. :::.    . ..    ::.:..:.:..:.
XP_016 EPEQVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHL
             400       410       420       430       440       450 

        450       460       470       480       490       500      
pF1KA0 YCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYS
        ::.::: :::::::::::.:::::: :::::: ::::   .  ::::: :: :: :.::
XP_016 LCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYS
             460       470       480       490       500       510 

        510       520       530       540       550       560      
pF1KA0 IPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTG
       :: :::::::::::: :.::::::.:::::. .:::::.:: ::: :::::..:::::::
XP_016 IPHGIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTG
             520       530       540       550       560       570 

        570       580       590       600       610         
pF1KA0 ESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQEKD
       :.:::.:::.:::::.  :.::::::: :::.::::::::::..::   :.  
XP_016 ETDTVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ  
             580       590       600       610       620    

>>XP_016867212 (OMIM: 613141) PREDICTED: probable E3 ubi  (622 aa)
 initn: 1763 init1: 984 opt: 1316  Z-score: 827.0  bits: 163.2 E(85289): 2.5e-39
Smith-Waterman score: 1763; 46.9% identity (67.1% similar) in 635 aa overlap (5-617:17-622)

                           10        20        30          40      
pF1KA0             MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEA--VVRAGPRAG-GSVV
                       .::.:::: .  : :.::: .:   ::   : . : : : ::..
XP_016 MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRFGLGSLA
               10        20        30        40        50        60

              50        60        70        80        90       100 
pF1KA0 ----LGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGS
           :::.:  :::::::: : .::::::::.: :::. .   ::::.:::::: .:.::
XP_016 HSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEWLSDDGS
               70        80        90       100       110       120

             110       120       130       140       150       160 
pF1KA0 WTPYDMEVGITIQHAYEKQHPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLIY
       :: :.  :   ...   . .  .::. .:..:.....:  : :. ..  : :::.    :
XP_016 WTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHTQTNKTSSFCRSVRRQAGPPY
              130       140       150       160       170       180

             170       180       190       200        210       220
pF1KA0 PMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVLVMSVKAAVVNGS-TGPLQLPVTRKN
       :..:   :     :   : :       ::: ::.          .:: :::..    :..
XP_016 PVTTIIAP-----PGHTGVA-------CSCHQCL----------SGSRTGPVS-GRYRHS
                   190              200                 210        

              230       240       250       260       270       280
pF1KA0 MPPPGVVKLPPLPGSGAKPLDSTGTIRGPLKTAPSQVIRRQASSMPTGTTMGSPASPPGP
       :    .  .:  :   .  . .:    .: .  ::    :.:  . : .. :  :.::. 
XP_016 MTNLPAYPVPQHPPHRTASVFGTHQAFAPYNK-PSLSGARSAPRLNTTNAWG--AAPPSL
       220       230       240        250       260         270    

               290       300         310               320         
pF1KA0 NSKT-GRVALATLNRTNLQRLAIAQSRVL--IASG-------VP-TVPVKNLNGSSPVNP
       .:.   : .:. :.  .:   . ... :   . ::       :: :::.. .   : :. 
XP_016 GSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQ-MPKPSRVQQ
          280       290       300       310       320        330   

     330       340       350       360       370       380         
pF1KA0 ALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKT
       ::::.:..:::: ::::::.: :. .   ::.:.   ::  .:.   . ..:  . : . 
XP_016 ALAGMTSVLMSAIGLPVCLSRAPQPT--SPPASRLASKSHGSVKRLRKMSVKGATPKPEP
           340       350         360       370       380       390 

      390       400       410       420         430       440      
pF1KA0 -PEEVLKKYLQKVRHPPDEDCTICMERLTAPSGYKG--PQPTVKPDLVGKLSRCGHVYHI
        ::.:.:.: .... :::::: ::::.:.. :::.    . ..    ::.:..:.:..:.
XP_016 EPEQVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHL
             400       410       420       430       440       450 

        450       460       470       480       490       500      
pF1KA0 YCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYS
        ::.::: :::::::::::.:::::: :::::: ::::   .  ::::: :: :: :.::
XP_016 LCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYS
             460       470       480       490       500       510 

        510       520       530       540       550       560      
pF1KA0 IPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTG
       :: :::::::::::: :.::::::.:::::. .:::::.:: ::: :::::..:::::::
XP_016 IPHGIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTG
             520       530       540       550       560       570 

        570       580       590       600       610         
pF1KA0 ESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQEKD
       :.:::.:::.:::::.  :.::::::: :::.::::::::::..::   :.  
XP_016 ETDTVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ  
             580       590       600       610       620    




619 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Wed Nov  2 20:03:35 2016 done: Wed Nov  2 20:03:36 2016
 Total Scan time: 11.060 Total Display time:  0.080

Function used was FASTA [36.3.4 Apr, 2011]
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