FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0943, 393 aa 1>>>pF1KA0943 393 - 393 aa - 393 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1890+/-0.0008; mu= 17.5222+/- 0.048 mean_var=69.7510+/-13.816, 0's: 0 Z-trim(108.4): 12 B-trim: 0 in 0/50 Lambda= 0.153567 statistics sampled from 10150 (10158) to 10150 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.69), E-opt: 0.2 (0.312), width: 16 Scan time: 2.900 The best scores are: opt bits E(32554) CCDS46564.1 ATG4B gene_id:23192|Hs108|chr2 ( 393) 2739 615.8 2.1e-176 CCDS46565.1 ATG4B gene_id:23192|Hs108|chr2 ( 380) 2589 582.6 2e-166 CCDS14538.1 ATG4A gene_id:115201|Hs108|chrX ( 398) 1507 342.9 3.1e-94 CCDS14539.1 ATG4A gene_id:115201|Hs108|chrX ( 336) 889 205.9 4.4e-53 CCDS12241.1 ATG4D gene_id:84971|Hs108|chr19 ( 474) 588 139.3 6.9e-33 >>CCDS46564.1 ATG4B gene_id:23192|Hs108|chr2 (393 aa) initn: 2739 init1: 2739 opt: 2739 Z-score: 3280.6 bits: 615.8 E(32554): 2.1e-176 Smith-Waterman score: 2739; 99.7% identity (99.7% similar) in 393 aa overlap (1-393:1-393) 10 20 30 40 50 60 pF1KA0 MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 IGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 IGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 SYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 SYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 RLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 RLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 ETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 ETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 CQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVEQQPSHLA ::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::: CCDS46 CQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLA 310 320 330 340 350 360 370 380 390 pF1KA0 CPDVLNLSLDSSDVERLERFFDSEDEDFEILSL ::::::::::::::::::::::::::::::::: CCDS46 CPDVLNLSLDSSDVERLERFFDSEDEDFEILSL 370 380 390 >>CCDS46565.1 ATG4B gene_id:23192|Hs108|chr2 (380 aa) initn: 2589 init1: 2589 opt: 2589 Z-score: 3101.2 bits: 582.6 E(32554): 2e-166 Smith-Waterman score: 2589; 99.2% identity (99.2% similar) in 372 aa overlap (1-372:1-372) 10 20 30 40 50 60 pF1KA0 MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 IGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 IGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 SYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 SYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 RLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 RLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 ETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 ETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 CQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVEQQPSHLA ::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::: CCDS46 CQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLA 310 320 330 340 350 360 370 380 390 pF1KA0 CPDVLNLSLDSSDVERLERFFDSEDEDFEILSL ::::::::: : CCDS46 CPDVLNLSLGESCQVQILLM 370 380 >>CCDS14538.1 ATG4A gene_id:115201|Hs108|chrX (398 aa) initn: 1517 init1: 877 opt: 1507 Z-score: 1805.3 bits: 342.9 E(32554): 3.1e-94 Smith-Waterman score: 1507; 55.4% identity (81.4% similar) in 392 aa overlap (13-393:15-398) 10 20 30 40 50 pF1KA0 MDAATLTYDTLRFAEF-EDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKN :... :..:.:.: :::::... . :::...:::...:::::::.. CCDS14 MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KA0 FPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFID : ::::::.::.:::::::::::..::::.:::::::: : ..:.:: : .:. :.: CCDS14 FSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA0 RKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVME ::: :::::.::::::::::::.:.:::::::::::::.:: :.::::...::::::.: CCDS14 RKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA0 EIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAE---VTNRPSPWRPLVLLIPLRLGLTD .:...::. .: .. :: .:: ... :. . .. : :.::.:..:::::... CCDS14 DIKKMCRV-LPLSADTA----GDRPPDSLTASNQSKGTSAYCSAWKPLLLIVPLRLGINQ 190 200 210 220 230 240 250 260 270 280 290 pF1KA0 INEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFI :: .::...:.:: ::::::..:::::.:.::::..:.:::.::::::: :. .. . CCDS14 INPVYVDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTEENGTV 240 250 260 270 280 290 300 310 320 330 340 350 pF1KA0 PDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVEQ :..::: . : ::.: .::::.:.::::: : ::..::. :.: .: : :::::.. CCDS14 NDQTFHCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQK-EILKENLRMFELVQK 300 310 320 330 340 350 360 370 380 390 pF1KA0 QPSHL------ACPDVLNLSLDSSD-VERLERFFDSEDEDFEILSL .::: : :.: . . . : .:.::.: : : :::::::. CCDS14 HPSHWPPFVPPAKPEVTTTGAEFIDSTEQLEEF-DLE-EDFEILSV 360 370 380 390 >>CCDS14539.1 ATG4A gene_id:115201|Hs108|chrX (336 aa) initn: 1266 init1: 877 opt: 889 Z-score: 1066.4 bits: 205.9 E(32554): 4.4e-53 Smith-Waterman score: 1137; 48.1% identity (68.9% similar) in 389 aa overlap (13-393:15-336) 10 20 30 40 50 pF1KA0 MDAATLTYDTLRFAEF-EDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKN :... :..:.:.: :::::... . :::...:::...:::::::.. CCDS14 MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KA0 FPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFID : ::::::.::.:::::::::::..::::.:::::::: : ..:.:: : .:. :.: CCDS14 FSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA0 RKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVME ::: :::::.::::::::::::.:.:::::::::::::.:: :.::::...::::::.: CCDS14 RKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA0 EIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINE .:...::. .: ..: :: .:: CCDS14 DIKKMCRV---------LPLSADT------AG----DRP--------------------- 190 200 240 250 260 270 280 290 pF1KA0 AYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDE :.:: . :.. .:::.::::::: :. .. . :. CCDS14 ------------PDSLTA----SNQS--------DELIFLDPHTTQTFVDTEENGTVNDQ 210 220 230 300 310 320 330 340 350 pF1KA0 SFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVEQQPS .::: . : ::.: .::::.:.::::: : ::..::. :.: .: : :::::...:: CCDS14 TFHCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQK-EILKENLRMFELVQKHPS 240 250 260 270 280 290 360 370 380 390 pF1KA0 HL------ACPDVLNLSLDSSD-VERLERFFDSEDEDFEILSL : : :.: . . . : .:.::.: : : :::::::. CCDS14 HWPPFVPPAKPEVTTTGAEFIDSTEQLEEF-DLE-EDFEILSV 300 310 320 330 >>CCDS12241.1 ATG4D gene_id:84971|Hs108|chr19 (474 aa) initn: 565 init1: 249 opt: 588 Z-score: 703.9 bits: 139.3 E(32554): 6.9e-33 Smith-Waterman score: 656; 32.5% identity (55.6% similar) in 412 aa overlap (26-391:94-474) 10 20 30 40 50 pF1KA0 MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKD--EILSDVASRLWFT . . ::.: . : : .. : .::::.: CCDS12 KFKAKFLTAWNNVKYGWVVKSRTSFSKISSIHLCGRRYRFEGEGDIQRFQRDFVSRLWLT 70 80 90 100 110 120 60 70 80 90 100 pF1KA0 YRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQ------------- ::..:: . : ::: ::::::: :::..::.:. . : ::: :.. CCDS12 YRRDFPPLPGGCLTSDCGWGCMLRSGQMMLAQGLLLHFLPRDWTWAEGMGLGPPELSGSA 130 140 150 160 170 180 110 120 130 pF1KA0 ---RKRQPDSYF------------------SVLNAFIDRKDSYYSIHQIAQMGVGEGKSI : . : .. .... : :. . ...:.....: . ::. CCDS12 SPSRYHGPARWMPPRWAQGAPELEQERRHRQIVSWFADHPRAPFGLHRLVELGQSSGKKA 190 200 210 220 230 240 140 150 160 170 180 190 pF1KA0 GQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADS :.::::. ::..:.: ::. : : : . .: : :.. :: CCDS12 GDWYGPSLVAHILRK----------AVESCSDVT------RLVVYVSQDC---TVYKADV 250 260 270 280 200 210 220 230 240 250 pF1KA0 DRHCNGFPAGAEVTNRPSP---WRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVI : .. ::.: :. .:.:.:.::: .: .:: .:. . ::.. CCDS12 AR----------LVARPDPTAEWKSVVILVPVRLGGETLNPVYVPCVKELLRCELCLGIM 290 300 310 320 330 260 270 280 290 300 310 pF1KA0 GGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPS :::: . ::::: . :.::::: ::.:. ... : : ::::: : .:..:..::: CCDS12 GGKPRHSLYFIGYQDDFLLYLDPHYCQPTVDVSQADF-PLESFHCTSPR-KMAFAKMDPS 340 350 360 370 380 390 320 330 340 350 360 pF1KA0 IAVGFFCKTEDDFNDWCQQVKKLSLLGGAL---PMFELVE--QQPSHLA--CPDVLNLSL .:::. . .:. :... .. ..: ::: :.: : : : .. . .: CCDS12 CTVGFYAGDRKEFETLCSELTRVLSSSSATERYPMFTLAEGHAQDHSLDDLCSQLAQPTL 400 410 420 430 440 450 370 380 390 pF1KA0 DSSDVERLERFFDSEDEDFEILSL . :: : .::: .: CCDS12 RLPRTGRLLRAKRPSSEDFVFL 460 470 393 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 20:05:04 2016 done: Wed Nov 2 20:05:05 2016 Total Scan time: 2.900 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]