FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0950, 316 aa 1>>>pF1KA0950 316 - 316 aa - 316 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.9971+/-0.000795; mu= 9.6711+/- 0.048 mean_var=120.0480+/-24.567, 0's: 0 Z-trim(112.0): 8 B-trim: 0 in 0/51 Lambda= 0.117057 statistics sampled from 12826 (12832) to 12826 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.394), width: 16 Scan time: 2.620 The best scores are: opt bits E(32554) CCDS8791.1 FAIM2 gene_id:23017|Hs108|chr12 ( 316) 2116 367.7 6.7e-102 CCDS2412.1 TMBIM1 gene_id:64114|Hs108|chr2 ( 311) 984 176.5 2.3e-44 CCDS34961.1 GRINA gene_id:2907|Hs108|chr8 ( 371) 835 151.4 1e-36 CCDS41805.1 TMBIM4 gene_id:51643|Hs108|chr12 ( 238) 375 73.6 1.7e-13 CCDS61187.1 TMBIM4 gene_id:51643|Hs108|chr12 ( 285) 364 71.8 7.2e-13 >>CCDS8791.1 FAIM2 gene_id:23017|Hs108|chr12 (316 aa) initn: 2116 init1: 2116 opt: 2116 Z-score: 1942.9 bits: 367.7 E(32554): 6.7e-102 Smith-Waterman score: 2116; 100.0% identity (100.0% similar) in 316 aa overlap (1-316:1-316) 10 20 30 40 50 60 pF1KA0 MTQGKLSVANKAPGTEGQQQVHGEKKEAPAVPSAPPSYEEATSGEGMKAGAFPPAPTAVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS87 MTQGKLSVANKAPGTEGQQQVHGEKKEAPAVPSAPPSYEEATSGEGMKAGAFPPAPTAVP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LHPSWAYVDPSSSSSYDNGFPTGDHELFTTFSWDDQKVRRVFVRKVYTILLIQLLVTLAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS87 LHPSWAYVDPSSSSSYDNGFPTGDHELFTTFSWDDQKVRRVFVRKVYTILLIQLLVTLAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 VALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTVFTLSMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS87 VALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTVFTLSMA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 YLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVLFVLLMTLFFSGLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS87 YLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVLFVLLMTLFFSGLI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LAILLPFQYVPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYIFGALNIYLDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS87 LAILLPFQYVPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYIFGALNIYLDI 250 260 270 280 290 300 310 pF1KA0 IYIFTFFLQLFGTNRE :::::::::::::::: CCDS87 IYIFTFFLQLFGTNRE 310 >>CCDS2412.1 TMBIM1 gene_id:64114|Hs108|chr2 (311 aa) initn: 1023 init1: 935 opt: 984 Z-score: 909.9 bits: 176.5 E(32554): 2.3e-44 Smith-Waterman score: 987; 52.0% identity (74.0% similar) in 300 aa overlap (13-312:23-308) 10 20 30 40 50 pF1KA0 MTQGKLSVANKAPGTEGQQQVHGEKKEAPAVPSAPPSYEEATSGEGMKAG :: :: .: :. : :.: . : : :: CCDS24 MSNPSAPPPYEDRNPLYPGPPPPGGYGQPSV------LPGGYPAYPGYPQP--GYGHPAG 10 20 30 40 50 60 70 80 90 100 110 pF1KA0 AFPPAPTAVPLHPSWAYVDPSSSSSYDNGFPTGDHELFTTFSWDDQKVRRVFVRKVYTIL : : : :: :. .:: : . . : :::.:::..:.::::.:. CCDS24 YPQPMP---PTHPMPMNYGPGH--GYD-GEERAVSDSFGPGEWDDRKVRHTFIRKVYSII 60 70 80 90 100 120 130 140 150 160 170 pF1KA0 LIQLLVTLAVVALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLI .:::.:.:..:.::: .::. .:. : . :..::::: .::: ::::.::::.::::.: CCDS24 SVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNII 110 120 130 140 150 160 180 190 200 210 220 230 pF1KA0 LLTVFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVLFVL :::.::..:...:: .::.:.: .:.. . :::.: .:::.: :::: ::::: :.. :: CCDS24 LLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVL 170 180 190 200 210 220 240 250 260 270 280 290 pF1KA0 LMTLFFSGLILAILLPFQYVPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYI ..:. .:.. .:.: :::: ::: .:::::: :::::: ::::..:::.:..:::.:: CCDS24 GIVLLVTGIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYI 230 240 250 260 270 280 300 310 pF1KA0 FGALNIYLDIIYIFTFFLQLFGTNRE :::.:: :::::::: :::.: CCDS24 TGALQIYTDIIYIFTFVLQLMGDRN 290 300 310 >>CCDS34961.1 GRINA gene_id:2907|Hs108|chr8 (371 aa) initn: 813 init1: 546 opt: 835 Z-score: 772.7 bits: 151.4 E(32554): 1e-36 Smith-Waterman score: 835; 45.1% identity (75.3% similar) in 288 aa overlap (32-316:90-371) 10 20 30 40 50 60 pF1KA0 TQGKLSVANKAPGTEGQQQVHGEKKEAPAVPSAPPSYEEATSGEG-MKAGAFPPAPTAVP :..: : .. .: . . ::: : . : CCDS34 GPSPYPQGGYPQGPYPQGGYPQGPYPQEGYPQGP--YPQGGYPQGPYPQSPFPPNPYGQP 60 70 80 90 100 110 70 80 90 100 110 pF1KA0 -LHPSWAYVDPSSSSSYDNGFPTG-DHELFTTFSWDDQKVRRVFVRKVYTILLIQLLVTL . :. .:. .. ..: :. :.. : . .:::...:..:.:::. .: .:: ::: CCDS34 QVFPGQDPDSPQHGNYQEEGPPSYYDNQDFPATNWDDKSIRQAFIRKVFLVLTLQLSVTL 120 130 140 150 160 170 120 130 140 150 160 170 pF1KA0 AVVALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTVFTLS ..:..::: :: .:. : :..:::::: . ..:.::. ::. ::::. :.:.: : CCDS34 STVSVFTFVAEVKGFVRENVWTYYVSYAVFFISLIVLSCCGDFRRKHPWNLVALSVLTAS 180 190 200 210 220 230 180 190 200 210 220 230 pF1KA0 MAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVLFVLLMTLFFSG ..:..::..:.::: .:.. .:::. ::..:..::.::..:::::.:::.: ...:: CCDS34 LSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSMVVLF--- 240 250 260 270 280 290 240 250 260 270 280 290 pF1KA0 LILAILLPFQYVPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYIFGALNIYL :.::: : :. :::.::: .:: :::.:::::.::.. :::::::.:.:::.: CCDS34 -IFAILCIFIRNRILEIVYASLGALLFTCFLAVDTQLLLGNKQLSLSPEEYVFAALNLYT 300 310 320 330 340 350 300 310 pF1KA0 DIIYIFTFFLQLFGTNRE ::: :: ..: ..: .: CCDS34 DIINIFLYILTIIGRAKE 360 370 >>CCDS41805.1 TMBIM4 gene_id:51643|Hs108|chr12 (238 aa) initn: 342 init1: 135 opt: 375 Z-score: 355.7 bits: 73.6 E(32554): 1.7e-13 Smith-Waterman score: 375; 33.1% identity (62.9% similar) in 248 aa overlap (69-311:5-232) 40 50 60 70 80 90 pF1KA0 EEATSGEGMKAGAFPPAPTAVPLHPSWAYVDPS-SSSSYDNGFPTGDHELFTTFSWDDQK :: :: .. : :. .: . CCDS41 MADPDPRYPRSSIEDDFNYGSSVASATV-----H 10 20 100 110 120 130 140 150 pF1KA0 VRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVKDYVQANPG----WYWASYAVFFATYL .: .:.::::.:: .:.:.: .. ..: . . :. .:. .:. . .: ...:: : CCDS41 IRMAFLRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALIL 30 40 50 60 70 80 160 170 180 190 200 210 pF1KA0 TLACCSGPRRHFPWNLILLTVFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVFS . :...: :: :: ::: : .... ..:.. .: . .:. : ...::.. CCDS41 N-------RHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYIILQAFILTTTVFFGLTVYT 90 100 110 120 130 140 220 230 240 250 260 270 pF1KA0 FQTKFDFTSCQGVLFVLLMTLFFSGLILAILLPFQYVPWLHAVYAALGAGVFTLFLALDT .:.: ::.. . ::.:: : .::. : : : .. : :: :: .: :. :: CCDS41 LQSKKDFSKFGAGLFALLWILCLSGF----LKFFFYSEIMELVLAAAGALLFCGFIIYDT 150 160 170 180 190 280 290 300 310 pF1KA0 QLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE . :: :.::::::...:...::::: .: .:... CCDS41 HSLM----HKLSPEEYVLAAISLYLDIINLFLHLLRFLEAVNKK 200 210 220 230 >>CCDS61187.1 TMBIM4 gene_id:51643|Hs108|chr12 (285 aa) initn: 362 init1: 135 opt: 364 Z-score: 344.6 bits: 71.8 E(32554): 7.2e-13 Smith-Waterman score: 364; 34.6% identity (65.9% similar) in 214 aa overlap (102-311:81-279) 80 90 100 110 120 130 pF1KA0 SSSSYDNGFPTGDHELFTTFSWDDQKVRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVK :.::::.:: .:.:.: .. ..: . . :. CCDS61 PSATLNIIRFFHLRQSGRSGMVNIFYKGPTFLRKVYSILSLQVLLTTVTSTVFLYFESVR 60 70 80 90 100 110 140 150 160 170 180 pF1KA0 DYVQANPG----WYWASYAVFFATYLTLACCSGPRRHFPWNLILLTVFTLSMAYLTGMLS .:. .:. . .: ...:: :. :...: :: :: ::: : .... CCDS61 TFVHESPALILLFALGSLGLIFALILN-------RHKYPLNLYLLFGFTLLEALTVAVVV 120 130 140 150 160 190 200 210 220 230 240 pF1KA0 SYYNTTSVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVLFVLLMTLFFSGLILAILLPF ..:.. .: . .:. : ...::...:.: ::.. . ::.:: : .::. : : CCDS61 TFYDVYIILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILCLSGF----LKFF 170 180 190 200 210 250 260 270 280 290 300 pF1KA0 QYVPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFF : .. : :: :: .: :. ::. :: :.::::::...:...::::: .: . CCDS61 FYSEIMELVLAAAGALLFCGFIIYDTHSLM----HKLSPEEYVLAAISLYLDIINLFLHL 220 230 240 250 260 270 310 pF1KA0 LQLFGTNRE :... CCDS61 LRFLEAVNKK 280 316 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 01:12:00 2016 done: Fri Nov 4 01:12:00 2016 Total Scan time: 2.620 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]