Result of FASTA (omim) for
pF1KA0954
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0954, 1151 aa
1>>>pF1KA0954 1151 - 1151 aa - 1151 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 14.4121+/-0.000487; mu= -17.9717+/- 0.030
mean_var=670.6676+/-139.183, 0's: 0 Z-trim(123.3): 25 B-trim: 0 in 0/62
Lambda= 0.049525
statistics sampled from 42938 (42968) to 42938 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.774), E-opt: 0.2 (0.504), width: 16
Scan time: 18.980
The best scores are: opt bits E(85289)
NP_001120864 (OMIM: 608329) myelin regulatory fact (1151) 7902 580.8 1.7e-164
XP_005274279 (OMIM: 608329) PREDICTED: myelin regu (1152) 7872 578.6 7.4e-164
XP_005274281 (OMIM: 608329) PREDICTED: myelin regu (1146) 7857 577.6 1.5e-163
XP_005274280 (OMIM: 608329) PREDICTED: myelin regu (1147) 7827 575.4 6.8e-163
XP_005274285 (OMIM: 608329) PREDICTED: myelin regu (1101) 6468 478.3 1.1e-133
XP_011543536 (OMIM: 608329) PREDICTED: myelin regu ( 951) 6389 472.6 5.1e-132
XP_005274284 (OMIM: 608329) PREDICTED: myelin regu (1120) 5552 412.9 5.7e-114
XP_005274282 (OMIM: 608329) PREDICTED: myelin regu (1125) 5540 412.0 1e-113
XP_005274283 (OMIM: 608329) PREDICTED: myelin regu (1124) 5539 411.9 1.1e-113
NP_037411 (OMIM: 608329) myelin regulatory factor (1111) 5458 406.1 6e-112
>>NP_001120864 (OMIM: 608329) myelin regulatory factor i (1151 aa)
initn: 7902 init1: 7902 opt: 7902 Z-score: 3074.3 bits: 580.8 E(85289): 1.7e-164
Smith-Waterman score: 7902; 100.0% identity (100.0% similar) in 1151 aa overlap (1-1151:1-1151)
10 20 30 40 50 60
pF1KA0 MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 HGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 PIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRTITPETLCHVGVPSRLEHPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRTITPETLCHVGVPSRLEHPPP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 PPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 LQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 WATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 FSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 SDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 TEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 KTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 SGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSV
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 VSMSTLYVLSLRTEEDLVDTDGSFAVSTSCLLALLRPQPPGGSEALCPWSSQSFGTTQLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSMSTLYVLSLRTEEDLVDTDGSFAVSTSCLLALLRPQPPGGSEALCPWSSQSFGTTQLR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 QSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPSL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 GPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLAS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 PAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAEPVPSLTSIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAEPVPSLTSIQ
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 VLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRSK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 EEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPAT
1090 1100 1110 1120 1130 1140
1150
pF1KA0 DYHFHFYRLCD
:::::::::::
NP_001 DYHFHFYRLCD
1150
>>XP_005274279 (OMIM: 608329) PREDICTED: myelin regulato (1152 aa)
initn: 7873 init1: 5688 opt: 7872 Z-score: 3062.8 bits: 578.6 E(85289): 7.4e-164
Smith-Waterman score: 7872; 99.8% identity (99.8% similar) in 1152 aa overlap (1-1151:1-1152)
10 20 30 40 50 60
pF1KA0 MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 HGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 PIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRTITPETLCHVGVPSRLEHPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRTITPETLCHVGVPSRLEHPPP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 PPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 LQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 WATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 FSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 SDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 TEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 KTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 SGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSV
730 740 750 760 770 780
790 800 810 820 830
pF1KA0 VSMSTLYVLSLRTEEDLVDTDGSFAVSTSCLLALLRPQPPGGSEALCP-WSSQSFGTTQL
:::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
XP_005 VSMSTLYVLSLRTEEDLVDTDGSFAVSTSCLLALLRPQPPGGSEALCPCRSSQSFGTTQL
790 800 810 820 830 840
840 850 860 870 880 890
pF1KA0 RQSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPS
850 860 870 880 890 900
900 910 920 930 940 950
pF1KA0 LGPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLA
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KA0 SPAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAEPVPSLTSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAEPVPSLTSI
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KA0 QVLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QVLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRS
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KA0 KEEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPA
1090 1100 1110 1120 1130 1140
1140 1150
pF1KA0 TDYHFHFYRLCD
::::::::::::
XP_005 TDYHFHFYRLCD
1150
>>XP_005274281 (OMIM: 608329) PREDICTED: myelin regulato (1146 aa)
initn: 6907 init1: 6907 opt: 7857 Z-score: 3057.0 bits: 577.6 E(85289): 1.5e-163
Smith-Waterman score: 7857; 99.6% identity (99.6% similar) in 1151 aa overlap (1-1151:1-1146)
10 20 30 40 50 60
pF1KA0 MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 HGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 PIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRTITPETLCHVGVPSRLEHPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRTITPETLCHVGVPSRLEHPPP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 PPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 LQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 WATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 FSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 SDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 TEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 KTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 SGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSV
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 VSMSTLYVLSLRTEEDLVDTDGSFAVSTSCLLALLRPQPPGGSEALCPWSSQSFGTTQLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSMSTLYVLSLRTEEDLVDTDGSFAVSTSCLLALLRPQPPGGSEALCPWSSQSFGTTQLR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 QSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPSL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 GPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLAS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 PAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAEPVPSLTSIQ
::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
XP_005 PAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQS-----EPVPSLTSIQ
970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KA0 VLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRSK
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KA0 EEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPAT
1080 1090 1100 1110 1120 1130
1150
pF1KA0 DYHFHFYRLCD
:::::::::::
XP_005 DYHFHFYRLCD
1140
>>XP_005274280 (OMIM: 608329) PREDICTED: myelin regulato (1147 aa)
initn: 6878 init1: 5688 opt: 7827 Z-score: 3045.4 bits: 575.4 E(85289): 6.8e-163
Smith-Waterman score: 7827; 99.4% identity (99.4% similar) in 1152 aa overlap (1-1151:1-1147)
10 20 30 40 50 60
pF1KA0 MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 HGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 PIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRTITPETLCHVGVPSRLEHPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRTITPETLCHVGVPSRLEHPPP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 PPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 LQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 WATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 FSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 SDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 TEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 KTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 SGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSV
730 740 750 760 770 780
790 800 810 820 830
pF1KA0 VSMSTLYVLSLRTEEDLVDTDGSFAVSTSCLLALLRPQPPGGSEALCP-WSSQSFGTTQL
:::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
XP_005 VSMSTLYVLSLRTEEDLVDTDGSFAVSTSCLLALLRPQPPGGSEALCPCRSSQSFGTTQL
790 800 810 820 830 840
840 850 860 870 880 890
pF1KA0 RQSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPS
850 860 870 880 890 900
900 910 920 930 940 950
pF1KA0 LGPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLA
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KA0 SPAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAEPVPSLTSI
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::
XP_005 SPAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQS-----EPVPSLTSI
970 980 990 1000 1010
1020 1030 1040 1050 1060 1070
pF1KA0 QVLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QVLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRS
1020 1030 1040 1050 1060 1070
1080 1090 1100 1110 1120 1130
pF1KA0 KEEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPA
1080 1090 1100 1110 1120 1130
1140 1150
pF1KA0 TDYHFHFYRLCD
::::::::::::
XP_005 TDYHFHFYRLCD
1140
>>XP_005274285 (OMIM: 608329) PREDICTED: myelin regulato (1101 aa)
initn: 6411 init1: 4226 opt: 6468 Z-score: 2520.9 bits: 478.3 E(85289): 1.1e-133
Smith-Waterman score: 7357; 95.4% identity (95.4% similar) in 1152 aa overlap (1-1151:1-1101)
10 20 30 40 50 60
pF1KA0 MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 HGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 PIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRTITPETLCHVGVPSRLEHPPP
:::::::::::::::::::::::::::::::
XP_005 PIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQ-----------------------------
130 140 150
190 200 210 220 230 240
pF1KA0 PPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQL
::::::::::::::::::::::::::::::::::::::
XP_005 ----------------------RDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQL
160 170 180
250 260 270 280 290 300
pF1KA0 LQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQ
190 200 210 220 230 240
310 320 330 340 350 360
pF1KA0 GPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNK
250 260 270 280 290 300
370 380 390 400 410 420
pF1KA0 WATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTP
310 320 330 340 350 360
430 440 450 460 470 480
pF1KA0 EGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLH
370 380 390 400 410 420
490 500 510 520 530 540
pF1KA0 FSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESD
430 440 450 460 470 480
550 560 570 580 590 600
pF1KA0 SDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDT
490 500 510 520 530 540
610 620 630 640 650 660
pF1KA0 TEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANG
550 560 570 580 590 600
670 680 690 700 710 720
pF1KA0 KTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGS
610 620 630 640 650 660
730 740 750 760 770 780
pF1KA0 SGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSV
670 680 690 700 710 720
790 800 810 820 830
pF1KA0 VSMSTLYVLSLRTEEDLVDTDGSFAVSTSCLLALLRPQPPGGSEALCP-WSSQSFGTTQL
:::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
XP_005 VSMSTLYVLSLRTEEDLVDTDGSFAVSTSCLLALLRPQPPGGSEALCPCRSSQSFGTTQL
730 740 750 760 770 780
840 850 860 870 880 890
pF1KA0 RQSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPS
790 800 810 820 830 840
900 910 920 930 940 950
pF1KA0 LGPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLA
850 860 870 880 890 900
960 970 980 990 1000 1010
pF1KA0 SPAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAEPVPSLTSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAEPVPSLTSI
910 920 930 940 950 960
1020 1030 1040 1050 1060 1070
pF1KA0 QVLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QVLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRS
970 980 990 1000 1010 1020
1080 1090 1100 1110 1120 1130
pF1KA0 KEEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPA
1030 1040 1050 1060 1070 1080
1140 1150
pF1KA0 TDYHFHFYRLCD
::::::::::::
XP_005 TDYHFHFYRLCD
1090 1100
>>XP_011543536 (OMIM: 608329) PREDICTED: myelin regulato (951 aa)
initn: 6390 init1: 4205 opt: 6389 Z-score: 2491.2 bits: 472.6 E(85289): 5.1e-132
Smith-Waterman score: 6389; 99.8% identity (99.8% similar) in 950 aa overlap (203-1151:2-951)
180 190 200 210 220 230
pF1KA0 SRLEHPPPPPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQ
::::::::::::::::::::::::::::::
XP_011 MRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQ
10 20 30
240 250 260 270 280 290
pF1KA0 QSQMLHQLLQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSQMLHQLLQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRA
40 50 60 70 80 90
300 310 320 330 340 350
pF1KA0 PSPPWPPQGPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSPPWPPQGPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIK
100 110 120 130 140 150
360 370 380 390 400 410
pF1KA0 WQPHQQNKWATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WQPHQQNKWATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLG
160 170 180 190 200 210
420 430 440 450 460 470
pF1KA0 EPKYVKTPEGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPKYVKTPEGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVT
220 230 240 250 260 270
480 490 500 510 520 530
pF1KA0 KVTVGRLHFSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVTVGRLHFSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRAS
280 290 300 310 320 330
540 550 560 570 580 590
pF1KA0 NPGQFESDSDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPGQFESDSDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAK
340 350 360 370 380 390
600 610 620 630 640 650
pF1KA0 EHVQEVDTTEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EHVQEVDTTEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDT
400 410 420 430 440 450
660 670 680 690 700 710
pF1KA0 GDMVFANGKTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDMVFANGKTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRL
460 470 480 490 500 510
720 730 740 750 760 770
pF1KA0 DSLKSTGSSGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSLKSTGSSGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIAL
520 530 540 550 560 570
780 790 800 810 820 830
pF1KA0 VVVMAFSVVSMSTLYVLSLRTEEDLVDTDGSFAVSTSCLLALLRPQPPGGSEALCP-WSS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
XP_011 VVVMAFSVVSMSTLYVLSLRTEEDLVDTDGSFAVSTSCLLALLRPQPPGGSEALCPCRSS
580 590 600 610 620 630
840 850 860 870 880 890
pF1KA0 QSFGTTQLRQSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSFGTTQLRQSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPT
640 650 660 670 680 690
900 910 920 930 940 950
pF1KA0 TNPTTGPSLGPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNPTTGPSLGPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKH
700 710 720 730 740 750
960 970 980 990 1000 1010
pF1KA0 HKSLEPLASPAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HKSLEPLASPAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAE
760 770 780 790 800 810
1020 1030 1040 1050 1060 1070
pF1KA0 PVPSLTSIQVLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVPSLTSIQVLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVS
820 830 840 850 860 870
1080 1090 1100 1110 1120 1130
pF1KA0 VVLCSLRSKEEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVLCSLRSKEEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCS
880 890 900 910 920 930
1140 1150
pF1KA0 SEALAQPATDYHFHFYRLCD
::::::::::::::::::::
XP_011 SEALAQPATDYHFHFYRLCD
940 950
>>XP_005274284 (OMIM: 608329) PREDICTED: myelin regulato (1120 aa)
initn: 6698 init1: 5508 opt: 5552 Z-score: 2167.1 bits: 412.9 E(85289): 5.7e-114
Smith-Waterman score: 7599; 97.2% identity (97.2% similar) in 1151 aa overlap (1-1151:1-1120)
10 20 30 40 50 60
pF1KA0 MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 HGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 PIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRTITPETLCHVGVPSRLEHPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRTITPETLCHVGVPSRLEHPPP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 PPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 LQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 WATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 FSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 SDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 TEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 KTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 SGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSV
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 VSMSTLYVLSLRTEEDLVDTDGSFAVSTSCLLALLRPQPPGGSEALCPWSSQSFGTTQLR
:::::::::::::::::::::: :::::::::::
XP_005 VSMSTLYVLSLRTEEDLVDTDGR--------------------------SSQSFGTTQLR
790 800 810
850 860 870 880 890 900
pF1KA0 QSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPSL
820 830 840 850 860 870
910 920 930 940 950 960
pF1KA0 GPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLAS
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KA0 PAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAEPVPSLTSIQ
::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
XP_005 PAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQS-----EPVPSLTSIQ
940 950 960 970 980
1030 1040 1050 1060 1070 1080
pF1KA0 VLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRSK
990 1000 1010 1020 1030 1040
1090 1100 1110 1120 1130 1140
pF1KA0 EEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPAT
1050 1060 1070 1080 1090 1100
1150
pF1KA0 DYHFHFYRLCD
:::::::::::
XP_005 DYHFHFYRLCD
1110 1120
>>XP_005274282 (OMIM: 608329) PREDICTED: myelin regulato (1125 aa)
initn: 7693 init1: 5508 opt: 5540 Z-score: 2162.4 bits: 412.0 E(85289): 1e-113
Smith-Waterman score: 7644; 97.7% identity (97.7% similar) in 1151 aa overlap (1-1151:1-1125)
10 20 30 40 50 60
pF1KA0 MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 HGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 PIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRTITPETLCHVGVPSRLEHPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRTITPETLCHVGVPSRLEHPPP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 PPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 LQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 WATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 FSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 SDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 TEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 KTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 SGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSV
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 VSMSTLYVLSLRTEEDLVDTDGSFAVSTSCLLALLRPQPPGGSEALCPWSSQSFGTTQLR
:::::::::::::::::::::: :::::::::::
XP_005 VSMSTLYVLSLRTEEDLVDTDGR--------------------------SSQSFGTTQLR
790 800 810
850 860 870 880 890 900
pF1KA0 QSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPSL
820 830 840 850 860 870
910 920 930 940 950 960
pF1KA0 GPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLAS
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KA0 PAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAEPVPSLTSIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAEPVPSLTSIQ
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KA0 VLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRSK
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KA0 EEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPAT
1060 1070 1080 1090 1100 1110
1150
pF1KA0 DYHFHFYRLCD
:::::::::::
XP_005 DYHFHFYRLCD
1120
>>XP_005274283 (OMIM: 608329) PREDICTED: myelin regulato (1124 aa)
initn: 5513 init1: 5513 opt: 5539 Z-score: 2162.0 bits: 411.9 E(85289): 1.1e-113
Smith-Waterman score: 7643; 97.7% identity (97.7% similar) in 1151 aa overlap (1-1151:1-1124)
10 20 30 40 50 60
pF1KA0 MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 HGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 PIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRTITPETLCHVGVPSRLEHPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRTITPETLCHVGVPSRLEHPPP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 PPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 LQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 WATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 FSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 SDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 TEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 KTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 SGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSV
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 VSMSTLYVLSLRTEEDLVDTDGSFAVSTSCLLALLRPQPPGGSEALCPWSSQSFGTTQLR
::::::::::::::::::::::: ::::::::::
XP_005 VSMSTLYVLSLRTEEDLVDTDGS---------------------------SQSFGTTQLR
790 800 810
850 860 870 880 890 900
pF1KA0 QSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPSL
820 830 840 850 860 870
910 920 930 940 950 960
pF1KA0 GPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLAS
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KA0 PAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAEPVPSLTSIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAEPVPSLTSIQ
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KA0 VLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRSK
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KA0 EEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPAT
1060 1070 1080 1090 1100 1110
1150
pF1KA0 DYHFHFYRLCD
:::::::::::
XP_005 DYHFHFYRLCD
1120
>>NP_037411 (OMIM: 608329) myelin regulatory factor isof (1111 aa)
initn: 6604 init1: 5414 opt: 5458 Z-score: 2130.8 bits: 406.1 E(85289): 6e-112
Smith-Waterman score: 7505; 97.2% identity (97.2% similar) in 1136 aa overlap (16-1151:7-1111)
10 20 30 40 50 60
pF1KA0 MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYS
:::::::::::::::::::::::::::::::::::::::::::::
NP_037 MHWLPAGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYS
10 20 30 40 50
70 80 90 100 110 120
pF1KA0 HGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 HGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGP
60 70 80 90 100 110
130 140 150 160 170 180
pF1KA0 PIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRTITPETLCHVGVPSRLEHPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 PIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRTITPETLCHVGVPSRLEHPPP
120 130 140 150 160 170
190 200 210 220 230 240
pF1KA0 PPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 PPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KA0 LQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 LQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQ
240 250 260 270 280 290
310 320 330 340 350 360
pF1KA0 GPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 GPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNK
300 310 320 330 340 350
370 380 390 400 410 420
pF1KA0 WATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 WATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTP
360 370 380 390 400 410
430 440 450 460 470 480
pF1KA0 EGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 EGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLH
420 430 440 450 460 470
490 500 510 520 530 540
pF1KA0 FSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 FSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESD
480 490 500 510 520 530
550 560 570 580 590 600
pF1KA0 SDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 SDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDT
540 550 560 570 580 590
610 620 630 640 650 660
pF1KA0 TEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 TEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANG
600 610 620 630 640 650
670 680 690 700 710 720
pF1KA0 KTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 KTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGS
660 670 680 690 700 710
730 740 750 760 770 780
pF1KA0 SGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 SGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSV
720 730 740 750 760 770
790 800 810 820 830 840
pF1KA0 VSMSTLYVLSLRTEEDLVDTDGSFAVSTSCLLALLRPQPPGGSEALCPWSSQSFGTTQLR
:::::::::::::::::::::: :::::::::::
NP_037 VSMSTLYVLSLRTEEDLVDTDGR--------------------------SSQSFGTTQLR
780 790 800
850 860 870 880 890 900
pF1KA0 QSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 QSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPSL
810 820 830 840 850 860
910 920 930 940 950 960
pF1KA0 GPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 GPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLAS
870 880 890 900 910 920
970 980 990 1000 1010 1020
pF1KA0 PAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAEPVPSLTSIQ
::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
NP_037 PAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQS-----EPVPSLTSIQ
930 940 950 960 970 980
1030 1040 1050 1060 1070 1080
pF1KA0 VLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 VLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRSK
990 1000 1010 1020 1030 1040
1090 1100 1110 1120 1130 1140
pF1KA0 EEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 EEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPAT
1050 1060 1070 1080 1090 1100
1150
pF1KA0 DYHFHFYRLCD
:::::::::::
NP_037 DYHFHFYRLCD
1110
1151 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 10:35:14 2016 done: Thu Nov 3 10:35:17 2016
Total Scan time: 18.980 Total Display time: 0.640
Function used was FASTA [36.3.4 Apr, 2011]