FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0983, 683 aa 1>>>pF1KA0983 683 - 683 aa - 683 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4284+/-0.000407; mu= 15.2740+/- 0.025 mean_var=121.5232+/-24.300, 0's: 0 Z-trim(115.1): 34 B-trim: 0 in 0/56 Lambda= 0.116344 statistics sampled from 25359 (25390) to 25359 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.298), width: 16 Scan time: 11.090 The best scores are: opt bits E(85289) NP_003669 (OMIM: 612733) THO complex subunit 5 hom ( 683) 4559 777.0 0 NP_001002879 (OMIM: 612733) THO complex subunit 5 ( 683) 4559 777.0 0 NP_001002878 (OMIM: 612733) THO complex subunit 5 ( 683) 4559 777.0 0 NP_001002877 (OMIM: 612733) THO complex subunit 5 ( 683) 4559 777.0 0 XP_006724410 (OMIM: 612733) PREDICTED: THO complex ( 694) 2701 465.2 3.8e-130 XP_005261854 (OMIM: 612733) PREDICTED: THO complex ( 694) 2701 465.2 3.8e-130 XP_005261855 (OMIM: 612733) PREDICTED: THO complex ( 694) 2701 465.2 3.8e-130 XP_005261856 (OMIM: 612733) PREDICTED: THO complex ( 694) 2701 465.2 3.8e-130 XP_016884516 (OMIM: 612733) PREDICTED: THO complex ( 694) 2701 465.2 3.8e-130 XP_005261858 (OMIM: 612733) PREDICTED: THO complex ( 344) 2337 403.8 5.5e-112 >>NP_003669 (OMIM: 612733) THO complex subunit 5 homolog (683 aa) initn: 4559 init1: 4559 opt: 4559 Z-score: 4143.1 bits: 777.0 E(85289): 0 Smith-Waterman score: 4559; 99.9% identity (100.0% similar) in 683 aa overlap (1-683:1-683) 10 20 30 40 50 60 pF1KA0 MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAIEGSVDEAKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAIEGSVDEAKAL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 FKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 HLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 HLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 QFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSASHMETTMKLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSASHMETTMKLLK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 TRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTIAHEDYMELHFTKDIV ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: NP_003 TRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYMELHFTKDIV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 DAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 MEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLR 610 620 630 640 650 660 670 680 pF1KA0 LFRGPSRMKPFKYNHPQGFFSHR ::::::::::::::::::::::: NP_003 LFRGPSRMKPFKYNHPQGFFSHR 670 680 >>NP_001002879 (OMIM: 612733) THO complex subunit 5 homo (683 aa) initn: 4559 init1: 4559 opt: 4559 Z-score: 4143.1 bits: 777.0 E(85289): 0 Smith-Waterman score: 4559; 99.9% identity (100.0% similar) in 683 aa overlap (1-683:1-683) 10 20 30 40 50 60 pF1KA0 MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAIEGSVDEAKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAIEGSVDEAKAL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 FKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 HLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 QFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSASHMETTMKLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSASHMETTMKLLK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 TRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTIAHEDYMELHFTKDIV ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: NP_001 TRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYMELHFTKDIV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 DAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 MEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLR 610 620 630 640 650 660 670 680 pF1KA0 LFRGPSRMKPFKYNHPQGFFSHR ::::::::::::::::::::::: NP_001 LFRGPSRMKPFKYNHPQGFFSHR 670 680 >>NP_001002878 (OMIM: 612733) THO complex subunit 5 homo (683 aa) initn: 4559 init1: 4559 opt: 4559 Z-score: 4143.1 bits: 777.0 E(85289): 0 Smith-Waterman score: 4559; 99.9% identity (100.0% similar) in 683 aa overlap (1-683:1-683) 10 20 30 40 50 60 pF1KA0 MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAIEGSVDEAKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAIEGSVDEAKAL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 FKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 HLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 QFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSASHMETTMKLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSASHMETTMKLLK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 TRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTIAHEDYMELHFTKDIV ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: NP_001 TRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYMELHFTKDIV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 DAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 MEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLR 610 620 630 640 650 660 670 680 pF1KA0 LFRGPSRMKPFKYNHPQGFFSHR ::::::::::::::::::::::: NP_001 LFRGPSRMKPFKYNHPQGFFSHR 670 680 >>NP_001002877 (OMIM: 612733) THO complex subunit 5 homo (683 aa) initn: 4559 init1: 4559 opt: 4559 Z-score: 4143.1 bits: 777.0 E(85289): 0 Smith-Waterman score: 4559; 99.9% identity (100.0% similar) in 683 aa overlap (1-683:1-683) 10 20 30 40 50 60 pF1KA0 MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAIEGSVDEAKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAIEGSVDEAKAL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 FKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 HLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 QFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSASHMETTMKLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSASHMETTMKLLK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 TRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTIAHEDYMELHFTKDIV ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: NP_001 TRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYMELHFTKDIV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 DAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 MEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLR 610 620 630 640 650 660 670 680 pF1KA0 LFRGPSRMKPFKYNHPQGFFSHR ::::::::::::::::::::::: NP_001 LFRGPSRMKPFKYNHPQGFFSHR 670 680 >>XP_006724410 (OMIM: 612733) PREDICTED: THO complex sub (694 aa) initn: 4545 init1: 2701 opt: 2701 Z-score: 2457.6 bits: 465.2 E(85289): 3.8e-130 Smith-Waterman score: 4527; 98.3% identity (98.4% similar) in 694 aa overlap (1-683:1-694) 10 20 30 40 50 60 pF1KA0 MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS 190 200 210 220 230 240 250 260 270 280 pF1KA0 LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQAC-----------DKTLSVA :::::::::::::::::::::::::::::::::::::::::: ::::::: XP_006 LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACAHMKSSQPPRQDKTLSVA 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA0 IEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVM 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA0 LDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDH 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA0 GKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSA 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA0 SHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTIAHED :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: XP_006 SHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHED 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA0 YMELHFTKDIVDAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YMELHFTKDIVDAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGE 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA0 KTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGP 610 620 630 640 650 660 650 660 670 680 pF1KA0 KEFPQEKMCLRLFRGPSRMKPFKYNHPQGFFSHR :::::::::::::::::::::::::::::::::: XP_006 KEFPQEKMCLRLFRGPSRMKPFKYNHPQGFFSHR 670 680 690 >>XP_005261854 (OMIM: 612733) PREDICTED: THO complex sub (694 aa) initn: 4545 init1: 2701 opt: 2701 Z-score: 2457.6 bits: 465.2 E(85289): 3.8e-130 Smith-Waterman score: 4527; 98.3% identity (98.4% similar) in 694 aa overlap (1-683:1-694) 10 20 30 40 50 60 pF1KA0 MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS 190 200 210 220 230 240 250 260 270 280 pF1KA0 LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQAC-----------DKTLSVA :::::::::::::::::::::::::::::::::::::::::: ::::::: XP_005 LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACAHMKSSQPPRQDKTLSVA 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA0 IEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVM 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA0 LDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDH 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA0 GKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSA 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA0 SHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTIAHED :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: XP_005 SHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHED 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA0 YMELHFTKDIVDAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YMELHFTKDIVDAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGE 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA0 KTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGP 610 620 630 640 650 660 650 660 670 680 pF1KA0 KEFPQEKMCLRLFRGPSRMKPFKYNHPQGFFSHR :::::::::::::::::::::::::::::::::: XP_005 KEFPQEKMCLRLFRGPSRMKPFKYNHPQGFFSHR 670 680 690 >>XP_005261855 (OMIM: 612733) PREDICTED: THO complex sub (694 aa) initn: 4545 init1: 2701 opt: 2701 Z-score: 2457.6 bits: 465.2 E(85289): 3.8e-130 Smith-Waterman score: 4527; 98.3% identity (98.4% similar) in 694 aa overlap (1-683:1-694) 10 20 30 40 50 60 pF1KA0 MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS 190 200 210 220 230 240 250 260 270 280 pF1KA0 LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQAC-----------DKTLSVA :::::::::::::::::::::::::::::::::::::::::: ::::::: XP_005 LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACAHMKSSQPPRQDKTLSVA 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA0 IEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVM 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA0 LDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDH 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA0 GKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSA 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA0 SHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTIAHED :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: XP_005 SHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHED 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA0 YMELHFTKDIVDAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YMELHFTKDIVDAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGE 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA0 KTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGP 610 620 630 640 650 660 650 660 670 680 pF1KA0 KEFPQEKMCLRLFRGPSRMKPFKYNHPQGFFSHR :::::::::::::::::::::::::::::::::: XP_005 KEFPQEKMCLRLFRGPSRMKPFKYNHPQGFFSHR 670 680 690 >>XP_005261856 (OMIM: 612733) PREDICTED: THO complex sub (694 aa) initn: 4545 init1: 2701 opt: 2701 Z-score: 2457.6 bits: 465.2 E(85289): 3.8e-130 Smith-Waterman score: 4527; 98.3% identity (98.4% similar) in 694 aa overlap (1-683:1-694) 10 20 30 40 50 60 pF1KA0 MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS 190 200 210 220 230 240 250 260 270 280 pF1KA0 LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQAC-----------DKTLSVA :::::::::::::::::::::::::::::::::::::::::: ::::::: XP_005 LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACAHMKSSQPPRQDKTLSVA 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA0 IEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVM 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA0 LDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDH 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA0 GKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSA 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA0 SHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTIAHED :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: XP_005 SHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHED 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA0 YMELHFTKDIVDAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YMELHFTKDIVDAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGE 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA0 KTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGP 610 620 630 640 650 660 650 660 670 680 pF1KA0 KEFPQEKMCLRLFRGPSRMKPFKYNHPQGFFSHR :::::::::::::::::::::::::::::::::: XP_005 KEFPQEKMCLRLFRGPSRMKPFKYNHPQGFFSHR 670 680 690 >>XP_016884516 (OMIM: 612733) PREDICTED: THO complex sub (694 aa) initn: 4545 init1: 2701 opt: 2701 Z-score: 2457.6 bits: 465.2 E(85289): 3.8e-130 Smith-Waterman score: 4527; 98.3% identity (98.4% similar) in 694 aa overlap (1-683:1-694) 10 20 30 40 50 60 pF1KA0 MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS 190 200 210 220 230 240 250 260 270 280 pF1KA0 LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQAC-----------DKTLSVA :::::::::::::::::::::::::::::::::::::::::: ::::::: XP_016 LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACAHMKSSQPPRQDKTLSVA 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA0 IEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVM 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA0 LDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDH 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA0 GKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSA 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA0 SHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTIAHED :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: XP_016 SHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHED 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA0 YMELHFTKDIVDAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YMELHFTKDIVDAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGE 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA0 KTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGP 610 620 630 640 650 660 650 660 670 680 pF1KA0 KEFPQEKMCLRLFRGPSRMKPFKYNHPQGFFSHR :::::::::::::::::::::::::::::::::: XP_016 KEFPQEKMCLRLFRGPSRMKPFKYNHPQGFFSHR 670 680 690 >>XP_005261858 (OMIM: 612733) PREDICTED: THO complex sub (344 aa) initn: 2337 init1: 2337 opt: 2337 Z-score: 2131.5 bits: 403.8 E(85289): 5.5e-112 Smith-Waterman score: 2337; 99.7% identity (100.0% similar) in 344 aa overlap (340-683:1-344) 310 320 330 340 350 360 pF1KA0 DESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVLHLTFYYLMN :::::::::::::::::::::::::::::: XP_005 MLKRHPLSVMLDLKCKDDSVLHLTFYYLMN 10 20 30 370 380 390 400 410 420 pF1KA0 LNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILT 40 50 60 70 80 90 430 440 450 460 470 480 pF1KA0 LSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSASHMETTMKLLKTRVQSRLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSASHMETTMKLLKTRVQSRLAL 100 110 120 130 140 150 490 500 510 520 530 540 pF1KA0 HKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTIAHEDYMELHFTKDIVDAGLAGDTN :::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::: XP_005 HKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYMELHFTKDIVDAGLAGDTN 160 170 180 190 200 210 550 560 570 580 590 600 pF1KA0 LYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCY 220 230 240 250 260 270 610 620 630 640 650 660 pF1KA0 KELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLRLFRGPSRMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLRLFRGPSRMK 280 290 300 310 320 330 670 680 pF1KA0 PFKYNHPQGFFSHR :::::::::::::: XP_005 PFKYNHPQGFFSHR 340 683 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 01:14:11 2016 done: Fri Nov 4 01:14:12 2016 Total Scan time: 11.090 Total Display time: 0.160 Function used was FASTA [36.3.4 Apr, 2011]