Result of FASTA (omim) for
pF1KA0984
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0984, 647 aa
1>>>pF1KA0984 647 - 647 aa - 647 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.7073+/-0.000371; mu= 8.7658+/- 0.023
mean_var=148.7869+/-31.917, 0's: 0 Z-trim(117.5): 67 B-trim: 1247 in 1/60
Lambda= 0.105146
statistics sampled from 29540 (29626) to 29540 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.706), E-opt: 0.2 (0.347), width: 16
Scan time: 11.080
The best scores are: opt bits E(85289)
NP_001317116 (OMIM: 615077) TBC1 domain family mem ( 647) 4332 669.3 1.2e-191
NP_001317117 (OMIM: 615077) TBC1 domain family mem ( 647) 4332 669.3 1.2e-191
XP_016874576 (OMIM: 615077) PREDICTED: TBC1 domain ( 647) 4332 669.3 1.2e-191
NP_056094 (OMIM: 615077) TBC1 domain family member ( 761) 4332 669.3 1.4e-191
NP_001317115 (OMIM: 615077) TBC1 domain family mem ( 737) 2564 401.1 7.3e-111
XP_016874573 (OMIM: 615077) PREDICTED: TBC1 domain ( 667) 2559 400.3 1.1e-110
XP_011536380 (OMIM: 615077) PREDICTED: TBC1 domain ( 781) 2559 400.4 1.3e-110
NP_060891 (OMIM: 609871) TBC1 domain family member ( 917) 257 51.2 1.9e-05
>>NP_001317116 (OMIM: 615077) TBC1 domain family member (647 aa)
initn: 4332 init1: 4332 opt: 4332 Z-score: 3561.6 bits: 669.3 E(85289): 1.2e-191
Smith-Waterman score: 4332; 100.0% identity (100.0% similar) in 647 aa overlap (1-647:1-647)
10 20 30 40 50 60
pF1KA0 MRFTFNERSNPDDDSMGIQIVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRFTFNERSNPDDDSMGIQIVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 CQGFNILAALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CQGFNILAALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 LPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 SEIILRVSLAIWAKLGEQIECCETADEFYSTMGRLTQEMLENDLLQSHELMQTVYSMAPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEIILRVSLAIWAKLGEQIECCETADEFYSTMGRLTQEMLENDLLQSHELMQTVYSMAPF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PFPQLAELREKYTYNITPFPATVKPTSVSGRHSKARDSDEENDPDDEDAVVNAVGCLGPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFPQLAELREKYTYNITPFPATVKPTSVSGRHSKARDSDEENDPDDEDAVVNAVGCLGPF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 SGFLAPELQKYQKQIKEPNEEQSLRSNNIAELSPGAINSCRSEYHAAFNSMMMERMTTDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGFLAPELQKYQKQIKEPNEEQSLRSNNIAELSPGAINSCRSEYHAAFNSMMMERMTTDI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 NALKRQYSRIKKKQQQQVHQVYIRADKGPVTSILPSQVNSSPVINHLLLGKKMKMTNRAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NALKRQYSRIKKKQQQQVHQVYIRADKGPVTSILPSQVNSSPVINHLLLGKKMKMTNRAA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 KNAVIHIPGHTGGKISPVPYEDLKTKLNSPWRTHIRVHKKNMPRTKSHPGCGDTVGLIDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNAVIHIPGHTGGKISPVPYEDLKTKLNSPWRTHIRVHKKNMPRTKSHPGCGDTVGLIDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 QNEASKTNGLGAAEAFPSGCTATAGREGSSPEGSTRRTIEGQSPEPVFGDADVDVSAVQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QNEASKTNGLGAAEAFPSGCTATAGREGSSPEGSTRRTIEGQSPEPVFGDADVDVSAVQA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 KLGALELNQRDAAAETELRVHPPCQRHCPEPPSAPEENKATSKAPQGSNSKTPIFSPFPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLGALELNQRDAAAETELRVHPPCQRHCPEPPSAPEENKATSKAPQGSNSKTPIFSPFPS
550 560 570 580 590 600
610 620 630 640
pF1KA0 VKPLRKSATARNLGLYGPTERTPTVHFPQMSRSFSKPGGGNSGTKKR
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKPLRKSATARNLGLYGPTERTPTVHFPQMSRSFSKPGGGNSGTKKR
610 620 630 640
>>NP_001317117 (OMIM: 615077) TBC1 domain family member (647 aa)
initn: 4332 init1: 4332 opt: 4332 Z-score: 3561.6 bits: 669.3 E(85289): 1.2e-191
Smith-Waterman score: 4332; 100.0% identity (100.0% similar) in 647 aa overlap (1-647:1-647)
10 20 30 40 50 60
pF1KA0 MRFTFNERSNPDDDSMGIQIVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRFTFNERSNPDDDSMGIQIVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 CQGFNILAALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CQGFNILAALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 LPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 SEIILRVSLAIWAKLGEQIECCETADEFYSTMGRLTQEMLENDLLQSHELMQTVYSMAPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEIILRVSLAIWAKLGEQIECCETADEFYSTMGRLTQEMLENDLLQSHELMQTVYSMAPF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PFPQLAELREKYTYNITPFPATVKPTSVSGRHSKARDSDEENDPDDEDAVVNAVGCLGPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFPQLAELREKYTYNITPFPATVKPTSVSGRHSKARDSDEENDPDDEDAVVNAVGCLGPF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 SGFLAPELQKYQKQIKEPNEEQSLRSNNIAELSPGAINSCRSEYHAAFNSMMMERMTTDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGFLAPELQKYQKQIKEPNEEQSLRSNNIAELSPGAINSCRSEYHAAFNSMMMERMTTDI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 NALKRQYSRIKKKQQQQVHQVYIRADKGPVTSILPSQVNSSPVINHLLLGKKMKMTNRAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NALKRQYSRIKKKQQQQVHQVYIRADKGPVTSILPSQVNSSPVINHLLLGKKMKMTNRAA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 KNAVIHIPGHTGGKISPVPYEDLKTKLNSPWRTHIRVHKKNMPRTKSHPGCGDTVGLIDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNAVIHIPGHTGGKISPVPYEDLKTKLNSPWRTHIRVHKKNMPRTKSHPGCGDTVGLIDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 QNEASKTNGLGAAEAFPSGCTATAGREGSSPEGSTRRTIEGQSPEPVFGDADVDVSAVQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QNEASKTNGLGAAEAFPSGCTATAGREGSSPEGSTRRTIEGQSPEPVFGDADVDVSAVQA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 KLGALELNQRDAAAETELRVHPPCQRHCPEPPSAPEENKATSKAPQGSNSKTPIFSPFPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLGALELNQRDAAAETELRVHPPCQRHCPEPPSAPEENKATSKAPQGSNSKTPIFSPFPS
550 560 570 580 590 600
610 620 630 640
pF1KA0 VKPLRKSATARNLGLYGPTERTPTVHFPQMSRSFSKPGGGNSGTKKR
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKPLRKSATARNLGLYGPTERTPTVHFPQMSRSFSKPGGGNSGTKKR
610 620 630 640
>>XP_016874576 (OMIM: 615077) PREDICTED: TBC1 domain fam (647 aa)
initn: 4332 init1: 4332 opt: 4332 Z-score: 3561.6 bits: 669.3 E(85289): 1.2e-191
Smith-Waterman score: 4332; 100.0% identity (100.0% similar) in 647 aa overlap (1-647:1-647)
10 20 30 40 50 60
pF1KA0 MRFTFNERSNPDDDSMGIQIVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRFTFNERSNPDDDSMGIQIVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 CQGFNILAALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CQGFNILAALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 LPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 SEIILRVSLAIWAKLGEQIECCETADEFYSTMGRLTQEMLENDLLQSHELMQTVYSMAPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEIILRVSLAIWAKLGEQIECCETADEFYSTMGRLTQEMLENDLLQSHELMQTVYSMAPF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PFPQLAELREKYTYNITPFPATVKPTSVSGRHSKARDSDEENDPDDEDAVVNAVGCLGPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFPQLAELREKYTYNITPFPATVKPTSVSGRHSKARDSDEENDPDDEDAVVNAVGCLGPF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 SGFLAPELQKYQKQIKEPNEEQSLRSNNIAELSPGAINSCRSEYHAAFNSMMMERMTTDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGFLAPELQKYQKQIKEPNEEQSLRSNNIAELSPGAINSCRSEYHAAFNSMMMERMTTDI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 NALKRQYSRIKKKQQQQVHQVYIRADKGPVTSILPSQVNSSPVINHLLLGKKMKMTNRAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NALKRQYSRIKKKQQQQVHQVYIRADKGPVTSILPSQVNSSPVINHLLLGKKMKMTNRAA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 KNAVIHIPGHTGGKISPVPYEDLKTKLNSPWRTHIRVHKKNMPRTKSHPGCGDTVGLIDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNAVIHIPGHTGGKISPVPYEDLKTKLNSPWRTHIRVHKKNMPRTKSHPGCGDTVGLIDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 QNEASKTNGLGAAEAFPSGCTATAGREGSSPEGSTRRTIEGQSPEPVFGDADVDVSAVQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNEASKTNGLGAAEAFPSGCTATAGREGSSPEGSTRRTIEGQSPEPVFGDADVDVSAVQA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 KLGALELNQRDAAAETELRVHPPCQRHCPEPPSAPEENKATSKAPQGSNSKTPIFSPFPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLGALELNQRDAAAETELRVHPPCQRHCPEPPSAPEENKATSKAPQGSNSKTPIFSPFPS
550 560 570 580 590 600
610 620 630 640
pF1KA0 VKPLRKSATARNLGLYGPTERTPTVHFPQMSRSFSKPGGGNSGTKKR
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKPLRKSATARNLGLYGPTERTPTVHFPQMSRSFSKPGGGNSGTKKR
610 620 630 640
>>NP_056094 (OMIM: 615077) TBC1 domain family member 30 (761 aa)
initn: 4332 init1: 4332 opt: 4332 Z-score: 3560.6 bits: 669.3 E(85289): 1.4e-191
Smith-Waterman score: 4332; 100.0% identity (100.0% similar) in 647 aa overlap (1-647:115-761)
10 20 30
pF1KA0 MRFTFNERSNPDDDSMGIQIVKDLHRTGCS
::::::::::::::::::::::::::::::
NP_056 TGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQIVKDLHRTGCS
90 100 110 120 130 140
40 50 60 70 80 90
pF1KA0 SYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIYLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIYLI
150 160 170 180 190 200
100 110 120 130 140 150
pF1KA0 DKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTNV
210 220 230 240 250 260
160 170 180 190 200 210
pF1KA0 FTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADEFYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 FTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADEFYS
270 280 290 300 310 320
220 230 240 250 260 270
pF1KA0 TMGRLTQEMLENDLLQSHELMQTVYSMAPFPFPQLAELREKYTYNITPFPATVKPTSVSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TMGRLTQEMLENDLLQSHELMQTVYSMAPFPFPQLAELREKYTYNITPFPATVKPTSVSG
330 340 350 360 370 380
280 290 300 310 320 330
pF1KA0 RHSKARDSDEENDPDDEDAVVNAVGCLGPFSGFLAPELQKYQKQIKEPNEEQSLRSNNIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 RHSKARDSDEENDPDDEDAVVNAVGCLGPFSGFLAPELQKYQKQIKEPNEEQSLRSNNIA
390 400 410 420 430 440
340 350 360 370 380 390
pF1KA0 ELSPGAINSCRSEYHAAFNSMMMERMTTDINALKRQYSRIKKKQQQQVHQVYIRADKGPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ELSPGAINSCRSEYHAAFNSMMMERMTTDINALKRQYSRIKKKQQQQVHQVYIRADKGPV
450 460 470 480 490 500
400 410 420 430 440 450
pF1KA0 TSILPSQVNSSPVINHLLLGKKMKMTNRAAKNAVIHIPGHTGGKISPVPYEDLKTKLNSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TSILPSQVNSSPVINHLLLGKKMKMTNRAAKNAVIHIPGHTGGKISPVPYEDLKTKLNSP
510 520 530 540 550 560
460 470 480 490 500 510
pF1KA0 WRTHIRVHKKNMPRTKSHPGCGDTVGLIDEQNEASKTNGLGAAEAFPSGCTATAGREGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 WRTHIRVHKKNMPRTKSHPGCGDTVGLIDEQNEASKTNGLGAAEAFPSGCTATAGREGSS
570 580 590 600 610 620
520 530 540 550 560 570
pF1KA0 PEGSTRRTIEGQSPEPVFGDADVDVSAVQAKLGALELNQRDAAAETELRVHPPCQRHCPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PEGSTRRTIEGQSPEPVFGDADVDVSAVQAKLGALELNQRDAAAETELRVHPPCQRHCPE
630 640 650 660 670 680
580 590 600 610 620 630
pF1KA0 PPSAPEENKATSKAPQGSNSKTPIFSPFPSVKPLRKSATARNLGLYGPTERTPTVHFPQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PPSAPEENKATSKAPQGSNSKTPIFSPFPSVKPLRKSATARNLGLYGPTERTPTVHFPQM
690 700 710 720 730 740
640
pF1KA0 SRSFSKPGGGNSGTKKR
:::::::::::::::::
NP_056 SRSFSKPGGGNSGTKKR
750 760
>>NP_001317115 (OMIM: 615077) TBC1 domain family member (737 aa)
initn: 2594 init1: 2564 opt: 2564 Z-score: 2111.4 bits: 401.1 E(85289): 7.3e-111
Smith-Waterman score: 4121; 96.3% identity (96.3% similar) in 647 aa overlap (1-647:115-737)
10 20 30
pF1KA0 MRFTFNERSNPDDDSMGIQIVKDLHRTGCS
::::::::::::::::::::::::::::::
NP_001 TGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQIVKDLHRTGCS
90 100 110 120 130 140
40 50 60 70 80 90
pF1KA0 SYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIYLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIYLI
150 160 170 180 190 200
100 110 120 130 140 150
pF1KA0 DKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTNV
210 220 230 240 250 260
160 170 180 190 200 210
pF1KA0 FTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADEFYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADEFYS
270 280 290 300 310 320
220 230 240 250 260 270
pF1KA0 TMGRLTQEMLENDLLQSHELMQTVYSMAPFPFPQLAELREKYTYNITPFPATVKPTSVSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMGRLTQEMLENDLLQSHELMQTVYSMAPFPFPQLAELREKYTYNITPFPATVKPTSVSG
330 340 350 360 370 380
280 290 300 310 320 330
pF1KA0 RHSKARDSDEENDPDDEDAVVNAVGCLGPFSGFLAPELQKYQKQIKEPNEEQSLRSNNIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RHSKARDSDEENDPDDEDAVVNAVGCLGPFSGFLAPELQKYQKQIKEPNEEQSLRSNNIA
390 400 410 420 430 440
340 350 360 370 380 390
pF1KA0 ELSPGAINSCRSEYHAAFNSMMMERMTTDINALKRQYSRIKKKQQQQVHQVYIRADKGPV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELSPGAINSCRSEYHAAFNSMMMERMTTDINALKRQYSRIKKKQQQQVHQVYIRA-----
450 460 470 480 490
400 410 420 430 440 450
pF1KA0 TSILPSQVNSSPVINHLLLGKKMKMTNRAAKNAVIHIPGHTGGKISPVPYEDLKTKLNSP
:::::::::::::::::::::::::::::::::::::::::
NP_001 -------------------GKKMKMTNRAAKNAVIHIPGHTGGKISPVPYEDLKTKLNSP
500 510 520 530 540
460 470 480 490 500 510
pF1KA0 WRTHIRVHKKNMPRTKSHPGCGDTVGLIDEQNEASKTNGLGAAEAFPSGCTATAGREGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WRTHIRVHKKNMPRTKSHPGCGDTVGLIDEQNEASKTNGLGAAEAFPSGCTATAGREGSS
550 560 570 580 590 600
520 530 540 550 560 570
pF1KA0 PEGSTRRTIEGQSPEPVFGDADVDVSAVQAKLGALELNQRDAAAETELRVHPPCQRHCPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEGSTRRTIEGQSPEPVFGDADVDVSAVQAKLGALELNQRDAAAETELRVHPPCQRHCPE
610 620 630 640 650 660
580 590 600 610 620 630
pF1KA0 PPSAPEENKATSKAPQGSNSKTPIFSPFPSVKPLRKSATARNLGLYGPTERTPTVHFPQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPSAPEENKATSKAPQGSNSKTPIFSPFPSVKPLRKSATARNLGLYGPTERTPTVHFPQM
670 680 690 700 710 720
640
pF1KA0 SRSFSKPGGGNSGTKKR
:::::::::::::::::
NP_001 SRSFSKPGGGNSGTKKR
730
>>XP_016874573 (OMIM: 615077) PREDICTED: TBC1 domain fam (667 aa)
initn: 4318 init1: 2559 opt: 2559 Z-score: 2107.9 bits: 400.3 E(85289): 1.1e-110
Smith-Waterman score: 4282; 97.0% identity (97.0% similar) in 667 aa overlap (1-647:1-667)
10 20 30 40 50 60
pF1KA0 MRFTFNERSNPDDDSMGIQIVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRFTFNERSNPDDDSMGIQIVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 CQGFNILAALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CQGFNILAALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 LPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 SEIILRVSLAIWAKLGEQIECCETADEFYSTMGRLTQEMLENDLLQSHELMQTVYSMAPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEIILRVSLAIWAKLGEQIECCETADEFYSTMGRLTQEMLENDLLQSHELMQTVYSMAPF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PFPQLAELREKYTYNITPFPATVKPTSVSGRHSKARDSDEENDPDDEDAVVNAVGCLGPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFPQLAELREKYTYNITPFPATVKPTSVSGRHSKARDSDEENDPDDEDAVVNAVGCLGPF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 SGFLAPELQKYQKQIKEPNEEQSLRSNNIAELSPGAINSCRSEYHAAFNSMMMERMTTDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGFLAPELQKYQKQIKEPNEEQSLRSNNIAELSPGAINSCRSEYHAAFNSMMMERMTTDI
310 320 330 340 350 360
370 380 390 400
pF1KA0 NALKRQYSRIKKKQQQQVHQVYIRA--------------------DKGPVTSILPSQVNS
::::::::::::::::::::::::: :::::::::::::::
XP_016 NALKRQYSRIKKKQQQQVHQVYIRAGSKEEKDCRFFLGPKDQAVDDKGPVTSILPSQVNS
370 380 390 400 410 420
410 420 430 440 450 460
pF1KA0 SPVINHLLLGKKMKMTNRAAKNAVIHIPGHTGGKISPVPYEDLKTKLNSPWRTHIRVHKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPVINHLLLGKKMKMTNRAAKNAVIHIPGHTGGKISPVPYEDLKTKLNSPWRTHIRVHKK
430 440 450 460 470 480
470 480 490 500 510 520
pF1KA0 NMPRTKSHPGCGDTVGLIDEQNEASKTNGLGAAEAFPSGCTATAGREGSSPEGSTRRTIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NMPRTKSHPGCGDTVGLIDEQNEASKTNGLGAAEAFPSGCTATAGREGSSPEGSTRRTIE
490 500 510 520 530 540
530 540 550 560 570 580
pF1KA0 GQSPEPVFGDADVDVSAVQAKLGALELNQRDAAAETELRVHPPCQRHCPEPPSAPEENKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQSPEPVFGDADVDVSAVQAKLGALELNQRDAAAETELRVHPPCQRHCPEPPSAPEENKA
550 560 570 580 590 600
590 600 610 620 630 640
pF1KA0 TSKAPQGSNSKTPIFSPFPSVKPLRKSATARNLGLYGPTERTPTVHFPQMSRSFSKPGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSKAPQGSNSKTPIFSPFPSVKPLRKSATARNLGLYGPTERTPTVHFPQMSRSFSKPGGG
610 620 630 640 650 660
pF1KA0 NSGTKKR
:::::::
XP_016 NSGTKKR
>>XP_011536380 (OMIM: 615077) PREDICTED: TBC1 domain fam (781 aa)
initn: 4318 init1: 2559 opt: 2559 Z-score: 2106.9 bits: 400.4 E(85289): 1.3e-110
Smith-Waterman score: 4282; 97.0% identity (97.0% similar) in 667 aa overlap (1-647:115-781)
10 20 30
pF1KA0 MRFTFNERSNPDDDSMGIQIVKDLHRTGCS
::::::::::::::::::::::::::::::
XP_011 TGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQIVKDLHRTGCS
90 100 110 120 130 140
40 50 60 70 80 90
pF1KA0 SYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIYLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIYLI
150 160 170 180 190 200
100 110 120 130 140 150
pF1KA0 DKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTNV
210 220 230 240 250 260
160 170 180 190 200 210
pF1KA0 FTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADEFYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADEFYS
270 280 290 300 310 320
220 230 240 250 260 270
pF1KA0 TMGRLTQEMLENDLLQSHELMQTVYSMAPFPFPQLAELREKYTYNITPFPATVKPTSVSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TMGRLTQEMLENDLLQSHELMQTVYSMAPFPFPQLAELREKYTYNITPFPATVKPTSVSG
330 340 350 360 370 380
280 290 300 310 320 330
pF1KA0 RHSKARDSDEENDPDDEDAVVNAVGCLGPFSGFLAPELQKYQKQIKEPNEEQSLRSNNIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RHSKARDSDEENDPDDEDAVVNAVGCLGPFSGFLAPELQKYQKQIKEPNEEQSLRSNNIA
390 400 410 420 430 440
340 350 360 370 380
pF1KA0 ELSPGAINSCRSEYHAAFNSMMMERMTTDINALKRQYSRIKKKQQQQVHQVYIRA-----
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELSPGAINSCRSEYHAAFNSMMMERMTTDINALKRQYSRIKKKQQQQVHQVYIRAGSKEE
450 460 470 480 490 500
390 400 410 420 430
pF1KA0 ---------------DKGPVTSILPSQVNSSPVINHLLLGKKMKMTNRAAKNAVIHIPGH
:::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDCRFFLGPKDQAVDDKGPVTSILPSQVNSSPVINHLLLGKKMKMTNRAAKNAVIHIPGH
510 520 530 540 550 560
440 450 460 470 480 490
pF1KA0 TGGKISPVPYEDLKTKLNSPWRTHIRVHKKNMPRTKSHPGCGDTVGLIDEQNEASKTNGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGGKISPVPYEDLKTKLNSPWRTHIRVHKKNMPRTKSHPGCGDTVGLIDEQNEASKTNGL
570 580 590 600 610 620
500 510 520 530 540 550
pF1KA0 GAAEAFPSGCTATAGREGSSPEGSTRRTIEGQSPEPVFGDADVDVSAVQAKLGALELNQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAAEAFPSGCTATAGREGSSPEGSTRRTIEGQSPEPVFGDADVDVSAVQAKLGALELNQR
630 640 650 660 670 680
560 570 580 590 600 610
pF1KA0 DAAAETELRVHPPCQRHCPEPPSAPEENKATSKAPQGSNSKTPIFSPFPSVKPLRKSATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DAAAETELRVHPPCQRHCPEPPSAPEENKATSKAPQGSNSKTPIFSPFPSVKPLRKSATA
690 700 710 720 730 740
620 630 640
pF1KA0 RNLGLYGPTERTPTVHFPQMSRSFSKPGGGNSGTKKR
:::::::::::::::::::::::::::::::::::::
XP_011 RNLGLYGPTERTPTVHFPQMSRSFSKPGGGNSGTKKR
750 760 770 780
>>NP_060891 (OMIM: 609871) TBC1 domain family member 2A (917 aa)
initn: 365 init1: 134 opt: 257 Z-score: 218.7 bits: 51.2 E(85289): 1.9e-05
Smith-Waterman score: 346; 31.0% identity (57.0% similar) in 277 aa overlap (19-287:669-912)
10 20 30 40
pF1KA0 MRFTFNERSNPDDDSMGIQIVKDLHRTGCSSY---CGQEAEQDRVVLK
:: ::.:: .. : . :. :.
NP_060 VHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDK--LR
640 650 660 670 680 690
50 60 70 80 90 100
pF1KA0 RVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLRA
:::::.. : :.:::::.: :::. : :.: .:. :. .. ... ..: .:. :.: :
NP_060 RVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEES-AFWCLVAIVETIMPADYYCNTLTA
700 710 720 730 740 750
110 120 130 140 150 160
pF1KA0 LSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLP
.::. :..::: :::.: :: : .. :. : :..:::..:: :
NP_060 SQVDQRVLQDLLSEKLPRLMAHL------------GQHHVDLSLV-TFNWFLVVFADSLI
760 770 780 790 800
170 180 190 200 210 220
pF1KA0 NQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADEFYSTMGRLTQEMLENDLL
.. .:..::. ..::.. . : . : :.:. . :. . . :
NP_060 SNILLRVWDAFLYEGTKYNEKEILRLQNGL-----------EIYQYL-RFFTKTISN---
810 820 830 840
230 240 250 260 270 280
pF1KA0 QSHELMQTVYS-MAPFPFPQLAELR----EKYTYNITPFPATVKPTSVSGRHSKARDSDE
:..::. ... : :: . :: .:: :. .. . .: . : :. : .:
NP_060 -SRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRELEQ-LKAEYLERRASRRRAVSE
850 860 870 880 890 900
290 300 310 320 330 340
pF1KA0 ENDPDDEDAVVNAVGCLGPFSGFLAPELQKYQKQIKEPNEEQSLRSNNIAELSPGAINSC
.::
NP_060 GCASEDEVEGEA
910
647 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 06:47:46 2016 done: Sat Nov 5 06:47:47 2016
Total Scan time: 11.080 Total Display time: 0.120
Function used was FASTA [36.3.4 Apr, 2011]