FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0985, 694 aa 1>>>pF1KA0985 694 - 694 aa - 694 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.6768+/-0.00119; mu= -15.9591+/- 0.071 mean_var=538.7992+/-108.171, 0's: 0 Z-trim(116.8): 56 B-trim: 0 in 0/53 Lambda= 0.055254 statistics sampled from 17403 (17456) to 17403 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.803), E-opt: 0.2 (0.536), width: 16 Scan time: 4.570 The best scores are: opt bits E(32554) CCDS44979.1 RPH3A gene_id:22895|Hs108|chr12 ( 694) 4813 398.4 1.8e-110 CCDS31904.1 RPH3A gene_id:22895|Hs108|chr12 ( 690) 4763 394.4 2.9e-109 CCDS10666.1 DOC2A gene_id:8448|Hs108|chr16 ( 400) 1402 126.3 8.5e-29 CCDS73934.1 DOC2B gene_id:8447|Hs108|chr17 ( 412) 890 85.5 1.7e-16 CCDS10994.1 RPH3AL gene_id:9501|Hs108|chr17 ( 315) 746 73.9 3.9e-13 >>CCDS44979.1 RPH3A gene_id:22895|Hs108|chr12 (694 aa) initn: 4813 init1: 4813 opt: 4813 Z-score: 2096.7 bits: 398.4 E(32554): 1.8e-110 Smith-Waterman score: 4813; 100.0% identity (100.0% similar) in 694 aa overlap (1-694:1-694) 10 20 30 40 50 60 pF1KA0 MTDTVFSNSSNRWMYPSDRPLQSNDKEQLQAGWSVHPGGQPDRQRKQEELTDEEKEIINR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MTDTVFSNSSNRWMYPSDRPLQSNDKEQLQAGWSVHPGGQPDRQRKQEELTDEEKEIINR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VIARAEKMEEMEQERIGRLVDRLENMRKNVAGDGVNRCILCGEQLGMLGSACVVCEDCKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 VIARAEKMEEMEQERIGRLVDRLENMRKNVAGDGVNRCILCGEQLGMLGSACVVCEDCKK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 NVCTKCGVETNNRLHSVWLCKICIEQREVWKRSGAWFFKGFPKQVLPQPMPIKKTKPQQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 NVCTKCGVETNNRLHSVWLCKICIEQREVWKRSGAWFFKGFPKQVLPQPMPIKKTKPQQP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VSEPAAPEQPAPEPKHPARAPARGDSEDRRGPGQKTGPDPASAPGRGNYGPPVRRASEAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 VSEPAAPEQPAPEPKHPARAPARGDSEDRRGPGQKTGPDPASAPGRGNYGPPVRRASEAR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 MSSSSRDSESWDHSGGAGDSSRSPAGLRRANSVQASRPAPGSVQSPAPPQPGQPGTPGGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MSSSSRDSESWDHSGGAGDSSRSPAGLRRANSVQASRPAPGSVQSPAPPQPGQPGTPGGS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 RPGPGPAGRFPDQKPEVAPSDPGTTAPPREERTGGVGGYPAVGAREDRMSHPSGPYSQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 RPGPGPAGRFPDQKPEVAPSDPGTTAPPREERTGGVGGYPAVGAREDRMSHPSGPYSQAS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 AAAPQPAAARQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 AAAPQPAAARQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 PMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 PMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 SVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 SVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 QVERVGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 QVERVGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 KAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 KAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISA 610 620 630 640 650 660 670 680 690 pF1KA0 KGERLKHWYECLKNKDKKIERWHQLQNENHVSSD :::::::::::::::::::::::::::::::::: CCDS44 KGERLKHWYECLKNKDKKIERWHQLQNENHVSSD 670 680 690 >>CCDS31904.1 RPH3A gene_id:22895|Hs108|chr12 (690 aa) initn: 4621 init1: 4621 opt: 4763 Z-score: 2075.2 bits: 394.4 E(32554): 2.9e-109 Smith-Waterman score: 4763; 99.3% identity (99.4% similar) in 694 aa overlap (1-694:1-690) 10 20 30 40 50 60 pF1KA0 MTDTVFSNSSNRWMYPSDRPLQSNDKEQLQAGWSVHPGGQPDRQRKQEELTDEEKEIINR ::::::::::::::::::::::: .:::::::::::::::::::::::::::::::: CCDS31 MTDTVFSNSSNRWMYPSDRPLQS----KLQAGWSVHPGGQPDRQRKQEELTDEEKEIINR 10 20 30 40 50 70 80 90 100 110 120 pF1KA0 VIARAEKMEEMEQERIGRLVDRLENMRKNVAGDGVNRCILCGEQLGMLGSACVVCEDCKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 VIARAEKMEEMEQERIGRLVDRLENMRKNVAGDGVNRCILCGEQLGMLGSACVVCEDCKK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KA0 NVCTKCGVETNNRLHSVWLCKICIEQREVWKRSGAWFFKGFPKQVLPQPMPIKKTKPQQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 NVCTKCGVETNNRLHSVWLCKICIEQREVWKRSGAWFFKGFPKQVLPQPMPIKKTKPQQP 120 130 140 150 160 170 190 200 210 220 230 240 pF1KA0 VSEPAAPEQPAPEPKHPARAPARGDSEDRRGPGQKTGPDPASAPGRGNYGPPVRRASEAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 VSEPAAPEQPAPEPKHPARAPARGDSEDRRGPGQKTGPDPASAPGRGNYGPPVRRASEAR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KA0 MSSSSRDSESWDHSGGAGDSSRSPAGLRRANSVQASRPAPGSVQSPAPPQPGQPGTPGGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 MSSSSRDSESWDHSGGAGDSSRSPAGLRRANSVQASRPAPGSVQSPAPPQPGQPGTPGGS 240 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 RPGPGPAGRFPDQKPEVAPSDPGTTAPPREERTGGVGGYPAVGAREDRMSHPSGPYSQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 RPGPGPAGRFPDQKPEVAPSDPGTTAPPREERTGGVGGYPAVGAREDRMSHPSGPYSQAS 300 310 320 330 340 350 370 380 390 400 410 420 pF1KA0 AAAPQPAAARQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 AAAPQPAAARQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLK 360 370 380 390 400 410 430 440 450 460 470 480 pF1KA0 PMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 PMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRI 420 430 440 450 460 470 490 500 510 520 530 540 pF1KA0 SVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 SVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEE 480 490 500 510 520 530 550 560 570 580 590 600 pF1KA0 QVERVGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 QVERVGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGK 540 550 560 570 580 590 610 620 630 640 650 660 pF1KA0 KAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 KAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISA 600 610 620 630 640 650 670 680 690 pF1KA0 KGERLKHWYECLKNKDKKIERWHQLQNENHVSSD :::::::::::::::::::::::::::::::::: CCDS31 KGERLKHWYECLKNKDKKIERWHQLQNENHVSSD 660 670 680 690 >>CCDS10666.1 DOC2A gene_id:8448|Hs108|chr16 (400 aa) initn: 1398 init1: 708 opt: 1402 Z-score: 630.4 bits: 126.3 E(32554): 8.5e-29 Smith-Waterman score: 1407; 56.6% identity (75.6% similar) in 389 aa overlap (304-688:23-389) 280 290 300 310 320 330 pF1KA0 QASRPAPGSVQSPAPPQPGQPGTPGGSRPGPGPAGRFPDQKPEVAPSDPGTTAPPREERT ::: : : . : :: : : CCDS10 MRGRRGDRMTINIQEHMAINVCPGPI-RPIRQISDYFPRGPG---P---EGG 10 20 30 40 340 350 360 370 380 390 pF1KA0 GGVGGYPAVGAREDRMSHPSGPYSQASAAAPQPAAARQPPPPEEEEEEANSYDSDEATTL :: :: .: . : ::: ::. : ..:::::.::.: CCDS10 GGGGG--------------EAPAHLVPLALAPPAALLGATTPEDGAE-VDSYDSDDATAL 50 60 70 80 90 400 410 420 430 440 450 pF1KA0 GALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRN :.:::.::::. . .:.:.:..:::::::: :::::::::::::::: :.:::.::: :: CCDS10 GTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRN 100 110 120 130 140 150 460 470 480 490 500 510 pF1KA0 TRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFN : ::.::: :.: ::::.:. .:.:::.::::::..::::::: : :..:::.:.:.:: CCDS10 TLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFN 160 170 180 190 200 210 520 530 540 550 560 pF1KA0 ICLERVIPMKRAGTTGSA-RGMALY--EEEQVER-VGDIEERGKILVSLMYSTQQGGLIV ::::: .:. .. ..: ::.. : : ::.:. : .::::.::.:: ::... ::.: CCDS10 ICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGRILLSLSYSSRRRGLLV 220 230 240 250 260 270 570 580 590 600 610 620 pF1KA0 GIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSD ::.::.::::::.::::::.:: .:.::. ::.:::: .:::::::::::::::.:. : CCDS10 GILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELST 280 290 300 310 320 330 630 640 650 660 670 680 pF1KA0 LAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQNEN :: :.:...:::::::::::.::: .:: .:.:: ::: .::.. : .:::: : .: CCDS10 LATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQQPDAALERWHTLTSEL 340 350 360 370 380 390 690 pF1KA0 HVSSD CCDS10 PPAAGALSSA 400 >>CCDS73934.1 DOC2B gene_id:8447|Hs108|chr17 (412 aa) initn: 1582 init1: 824 opt: 890 Z-score: 409.7 bits: 85.5 E(32554): 1.7e-16 Smith-Waterman score: 1617; 62.0% identity (79.0% similar) in 400 aa overlap (297-688:24-404) 270 280 290 300 310 320 pF1KA0 LRRANSVQASRPAPGSVQSPAPPQPGQPGTPGGSRPGPGPAGRFPDQKPEVAPSDPG--T :: :: . :: . :. : : : . CCDS73 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFP-RFPRGLPPDAGPRA 10 20 30 40 50 330 340 350 360 370 pF1KA0 TAPPREERTGGVGGY----PAVGAREDR--MSHPSGPYSQASAAAPQPAAARQPPPPEEE .::: .:.: :. ::::: ... : :... . .: :. :: : : :. CCDS73 AAPPDAPARPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPED 60 70 80 90 100 110 380 390 400 410 420 430 pF1KA0 EEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLP : .:..:.::. :.::.:.:::::::.:..:.::: ::::::::: :::::::::::::: CCDS73 EPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLP 120 130 140 150 160 170 440 450 460 470 480 490 pF1KA0 GASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETR ::::.::::::::::: :: :::::.:.::::::: :::::::::::::: ::::::::: CCDS73 GASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETR 180 190 200 210 220 230 500 510 520 530 540 550 pF1KA0 FSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGDIEERGKILVSL :::::::. :.:.::::. .:. .. :.. ..::::.::.:: CCDS73 VPLKKLKPNHTKTFSICLEKQLPVDKT-------------EDK-----SLEERGRILISL 240 250 260 270 560 570 580 590 600 610 pF1KA0 MYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFN ::.:. ::.:::.::.:::::::::::::.:: .:.::. ::.:::: .:::::::::: CCDS73 KYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFN 280 290 300 310 320 330 620 630 640 650 660 670 pF1KA0 EEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKK ::: :.:::.:::::::...:::::::::::.::: ::: :::::::::..:::::::. CCDS73 EEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKR 340 350 360 370 380 390 680 690 pF1KA0 IERWHQLQNENHVSSD ::::: : .: CCDS73 IERWHTLTSELPGAVLSD 400 410 >>CCDS10994.1 RPH3AL gene_id:9501|Hs108|chr17 (315 aa) initn: 651 init1: 387 opt: 746 Z-score: 349.2 bits: 73.9 E(32554): 3.9e-13 Smith-Waterman score: 772; 39.2% identity (66.5% similar) in 337 aa overlap (1-324:1-312) 10 20 30 40 50 60 pF1KA0 MTDTVFSNSSNRWMYPSDRPLQSNDKEQLQAGWSVHPGGQPDRQRKQEELTDEEKEIINR :.::.:......:. :.:: : . .::.::::: : ..::....:. : : : . CCDS10 MADTIFGSGNDQWVCPNDRQLAL--RAKLQTGWSVHTY-QTEKQRRKQHLSPAEVEAILQ 10 20 30 40 50 70 80 90 100 110 120 pF1KA0 VIARAEKMEEMEQERIGRLVDRLENMRKNVAGDGVNRCILCGEQLGMLGSACVVCEDCKK :: :::... .::.::::::.:::.::.:: :.:...:.:::: ::.:::. : :.::.: CCDS10 VIQRAERLDVLEQQRIGRLVERLETMRRNVMGNGLSQCLLCGEVLGFLGSSSVFCKDCRK 60 70 80 90 100 110 130 140 150 160 170 pF1KA0 NVCTKCGVETN-NRLHSVWLCKICIEQREVWKRSGAWFFKGFPKQVLPQPMPIKKTKPQ- .::::::.:.. .. . .:::::: :::::::::::::.::.:: .:: : . :. CCDS10 KVCTKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYKGLPKYILPLKTPGRADDPHF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KA0 QPVSEPAAPEQPAPEPKHPARAPARGDSEDRRGPGQKTGPDPASAPGRGNYGPPVRRASE .:. :. : . :. .. .: . . :: .. : : . .. : CCDS10 RPL--PTEPAEREPRSSETSRIYTWA-----RGRVVSSDSDSDSDLSSSSL--------E 180 190 200 210 220 240 250 260 270 280 pF1KA0 ARMSSSS-RDSES---WDHSGGAGDSSR-----SPAGLRRANSVQAS-RPAPGSVQSPAP :. :.. :: .. : .:::. .. : :. : .: :: . . ::.. :. CCDS10 DRLPSTGVRDRKGDKPWKESGGSVEAPRMGFTHPPGHLSGCQSSLASGETGTGSADPPGG 230 240 250 260 270 280 290 300 310 320 330 340 pF1KA0 PQPGQPG-TPGGSRPGPGPAGRFPDQKPEVAPSDPGTTAPPREERTGGVGGYPAVGARED :.:: .: . :: .::. ..::. :.. CCDS10 PRPGLTRRAPVKDTPGRAPAA-------DAAPAGPSSCLG 290 300 310 350 360 370 380 390 400 pF1KA0 RMSHPSGPYSQASAAAPQPAAARQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNS 694 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 20:11:58 2016 done: Wed Nov 2 20:11:58 2016 Total Scan time: 4.570 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]