FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1012, 1435 aa 1>>>pF1KA1012 1435 - 1435 aa - 1435 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8451+/-0.000468; mu= 20.0977+/- 0.029 mean_var=71.9468+/-14.913, 0's: 0 Z-trim(109.8): 27 B-trim: 685 in 1/52 Lambda= 0.151206 statistics sampled from 17994 (18011) to 17994 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.561), E-opt: 0.2 (0.211), width: 16 Scan time: 10.830 The best scores are: opt bits E(85289) NP_055754 (OMIM: 614136) trafficking protein parti (1435) 9471 2076.4 0 XP_005258290 (OMIM: 614136) PREDICTED: trafficking (1436) 9451 2072.1 0 XP_016881104 (OMIM: 614136) PREDICTED: trafficking (1410) 9122 2000.3 0 XP_016881105 (OMIM: 614136) PREDICTED: trafficking (1405) 8772 1924.0 0 XP_005258291 (OMIM: 614136) PREDICTED: trafficking (1406) 8760 1921.3 0 XP_006722483 (OMIM: 614136) PREDICTED: trafficking (1338) 8758 1920.9 0 XP_016881106 (OMIM: 614136) PREDICTED: trafficking (1293) 8444 1852.4 0 XP_011524186 (OMIM: 614136) PREDICTED: trafficking (1294) 8432 1849.8 0 XP_005258292 (OMIM: 614136) PREDICTED: trafficking (1161) 7554 1658.2 0 >>NP_055754 (OMIM: 614136) trafficking protein particle (1435 aa) initn: 9471 init1: 9471 opt: 9471 Z-score: 11154.1 bits: 2076.4 E(85289): 0 Smith-Waterman score: 9471; 99.9% identity (100.0% similar) in 1435 aa overlap (1-1435:1-1435) 10 20 30 40 50 60 pF1KA1 MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 QLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 PWFESYRETFLQSMPASDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PWFESYRETFLQSMPASDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 IPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVKDGLPNNFRAHPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 IPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVKDGLPNNFRAHPL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 QLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 LPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 LQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRPY 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 PAHYMDTAIQTYRDICKNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PAHYMDTAIQTYRDICKNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSAL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 LLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLAE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 DHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 PLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSV 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 VNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWKF 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 HPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 HPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVV 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 YNLGTIQGSMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 YNLGTIQGSMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 RRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFTF 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 GGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLP 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 DTVLLPGASVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DTVLLPGASVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLN 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA1 VRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVNL 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA1 SENKDAKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFY :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SENKDTKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFY 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA1 RSLSSELKKPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RSLSSELKKPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQ 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA1 HHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPESF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 HHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPESF 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA1 NHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 NHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQL 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 pF1KA1 KSQEIHSLQLKACFVHTGVYNLGTPRVFAKLSDQVTVFETSQQNSMPALIIISNV ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KSQEIHSLQLKACFVHTGVYNLGTPRVFAKLSDQVTVFETSQQNSMPALIIISNV 1390 1400 1410 1420 1430 >>XP_005258290 (OMIM: 614136) PREDICTED: trafficking pro (1436 aa) initn: 9449 init1: 7554 opt: 9451 Z-score: 11130.6 bits: 2072.1 E(85289): 0 Smith-Waterman score: 9451; 99.8% identity (99.9% similar) in 1436 aa overlap (1-1435:1-1436) 10 20 30 40 50 60 pF1KA1 MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 QLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 PWFESYRETFLQSMPASDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS :::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: XP_005 PWFESYRETFLQSMPALDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQ 190 200 210 220 230 240 250 260 270 280 290 pF1KA1 IPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVK-DGLPNNFRAHP :::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_005 IPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVKVDGLPNNFRAHP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA1 LQLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRG 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA1 LLPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAP 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA1 ELQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA1 YPAHYMDTAIQTYRDICKNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YPAHYMDTAIQTYRDICKNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSA 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA1 LLLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLA 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA1 EDHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EDHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPD 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA1 GPLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GPLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVS 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA1 VVNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VVNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWK 730 740 750 760 770 780 780 790 800 810 820 830 pF1KA1 FHPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FHPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGV 790 800 810 820 830 840 840 850 860 870 880 890 pF1KA1 VYNLGTIQGSMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VYNLGTIQGSMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGP 850 860 870 880 890 900 900 910 920 930 940 950 pF1KA1 DRRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DRRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFT 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KA1 FGGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FGGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPL 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA1 PDTVLLPGASVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PDTVLLPGASVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSL 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KA1 NVRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NVRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVN 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KA1 LSENKDAKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFF ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSENKDTKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFF 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KA1 YRSLSSELKKPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YRSLSSELKKPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEG 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KA1 QHHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QHHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPES 1270 1280 1290 1300 1310 1320 1320 1330 1340 1350 1360 1370 pF1KA1 FNHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FNHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQ 1330 1340 1350 1360 1370 1380 1380 1390 1400 1410 1420 1430 pF1KA1 LKSQEIHSLQLKACFVHTGVYNLGTPRVFAKLSDQVTVFETSQQNSMPALIIISNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKSQEIHSLQLKACFVHTGVYNLGTPRVFAKLSDQVTVFETSQQNSMPALIIISNV 1390 1400 1410 1420 1430 >>XP_016881104 (OMIM: 614136) PREDICTED: trafficking pro (1410 aa) initn: 9122 init1: 9122 opt: 9122 Z-score: 10742.8 bits: 2000.3 E(85289): 0 Smith-Waterman score: 9122; 99.9% identity (99.9% similar) in 1383 aa overlap (53-1435:28-1410) 30 40 50 60 70 80 pF1KA1 LCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNNQLHVIKNLKIAVSNIVTQPPQP :::::::::::::::::::::::::::::: XP_016 MIMVHCSLDLLGSSDHSTLASWVAGITVHMRDPNNQLHVIKNLKIAVSNIVTQPPQP 10 20 30 40 50 90 100 110 120 130 140 pF1KA1 GAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATTPWFESYRETFLQSMPASDHEFL :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: XP_016 GAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATTPWFESYRETFLQSMPALDHEFL 60 70 80 90 100 110 150 160 170 180 190 200 pF1KA1 NHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYSYPKWFIPNTLKYYVLLHDVSAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYSYPKWFIPNTLKYYVLLHDVSAG 120 130 140 150 160 170 210 220 230 240 250 260 pF1KA1 DEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQIPDPWSQYLQKNSIQNQESYED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQIPDPWSQYLQKNSIQNQESYED 180 190 200 210 220 230 270 280 290 300 310 320 pF1KA1 GPCTITSNKNSDNNLLSLDGLDNEVKDGLPNNFRAHPLQLEQSSDPSNSIDGPDHLRSAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPCTITSNKNSDNNLLSLDGLDNEVKDGLPNNFRAHPLQLEQSSDPSNSIDGPDHLRSAS 240 250 260 270 280 290 330 340 350 360 370 380 pF1KA1 SLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGLLPHIEKTIRQLNDQLISRKGLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGLLPHIEKTIRQLNDQLISRKGLS 300 310 320 330 340 350 390 400 410 420 430 440 pF1KA1 RSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPELQIRKMADLCFLVQHYDLAYSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPELQIRKMADLCFLVQHYDLAYSC 360 370 380 390 400 410 450 460 470 480 490 500 pF1KA1 YHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRPYPAHYMDTAIQTYRDICKNMVLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRPYPAHYMDTAIQTYRDICKNMVLA 420 430 440 450 460 470 510 520 530 540 550 560 pF1KA1 ERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSALLLEQAAHCFINMKSPMVRKYAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSALLLEQAAHCFINMKSPMVRKYAF 480 490 500 510 520 530 570 580 590 600 610 620 pF1KA1 HMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLAEDHINFTIGRQSYTLRQLDNAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLAEDHINFTIGRQSYTLRQLDNAVS 540 550 560 570 580 590 630 640 650 660 670 680 pF1KA1 AFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDGPLPQLPLPYINSSATRVFFGHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDGPLPQLPLPYINSSATRVFFGHD 600 610 620 630 640 650 690 700 710 720 730 740 pF1KA1 RRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSVVNKGVIPSNFHPTQYCLNSYSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSVVNKGVIPSNFHPTQYCLNSYSD 660 670 680 690 700 710 750 760 770 780 790 800 pF1KA1 NSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWKFHPKDFSGKDNEEVKQLVTSEPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWKFHPKDFSGKDNEEVKQLVTSEPE 720 730 740 750 760 770 810 820 830 840 850 860 pF1KA1 MIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVVYNLGTIQGSMTVDGIGALPGCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVVYNLGTIQGSMTVDGIGALPGCH 780 790 800 810 820 830 870 880 890 900 910 920 pF1KA1 TGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPDRRLDPIITEEMPLLEVFFIHFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPDRRLDPIITEEMPLLEVFFIHFP 840 850 860 870 880 890 930 940 950 960 970 980 pF1KA1 TGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFTFGGNTAVLTPLSPSASENCSAYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFTFGGNTAVLTPLSPSASENCSAYK 900 910 920 930 940 950 990 1000 1010 1020 1030 1040 pF1KA1 TVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLPDTVLLPGASVQLPMWLRGPDEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLPDTVLLPGASVQLPMWLRGPDEE 960 970 980 990 1000 1010 1050 1060 1070 1080 1090 1100 pF1KA1 GVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLNVRATVCRSNSLENEEGRGGNML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLNVRATVCRSNSLENEEGRGGNML 1020 1030 1040 1050 1060 1070 1110 1120 1130 1140 1150 1160 pF1KA1 VFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVNLSENKDAKLASREKGKFCFKAIR :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: XP_016 VFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVNLSENKDTKLASREKGKFCFKAIR 1080 1090 1100 1110 1120 1130 1170 1180 1190 1200 1210 1220 pF1KA1 CEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFYRSLSSELKKPQAHLPVHTEKQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFYRSLSSELKKPQAHLPVHTEKQS 1140 1150 1160 1170 1180 1190 1230 1240 1250 1260 1270 1280 pF1KA1 TEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQHHVILRTIGKEAFSYPQKQEPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQHHVILRTIGKEAFSYPQKQEPP 1200 1210 1220 1230 1240 1250 1290 1300 1310 1320 1330 1340 pF1KA1 EMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPESFNHPFHQKSLCLVPVTLLLSNCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPESFNHPFHQKSLCLVPVTLLLSNCS 1260 1270 1280 1290 1300 1310 1350 1360 1370 1380 1390 1400 pF1KA1 KADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQLKSQEIHSLQLKACFVHTGVYNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQLKSQEIHSLQLKACFVHTGVYNL 1320 1330 1340 1350 1360 1370 1410 1420 1430 pF1KA1 GTPRVFAKLSDQVTVFETSQQNSMPALIIISNV ::::::::::::::::::::::::::::::::: XP_016 GTPRVFAKLSDQVTVFETSQQNSMPALIIISNV 1380 1390 1400 1410 >>XP_016881105 (OMIM: 614136) PREDICTED: trafficking pro (1405 aa) initn: 8772 init1: 8772 opt: 8772 Z-score: 10330.2 bits: 1924.0 E(85289): 0 Smith-Waterman score: 9202; 97.8% identity (97.8% similar) in 1435 aa overlap (1-1435:1-1405) 10 20 30 40 50 60 pF1KA1 MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 QLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 PWFESYRETFLQSMPASDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS :::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: XP_016 PWFESYRETFLQSMPALDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 IPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVKDGLPNNFRAHPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVKDGLPNNFRAHPL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 QLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 LPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 LQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRPY 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 PAHYMDTAIQTYRDICKNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAHYMDTAIQTYRDICKNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSAL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 LLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLAE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 DHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 PLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSV 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 VNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWKF 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 HPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVV 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 YNLGTIQGSMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YNLGTIQGSMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 RRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFTF 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 GGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLP 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 DTVLLPGASVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTVLLPGASVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLN 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA1 VRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVNL 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA1 SENKDAKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFY :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SENKDTKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFY 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA1 RSLSSELKKPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSLSSELKKPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQ 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA1 HHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPESF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPESF 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA1 NHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQL :::::::: :::::::::::::::::::::: XP_016 NHPFHQKS------------------------------PEALEIHGSFTWLGQTQYKLQL 1330 1340 1350 1390 1400 1410 1420 1430 pF1KA1 KSQEIHSLQLKACFVHTGVYNLGTPRVFAKLSDQVTVFETSQQNSMPALIIISNV ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSQEIHSLQLKACFVHTGVYNLGTPRVFAKLSDQVTVFETSQQNSMPALIIISNV 1360 1370 1380 1390 1400 >>XP_005258291 (OMIM: 614136) PREDICTED: trafficking pro (1406 aa) initn: 8758 init1: 6863 opt: 8760 Z-score: 10316.1 bits: 1921.3 E(85289): 0 Smith-Waterman score: 9190; 97.7% identity (97.8% similar) in 1436 aa overlap (1-1435:1-1406) 10 20 30 40 50 60 pF1KA1 MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 QLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 PWFESYRETFLQSMPASDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS :::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: XP_005 PWFESYRETFLQSMPALDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQ 190 200 210 220 230 240 250 260 270 280 290 pF1KA1 IPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVK-DGLPNNFRAHP :::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_005 IPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVKVDGLPNNFRAHP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA1 LQLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRG 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA1 LLPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAP 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA1 ELQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA1 YPAHYMDTAIQTYRDICKNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YPAHYMDTAIQTYRDICKNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSA 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA1 LLLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLA 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA1 EDHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EDHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPD 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA1 GPLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GPLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVS 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA1 VVNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VVNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWK 730 740 750 760 770 780 780 790 800 810 820 830 pF1KA1 FHPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FHPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGV 790 800 810 820 830 840 840 850 860 870 880 890 pF1KA1 VYNLGTIQGSMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VYNLGTIQGSMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGP 850 860 870 880 890 900 900 910 920 930 940 950 pF1KA1 DRRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DRRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFT 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KA1 FGGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FGGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPL 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA1 PDTVLLPGASVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PDTVLLPGASVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSL 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KA1 NVRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NVRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVN 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KA1 LSENKDAKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFF ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSENKDTKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFF 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KA1 YRSLSSELKKPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YRSLSSELKKPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEG 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KA1 QHHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QHHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPES 1270 1280 1290 1300 1310 1320 1320 1330 1340 1350 1360 1370 pF1KA1 FNHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQ ::::::::: ::::::::::::::::::::: XP_005 FNHPFHQKS------------------------------PEALEIHGSFTWLGQTQYKLQ 1330 1340 1350 1380 1390 1400 1410 1420 1430 pF1KA1 LKSQEIHSLQLKACFVHTGVYNLGTPRVFAKLSDQVTVFETSQQNSMPALIIISNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKSQEIHSLQLKACFVHTGVYNLGTPRVFAKLSDQVTVFETSQQNSMPALIIISNV 1360 1370 1380 1390 1400 >>XP_006722483 (OMIM: 614136) PREDICTED: trafficking pro (1338 aa) initn: 8753 init1: 6858 opt: 8758 Z-score: 10314.0 bits: 1920.9 E(85289): 0 Smith-Waterman score: 8758; 99.5% identity (99.7% similar) in 1332 aa overlap (1-1331:1-1331) 10 20 30 40 50 60 pF1KA1 MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 QLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 PWFESYRETFLQSMPASDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS :::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: XP_006 PWFESYRETFLQSMPALDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQ 190 200 210 220 230 240 250 260 270 280 290 pF1KA1 IPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVK-DGLPNNFRAHP :::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_006 IPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVKVDGLPNNFRAHP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA1 LQLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LQLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRG 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA1 LLPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LLPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAP 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA1 ELQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ELQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA1 YPAHYMDTAIQTYRDICKNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YPAHYMDTAIQTYRDICKNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSA 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA1 LLLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LLLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLA 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA1 EDHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EDHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPD 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA1 GPLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GPLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVS 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA1 VVNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VVNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWK 730 740 750 760 770 780 780 790 800 810 820 830 pF1KA1 FHPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FHPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGV 790 800 810 820 830 840 840 850 860 870 880 890 pF1KA1 VYNLGTIQGSMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VYNLGTIQGSMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGP 850 860 870 880 890 900 900 910 920 930 940 950 pF1KA1 DRRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DRRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFT 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KA1 FGGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FGGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPL 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA1 PDTVLLPGASVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PDTVLLPGASVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSL 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KA1 NVRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NVRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVN 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KA1 LSENKDAKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFF ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LSENKDTKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFF 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KA1 YRSLSSELKKPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YRSLSSELKKPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEG 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KA1 QHHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QHHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPES 1270 1280 1290 1300 1310 1320 1320 1330 1340 1350 1360 1370 pF1KA1 FNHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQ :::::::: :. XP_006 FNHPFHQKR-CMQGSPGEM 1330 >>XP_016881106 (OMIM: 614136) PREDICTED: trafficking pro (1293 aa) initn: 8444 init1: 8444 opt: 8444 Z-score: 9944.1 bits: 1852.4 E(85289): 0 Smith-Waterman score: 8444; 99.8% identity (99.9% similar) in 1279 aa overlap (1-1279:1-1279) 10 20 30 40 50 60 pF1KA1 MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 QLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 PWFESYRETFLQSMPASDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS :::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: XP_016 PWFESYRETFLQSMPALDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 IPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVKDGLPNNFRAHPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVKDGLPNNFRAHPL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 QLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 LPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 LQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRPY 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 PAHYMDTAIQTYRDICKNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAHYMDTAIQTYRDICKNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSAL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 LLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLAE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 DHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 PLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSV 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 VNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWKF 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 HPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVV 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 YNLGTIQGSMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YNLGTIQGSMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 RRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFTF 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 GGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLP 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 DTVLLPGASVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTVLLPGASVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLN 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA1 VRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVNL 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA1 SENKDAKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFY :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SENKDTKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFY 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA1 RSLSSELKKPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSLSSELKKPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQ 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA1 HHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPESF ::::::::::::::::::: XP_016 HHVILRTIGKEAFSYPQKQPLFSTSHSFTFQLF 1270 1280 1290 >>XP_011524186 (OMIM: 614136) PREDICTED: trafficking pro (1294 aa) initn: 8430 init1: 6535 opt: 8432 Z-score: 9929.9 bits: 1849.8 E(85289): 0 Smith-Waterman score: 8432; 99.8% identity (99.8% similar) in 1280 aa overlap (1-1279:1-1280) 10 20 30 40 50 60 pF1KA1 MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 QLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 PWFESYRETFLQSMPASDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS :::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: XP_011 PWFESYRETFLQSMPALDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQ 190 200 210 220 230 240 250 260 270 280 290 pF1KA1 IPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVK-DGLPNNFRAHP :::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_011 IPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVKVDGLPNNFRAHP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA1 LQLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRG 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA1 LLPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAP 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA1 ELQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA1 YPAHYMDTAIQTYRDICKNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YPAHYMDTAIQTYRDICKNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSA 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA1 LLLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLA 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA1 EDHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EDHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPD 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA1 GPLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVS 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA1 VVNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWK 730 740 750 760 770 780 780 790 800 810 820 830 pF1KA1 FHPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FHPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGV 790 800 810 820 830 840 840 850 860 870 880 890 pF1KA1 VYNLGTIQGSMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VYNLGTIQGSMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGP 850 860 870 880 890 900 900 910 920 930 940 950 pF1KA1 DRRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DRRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFT 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KA1 FGGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FGGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPL 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA1 PDTVLLPGASVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDTVLLPGASVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSL 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KA1 NVRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NVRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVN 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KA1 LSENKDAKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFF ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSENKDTKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFF 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KA1 YRSLSSELKKPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YRSLSSELKKPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEG 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KA1 QHHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPES :::::::::::::::::::: XP_011 QHHVILRTIGKEAFSYPQKQPLFSTSHSFTFQLF 1270 1280 1290 >>XP_005258292 (OMIM: 614136) PREDICTED: trafficking pro (1161 aa) initn: 7554 init1: 7554 opt: 7554 Z-score: 8895.6 bits: 1658.2 E(85289): 0 Smith-Waterman score: 7554; 99.9% identity (100.0% similar) in 1147 aa overlap (289-1435:15-1161) 260 270 280 290 300 310 pF1KA1 SYEDGPCTITSNKNSDNNLLSLDGLDNEVKDGLPNNFRAHPLQLEQSSDPSNSIDGPDHL :::::::::::::::::::::::::::::: XP_005 MGEIFHNTERYWAVDGLPNNFRAHPLQLEQSSDPSNSIDGPDHL 10 20 30 40 320 330 340 350 360 370 pF1KA1 RSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGLLPHIEKTIRQLNDQLISR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGLLPHIEKTIRQLNDQLISR 50 60 70 80 90 100 380 390 400 410 420 430 pF1KA1 KGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPELQIRKMADLCFLVQHYDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPELQIRKMADLCFLVQHYDL 110 120 130 140 150 160 440 450 460 470 480 490 pF1KA1 AYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRPYPAHYMDTAIQTYRDICKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRPYPAHYMDTAIQTYRDICKN 170 180 190 200 210 220 500 510 520 530 540 550 pF1KA1 MVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSALLLEQAAHCFINMKSPMVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSALLLEQAAHCFINMKSPMVR 230 240 250 260 270 280 560 570 580 590 600 610 pF1KA1 KYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLAEDHINFTIGRQSYTLRQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLAEDHINFTIGRQSYTLRQLD 290 300 310 320 330 340 620 630 640 650 660 670 pF1KA1 NAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDGPLPQLPLPYINSSATRVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDGPLPQLPLPYINSSATRVF 350 360 370 380 390 400 680 690 700 710 720 730 pF1KA1 FGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSVVNKGVIPSNFHPTQYCLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSVVNKGVIPSNFHPTQYCLN 410 420 430 440 450 460 740 750 760 770 780 790 pF1KA1 SYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWKFHPKDFSGKDNEEVKQLVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWKFHPKDFSGKDNEEVKQLVT 470 480 490 500 510 520 800 810 820 830 840 850 pF1KA1 SEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVVYNLGTIQGSMTVDGIGAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVVYNLGTIQGSMTVDGIGAL 530 540 550 560 570 580 860 870 880 890 900 910 pF1KA1 PGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPDRRLDPIITEEMPLLEVFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPDRRLDPIITEEMPLLEVFF 590 600 610 620 630 640 920 930 940 950 960 970 pF1KA1 IHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFTFGGNTAVLTPLSPSASENC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFTFGGNTAVLTPLSPSASENC 650 660 670 680 690 700 980 990 1000 1010 1020 1030 pF1KA1 SAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLPDTVLLPGASVQLPMWLRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLPDTVLLPGASVQLPMWLRG 710 720 730 740 750 760 1040 1050 1060 1070 1080 1090 pF1KA1 PDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLNVRATVCRSNSLENEEGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLNVRATVCRSNSLENEEGRG 770 780 790 800 810 820 1100 1110 1120 1130 1140 1150 pF1KA1 GNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVNLSENKDAKLASREKGKFCF :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: XP_005 GNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVNLSENKDTKLASREKGKFCF 830 840 850 860 870 880 1160 1170 1180 1190 1200 1210 pF1KA1 KAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFYRSLSSELKKPQAHLPVHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFYRSLSSELKKPQAHLPVHT 890 900 910 920 930 940 1220 1230 1240 1250 1260 1270 pF1KA1 EKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQHHVILRTIGKEAFSYPQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQHHVILRTIGKEAFSYPQK 950 960 970 980 990 1000 1280 1290 1300 1310 1320 1330 pF1KA1 QEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPESFNHPFHQKSLCLVPVTLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPESFNHPFHQKSLCLVPVTLLL 1010 1020 1030 1040 1050 1060 1340 1350 1360 1370 1380 1390 pF1KA1 SNCSKADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQLKSQEIHSLQLKACFVHTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SNCSKADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQLKSQEIHSLQLKACFVHTG 1070 1080 1090 1100 1110 1120 1400 1410 1420 1430 pF1KA1 VYNLGTPRVFAKLSDQVTVFETSQQNSMPALIIISNV ::::::::::::::::::::::::::::::::::::: XP_005 VYNLGTPRVFAKLSDQVTVFETSQQNSMPALIIISNV 1130 1140 1150 1160 1435 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 20:15:38 2016 done: Wed Nov 2 20:15:40 2016 Total Scan time: 10.830 Total Display time: 0.590 Function used was FASTA [36.3.4 Apr, 2011]