FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1017, 1015 aa 1>>>pF1KA1017 1015 - 1015 aa - 1015 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5345+/-0.000933; mu= 15.5336+/- 0.056 mean_var=91.4550+/-18.422, 0's: 0 Z-trim(107.4): 21 B-trim: 177 in 1/49 Lambda= 0.134113 statistics sampled from 9557 (9572) to 9557 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.662), E-opt: 0.2 (0.294), width: 16 Scan time: 3.680 The best scores are: opt bits E(32554) CCDS7837.1 HPS5 gene_id:11234|Hs108|chr11 (1015) 6767 1320.1 0 CCDS7836.1 HPS5 gene_id:11234|Hs108|chr11 (1129) 6767 1320.1 0 CCDS58337.1 TECPR2 gene_id:9895|Hs108|chr14 (1267) 318 72.4 6.8e-12 CCDS32162.1 TECPR2 gene_id:9895|Hs108|chr14 (1411) 318 72.4 7.5e-12 >>CCDS7837.1 HPS5 gene_id:11234|Hs108|chr11 (1015 aa) initn: 6767 init1: 6767 opt: 6767 Z-score: 7072.1 bits: 1320.1 E(32554): 0 Smith-Waterman score: 6767; 99.9% identity (100.0% similar) in 1015 aa overlap (1-1015:1-1015) 10 20 30 40 50 60 pF1KA1 MYVSSEHKGRRVTALCWDTAILRVFVGDHAGKVSAIKLNTSKQAKAAAAFVMFPVQTITT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 MYVSSEHKGRRVTALCWDTAILRVFVGDHAGKVSAIKLNTSKQAKAAAAFVMFPVQTITT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 VDSCVVQLDYLDGRLLISSLTRSFLCDTEREKFWKIGNKERDGEYGACFFPGRCSGGQQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 VDSCVVQLDYLDGRLLISSLTRSFLCDTEREKFWKIGNKERDGEYGACFFPGRCSGGQQP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 LIYCARPGSRMWEVNFDGEVISTHQFKKLLSLPPLPVITLRSEPQYDHTAGSSQSLSFPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 LIYCARPGSRMWEVNFDGEVISTHQFKKLLSLPPLPVITLRSEPQYDHTAGSSQSLSFPK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 LLHLSEHCVLTWTERGIYIFIPQNVQVLLWSEVKDIQDVAVCRNELFCLHLNGKVSHLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 LLHLSEHCVLTWTERGIYIFIPQNVQVLLWSEVKDIQDVAVCRNELFCLHLNGKVSHLSL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 ISVERCVERLLRRGLWNLAARTCCLFQNSVIASRARKTLTADKLEHLKSQLDHGTYNDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 ISVERCVERLLRRGLWNLAARTCCLFQNSVIASRARKTLTADKLEHLKSQLDHGTYNDLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 SQMEELILKFEPLDSACSSRRSSISSHESFSILDSGIYRIISSRRGSQSDEDSCSLHSQT ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 SQLEELILKFEPLDSACSSRRSSISSHESFSILDSGIYRIISSRRGSQSDEDSCSLHSQT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 LSEDERFKEFTSQQEEDLPDQCCGSHGNEDNVSHAPVMFETDKNETFLPFGIPLPFRSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 LSEDERFKEFTSQQEEDLPDQCCGSHGNEDNVSHAPVMFETDKNETFLPFGIPLPFRSPS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 PLVSLQAVKESVSSFVRKTTEKIGTLHTSPDLKVRPELRGDEQSCEEDVSSDTCPKEEDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 PLVSLQAVKESVSSFVRKTTEKIGTLHTSPDLKVRPELRGDEQSCEEDVSSDTCPKEEDT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 EEEKEVTSPPPEEDRFQELKVATAEAMTKLQDPLVLFESESLRMVLQEWLSHLEKTFAMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 EEEKEVTSPPPEEDRFQELKVATAEAMTKLQDPLVLFESESLRMVLQEWLSHLEKTFAMK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 DFSGVSDTDNSSMKLNQDVLLVNESKKGILDEDNEKEKRDSLGNEESVDKTACECVRSPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 DFSGVSDTDNSSMKLNQDVLLVNESKKGILDEDNEKEKRDSLGNEESVDKTACECVRSPR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 ESLDDLFQICSPCAIASGLRNDLAELTTLCLELNVLNSKIKSTSGHVDHTLQQYSPEILA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 ESLDDLFQICSPCAIASGLRNDLAELTTLCLELNVLNSKIKSTSGHVDHTLQQYSPEILA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 CQFLKKYFFLLNLKRAKESIKLSYSNSPSVWDTFIEGLKEMASSNPVYMEMEKGDLPTRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 CQFLKKYFFLLNLKRAKESIKLSYSNSPSVWDTFIEGLKEMASSNPVYMEMEKGDLPTRL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 KLLDDEVPFDSPLLVVYATRLYEKFGESALRSLIKFFPSILPSDIIQLCHHHPAEFLAYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 KLLDDEVPFDSPLLVVYATRLYEKFGESALRSLIKFFPSILPSDIIQLCHHHPAEFLAYL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 DSLVKSRPEDQRSSFLESLLQPESLRLDWLLLAVSLDAPPSTSTMDDEGYPRPHSHLLSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 DSLVKSRPEDQRSSFLESLLQPESLRLDWLLLAVSLDAPPSTSTMDDEGYPRPHSHLLSW 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 GYSQLILHLIKLPADFITKEKMTDICRSCGFWPGYLILCLELERRREAFTNIVYLNDMSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 GYSQLILHLIKLPADFITKEKMTDICRSCGFWPGYLILCLELERRREAFTNIVYLNDMSL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 MEGDNGWIPETVEEWKLLLHLIQSKSTRPAPQESLNGSLSDGPSPINVENVALLLAKAMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 MEGDNGWIPETVEEWKLLLHLIQSKSTRPAPQESLNGSLSDGPSPINVENVALLLAKAMG 910 920 930 940 950 960 970 980 990 1000 1010 pF1KA1 PDRAWSLLQECGLALELSEKFTRTCDILRIAEKRQRALIQSMLEKCDRFLWSQQA ::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 PDRAWSLLQECGLALELSEKFTRTCDILRIAEKRQRALIQSMLEKCDRFLWSQQA 970 980 990 1000 1010 >>CCDS7836.1 HPS5 gene_id:11234|Hs108|chr11 (1129 aa) initn: 6767 init1: 6767 opt: 6767 Z-score: 7071.3 bits: 1320.1 E(32554): 0 Smith-Waterman score: 6767; 99.9% identity (100.0% similar) in 1015 aa overlap (1-1015:115-1129) 10 20 30 pF1KA1 MYVSSEHKGRRVTALCWDTAILRVFVGDHA :::::::::::::::::::::::::::::: CCDS78 HDDDYVAVATSQGLVVVWELNQERRGKPEQMYVSSEHKGRRVTALCWDTAILRVFVGDHA 90 100 110 120 130 140 40 50 60 70 80 90 pF1KA1 GKVSAIKLNTSKQAKAAAAFVMFPVQTITTVDSCVVQLDYLDGRLLISSLTRSFLCDTER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 GKVSAIKLNTSKQAKAAAAFVMFPVQTITTVDSCVVQLDYLDGRLLISSLTRSFLCDTER 150 160 170 180 190 200 100 110 120 130 140 150 pF1KA1 EKFWKIGNKERDGEYGACFFPGRCSGGQQPLIYCARPGSRMWEVNFDGEVISTHQFKKLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 EKFWKIGNKERDGEYGACFFPGRCSGGQQPLIYCARPGSRMWEVNFDGEVISTHQFKKLL 210 220 230 240 250 260 160 170 180 190 200 210 pF1KA1 SLPPLPVITLRSEPQYDHTAGSSQSLSFPKLLHLSEHCVLTWTERGIYIFIPQNVQVLLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 SLPPLPVITLRSEPQYDHTAGSSQSLSFPKLLHLSEHCVLTWTERGIYIFIPQNVQVLLW 270 280 290 300 310 320 220 230 240 250 260 270 pF1KA1 SEVKDIQDVAVCRNELFCLHLNGKVSHLSLISVERCVERLLRRGLWNLAARTCCLFQNSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 SEVKDIQDVAVCRNELFCLHLNGKVSHLSLISVERCVERLLRRGLWNLAARTCCLFQNSV 330 340 350 360 370 380 280 290 300 310 320 330 pF1KA1 IASRARKTLTADKLEHLKSQLDHGTYNDLISQMEELILKFEPLDSACSSRRSSISSHESF ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: CCDS78 IASRARKTLTADKLEHLKSQLDHGTYNDLISQLEELILKFEPLDSACSSRRSSISSHESF 390 400 410 420 430 440 340 350 360 370 380 390 pF1KA1 SILDSGIYRIISSRRGSQSDEDSCSLHSQTLSEDERFKEFTSQQEEDLPDQCCGSHGNED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 SILDSGIYRIISSRRGSQSDEDSCSLHSQTLSEDERFKEFTSQQEEDLPDQCCGSHGNED 450 460 470 480 490 500 400 410 420 430 440 450 pF1KA1 NVSHAPVMFETDKNETFLPFGIPLPFRSPSPLVSLQAVKESVSSFVRKTTEKIGTLHTSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 NVSHAPVMFETDKNETFLPFGIPLPFRSPSPLVSLQAVKESVSSFVRKTTEKIGTLHTSP 510 520 530 540 550 560 460 470 480 490 500 510 pF1KA1 DLKVRPELRGDEQSCEEDVSSDTCPKEEDTEEEKEVTSPPPEEDRFQELKVATAEAMTKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 DLKVRPELRGDEQSCEEDVSSDTCPKEEDTEEEKEVTSPPPEEDRFQELKVATAEAMTKL 570 580 590 600 610 620 520 530 540 550 560 570 pF1KA1 QDPLVLFESESLRMVLQEWLSHLEKTFAMKDFSGVSDTDNSSMKLNQDVLLVNESKKGIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 QDPLVLFESESLRMVLQEWLSHLEKTFAMKDFSGVSDTDNSSMKLNQDVLLVNESKKGIL 630 640 650 660 670 680 580 590 600 610 620 630 pF1KA1 DEDNEKEKRDSLGNEESVDKTACECVRSPRESLDDLFQICSPCAIASGLRNDLAELTTLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 DEDNEKEKRDSLGNEESVDKTACECVRSPRESLDDLFQICSPCAIASGLRNDLAELTTLC 690 700 710 720 730 740 640 650 660 670 680 690 pF1KA1 LELNVLNSKIKSTSGHVDHTLQQYSPEILACQFLKKYFFLLNLKRAKESIKLSYSNSPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 LELNVLNSKIKSTSGHVDHTLQQYSPEILACQFLKKYFFLLNLKRAKESIKLSYSNSPSV 750 760 770 780 790 800 700 710 720 730 740 750 pF1KA1 WDTFIEGLKEMASSNPVYMEMEKGDLPTRLKLLDDEVPFDSPLLVVYATRLYEKFGESAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 WDTFIEGLKEMASSNPVYMEMEKGDLPTRLKLLDDEVPFDSPLLVVYATRLYEKFGESAL 810 820 830 840 850 860 760 770 780 790 800 810 pF1KA1 RSLIKFFPSILPSDIIQLCHHHPAEFLAYLDSLVKSRPEDQRSSFLESLLQPESLRLDWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 RSLIKFFPSILPSDIIQLCHHHPAEFLAYLDSLVKSRPEDQRSSFLESLLQPESLRLDWL 870 880 890 900 910 920 820 830 840 850 860 870 pF1KA1 LLAVSLDAPPSTSTMDDEGYPRPHSHLLSWGYSQLILHLIKLPADFITKEKMTDICRSCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 LLAVSLDAPPSTSTMDDEGYPRPHSHLLSWGYSQLILHLIKLPADFITKEKMTDICRSCG 930 940 950 960 970 980 880 890 900 910 920 930 pF1KA1 FWPGYLILCLELERRREAFTNIVYLNDMSLMEGDNGWIPETVEEWKLLLHLIQSKSTRPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 FWPGYLILCLELERRREAFTNIVYLNDMSLMEGDNGWIPETVEEWKLLLHLIQSKSTRPA 990 1000 1010 1020 1030 1040 940 950 960 970 980 990 pF1KA1 PQESLNGSLSDGPSPINVENVALLLAKAMGPDRAWSLLQECGLALELSEKFTRTCDILRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 PQESLNGSLSDGPSPINVENVALLLAKAMGPDRAWSLLQECGLALELSEKFTRTCDILRI 1050 1060 1070 1080 1090 1100 1000 1010 pF1KA1 AEKRQRALIQSMLEKCDRFLWSQQA ::::::::::::::::::::::::: CCDS78 AEKRQRALIQSMLEKCDRFLWSQQA 1110 1120 >>CCDS58337.1 TECPR2 gene_id:9895|Hs108|chr14 (1267 aa) initn: 246 init1: 94 opt: 318 Z-score: 327.0 bits: 72.4 E(32554): 6.8e-12 Smith-Waterman score: 324; 30.4% identity (57.7% similar) in 260 aa overlap (3-255:122-366) 10 20 30 pF1KA1 MYVSSEHKGRRVTALCWDTAILRVFVGDHAGK :.. ::. .::: :. ...: :: :: CCDS58 VAAGTASGRVAVFQLVSSLPGRNKQLRRFDVTGIHKNS-ITALAWSPNGMKLFSGDDKGK 100 110 120 130 140 150 40 50 60 70 80 90 pF1KA1 VSAIKLNTSKQAKAAAAFVMFPVQTITTVDSCVVQLDYLDGRLLISSLTRSFLCDTEREK . .:. .. . : . : .::::: . ::.:.: ::.: ::... CCDS58 IVYSSLDLDQG--------LCNSQLVLEEPSSIVQLDYSQKVLLVSTLQRSLLFYTEEKS 160 170 180 190 200 100 110 120 130 140 150 pF1KA1 FWKIGNKERD--GEYGACFFPGRCSGGQQPLIYCARPGSRMWEVNFDGEVISTHQFKKLL .::.. : :..::::.:: :. .. : : .::: :.:... : : .: .: . CCDS58 VRQIGTQPRKSTGKFGACFIPGLCKQSDLTL-YASRPGLRLWKADVHGTVQATFILKDAF 210 220 230 240 250 260 160 170 180 190 200 pF1KA1 SLPPLPVITLRSEPQYDHTAGSSQSLSFPKLLHLS----EHCVLTWTERGIYIFIPQNVQ . : .. .:. . ..: :: .: .: : ::.:.: .::.. : CCDS58 AGGVKP---FELHPRLESPNSGSCSLPERHLGLVSCFFQEGWVLSWNEYSIYLLDTVNQA 270 280 290 300 310 210 220 230 240 250 260 pF1KA1 VLLWSEVK-DIQDVAVCRNELFCLHLNGKVSHLSLISVERCVERLLRRGLWNLAARTCCL .. : . :: .:. .::.: :. . .. ..: : . . .: :: CCDS58 TVAGLEGSGDIVSVSCTENEIFFLKGDRNIIRIS--SRPEGLTSTVRDGLEMSGCSERVH 320 330 340 350 360 370 270 280 290 300 310 320 pF1KA1 FQNSVIASRARKTLTADKLEHLKSQLDHGTYNDLISQMEELILKFEPLDSACSSRRSSIS CCDS58 VQQAEKLPGATVSETRLRGSSMASSVASEPRSRSSSLNSTDSGSGLLPPGLQATPELGKG 380 390 400 410 420 430 >>CCDS32162.1 TECPR2 gene_id:9895|Hs108|chr14 (1411 aa) initn: 246 init1: 94 opt: 318 Z-score: 326.3 bits: 72.4 E(32554): 7.5e-12 Smith-Waterman score: 324; 30.4% identity (57.7% similar) in 260 aa overlap (3-255:122-366) 10 20 30 pF1KA1 MYVSSEHKGRRVTALCWDTAILRVFVGDHAGK :.. ::. .::: :. ...: :: :: CCDS32 VAAGTASGRVAVFQLVSSLPGRNKQLRRFDVTGIHKNS-ITALAWSPNGMKLFSGDDKGK 100 110 120 130 140 150 40 50 60 70 80 90 pF1KA1 VSAIKLNTSKQAKAAAAFVMFPVQTITTVDSCVVQLDYLDGRLLISSLTRSFLCDTEREK . .:. .. . : . : .::::: . ::.:.: ::.: ::... CCDS32 IVYSSLDLDQG--------LCNSQLVLEEPSSIVQLDYSQKVLLVSTLQRSLLFYTEEKS 160 170 180 190 200 100 110 120 130 140 150 pF1KA1 FWKIGNKERD--GEYGACFFPGRCSGGQQPLIYCARPGSRMWEVNFDGEVISTHQFKKLL .::.. : :..::::.:: :. .. : : .::: :.:... : : .: .: . CCDS32 VRQIGTQPRKSTGKFGACFIPGLCKQSDLTL-YASRPGLRLWKADVHGTVQATFILKDAF 210 220 230 240 250 260 160 170 180 190 200 pF1KA1 SLPPLPVITLRSEPQYDHTAGSSQSLSFPKLLHLS----EHCVLTWTERGIYIFIPQNVQ . : .. .:. . ..: :: .: .: : ::.:.: .::.. : CCDS32 AGGVKP---FELHPRLESPNSGSCSLPERHLGLVSCFFQEGWVLSWNEYSIYLLDTVNQA 270 280 290 300 310 210 220 230 240 250 260 pF1KA1 VLLWSEVK-DIQDVAVCRNELFCLHLNGKVSHLSLISVERCVERLLRRGLWNLAARTCCL .. : . :: .:. .::.: :. . .. ..: : . . .: :: CCDS32 TVAGLEGSGDIVSVSCTENEIFFLKGDRNIIRIS--SRPEGLTSTVRDGLEMSGCSERVH 320 330 340 350 360 370 270 280 290 300 310 320 pF1KA1 FQNSVIASRARKTLTADKLEHLKSQLDHGTYNDLISQMEELILKFEPLDSACSSRRSSIS CCDS32 VQQAEKLPGATVSETRLRGSSMASSVASEPRSRSSSLNSTDSGSGLLPPGLQATPELGKG 380 390 400 410 420 430 1015 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 01:17:42 2016 done: Fri Nov 4 01:17:42 2016 Total Scan time: 3.680 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]