FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1042, 953 aa 1>>>pF1KA1042 953 - 953 aa - 953 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.5242+/-0.000425; mu= -3.3642+/- 0.026 mean_var=286.5623+/-58.635, 0's: 0 Z-trim(119.8): 39 B-trim: 555 in 3/55 Lambda= 0.075764 statistics sampled from 34208 (34252) to 34208 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.732), E-opt: 0.2 (0.402), width: 16 Scan time: 16.200 The best scores are: opt bits E(85289) NP_001036111 (OMIM: 608112) trafficking kinesin-bi ( 953) 6206 692.8 2.2e-198 XP_005265015 (OMIM: 608112) PREDICTED: trafficking ( 879) 5547 620.7 1e-176 XP_005265017 (OMIM: 608112) PREDICTED: trafficking ( 712) 4460 501.8 5e-141 XP_005265019 (OMIM: 608112) PREDICTED: trafficking ( 666) 4231 476.8 1.6e-133 XP_006713092 (OMIM: 608112) PREDICTED: trafficking ( 666) 4231 476.8 1.6e-133 XP_011531791 (OMIM: 608112) PREDICTED: trafficking ( 664) 4226 476.2 2.4e-133 NP_001252537 (OMIM: 608112) trafficking kinesin-bi ( 744) 4220 475.6 4.1e-133 XP_016861401 (OMIM: 608112) PREDICTED: trafficking ( 758) 4220 475.6 4.1e-133 XP_016861395 (OMIM: 608112) PREDICTED: trafficking (1022) 4220 475.7 5.2e-133 XP_016861402 (OMIM: 608112) PREDICTED: trafficking ( 691) 4090 461.4 7.2e-129 XP_005265020 (OMIM: 608112) PREDICTED: trafficking ( 645) 4089 461.3 7.4e-129 XP_006713093 (OMIM: 608112) PREDICTED: trafficking ( 645) 4089 461.3 7.4e-129 XP_005265013 (OMIM: 608112) PREDICTED: trafficking ( 932) 4092 461.7 7.9e-129 XP_006713094 (OMIM: 608112) PREDICTED: trafficking ( 643) 4079 460.2 1.6e-128 NP_001252538 (OMIM: 608112) trafficking kinesin-bi ( 670) 3561 403.5 1.8e-111 NP_055780 (OMIM: 608112) trafficking kinesin-bindi ( 686) 3561 403.6 1.8e-111 XP_016861397 (OMIM: 608112) PREDICTED: trafficking ( 925) 3561 403.6 2.3e-111 XP_016861396 (OMIM: 608112) PREDICTED: trafficking ( 941) 3561 403.6 2.4e-111 XP_016861398 (OMIM: 608112) PREDICTED: trafficking ( 895) 3504 397.4 1.7e-109 XP_016861399 (OMIM: 608112) PREDICTED: trafficking ( 858) 3433 389.6 3.6e-107 XP_016861400 (OMIM: 608112) PREDICTED: trafficking ( 828) 3376 383.4 2.6e-105 NP_001252539 (OMIM: 608112) trafficking kinesin-bi ( 556) 3059 348.6 5.1e-95 XP_011509992 (OMIM: 607334) PREDICTED: trafficking ( 914) 1815 212.8 6.5e-54 NP_055864 (OMIM: 607334) trafficking kinesin-bindi ( 914) 1815 212.8 6.5e-54 XP_016860261 (OMIM: 607334) PREDICTED: trafficking ( 703) 1175 142.8 6e-33 NP_817084 (OMIM: 600947) huntingtin-associated pro ( 619) 259 42.6 0.0075 >>NP_001036111 (OMIM: 608112) trafficking kinesin-bindin (953 aa) initn: 6206 init1: 6206 opt: 6206 Z-score: 3682.5 bits: 692.8 E(85289): 2.2e-198 Smith-Waterman score: 6206; 100.0% identity (100.0% similar) in 953 aa overlap (1-953:1-953) 10 20 30 40 50 60 pF1KA1 MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTDLPEVEIISLLEEQLPHYKLRADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTDLPEVEIISLLEEQLPHYKLRADT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 IYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETIT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 YEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 CAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDER 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 SKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 TESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGI 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 LDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSAHHPGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSAHHPGK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 CMSQTNSTFTFTTCRILHPSDELTRVTPSLNSAPTPACGSTSHLKSTPVATPCTPRRLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CMSQTNSTFTFTTCRILHPSDELTRVTPSLNSAPTPACGSTSHLKSTPVATPCTPRRLSL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 AESFTNTRESTTTMSTSLGLVWLLKERGISAAVYDPQSWDRAGRGSLLHSYTPKMAVIPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AESFTNTRESTTTMSTSLGLVWLLKERGISAAVYDPQSWDRAGRGSLLHSYTPKMAVIPS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 TPPNSPMQTPTSSPPSFEFKCTSPPYDNFLASKPASSILREVREKNVRSSESQTDVSVSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPPNSPMQTPTSSPPSFEFKCTSPPYDNFLASKPASSILREVREKNVRSSESQTDVSVSN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 LNLVDKVRRFGVAKVVNSGRAHVPTLTEEQGPLLCGPPGPAPALVPRGLVPEGLPLRCPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNLVDKVRRFGVAKVVNSGRAHVPTLTEEQGPLLCGPPGPAPALVPRGLVPEGLPLRCPT 850 860 870 880 890 900 910 920 930 940 950 pF1KA1 VTSAIGGLQLNSGIRRNRSFPTMVGSSMQMKAPVTLTSGILMGAKLSKQTSLR ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTSAIGGLQLNSGIRRNRSFPTMVGSSMQMKAPVTLTSGILMGAKLSKQTSLR 910 920 930 940 950 >>XP_005265015 (OMIM: 608112) PREDICTED: trafficking kin (879 aa) initn: 5547 init1: 5547 opt: 5547 Z-score: 3293.7 bits: 620.7 E(85289): 1e-176 Smith-Waterman score: 5547; 99.9% identity (100.0% similar) in 858 aa overlap (96-953:22-879) 70 80 90 100 110 120 pF1KA1 HDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLEEKERD .::::::::::::::::::::::::::::: XP_005 MQKFIEADYYELDWYYEECSDVLCAERVGQMTKTYNDIDAVTRLLEEKERD 10 20 30 40 50 130 140 150 160 170 180 pF1KA1 LELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEES 60 70 80 90 100 110 190 200 210 220 230 240 pF1KA1 EPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKE 120 130 140 150 160 170 250 260 270 280 290 300 pF1KA1 QQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVEN 180 190 200 210 220 230 310 320 330 340 350 360 pF1KA1 EELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHS 240 250 260 270 280 290 370 380 390 400 410 420 pF1KA1 LGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTPSPMNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTPSPMNI 300 310 320 330 340 350 430 440 450 460 470 480 pF1KA1 PGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDERSKKPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDERSKKPG 360 370 380 390 400 410 490 500 510 520 530 540 pF1KA1 TPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTPTESIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTPTESIM 420 430 440 450 460 470 550 560 570 580 590 600 pF1KA1 SLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGILDPRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGILDPRP 480 490 500 510 520 530 610 620 630 640 650 660 pF1KA1 GVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSAHHPGKCMSQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSAHHPGKCMSQT 540 550 560 570 580 590 670 680 690 700 710 720 pF1KA1 NSTFTFTTCRILHPSDELTRVTPSLNSAPTPACGSTSHLKSTPVATPCTPRRLSLAESFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSTFTFTTCRILHPSDELTRVTPSLNSAPTPACGSTSHLKSTPVATPCTPRRLSLAESFT 600 610 620 630 640 650 730 740 750 760 770 780 pF1KA1 NTRESTTTMSTSLGLVWLLKERGISAAVYDPQSWDRAGRGSLLHSYTPKMAVIPSTPPNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NTRESTTTMSTSLGLVWLLKERGISAAVYDPQSWDRAGRGSLLHSYTPKMAVIPSTPPNS 660 670 680 690 700 710 790 800 810 820 830 840 pF1KA1 PMQTPTSSPPSFEFKCTSPPYDNFLASKPASSILREVREKNVRSSESQTDVSVSNLNLVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PMQTPTSSPPSFEFKCTSPPYDNFLASKPASSILREVREKNVRSSESQTDVSVSNLNLVD 720 730 740 750 760 770 850 860 870 880 890 900 pF1KA1 KVRRFGVAKVVNSGRAHVPTLTEEQGPLLCGPPGPAPALVPRGLVPEGLPLRCPTVTSAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVRRFGVAKVVNSGRAHVPTLTEEQGPLLCGPPGPAPALVPRGLVPEGLPLRCPTVTSAI 780 790 800 810 820 830 910 920 930 940 950 pF1KA1 GGLQLNSGIRRNRSFPTMVGSSMQMKAPVTLTSGILMGAKLSKQTSLR :::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGLQLNSGIRRNRSFPTMVGSSMQMKAPVTLTSGILMGAKLSKQTSLR 840 850 860 870 >>XP_005265017 (OMIM: 608112) PREDICTED: trafficking kin (712 aa) initn: 4460 init1: 4460 opt: 4460 Z-score: 2652.9 bits: 501.8 E(85289): 5e-141 Smith-Waterman score: 4460; 100.0% identity (100.0% similar) in 688 aa overlap (1-688:1-688) 10 20 30 40 50 60 pF1KA1 MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTDLPEVEIISLLEEQLPHYKLRADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTDLPEVEIISLLEEQLPHYKLRADT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 IYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETIT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 YEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 CAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDER 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 SKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 TESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGI 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 LDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSAHHPGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSAHHPGK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 CMSQTNSTFTFTTCRILHPSDELTRVTPSLNSAPTPACGSTSHLKSTPVATPCTPRRLSL :::::::::::::::::::::::::::: XP_005 CMSQTNSTFTFTTCRILHPSDELTRVTPRSCEEDDEAAICPVELRGDIGQRV 670 680 690 700 710 >>XP_005265019 (OMIM: 608112) PREDICTED: trafficking kin (666 aa) initn: 4220 init1: 4220 opt: 4231 Z-score: 2518.1 bits: 476.8 E(85289): 1.6e-133 Smith-Waterman score: 4231; 99.1% identity (99.4% similar) in 663 aa overlap (1-659:1-663) 10 20 30 40 50 60 pF1KA1 MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTDLPEVEIISLLEEQLPHYKLRADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTDLPEVEIISLLEEQLPHYKLRADT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 IYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETIT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 YEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 CAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDER 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 SKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 TESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGI 550 560 570 580 590 600 610 620 630 640 650 pF1KA1 LDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSA----H ::::::::::::::::::::::::::::::::::::::::::::::::::::::. . XP_005 LDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSGREVQQ 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA1 HPGKCMSQTNSTFTFTTCRILHPSDELTRVTPSLNSAPTPACGSTSHLKSTPVATPCTPR ::: XP_005 HPGSQW >>XP_006713092 (OMIM: 608112) PREDICTED: trafficking kin (666 aa) initn: 4220 init1: 4220 opt: 4231 Z-score: 2518.1 bits: 476.8 E(85289): 1.6e-133 Smith-Waterman score: 4231; 99.1% identity (99.4% similar) in 663 aa overlap (1-659:1-663) 10 20 30 40 50 60 pF1KA1 MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTDLPEVEIISLLEEQLPHYKLRADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTDLPEVEIISLLEEQLPHYKLRADT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 IYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETIT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 YEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 CAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDER 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 SKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 TESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGI 550 560 570 580 590 600 610 620 630 640 650 pF1KA1 LDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSA----H ::::::::::::::::::::::::::::::::::::::::::::::::::::::. . XP_006 LDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSGREVQQ 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA1 HPGKCMSQTNSTFTFTTCRILHPSDELTRVTPSLNSAPTPACGSTSHLKSTPVATPCTPR ::: XP_006 HPGSQW >>XP_011531791 (OMIM: 608112) PREDICTED: trafficking kin (664 aa) initn: 4220 init1: 4220 opt: 4226 Z-score: 2515.1 bits: 476.2 E(85289): 2.4e-133 Smith-Waterman score: 4226; 99.1% identity (99.1% similar) in 663 aa overlap (1-659:1-663) 10 20 30 40 50 60 pF1KA1 MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTDLPEVEIISLLEEQLPHYKLRADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTDLPEVEIISLLEEQLPHYKLRADT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 IYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETIT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 YEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 CAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDER 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 SKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 TESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGI 550 560 570 580 590 600 610 620 630 640 650 pF1KA1 LDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSAH---- :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSELALFL 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA1 HPGKCMSQTNSTFTFTTCRILHPSDELTRVTPSLNSAPTPACGSTSHLKSTPVATPCTPR ::: XP_011 HPGL >>NP_001252537 (OMIM: 608112) trafficking kinesin-bindin (744 aa) initn: 4220 init1: 4220 opt: 4220 Z-score: 2510.9 bits: 475.6 E(85289): 4.1e-133 Smith-Waterman score: 4220; 100.0% identity (100.0% similar) in 654 aa overlap (1-654:1-654) 10 20 30 40 50 60 pF1KA1 MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTDLPEVEIISLLEEQLPHYKLRADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTDLPEVEIISLLEEQLPHYKLRADT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 IYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETIT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 YEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 CAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDER 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 SKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 TESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGI 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 LDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSAHHPGK :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSGERSQA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 CMSQTNSTFTFTTCRILHPSDELTRVTPSLNSAPTPACGSTSHLKSTPVATPCTPRRLSL NP_001 RVTVSGSRSYPSRPQASPEEMQEPPAATEEEEEEEEEEGSGEGTTISPVNLAPFPEAEFW 670 680 690 700 710 720 >>XP_016861401 (OMIM: 608112) PREDICTED: trafficking kin (758 aa) initn: 4220 init1: 4220 opt: 4220 Z-score: 2510.8 bits: 475.6 E(85289): 4.1e-133 Smith-Waterman score: 4358; 93.7% identity (93.7% similar) in 734 aa overlap (1-688:1-734) 10 20 30 40 50 60 pF1KA1 MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTDLPEVEIISLLEEQLPHYKLRADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTDLPEVEIISLLEEQLPHYKLRADT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 IYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETIT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 YEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 CAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDER 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 SKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 TESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGI 550 560 570 580 590 600 610 620 630 640 650 pF1KA1 LDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETS------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSGERSQA 610 620 630 640 650 660 660 670 pF1KA1 ----------------------------------------AHHPGKCMSQTNSTFTFTTC :::::::::::::::::::: XP_016 RVTVSGSRSYPSRPQASPEEMQEPPAATEEEEEEEEEEGSAHHPGKCMSQTNSTFTFTTC 670 680 690 700 710 720 680 690 700 710 720 730 pF1KA1 RILHPSDELTRVTPSLNSAPTPACGSTSHLKSTPVATPCTPRRLSLAESFTNTRESTTTM :::::::::::::: XP_016 RILHPSDELTRVTPRSCEEDDEAAICPVELRGDIGQRV 730 740 750 >>XP_016861395 (OMIM: 608112) PREDICTED: trafficking kin (1022 aa) initn: 4220 init1: 4220 opt: 4220 Z-score: 2508.9 bits: 475.7 E(85289): 5.2e-133 Smith-Waterman score: 6023; 95.3% identity (95.3% similar) in 985 aa overlap (1-939:24-1008) 10 20 30 pF1KA1 MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTD ::::::::::::::::::::::::::::::::::::: XP_016 MLPATEGTGMPAPLLCLWSLCLHMALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTD 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA1 LPEVEIISLLEEQLPHYKLRADTIYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPEVEIISLLEEQLPHYKLRADTIYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA1 CAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHI 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA1 REEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKL 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA1 KDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDA 250 260 270 280 290 300 280 290 300 310 320 330 pF1KA1 ARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECM 310 320 330 340 350 360 340 350 360 370 380 390 pF1KA1 EMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDIT 370 380 390 400 410 420 400 410 420 430 440 450 pF1KA1 HQKRVFETVRNINQVVKQRSLTPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQKRVFETVRNINQVVKQRSLTPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNV 430 440 450 460 470 480 460 470 480 490 500 510 pF1KA1 VLDNKTNSIILETEAADLGNDERSKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLDNKTNSIILETEAADLGNDERSKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFE 490 500 510 520 530 540 520 530 540 550 560 570 pF1KA1 EEQERKLQELAEKGELRSGSLTPTESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEQERKLQELAEKGELRSGSLTPTESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIV 550 560 570 580 590 600 580 590 600 610 620 630 pF1KA1 KPLEGSATLHHWQQLAQPHLGGILDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPLEGSATLHHWQQLAQPHLGGILDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHI 610 620 630 640 650 660 640 650 pF1KA1 SLPRLATSTPVQHPETS------------------------------------------- ::::::::::::::::: XP_016 SLPRLATSTPVQHPETSGERSQARVTVSGSRSYPSRPQASPEEMQEPPAATEEEEEEEEE 670 680 690 700 710 720 660 670 680 690 700 710 pF1KA1 ---AHHPGKCMSQTNSTFTFTTCRILHPSDELTRVTPSLNSAPTPACGSTSHLKSTPVAT ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGSAHHPGKCMSQTNSTFTFTTCRILHPSDELTRVTPSLNSAPTPACGSTSHLKSTPVAT 730 740 750 760 770 780 720 730 740 750 760 770 pF1KA1 PCTPRRLSLAESFTNTRESTTTMSTSLGLVWLLKERGISAAVYDPQSWDRAGRGSLLHSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PCTPRRLSLAESFTNTRESTTTMSTSLGLVWLLKERGISAAVYDPQSWDRAGRGSLLHSY 790 800 810 820 830 840 780 790 800 810 820 830 pF1KA1 TPKMAVIPSTPPNSPMQTPTSSPPSFEFKCTSPPYDNFLASKPASSILREVREKNVRSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPKMAVIPSTPPNSPMQTPTSSPPSFEFKCTSPPYDNFLASKPASSILREVREKNVRSSE 850 860 870 880 890 900 840 850 860 870 880 890 pF1KA1 SQTDVSVSNLNLVDKVRRFGVAKVVNSGRAHVPTLTEEQGPLLCGPPGPAPALVPRGLVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQTDVSVSNLNLVDKVRRFGVAKVVNSGRAHVPTLTEEQGPLLCGPPGPAPALVPRGLVP 910 920 930 940 950 960 900 910 920 930 940 950 pF1KA1 EGLPLRCPTVTSAIGGLQLNSGIRRNRSFPTMVGSSMQMKAPVTLTSGILMGAKLSKQTS :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGLPLRCPTVTSAIGGLQLNSGIRRNRSFPTMVGSSMQMKAPVTLTSGILMGAKLSKQTS 970 980 990 1000 1010 1020 pF1KA1 LR XP_016 LR >>XP_016861402 (OMIM: 608112) PREDICTED: trafficking kin (691 aa) initn: 4090 init1: 4090 opt: 4090 Z-score: 2434.5 bits: 461.4 E(85289): 7.2e-129 Smith-Waterman score: 4267; 96.9% identity (96.9% similar) in 688 aa overlap (1-688:1-667) 10 20 30 40 50 60 pF1KA1 MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTDLPEVEIISLLEEQLPHYKLRADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTDLPEVEIISLLEEQLPHYKLRADT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 IYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETIT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 YEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 CAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDER 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 SKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 TESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGI 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 LDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSAHHPGK ::::::::::::::::::::::::::::::::: :::::: XP_016 LDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDT---------------------AHHPGK 610 620 630 670 680 690 700 710 720 pF1KA1 CMSQTNSTFTFTTCRILHPSDELTRVTPSLNSAPTPACGSTSHLKSTPVATPCTPRRLSL :::::::::::::::::::::::::::: XP_016 CMSQTNSTFTFTTCRILHPSDELTRVTPRSCEEDDEAAICPVELRGDIGQRV 640 650 660 670 680 690 953 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 10:42:02 2016 done: Thu Nov 3 10:42:04 2016 Total Scan time: 16.200 Total Display time: 0.270 Function used was FASTA [36.3.4 Apr, 2011]