FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1113, 1127 aa 1>>>pF1KA1113 1127 - 1127 aa - 1127 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.3086+/-0.000409; mu= -8.0178+/- 0.026 mean_var=442.2292+/-92.741, 0's: 0 Z-trim(124.0): 137 B-trim: 587 in 1/58 Lambda= 0.060989 statistics sampled from 44528 (44738) to 44528 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.788), E-opt: 0.2 (0.525), width: 16 Scan time: 18.380 The best scores are: opt bits E(85289) NP_056990 (OMIM: 188550,605769) E3 ubiquitin-prote (1127) 7660 689.1 3.9e-197 NP_148980 (OMIM: 188550,605769) E3 ubiquitin-prote (1110) 7098 639.7 2.9e-182 XP_005270994 (OMIM: 188550,605769) PREDICTED: E3 u (1134) 5072 461.4 1.4e-128 XP_016856941 (OMIM: 188550,605769) PREDICTED: E3 u ( 735) 5006 455.5 5.6e-127 XP_005270993 (OMIM: 188550,605769) PREDICTED: E3 u (1151) 4717 430.2 3.5e-119 XP_011539870 (OMIM: 188550,605769) PREDICTED: E3 u (1150) 4709 429.5 5.7e-119 XP_016856942 (OMIM: 188550,605769) PREDICTED: E3 u ( 718) 4444 406.0 4.2e-112 XP_016856943 (OMIM: 188550,605769) PREDICTED: E3 u ( 638) 4227 386.9 2.1e-106 NP_056989 (OMIM: 188550,603406) transcription inte (1050) 2947 274.4 2.5e-72 NP_003843 (OMIM: 188550,603406) transcription inte (1016) 1747 168.8 1.5e-40 NP_005753 (OMIM: 601742) transcription intermediar ( 835) 1172 118.1 2.2e-25 XP_011518827 (OMIM: 612000) PREDICTED: tripartite (1020) 854 90.2 6.7e-17 XP_011518826 (OMIM: 612000) PREDICTED: tripartite (1032) 854 90.2 6.8e-17 XP_011518812 (OMIM: 612000) PREDICTED: tripartite (1364) 854 90.3 8.3e-17 XP_011518811 (OMIM: 612000) PREDICTED: tripartite (1367) 854 90.3 8.3e-17 XP_011518810 (OMIM: 612000) PREDICTED: tripartite (1385) 854 90.4 8.4e-17 XP_011518809 (OMIM: 612000) PREDICTED: tripartite (1392) 854 90.4 8.5e-17 XP_011518806 (OMIM: 612000) PREDICTED: tripartite (1392) 854 90.4 8.5e-17 XP_006718460 (OMIM: 612000) PREDICTED: tripartite (1392) 854 90.4 8.5e-17 XP_016874118 (OMIM: 612000) PREDICTED: tripartite (1392) 854 90.4 8.5e-17 XP_011518815 (OMIM: 612000) PREDICTED: tripartite (1306) 851 90.1 9.7e-17 XP_011518814 (OMIM: 612000) PREDICTED: tripartite (1306) 851 90.1 9.7e-17 XP_016874119 (OMIM: 612000) PREDICTED: tripartite (1306) 851 90.1 9.7e-17 XP_011518816 (OMIM: 612000) PREDICTED: tripartite (1306) 851 90.1 9.7e-17 XP_011518813 (OMIM: 612000) PREDICTED: tripartite (1355) 843 89.4 1.6e-16 NP_055633 (OMIM: 612000) tripartite motif-containi (1216) 812 86.6 9.9e-16 XP_011518817 (OMIM: 612000) PREDICTED: tripartite (1247) 812 86.6 1e-15 XP_006718461 (OMIM: 612000) PREDICTED: tripartite (1247) 812 86.6 1e-15 XP_011518820 (OMIM: 612000) PREDICTED: tripartite (1247) 812 86.6 1e-15 XP_011518819 (OMIM: 612000) PREDICTED: tripartite (1247) 812 86.6 1e-15 XP_011518818 (OMIM: 612000) PREDICTED: tripartite (1247) 812 86.6 1e-15 XP_011518825 (OMIM: 612000) PREDICTED: tripartite (1247) 812 86.6 1e-15 XP_011518821 (OMIM: 612000) PREDICTED: tripartite (1247) 812 86.6 1e-15 XP_011518824 (OMIM: 612000) PREDICTED: tripartite (1247) 812 86.6 1e-15 XP_016874120 (OMIM: 612000) PREDICTED: tripartite (1247) 812 86.6 1e-15 XP_011518829 (OMIM: 612000) PREDICTED: tripartite ( 743) 788 84.3 3e-15 XP_011518828 (OMIM: 612000) PREDICTED: tripartite (1001) 788 84.4 3.7e-15 NP_001139107 (OMIM: 609318) tripartite motif-conta ( 562) 442 53.8 3.5e-06 NP_079464 (OMIM: 609318) tripartite motif-containi ( 580) 442 53.8 3.6e-06 XP_011540501 (OMIM: 609318) PREDICTED: tripartite ( 476) 411 51.0 2e-05 XP_016858742 (OMIM: 608602) PREDICTED: nuclear bod ( 614) 370 47.5 0.0003 NP_001265382 (OMIM: 608602) nuclear body protein S ( 753) 370 47.5 0.00035 XP_016858741 (OMIM: 608602) PREDICTED: nuclear bod ( 756) 370 47.5 0.00035 XP_016858740 (OMIM: 608602) PREDICTED: nuclear bod ( 760) 370 47.5 0.00035 XP_016858739 (OMIM: 608602) PREDICTED: nuclear bod ( 777) 370 47.6 0.00036 XP_016858738 (OMIM: 608602) PREDICTED: nuclear bod ( 780) 370 47.6 0.00036 XP_016858737 (OMIM: 608602) PREDICTED: nuclear bod ( 803) 370 47.6 0.00037 XP_016858736 (OMIM: 608602) PREDICTED: nuclear bod ( 804) 370 47.6 0.00037 XP_005246313 (OMIM: 608602) PREDICTED: nuclear bod ( 806) 370 47.6 0.00037 NP_001265381 (OMIM: 608602) nuclear body protein S ( 807) 370 47.6 0.00037 >>NP_056990 (OMIM: 188550,605769) E3 ubiquitin-protein l (1127 aa) initn: 7660 init1: 7660 opt: 7660 Z-score: 3660.3 bits: 689.1 E(85289): 3.9e-197 Smith-Waterman score: 7660; 99.9% identity (99.9% similar) in 1127 aa overlap (1-1127:1-1127) 10 20 30 40 50 60 pF1KA1 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 SVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 PGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 PGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 TEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKT ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 TEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKI 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 EPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 EPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 CCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 CCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSP 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 VDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 VDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQI 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 PDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 PDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEI 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 pF1KA1 YSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK ::::::::::::::::::::::::::::::::::::::::::::::: NP_056 YSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK 1090 1100 1110 1120 >>NP_148980 (OMIM: 188550,605769) E3 ubiquitin-protein l (1110 aa) initn: 7098 init1: 7098 opt: 7098 Z-score: 3393.1 bits: 639.7 E(85289): 2.9e-182 Smith-Waterman score: 7512; 98.4% identity (98.4% similar) in 1127 aa overlap (1-1127:1-1110) 10 20 30 40 50 60 pF1KA1 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 SVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 SVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 PGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 PGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 TEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKT ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 TEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKI 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 EPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 EPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 CCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 CCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSP 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 VDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 VDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQI 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 PDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEI :::::::::::::::::::: ::::::::::::::::::::::: NP_148 PDDFVADVRLIFKNCERFNE-----------------ADSEVAQAGKAVALYFEDKLTEI 1030 1040 1050 1060 1090 1100 1110 1120 pF1KA1 YSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK ::::::::::::::::::::::::::::::::::::::::::::::: NP_148 YSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK 1070 1080 1090 1100 1110 >>XP_005270994 (OMIM: 188550,605769) PREDICTED: E3 ubiqu (1134 aa) initn: 7084 init1: 4672 opt: 5072 Z-score: 2429.6 bits: 461.4 E(85289): 1.4e-128 Smith-Waterman score: 7454; 96.4% identity (96.4% similar) in 1151 aa overlap (1-1127:1-1134) 10 20 30 40 50 60 pF1KA1 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP 610 620 630 640 650 660 670 680 690 pF1KA1 SVTAIELIPSVTNPENLPSLPDIPPIQ------------------------LEDAGSSSL ::::::::::::::::::::::::::: ::::::::: XP_005 SVTAIELIPSVTNPENLPSLPDIPPIQANVVPMMHSWYEFGAREKTQDQNVLEDAGSSSL 670 680 690 700 710 720 700 710 720 730 740 750 pF1KA1 DNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGS 730 740 750 760 770 780 760 770 780 790 800 810 pF1KA1 SGRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SGRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTP 790 800 810 820 830 840 820 830 840 850 860 870 pF1KA1 PLSTNLHLESELDALASLENHVKTEPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGG ::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::: XP_005 PLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGG 850 860 870 880 890 900 880 890 900 910 920 930 pF1KA1 DGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGK 910 920 930 940 950 960 940 950 960 970 980 990 pF1KA1 PEVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PEVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKI 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KA1 IKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINL :::::::::::::::::::::::::::::::::::::::::::: XP_005 IKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNE---------------- 1030 1040 1050 1060 1060 1070 1080 1090 1100 1110 pF1KA1 KADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKR ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 -ADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKR 1070 1080 1090 1100 1110 1120 1120 pF1KA1 LKSDERPVHIK ::::::::::: XP_005 LKSDERPVHIK 1130 >>XP_016856941 (OMIM: 188550,605769) PREDICTED: E3 ubiqu (735 aa) initn: 5006 init1: 5006 opt: 5006 Z-score: 2400.7 bits: 455.5 E(85289): 5.6e-127 Smith-Waterman score: 5006; 99.9% identity (99.9% similar) in 735 aa overlap (393-1127:1-735) 370 380 390 400 410 420 pF1KA1 KVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS :::::::::::::::::::::::::::::: XP_016 MKLLQQQNDITGLSRQVKHVMNFTNWAIAS 10 20 30 430 440 450 460 470 480 pF1KA1 GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKP 40 50 60 70 80 90 490 500 510 520 530 540 pF1KA1 APGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAP 100 110 120 130 140 150 550 560 570 580 590 600 pF1KA1 VPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI 160 170 180 190 200 210 610 620 630 640 650 660 pF1KA1 PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSV 220 230 240 250 260 270 670 680 690 700 710 720 pF1KA1 TAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPG 280 290 300 310 320 330 730 740 750 760 770 780 pF1KA1 PSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE 340 350 360 370 380 390 790 800 810 820 830 840 pF1KA1 DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKTEP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_016 DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEP 400 410 420 430 440 450 850 860 870 880 890 900 pF1KA1 ADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLLCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLLCC 460 470 480 490 500 510 910 920 930 940 950 960 pF1KA1 EKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD 520 530 540 550 560 570 970 980 990 1000 1010 1020 pF1KA1 QRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPD 580 590 600 610 620 630 1030 1040 1050 1060 1070 1080 pF1KA1 DFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEIYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEIYS 640 650 660 670 680 690 1090 1100 1110 1120 pF1KA1 DRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK ::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK 700 710 720 730 >>XP_005270993 (OMIM: 188550,605769) PREDICTED: E3 ubiqu (1151 aa) initn: 7646 init1: 4672 opt: 4717 Z-score: 2260.7 bits: 430.2 E(85289): 3.5e-119 Smith-Waterman score: 7602; 97.8% identity (97.8% similar) in 1151 aa overlap (1-1127:1-1151) 10 20 30 40 50 60 pF1KA1 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP 610 620 630 640 650 660 670 680 690 pF1KA1 SVTAIELIPSVTNPENLPSLPDIPPIQ------------------------LEDAGSSSL ::::::::::::::::::::::::::: ::::::::: XP_005 SVTAIELIPSVTNPENLPSLPDIPPIQANVVPMMHSWYEFGAREKTQDQNVLEDAGSSSL 670 680 690 700 710 720 700 710 720 730 740 750 pF1KA1 DNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGS 730 740 750 760 770 780 760 770 780 790 800 810 pF1KA1 SGRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SGRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTP 790 800 810 820 830 840 820 830 840 850 860 870 pF1KA1 PLSTNLHLESELDALASLENHVKTEPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGG ::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::: XP_005 PLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGG 850 860 870 880 890 900 880 890 900 910 920 930 pF1KA1 DGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGK 910 920 930 940 950 960 940 950 960 970 980 990 pF1KA1 PEVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PEVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKI 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KA1 IKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINL 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KA1 KADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKR 1090 1100 1110 1120 1130 1140 1120 pF1KA1 LKSDERPVHIK ::::::::::: XP_005 LKSDERPVHIK 1150 >>XP_011539870 (OMIM: 188550,605769) PREDICTED: E3 ubiqu (1150 aa) initn: 7646 init1: 4672 opt: 4709 Z-score: 2256.9 bits: 429.5 E(85289): 5.7e-119 Smith-Waterman score: 7604; 97.9% identity (97.9% similar) in 1150 aa overlap (1-1127:1-1150) 10 20 30 40 50 60 pF1KA1 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP 610 620 630 640 650 660 670 680 690 pF1KA1 SVTAIELIPSVTNPENLPSLPDIPPIQ-----------------------LEDAGSSSLD ::::::::::::::::::::::::::: :::::::::: XP_011 SVTAIELIPSVTNPENLPSLPDIPPIQANVVPMMHSWYEFGAREKTQDQNLEDAGSSSLD 670 680 690 700 710 720 700 710 720 730 740 750 pF1KA1 NLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSS 730 740 750 760 770 780 760 770 780 790 800 810 pF1KA1 GRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPP 790 800 810 820 830 840 820 830 840 850 860 870 pF1KA1 LSTNLHLESELDALASLENHVKTEPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGD :::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::: XP_011 LSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGD 850 860 870 880 890 900 880 890 900 910 920 930 pF1KA1 GNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKP 910 920 930 940 950 960 940 950 960 970 980 990 pF1KA1 EVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKII 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KA1 KKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLK 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KA1 ADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRL 1090 1100 1110 1120 1130 1140 1120 pF1KA1 KSDERPVHIK :::::::::: XP_011 KSDERPVHIK 1150 >>XP_016856942 (OMIM: 188550,605769) PREDICTED: E3 ubiqu (718 aa) initn: 4444 init1: 4444 opt: 4444 Z-score: 2133.6 bits: 406.0 E(85289): 4.2e-112 Smith-Waterman score: 4858; 97.6% identity (97.6% similar) in 735 aa overlap (393-1127:1-718) 370 380 390 400 410 420 pF1KA1 KVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS :::::::::::::::::::::::::::::: XP_016 MKLLQQQNDITGLSRQVKHVMNFTNWAIAS 10 20 30 430 440 450 460 470 480 pF1KA1 GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKP 40 50 60 70 80 90 490 500 510 520 530 540 pF1KA1 APGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAP 100 110 120 130 140 150 550 560 570 580 590 600 pF1KA1 VPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI 160 170 180 190 200 210 610 620 630 640 650 660 pF1KA1 PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSV 220 230 240 250 260 270 670 680 690 700 710 720 pF1KA1 TAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPG 280 290 300 310 320 330 730 740 750 760 770 780 pF1KA1 PSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE 340 350 360 370 380 390 790 800 810 820 830 840 pF1KA1 DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKTEP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_016 DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEP 400 410 420 430 440 450 850 860 870 880 890 900 pF1KA1 ADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLLCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLLCC 460 470 480 490 500 510 910 920 930 940 950 960 pF1KA1 EKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD 520 530 540 550 560 570 970 980 990 1000 1010 1020 pF1KA1 QRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPD 580 590 600 610 620 630 1030 1040 1050 1060 1070 1080 pF1KA1 DFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEIYS :::::::::::::::::: ::::::::::::::::::::::::: XP_016 DFVADVRLIFKNCERFNE-----------------ADSEVAQAGKAVALYFEDKLTEIYS 640 650 660 670 1090 1100 1110 1120 pF1KA1 DRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK ::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK 680 690 700 710 >>XP_016856943 (OMIM: 188550,605769) PREDICTED: E3 ubiqu (638 aa) initn: 4220 init1: 4220 opt: 4227 Z-score: 2031.1 bits: 386.9 E(85289): 2.1e-106 Smith-Waterman score: 4227; 98.0% identity (98.3% similar) in 638 aa overlap (1-631:1-638) 10 20 30 40 50 60 pF1KA1 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP 550 560 570 580 590 600 610 620 630 640 650 pF1KA1 GIPRHSGPQYSMMQPHLQRQ-----H--SNPGHAGPFPVVSVHNTTINPTSPTTATMANA :::::::::::::::::::: : .. : ::: XP_016 GIPRHSGPQYSMMQPHLQRQVCLELHFTQTQGMLDPFP 610 620 630 660 670 680 690 700 710 pF1KA1 NRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQP >>NP_056989 (OMIM: 188550,603406) transcription intermed (1050 aa) initn: 2703 init1: 1139 opt: 2947 Z-score: 1419.5 bits: 274.4 E(85289): 2.5e-72 Smith-Waterman score: 3335; 50.1% identity (72.1% similar) in 1108 aa overlap (67-1122:3-1046) 40 50 60 70 80 90 pF1KA1 PLTAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVST ::. .. .: ::.: ::: :: .. NP_056 MEVAVEKAVAAAAAASAAAS------GGPSAA 10 20 100 110 120 130 140 150 pF1KA1 PAPAPASAPAPGPSAGPPPGPPA--SLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCL :. . ::.. : : .::::::::.:..::: ::::::::::: ::: NP_056 PSGENEAESRQGPDS-ERGGEAARLNLLDTCAVCHQNIQSR---APKLLPCLHSFCQRCL 30 40 50 60 70 80 160 170 180 190 pF1KA1 PEPERQL--------------SVPIPG----GSNGDIQQVGVIRCPVCRQECRQIDLVDN : :.: : :: :: ::. :::::::::: ::: . ..:: NP_056 PAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHIIDN 90 100 110 120 130 140 200 210 220 230 240 250 pF1KA1 YFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLI .:::::.:.:::. :::.:::::::::: : :::::: ::::::::.::::::::::: . NP_056 FFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTV 150 160 170 180 190 200 260 270 280 290 300 310 pF1KA1 RKKEDVS-ESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEA :.::.:: :.::...::::::: ::.:::::.:::::.::::::::::::::::::.::: NP_056 RQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEA 210 220 230 240 250 260 320 330 340 350 360 370 pF1KA1 FQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINK ::::: :..:..::.:: .:..:...:.:::: :::...:.:::.::::::::. :::: NP_056 FQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVEINK 270 280 290 300 310 320 380 390 400 410 420 430 pF1KA1 KGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLI :::.::.:::...:...:::.:::....:::.:..:::.:..::..:::::::::::::: NP_056 KGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLI 330 340 350 360 370 380 440 450 460 470 480 490 pF1KA1 TFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTP--NVVVG :..:::.:.:::: :..:..:.:::::.:::.:..:::.::::.: . : : :: NP_056 TYRLRHLLRARCDASPVTNNTIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVE 390 400 410 420 430 440 500 510 520 530 540 pF1KA1 QV--PPG---TNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTT : ::. .:..:: : ::.:::::::::::::.::..: .:. :::: . NP_056 QNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQRQQ------VQRRPAPVGLPNP 450 460 470 480 490 550 560 570 580 590 600 pF1KA1 TTQQHPRQAAPQMLQQQPPRLISVQTMQ-RGNMNCGAFQAHQMRLAQNAARIPGIPRHS- .: : : :: :::::. :. . . : . .:.: : .:::.. NP_056 R-MQGPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQ----NIPRQAI 500 510 520 530 540 550 610 620 630 640 650 660 pF1KA1 --GP-QYSMM-QPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANAN-RGPTSPS .: :.... : ... . . :.. : ....:. .:.::: .. :. . .. :: NP_056 KPNPLQMAFLAQQAIKQWQISSGQGTP---STTNSTSSTPSSPTITSAAGYDGKAFGSP- 560 570 580 590 600 670 680 690 700 710 pF1KA1 VTAIELIPSVTNPENLPSLPDIPPIQLEDAGSS-SLDNLLSRYISGSHLPPQPTSTMN-P :.: : . :::::::: : .:. :::.. . . .: :.: :. . NP_056 --MIDLSSPVGGSYNLPSLPDI------DCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQ 610 620 630 640 650 720 730 740 750 760 770 pF1KA1 SPGPSALSPGSSG---LSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLS----FKSDQ ::. :. ::: .: ... : :.: ::.::.::::: :::.. : : . NP_056 SPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEP 660 670 680 690 700 710 780 790 800 810 820 830 pF1KA1 VKVKQEPGTEDEICSFSGG-VKQEKTEDGRRSACMLSSPESSLTP-PLSTNLHLESELDA ...::: . : .: ::::. :..: :... : . :.: :.: .. NP_056 IRIKQENSGPPENYDFPVVIVKQESDEESR--------PQNANYPRSILTSLLLNSSQSS 720 730 740 750 760 770 840 850 860 870 880 pF1KA1 LASLENHVKTEPADMNESCKQSGL--SSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNED .: :. .... : . : :: .. :::: . ..: :. . :.:::::: NP_056 -TSEETVLRSDAPD--STGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGE-TRKEDDPNED 780 790 800 810 820 890 900 910 920 930 940 pF1KA1 WCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQH :::::::::.:::::::::::::.:::::: .::::.::::::::..::::::::: .: NP_056 WCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSH 830 840 850 860 870 880 950 960 970 980 990 1000 pF1KA1 SKKGKTAQGL---SPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLST ... : ..:: .:.:.::::::::.:::::.:. ::.::: ..:.::::::.:::::: NP_056 NSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLST 890 900 910 920 930 940 1010 1020 1030 1040 1050 1060 pF1KA1 VKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQA .::.::. .:. :. :.::::: ::::.:: .::: :::::.: NP_056 IKKRLQEDYSM-YSKPEDFVADFRLIFQNCAEFNE-----------------PDSEVANA 950 960 970 980 1070 1080 1090 1100 1110 1120 pF1KA1 GKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKS-DERPV : . :::. : ..: .. : : :::..: .:.. ..:::.::.:::.::::: .:: NP_056 GIKLENYFEELLKNLYPEKRF-PKPEFRNESEDNKFSDDSDDDFVQPRKKRLKSIEERQL 990 1000 1010 1020 1030 1040 pF1KA1 HIK NP_056 LK 1050 >>NP_003843 (OMIM: 188550,603406) transcription intermed (1016 aa) initn: 2873 init1: 1092 opt: 1747 Z-score: 849.1 bits: 168.8 E(85289): 1.5e-40 Smith-Waterman score: 3219; 49.0% identity (70.6% similar) in 1107 aa overlap (67-1122:3-1012) 40 50 60 70 80 90 pF1KA1 PLTAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVST ::. .. .: ::.: ::: :: .. NP_003 MEVAVEKAVAAAAAASAAAS------GGPSAA 10 20 100 110 120 130 140 150 pF1KA1 PAPAPASAPAPGPSAGPPPGPPA--SLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCL :. . ::.. : : .::::::::.:..::: ::::::::::: ::: NP_003 PSGENEAESRQGPDS-ERGGEAARLNLLDTCAVCHQNIQSR---APKLLPCLHSFCQRCL 30 40 50 60 70 80 160 170 180 190 pF1KA1 PEPERQL--------------SVPIPG----GSNGDIQQVGVIRCPVCRQECRQIDLVDN : :.: : :: :: ::. :::::::::: ::: . ..:: NP_003 PAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHIIDN 90 100 110 120 130 140 200 210 220 230 240 250 pF1KA1 YFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLI .:::::.:.:::. :::.:::::::::: : :::::: ::::::::.::::::::::: . NP_003 FFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTV 150 160 170 180 190 200 260 270 280 290 300 310 pF1KA1 RKKEDVS-ESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEA :.::.:: :.::...::::::: ::.:::::.:::::.::::::::::::::::::.::: NP_003 RQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEA 210 220 230 240 250 260 320 330 340 350 360 370 pF1KA1 FQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINK ::::: :..:..::.:: .:..:...:.:::: :::...:.:::.::::::::. :::: NP_003 FQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVEINK 270 280 290 300 310 320 380 390 400 410 420 430 pF1KA1 KGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLI :::.::.:::...:...:::.:::....:::.:..:::.:..::..:::::::::::::: NP_003 KGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLI 330 340 350 360 370 380 440 450 460 470 480 490 pF1KA1 TFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTP--NVVVG :..:::.:.:::: :..:..:.:::::.:::.:..:::.::::.: . : : :: NP_003 TYRLRHLLRARCDASPVTNNTIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVE 390 400 410 420 430 440 500 510 520 530 540 pF1KA1 QV--PPG---TNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTT : ::. .:..:: : ::.:::::::::::: ::: : . NP_003 QNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQ---------------QPP---PRLIN 450 460 470 480 550 560 570 580 590 600 pF1KA1 TTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHS-- .. :. .: . :: . .:.: : .:::.. NP_003 FQNHSPKPNGPVL----PP------------------HPQQLRYPPNQ----NIPRQAIK 490 500 510 610 620 630 640 650 660 pF1KA1 -GP-QYSMM-QPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANAN-RGPTSPSV .: :.... : ... . . :.. : ....:. .:.::: .. :. . .. :: NP_003 PNPLQMAFLAQQAIKQWQISSGQGTP---STTNSTSSTPSSPTITSAAGYDGKAFGSP-- 520 530 540 550 560 570 670 680 690 700 710 720 pF1KA1 TAIELIPSVTNPENLPSLPDIPPIQLEDAGSS-SLDNLLSRYISGSHLPPQPTSTMN-PS :.: : . :::::::: : .:. :::.. . . .: :.: :. . : NP_003 -MIDLSSPVGGSYNLPSLPDI------DCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQS 580 590 600 610 620 730 740 750 760 770 pF1KA1 PGPSALSPGSSG---LSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLS----FKSDQV :. :. ::: .: ... : :.: ::.::.::::: :::.. : : . . NP_003 PNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPI 630 640 650 660 670 680 780 790 800 810 820 830 pF1KA1 KVKQEPGTEDEICSFSGG-VKQEKTEDGRRSACMLSSPESSLTP-PLSTNLHLESELDAL ..::: . : .: ::::. :..: :... : . :.: :.: .. NP_003 RIKQENSGPPENYDFPVVIVKQESDEESR--------PQNANYPRSILTSLLLNSSQSS- 690 700 710 720 730 840 850 860 870 880 pF1KA1 ASLENHVKTEPADMNESCKQSGL--SSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDW .: :. .... : . : :: .. :::: . ..: :. . :.::::::: NP_003 TSEETVLRSDAPD--STGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGE-TRKEDDPNEDW 740 750 760 770 780 790 890 900 910 920 930 940 pF1KA1 CAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHS ::::::::.:::::::::::::.:::::: .::::.::::::::..::::::::: .:. NP_003 CAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHN 800 810 820 830 840 850 950 960 970 980 990 1000 pF1KA1 KKGKTAQGL---SPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTV .. : ..:: .:.:.::::::::.:::::.:. ::.::: ..:.::::::.::::::. NP_003 SEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTI 860 870 880 890 900 910 1010 1020 1030 1040 1050 1060 pF1KA1 KKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAG ::.::. .:. :. :.::::: ::::.:: .::: :::::.:: NP_003 KKRLQEDYSM-YSKPEDFVADFRLIFQNCAEFNE-----------------PDSEVANAG 920 930 940 950 1070 1080 1090 1100 1110 1120 pF1KA1 KAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKS-DERPVH . :::. : ..: .. : : :::..: .:.. ..:::.::.:::.::::: .:: NP_003 IKLENYFEELLKNLYPEKRF-PKPEFRNESEDNKFSDDSDDDFVQPRKKRLKSIEERQLL 960 970 980 990 1000 1010 pF1KA1 IK NP_003 K 1127 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 19:52:48 2016 done: Thu Nov 3 19:52:51 2016 Total Scan time: 18.380 Total Display time: 0.380 Function used was FASTA [36.3.4 Apr, 2011]