FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1159, 252 aa 1>>>pF1KA1159 252 - 252 aa - 252 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.8409+/-0.000288; mu= 9.0028+/- 0.018 mean_var=129.9989+/-26.781, 0's: 0 Z-trim(122.3): 6 B-trim: 1439 in 1/53 Lambda= 0.112488 statistics sampled from 40332 (40338) to 40332 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.805), E-opt: 0.2 (0.473), width: 16 Scan time: 7.530 The best scores are: opt bits E(85289) NP_009156 (OMIM: 604636) neurexophilin-3 precursor ( 252) 1794 301.4 1e-81 NP_689958 (OMIM: 604639) neurexophilin-1 precursor ( 271) 847 147.7 1.9e-35 NP_009157 (OMIM: 604635) neurexophilin-2 precursor ( 264) 815 142.5 7e-34 NP_009155 (OMIM: 604637) neurexophilin-4 precursor ( 308) 375 71.2 2.5e-12 XP_016874236 (OMIM: 604637) PREDICTED: neurexophil ( 223) 182 39.8 0.0051 >>NP_009156 (OMIM: 604636) neurexophilin-3 precursor [Ho (252 aa) initn: 1794 init1: 1794 opt: 1794 Z-score: 1588.2 bits: 301.4 E(85289): 1e-81 Smith-Waterman score: 1794; 100.0% identity (100.0% similar) in 252 aa overlap (1-252:1-252) 10 20 30 40 50 60 pF1KA1 MQLTRCCFVFLVQGSLYLVICGQDDGPPGSEDPERDDHEGQPRPRVPRKRGHISPKSRPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 MQLTRCCFVFLVQGSLYLVICGQDDGPPGSEDPERDDHEGQPRPRVPRKRGHISPKSRPM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 ANSTLLGLLAPPGEAWGILGQPPNRPNHSPPPSAKVKKIFGWGDFYSNIKTVALNLLVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 ANSTLLGLLAPPGEAWGILGQPPNRPNHSPPPSAKVKKIFGWGDFYSNIKTVALNLLVTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 KIVDHGNGTFSVHFQHNATGQGNISISLVPPSKAVEFHQEQQIFIEAKASKIFNCRMEWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 KIVDHGNGTFSVHFQHNATGQGNISISLVPPSKAVEFHQEQQIFIEAKASKIFNCRMEWE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 KVERGRRTSLCTHDPAKICSRDHAQSSATWSCSQPFKVVCVYIAFYSTDYRLVQKVCPDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 KVERGRRTSLCTHDPAKICSRDHAQSSATWSCSQPFKVVCVYIAFYSTDYRLVQKVCPDY 190 200 210 220 230 240 250 pF1KA1 NYHSDTPYYPSG :::::::::::: NP_009 NYHSDTPYYPSG 250 >>NP_689958 (OMIM: 604639) neurexophilin-1 precursor [Ho (271 aa) initn: 906 init1: 838 opt: 847 Z-score: 757.2 bits: 147.7 E(85289): 1.9e-35 Smith-Waterman score: 847; 65.1% identity (86.9% similar) in 175 aa overlap (79-252:97-271) 50 60 70 80 90 100 pF1KA1 KRGHISPKSRPMANSTLLGLLAPPGEAWGILGQPPNRPNHSPP-PSAKVKKIFGWGDFYS : .: : .. : ..: ::.::::::.: NP_689 ENDTDLDLRYDTPEPYSEQDLWDWLRNSTDLQEPRPRAKRRPIVKTGKFKKMFGWGDFHS 70 80 90 100 110 120 110 120 130 140 150 160 pF1KA1 NIKTVALNLLVTGKIVDHGNGTFSVHFQHNATGQGNISISLVPPSKAVEFHQEQQIFIEA ::::: ::::.::::::::::::::.:.::.:::::.:.:::::.: ::: :: :.: NP_689 NIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGQGNVSVSLVPPTKIVEFDLAQQTVIDA 130 140 150 160 170 180 170 180 190 200 210 220 pF1KA1 KASKIFNCRMEWEKVERGRRTSLCTHDPAKICSRDHAQSSATWSCSQPFKVVCVYIAFYS : :: ::::.:.:::... ...::..::.: : ....:: ..: ::.::::.:.::.::: NP_689 KDSKSFNCRIEYEKVDKATKNTLCNYDPSKTCYQEQTQSHVSWLCSKPFKVICIYISFYS 190 200 210 220 230 240 230 240 250 pF1KA1 TDYRLVQKVCPDYNYHSDTPYYPSG :::.:::::::::::::::::.::: NP_689 TDYKLVQKVCPDYNYHSDTPYFPSG 250 260 270 >>NP_009157 (OMIM: 604635) neurexophilin-2 precursor [Ho (264 aa) initn: 826 init1: 806 opt: 815 Z-score: 729.3 bits: 142.5 E(85289): 7e-34 Smith-Waterman score: 822; 50.8% identity (72.3% similar) in 256 aa overlap (11-252:10-264) 10 20 30 40 50 pF1KA1 MQLTRCCFVFLVQGSLYLVICGQDDGPPGSE--DPERDDHEGQPRPRVPRKRGHISP--- .: : : :..: . . ..: : : : : : ..: ::: NP_009 MRLRPLPLVVVPGLLQLLFCDSKEVVHATEGLDWEDKDAPGTLVGNVVHSRI-ISPLRL 10 20 30 40 50 60 70 80 90 100 pF1KA1 --KSRPMANSTLLGLLAPPGEAWGILG------QPPNRPNHSPP-PSAKVKKIFGWGDFY :. :. . .. . : :. .: : .. : ..: ::.::::::. NP_009 FVKQSPVPKPGPMAYADSMENFWDWLANITEIQEPLARTKRRPIVKTGKFKKMFGWGDFH 60 70 80 90 100 110 110 120 130 140 150 160 pF1KA1 SNIKTVALNLLVTGKIVDHGNGTFSVHFQHNATGQGNISISLVPPSKAVEFHQEQQIFIE :::::: ::::.::::::::::::::.:.::.:: ::.:.:::::::.:::. : .: NP_009 SNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGLGNVSVSLVPPSKVVEFEVSPQSTLE 120 130 140 150 160 170 170 180 190 200 210 220 pF1KA1 AKASKIFNCRMEWEKVERGRRTSLCTHDPAKICSRDHAQSSATWSCSQPFKVVCVYIAFY .: :: ::::.:.::..:...:.::. ::.::: ....:: ..: ::.::::.:.::::: NP_009 TKESKSFNCRIEYEKTDRAKKTALCNFDPSKICYQEQTQSHVSWLCSKPFKVICIYIAFY 180 190 200 210 220 230 230 240 250 pF1KA1 STDYRLVQKVCPDYNYHSDTPYYPSG :.::.:::::::::::::.::: :: NP_009 SVDYKLVQKVCPDYNYHSETPYLSSG 240 250 260 >>NP_009155 (OMIM: 604637) neurexophilin-4 precursor [Ho (308 aa) initn: 693 init1: 375 opt: 375 Z-score: 342.5 bits: 71.2 E(85289): 2.5e-12 Smith-Waterman score: 598; 39.7% identity (59.9% similar) in 277 aa overlap (26-249:44-307) 10 20 30 40 50 pF1KA1 MQLTRCCFVFLVQGSLYLVICGQDDGPPGSEDPERDDHEGQPRPRVPRKRGHISP : ::.. :: :: :. NP_009 PWLLRKAVSAQIPESGRPQYLGLRPAAAGAGAPGQQLPE-------PRSSDGLGVGRAWS 20 30 40 50 60 60 70 80 90 100 110 pF1KA1 KSRPMANSTLLGLLAPPGEAWGILGQPPNRPNHSPP-PSAKVKKIFGWGDFYSNIKTVAL . : .: : : :: : : : : : .: ...: .:..:::::::::: ..:. . NP_009 WAWP-TNHT--GALARAGAA-GAL--PAQRTKRKPSIKAARAKKIFGWGDFYFRVHTLKF 70 80 90 100 110 120 120 130 140 150 160 pF1KA1 NLLVTGKIVDHGNGTFSVHFQHNATGQGNISISLVPPSKAVEF----------HQEQQIF .:::::::::: ::::::.:.::... ::.:.:.::::: ::: : :. . NP_009 SLLVTGKIVDHVNGTFSVYFRHNSSSLGNLSVSIVPPSKRVEFGGVWLPGPVPHPLQSTL 130 140 150 160 170 180 170 180 pF1KA1 -IE-----------------------------------------AKASKIFNCRMEWEKV .: :: :. :::..:.::. NP_009 ALEGVLPGLGPPLGMAAAAAGPGLGGSLGGALAGPLGGALGVPGAKESRAFNCHVEYEKT 190 200 210 220 230 240 190 200 210 220 230 240 pF1KA1 ERGRRTSLCTHDPAKICSRDHAQSSATWSCSQPFKVVCVYIAFYSTDYRLVQKVCPDYNY .:.:. : .::...: .:.::.:.: :..::::.:....: : ::.::::::::::. NP_009 NRARKHRPCLYDPSQVCFTEHTQSQAAWLCAKPFKVICIFVSFLSFDYKLVQKVCPDYNF 250 260 270 280 290 300 250 pF1KA1 HSDTPYYPSG .:. ::. NP_009 QSEHPYFG >>XP_016874236 (OMIM: 604637) PREDICTED: neurexophilin-4 (223 aa) initn: 177 init1: 152 opt: 182 Z-score: 175.1 bits: 39.8 E(85289): 0.0051 Smith-Waterman score: 190; 40.8% identity (58.3% similar) in 103 aa overlap (26-127:44-133) 10 20 30 40 50 pF1KA1 MQLTRCCFVFLVQGSLYLVICGQDDGPPGSEDPERDDHEGQPRPRVPRKRGHISP : ::.. :: :: :. XP_016 PWLLRKAVSAQIPESGRPQYLGLRPAAAGAGAPGQQLPE-------PRSSDGLGVGRAWS 20 30 40 50 60 60 70 80 90 100 110 pF1KA1 KSRPMANSTLLGLLAPPGEAWGILGQPPNRPNHSPP-PSAKVKKIFGWGDFYSNIKTVAL . : .. : :: : : : : : .: ...: .:..:::::::::: ..:. . XP_016 WAWPTNHT---GALARAGAA-GAL--PAQRTKRKPSIKAARAKKIFGWGDFYFRVHTLKF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA1 NLLVTGKIVDHGNGTFSVHFQHNATGQGNISISLVPPSKAVEFHQEQQIFIEAKASKIFN .:::::::::: : XP_016 SLLVTGKIVDHVNALTTNWCRRCAQTITSRVSTPTSDSAPPQPVLSLPPNPSLTRWDPLP 130 140 150 160 170 180 252 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 19:54:01 2016 done: Thu Nov 3 19:54:03 2016 Total Scan time: 7.530 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]