FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1168, 1278 aa 1>>>pF1KA1168 1278 - 1278 aa - 1278 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5656+/-0.00106; mu= 21.1174+/- 0.064 mean_var=67.6910+/-13.225, 0's: 0 Z-trim(102.3): 29 B-trim: 0 in 0/49 Lambda= 0.155887 statistics sampled from 6876 (6886) to 6876 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.557), E-opt: 0.2 (0.212), width: 16 Scan time: 3.860 The best scores are: opt bits E(32554) CCDS78077.1 CYFIP2 gene_id:26999|Hs108|chr5 (1278) 8589 1941.6 0 CCDS78078.1 CYFIP2 gene_id:26999|Hs108|chr5 (1227) 4691 1065.0 0 CCDS75364.1 CYFIP2 gene_id:26999|Hs108|chr5 (1253) 4691 1065.0 0 CCDS73695.1 CYFIP1 gene_id:23191|Hs108|chr15 ( 822) 4101 932.2 0 CCDS73696.1 CYFIP1 gene_id:23191|Hs108|chr15 (1253) 4101 932.3 0 >>CCDS78077.1 CYFIP2 gene_id:26999|Hs108|chr5 (1278 aa) initn: 8589 init1: 8589 opt: 8589 Z-score: 10427.5 bits: 1941.6 E(32554): 0 Smith-Waterman score: 8589; 99.9% identity (100.0% similar) in 1278 aa overlap (1-1278:1-1278) 10 20 30 40 50 60 pF1KA1 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 QLQVVPLFGDMQIELARYIETSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: CCDS78 QLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 SELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 SELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 KFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 KFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 GFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 GFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSGS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 KKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 KKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRI 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 QFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 QFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVN 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 LCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 LCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHM 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 TLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 TLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQ 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 RDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 RDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKI 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 VKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 VKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 LREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 LREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA1 LHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 LHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTN 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA1 GVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 GVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA1 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTV 1210 1220 1230 1240 1250 1260 1270 pF1KA1 EHVRCFQPPIHQSLATTC :::::::::::::::::: CCDS78 EHVRCFQPPIHQSLATTC 1270 >>CCDS78078.1 CYFIP2 gene_id:26999|Hs108|chr5 (1227 aa) initn: 7741 init1: 4690 opt: 4691 Z-score: 5690.0 bits: 1065.0 E(32554): 0 Smith-Waterman score: 8091; 95.9% identity (96.0% similar) in 1278 aa overlap (1-1278:1-1227) 10 20 30 40 50 60 pF1KA1 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT ::::::::: ::::::::::::::::::::::::: CCDS78 EQATVHSSM--------------------------VKCNEQPNRVEIYEKTVEVLEPEVT 70 80 90 130 140 150 160 170 180 pF1KA1 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS 100 110 120 130 140 150 190 200 210 220 230 240 pF1KA1 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD 160 170 180 190 200 210 250 260 270 280 290 300 pF1KA1 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK 220 230 240 250 260 270 310 320 330 340 350 360 pF1KA1 QLQVVPLFGDMQIELARYIETSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: CCDS78 QLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI 280 290 300 310 320 330 370 380 390 400 410 420 pF1KA1 SELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 SELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTD 340 350 360 370 380 390 430 440 450 460 470 480 pF1KA1 KFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 KFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY 400 410 420 430 440 450 490 500 510 520 530 540 pF1KA1 AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKG 460 470 480 490 500 510 550 560 570 580 590 600 pF1KA1 GFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSGS ::::::::::::::::: :::::::::::::::::: CCDS78 GFDIKVPRRAVGPSSTQ-------------------------LYMVRTMLESLIADKSGS 520 530 540 610 620 630 640 650 660 pF1KA1 KKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 KKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRI 550 560 570 580 590 600 670 680 690 700 710 720 pF1KA1 QFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 QFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVN 610 620 630 640 650 660 730 740 750 760 770 780 pF1KA1 LCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 LCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQ 670 680 690 700 710 720 790 800 810 820 830 840 pF1KA1 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHM 730 740 750 760 770 780 850 860 870 880 890 900 pF1KA1 TLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 TLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQ 790 800 810 820 830 840 910 920 930 940 950 960 pF1KA1 RDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 RDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKI 850 860 870 880 890 900 970 980 990 1000 1010 1020 pF1KA1 VKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 VKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQS 910 920 930 940 950 960 1030 1040 1050 1060 1070 1080 pF1KA1 LREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 LREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAP 970 980 990 1000 1010 1020 1090 1100 1110 1120 1130 1140 pF1KA1 LHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 LHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTN 1030 1040 1050 1060 1070 1080 1150 1160 1170 1180 1190 1200 pF1KA1 GVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 GVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL 1090 1100 1110 1120 1130 1140 1210 1220 1230 1240 1250 1260 pF1KA1 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTV 1150 1160 1170 1180 1190 1200 1270 pF1KA1 EHVRCFQPPIHQSLATTC :::::::::::::::::: CCDS78 EHVRCFQPPIHQSLATTC 1210 1220 >>CCDS75364.1 CYFIP2 gene_id:26999|Hs108|chr5 (1253 aa) initn: 8382 init1: 4690 opt: 4691 Z-score: 5689.8 bits: 1065.0 E(32554): 0 Smith-Waterman score: 8336; 98.0% identity (98.0% similar) in 1278 aa overlap (1-1278:1-1253) 10 20 30 40 50 60 pF1KA1 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 QLQVVPLFGDMQIELARYIETSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: CCDS75 QLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 SELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 SELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 KFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 KFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 GFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSGS ::::::::::::::::: :::::::::::::::::: CCDS75 GFDIKVPRRAVGPSSTQ-------------------------LYMVRTMLESLIADKSGS 550 560 570 610 620 630 640 650 660 pF1KA1 KKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 KKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRI 580 590 600 610 620 630 670 680 690 700 710 720 pF1KA1 QFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 QFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVN 640 650 660 670 680 690 730 740 750 760 770 780 pF1KA1 LCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 LCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQ 700 710 720 730 740 750 790 800 810 820 830 840 pF1KA1 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHM 760 770 780 790 800 810 850 860 870 880 890 900 pF1KA1 TLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 TLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQ 820 830 840 850 860 870 910 920 930 940 950 960 pF1KA1 RDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 RDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKI 880 890 900 910 920 930 970 980 990 1000 1010 1020 pF1KA1 VKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 VKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQS 940 950 960 970 980 990 1030 1040 1050 1060 1070 1080 pF1KA1 LREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 LREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAP 1000 1010 1020 1030 1040 1050 1090 1100 1110 1120 1130 1140 pF1KA1 LHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 LHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTN 1060 1070 1080 1090 1100 1110 1150 1160 1170 1180 1190 1200 pF1KA1 GVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 GVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL 1120 1130 1140 1150 1160 1170 1210 1220 1230 1240 1250 1260 pF1KA1 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTV 1180 1190 1200 1210 1220 1230 1270 pF1KA1 EHVRCFQPPIHQSLATTC :::::::::::::::::: CCDS75 EHVRCFQPPIHQSLATTC 1240 1250 >>CCDS73695.1 CYFIP1 gene_id:23191|Hs108|chr15 (822 aa) initn: 4131 init1: 4101 opt: 4101 Z-score: 4975.6 bits: 932.2 E(32554): 0 Smith-Waterman score: 4101; 85.8% identity (96.1% similar) in 695 aa overlap (583-1277:128-822) 560 570 580 590 600 610 pF1KA1 PSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSGSKKTLRSSLDGPI ::::::::::::::::::::::::::.:: CCDS73 QSFSHGLFEFGITNVPCIFSPPQMFPWIIQLYMVRTMLESLIADKSGSKKTLRSSLEGPT 100 110 120 130 140 150 620 630 640 650 660 670 pF1KA1 VLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWIL .: :: ::..:::.:::.:.::.::::::::::::::::::::::::::::::::::::: CCDS73 ILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWIL 160 170 180 190 200 210 680 690 700 710 720 730 pF1KA1 TDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKLAD ::::::::: :::::::: ::::::::.::::.:.::::::::::::::::::::::::: CCDS73 TDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLAD 220 230 240 250 260 270 740 750 760 770 780 790 pF1KA1 QIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQLLGRSIDLNRLI :::::::.::::.:::::.:.:::: :. : :::::::::::::::::::::::::::: CCDS73 QIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLI 280 290 300 310 320 330 800 810 820 830 840 850 pF1KA1 TQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREA :::.::::::::. ::.:::::::::::::. ::::::.::.:: ...:::.:::::::: CCDS73 TQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREA 340 350 360 370 380 390 860 870 880 890 900 910 pF1KA1 NHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYL ::::::::::::::::::::.::::::::::::::::::..::.:: :::: :.:: :: CCDS73 NHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYL 400 410 420 430 440 450 920 930 940 950 960 970 pF1KA1 YGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQGTILQY .::: ::.::: ::.:::::::::::..:::::::::::::::::::.:::::::::::: CCDS73 HGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQY 460 470 480 490 500 510 980 990 1000 1010 1020 1030 pF1KA1 VKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCL ::::.::::::::::::::::::::::::::::::.::::::: ::.:::::::::::: CCDS73 VKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCL 520 530 540 550 560 570 1040 1050 1060 1070 1080 1090 pF1KA1 LIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAPLHLVPLIERLGT ::::.:: :::::::::::::::::::..::::::...:::::.:::::::::::::::: CCDS73 LIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGT 580 590 600 610 620 630 1100 1110 1120 1130 1140 1150 pF1KA1 PQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFH ::::::::::::::::::::::::::::::::::.:.::::::: :.::::::::::::: CCDS73 PQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFH 640 650 660 670 680 690 1160 1170 1180 1190 1200 1210 pF1KA1 RLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQR ::::::::::::::::.:::.::::::::.:::: ::::::::::: ..::::::::::. CCDS73 RLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQK 700 710 720 730 740 750 1220 1230 1240 1250 1260 1270 pF1KA1 QDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTVEHVRCFQPPIHQ .:::::::::::::::..::::.::::.:...::.::.:: . ... ::::::::::::: CCDS73 HDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQ 760 770 780 790 800 810 pF1KA1 SLATTC :::.. CCDS73 SLASS 820 >>CCDS73696.1 CYFIP1 gene_id:23191|Hs108|chr15 (1253 aa) initn: 7458 init1: 4101 opt: 4101 Z-score: 4972.7 bits: 932.3 E(32554): 0 Smith-Waterman score: 7412; 85.8% identity (94.9% similar) in 1278 aa overlap (1-1277:1-1253) 10 20 30 40 50 60 pF1KA1 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI :...:::::::::::::::::::::::::::::::..:: ::.::::::::::::::::: CCDS73 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: CCDS73 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS :::.::::::.::::::.::.:::::::::::::::::.::::::::::::::::::::: CCDS73 KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD ::::::::::::::::::::::::::::::::::::::.::: :.:::::: :::::::: CCDS73 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK :::.:::::::.::::::::::::::::::::::::.::::::::::::::::::::.:: CCDS73 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 QLQVVPLFGDMQIELARYIETSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI :::::::::::::::::::.::::::::::.::::.:. ::::::::::.:::.::.::: CCDS73 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI 310 320 330 340 350 360 370 380 390 400 410 pF1KA1 SELARYSNSEVVTGSG-LDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPT :::::::::::::::: ..::.: :::.::::::.::::::.::::::::::::::::: CCDS73 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA1 DKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTI ::. ::::: .:::::::::::::::::::.::::::::::::::::::::::.:::.:. CCDS73 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA1 YAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPK :::::::.:::::::::::..:::::. :::::::::.:::: :.:: ::: :::::::: CCDS73 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA1 GGFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSG .::::::::::::::::: ::::::::::::::::: CCDS73 SGFDIKVPRRAVGPSSTQ-------------------------LYMVRTMLESLIADKSG 550 560 570 600 610 620 630 640 650 pF1KA1 SKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRR :::::::::.:: .: :: ::..:::.:::.:.::.:::::::::::::::::::::::: CCDS73 SKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTMGRR 580 590 600 610 620 630 660 670 680 690 700 710 pF1KA1 IQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEV :::::::::::::::::::::: :::::::: ::::::::.::::.:.:::::::::::: CCDS73 IQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEV 640 650 660 670 680 690 720 730 740 750 760 770 pF1KA1 NLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHV ::::::::::::::::::::.::::.:::::.:.:::: :. : ::::::::::::::: CCDS73 NLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHV 700 710 720 730 740 750 780 790 800 810 820 830 pF1KA1 QLLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKH ::::::::::::::::.::::::::. ::.:::::::::::::. ::::::.::.:: .. CCDS73 QLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRY 760 770 780 790 800 810 840 850 860 870 880 890 pF1KA1 MTLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEP .:::.::::::::::::::::::::::::::::.::::::::::::::::::..::.:: CCDS73 LTLDGFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEF 820 830 840 850 860 870 900 910 920 930 940 950 pF1KA1 QRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLK :::: :.:: ::.::: ::.::: ::.:::::::::::..::::::::::::::::::: CCDS73 QRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLK 880 890 900 910 920 930 960 970 980 990 1000 1010 pF1KA1 IVKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQ .::::::::::::::::.::::::::::::::::::::::::::::::.::::::: :: CCDS73 VVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQ 940 950 960 970 980 990 1020 1030 1040 1050 1060 1070 pF1KA1 SLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYA .::::::::::::::::.:: :::::::::::::::::::..::::::...:::::.::: CCDS73 NLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYA 1000 1010 1020 1030 1040 1050 1080 1090 1100 1110 1120 1130 pF1KA1 PLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPT :::::::::::::::::::::::::::::::::::::::::::::::.:.::::::: :. CCDS73 PLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPS 1060 1070 1080 1090 1100 1110 1140 1150 1160 1170 1180 1190 pF1KA1 NGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFD :::::::::::::::::::::::::::::.:::.::::::::.:::: ::::::::::: CCDS73 NGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFA 1120 1130 1140 1150 1160 1170 1200 1210 1220 1230 1240 1250 pF1KA1 LFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSST ..::::::::::..:::::::::::::::..::::.::::.:...::.::.:: . ... CCDS73 VLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGEGTP 1180 1190 1200 1210 1220 1230 1260 1270 pF1KA1 VEHVRCFQPPIHQSLATTC ::::::::::::::::.. CCDS73 VEHVRCFQPPIHQSLASS 1240 1250 1278 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 20:41:08 2016 done: Wed Nov 2 20:41:09 2016 Total Scan time: 3.860 Total Display time: 0.240 Function used was FASTA [36.3.4 Apr, 2011]