Result of FASTA (omim) for
pF1KA1168
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1168, 1278 aa
1>>>pF1KA1168 1278 - 1278 aa - 1278 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5788+/-0.000443; mu= 21.1619+/- 0.028
mean_var=72.5389+/-14.252, 0's: 0 Z-trim(109.5): 32 B-trim: 0 in 0/51
Lambda= 0.150587
statistics sampled from 17618 (17641) to 17618 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.544), E-opt: 0.2 (0.207), width: 16
Scan time: 12.780
The best scores are: opt bits E(85289)
NP_001278651 (OMIM: 606323) cytoplasmic FMR1-inter (1278) 8589 1876.5 0
XP_016864831 (OMIM: 606323) PREDICTED: cytoplasmic (1182) 4691 1029.6 0
NP_001278650 (OMIM: 606323) cytoplasmic FMR1-inter (1227) 4691 1029.6 0
XP_016864830 (OMIM: 606323) PREDICTED: cytoplasmic (1253) 4691 1029.6 0
NP_055191 (OMIM: 606323) cytoplasmic FMR1-interact (1253) 4691 1029.6 0
XP_011532818 (OMIM: 606323) PREDICTED: cytoplasmic (1253) 4691 1029.6 0
NP_001032410 (OMIM: 606323) cytoplasmic FMR1-inter (1253) 4691 1029.6 0
NP_001028200 (OMIM: 606322) cytoplasmic FMR1-inter ( 822) 4101 901.3 0
NP_001311054 (OMIM: 606322) cytoplasmic FMR1-inter (1131) 4101 901.4 0
NP_001311055 (OMIM: 606322) cytoplasmic FMR1-inter (1219) 4101 901.4 0
NP_001311053 (OMIM: 606322) cytoplasmic FMR1-inter (1223) 4101 901.4 0
NP_001311049 (OMIM: 606322) cytoplasmic FMR1-inter (1253) 4101 901.4 0
NP_055423 (OMIM: 606322) cytoplasmic FMR1-interact (1253) 4101 901.4 0
NP_001274739 (OMIM: 606322) cytoplasmic FMR1-inter (1253) 4101 901.4 0
NP_001311052 (OMIM: 606322) cytoplasmic FMR1-inter (1253) 4101 901.4 0
NP_001311048 (OMIM: 606322) cytoplasmic FMR1-inter (1287) 4101 901.4 0
XP_016877513 (OMIM: 606322) PREDICTED: cytoplasmic (1386) 4101 901.4 0
XP_011542176 (OMIM: 606322) PREDICTED: cytoplasmic (1386) 4101 901.4 0
XP_011542175 (OMIM: 606322) PREDICTED: cytoplasmic (1386) 4101 901.4 0
XP_016877512 (OMIM: 606322) PREDICTED: cytoplasmic (1420) 4101 901.5 0
NP_001311051 (OMIM: 606322) cytoplasmic FMR1-inter ( 693) 4088 898.5 0
XP_011542178 (OMIM: 606322) PREDICTED: cytoplasmic (1285) 3906 859.1 0
>>NP_001278651 (OMIM: 606323) cytoplasmic FMR1-interacti (1278 aa)
initn: 8589 init1: 8589 opt: 8589 Z-score: 10075.1 bits: 1876.5 E(85289): 0
Smith-Waterman score: 8589; 99.9% identity (100.0% similar) in 1278 aa overlap (1-1278:1-1278)
10 20 30 40 50 60
pF1KA1 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 QLQVVPLFGDMQIELARYIETSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
NP_001 QLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 SELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 KFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 GFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSGS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 KKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 QFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 LCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHM
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 TLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 RDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKI
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 VKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 LREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAP
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 LHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA1 GVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA1 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTV
1210 1220 1230 1240 1250 1260
1270
pF1KA1 EHVRCFQPPIHQSLATTC
::::::::::::::::::
NP_001 EHVRCFQPPIHQSLATTC
1270
>>XP_016864831 (OMIM: 606323) PREDICTED: cytoplasmic FMR (1182 aa)
initn: 7911 init1: 4690 opt: 4691 Z-score: 5498.9 bits: 1029.6 E(85289): 0
Smith-Waterman score: 7865; 97.8% identity (97.9% similar) in 1207 aa overlap (72-1278:1-1182)
50 60 70 80 90 100
pF1KA1 FDTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQ
::::::::::::::::::::::::::::::
XP_016 MLEEGHEYAVMLYTWRSCSRAIPQVKCNEQ
10 20 30
110 120 130 140 150 160
pF1KA1 PNRVEIYEKTVEVLEPEVTKLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNRVEIYEKTVEVLEPEVTKLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTL
40 50 60 70 80 90
170 180 190 200 210 220
pF1KA1 GKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRIT
100 110 120 130 140 150
230 240 250 260 270 280
pF1KA1 QCLHQQLEVIPGYEELLADIVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QCLHQQLEVIPGYEELLADIVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNI
160 170 180 190 200 210
290 300 310 320 330 340
pF1KA1 YKLDAKKRINLSKIDKFFKQLQVVPLFGDMQIELARYIETSAHYEENKSKWTCTQSSISP
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_016 YKLDAKKRINLSKIDKFFKQLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISP
220 230 240 250 260 270
350 360 370 380 390 400
pF1KA1 QYNICEQMVQIRDDHIRFISELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYNICEQMVQIRDDHIRFISELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLS
280 290 300 310 320 330
410 420 430 440 450 460
pF1KA1 KWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQ
340 350 360 370 380 390
470 480 490 500 510 520
pF1KA1 VLMGRMESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLMGRMESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWE
400 410 420 430 440 450
530 540 550 560 570 580
pF1KA1 GGREPPNDPCLRGEKDPKGGFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRS
::::::::::::::::::::::::::::::::::::
XP_016 GGREPPNDPCLRGEKDPKGGFDIKVPRRAVGPSSTQ------------------------
460 470 480
590 600 610 620 630 640
pF1KA1 LLYMVRTMLESLIADKSGSKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCD
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 -LYMVRTMLESLIADKSGSKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCD
490 500 510 520 530 540
650 660 670 680 690 700
pF1KA1 LSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYY
550 560 570 580 590 600
710 720 730 740 750 760
pF1KA1 ALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVI
610 620 630 640 650 660
770 780 790 800 810 820
pF1KA1 IPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVE
670 680 690 700 710 720
830 840 850 860 870 880
pF1KA1 LEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCY
730 740 750 760 770 780
890 900 910 920 930 940
pF1KA1 NGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTI
790 800 810 820 830 840
950 960 970 980 990 1000
pF1KA1 CRLLGYQGIAVVMEELLKIVKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CRLLGYQGIAVVMEELLKIVKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFH
850 860 870 880 890 900
1010 1020 1030 1040 1050 1060
pF1KA1 HQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYI
910 920 930 940 950 960
1070 1080 1090 1100 1110 1120
pF1KA1 KEGERLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEGERLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVIL
970 980 990 1000 1010 1020
1130 1140 1150 1160 1170 1180
pF1KA1 TRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGL
1030 1040 1050 1060 1070 1080
1190 1200 1210 1220 1230 1240
pF1KA1 NWAGCSIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NWAGCSIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNE
1090 1100 1110 1120 1130 1140
1250 1260 1270
pF1KA1 VFAILNKYMKSVETDSSTVEHVRCFQPPIHQSLATTC
:::::::::::::::::::::::::::::::::::::
XP_016 VFAILNKYMKSVETDSSTVEHVRCFQPPIHQSLATTC
1150 1160 1170 1180
>>NP_001278650 (OMIM: 606323) cytoplasmic FMR1-interacti (1227 aa)
initn: 7741 init1: 4690 opt: 4691 Z-score: 5498.7 bits: 1029.6 E(85289): 0
Smith-Waterman score: 8091; 95.9% identity (96.0% similar) in 1278 aa overlap (1-1278:1-1227)
10 20 30 40 50 60
pF1KA1 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT
::::::::: :::::::::::::::::::::::::
NP_001 EQATVHSSM--------------------------VKCNEQPNRVEIYEKTVEVLEPEVT
70 80 90
130 140 150 160 170 180
pF1KA1 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS
100 110 120 130 140 150
190 200 210 220 230 240
pF1KA1 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD
160 170 180 190 200 210
250 260 270 280 290 300
pF1KA1 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK
220 230 240 250 260 270
310 320 330 340 350 360
pF1KA1 QLQVVPLFGDMQIELARYIETSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
NP_001 QLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI
280 290 300 310 320 330
370 380 390 400 410 420
pF1KA1 SELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTD
340 350 360 370 380 390
430 440 450 460 470 480
pF1KA1 KFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY
400 410 420 430 440 450
490 500 510 520 530 540
pF1KA1 AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKG
460 470 480 490 500 510
550 560 570 580 590 600
pF1KA1 GFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSGS
::::::::::::::::: ::::::::::::::::::
NP_001 GFDIKVPRRAVGPSSTQ-------------------------LYMVRTMLESLIADKSGS
520 530 540
610 620 630 640 650 660
pF1KA1 KKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRI
550 560 570 580 590 600
670 680 690 700 710 720
pF1KA1 QFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVN
610 620 630 640 650 660
730 740 750 760 770 780
pF1KA1 LCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQ
670 680 690 700 710 720
790 800 810 820 830 840
pF1KA1 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHM
730 740 750 760 770 780
850 860 870 880 890 900
pF1KA1 TLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQ
790 800 810 820 830 840
910 920 930 940 950 960
pF1KA1 RDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKI
850 860 870 880 890 900
970 980 990 1000 1010 1020
pF1KA1 VKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQS
910 920 930 940 950 960
1030 1040 1050 1060 1070 1080
pF1KA1 LREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAP
970 980 990 1000 1010 1020
1090 1100 1110 1120 1130 1140
pF1KA1 LHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTN
1030 1040 1050 1060 1070 1080
1150 1160 1170 1180 1190 1200
pF1KA1 GVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL
1090 1100 1110 1120 1130 1140
1210 1220 1230 1240 1250 1260
pF1KA1 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTV
1150 1160 1170 1180 1190 1200
1270
pF1KA1 EHVRCFQPPIHQSLATTC
::::::::::::::::::
NP_001 EHVRCFQPPIHQSLATTC
1210 1220
>>XP_016864830 (OMIM: 606323) PREDICTED: cytoplasmic FMR (1253 aa)
initn: 8382 init1: 4690 opt: 4691 Z-score: 5498.5 bits: 1029.6 E(85289): 0
Smith-Waterman score: 8336; 98.0% identity (98.0% similar) in 1278 aa overlap (1-1278:1-1253)
10 20 30 40 50 60
pF1KA1 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 QLQVVPLFGDMQIELARYIETSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
XP_016 QLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 SELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 KFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 GFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSGS
::::::::::::::::: ::::::::::::::::::
XP_016 GFDIKVPRRAVGPSSTQ-------------------------LYMVRTMLESLIADKSGS
550 560 570
610 620 630 640 650 660
pF1KA1 KKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRI
580 590 600 610 620 630
670 680 690 700 710 720
pF1KA1 QFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVN
640 650 660 670 680 690
730 740 750 760 770 780
pF1KA1 LCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQ
700 710 720 730 740 750
790 800 810 820 830 840
pF1KA1 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHM
760 770 780 790 800 810
850 860 870 880 890 900
pF1KA1 TLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQ
820 830 840 850 860 870
910 920 930 940 950 960
pF1KA1 RDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKI
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KA1 VKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQS
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KA1 LREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAP
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KA1 LHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTN
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190 1200
pF1KA1 GVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL
1120 1130 1140 1150 1160 1170
1210 1220 1230 1240 1250 1260
pF1KA1 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTV
1180 1190 1200 1210 1220 1230
1270
pF1KA1 EHVRCFQPPIHQSLATTC
::::::::::::::::::
XP_016 EHVRCFQPPIHQSLATTC
1240 1250
>>NP_055191 (OMIM: 606323) cytoplasmic FMR1-interacting (1253 aa)
initn: 8382 init1: 4690 opt: 4691 Z-score: 5498.5 bits: 1029.6 E(85289): 0
Smith-Waterman score: 8336; 98.0% identity (98.0% similar) in 1278 aa overlap (1-1278:1-1253)
10 20 30 40 50 60
pF1KA1 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 QLQVVPLFGDMQIELARYIETSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
NP_055 QLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 SELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 KFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 GFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSGS
::::::::::::::::: ::::::::::::::::::
NP_055 GFDIKVPRRAVGPSSTQ-------------------------LYMVRTMLESLIADKSGS
550 560 570
610 620 630 640 650 660
pF1KA1 KKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRI
580 590 600 610 620 630
670 680 690 700 710 720
pF1KA1 QFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVN
640 650 660 670 680 690
730 740 750 760 770 780
pF1KA1 LCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQ
700 710 720 730 740 750
790 800 810 820 830 840
pF1KA1 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHM
760 770 780 790 800 810
850 860 870 880 890 900
pF1KA1 TLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQ
820 830 840 850 860 870
910 920 930 940 950 960
pF1KA1 RDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKI
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KA1 VKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQS
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KA1 LREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAP
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KA1 LHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTN
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190 1200
pF1KA1 GVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL
1120 1130 1140 1150 1160 1170
1210 1220 1230 1240 1250 1260
pF1KA1 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTV
1180 1190 1200 1210 1220 1230
1270
pF1KA1 EHVRCFQPPIHQSLATTC
::::::::::::::::::
NP_055 EHVRCFQPPIHQSLATTC
1240 1250
>>XP_011532818 (OMIM: 606323) PREDICTED: cytoplasmic FMR (1253 aa)
initn: 8382 init1: 4690 opt: 4691 Z-score: 5498.5 bits: 1029.6 E(85289): 0
Smith-Waterman score: 8336; 98.0% identity (98.0% similar) in 1278 aa overlap (1-1278:1-1253)
10 20 30 40 50 60
pF1KA1 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 QLQVVPLFGDMQIELARYIETSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
XP_011 QLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 SELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 KFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 GFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSGS
::::::::::::::::: ::::::::::::::::::
XP_011 GFDIKVPRRAVGPSSTQ-------------------------LYMVRTMLESLIADKSGS
550 560 570
610 620 630 640 650 660
pF1KA1 KKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRI
580 590 600 610 620 630
670 680 690 700 710 720
pF1KA1 QFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVN
640 650 660 670 680 690
730 740 750 760 770 780
pF1KA1 LCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQ
700 710 720 730 740 750
790 800 810 820 830 840
pF1KA1 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHM
760 770 780 790 800 810
850 860 870 880 890 900
pF1KA1 TLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQ
820 830 840 850 860 870
910 920 930 940 950 960
pF1KA1 RDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKI
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KA1 VKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQS
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KA1 LREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAP
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KA1 LHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTN
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190 1200
pF1KA1 GVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL
1120 1130 1140 1150 1160 1170
1210 1220 1230 1240 1250 1260
pF1KA1 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTV
1180 1190 1200 1210 1220 1230
1270
pF1KA1 EHVRCFQPPIHQSLATTC
::::::::::::::::::
XP_011 EHVRCFQPPIHQSLATTC
1240 1250
>>NP_001032410 (OMIM: 606323) cytoplasmic FMR1-interacti (1253 aa)
initn: 8382 init1: 4690 opt: 4691 Z-score: 5498.5 bits: 1029.6 E(85289): 0
Smith-Waterman score: 8336; 98.0% identity (98.0% similar) in 1278 aa overlap (1-1278:1-1253)
10 20 30 40 50 60
pF1KA1 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 QLQVVPLFGDMQIELARYIETSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
NP_001 QLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 SELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 KFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 GFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSGS
::::::::::::::::: ::::::::::::::::::
NP_001 GFDIKVPRRAVGPSSTQ-------------------------LYMVRTMLESLIADKSGS
550 560 570
610 620 630 640 650 660
pF1KA1 KKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRI
580 590 600 610 620 630
670 680 690 700 710 720
pF1KA1 QFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVN
640 650 660 670 680 690
730 740 750 760 770 780
pF1KA1 LCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQ
700 710 720 730 740 750
790 800 810 820 830 840
pF1KA1 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHM
760 770 780 790 800 810
850 860 870 880 890 900
pF1KA1 TLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQ
820 830 840 850 860 870
910 920 930 940 950 960
pF1KA1 RDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKI
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KA1 VKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQS
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KA1 LREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAP
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KA1 LHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTN
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190 1200
pF1KA1 GVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL
1120 1130 1140 1150 1160 1170
1210 1220 1230 1240 1250 1260
pF1KA1 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTV
1180 1190 1200 1210 1220 1230
1270
pF1KA1 EHVRCFQPPIHQSLATTC
::::::::::::::::::
NP_001 EHVRCFQPPIHQSLATTC
1240 1250
>>NP_001028200 (OMIM: 606322) cytoplasmic FMR1-interacti (822 aa)
initn: 4131 init1: 4101 opt: 4101 Z-score: 4808.6 bits: 901.3 E(85289): 0
Smith-Waterman score: 4101; 85.8% identity (96.1% similar) in 695 aa overlap (583-1277:128-822)
560 570 580 590 600 610
pF1KA1 PSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSGSKKTLRSSLDGPI
::::::::::::::::::::::::::.::
NP_001 QSFSHGLFEFGITNVPCIFSPPQMFPWIIQLYMVRTMLESLIADKSGSKKTLRSSLEGPT
100 110 120 130 140 150
620 630 640 650 660 670
pF1KA1 VLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWIL
.: :: ::..:::.:::.:.::.:::::::::::::::::::::::::::::::::::::
NP_001 ILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWIL
160 170 180 190 200 210
680 690 700 710 720 730
pF1KA1 TDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKLAD
::::::::: :::::::: ::::::::.::::.:.:::::::::::::::::::::::::
NP_001 TDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLAD
220 230 240 250 260 270
740 750 760 770 780 790
pF1KA1 QIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQLLGRSIDLNRLI
:::::::.::::.:::::.:.:::: :. : ::::::::::::::::::::::::::::
NP_001 QIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLI
280 290 300 310 320 330
800 810 820 830 840 850
pF1KA1 TQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREA
:::.::::::::. ::.:::::::::::::. ::::::.::.:: ...:::.::::::::
NP_001 TQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREA
340 350 360 370 380 390
860 870 880 890 900 910
pF1KA1 NHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYL
::::::::::::::::::::.::::::::::::::::::..::.:: :::: :.:: ::
NP_001 NHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYL
400 410 420 430 440 450
920 930 940 950 960 970
pF1KA1 YGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQGTILQY
.::: ::.::: ::.:::::::::::..:::::::::::::::::::.::::::::::::
NP_001 HGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQY
460 470 480 490 500 510
980 990 1000 1010 1020 1030
pF1KA1 VKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCL
::::.::::::::::::::::::::::::::::::.::::::: ::.::::::::::::
NP_001 VKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCL
520 530 540 550 560 570
1040 1050 1060 1070 1080 1090
pF1KA1 LIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAPLHLVPLIERLGT
::::.:: :::::::::::::::::::..::::::...:::::.::::::::::::::::
NP_001 LIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGT
580 590 600 610 620 630
1100 1110 1120 1130 1140 1150
pF1KA1 PQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFH
::::::::::::::::::::::::::::::::::.:.::::::: :.:::::::::::::
NP_001 PQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFH
640 650 660 670 680 690
1160 1170 1180 1190 1200 1210
pF1KA1 RLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQR
::::::::::::::::.:::.::::::::.:::: ::::::::::: ..::::::::::.
NP_001 RLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQK
700 710 720 730 740 750
1220 1230 1240 1250 1260 1270
pF1KA1 QDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTVEHVRCFQPPIHQ
.:::::::::::::::..::::.::::.:...::.::.:: . ... :::::::::::::
NP_001 HDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQ
760 770 780 790 800 810
pF1KA1 SLATTC
:::..
NP_001 SLASS
820
>>NP_001311054 (OMIM: 606322) cytoplasmic FMR1-interacti (1131 aa)
initn: 6691 init1: 4101 opt: 4101 Z-score: 4806.5 bits: 901.4 E(85289): 0
Smith-Waterman score: 6645; 85.0% identity (94.5% similar) in 1156 aa overlap (123-1277:1-1131)
100 110 120 130 140 150
pF1KA1 IPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMKFMYFQRKAIERFCSEVKRLCHAERRKDF
:.::::::.::::::.::.:::::::::::
NP_001 MNFMYFQRNAIERFCGEVRRLCHAERRKDF
10 20 30
160 170 180 190 200 210
pF1KA1 VSEAYLLTLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSM
::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSM
40 50 60 70 80 90
220 230 240 250 260 270
pF1KA1 FLANHNRITQCLHQQLEVIPGYEELLADIVNICVDYYENKMYLTPSEKHMLLKVMGFGLY
::::::.::: :.:::::: :::::::::::.:::::::.::::::::::::::::::::
NP_001 FLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLY
100 110 120 130 140 150
280 290 300 310 320 330
pF1KA1 LMDGNVSNIYKLDAKKRINLSKIDKFFKQLQVVPLFGDMQIELARYIETSAHYEENKSKW
::::.::::::::::::::::::::.:::::::::::::::::::::.::::::::::.:
NP_001 LMDGSVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRW
160 170 180 190 200 210
340 350 360 370 380 390
pF1KA1 TCTQSSISPQYNICEQMVQIRDDHIRFISELARYSNSEVVTGSG-LDSQKSDEEYRELFD
:::.:. ::::::::::.:::.::.::::::::::::::::::: ..::.: :::.:::
NP_001 TCTSSGSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKLFD
220 230 240 250 260 270
400 410 420 430 440 450
pF1KA1 LALRGLQLLSKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFV
:::.::::::.:::::::::::::::::::. ::::: .:::::::::::::::::::.:
NP_001 LALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFALV
280 290 300 310 320 330
460 470 480 490 500 510
pF1KA1 EVIAMIKGLQVLMGRMESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLISVLQ
:::::::::::::::::::::.:::.:.:::::::.:::::::::::..:::::. ::::
NP_001 EVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQ
340 350 360 370 380 390
520 530 540 550 560 570
pF1KA1 AIRKTICDWEGGREPPNDPCLRGEKDPKGGFDIKVPRRAVGPSSTQACQWSPRALFHPTG
:::::.:::: :.:: ::: ::::::::.:::::::::::::::::
NP_001 AIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQ--------------
400 410 420 430
580 590 600 610 620 630
pF1KA1 GTQGRRGCRSLLYMVRTMLESLIADKSGSKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLN
::::::::::::::::::::::::::.:: .: :: ::..:::.:::.:
NP_001 -----------LYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLIN
440 450 460 470 480
640 650 660 670 680 690
pF1KA1 ISEALQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYP
.::.:::::::::::::::::::::::::::::::::::::::::::::: ::::::::
NP_001 FSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYS
490 500 510 520 530 540
700 710 720 730 740 750
pF1KA1 LDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRF
::::::::.::::.:.::::::::::::::::::::::::::::::::.::::.:::::.
NP_001 LDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRL
550 560 570 580 590 600
760 770 780 790 800 810
pF1KA1 RAECKNYGVIIPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLDQAISRF
:.:::: :. : :::::::::::::::::::::::::::::::.::::::::. ::.::
NP_001 RSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRF
610 620 630 640 650 660
820 830 840 850 860 870
pF1KA1 ESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVSAPYGRITLHVFWEL
:::::::::::. ::::::.::.:: ...:::.:::::::::::::::::::::::::::
NP_001 ESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRITLHVFWEL
670 680 690 700 710 720
880 890 900 910 920 930
pF1KA1 NFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRN
:.::::::::::::::::::..::.:: :::: :.:: ::.::: ::.::: ::.::::
NP_001 NYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRN
730 740 750 760 770 780
940 950 960 970 980 990
pF1KA1 FVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQGTILQYVKTLIEVMPKICRLPRHEY
:::::::..:::::::::::::::::::.::::::::::::::::.::::::::::::::
NP_001 FVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEY
790 800 810 820 830 840
1000 1010 1020 1030 1040 1050
pF1KA1 GSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLLHAAP
::::::::::::::::.::::::: ::.::::::::::::::::.:: :::::::::::
NP_001 GSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAAP
850 860 870 880 890 900
1060 1070 1080 1090 1100 1110
pF1KA1 FQNILPRVYIKEGERLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLC
::::::::..::::::...:::::.:::::::::::::::::::::::::::::::::::
NP_001 FQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLC
910 920 930 940 950 960
1120 1130 1140 1150 1160 1170
pF1KA1 CGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEF
:::::::::::::::.:.::::::: :.:::::::::::::::::::::::::::::.::
NP_001 CGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEF
970 980 990 1000 1010 1020
1180 1190 1200 1210 1220 1230
pF1KA1 TAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMADR
:.::::::::.:::: ::::::::::: ..::::::::::..:::::::::::::::..:
NP_001 TVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVER
1030 1040 1050 1060 1070 1080
1240 1250 1260 1270
pF1KA1 IRKYQILNNEVFAILNKYMKSVETDSSTVEHVRCFQPPIHQSLATTC
:::.::::.:...::.::.:: . ... ::::::::::::::::..
NP_001 IRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS
1090 1100 1110 1120 1130
>>NP_001311055 (OMIM: 606322) cytoplasmic FMR1-interacti (1219 aa)
initn: 6653 init1: 4101 opt: 4101 Z-score: 4806.0 bits: 901.4 E(85289): 0
Smith-Waterman score: 7116; 83.3% identity (92.3% similar) in 1278 aa overlap (1-1277:1-1219)
10 20 30 40 50 60
pF1KA1 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI
:...:::::::::::::::::::::::::::::::..:: ::.:::::::::::::::::
NP_001 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT
::::::::::::::::.::::::::::::::::::
NP_001 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQ-------------------------
70 80 90
130 140 150 160 170 180
pF1KA1 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS
:.::::::.::.:::::::::::::::::.:::::::::::::::::::::
NP_001 ---------RNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS
100 110 120 130 140
190 200 210 220 230 240
pF1KA1 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD
::::::::::::::::::::::::::::::::::::::.::: :.:::::: ::::::::
NP_001 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD
150 160 170 180 190 200
250 260 270 280 290 300
pF1KA1 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK
:::.:::::::.::::::::::::::::::::::::.::::::::::::::::::::.::
NP_001 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK
210 220 230 240 250 260
310 320 330 340 350 360
pF1KA1 QLQVVPLFGDMQIELARYIETSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI
:::::::::::::::::::.::::::::::.::::.:. ::::::::::.:::.::.:::
NP_001 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI
270 280 290 300 310 320
370 380 390 400 410
pF1KA1 SELARYSNSEVVTGSG-LDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPT
:::::::::::::::: ..::.: :::.::::::.::::::.:::::::::::::::::
NP_001 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT
330 340 350 360 370 380
420 430 440 450 460 470
pF1KA1 DKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTI
::. ::::: .:::::::::::::::::::.::::::::::::::::::::::.:::.:.
NP_001 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV
390 400 410 420 430 440
480 490 500 510 520 530
pF1KA1 YAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPK
:::::::.:::::::::::..:::::. :::::::::.:::: :.:: ::: ::::::::
NP_001 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK
450 460 470 480 490 500
540 550 560 570 580 590
pF1KA1 GGFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSG
.::::::::::::::::: :::::::::::::::::
NP_001 SGFDIKVPRRAVGPSSTQ-------------------------LYMVRTMLESLIADKSG
510 520 530 540
600 610 620 630 640 650
pF1KA1 SKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRR
:::::::::.:: .: :: ::..:::.:::.:.::.::::::::::::::::::::::::
NP_001 SKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTMGRR
550 560 570 580 590 600
660 670 680 690 700 710
pF1KA1 IQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEV
:::::::::::::::::::::: :::::::: ::::::::.::::.:.::::::::::::
NP_001 IQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEV
610 620 630 640 650 660
720 730 740 750 760 770
pF1KA1 NLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHV
::::::::::::::::::::.::::.:::::.:.:::: :. : :::::::::::::::
NP_001 NLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHV
670 680 690 700 710 720
780 790 800 810 820 830
pF1KA1 QLLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKH
::::::::::::::::.::::::::. ::.:::::::::::::. ::::::.::.:: ..
NP_001 QLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRY
730 740 750 760 770 780
840 850 860 870 880 890
pF1KA1 MTLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEP
.:::.::::::::::::::::::::::::::::.::::::::::::::::::..::.::
NP_001 LTLDGFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEF
790 800 810 820 830 840
900 910 920 930 940 950
pF1KA1 QRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLK
:::: :.:: ::.::: ::.::: ::.:::::::::::..:::::::::::::::::::
NP_001 QRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLK
850 860 870 880 890 900
960 970 980 990 1000 1010
pF1KA1 IVKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQ
.::::::::::::::::.::::::::::::::::::::::::::::::.::::::: ::
NP_001 VVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQ
910 920 930 940 950 960
1020 1030 1040 1050 1060 1070
pF1KA1 SLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYA
.::::::::::::::::.:: :::::::::::::::::::..::::::...:::::.:::
NP_001 NLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYA
970 980 990 1000 1010 1020
1080 1090 1100 1110 1120 1130
pF1KA1 PLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPT
:::::::::::::::::::::::::::::::::::::::::::::::.:.::::::: :.
NP_001 PLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPS
1030 1040 1050 1060 1070 1080
1140 1150 1160 1170 1180 1190
pF1KA1 NGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFD
:::::::::::::::::::::::::::::.:::.::::::::.:::: :::::::::::
NP_001 NGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFA
1090 1100 1110 1120 1130 1140
1200 1210 1220 1230 1240 1250
pF1KA1 LFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSST
..::::::::::..:::::::::::::::..::::.::::.:...::.::.:: . ...
NP_001 VLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGEGTP
1150 1160 1170 1180 1190 1200
1260 1270
pF1KA1 VEHVRCFQPPIHQSLATTC
::::::::::::::::..
NP_001 VEHVRCFQPPIHQSLASS
1210
1278 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 20:41:09 2016 done: Wed Nov 2 20:41:11 2016
Total Scan time: 12.780 Total Display time: 0.630
Function used was FASTA [36.3.4 Apr, 2011]