FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1254, 757 aa 1>>>pF1KA1254 757 - 757 aa - 757 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.6618+/-0.000541; mu= -5.1212+/- 0.033 mean_var=367.4664+/-74.278, 0's: 0 Z-trim(116.9): 21 B-trim: 26 in 1/55 Lambda= 0.066906 statistics sampled from 28460 (28480) to 28460 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.675), E-opt: 0.2 (0.334), width: 16 Scan time: 9.370 The best scores are: opt bits E(85289) NP_004739 (OMIM: 611326) cell cycle progression pr ( 757) 4961 494.1 9.1e-139 NP_065790 (OMIM: 611326) cell cycle progression pr ( 757) 4961 494.1 9.1e-139 NP_001191379 (OMIM: 611326) cell cycle progression ( 807) 4869 485.2 4.5e-136 NP_001191380 (OMIM: 611326) cell cycle progression ( 424) 1996 207.6 8.5e-53 >>NP_004739 (OMIM: 611326) cell cycle progression protei (757 aa) initn: 4961 init1: 4961 opt: 4961 Z-score: 2612.3 bits: 494.1 E(85289): 9.1e-139 Smith-Waterman score: 4961; 99.9% identity (100.0% similar) in 757 aa overlap (1-757:1-757) 10 20 30 40 50 60 pF1KA1 MSENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MSENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGES 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 EVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRRRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRRRA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 RKKTVSASESEDRLVGEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: NP_004 RKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 TNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 EKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 KKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 SKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 KNIFDEKGNKRFGATKEAAEKPRTVFSDYLHPQYKAPTENHHNRGPTMQNDGRKEKPVHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KNIFDEKGNKRFGATKEAAEKPRTVFSDYLHPQYKAPTENHHNRGPTMQNDGRKEKPVHF 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 KEFRKNTNSKKCSPGHDCRENSHSFRKACSGVFDCAQQESMSLFNTVVNPIRMDEFRQII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KEFRKNTNSKKCSPGHDCRENSHSFRKACSGVFDCAQQESMSLFNTVVNPIRMDEFRQII 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 QRYMLKELDTFCHWNELDQFINKFFLNGVFIHDQKLFTDFVNDVKDYLRNMKEYEVDNDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QRYMLKELDTFCHWNELDQFINKFFLNGVFIHDQKLFTDFVNDVKDYLRNMKEYEVDNDG 670 680 690 700 710 720 730 740 750 pF1KA1 VFEKLDEYIYRHFFGHTFSPPYGPRSVYIKPCHYSSL ::::::::::::::::::::::::::::::::::::: NP_004 VFEKLDEYIYRHFFGHTFSPPYGPRSVYIKPCHYSSL 730 740 750 >>NP_065790 (OMIM: 611326) cell cycle progression protei (757 aa) initn: 4961 init1: 4961 opt: 4961 Z-score: 2612.3 bits: 494.1 E(85289): 9.1e-139 Smith-Waterman score: 4961; 99.9% identity (100.0% similar) in 757 aa overlap (1-757:1-757) 10 20 30 40 50 60 pF1KA1 MSENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MSENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGES 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 EVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRRRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 EVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRRRA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 RKKTVSASESEDRLVGEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: NP_065 RKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 TNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 TNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 EKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 EKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 KKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 KKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 SKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 KNIFDEKGNKRFGATKEAAEKPRTVFSDYLHPQYKAPTENHHNRGPTMQNDGRKEKPVHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 KNIFDEKGNKRFGATKEAAEKPRTVFSDYLHPQYKAPTENHHNRGPTMQNDGRKEKPVHF 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 KEFRKNTNSKKCSPGHDCRENSHSFRKACSGVFDCAQQESMSLFNTVVNPIRMDEFRQII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 KEFRKNTNSKKCSPGHDCRENSHSFRKACSGVFDCAQQESMSLFNTVVNPIRMDEFRQII 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 QRYMLKELDTFCHWNELDQFINKFFLNGVFIHDQKLFTDFVNDVKDYLRNMKEYEVDNDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 QRYMLKELDTFCHWNELDQFINKFFLNGVFIHDQKLFTDFVNDVKDYLRNMKEYEVDNDG 670 680 690 700 710 720 730 740 750 pF1KA1 VFEKLDEYIYRHFFGHTFSPPYGPRSVYIKPCHYSSL ::::::::::::::::::::::::::::::::::::: NP_065 VFEKLDEYIYRHFFGHTFSPPYGPRSVYIKPCHYSSL 730 740 750 >>NP_001191379 (OMIM: 611326) cell cycle progression pro (807 aa) initn: 4869 init1: 4869 opt: 4869 Z-score: 2564.0 bits: 485.2 E(85289): 4.5e-136 Smith-Waterman score: 4869; 99.9% identity (100.0% similar) in 744 aa overlap (1-744:1-744) 10 20 30 40 50 60 pF1KA1 MSENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGES 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 EVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRRRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRRRA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 RKKTVSASESEDRLVGEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: NP_001 RKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 TNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 EKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 KKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 SKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 KNIFDEKGNKRFGATKEAAEKPRTVFSDYLHPQYKAPTENHHNRGPTMQNDGRKEKPVHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KNIFDEKGNKRFGATKEAAEKPRTVFSDYLHPQYKAPTENHHNRGPTMQNDGRKEKPVHF 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 KEFRKNTNSKKCSPGHDCRENSHSFRKACSGVFDCAQQESMSLFNTVVNPIRMDEFRQII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEFRKNTNSKKCSPGHDCRENSHSFRKACSGVFDCAQQESMSLFNTVVNPIRMDEFRQII 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 QRYMLKELDTFCHWNELDQFINKFFLNGVFIHDQKLFTDFVNDVKDYLRNMKEYEVDNDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRYMLKELDTFCHWNELDQFINKFFLNGVFIHDQKLFTDFVNDVKDYLRNMKEYEVDNDG 670 680 690 700 710 720 730 740 750 pF1KA1 VFEKLDEYIYRHFFGHTFSPPYGPRSVYIKPCHYSSL :::::::::::::::::::::::: NP_001 VFEKLDEYIYRHFFGHTFSPPYGPSRPDKKQRMVNIENSRHRKQEQKHLQPQPYKREGKW 730 740 750 760 770 780 >>NP_001191380 (OMIM: 611326) cell cycle progression pro (424 aa) initn: 1996 init1: 1996 opt: 1996 Z-score: 1068.8 bits: 207.6 E(85289): 8.5e-53 Smith-Waterman score: 1996; 99.7% identity (100.0% similar) in 311 aa overlap (1-311:1-311) 10 20 30 40 50 60 pF1KA1 MSENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGES 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 EVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRRRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRRRA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 RKKTVSASESEDRLVGEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: NP_001 RKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 TNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEE ::::::::::: NP_001 TNLATENQYLRKLFTDFVNDVKDYLRNMKEYEVDNDGVFEKLDEYIYRHFFGHTFSPPYG 310 320 330 340 350 360 >-- initn: 355 init1: 355 opt: 355 Z-score: 212.8 bits: 49.2 E(85289): 4.1e-05 Smith-Waterman score: 355; 100.0% identity (100.0% similar) in 50 aa overlap (695-744:312-361) 670 680 690 700 710 720 pF1KA1 LKELDTFCHWNELDQFINKFFLNGVFIHDQKLFTDFVNDVKDYLRNMKEYEVDNDGVFEK :::::::::::::::::::::::::::::: NP_001 LARCWTLTEAEKMSFETQKTNLATENQYLRKLFTDFVNDVKDYLRNMKEYEVDNDGVFEK 290 300 310 320 330 340 730 740 750 pF1KA1 LDEYIYRHFFGHTFSPPYGPRSVYIKPCHYSSL :::::::::::::::::::: NP_001 LDEYIYRHFFGHTFSPPYGPSRPDKKQRMVNIENSRHRKQEQKHLQPQPYKREGKWHKYG 350 360 370 380 390 400 757 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 20:51:19 2016 done: Wed Nov 2 20:51:21 2016 Total Scan time: 9.370 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]