FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1255, 1211 aa 1>>>pF1KA1255 1211 - 1211 aa - 1211 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.2123+/-0.000817; mu= 8.9514+/- 0.050 mean_var=384.8847+/-83.119, 0's: 0 Z-trim(111.6): 473 B-trim: 534 in 1/48 Lambda= 0.065375 statistics sampled from 19700 (20279) to 19700 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.571), E-opt: 0.2 (0.238), width: 16 Scan time: 16.070 The best scores are: opt bits E(85289) NP_001244928 (OMIM: 607927) rabankyrin-5 isoform 3 (1211) 7984 770.1 0 XP_011522228 (OMIM: 607927) PREDICTED: rabankyrin- (1212) 7972 768.9 0 XP_016880222 (OMIM: 607927) PREDICTED: rabankyrin- (1273) 7654 739.0 4.6e-212 NP_001316992 (OMIM: 607927) rabankyrin-5 isoform 4 (1169) 7653 738.8 4.7e-212 NP_057460 (OMIM: 607927) rabankyrin-5 isoform 1 [H (1170) 7641 737.7 1e-211 XP_011522230 (OMIM: 607927) PREDICTED: rabankyrin- (1157) 7586 732.5 3.8e-210 XP_011522235 (OMIM: 607927) PREDICTED: rabankyrin- ( 708) 4530 443.9 1.7e-123 XP_011531845 (OMIM: 611122) PREDICTED: serine/thre (1019) 509 64.9 3e-09 NP_001182027 (OMIM: 611122) serine/threonine-prote ( 899) 453 59.6 1.1e-07 XP_016861516 (OMIM: 611122) PREDICTED: serine/thre ( 899) 453 59.6 1.1e-07 NP_001182028 (OMIM: 611122) serine/threonine-prote ( 899) 453 59.6 1.1e-07 XP_016861515 (OMIM: 611122) PREDICTED: serine/thre ( 899) 453 59.6 1.1e-07 XP_016863599 (OMIM: 106410,600919) PREDICTED: anky (1763) 424 57.3 1e-06 XP_016863592 (OMIM: 106410,600919) PREDICTED: anky (1816) 424 57.3 1.1e-06 XP_016863593 (OMIM: 106410,600919) PREDICTED: anky (1818) 424 57.3 1.1e-06 XP_016863590 (OMIM: 106410,600919) PREDICTED: anky (1839) 424 57.3 1.1e-06 XP_016863588 (OMIM: 106410,600919) PREDICTED: anky (1850) 424 57.3 1.1e-06 XP_016863587 (OMIM: 106410,600919) PREDICTED: anky (1851) 424 57.3 1.1e-06 XP_016863585 (OMIM: 106410,600919) PREDICTED: anky (1862) 424 57.3 1.1e-06 NP_001120965 (OMIM: 106410,600919) ankyrin-2 isofo (1863) 424 57.3 1.1e-06 XP_016863583 (OMIM: 106410,600919) PREDICTED: anky (1871) 424 57.3 1.1e-06 NP_066187 (OMIM: 106410,600919) ankyrin-2 isoform (1872) 424 57.3 1.1e-06 XP_016863582 (OMIM: 106410,600919) PREDICTED: anky (1881) 424 57.3 1.1e-06 XP_016863581 (OMIM: 106410,600919) PREDICTED: anky (1882) 424 57.3 1.1e-06 XP_016863579 (OMIM: 106410,600919) PREDICTED: anky (1886) 424 57.3 1.1e-06 XP_016863578 (OMIM: 106410,600919) PREDICTED: anky (1887) 424 57.3 1.1e-06 XP_016863577 (OMIM: 106410,600919) PREDICTED: anky (1893) 424 57.3 1.1e-06 XP_016863576 (OMIM: 106410,600919) PREDICTED: anky (1898) 424 57.3 1.1e-06 XP_016863575 (OMIM: 106410,600919) PREDICTED: anky (1899) 424 57.3 1.1e-06 XP_016863574 (OMIM: 106410,600919) PREDICTED: anky (1902) 424 57.3 1.1e-06 XP_016863573 (OMIM: 106410,600919) PREDICTED: anky (1915) 424 57.3 1.1e-06 XP_016863572 (OMIM: 106410,600919) PREDICTED: anky (1917) 424 57.3 1.1e-06 XP_016863571 (OMIM: 106410,600919) PREDICTED: anky (1926) 424 57.3 1.1e-06 XP_016863570 (OMIM: 106410,600919) PREDICTED: anky (1931) 424 57.3 1.1e-06 XP_016863567 (OMIM: 106410,600919) PREDICTED: anky (2020) 424 57.4 1.1e-06 NP_001139 (OMIM: 106410,600919) ankyrin-2 isoform (3957) 424 57.8 1.6e-06 XP_005263002 (OMIM: 106410,600919) PREDICTED: anky (4072) 424 57.8 1.6e-06 XP_016863565 (OMIM: 106410,600919) PREDICTED: anky (4105) 424 57.9 1.6e-06 XP_016863564 (OMIM: 106410,600919) PREDICTED: anky (4115) 424 57.9 1.6e-06 XP_016863563 (OMIM: 106410,600919) PREDICTED: anky (4127) 424 57.9 1.6e-06 XP_016863562 (OMIM: 106410,600919) PREDICTED: anky (4136) 424 57.9 1.6e-06 XP_016863560 (OMIM: 106410,600919) PREDICTED: anky (4145) 424 57.9 1.6e-06 XP_016863559 (OMIM: 106410,600919) PREDICTED: anky (4163) 424 57.9 1.6e-06 XP_016863557 (OMIM: 106410,600919) PREDICTED: anky (4181) 424 57.9 1.6e-06 XP_016863556 (OMIM: 106410,600919) PREDICTED: anky (4183) 424 57.9 1.6e-06 XP_016863596 (OMIM: 106410,600919) PREDICTED: anky (1797) 413 56.3 2.1e-06 XP_016863595 (OMIM: 106410,600919) PREDICTED: anky (1806) 413 56.3 2.2e-06 XP_016863591 (OMIM: 106410,600919) PREDICTED: anky (1838) 413 56.3 2.2e-06 XP_016863589 (OMIM: 106410,600919) PREDICTED: anky (1846) 413 56.3 2.2e-06 XP_016863586 (OMIM: 106410,600919) PREDICTED: anky (1858) 413 56.3 2.2e-06 >>NP_001244928 (OMIM: 607927) rabankyrin-5 isoform 3 [Ho (1211 aa) initn: 7984 init1: 7984 opt: 7984 Z-score: 4096.6 bits: 770.1 E(85289): 0 Smith-Waterman score: 7984; 100.0% identity (100.0% similar) in 1211 aa overlap (1-1211:1-1211) 10 20 30 40 50 60 pF1KA1 MPTPRDCGRLRSRAGRSRAGAACSRGAPRAAREALDCRRCRDAGGKEVAKLEKHLMLLRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPTPRDCGRLRSRAGRSRAGAACSRGAPRAAREALDCRRCRDAGGKEVAKLEKHLMLLRQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 EYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 ISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTEL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 MKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 KEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 ALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 TLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 NEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 FAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 CRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 VSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 MSDGQTLLHMAIQRQDSKSALFLLEHQADINVRTQDGETALQLAIRNQLPLVVDAICTRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSDGQTLLHMAIQRQDSKSALFLLEHQADINVRTQDGETALQLAIRNQLPLVVDAICTRG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 ADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 PTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 QDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 RESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 EIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 AVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLD 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA1 KPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDML 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA1 SKEPPWCDGSYCYECTARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKEPPWCDGSYCYECTARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNI 1150 1160 1170 1180 1190 1200 1210 pF1KA1 CFDVLTLGGVS ::::::::::: NP_001 CFDVLTLGGVS 1210 >>XP_011522228 (OMIM: 607927) PREDICTED: rabankyrin-5 is (1212 aa) initn: 7970 init1: 4476 opt: 7972 Z-score: 4090.4 bits: 768.9 E(85289): 0 Smith-Waterman score: 7972; 99.9% identity (99.9% similar) in 1212 aa overlap (1-1211:1-1212) 10 20 30 40 50 60 pF1KA1 MPTPRDCGRLRSRAGRSRAGAACSRGAPRAAREALDCRRCRDAGGKEVAKLEKHLMLLRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPTPRDCGRLRSRAGRSRAGAACSRGAPRAAREALDCRRCRDAGGKEVAKLEKHLMLLRQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 EYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 ISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTEL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 MKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 KEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 ALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 TLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 NEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 FAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 CRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 VSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDT 610 620 630 640 650 660 670 680 690 700 710 pF1KA1 MSDGQTLLHMAIQRQDSKSALFLLEHQADINV-RTQDGETALQLAIRNQLPLVVDAICTR :::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::: XP_011 MSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTR 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA1 GADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENN 730 740 750 760 770 780 780 790 800 810 820 830 pF1KA1 EPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVN 790 800 810 820 830 840 840 850 860 870 880 890 pF1KA1 AQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAIL 850 860 870 880 890 900 900 910 920 930 940 950 pF1KA1 KRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAG 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KA1 SEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALH 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA1 LAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPL 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KA1 DKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDM 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KA1 LSKEPPWCDGSYCYECTARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSKEPPWCDGSYCYECTARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCN 1150 1160 1170 1180 1190 1200 1200 1210 pF1KA1 ICFDVLTLGGVS :::::::::::: XP_011 ICFDVLTLGGVS 1210 >>XP_016880222 (OMIM: 607927) PREDICTED: rabankyrin-5 is (1273 aa) initn: 7654 init1: 7654 opt: 7654 Z-score: 3928.1 bits: 739.0 E(85289): 4.6e-212 Smith-Waterman score: 7654; 99.9% identity (100.0% similar) in 1166 aa overlap (46-1211:108-1273) 20 30 40 50 60 70 pF1KA1 RSRAGAACSRGAPRAAREALDCRRCRDAGGKEVAKLEKHLMLLRQEYVKLQKKLAETEKR .::::::::::::::::::::::::::::: XP_016 GEVSLLLRKSKLLSWHVLHPEGVHPSLAEEQEVAKLEKHLMLLRQEYVKLQKKLAETEKR 80 90 100 110 120 130 80 90 100 110 120 130 pF1KA1 CALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSW 140 150 160 170 180 190 140 150 160 170 180 190 pF1KA1 SLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRER 200 210 220 230 240 250 200 210 220 230 240 250 pF1KA1 CEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKM 260 270 280 290 300 310 260 270 280 290 300 310 pF1KA1 IKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIAT 320 330 340 350 360 370 320 330 340 350 360 370 pF1KA1 TLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALY 380 390 400 410 420 430 380 390 400 410 420 430 pF1KA1 SSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLD 440 450 460 470 480 490 440 450 460 470 480 490 pF1KA1 LELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAP 500 510 520 530 540 550 500 510 520 530 540 550 pF1KA1 DTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQ 560 570 580 590 600 610 560 570 580 590 600 610 pF1KA1 GANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHAT 620 630 640 650 660 670 620 630 640 650 660 670 pF1KA1 NNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQ 680 690 700 710 720 730 680 690 700 710 720 730 pF1KA1 DSKSALFLLEHQADINVRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSKSALFLLEHQADINVRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLW 740 750 760 770 780 790 740 750 760 770 780 790 pF1KA1 LALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNS 800 810 820 830 840 850 800 810 820 830 840 850 pF1KA1 PRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISS 860 870 880 890 900 910 860 870 880 890 900 910 pF1KA1 QHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRN 920 930 940 950 960 970 920 930 940 950 960 970 pF1KA1 FLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVN 980 990 1000 1010 1020 1030 980 990 1000 1010 1020 1030 pF1KA1 ELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLT 1040 1050 1060 1070 1080 1090 1040 1050 1060 1070 1080 1090 pF1KA1 ECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYM 1100 1110 1120 1130 1140 1150 1100 1110 1120 1130 1140 1150 pF1KA1 KGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDMLSKEPPWCDGSYCYEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDMLSKEPPWCDGSYCYEC 1160 1170 1180 1190 1200 1210 1160 1170 1180 1190 1200 1210 pF1KA1 TARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNICFDVLTLGGVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNICFDVLTLGGVS 1220 1230 1240 1250 1260 1270 >>NP_001316992 (OMIM: 607927) rabankyrin-5 isoform 4 [Ho (1169 aa) initn: 7653 init1: 7653 opt: 7653 Z-score: 3928.0 bits: 738.8 E(85289): 4.7e-212 Smith-Waterman score: 7653; 99.9% identity (100.0% similar) in 1166 aa overlap (46-1211:4-1169) 20 30 40 50 60 70 pF1KA1 RSRAGAACSRGAPRAAREALDCRRCRDAGGKEVAKLEKHLMLLRQEYVKLQKKLAETEKR .::::::::::::::::::::::::::::: NP_001 MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKR 10 20 30 80 90 100 110 120 130 pF1KA1 CALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSW 40 50 60 70 80 90 140 150 160 170 180 190 pF1KA1 SLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRER 100 110 120 130 140 150 200 210 220 230 240 250 pF1KA1 CEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKM 160 170 180 190 200 210 260 270 280 290 300 310 pF1KA1 IKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIAT 220 230 240 250 260 270 320 330 340 350 360 370 pF1KA1 TLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALY 280 290 300 310 320 330 380 390 400 410 420 430 pF1KA1 SSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLD 340 350 360 370 380 390 440 450 460 470 480 490 pF1KA1 LELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAP 400 410 420 430 440 450 500 510 520 530 540 550 pF1KA1 DTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQ 460 470 480 490 500 510 560 570 580 590 600 610 pF1KA1 GANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHAT 520 530 540 550 560 570 620 630 640 650 660 670 pF1KA1 NNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQ 580 590 600 610 620 630 680 690 700 710 720 730 pF1KA1 DSKSALFLLEHQADINVRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSKSALFLLEHQADINVRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLW 640 650 660 670 680 690 740 750 760 770 780 790 pF1KA1 LALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNS 700 710 720 730 740 750 800 810 820 830 840 850 pF1KA1 PRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISS 760 770 780 790 800 810 860 870 880 890 900 910 pF1KA1 QHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRN 820 830 840 850 860 870 920 930 940 950 960 970 pF1KA1 FLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVN 880 890 900 910 920 930 980 990 1000 1010 1020 1030 pF1KA1 ELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLT 940 950 960 970 980 990 1040 1050 1060 1070 1080 1090 pF1KA1 ECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYM 1000 1010 1020 1030 1040 1050 1100 1110 1120 1130 1140 1150 pF1KA1 KGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDMLSKEPPWCDGSYCYEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDMLSKEPPWCDGSYCYEC 1060 1070 1080 1090 1100 1110 1160 1170 1180 1190 1200 1210 pF1KA1 TARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNICFDVLTLGGVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNICFDVLTLGGVS 1120 1130 1140 1150 1160 >>NP_057460 (OMIM: 607927) rabankyrin-5 isoform 1 [Homo (1170 aa) initn: 7639 init1: 4145 opt: 7641 Z-score: 3921.9 bits: 737.7 E(85289): 1e-211 Smith-Waterman score: 7641; 99.8% identity (99.9% similar) in 1167 aa overlap (46-1211:4-1170) 20 30 40 50 60 70 pF1KA1 RSRAGAACSRGAPRAAREALDCRRCRDAGGKEVAKLEKHLMLLRQEYVKLQKKLAETEKR .::::::::::::::::::::::::::::: NP_057 MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKR 10 20 30 80 90 100 110 120 130 pF1KA1 CALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 CALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSW 40 50 60 70 80 90 140 150 160 170 180 190 pF1KA1 SLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRER 100 110 120 130 140 150 200 210 220 230 240 250 pF1KA1 CEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 CEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKM 160 170 180 190 200 210 260 270 280 290 300 310 pF1KA1 IKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 IKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIAT 220 230 240 250 260 270 320 330 340 350 360 370 pF1KA1 TLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 TLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALY 280 290 300 310 320 330 380 390 400 410 420 430 pF1KA1 SSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLD 340 350 360 370 380 390 440 450 460 470 480 490 pF1KA1 LELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 LELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAP 400 410 420 430 440 450 500 510 520 530 540 550 pF1KA1 DTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 DTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQ 460 470 480 490 500 510 560 570 580 590 600 610 pF1KA1 GANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 GANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHAT 520 530 540 550 560 570 620 630 640 650 660 670 pF1KA1 NNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 NNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQ 580 590 600 610 620 630 680 690 700 710 720 730 pF1KA1 DSKSALFLLEHQADINV-RTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPL ::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::: NP_057 DSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPL 640 650 660 670 680 690 740 750 760 770 780 790 pF1KA1 WLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 WLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVN 700 710 720 730 740 750 800 810 820 830 840 850 pF1KA1 SPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAIS 760 770 780 790 800 810 860 870 880 890 900 910 pF1KA1 SQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGR 820 830 840 850 860 870 920 930 940 950 960 970 pF1KA1 NFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 NFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKV 880 890 900 910 920 930 980 990 1000 1010 1020 1030 pF1KA1 NELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 NELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLL 940 950 960 970 980 990 1040 1050 1060 1070 1080 1090 pF1KA1 TECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 TECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAY 1000 1010 1020 1030 1040 1050 1100 1110 1120 1130 1140 1150 pF1KA1 MKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDMLSKEPPWCDGSYCYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDMLSKEPPWCDGSYCYE 1060 1070 1080 1090 1100 1110 1160 1170 1180 1190 1200 1210 pF1KA1 CTARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNICFDVLTLGGVS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 CTARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNICFDVLTLGGVS 1120 1130 1140 1150 1160 1170 >>XP_011522230 (OMIM: 607927) PREDICTED: rabankyrin-5 is (1157 aa) initn: 7584 init1: 4090 opt: 7586 Z-score: 3893.9 bits: 732.5 E(85289): 3.8e-210 Smith-Waterman score: 7586; 99.9% identity (99.9% similar) in 1157 aa overlap (56-1211:1-1157) 30 40 50 60 70 80 pF1KA1 GAPRAAREALDCRRCRDAGGKEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANK :::::::::::::::::::::::::::::: XP_011 MLLRQEYVKLQKKLAETEKRCALLAAQANK 10 20 30 90 100 110 120 130 140 pF1KA1 ESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKE 40 50 60 70 80 90 150 160 170 180 190 200 pF1KA1 LDLSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDLSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVN 100 110 120 130 140 150 210 220 230 240 250 260 pF1KA1 VRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLH 160 170 180 190 200 210 270 280 290 300 310 320 pF1KA1 KAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVD 220 230 240 250 260 270 330 340 350 360 370 380 pF1KA1 MVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVM 280 290 300 310 320 330 390 400 410 420 430 440 pF1KA1 SEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGST 340 350 360 370 380 390 450 460 470 480 490 500 pF1KA1 ALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQ 400 410 420 430 440 450 510 520 530 540 550 560 pF1KA1 RAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEE 460 470 480 490 500 510 570 580 590 600 610 620 pF1KA1 ALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFS 520 530 540 550 560 570 630 640 650 660 670 680 pF1KA1 LKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLE 580 590 600 610 620 630 690 700 710 720 730 740 pF1KA1 HQADINV-RTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLED ::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLED 640 650 660 670 680 690 750 760 770 780 790 800 pF1KA1 IASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGE 700 710 720 730 740 750 810 820 830 840 850 860 pF1KA1 GEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLL 760 770 780 790 800 810 870 880 890 900 910 920 pF1KA1 VSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNS 820 830 840 850 860 870 930 940 950 960 970 980 pF1KA1 DIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTA 880 890 900 910 920 930 990 1000 1010 1020 1030 1040 pF1KA1 LHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAF 940 950 960 970 980 990 1050 1060 1070 1080 1090 1100 pF1KA1 NLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRA 1000 1010 1020 1030 1040 1050 1110 1120 1130 1140 1150 1160 pF1KA1 IVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDMLSKEPPWCDGSYCYECTARFGVTTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDMLSKEPPWCDGSYCYECTARFGVTTR 1060 1070 1080 1090 1100 1110 1170 1180 1190 1200 1210 pF1KA1 KHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNICFDVLTLGGVS ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNICFDVLTLGGVS 1120 1130 1140 1150 >>XP_011522235 (OMIM: 607927) PREDICTED: rabankyrin-5 is (708 aa) initn: 4521 init1: 3508 opt: 4530 Z-score: 2338.2 bits: 443.9 E(85289): 1.7e-123 Smith-Waterman score: 4530; 96.8% identity (98.4% similar) in 709 aa overlap (504-1211:5-708) 480 490 500 510 520 530 pF1KA1 TSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWG :.:.: . ..: :.. .:...:. : XP_011 MGLHLMRTALQPDSSSA---AATQTHLTRRQ--G 10 20 540 550 560 570 580 590 pF1KA1 ETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAI 30 40 50 60 70 80 600 610 620 630 640 650 pF1KA1 AYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGS 90 100 110 120 130 140 660 670 680 690 700 710 pF1KA1 GAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINV-RTQDGETALQLAIRNQLPLV ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: XP_011 GAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLV 150 160 170 180 190 200 720 730 740 750 760 770 pF1KA1 VDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLH 210 220 230 240 250 260 780 790 800 810 820 830 pF1KA1 RAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLL 270 280 290 300 310 320 840 850 860 870 880 890 pF1KA1 EFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNN 330 340 350 360 370 380 900 910 920 930 940 950 pF1KA1 KSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPL 390 400 410 420 430 440 960 970 980 990 1000 1010 pF1KA1 HLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDE 450 460 470 480 490 500 1020 1030 1040 1050 1060 1070 pF1KA1 NGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLE 510 520 530 540 550 560 1080 1090 1100 1110 1120 1130 pF1KA1 CMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQL 570 580 590 600 610 620 1140 1150 1160 1170 1180 1190 pF1KA1 LFRLLDMLSKEPPWCDGSYCYECTARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFRLLDMLSKEPPWCDGSYCYECTARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLN 630 640 650 660 670 680 1200 1210 pF1KA1 KPVRVCNICFDVLTLGGVS ::::::::::::::::::: XP_011 KPVRVCNICFDVLTLGGVS 690 700 >>XP_011531845 (OMIM: 611122) PREDICTED: serine/threonin (1019 aa) initn: 241 init1: 136 opt: 509 Z-score: 287.1 bits: 64.9 E(85289): 3e-09 Smith-Waterman score: 575; 25.1% identity (53.0% similar) in 847 aa overlap (263-1064:77-872) 240 250 260 270 280 290 pF1KA1 ASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLN ::: : . ... : .. ...: XP_011 QAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILS-----GARVN 50 60 70 80 90 100 300 310 320 330 340 350 pF1KA1 EADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIK : . : :.. : .. :.:. :... ::. .: . : . .. .:.. XP_011 AKDSKWLTPLHRAVASCSE-MVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS 110 120 130 140 150 160 360 370 380 390 400 410 pF1KA1 NGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTP .:: :. . :::: .: : : .... ::. :.. : .. : :: XP_011 HGAEVTCKD-KKSYTPLHAAA-----------SSGMISVVKYLLDLGVDMNEPNAYGNTP 170 180 190 200 420 430 440 450 460 470 pF1KA1 LHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVN :::. . :.. : ..:..: . .. :...: : : :....: ... .: . : : XP_011 LHVACYNGQDVVVNELIDCGAI-VNQKNEKGFTPL-----HFAAASTHGALCLELL-VGN 210 220 230 240 250 260 480 490 500 510 520 530 pF1KA1 GTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKW :.. . .: :. :. .: : . . . .:: .. ..: XP_011 GADVNMKS-----------------KDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKN 270 280 290 300 540 550 560 570 580 590 pF1KA1 GETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMA :.:::: : :.: : :. .::. . ... .: . :.:....: . : . XP_011 GNTPLHIAARYGHELLINTLITSGADTAKRGIHGM-FPLHLAALSGFSDCC--RKLLSSG 310 320 330 340 350 360 600 610 620 630 640 pF1KA1 IAYNHPDVVSVILEQKANALHATNNLQII----PDFSLKDSRDQTVLGLALWTGMHTIAA . . :: . . : : . :... ::. ::. .. : : . . XP_011 FDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLF 370 380 390 400 410 420 650 660 670 680 690 700 pF1KA1 QLLGSGAAINDTMSDGQTLLHMAIQRQ-DSKSALFLLEHQADINVRTQDGETA------- :.::::..:: : : ::.: . :.: .::...:. ..: ..: .: XP_011 ALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAY 430 440 450 460 470 480 710 720 730 740 750 pF1KA1 -----LQLAIRNQLPLVVDAICTRGADM-SVPDEKGN-PPLWLALANNLEDIASTLVRHG ::: : .. :: : . : :.:: : :.... :: :: .. .. .::. XP_011 GHRLCLQL-IASETPLDV-LMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSL 490 500 510 520 530 760 770 780 790 800 pF1KA1 CDATCW---GPGPGGCLQTLLH-RAIDENNEPTACFLIRSGCDVNSPRQPGA-NGEGE-- : : : : . .: . : .:... .: . .: ::..: XP_011 LDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECL 540 550 560 570 580 590 810 820 830 840 850 pF1KA1 ---------EEARD-----GQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVA ..: : ::::: :.. : . : ::. ::::.:.: ::: .: . XP_011 RLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRG 600 610 620 630 640 650 860 870 880 890 900 pF1KA1 ISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQ---V . : .. :..: : .:: .: ::. . . . :.:. .. . . XP_011 AVTGHEECVDALLQHGAKCL-LRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATA 660 670 680 690 700 710 910 920 930 940 950 960 pF1KA1 DNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLL- ::.: . :: : :. : .:. . .: .... .. ..::: :: .: .. :. XP_011 DNHGYTALHWACYNGHETCVELLL--EQEVFQKTE-GNAFSPLHCAVINDNEGAAEMLID 720 730 740 750 760 770 970 980 990 1000 1010 1020 pF1KA1 -LAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRL :... :: .. .: :: :: : ..:: .... .:: .:.. : .:. .:. XP_011 TLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQT 780 790 800 810 820 830 1030 1040 1050 1060 1070 1080 pF1KA1 NNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGS :....:.. ... . .. ::. . :.:..: XP_011 NTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTP 840 850 860 870 880 890 1090 1100 1110 1120 1130 1140 pF1KA1 TVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDMLSKEPPWC XP_011 LHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSSS 900 910 920 930 940 950 >>NP_001182027 (OMIM: 611122) serine/threonine-protein p (899 aa) initn: 241 init1: 136 opt: 453 Z-score: 259.1 bits: 59.6 E(85289): 1.1e-07 Smith-Waterman score: 567; 25.9% identity (53.7% similar) in 829 aa overlap (246-1034:40-792) 220 230 240 250 260 270 pF1KA1 AEELNASTLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDV : .:.. : :: : ::: : . .: NP_001 ANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYT--PLHAAASSGMISV 10 20 30 40 50 60 280 290 300 310 320 330 pF1KA1 VFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLL : ::... .. :: . :. : .: . ... :.. : :.. ...:.. : NP_001 V-KYLLDLGVDM----NEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 70 80 90 100 110 120 340 350 360 370 380 390 pF1KA1 H-KGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEA : . . . .:. ::: :: . .. ::::..::.. ..: .. NP_001 HFAAASTHGALCLELLVGNGADVNMKSKDGK-TPLHMTALHGRFSRS-----------QT 130 140 150 160 170 400 410 420 430 440 450 pF1KA1 LLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHI ..:.:: . .:..: ::::.. :.: ... :. . : . .: : :: NP_001 IIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT-SGADTAKRGIHGMFPLHLA---- 180 190 200 210 220 460 470 480 490 500 510 pF1KA1 TVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEA ... : : .:.. : :.:: .:: :::.. : NP_001 ------ALSGFSDC-------------CRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLEC 230 240 250 260 520 530 540 550 560 570 pF1KA1 AALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPN-LQTEEALPLPKEA :.: : :: :...:.:..::: : . . :. .::. : :. . :: : NP_001 LNLLLNT-GADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 270 280 290 300 310 320 580 590 600 610 pF1KA1 ASLTSLADSVHL----QTP----------LHMAIAYNHPDVVSVIL-EQKANALHATNNL .: :. .: .: .:.. ::.: ...: : ..: :.. NP_001 TSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGT 330 340 350 360 370 380 620 630 640 650 660 670 pF1KA1 QIIPDFSLKDSRDQ-TVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDS ... : .:.: . : :: . : : :. : .. :.:.: : .: . NP_001 DMLSD---SDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHV 390 400 410 420 430 440 680 690 700 710 720 730 pF1KA1 KSALFLLEHQADINVRTQD-GETALQLAIRNQ----LPLVVDAICTRGADMSVPDEKGNP . . :... :.: :. .: .. : : : :.. ..: ... : .:. NP_001 ECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNA-VDIQDGNGQT 450 460 470 480 490 500 740 750 760 770 780 pF1KA1 PLWLALANNLEDIASTLVRHGCDATC---WGPGPGGCLQTLLHRAIDENNEPTACFLIRS :: :.. :. : . .:. .: .. :: .: :::. ..: . :.. NP_001 PLMLSVLNGHTDCVYSLLNKGANVDAKDKWG-------RTALHRGAVTGHEECVDALLQH 510 520 530 540 550 790 800 810 820 830 840 pF1KA1 G--CDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQ----DA : : . . : :.::.::.:. : .. ::. .:...:. : NP_001 GAKCLLRDSR--------------GRTPIHLSAACGHIGVLGALLQSAASMDANPATADN 560 570 580 590 600 850 860 870 880 890 900 pF1KA1 EGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRES .: : .: : . : . ..::. . .. .. . ....:. ::. ...:..: .: NP_001 HGYTALHWACYNGHETCVELLLEQ-EV-FQKTEGNAFSPLHCAV-INDNEGAAEMLIDTL 610 620 630 640 650 910 920 930 940 950 960 pF1KA1 GAA--EQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSE ::. . .:.:::. ::.:. .. .: . .:.: .:.::: :.. ::: .:.. :. NP_001 GASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSV--DSTGKTPLMMAAENGQT 660 670 680 690 700 710 970 980 990 1000 1010 pF1KA1 IIVRNLLL-AGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNA--- :. :. :.:... . ..:::::: .. : ..::. .: . :..:: NP_001 NTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLI--NATNAALQ 720 730 740 750 760 770 1020 1030 1040 1050 1060 1070 pF1KA1 --LHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMP ::.:. .: .. :: NP_001 TPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVS 780 790 800 810 820 830 >>XP_016861516 (OMIM: 611122) PREDICTED: serine/threonin (899 aa) initn: 241 init1: 136 opt: 453 Z-score: 259.1 bits: 59.6 E(85289): 1.1e-07 Smith-Waterman score: 567; 25.9% identity (53.7% similar) in 829 aa overlap (246-1034:40-792) 220 230 240 250 260 270 pF1KA1 AEELNASTLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDV : .:.. : :: : ::: : . .: XP_016 ANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYT--PLHAAASSGMISV 10 20 30 40 50 60 280 290 300 310 320 330 pF1KA1 VFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLL : ::... .. :: . :. : .: . ... :.. : :.. ...:.. : XP_016 V-KYLLDLGVDM----NEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 70 80 90 100 110 120 340 350 360 370 380 390 pF1KA1 H-KGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEA : . . . .:. ::: :: . .. ::::..::.. ..: .. XP_016 HFAAASTHGALCLELLVGNGADVNMKSKDGK-TPLHMTALHGRFSRS-----------QT 130 140 150 160 170 400 410 420 430 440 450 pF1KA1 LLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHI ..:.:: . .:..: ::::.. :.: ... :. . : . .: : :: XP_016 IIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT-SGADTAKRGIHGMFPLHLA---- 180 190 200 210 220 460 470 480 490 500 510 pF1KA1 TVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEA ... : : .:.. : :.:: .:: :::.. : XP_016 ------ALSGFSDC-------------CRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLEC 230 240 250 260 520 530 540 550 560 570 pF1KA1 AALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPN-LQTEEALPLPKEA :.: : :: :...:.:..::: : . . :. .::. : :. . :: : XP_016 LNLLLNT-GADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 270 280 290 300 310 320 580 590 600 610 pF1KA1 ASLTSLADSVHL----QTP----------LHMAIAYNHPDVVSVIL-EQKANALHATNNL .: :. .: .: .:.. ::.: ...: : ..: :.. XP_016 TSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGT 330 340 350 360 370 380 620 630 640 650 660 670 pF1KA1 QIIPDFSLKDSRDQ-TVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDS ... : .:.: . : :: . : : :. : .. :.:.: : .: . XP_016 DMLSD---SDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHV 390 400 410 420 430 440 680 690 700 710 720 730 pF1KA1 KSALFLLEHQADINVRTQD-GETALQLAIRNQ----LPLVVDAICTRGADMSVPDEKGNP . . :... :.: :. .: .. : : : :.. ..: ... : .:. XP_016 ECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNA-VDIQDGNGQT 450 460 470 480 490 500 740 750 760 770 780 pF1KA1 PLWLALANNLEDIASTLVRHGCDATC---WGPGPGGCLQTLLHRAIDENNEPTACFLIRS :: :.. :. : . .:. .: .. :: .: :::. ..: . :.. XP_016 PLMLSVLNGHTDCVYSLLNKGANVDAKDKWG-------RTALHRGAVTGHEECVDALLQH 510 520 530 540 550 790 800 810 820 830 840 pF1KA1 G--CDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQ----DA : : . . : :.::.::.:. : .. ::. .:...:. : XP_016 GAKCLLRDSR--------------GRTPIHLSAACGHIGVLGALLQSAASMDANPATADN 560 570 580 590 600 850 860 870 880 890 900 pF1KA1 EGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRES .: : .: : . : . ..::. . .. .. . ....:. ::. ...:..: .: XP_016 HGYTALHWACYNGHETCVELLLEQ-EV-FQKTEGNAFSPLHCAV-INDNEGAAEMLIDTL 610 620 630 640 650 910 920 930 940 950 960 pF1KA1 GAA--EQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSE ::. . .:.:::. ::.:. .. .: . .:.: .:.::: :.. ::: .:.. :. XP_016 GASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSV--DSTGKTPLMMAAENGQT 660 670 680 690 700 710 970 980 990 1000 1010 pF1KA1 IIVRNLLL-AGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNA--- :. :. :.:... . ..:::::: .. : ..::. .: . :..:: XP_016 NTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLI--NATNAALQ 720 730 740 750 760 770 1020 1030 1040 1050 1060 1070 pF1KA1 --LHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMP ::.:. .: .. :: XP_016 TPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVS 780 790 800 810 820 830 1211 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 01:25:09 2016 done: Fri Nov 4 01:25:12 2016 Total Scan time: 16.070 Total Display time: 0.560 Function used was FASTA [36.3.4 Apr, 2011]