FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1273, 602 aa 1>>>pF1KA1273 602 - 602 aa - 602 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.1115+/-0.000512; mu= 1.9092+/- 0.032 mean_var=296.5990+/-59.271, 0's: 0 Z-trim(116.6): 125 B-trim: 649 in 2/51 Lambda= 0.074471 statistics sampled from 27817 (27946) to 27817 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.673), E-opt: 0.2 (0.328), width: 16 Scan time: 9.750 The best scores are: opt bits E(85289) NP_001304167 (OMIM: 612317) ATPase family AAA doma ( 602) 3967 440.7 6.9e-123 XP_011540546 (OMIM: 612317) PREDICTED: ATPase fami ( 696) 3967 440.7 7.6e-123 NP_114127 (OMIM: 612317) ATPase family AAA domain- ( 648) 3652 406.8 1.1e-112 XP_011540545 (OMIM: 612317) PREDICTED: ATPase fami ( 480) 3185 356.5 1.2e-97 NP_060658 (OMIM: 612316) ATPase family AAA domain- ( 634) 3187 356.9 1.2e-97 XP_005244863 (OMIM: 612317) PREDICTED: ATPase fami ( 586) 3043 341.4 5.2e-93 NP_001164007 (OMIM: 612316) ATPase family AAA doma ( 507) 2894 325.3 3.1e-88 NP_001164006 (OMIM: 612316) ATPase family AAA doma ( 586) 2894 325.4 3.4e-88 XP_011540543 (OMIM: 612317) PREDICTED: ATPase fami ( 483) 2214 252.2 3e-66 XP_016857117 (OMIM: 612316) PREDICTED: ATPase fami ( 483) 2125 242.6 2.2e-63 >>NP_001304167 (OMIM: 612317) ATPase family AAA domain-c (602 aa) initn: 3967 init1: 3967 opt: 3967 Z-score: 2327.2 bits: 440.7 E(85289): 6.9e-123 Smith-Waterman score: 3967; 100.0% identity (100.0% similar) in 602 aa overlap (1-602:1-602) 10 20 30 40 50 60 pF1KA1 MQLEALNLLHTLVWARSLCRAGAVQTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQLEALNLLHTLVWARSLCRAGAVQTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 QIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 EAMRRATVEREMELRHKNEMLRVETEARARAKAERENADIIREQIRLKASEHRQTVLESI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAMRRATVEREMELRHKNEMLRVETEARARAKAERENADIIREQIRLKASEHRQTVLESI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 RTAGTLFGEGFRAFVTDRDKVTATVAGLTLLAVGVYSAKNATAVTGRFIEARLGKPSLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTAGTLFGEGFRAFVTDRDKVTATVAGLTLLAVGVYSAKNATAVTGRFIEARLGKPSLVR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 ETSRITVLEALRHPIQVSRRLLSRPQDVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETSRITVLEALRHPIQVSRRLLSRPQDVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 HILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 LLFMDEADAFLRKRATEEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLFMDEADAFLRKRATEEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINSR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 IDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGMS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 GREIAQLAVSWQATAYASKDGVLTEAMMDACVQDAVQQYRQKMRWLKAEGPGRGVEHPLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GREIAQLAVSWQATAYASKDGVLTEAMMDACVQDAVQQYRQKMRWLKAEGPGRGVEHPLS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 GVQGETLTSWSLATDPSYPCLAGPCTFRICSWMGTGLCPGPLSPRMSCGGGRPFCPPGHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVQGETLTSWSLATDPSYPCLAGPCTFRICSWMGTGLCPGPLSPRMSCGGGRPFCPPGHP 550 560 570 580 590 600 pF1KA1 LL :: NP_001 LL >>XP_011540546 (OMIM: 612317) PREDICTED: ATPase family A (696 aa) initn: 3967 init1: 3967 opt: 3967 Z-score: 2326.4 bits: 440.7 E(85289): 7.6e-123 Smith-Waterman score: 3967; 100.0% identity (100.0% similar) in 602 aa overlap (1-602:95-696) 10 20 30 pF1KA1 MQLEALNLLHTLVWARSLCRAGAVQTQERL :::::::::::::::::::::::::::::: XP_011 LEHSRYAKEALNLAQMQEQTLQLEQQSKLKMQLEALNLLHTLVWARSLCRAGAVQTQERL 70 80 90 100 110 120 40 50 60 70 80 90 pF1KA1 SGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKL 130 140 150 160 170 180 100 110 120 130 140 150 pF1KA1 ARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVETEARAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVETEARAR 190 200 210 220 230 240 160 170 180 190 200 210 pF1KA1 AKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAFVTDRDKVTATVAGLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAFVTDRDKVTATVAGLTL 250 260 270 280 290 300 220 230 240 250 260 270 pF1KA1 LAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDVLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDVLE 310 320 330 340 350 360 280 290 300 310 320 330 pF1KA1 GVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFAKKLALHSGMDYAIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFAKKLALHSGMDYAIM 370 380 390 400 410 420 340 350 360 370 380 390 pF1KA1 TGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRATEEISKDLRATLNAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRATEEISKDLRATLNAF 430 440 450 460 470 480 400 410 420 430 440 450 pF1KA1 LYHMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEERERLVRLHFDNCVLKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYHMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEERERLVRLHFDNCVLKP 490 500 510 520 530 540 460 470 480 490 500 510 pF1KA1 ATEGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASKDGVLTEAMMDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ATEGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASKDGVLTEAMMDA 550 560 570 580 590 600 520 530 540 550 560 570 pF1KA1 CVQDAVQQYRQKMRWLKAEGPGRGVEHPLSGVQGETLTSWSLATDPSYPCLAGPCTFRIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CVQDAVQQYRQKMRWLKAEGPGRGVEHPLSGVQGETLTSWSLATDPSYPCLAGPCTFRIC 610 620 630 640 650 660 580 590 600 pF1KA1 SWMGTGLCPGPLSPRMSCGGGRPFCPPGHPLL :::::::::::::::::::::::::::::::: XP_011 SWMGTGLCPGPLSPRMSCGGGRPFCPPGHPLL 670 680 690 >>NP_114127 (OMIM: 612317) ATPase family AAA domain-cont (648 aa) initn: 3652 init1: 3652 opt: 3652 Z-score: 2143.9 bits: 406.8 E(85289): 1.1e-112 Smith-Waterman score: 3652; 99.8% identity (100.0% similar) in 556 aa overlap (47-602:93-648) 20 30 40 50 60 70 pF1KA1 SLCRAGAVQTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEE :.:::::::::::::::::::::::::::: NP_114 RELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEE 70 80 90 100 110 120 80 90 100 110 120 130 pF1KA1 TRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 TRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRH 130 140 150 160 170 180 140 150 160 170 180 190 pF1KA1 KNEMLRVETEARARAKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAFVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 KNEMLRVETEARARAKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAFVT 190 200 210 220 230 240 200 210 220 230 240 250 pF1KA1 DRDKVTATVAGLTLLAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHPIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 DRDKVTATVAGLTLLAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHPIQ 250 260 270 280 290 300 260 270 280 290 300 310 pF1KA1 VSRRLLSRPQDVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 VSRRLLSRPQDVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFA 310 320 330 340 350 360 320 330 340 350 360 370 pF1KA1 KKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 KKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRAT 370 380 390 400 410 420 380 390 400 410 420 430 pF1KA1 EEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 EEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEERE 430 440 450 460 470 480 440 450 460 470 480 490 pF1KA1 RLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 RLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAY 490 500 510 520 530 540 500 510 520 530 540 550 pF1KA1 ASKDGVLTEAMMDACVQDAVQQYRQKMRWLKAEGPGRGVEHPLSGVQGETLTSWSLATDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 ASKDGVLTEAMMDACVQDAVQQYRQKMRWLKAEGPGRGVEHPLSGVQGETLTSWSLATDP 550 560 570 580 590 600 560 570 580 590 600 pF1KA1 SYPCLAGPCTFRICSWMGTGLCPGPLSPRMSCGGGRPFCPPGHPLL :::::::::::::::::::::::::::::::::::::::::::::: NP_114 SYPCLAGPCTFRICSWMGTGLCPGPLSPRMSCGGGRPFCPPGHPLL 610 620 630 640 >>XP_011540545 (OMIM: 612317) PREDICTED: ATPase family A (480 aa) initn: 3185 init1: 3185 opt: 3185 Z-score: 1874.3 bits: 356.5 E(85289): 1.2e-97 Smith-Waterman score: 3185; 100.0% identity (100.0% similar) in 480 aa overlap (123-602:1-480) 100 110 120 130 140 150 pF1KA1 QRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVETEARARAK :::::::::::::::::::::::::::::: XP_011 MRRATVEREMELRHKNEMLRVETEARARAK 10 20 30 160 170 180 190 200 210 pF1KA1 AERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAFVTDRDKVTATVAGLTLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAFVTDRDKVTATVAGLTLLA 40 50 60 70 80 90 220 230 240 250 260 270 pF1KA1 VGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDVLEGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDVLEGV 100 110 120 130 140 150 280 290 300 310 320 330 pF1KA1 VLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFAKKLALHSGMDYAIMTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFAKKLALHSGMDYAIMTG 160 170 180 190 200 210 340 350 360 370 380 390 pF1KA1 GDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRATEEISKDLRATLNAFLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRATEEISKDLRATLNAFLY 220 230 240 250 260 270 400 410 420 430 440 450 pF1KA1 HMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEERERLVRLHFDNCVLKPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEERERLVRLHFDNCVLKPAT 280 290 300 310 320 330 460 470 480 490 500 510 pF1KA1 EGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASKDGVLTEAMMDACV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASKDGVLTEAMMDACV 340 350 360 370 380 390 520 530 540 550 560 570 pF1KA1 QDAVQQYRQKMRWLKAEGPGRGVEHPLSGVQGETLTSWSLATDPSYPCLAGPCTFRICSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QDAVQQYRQKMRWLKAEGPGRGVEHPLSGVQGETLTSWSLATDPSYPCLAGPCTFRICSW 400 410 420 430 440 450 580 590 600 pF1KA1 MGTGLCPGPLSPRMSCGGGRPFCPPGHPLL :::::::::::::::::::::::::::::: XP_011 MGTGLCPGPLSPRMSCGGGRPFCPPGHPLL 460 470 480 >>NP_060658 (OMIM: 612316) ATPase family AAA domain-cont (634 aa) initn: 3205 init1: 3179 opt: 3187 Z-score: 1874.0 bits: 356.9 E(85289): 1.2e-97 Smith-Waterman score: 3187; 93.5% identity (97.8% similar) in 536 aa overlap (1-536:95-630) 10 20 30 pF1KA1 MQLEALNLLHTLVWARSLCRAGAVQTQERL :.::::.:::::::: :::::::::::::: NP_060 LEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRAGAVQTQERL 70 80 90 100 110 120 40 50 60 70 80 90 pF1KA1 SGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 SGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKL 130 140 150 160 170 180 100 110 120 130 140 150 pF1KA1 ARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVETEARAR ::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::: NP_060 ARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARAR 190 200 210 220 230 240 160 170 180 190 200 210 pF1KA1 AKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAFVTDRDKVTATVAGLTL :::::::::::::::::::.::::::::::::::::::::::::::: :::::::::::: NP_060 AKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVAGLTL 250 260 270 280 290 300 220 230 240 250 260 270 pF1KA1 LAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDVLE :::::::::::: :.::::::::::::::::::::::::::::::::::::::::::.:: NP_060 LAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDALE 310 320 330 340 350 360 280 290 300 310 320 330 pF1KA1 GVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFAKKLALHSGMDYAIM ::::::::::::::::::::::::::.:::.::.:::::::::::::::::::::::::: NP_060 GVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIM 370 380 390 400 410 420 340 350 360 370 380 390 pF1KA1 TGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRATEEISKDLRATLNAF :::::::::::::::::::::::::::::::::.:::::::::::::.::.::::::::: NP_060 TGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAF 430 440 450 460 470 480 400 410 420 430 440 450 pF1KA1 LYHMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEERERLVRLHFDNCVLKP ::. :::::::::::::: ::::: :::.::. ::::::: :::::::::..::. :::: NP_060 LYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKP 490 500 510 520 530 540 460 470 480 490 500 510 pF1KA1 ATEGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASKDGVLTEAMMDA :::::.::::::::::::::::::::::::::::::::::::::::::.::::::::::. NP_060 ATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASEDGVLTEAMMDT 550 560 570 580 590 600 520 530 540 550 560 570 pF1KA1 CVQDAVQQYRQKMRWLKAEGPGRGVEHPLSGVQGETLTSWSLATDPSYPCLAGPCTFRIC :::::::..::: :::::::::: : NP_060 RVQDAVQQHQQKMCWLKAEGPGRGDEPSPS 610 620 630 >>XP_005244863 (OMIM: 612317) PREDICTED: ATPase family A (586 aa) initn: 3034 init1: 3034 opt: 3043 Z-score: 1790.8 bits: 341.4 E(85289): 5.2e-93 Smith-Waterman score: 3043; 97.0% identity (98.2% similar) in 494 aa overlap (47-540:93-586) 20 30 40 50 60 70 pF1KA1 SLCRAGAVQTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEE :.:::::::::::::::::::::::::::: XP_005 RELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEE 70 80 90 100 110 120 80 90 100 110 120 130 pF1KA1 TRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRH 130 140 150 160 170 180 140 150 160 170 180 190 pF1KA1 KNEMLRVETEARARAKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAFVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KNEMLRVETEARARAKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAFVT 190 200 210 220 230 240 200 210 220 230 240 250 pF1KA1 DRDKVTATVAGLTLLAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHPIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DRDKVTATVAGLTLLAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHPIQ 250 260 270 280 290 300 260 270 280 290 300 310 pF1KA1 VSRRLLSRPQDVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VSRRLLSRPQDVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFA 310 320 330 340 350 360 320 330 340 350 360 370 pF1KA1 KKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRAT 370 380 390 400 410 420 380 390 400 410 420 430 pF1KA1 EEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEERE 430 440 450 460 470 480 440 450 460 470 480 490 pF1KA1 RLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAY 490 500 510 520 530 540 500 510 520 530 540 550 pF1KA1 ASKDGVLTEAMMDACVQDAVQQYRQKMRWLKAEGPGRGVEHPLSGVQGETLTSWSLATDP ::.::::::::::. :::::::..: ::::: :: :.: : XP_005 ASEDGVLTEAMMDTRVQDAVQQHQQMMRWLKRGRPGPEDEQPSS 550 560 570 580 560 570 580 590 600 pF1KA1 SYPCLAGPCTFRICSWMGTGLCPGPLSPRMSCGGGRPFCPPGHPLL >>NP_001164007 (OMIM: 612316) ATPase family AAA domain-c (507 aa) initn: 2913 init1: 2887 opt: 2894 Z-score: 1705.0 bits: 325.3 E(85289): 3.1e-88 Smith-Waterman score: 2894; 93.3% identity (97.8% similar) in 490 aa overlap (47-536:14-503) 20 30 40 50 60 70 pF1KA1 SLCRAGAVQTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEE :.:::::::::::::::::::::::::::: NP_001 MQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEE 10 20 30 40 80 90 100 110 120 130 pF1KA1 TRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRH 50 60 70 80 90 100 140 150 160 170 180 190 pF1KA1 KNEMLRVETEARARAKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAFVT ::::::::.::::::::::::::::::::::::.:::::::::::::::::::::::::: NP_001 KNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVT 110 120 130 140 150 160 200 210 220 230 240 250 pF1KA1 DRDKVTATVAGLTLLAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHPIQ : :::::::::::::::::::::::: :.::::::::::::::::::::::::::::::: NP_001 DWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQ 170 180 190 200 210 220 260 270 280 290 300 310 pF1KA1 VSRRLLSRPQDVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFA :::::::::::.::::::::::::::::::::::::::::.:::.::.:::::::::::: NP_001 VSRRLLSRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFA 230 240 250 260 270 280 320 330 340 350 360 370 pF1KA1 KKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRAT :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: NP_001 KKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRAT 290 300 310 320 330 340 380 390 400 410 420 430 pF1KA1 EEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEERE :.::.:::::::::::. :::::::::::::: ::::: :::.::. ::::::: ::::: NP_001 EKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERE 350 360 370 380 390 400 440 450 460 470 480 490 pF1KA1 RLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAY ::::..::. :::::::::.:::::::::::::::::::::::::::::::::::::::: NP_001 RLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAY 410 420 430 440 450 460 500 510 520 530 540 550 pF1KA1 ASKDGVLTEAMMDACVQDAVQQYRQKMRWLKAEGPGRGVEHPLSGVQGETLTSWSLATDP ::.::::::::::. :::::::..::: :::::::::: : NP_001 ASEDGVLTEAMMDTRVQDAVQQHQQKMCWLKAEGPGRGDEPSPS 470 480 490 500 560 570 580 590 600 pF1KA1 SYPCLAGPCTFRICSWMGTGLCPGPLSPRMSCGGGRPFCPPGHPLL >>NP_001164006 (OMIM: 612316) ATPase family AAA domain-c (586 aa) initn: 2913 init1: 2887 opt: 2894 Z-score: 1704.3 bits: 325.4 E(85289): 3.4e-88 Smith-Waterman score: 2894; 93.3% identity (97.8% similar) in 490 aa overlap (47-536:93-582) 20 30 40 50 60 70 pF1KA1 SLCRAGAVQTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEE :.:::::::::::::::::::::::::::: NP_001 RELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEE 70 80 90 100 110 120 80 90 100 110 120 130 pF1KA1 TRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRH 130 140 150 160 170 180 140 150 160 170 180 190 pF1KA1 KNEMLRVETEARARAKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAFVT ::::::::.::::::::::::::::::::::::.:::::::::::::::::::::::::: NP_001 KNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVT 190 200 210 220 230 240 200 210 220 230 240 250 pF1KA1 DRDKVTATVAGLTLLAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHPIQ : :::::::::::::::::::::::: :.::::::::::::::::::::::::::::::: NP_001 DWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQ 250 260 270 280 290 300 260 270 280 290 300 310 pF1KA1 VSRRLLSRPQDVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFA :::::::::::.::::::::::::::::::::::::::::.:::.::.:::::::::::: NP_001 VSRRLLSRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFA 310 320 330 340 350 360 320 330 340 350 360 370 pF1KA1 KKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRAT :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: NP_001 KKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRAT 370 380 390 400 410 420 380 390 400 410 420 430 pF1KA1 EEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEERE :.::.:::::::::::. :::::::::::::: ::::: :::.::. ::::::: ::::: NP_001 EKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERE 430 440 450 460 470 480 440 450 460 470 480 490 pF1KA1 RLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAY ::::..::. :::::::::.:::::::::::::::::::::::::::::::::::::::: NP_001 RLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAY 490 500 510 520 530 540 500 510 520 530 540 550 pF1KA1 ASKDGVLTEAMMDACVQDAVQQYRQKMRWLKAEGPGRGVEHPLSGVQGETLTSWSLATDP ::.::::::::::. :::::::..::: :::::::::: : NP_001 ASEDGVLTEAMMDTRVQDAVQQHQQKMCWLKAEGPGRGDEPSPS 550 560 570 580 560 570 580 590 600 pF1KA1 SYPCLAGPCTFRICSWMGTGLCPGPLSPRMSCGGGRPFCPPGHPLL >>XP_011540543 (OMIM: 612317) PREDICTED: ATPase family A (483 aa) initn: 2214 init1: 2214 opt: 2214 Z-score: 1310.5 bits: 252.2 E(85289): 3e-66 Smith-Waterman score: 2214; 99.7% identity (100.0% similar) in 353 aa overlap (47-399:93-445) 20 30 40 50 60 70 pF1KA1 SLCRAGAVQTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEE :.:::::::::::::::::::::::::::: XP_011 RELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEE 70 80 90 100 110 120 80 90 100 110 120 130 pF1KA1 TRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRH 130 140 150 160 170 180 140 150 160 170 180 190 pF1KA1 KNEMLRVETEARARAKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAFVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KNEMLRVETEARARAKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAFVT 190 200 210 220 230 240 200 210 220 230 240 250 pF1KA1 DRDKVTATVAGLTLLAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHPIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DRDKVTATVAGLTLLAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHPIQ 250 260 270 280 290 300 260 270 280 290 300 310 pF1KA1 VSRRLLSRPQDVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSRRLLSRPQDVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFA 310 320 330 340 350 360 320 330 340 350 360 370 pF1KA1 KKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRAT 370 380 390 400 410 420 380 390 400 410 420 430 pF1KA1 EEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEERE ::::::::::::::::::::::: XP_011 EEISKDLRATLNAFLYHMGQHSNNPSHVSHGGSSPAGRPWLTLQARWAPGSAAAVRRSLE 430 440 450 460 470 480 >>XP_016857117 (OMIM: 612316) PREDICTED: ATPase family A (483 aa) initn: 2125 init1: 2125 opt: 2125 Z-score: 1258.8 bits: 242.6 E(85289): 2.2e-63 Smith-Waterman score: 2125; 95.8% identity (99.2% similar) in 353 aa overlap (47-399:93-445) 20 30 40 50 60 70 pF1KA1 SLCRAGAVQTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEE :.:::::::::::::::::::::::::::: XP_016 RELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEE 70 80 90 100 110 120 80 90 100 110 120 130 pF1KA1 TRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRH 130 140 150 160 170 180 140 150 160 170 180 190 pF1KA1 KNEMLRVETEARARAKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAFVT ::::::::.::::::::::::::::::::::::.:::::::::::::::::::::::::: XP_016 KNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVT 190 200 210 220 230 240 200 210 220 230 240 250 pF1KA1 DRDKVTATVAGLTLLAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHPIQ : :::::::::::::::::::::::: :.::::::::::::::::::::::::::::::: XP_016 DWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQ 250 260 270 280 290 300 260 270 280 290 300 310 pF1KA1 VSRRLLSRPQDVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFA :::::::::::.::::::::::::::::::::::::::::.:::.::.:::::::::::: XP_016 VSRRLLSRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFA 310 320 330 340 350 360 320 330 340 350 360 370 pF1KA1 KKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRAT :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: XP_016 KKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRAT 370 380 390 400 410 420 380 390 400 410 420 430 pF1KA1 EEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEERE :.::.:::::::::::. ::::: XP_016 EKISEDLRATLNAFLYRTGQHSNNPSHVSHGGSSPAGRPWLTPQARWAPRSAAAGGCSLE 430 440 450 460 470 480 602 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 20:54:07 2016 done: Wed Nov 2 20:54:09 2016 Total Scan time: 9.750 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]