FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1315, 1981 aa 1>>>pF1KA1315 1981 - 1981 aa - 1981 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.9853+/-0.00056; mu= 13.8640+/- 0.035 mean_var=221.7616+/-44.015, 0's: 0 Z-trim(112.8): 163 B-trim: 119 in 1/52 Lambda= 0.086125 statistics sampled from 21765 (21924) to 21765 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.591), E-opt: 0.2 (0.257), width: 16 Scan time: 19.190 The best scores are: opt bits E(85289) NP_036247 (OMIM: 606880) CASP8-associated protein (1982) 12958 1625.5 0 NP_001131139 (OMIM: 606880) CASP8-associated prote (1982) 12958 1625.5 0 NP_001131140 (OMIM: 606880) CASP8-associated prote (1982) 12958 1625.5 0 XP_016864545 (OMIM: 609268) PREDICTED: splicing re ( 359) 226 42.8 0.0082 NP_001310463 (OMIM: 609268) splicing regulatory gl ( 359) 226 42.8 0.0082 >>NP_036247 (OMIM: 606880) CASP8-associated protein 2 [H (1982 aa) initn: 11467 init1: 11467 opt: 12958 Z-score: 8712.1 bits: 1625.5 E(85289): 0 Smith-Waterman score: 12958; 99.9% identity (99.9% similar) in 1982 aa overlap (1-1981:1-1982) 10 20 30 40 50 60 pF1KA1 MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA1 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA1 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA1 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA1 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA1 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KA1 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KA1 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KA1 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KA1 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KA1 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KA1 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 pF1KA1 TQDASSEAKSEGN-PALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE ::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::: NP_036 TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE 1750 1760 1770 1780 1790 1800 1800 1810 1820 1830 1840 1850 pF1KA1 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK 1810 1820 1830 1840 1850 1860 1860 1870 1880 1890 1900 1910 pF1KA1 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK 1870 1880 1890 1900 1910 1920 1920 1930 1940 1950 1960 1970 pF1KA1 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK 1930 1940 1950 1960 1970 1980 1980 pF1KA1 CR :: NP_036 CR >>NP_001131139 (OMIM: 606880) CASP8-associated protein 2 (1982 aa) initn: 11467 init1: 11467 opt: 12958 Z-score: 8712.1 bits: 1625.5 E(85289): 0 Smith-Waterman score: 12958; 99.9% identity (99.9% similar) in 1982 aa overlap (1-1981:1-1982) 10 20 30 40 50 60 pF1KA1 MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA1 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA1 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA1 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA1 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA1 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KA1 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KA1 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KA1 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KA1 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KA1 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KA1 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 pF1KA1 TQDASSEAKSEGN-PALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE ::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE 1750 1760 1770 1780 1790 1800 1800 1810 1820 1830 1840 1850 pF1KA1 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK 1810 1820 1830 1840 1850 1860 1860 1870 1880 1890 1900 1910 pF1KA1 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK 1870 1880 1890 1900 1910 1920 1920 1930 1940 1950 1960 1970 pF1KA1 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK 1930 1940 1950 1960 1970 1980 1980 pF1KA1 CR :: NP_001 CR >>NP_001131140 (OMIM: 606880) CASP8-associated protein 2 (1982 aa) initn: 11467 init1: 11467 opt: 12958 Z-score: 8712.1 bits: 1625.5 E(85289): 0 Smith-Waterman score: 12958; 99.9% identity (99.9% similar) in 1982 aa overlap (1-1981:1-1982) 10 20 30 40 50 60 pF1KA1 MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA1 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA1 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA1 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA1 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA1 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KA1 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KA1 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KA1 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KA1 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KA1 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KA1 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 pF1KA1 TQDASSEAKSEGN-PALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE ::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE 1750 1760 1770 1780 1790 1800 1800 1810 1820 1830 1840 1850 pF1KA1 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK 1810 1820 1830 1840 1850 1860 1860 1870 1880 1890 1900 1910 pF1KA1 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK 1870 1880 1890 1900 1910 1920 1920 1930 1940 1950 1960 1970 pF1KA1 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK 1930 1940 1950 1960 1970 1980 1980 pF1KA1 CR :: NP_001 CR >>XP_016864545 (OMIM: 609268) PREDICTED: splicing regula (359 aa) initn: 226 init1: 85 opt: 226 Z-score: 171.5 bits: 42.8 E(85289): 0.0082 Smith-Waterman score: 267; 22.5% identity (58.3% similar) in 386 aa overlap (165-544:4-358) 140 150 160 170 180 190 pF1KA1 NLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTS .. . .:.. : ..:.: .: .. .. XP_016 MTPQAAAKELEEVMKRVREAQSFISAAIEPESG 10 20 30 200 210 220 230 240 250 pF1KA1 LPNLEKEGKPHSDKRSTSHLPT---SVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIR : .: :. .: :: :. . : .:. . :::: . : ..: ::... XP_016 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNR--SRSRQKDRRRSKSP-- 40 50 60 70 80 260 270 280 290 300 310 pF1KA1 HSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDS :.. ... :: ::. : . . . . .. .... :: : :.. . : XP_016 HKKRSKSRER-RKSRSRSHSRDKRK--DTREKIK---EKERVKEKDREKEREREKEREKE 90 100 110 120 130 140 320 330 340 350 360 370 pF1KA1 DYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQK .:. . . :.: :. :...:.. ::..:. .. .... : ::::... .: XP_016 KERGKNKDRDKEREKDREK-----DKEKDREREREKEHEKDRDKEKEKEQDKEKER--EK 150 160 170 180 190 380 390 400 410 420 pF1KA1 PKSVVKDQDHWRRSERASL--PHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQ .: :. :. :.... : :.: : :..::. . ..::. . . .. .. . . XP_016 DRS--KEIDEKRKKDKKSRTPPRSYNASRRSRSSSRER-RRRRSRSSSRSPRTSKTIKRK 200 210 220 230 240 250 430 440 450 460 470 480 pF1KA1 DGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNE ..: :: : .. :. . :: : . . . ::.:. . :: :.... . . : XP_016 SSRSPSPRSRNKKDKKRE-KERDHISE------RRERERSTSMRKS---SNDRDGKEKLE 260 270 280 290 300 490 500 510 520 530 540 pF1KA1 KRVPTEHLQKTNKETKKTTT-DLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNE : . . .. ::: .... .. .. :.:..... :: . ....:. :.:. XP_016 KNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQ-LNEENLSTKTEAV 310 320 330 340 350 550 560 570 580 590 600 pF1KA1 TKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQVKTVAYVPS >>NP_001310463 (OMIM: 609268) splicing regulatory glutam (359 aa) initn: 226 init1: 85 opt: 226 Z-score: 171.5 bits: 42.8 E(85289): 0.0082 Smith-Waterman score: 267; 22.5% identity (58.3% similar) in 386 aa overlap (165-544:4-358) 140 150 160 170 180 190 pF1KA1 NLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTS .. . .:.. : ..:.: .: .. .. NP_001 MTPQAAAKELEEVMKRVREAQSFISAAIEPESG 10 20 30 200 210 220 230 240 250 pF1KA1 LPNLEKEGKPHSDKRSTSHLPT---SVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIR : .: :. .: :: :. . : .:. . :::: . : ..: ::... NP_001 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNR--SRSRQKDRRRSKSP-- 40 50 60 70 80 260 270 280 290 300 310 pF1KA1 HSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDS :.. ... :: ::. : . . . . .. .... :: : :.. . : NP_001 HKKRSKSRER-RKSRSRSHSRDKRK--DTREKIK---EKERVKEKDREKEREREKEREKE 90 100 110 120 130 140 320 330 340 350 360 370 pF1KA1 DYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQK .:. . . :.: :. :...:.. ::..:. .. .... : ::::... .: NP_001 KERGKNKDRDKEREKDREK-----DKEKDREREREKEHEKDRDKEKEKEQDKEKER--EK 150 160 170 180 190 380 390 400 410 420 pF1KA1 PKSVVKDQDHWRRSERASL--PHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQ .: :. :. :.... : :.: : :..::. . ..::. . . .. .. . . NP_001 DRS--KEIDEKRKKDKKSRTPPRSYNASRRSRSSSRER-RRRRSRSSSRSPRTSKTIKRK 200 210 220 230 240 250 430 440 450 460 470 480 pF1KA1 DGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNE ..: :: : .. :. . :: : . . . ::.:. . :: :.... . . : NP_001 SSRSPSPRSRNKKDKKRE-KERDHISE------RRERERSTSMRKS---SNDRDGKEKLE 260 270 280 290 300 490 500 510 520 530 540 pF1KA1 KRVPTEHLQKTNKETKKTTT-DLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNE : . . .. ::: .... .. .. :.:..... :: . ....:. :.:. NP_001 KNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQ-LNEENLSTKTEAV 310 320 330 340 350 550 560 570 580 590 600 pF1KA1 TKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQVKTVAYVPS 1981 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 19:59:14 2016 done: Thu Nov 3 19:59:17 2016 Total Scan time: 19.190 Total Display time: 0.490 Function used was FASTA [36.3.4 Apr, 2011]