FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1390, 469 aa 1>>>pF1KA1390 469 - 469 aa - 469 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.6259+/-0.000775; mu= 7.9957+/- 0.047 mean_var=133.2733+/-27.005, 0's: 0 Z-trim(113.3): 16 B-trim: 214 in 1/51 Lambda= 0.111097 statistics sampled from 13971 (13981) to 13971 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.768), E-opt: 0.2 (0.429), width: 16 Scan time: 3.420 The best scores are: opt bits E(32554) CCDS976.1 FAM63A gene_id:55793|Hs108|chr1 ( 469) 3194 522.9 2.7e-148 CCDS53361.1 FAM63A gene_id:55793|Hs108|chr1 ( 517) 3194 523.0 3e-148 CCDS55635.1 FAM63A gene_id:55793|Hs108|chr1 ( 374) 2534 417.1 1.6e-116 CCDS30854.1 FAM63A gene_id:55793|Hs108|chr1 ( 327) 2180 360.3 1.7e-99 CCDS42046.1 FAM63B gene_id:54629|Hs108|chr15 ( 621) 1419 238.5 1.5e-62 CCDS45268.1 FAM63B gene_id:54629|Hs108|chr15 ( 620) 1409 236.9 4.6e-62 >>CCDS976.1 FAM63A gene_id:55793|Hs108|chr1 (469 aa) initn: 3194 init1: 3194 opt: 3194 Z-score: 2775.7 bits: 522.9 E(32554): 2.7e-148 Smith-Waterman score: 3194; 99.8% identity (99.8% similar) in 469 aa overlap (1-469:1-469) 10 20 30 40 50 60 pF1KA1 MEYHQPEDPAPGKAGTAEAVIPENHEVLAGPDEHPQDTDARDADGEAREREPADQALLPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS97 MEYHQPEDPAPGKAGTAEAVIPENHEVLAGPDEHPQDTDARDADGEAREREPADQALLPS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 QCGDNLESPLPEASSAPPGPTLGTLPEVETIRACSMPQELPQSPRTRQPEPDFYCVKWIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS97 QCGDNLESPLPEASSAPPGPTLGTLPEVETIRACSMPQELPQSPRTRQPEPDFYCVKWIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 WKGEQTPIITQSTNGPCPLLAIMNILFLQWKVKLPPQKEVITSDELMAHLGNCLLSIKPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS97 WKGEQTPIITQSTNGPCPLLAIMNILFLQWKVKLPPQKEVITSDELMAHLGNCLLSIKPQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 EKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLLGIPLYHGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS97 EKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLLGIPLYHGW 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 LVDPQSPEAVRAVGKLSYNQLVERIITCKHSSDTNLVTEGLIAEQFLETTAAQLTYHGLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS97 LVDPQSPEAVRAVGKLSYNQLVERIITCKHSSDTNLVTEGLIAEQFLETTAAQLTYHGLC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 ELTAAAKEGELSVFFRNNHFSTMTKHKSHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS97 ELTAAAKEGELSVFFRNNHFSTMTKHKSHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 DSDFHLSHSLGKGPGAEGGSGSPEKQLQVDQDYLIALSLQQQQPRGPLGLTDLELAQQLQ :::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::: CCDS97 DSDFHLSHSLGKGPGAEGGSGSPETQLQVDQDYLIALSLQQQQPRGPLGLTDLELAQQLQ 370 380 390 400 410 420 430 440 450 460 pF1KA1 QEEYQQQQAAQPVRMRTRVLSLQGRGATSGRPAGERRQRPKHESDCILL ::::::::::::::::::::::::::::::::::::::::::::::::: CCDS97 QEEYQQQQAAQPVRMRTRVLSLQGRGATSGRPAGERRQRPKHESDCILL 430 440 450 460 >>CCDS53361.1 FAM63A gene_id:55793|Hs108|chr1 (517 aa) initn: 3194 init1: 3194 opt: 3194 Z-score: 2775.1 bits: 523.0 E(32554): 3e-148 Smith-Waterman score: 3194; 99.8% identity (99.8% similar) in 469 aa overlap (1-469:49-517) 10 20 30 pF1KA1 MEYHQPEDPAPGKAGTAEAVIPENHEVLAG :::::::::::::::::::::::::::::: CCDS53 CHSFASQAWLRQVPEVSKHLQCPSAKSLLTMEYHQPEDPAPGKAGTAEAVIPENHEVLAG 20 30 40 50 60 70 40 50 60 70 80 90 pF1KA1 PDEHPQDTDARDADGEAREREPADQALLPSQCGDNLESPLPEASSAPPGPTLGTLPEVET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 PDEHPQDTDARDADGEAREREPADQALLPSQCGDNLESPLPEASSAPPGPTLGTLPEVET 80 90 100 110 120 130 100 110 120 130 140 150 pF1KA1 IRACSMPQELPQSPRTRQPEPDFYCVKWIPWKGEQTPIITQSTNGPCPLLAIMNILFLQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 IRACSMPQELPQSPRTRQPEPDFYCVKWIPWKGEQTPIITQSTNGPCPLLAIMNILFLQW 140 150 160 170 180 190 160 170 180 190 200 210 pF1KA1 KVKLPPQKEVITSDELMAHLGNCLLSIKPQEKSEGLQLNFQQNVDDAMTVLPKLATGLDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 KVKLPPQKEVITSDELMAHLGNCLLSIKPQEKSEGLQLNFQQNVDDAMTVLPKLATGLDV 200 210 220 230 240 250 220 230 240 250 260 270 pF1KA1 NVRFTGVSDFEYTPECSVFDLLGIPLYHGWLVDPQSPEAVRAVGKLSYNQLVERIITCKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 NVRFTGVSDFEYTPECSVFDLLGIPLYHGWLVDPQSPEAVRAVGKLSYNQLVERIITCKH 260 270 280 290 300 310 280 290 300 310 320 330 pF1KA1 SSDTNLVTEGLIAEQFLETTAAQLTYHGLCELTAAAKEGELSVFFRNNHFSTMTKHKSHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 SSDTNLVTEGLIAEQFLETTAAQLTYHGLCELTAAAKEGELSVFFRNNHFSTMTKHKSHL 320 330 340 350 360 370 340 350 360 370 380 390 pF1KA1 YLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSLGKGPGAEGGSGSPEKQLQVD :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: CCDS53 YLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSLGKGPGAEGGSGSPETQLQVD 380 390 400 410 420 430 400 410 420 430 440 450 pF1KA1 QDYLIALSLQQQQPRGPLGLTDLELAQQLQQEEYQQQQAAQPVRMRTRVLSLQGRGATSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 QDYLIALSLQQQQPRGPLGLTDLELAQQLQQEEYQQQQAAQPVRMRTRVLSLQGRGATSG 440 450 460 470 480 490 460 pF1KA1 RPAGERRQRPKHESDCILL ::::::::::::::::::: CCDS53 RPAGERRQRPKHESDCILL 500 510 >>CCDS55635.1 FAM63A gene_id:55793|Hs108|chr1 (374 aa) initn: 2534 init1: 2534 opt: 2534 Z-score: 2205.5 bits: 417.1 E(32554): 1.6e-116 Smith-Waterman score: 2534; 99.7% identity (99.7% similar) in 374 aa overlap (96-469:1-374) 70 80 90 100 110 120 pF1KA1 LESPLPEASSAPPGPTLGTLPEVETIRACSMPQELPQSPRTRQPEPDFYCVKWIPWKGEQ :::::::::::::::::::::::::::::: CCDS55 MPQELPQSPRTRQPEPDFYCVKWIPWKGEQ 10 20 30 130 140 150 160 170 180 pF1KA1 TPIITQSTNGPCPLLAIMNILFLQWKVKLPPQKEVITSDELMAHLGNCLLSIKPQEKSEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 TPIITQSTNGPCPLLAIMNILFLQWKVKLPPQKEVITSDELMAHLGNCLLSIKPQEKSEG 40 50 60 70 80 90 190 200 210 220 230 240 pF1KA1 LQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLLGIPLYHGWLVDPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 LQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLLGIPLYHGWLVDPQ 100 110 120 130 140 150 250 260 270 280 290 300 pF1KA1 SPEAVRAVGKLSYNQLVERIITCKHSSDTNLVTEGLIAEQFLETTAAQLTYHGLCELTAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 SPEAVRAVGKLSYNQLVERIITCKHSSDTNLVTEGLIAEQFLETTAAQLTYHGLCELTAA 160 170 180 190 200 210 310 320 330 340 350 360 pF1KA1 AKEGELSVFFRNNHFSTMTKHKSHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 AKEGELSVFFRNNHFSTMTKHKSHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFH 220 230 240 250 260 270 370 380 390 400 410 420 pF1KA1 LSHSLGKGPGAEGGSGSPEKQLQVDQDYLIALSLQQQQPRGPLGLTDLELAQQLQQEEYQ ::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::: CCDS55 LSHSLGKGPGAEGGSGSPETQLQVDQDYLIALSLQQQQPRGPLGLTDLELAQQLQQEEYQ 280 290 300 310 320 330 430 440 450 460 pF1KA1 QQQAAQPVRMRTRVLSLQGRGATSGRPAGERRQRPKHESDCILL :::::::::::::::::::::::::::::::::::::::::::: CCDS55 QQQAAQPVRMRTRVLSLQGRGATSGRPAGERRQRPKHESDCILL 340 350 360 370 >>CCDS30854.1 FAM63A gene_id:55793|Hs108|chr1 (327 aa) initn: 2180 init1: 2180 opt: 2180 Z-score: 1899.8 bits: 360.3 E(32554): 1.7e-99 Smith-Waterman score: 2180; 99.7% identity (99.7% similar) in 327 aa overlap (143-469:1-327) 120 130 140 150 160 170 pF1KA1 FYCVKWIPWKGEQTPIITQSTNGPCPLLAIMNILFLQWKVKLPPQKEVITSDELMAHLGN :::::::::::::::::::::::::::::: CCDS30 MNILFLQWKVKLPPQKEVITSDELMAHLGN 10 20 30 180 190 200 210 220 230 pF1KA1 CLLSIKPQEKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 CLLSIKPQEKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLL 40 50 60 70 80 90 240 250 260 270 280 290 pF1KA1 GIPLYHGWLVDPQSPEAVRAVGKLSYNQLVERIITCKHSSDTNLVTEGLIAEQFLETTAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 GIPLYHGWLVDPQSPEAVRAVGKLSYNQLVERIITCKHSSDTNLVTEGLIAEQFLETTAA 100 110 120 130 140 150 300 310 320 330 340 350 pF1KA1 QLTYHGLCELTAAAKEGELSVFFRNNHFSTMTKHKSHLYLLVTDQGFLQEEQVVWESLHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 QLTYHGLCELTAAAKEGELSVFFRNNHFSTMTKHKSHLYLLVTDQGFLQEEQVVWESLHN 160 170 180 190 200 210 360 370 380 390 400 410 pF1KA1 VDGDSCFCDSDFHLSHSLGKGPGAEGGSGSPEKQLQVDQDYLIALSLQQQQPRGPLGLTD :::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::: CCDS30 VDGDSCFCDSDFHLSHSLGKGPGAEGGSGSPETQLQVDQDYLIALSLQQQQPRGPLGLTD 220 230 240 250 260 270 420 430 440 450 460 pF1KA1 LELAQQLQQEEYQQQQAAQPVRMRTRVLSLQGRGATSGRPAGERRQRPKHESDCILL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 LELAQQLQQEEYQQQQAAQPVRMRTRVLSLQGRGATSGRPAGERRQRPKHESDCILL 280 290 300 310 320 >>CCDS42046.1 FAM63B gene_id:54629|Hs108|chr15 (621 aa) initn: 1414 init1: 1253 opt: 1419 Z-score: 1236.3 bits: 238.5 E(32554): 1.5e-62 Smith-Waterman score: 1442; 54.5% identity (74.6% similar) in 433 aa overlap (58-465:185-608) 30 40 50 60 70 80 pF1KA1 LAGPDEHPQDTDARDADGEAREREPADQALLPSQCGDN----LESPLPEAS-SAPPGPTL .::.: : :. .:: .: : CCDS42 GGLSSSCSDPSPPGESPSLDSLESFSNLHSFPSSCEFNSEEGAENRVPEEEEGAAVLP-- 160 170 180 190 200 210 90 100 110 120 130 140 pF1KA1 GTLPEVETIRACSMPQELPQSPRTRQPEPDFYCVKWIPWKGEQTPIITQSTNGPCPLLAI :..: . .. : : : . : : . : .::: :: :.::::::. ::::::::: CCDS42 GAVPLCKEEEGEETAQVLAAS-KERFPGQSVYHIKWIQWKEENTPIITQNENGPCPLLAI 220 230 240 250 260 270 150 160 170 180 190 200 pF1KA1 MNILFLQWKVKLPPQKEVITSDELMAHLGNCLLSIKPQEKSEGLQLNFQQNVDDAMTVLP .:.:.: :::::::. :.::...:: .::. .:. ::.: :: .::..::..:::..: CCDS42 LNVLLLAWKVKLPPMMEIITAEQLMEYLGDYMLDAKPKEISEIQRLNYEQNMSDAMAILH 280 290 300 310 320 330 210 220 230 240 250 260 pF1KA1 KLATGLDVNVRFTGVSDFEYTPECSVFDLLGIPLYHGWLVDPQSPEAVRAVGKLSYNQLV :: :::::::::::: ::::::: ::::: :::::::::::: . :.:::. :::::: CCDS42 KLQTGLDVNVRFTGVRVFEYTPECIVFDLLDIPLYHGWLVDPQIDDIVKAVGNCSYNQLV 340 350 360 370 380 390 270 280 290 300 310 320 pF1KA1 ERIITCKHSSDTNLVTEGLIAEQFLETTAAQLTYHGLCELTAAAKEGELSVFFRNNHFST :.::.::.:....::.::..:::::..::.:::::::::::....:::: :::::::::: CCDS42 EKIISCKQSDNSELVSEGFVAEQFLNNTATQLTYHGLCELTSTVQEGELCVFFRNNHFST 400 410 420 430 440 450 330 340 350 360 370 380 pF1KA1 MTKHKSHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSLGKGPGAEGGSGS :::.:..::::::::::: ::.::::::::::::. ::::.::: : .. . CCDS42 MTKYKGQLYLLVTDQGFLTEEKVVWESLHNVDGDGNFCDSEFHLR------PPSDPETVY 460 470 480 490 500 390 400 410 420 pF1KA1 PEKQLQVDQDYLIALSLQQQQPRG-------PLGLTDLELAQQLQQEE-------YQQQQ .: :.:::::.::::::.: : :..:::::..::.:: ::.:. CCDS42 KGQQDQIDQDYLMALSLQQEQQSQEINWEQIPEGISDLELAKKLQEEEDRRASQYYQEQE 510 520 530 540 550 560 430 440 450 460 pF1KA1 AAQPVRMRTRVLSLQGRGA----TSGRPAG--ERRQRPKHESDCILL : . . . . ::. : .::: .: ::... .:.: CCDS42 QAAAAAAAASTQAQQGQPAQASPSSGRQSGNSERKRKEPREKDKEKEKEKNSCVIL 570 580 590 600 610 620 >>CCDS45268.1 FAM63B gene_id:54629|Hs108|chr15 (620 aa) initn: 1388 init1: 1253 opt: 1409 Z-score: 1227.7 bits: 236.9 E(32554): 4.6e-62 Smith-Waterman score: 1432; 54.4% identity (74.1% similar) in 432 aa overlap (58-465:185-607) 30 40 50 60 70 80 pF1KA1 LAGPDEHPQDTDARDADGEAREREPADQALLPSQCGDN----LESPLPEAS-SAPPGPTL .::.: : :. .:: .: : CCDS45 GGLSSSCSDPSPPGESPSLDSLESFSNLHSFPSSCEFNSEEGAENRVPEEEEGAAVLP-- 160 170 180 190 200 210 90 100 110 120 130 140 pF1KA1 GTLPEVETIRACSMPQELPQSPRTRQPEPDFYCVKWIPWKGEQTPIITQSTNGPCPLLAI :..: . .. : : : . : : . : .::: :: :.::::::. ::::::::: CCDS45 GAVPLCKEEEGEETAQVLAAS-KERFPGQSVYHIKWIQWKEENTPIITQNENGPCPLLAI 220 230 240 250 260 270 150 160 170 180 190 200 pF1KA1 MNILFLQWKVKLPPQKEVITSDELMAHLGNCLLSIKPQEKSEGLQLNFQQNVDDAMTVLP .:.:.: :::::::. :.::...:: .::. .:. ::.: :: .::..::..:::..: CCDS45 LNVLLLAWKVKLPPMMEIITAEQLMEYLGDYMLDAKPKEISEIQRLNYEQNMSDAMAILH 280 290 300 310 320 330 210 220 230 240 250 260 pF1KA1 KLATGLDVNVRFTGVSDFEYTPECSVFDLLGIPLYHGWLVDPQSPEAVRAVGKLSYNQLV :: :::::::::::: ::::::: ::::: :::::::::::: . :.:::. :::::: CCDS45 KLQTGLDVNVRFTGVRVFEYTPECIVFDLLDIPLYHGWLVDPQIDDIVKAVGNCSYNQLV 340 350 360 370 380 390 270 280 290 300 310 320 pF1KA1 ERIITCKHSSDTNLVTEGLIAEQFLETTAAQLTYHGLCELTAAAKEGELSVFFRNNHFST :.::.::.:....::.::..:::::..::.:::::::::::....:::: :::::::::: CCDS45 EKIISCKQSDNSELVSEGFVAEQFLNNTATQLTYHGLCELTSTVQEGELCVFFRNNHFST 400 410 420 430 440 450 330 340 350 360 370 380 pF1KA1 MTKHKSHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSLGKGPGAEGGSGS :::.:..::::::::::: ::.::::::::::::. ::::.::: : .. . CCDS45 MTKYKGQLYLLVTDQGFLTEEKVVWESLHNVDGDGNFCDSEFHLR------PPSDPETVY 460 470 480 490 500 390 400 410 420 pF1KA1 PEKQLQVDQDYLIALSLQQQQPRG-------PLGLTDLELAQQLQQEE------YQQQQA .: :.:::::.::::::.: : :..:::::..::.:: : :.: CCDS45 KGQQDQIDQDYLMALSLQQEQQSQEINWEQIPEGISDLELAKKLQEEEDRRASQYYQEQE 510 520 530 540 550 560 430 440 450 460 pF1KA1 AQPVRMRTRVLSLQGRGA----TSGRPAG--ERRQRPKHESDCILL . . . ::. : .::: .: ::... .:.: CCDS45 QAAAAAAAASTQAQGQPAQASPSSGRQSGNSERKRKEPREKDKEKEKEKNSCVIL 570 580 590 600 610 620 469 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 21:08:13 2016 done: Wed Nov 2 21:08:14 2016 Total Scan time: 3.420 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]