FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1464, 620 aa 1>>>pF1KA1464 620 - 620 aa - 620 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.4433+/-0.000354; mu= -4.6970+/- 0.022 mean_var=231.0128+/-46.734, 0's: 0 Z-trim(121.7): 37 B-trim: 100 in 1/58 Lambda= 0.084383 statistics sampled from 38697 (38743) to 38697 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.759), E-opt: 0.2 (0.454), width: 16 Scan time: 13.030 The best scores are: opt bits E(85289) NP_065901 (OMIM: 614031) ran-binding protein 10 is ( 620) 4229 527.8 4.4e-149 XP_005256127 (OMIM: 614031) PREDICTED: ran-binding ( 650) 3099 390.2 1.2e-107 XP_016878996 (OMIM: 614031) PREDICTED: ran-binding ( 436) 2824 356.7 1e-97 NP_005484 (OMIM: 603854) ran-binding protein 9 [Ho ( 729) 2815 355.6 3.4e-97 NP_001307169 (OMIM: 614031) ran-binding protein 10 ( 391) 2604 329.9 1e-89 XP_016878998 (OMIM: 614031) PREDICTED: ran-binding ( 391) 2604 329.9 1e-89 NP_001307167 (OMIM: 614031) ran-binding protein 10 ( 533) 2282 290.7 8.7e-78 XP_016865638 (OMIM: 603854) PREDICTED: ran-binding ( 507) 2265 288.6 3.5e-77 XP_006715008 (OMIM: 603854) PREDICTED: ran-binding ( 500) 2247 286.4 1.6e-76 XP_005256129 (OMIM: 614031) PREDICTED: ran-binding ( 518) 2176 277.8 6.5e-74 XP_011512507 (OMIM: 603854) PREDICTED: ran-binding ( 639) 2058 263.5 1.7e-69 NP_001307168 (OMIM: 614031) ran-binding protein 10 ( 594) 1748 225.7 3.6e-58 XP_016878997 (OMIM: 614031) PREDICTED: ran-binding ( 421) 1474 192.3 2.9e-48 XP_011521549 (OMIM: 614031) PREDICTED: ran-binding ( 421) 1474 192.3 2.9e-48 XP_011521547 (OMIM: 614031) PREDICTED: ran-binding ( 391) 1258 166.0 2.2e-40 XP_006721301 (OMIM: 614031) PREDICTED: ran-binding ( 494) 1260 166.3 2.3e-40 >>NP_065901 (OMIM: 614031) ran-binding protein 10 isofor (620 aa) initn: 4229 init1: 4229 opt: 4229 Z-score: 2797.5 bits: 527.8 E(85289): 4.4e-149 Smith-Waterman score: 4229; 100.0% identity (100.0% similar) in 620 aa overlap (1-620:1-620) 10 20 30 40 50 60 pF1KA1 MAAATADPGAGNPQPGDSSGGGAGGGLPSPGEQELSRRLQRLYPAVNQQETPLPRSWSPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MAAATADPGAGNPQPGDSSGGGAGGGLPSPGEQELSRRLQRLYPAVNQQETPLPRSWSPK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 DKYNYIGLSQGNLRVHYKGHGKNHKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 DKYNYIGLSQGNLRVHYKGHGKNHKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 GLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINGTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINGTC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 FYTKNGHSLGIAFTDLPANLYPTVGLQTPGEIVDANFGQQPFLFDIEDYMREWRAKVQGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 FYTKNGHSLGIAFTDLPANLYPTVGLQTPGEIVDANFGQQPFLFDIEDYMREWRAKVQGT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 VHCFPISARLGEWQAVLQNMVSSYLVHHGYCATATAFARMTETPIQEEQASIKNRQKIQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 VHCFPISARLGEWQAVLQNMVSSYLVHHGYCATATAFARMTETPIQEEQASIKNRQKIQK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 LVLEGRVGEAIETTQRFYPGLLEHNPNLLFMLKCRQFVEMVNGTDSEVRSLSSRSPKSQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LVLEGRVGEAIETTQRFYPGLLEHNPNLLFMLKCRQFVEMVNGTDSEVRSLSSRSPKSQD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 SYPGSPSLSPRHGPSSSHMHNTGADSPSCSNGVASTKSKQNHSKYPAPSSSSSSSSSSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SYPGSPSLSPRHGPSSSHMHNTGADSPSCSNGVASTKSKQNHSKYPAPSSSSSSSSSSSS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 SSPSSVNYSESNSTDSTKSQHHSSTSNQETSDSEMEMEAEHYPNGVLGSMSTRIVNGAYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SSPSSVNYSESNSTDSTKSQHHSSTSNQETSDSEMEMEAEHYPNGVLGSMSTRIVNGAYK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 HEDLQTDESSMDDRHPRRQLCGGNQAATERIILFGRELQALSEQLGREYGKNLAHTEMLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 HEDLQTDESSMDDRHPRRQLCGGNQAATERIILFGRELQALSEQLGREYGKNLAHTEMLQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 DAFSLLAYSDPWSCPVGQQLDPIQREPVCAALNSAILESQNLPKQPPLMLALGQASECLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 DAFSLLAYSDPWSCPVGQQLDPIQREPVCAALNSAILESQNLPKQPPLMLALGQASECLR 550 560 570 580 590 600 610 620 pF1KA1 LMARAGLGSCSFARVDDYLH :::::::::::::::::::: NP_065 LMARAGLGSCSFARVDDYLH 610 620 >>XP_005256127 (OMIM: 614031) PREDICTED: ran-binding pro (650 aa) initn: 3171 init1: 3097 opt: 3099 Z-score: 2053.7 bits: 390.2 E(85289): 1.2e-107 Smith-Waterman score: 4159; 95.4% identity (95.4% similar) in 650 aa overlap (1-620:1-650) 10 20 30 40 50 60 pF1KA1 MAAATADPGAGNPQPGDSSGGGAGGGLPSPGEQELSRRLQRLYPAVNQQETPLPRSWSPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAAATADPGAGNPQPGDSSGGGAGGGLPSPGEQELSRRLQRLYPAVNQQETPLPRSWSPK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 DKYNYIGLSQGNLRVHYKGHGKNHKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DKYNYIGLSQGNLRVHYKGHGKNHKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 GLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINGTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINGTC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 FYTKNGHSLGIAFTDLPANLYPTVGLQTPGEIVDANFGQQPFLFDIEDYMREWRAKVQGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FYTKNGHSLGIAFTDLPANLYPTVGLQTPGEIVDANFGQQPFLFDIEDYMREWRAKVQGT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 VHCFPISARLGEWQAVLQNMVSSYLVHHGYCATATAFARMTETPIQEEQASIKNRQKIQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VHCFPISARLGEWQAVLQNMVSSYLVHHGYCATATAFARMTETPIQEEQASIKNRQKIQK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 LVLEGRVGEAIETTQRFYPGLLEHNPNLLFMLKCRQFVEMVNGTDSEVRSLSSRSPKSQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LVLEGRVGEAIETTQRFYPGLLEHNPNLLFMLKCRQFVEMVNGTDSEVRSLSSRSPKSQD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 SYPGSPSLSPRHGPSSSHMHNTGADSPSCSNGVASTKSKQNHSKYPAPSSSSSSSSSSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SYPGSPSLSPRHGPSSSHMHNTGADSPSCSNGVASTKSKQNHSKYPAPSSSSSSSSSSSS 370 380 390 400 410 420 430 440 450 pF1KA1 SSPSSVNYSESNSTDSTKSQHHSSTSNQETS----------------------------- ::::::::::::::::::::::::::::::: XP_005 SSPSSVNYSESNSTDSTKSQHHSSTSNQETSNPWLQLERRPNQAAPTTPPGPTPTSTPPH 430 440 450 460 470 480 460 470 480 490 500 510 pF1KA1 -DSEMEMEAEHYPNGVLGSMSTRIVNGAYKHEDLQTDESSMDDRHPRRQLCGGNQAATER ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDSEMEMEAEHYPNGVLGSMSTRIVNGAYKHEDLQTDESSMDDRHPRRQLCGGNQAATER 490 500 510 520 530 540 520 530 540 550 560 570 pF1KA1 IILFGRELQALSEQLGREYGKNLAHTEMLQDAFSLLAYSDPWSCPVGQQLDPIQREPVCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IILFGRELQALSEQLGREYGKNLAHTEMLQDAFSLLAYSDPWSCPVGQQLDPIQREPVCA 550 560 570 580 590 600 580 590 600 610 620 pF1KA1 ALNSAILESQNLPKQPPLMLALGQASECLRLMARAGLGSCSFARVDDYLH :::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALNSAILESQNLPKQPPLMLALGQASECLRLMARAGLGSCSFARVDDYLH 610 620 630 640 650 >>XP_016878996 (OMIM: 614031) PREDICTED: ran-binding pro (436 aa) initn: 2824 init1: 2824 opt: 2824 Z-score: 1875.5 bits: 356.7 E(85289): 1e-97 Smith-Waterman score: 2824; 100.0% identity (100.0% similar) in 423 aa overlap (198-620:14-436) 170 180 190 200 210 220 pF1KA1 VIGCCVNLINGTCFYTKNGHSLGIAFTDLPANLYPTVGLQTPGEIVDANFGQQPFLFDIE :::::::::::::::::::::::::::::: XP_016 MAPASTPRMATALANLYPTVGLQTPGEIVDANFGQQPFLFDIE 10 20 30 40 230 240 250 260 270 280 pF1KA1 DYMREWRAKVQGTVHCFPISARLGEWQAVLQNMVSSYLVHHGYCATATAFARMTETPIQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DYMREWRAKVQGTVHCFPISARLGEWQAVLQNMVSSYLVHHGYCATATAFARMTETPIQE 50 60 70 80 90 100 290 300 310 320 330 340 pF1KA1 EQASIKNRQKIQKLVLEGRVGEAIETTQRFYPGLLEHNPNLLFMLKCRQFVEMVNGTDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQASIKNRQKIQKLVLEGRVGEAIETTQRFYPGLLEHNPNLLFMLKCRQFVEMVNGTDSE 110 120 130 140 150 160 350 360 370 380 390 400 pF1KA1 VRSLSSRSPKSQDSYPGSPSLSPRHGPSSSHMHNTGADSPSCSNGVASTKSKQNHSKYPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VRSLSSRSPKSQDSYPGSPSLSPRHGPSSSHMHNTGADSPSCSNGVASTKSKQNHSKYPA 170 180 190 200 210 220 410 420 430 440 450 460 pF1KA1 PSSSSSSSSSSSSSSPSSVNYSESNSTDSTKSQHHSSTSNQETSDSEMEMEAEHYPNGVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSSSSSSSSSSSSSSPSSVNYSESNSTDSTKSQHHSSTSNQETSDSEMEMEAEHYPNGVL 230 240 250 260 270 280 470 480 490 500 510 520 pF1KA1 GSMSTRIVNGAYKHEDLQTDESSMDDRHPRRQLCGGNQAATERIILFGRELQALSEQLGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSMSTRIVNGAYKHEDLQTDESSMDDRHPRRQLCGGNQAATERIILFGRELQALSEQLGR 290 300 310 320 330 340 530 540 550 560 570 580 pF1KA1 EYGKNLAHTEMLQDAFSLLAYSDPWSCPVGQQLDPIQREPVCAALNSAILESQNLPKQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EYGKNLAHTEMLQDAFSLLAYSDPWSCPVGQQLDPIQREPVCAALNSAILESQNLPKQPP 350 360 370 380 390 400 590 600 610 620 pF1KA1 LMLALGQASECLRLMARAGLGSCSFARVDDYLH ::::::::::::::::::::::::::::::::: XP_016 LMLALGQASECLRLMARAGLGSCSFARVDDYLH 410 420 430 >>NP_005484 (OMIM: 603854) ran-binding protein 9 [Homo s (729 aa) initn: 2826 init1: 2002 opt: 2815 Z-score: 1866.0 bits: 355.6 E(85289): 3.4e-97 Smith-Waterman score: 2835; 66.3% identity (81.2% similar) in 658 aa overlap (3-620:93-729) 10 20 30 pF1KA1 MAAATADPGAGNPQP-GDSSGGGAGGGLPSPG :..: :..: : : : ..: : .:: :.:. NP_005 AAAALLLHPPPPPPPATAAPPPPPPPPPPPASAAAPASGPPAPPGLAAGPGPAGGAPTPA 70 80 90 100 110 120 40 50 60 70 pF1KA1 ---------------------EQELSRRLQRLYPAVNQQETPLPRSWSPKDKYNYIGLSQ :.::.:::.::::::..::::::::::::::..:::::: NP_005 LVAGSSAAAPFPHGDSALNEQEKELQRRLKRLYPAVDEQETPLPRSWSPKDKFSYIGLSQ 130 140 150 160 170 180 80 90 100 110 120 130 pF1KA1 GNLRVHYKGHGKNHKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVNMN .:::::::::::. :::::::::::::::::::::::::::::::::::::::::::::: NP_005 NNLRVHYKGHGKTPKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVNMN 190 200 210 220 230 240 140 150 160 170 180 190 pF1KA1 RLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINGTCFYTKNGHSLG :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: NP_005 RLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINNTCFYTKNGHSLG 250 260 270 280 290 300 200 210 220 230 240 250 pF1KA1 IAFTDLPANLYPTVGLQTPGEIVDANFGQQPFLFDIEDYMREWRAKVQGTVHCFPISARL ::::::: :::::::::::::.:::::::.::.:::::::::::.:.:. . :::. : NP_005 IAFTDLPPNLYPTVGLQTPGEVVDANFGQHPFVFDIEDYMREWRTKIQAQIDRFPIGDRE 310 320 330 340 350 360 260 270 280 290 300 310 pF1KA1 GEWQAVLQNMVSSYLVHHGYCATATAFARMTETPIQEEQASIKNRQKIQKLVLEGRVGEA ::::...:.::::::::::::::: :::: :. . :: :::::::.:::::: ::.::: NP_005 GEWQTMIQKMVSSYLVHHGYCATAEAFARSTDQTVLEELASIKNRQRIQKLVLAGRMGEA 370 380 390 400 410 420 320 330 340 350 360 pF1KA1 IETTQRFYPGLLEHNPNLLFMLKCRQFVEMVNGTDSEVRSLSSRSPKSQDSYP------G :::::..::.:::.:::::: :: :::.::::::::::: :..:::::::::: . NP_005 IETTQQLYPSLLERNPNLLFTLKVRQFIEMVNGTDSEVRCLGGRSPKSQDSYPVSPRPFS 430 440 450 460 470 480 370 380 390 400 410 pF1KA1 SPSLSPRHGPSSSHMHN--TGADSP-------SCSNGVASTKSKQNHSKYPAPSSSSSSS :::.:: :: ..:: .: : :::::: :.:..:.. . NP_005 SPSMSPSHG---MNIHNLASGKGSTAHFSGFESCSNGVISNKAHQSYCH----------- 490 500 510 520 420 430 440 450 460 470 pF1KA1 SSSSSSSPSSVNYSESNSTDSTKSQHHSSTSNQETSDSEMEMEAEHYPNGVLGSMSTRIV :.. . :..: : :: . ..::. :. ::. ...::..:: ::: . :. .. NP_005 --SNKHQSSNLNVPELNSINMSRSQQ----VNNFTSN-DVDMETDHYSNGVGETSSNGFL 530 540 550 560 570 580 480 490 500 510 520 530 pF1KA1 NGAYKHEDLQTD---ESSMDDRHPRRQLCGGNQAATERIILFGRELQALSEQLGREYGKN ::. ::. . : : .:. . :::::::.::: ::.: :::::::.:::: :. ::: NP_005 NGSSKHDHEMEDCDTEMEVDSSQLRRQLCGGSQAAIERMIHFGRELQAMSEQLRRDCGKN 590 600 610 620 630 640 540 550 560 570 580 590 pF1KA1 LAHTEMLQDAFSLLAYSDPWSCPVGQQLDPIQREPVCAALNSAILESQNLPKQPPLMLAL :. .::.::::::::::::. :::.:::::::::::.::::::::..:::::::: ::. NP_005 TANKKMLKDAFSLLAYSDPWNSPVGNQLDPIQREPVCSALNSAILETHNLPKQPPLALAM 650 660 670 680 690 700 600 610 620 pF1KA1 GQASECLRLMARAGLGSCSFARVDDYLH :::..:: ::::.:.:::.:: :.:::: NP_005 GQATQCLGLMARSGIGSCAFATVEDYLH 710 720 >>NP_001307169 (OMIM: 614031) ran-binding protein 10 iso (391 aa) initn: 2604 init1: 2604 opt: 2604 Z-score: 1731.5 bits: 329.9 E(85289): 1e-89 Smith-Waterman score: 2604; 100.0% identity (100.0% similar) in 391 aa overlap (230-620:1-391) 200 210 220 230 240 250 pF1KA1 LYPTVGLQTPGEIVDANFGQQPFLFDIEDYMREWRAKVQGTVHCFPISARLGEWQAVLQN :::::::::::::::::::::::::::::: NP_001 MREWRAKVQGTVHCFPISARLGEWQAVLQN 10 20 30 260 270 280 290 300 310 pF1KA1 MVSSYLVHHGYCATATAFARMTETPIQEEQASIKNRQKIQKLVLEGRVGEAIETTQRFYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVSSYLVHHGYCATATAFARMTETPIQEEQASIKNRQKIQKLVLEGRVGEAIETTQRFYP 40 50 60 70 80 90 320 330 340 350 360 370 pF1KA1 GLLEHNPNLLFMLKCRQFVEMVNGTDSEVRSLSSRSPKSQDSYPGSPSLSPRHGPSSSHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLLEHNPNLLFMLKCRQFVEMVNGTDSEVRSLSSRSPKSQDSYPGSPSLSPRHGPSSSHM 100 110 120 130 140 150 380 390 400 410 420 430 pF1KA1 HNTGADSPSCSNGVASTKSKQNHSKYPAPSSSSSSSSSSSSSSPSSVNYSESNSTDSTKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HNTGADSPSCSNGVASTKSKQNHSKYPAPSSSSSSSSSSSSSSPSSVNYSESNSTDSTKS 160 170 180 190 200 210 440 450 460 470 480 490 pF1KA1 QHHSSTSNQETSDSEMEMEAEHYPNGVLGSMSTRIVNGAYKHEDLQTDESSMDDRHPRRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QHHSSTSNQETSDSEMEMEAEHYPNGVLGSMSTRIVNGAYKHEDLQTDESSMDDRHPRRQ 220 230 240 250 260 270 500 510 520 530 540 550 pF1KA1 LCGGNQAATERIILFGRELQALSEQLGREYGKNLAHTEMLQDAFSLLAYSDPWSCPVGQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCGGNQAATERIILFGRELQALSEQLGREYGKNLAHTEMLQDAFSLLAYSDPWSCPVGQQ 280 290 300 310 320 330 560 570 580 590 600 610 pF1KA1 LDPIQREPVCAALNSAILESQNLPKQPPLMLALGQASECLRLMARAGLGSCSFARVDDYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDPIQREPVCAALNSAILESQNLPKQPPLMLALGQASECLRLMARAGLGSCSFARVDDYL 340 350 360 370 380 390 620 pF1KA1 H : NP_001 H >>XP_016878998 (OMIM: 614031) PREDICTED: ran-binding pro (391 aa) initn: 2604 init1: 2604 opt: 2604 Z-score: 1731.5 bits: 329.9 E(85289): 1e-89 Smith-Waterman score: 2604; 100.0% identity (100.0% similar) in 391 aa overlap (230-620:1-391) 200 210 220 230 240 250 pF1KA1 LYPTVGLQTPGEIVDANFGQQPFLFDIEDYMREWRAKVQGTVHCFPISARLGEWQAVLQN :::::::::::::::::::::::::::::: XP_016 MREWRAKVQGTVHCFPISARLGEWQAVLQN 10 20 30 260 270 280 290 300 310 pF1KA1 MVSSYLVHHGYCATATAFARMTETPIQEEQASIKNRQKIQKLVLEGRVGEAIETTQRFYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVSSYLVHHGYCATATAFARMTETPIQEEQASIKNRQKIQKLVLEGRVGEAIETTQRFYP 40 50 60 70 80 90 320 330 340 350 360 370 pF1KA1 GLLEHNPNLLFMLKCRQFVEMVNGTDSEVRSLSSRSPKSQDSYPGSPSLSPRHGPSSSHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLLEHNPNLLFMLKCRQFVEMVNGTDSEVRSLSSRSPKSQDSYPGSPSLSPRHGPSSSHM 100 110 120 130 140 150 380 390 400 410 420 430 pF1KA1 HNTGADSPSCSNGVASTKSKQNHSKYPAPSSSSSSSSSSSSSSPSSVNYSESNSTDSTKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HNTGADSPSCSNGVASTKSKQNHSKYPAPSSSSSSSSSSSSSSPSSVNYSESNSTDSTKS 160 170 180 190 200 210 440 450 460 470 480 490 pF1KA1 QHHSSTSNQETSDSEMEMEAEHYPNGVLGSMSTRIVNGAYKHEDLQTDESSMDDRHPRRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QHHSSTSNQETSDSEMEMEAEHYPNGVLGSMSTRIVNGAYKHEDLQTDESSMDDRHPRRQ 220 230 240 250 260 270 500 510 520 530 540 550 pF1KA1 LCGGNQAATERIILFGRELQALSEQLGREYGKNLAHTEMLQDAFSLLAYSDPWSCPVGQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCGGNQAATERIILFGRELQALSEQLGREYGKNLAHTEMLQDAFSLLAYSDPWSCPVGQQ 280 290 300 310 320 330 560 570 580 590 600 610 pF1KA1 LDPIQREPVCAALNSAILESQNLPKQPPLMLALGQASECLRLMARAGLGSCSFARVDDYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDPIQREPVCAALNSAILESQNLPKQPPLMLALGQASECLRLMARAGLGSCSFARVDDYL 340 350 360 370 380 390 620 pF1KA1 H : XP_016 H >>NP_001307167 (OMIM: 614031) ran-binding protein 10 iso (533 aa) initn: 2354 init1: 2280 opt: 2282 Z-score: 1517.5 bits: 290.7 E(85289): 8.7e-78 Smith-Waterman score: 3342; 94.4% identity (94.4% similar) in 533 aa overlap (118-620:1-533) 90 100 110 120 130 140 pF1KA1 ASVRATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDG :::::::::::::::::::::::::::::: NP_001 MGIGLSAQGVNMNRLPGWDKHSYGYHGDDG 10 20 30 150 160 170 180 190 200 pF1KA1 HSFCSSGTGQPYGPTFTTGDVIGCCVNLINGTCFYTKNGHSLGIAFTDLPANLYPTVGLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HSFCSSGTGQPYGPTFTTGDVIGCCVNLINGTCFYTKNGHSLGIAFTDLPANLYPTVGLQ 40 50 60 70 80 90 210 220 230 240 250 260 pF1KA1 TPGEIVDANFGQQPFLFDIEDYMREWRAKVQGTVHCFPISARLGEWQAVLQNMVSSYLVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPGEIVDANFGQQPFLFDIEDYMREWRAKVQGTVHCFPISARLGEWQAVLQNMVSSYLVH 100 110 120 130 140 150 270 280 290 300 310 320 pF1KA1 HGYCATATAFARMTETPIQEEQASIKNRQKIQKLVLEGRVGEAIETTQRFYPGLLEHNPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HGYCATATAFARMTETPIQEEQASIKNRQKIQKLVLEGRVGEAIETTQRFYPGLLEHNPN 160 170 180 190 200 210 330 340 350 360 370 380 pF1KA1 LLFMLKCRQFVEMVNGTDSEVRSLSSRSPKSQDSYPGSPSLSPRHGPSSSHMHNTGADSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLFMLKCRQFVEMVNGTDSEVRSLSSRSPKSQDSYPGSPSLSPRHGPSSSHMHNTGADSP 220 230 240 250 260 270 390 400 410 420 430 440 pF1KA1 SCSNGVASTKSKQNHSKYPAPSSSSSSSSSSSSSSPSSVNYSESNSTDSTKSQHHSSTSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCSNGVASTKSKQNHSKYPAPSSSSSSSSSSSSSSPSSVNYSESNSTDSTKSQHHSSTSN 280 290 300 310 320 330 450 460 470 pF1KA1 QETS------------------------------DSEMEMEAEHYPNGVLGSMSTRIVNG :::: :::::::::::::::::::::::::: NP_001 QETSNPWLQLERRPNQAAPTTPPGPTPTSTPPHSDSEMEMEAEHYPNGVLGSMSTRIVNG 340 350 360 370 380 390 480 490 500 510 520 530 pF1KA1 AYKHEDLQTDESSMDDRHPRRQLCGGNQAATERIILFGRELQALSEQLGREYGKNLAHTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AYKHEDLQTDESSMDDRHPRRQLCGGNQAATERIILFGRELQALSEQLGREYGKNLAHTE 400 410 420 430 440 450 540 550 560 570 580 590 pF1KA1 MLQDAFSLLAYSDPWSCPVGQQLDPIQREPVCAALNSAILESQNLPKQPPLMLALGQASE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLQDAFSLLAYSDPWSCPVGQQLDPIQREPVCAALNSAILESQNLPKQPPLMLALGQASE 460 470 480 490 500 510 600 610 620 pF1KA1 CLRLMARAGLGSCSFARVDDYLH ::::::::::::::::::::::: NP_001 CLRLMARAGLGSCSFARVDDYLH 520 530 >>XP_016865638 (OMIM: 603854) PREDICTED: ran-binding pro (507 aa) initn: 2267 init1: 1487 opt: 2265 Z-score: 1506.7 bits: 288.6 E(85289): 3.5e-77 Smith-Waterman score: 2284; 66.5% identity (81.9% similar) in 525 aa overlap (114-620:4-507) 90 100 110 120 130 140 pF1KA1 HKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYH . :::::::::::::::::::::::::::: XP_016 MDHKKGYMGIGLSAQGVNMNRLPGWDKHSYGYH 10 20 30 150 160 170 180 190 200 pF1KA1 GDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINGTCFYTKNGHSLGIAFTDLPANLYPT ::::::::::::::::::::::::::::::::::.::::::::::::::::::: ::::: XP_016 GDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINNTCFYTKNGHSLGIAFTDLPPNLYPT 40 50 60 70 80 90 210 220 230 240 250 260 pF1KA1 VGLQTPGEIVDANFGQQPFLFDIEDYMREWRAKVQGTVHCFPISARLGEWQAVLQNMVSS ::::::::.:::::::.::.:::::::::::.:.:. . :::. : ::::...:.:::: XP_016 VGLQTPGEVVDANFGQHPFVFDIEDYMREWRTKIQAQIDRFPIGDREGEWQTMIQKMVSS 100 110 120 130 140 150 270 280 290 300 310 320 pF1KA1 YLVHHGYCATATAFARMTETPIQEEQASIKNRQKIQKLVLEGRVGEAIETTQRFYPGLLE ::::::::::: :::: :. . :: :::::::.:::::: ::.::::::::..::.::: XP_016 YLVHHGYCATAEAFARSTDQTVLEELASIKNRQRIQKLVLAGRMGEAIETTQQLYPSLLE 160 170 180 190 200 210 330 340 350 360 370 pF1KA1 HNPNLLFMLKCRQFVEMVNGTDSEVRSLSSRSPKSQDSYP------GSPSLSPRHGPSSS .:::::: :: :::.::::::::::: :..:::::::::: .:::.:: :: XP_016 RNPNLLFTLKVRQFIEMVNGTDSEVRCLGGRSPKSQDSYPVSPRPFSSPSMSPSHG---M 220 230 240 250 260 270 380 390 400 410 420 pF1KA1 HMHN--TGADSP-------SCSNGVASTKSKQNHSKYPAPSSSSSSSSSSSSSSPSSVNY ..:: .: : :::::: :.:..:.. . :.. . :..: XP_016 NIHNLASGKGSTAHFSGFESCSNGVISNKAHQSYCH-------------SNKHQSSNLNV 280 290 300 310 430 440 450 460 470 480 pF1KA1 SESNSTDSTKSQHHSSTSNQETSDSEMEMEAEHYPNGVLGSMSTRIVNGAYKHEDLQTD- : :: . ..::. :. ::. ...::..:: ::: . :. ..::. ::. . : XP_016 PELNSINMSRSQQ----VNNFTSN-DVDMETDHYSNGVGETSSNGFLNGSSKHDHEMEDC 320 330 340 350 360 370 490 500 510 520 530 540 pF1KA1 --ESSMDDRHPRRQLCGGNQAATERIILFGRELQALSEQLGREYGKNLAHTEMLQDAFSL : .:. . :::::::.::: ::.: :::::::.:::: :. ::: :. .::.::::: XP_016 DTEMEVDSSQLRRQLCGGSQAAIERMIHFGRELQAMSEQLRRDCGKNTANKKMLKDAFSL 380 390 400 410 420 430 550 560 570 580 590 600 pF1KA1 LAYSDPWSCPVGQQLDPIQREPVCAALNSAILESQNLPKQPPLMLALGQASECLRLMARA :::::::. :::.:::::::::::.::::::::..:::::::: ::.:::..:: ::::. XP_016 LAYSDPWNSPVGNQLDPIQREPVCSALNSAILETHNLPKQPPLALAMGQATQCLGLMARS 440 450 460 470 480 490 610 620 pF1KA1 GLGSCSFARVDDYLH :.:::.:: :.:::: XP_016 GIGSCAFATVEDYLH 500 >>XP_006715008 (OMIM: 603854) PREDICTED: ran-binding pro (500 aa) initn: 2249 init1: 1469 opt: 2247 Z-score: 1494.9 bits: 286.4 E(85289): 1.6e-76 Smith-Waterman score: 2266; 66.7% identity (81.9% similar) in 519 aa overlap (118-620:1-500) 90 100 110 120 130 140 pF1KA1 ASVRATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDG :::::::::::::::::::::::::::::: XP_006 MGIGLSAQGVNMNRLPGWDKHSYGYHGDDG 10 20 30 150 160 170 180 190 200 pF1KA1 HSFCSSGTGQPYGPTFTTGDVIGCCVNLINGTCFYTKNGHSLGIAFTDLPANLYPTVGLQ ::::::::::::::::::::::::::::::.::::::::::::::::::: ::::::::: XP_006 HSFCSSGTGQPYGPTFTTGDVIGCCVNLINNTCFYTKNGHSLGIAFTDLPPNLYPTVGLQ 40 50 60 70 80 90 210 220 230 240 250 260 pF1KA1 TPGEIVDANFGQQPFLFDIEDYMREWRAKVQGTVHCFPISARLGEWQAVLQNMVSSYLVH ::::.:::::::.::.:::::::::::.:.:. . :::. : ::::...:.:::::::: XP_006 TPGEVVDANFGQHPFVFDIEDYMREWRTKIQAQIDRFPIGDREGEWQTMIQKMVSSYLVH 100 110 120 130 140 150 270 280 290 300 310 320 pF1KA1 HGYCATATAFARMTETPIQEEQASIKNRQKIQKLVLEGRVGEAIETTQRFYPGLLEHNPN ::::::: :::: :. . :: :::::::.:::::: ::.::::::::..::.:::.::: XP_006 HGYCATAEAFARSTDQTVLEELASIKNRQRIQKLVLAGRMGEAIETTQQLYPSLLERNPN 160 170 180 190 200 210 330 340 350 360 370 380 pF1KA1 LLFMLKCRQFVEMVNGTDSEVRSLSSRSPKSQDSYP------GSPSLSPRHGPSSSHMHN ::: :: :::.::::::::::: :..:::::::::: .:::.:: :: . : XP_006 LLFTLKVRQFIEMVNGTDSEVRCLGGRSPKSQDSYPVSPRPFSSPSMSPSHG-MNIHNLA 220 230 240 250 260 390 400 410 420 430 pF1KA1 TGADSP-------SCSNGVASTKSKQNHSKYPAPSSSSSSSSSSSSSSPSSVNYSESNST .: : :::::: :.:..:.. . :.. . :..: : :: XP_006 SGKGSTAHFSGFESCSNGVISNKAHQSYCH-------------SNKHQSSNLNVPELNSI 270 280 290 300 310 440 450 460 470 480 490 pF1KA1 DSTKSQHHSSTSNQETSDSEMEMEAEHYPNGVLGSMSTRIVNGAYKHEDLQTD---ESSM . ..::. :. ::. ...::..:: ::: . :. ..::. ::. . : : . XP_006 NMSRSQQ----VNNFTSN-DVDMETDHYSNGVGETSSNGFLNGSSKHDHEMEDCDTEMEV 320 330 340 350 360 370 500 510 520 530 540 550 pF1KA1 DDRHPRRQLCGGNQAATERIILFGRELQALSEQLGREYGKNLAHTEMLQDAFSLLAYSDP :. . :::::::.::: ::.: :::::::.:::: :. ::: :. .::.::::::::::: XP_006 DSSQLRRQLCGGSQAAIERMIHFGRELQAMSEQLRRDCGKNTANKKMLKDAFSLLAYSDP 380 390 400 410 420 430 560 570 580 590 600 610 pF1KA1 WSCPVGQQLDPIQREPVCAALNSAILESQNLPKQPPLMLALGQASECLRLMARAGLGSCS :. :::.:::::::::::.::::::::..:::::::: ::.:::..:: ::::.:.:::. XP_006 WNSPVGNQLDPIQREPVCSALNSAILETHNLPKQPPLALAMGQATQCLGLMARSGIGSCA 440 450 460 470 480 490 620 pF1KA1 FARVDDYLH :: :.:::: XP_006 FATVEDYLH 500 >>XP_005256129 (OMIM: 614031) PREDICTED: ran-binding pro (518 aa) initn: 2248 init1: 2174 opt: 2176 Z-score: 1448.0 bits: 277.8 E(85289): 6.5e-74 Smith-Waterman score: 3236; 94.2% identity (94.2% similar) in 517 aa overlap (134-620:2-518) 110 120 130 140 150 160 pF1KA1 YFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTF :::::::::::::::::::::::::::::: XP_005 MGWDKHSYGYHGDDGHSFCSSGTGQPYGPTF 10 20 30 170 180 190 200 210 220 pF1KA1 TTGDVIGCCVNLINGTCFYTKNGHSLGIAFTDLPANLYPTVGLQTPGEIVDANFGQQPFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TTGDVIGCCVNLINGTCFYTKNGHSLGIAFTDLPANLYPTVGLQTPGEIVDANFGQQPFL 40 50 60 70 80 90 230 240 250 260 270 280 pF1KA1 FDIEDYMREWRAKVQGTVHCFPISARLGEWQAVLQNMVSSYLVHHGYCATATAFARMTET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FDIEDYMREWRAKVQGTVHCFPISARLGEWQAVLQNMVSSYLVHHGYCATATAFARMTET 100 110 120 130 140 150 290 300 310 320 330 340 pF1KA1 PIQEEQASIKNRQKIQKLVLEGRVGEAIETTQRFYPGLLEHNPNLLFMLKCRQFVEMVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PIQEEQASIKNRQKIQKLVLEGRVGEAIETTQRFYPGLLEHNPNLLFMLKCRQFVEMVNG 160 170 180 190 200 210 350 360 370 380 390 400 pF1KA1 TDSEVRSLSSRSPKSQDSYPGSPSLSPRHGPSSSHMHNTGADSPSCSNGVASTKSKQNHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TDSEVRSLSSRSPKSQDSYPGSPSLSPRHGPSSSHMHNTGADSPSCSNGVASTKSKQNHS 220 230 240 250 260 270 410 420 430 440 450 pF1KA1 KYPAPSSSSSSSSSSSSSSPSSVNYSESNSTDSTKSQHHSSTSNQETS------------ :::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KYPAPSSSSSSSSSSSSSSPSSVNYSESNSTDSTKSQHHSSTSNQETSNPWLQLERRPNQ 280 290 300 310 320 330 460 470 480 490 pF1KA1 ------------------DSEMEMEAEHYPNGVLGSMSTRIVNGAYKHEDLQTDESSMDD :::::::::::::::::::::::::::::::::::::::::: XP_005 AAPTTPPGPTPTSTPPHSDSEMEMEAEHYPNGVLGSMSTRIVNGAYKHEDLQTDESSMDD 340 350 360 370 380 390 500 510 520 530 540 550 pF1KA1 RHPRRQLCGGNQAATERIILFGRELQALSEQLGREYGKNLAHTEMLQDAFSLLAYSDPWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RHPRRQLCGGNQAATERIILFGRELQALSEQLGREYGKNLAHTEMLQDAFSLLAYSDPWS 400 410 420 430 440 450 560 570 580 590 600 610 pF1KA1 CPVGQQLDPIQREPVCAALNSAILESQNLPKQPPLMLALGQASECLRLMARAGLGSCSFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CPVGQQLDPIQREPVCAALNSAILESQNLPKQPPLMLALGQASECLRLMARAGLGSCSFA 460 470 480 490 500 510 620 pF1KA1 RVDDYLH ::::::: XP_005 RVDDYLH 620 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 21:13:15 2016 done: Wed Nov 2 21:13:16 2016 Total Scan time: 13.030 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]