FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1503, 790 aa 1>>>pF1KA1503 790 - 790 aa - 790 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4503+/-0.000413; mu= 14.7107+/- 0.026 mean_var=90.3361+/-18.173, 0's: 0 Z-trim(112.3): 102 B-trim: 18 in 1/52 Lambda= 0.134941 statistics sampled from 21090 (21192) to 21090 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.61), E-opt: 0.2 (0.248), width: 16 Scan time: 9.800 The best scores are: opt bits E(85289) XP_011521969 (OMIM: 603333) PREDICTED: dynein heav (4427) 4244 837.4 0 NP_065928 (OMIM: 603333) dynein heavy chain 2, axo (4427) 4244 837.4 0 NP_001290199 (OMIM: 603333) dynein heavy chain 2, ( 872) 2757 547.6 8.4e-155 XP_011521972 (OMIM: 603333) PREDICTED: dynein heav (3551) 2569 511.3 3e-143 XP_016879708 (OMIM: 603333) PREDICTED: dynein heav (3799) 2569 511.3 3.2e-143 XP_011521968 (OMIM: 603333) PREDICTED: dynein heav (4446) 2569 511.3 3.6e-143 XP_011521965 (OMIM: 603333) PREDICTED: dynein heav (4509) 2569 511.3 3.7e-143 XP_011521966 (OMIM: 603333) PREDICTED: dynein heav (4509) 2569 511.3 3.7e-143 XP_011521970 (OMIM: 603333) PREDICTED: dynein heav (3973) 1169 238.7 3.6e-61 XP_011521971 (OMIM: 603333) PREDICTED: dynein heav (3841) 322 73.8 1.5e-11 XP_011536322 (OMIM: 605884) PREDICTED: dynein heav (2591) 306 70.6 9.5e-11 NP_997320 (OMIM: 605884) dynein heavy chain 10, ax (4471) 306 70.7 1.5e-10 XP_011536319 (OMIM: 605884) PREDICTED: dynein heav (4477) 306 70.7 1.5e-10 XP_016874450 (OMIM: 605884) PREDICTED: dynein heav (4486) 306 70.7 1.5e-10 XP_016874449 (OMIM: 605884) PREDICTED: dynein heav (4494) 306 70.7 1.5e-10 XP_011536317 (OMIM: 605884) PREDICTED: dynein heav (4526) 306 70.7 1.5e-10 XP_011536318 (OMIM: 605884) PREDICTED: dynein heav (4526) 306 70.7 1.5e-10 XP_011536316 (OMIM: 605884) PREDICTED: dynein heav (4536) 306 70.7 1.5e-10 XP_005253612 (OMIM: 605884) PREDICTED: dynein heav (4589) 306 70.8 1.6e-10 XP_016865816 (OMIM: 603337) PREDICTED: dynein heav (2857) 291 67.7 7.8e-10 XP_016865815 (OMIM: 603337) PREDICTED: dynein heav (4081) 291 67.8 1.1e-09 XP_016865814 (OMIM: 603337) PREDICTED: dynein heav (4459) 291 67.8 1.1e-09 XP_011512623 (OMIM: 603337) PREDICTED: dynein heav (4490) 291 67.8 1.2e-09 XP_011512622 (OMIM: 603337) PREDICTED: dynein heav (4628) 291 67.8 1.2e-09 XP_011512621 (OMIM: 603337) PREDICTED: dynein heav (4671) 291 67.8 1.2e-09 XP_011512620 (OMIM: 603337) PREDICTED: dynein heav (4686) 291 67.8 1.2e-09 NP_001193856 (OMIM: 603337) dynein heavy chain 8, (4707) 291 67.8 1.2e-09 XP_016864676 (OMIM: 603335,608644) PREDICTED: dyne (2679) 279 65.4 3.7e-09 XP_016864673 (OMIM: 603335,608644) PREDICTED: dyne (3071) 279 65.4 4.2e-09 XP_016864672 (OMIM: 603335,608644) PREDICTED: dyne (3238) 279 65.4 4.4e-09 XP_016864671 (OMIM: 603335,608644) PREDICTED: dyne (3809) 279 65.5 5.1e-09 XP_016864670 (OMIM: 603335,608644) PREDICTED: dyne (3960) 279 65.5 5.2e-09 XP_016864669 (OMIM: 603335,608644) PREDICTED: dyne (4272) 279 65.5 5.6e-09 XP_016864666 (OMIM: 603335,608644) PREDICTED: dyne (4520) 279 65.5 5.9e-09 NP_001360 (OMIM: 603335,608644) dynein heavy chain (4624) 279 65.5 6e-09 XP_005248319 (OMIM: 603335,608644) PREDICTED: dyne (4660) 279 65.5 6e-09 NP_775899 (OMIM: 610063) dynein heavy chain 17, ax (4462) 255 60.8 1.5e-07 XP_011523718 (OMIM: 610063) PREDICTED: dynein heav (4466) 255 60.8 1.5e-07 XP_016884720 (OMIM: 300927) PREDICTED: peroxiredox ( 336) 235 56.4 2.3e-07 XP_016884719 (OMIM: 300927) PREDICTED: peroxiredox ( 350) 235 56.4 2.4e-07 XP_016879784 (OMIM: 603330) PREDICTED: dynein heav (2548) 244 58.6 4e-07 XP_016879783 (OMIM: 603330) PREDICTED: dynein heav (3362) 244 58.6 5.1e-07 XP_016879781 (OMIM: 603330) PREDICTED: dynein heav (4462) 244 58.7 6.5e-07 NP_001363 (OMIM: 603330) dynein heavy chain 9, axo (4486) 244 58.7 6.6e-07 XP_011522005 (OMIM: 603330) PREDICTED: dynein heav (4501) 244 58.7 6.6e-07 XP_016862087 (OMIM: 606671) PREDICTED: NCK-interac ( 677) 200 49.8 4.8e-05 XP_016862085 (OMIM: 606671) PREDICTED: NCK-interac ( 684) 200 49.8 4.8e-05 XP_016862086 (OMIM: 606671) PREDICTED: NCK-interac ( 684) 200 49.8 4.8e-05 XP_016862084 (OMIM: 606671) PREDICTED: NCK-interac ( 755) 200 49.8 5.3e-05 XP_016862083 (OMIM: 606671) PREDICTED: NCK-interac ( 762) 200 49.8 5.3e-05 >>XP_011521969 (OMIM: 603333) PREDICTED: dynein heavy ch (4427 aa) initn: 4244 init1: 4244 opt: 4244 Z-score: 4453.6 bits: 837.4 E(85289): 0 Smith-Waterman score: 4244; 100.0% identity (100.0% similar) in 635 aa overlap (1-635:1-635) 10 20 30 40 50 60 pF1KA1 MSSKAEKKQRLSGRGSSQASWSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSSKAEKKQRLSGRGSSQASWSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GPQAQSEESVEPEADVKPLFLSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPQAQSEESVEPEADVKPLFLSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 CFGLKLELGMPVQTQNQLVYFIRQAPVPITWENFEATVQFGTVRGPYIPALLRLLGGVFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CFGLKLELGMPVQTQNQLVYFIRQAPVPITWENFEATVQFGTVRGPYIPALLRLLGGVFA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 PQIFANTGWPESIRNHFASHLHKFLACLTDTRYKLEGHTVLYIPAEAMNMKPEMVIKDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQIFANTGWPESIRNHFASHLHKFLACLTDTRYKLEGHTVLYIPAEAMNMKPEMVIKDKE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 LVQRLETSMIHWTRQIKEMLSAQETVETGENLGPLEEIEFWRNRCMDLSGISKQLVKKGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVQRLETSMIHWTRQIKEMLSAQETVETGENLGPLEEIEFWRNRCMDLSGISKQLVKKGV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 KHVESILHLAKSSYLAPFMKLAQQIQDGSRQAQSNLTFLSILKEPYQELAFMKPKDISSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KHVESILHLAKSSYLAPFMKLAQQIQDGSRQAQSNLTFLSILKEPYQELAFMKPKDISSK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 LPKLISLIRIIWVNSPHYNTRERLTSLFRKVCDCQYHFARWEDGKQGPLPCFFGAQGPQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPKLISLIRIIWVNSPHYNTRERLTSLFRKVCDCQYHFARWEDGKQGPLPCFFGAQGPQI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 TRNLLEIEDIFHKNLHTLRAVRGGILDVKNTCWHEDYNKFRAGIKDLEVMTQNLITSAFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRNLLEIEDIFHKNLHTLRAVRGGILDVKNTCWHEDYNKFRAGIKDLEVMTQNLITSAFE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 LVRDVPHGVLLLDTFHRLASREAIKRTYDKKAVDLYMLFNSELALVNRERNKKWPDLEPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVRDVPHGVLLLDTFHRLASREAIKRTYDKKAVDLYMLFNSELALVNRERNKKWPDLEPY 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 VAQYSGKARWVHILRRRIDRVMTCLAGAHFLPRIGTGKESVHTYQQMVQAIDELVRKTFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAQYSGKARWVHILRRRIDRVMTCLAGAHFLPRIGTGKESVHTYQQMVQAIDELVRKTFQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 EWTSSLDKDCIRRLDTPLLRISQEKAGMLDVNFDKYRSHLAPFPYTPLLQLSQEFHSHLL ::::::::::::::::::::::::::::::::::: XP_011 EWTSSLDKDCIRRLDTPLLRISQEKAGMLDVNFDKSLLILFAEIDYWERLLFETPHYVVN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 TPLFIILSLSHTICLLSSFYFFFSSFIFVSPHLPPCYQHFNFTTYLKTQQNKTMIGQARW XP_011 VAERAEDLRILRENLLLVARDYNRIIAMLSPDEQALFKERIRLLDKKIHPGLKKLHWALK 670 680 690 700 710 720 >>NP_065928 (OMIM: 603333) dynein heavy chain 2, axonema (4427 aa) initn: 4244 init1: 4244 opt: 4244 Z-score: 4453.6 bits: 837.4 E(85289): 0 Smith-Waterman score: 4244; 100.0% identity (100.0% similar) in 635 aa overlap (1-635:1-635) 10 20 30 40 50 60 pF1KA1 MSSKAEKKQRLSGRGSSQASWSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MSSKAEKKQRLSGRGSSQASWSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GPQAQSEESVEPEADVKPLFLSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GPQAQSEESVEPEADVKPLFLSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 CFGLKLELGMPVQTQNQLVYFIRQAPVPITWENFEATVQFGTVRGPYIPALLRLLGGVFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 CFGLKLELGMPVQTQNQLVYFIRQAPVPITWENFEATVQFGTVRGPYIPALLRLLGGVFA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 PQIFANTGWPESIRNHFASHLHKFLACLTDTRYKLEGHTVLYIPAEAMNMKPEMVIKDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 PQIFANTGWPESIRNHFASHLHKFLACLTDTRYKLEGHTVLYIPAEAMNMKPEMVIKDKE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 LVQRLETSMIHWTRQIKEMLSAQETVETGENLGPLEEIEFWRNRCMDLSGISKQLVKKGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LVQRLETSMIHWTRQIKEMLSAQETVETGENLGPLEEIEFWRNRCMDLSGISKQLVKKGV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 KHVESILHLAKSSYLAPFMKLAQQIQDGSRQAQSNLTFLSILKEPYQELAFMKPKDISSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 KHVESILHLAKSSYLAPFMKLAQQIQDGSRQAQSNLTFLSILKEPYQELAFMKPKDISSK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 LPKLISLIRIIWVNSPHYNTRERLTSLFRKVCDCQYHFARWEDGKQGPLPCFFGAQGPQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LPKLISLIRIIWVNSPHYNTRERLTSLFRKVCDCQYHFARWEDGKQGPLPCFFGAQGPQI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 TRNLLEIEDIFHKNLHTLRAVRGGILDVKNTCWHEDYNKFRAGIKDLEVMTQNLITSAFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 TRNLLEIEDIFHKNLHTLRAVRGGILDVKNTCWHEDYNKFRAGIKDLEVMTQNLITSAFE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 LVRDVPHGVLLLDTFHRLASREAIKRTYDKKAVDLYMLFNSELALVNRERNKKWPDLEPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LVRDVPHGVLLLDTFHRLASREAIKRTYDKKAVDLYMLFNSELALVNRERNKKWPDLEPY 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 VAQYSGKARWVHILRRRIDRVMTCLAGAHFLPRIGTGKESVHTYQQMVQAIDELVRKTFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 VAQYSGKARWVHILRRRIDRVMTCLAGAHFLPRIGTGKESVHTYQQMVQAIDELVRKTFQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 EWTSSLDKDCIRRLDTPLLRISQEKAGMLDVNFDKYRSHLAPFPYTPLLQLSQEFHSHLL ::::::::::::::::::::::::::::::::::: NP_065 EWTSSLDKDCIRRLDTPLLRISQEKAGMLDVNFDKSLLILFAEIDYWERLLFETPHYVVN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 TPLFIILSLSHTICLLSSFYFFFSSFIFVSPHLPPCYQHFNFTTYLKTQQNKTMIGQARW NP_065 VAERAEDLRILRENLLLVARDYNRIIAMLSPDEQALFKERIRLLDKKIHPGLKKLHWALK 670 680 690 700 710 720 >>NP_001290199 (OMIM: 603333) dynein heavy chain 2, axon (872 aa) initn: 2757 init1: 2757 opt: 2757 Z-score: 2900.2 bits: 547.6 E(85289): 8.4e-155 Smith-Waterman score: 4837; 89.8% identity (89.9% similar) in 822 aa overlap (51-790:51-872) 30 40 50 60 70 80 pF1KA1 WSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLEGPQAQSEESVEPEADVKPLF :::::::::::::::::::::::::::::: NP_001 WSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLEGPQAQSEESVEPEADVKPLF 30 40 50 60 70 80 90 100 110 120 130 140 pF1KA1 LSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDPCFGLKLELGMPVQTQNQLVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDPCFGLKLELGMPVQTQNQLVY 90 100 110 120 130 140 150 160 170 180 190 200 pF1KA1 FIRQAPVPITWENFEATVQFGTVRGPYIPALLRLLGGVFAPQIFANTGWPESIRNHFASH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FIRQAPVPITWENFEATVQFGTVRGPYIPALLRLLGGVFAPQIFANTGWPESIRNHFASH 150 160 170 180 190 200 210 220 230 240 250 260 pF1KA1 LHKFLACLTDTRYKLEGHTVLYIPAEAMNMKPEMVIKDKELVQRLETSMIHWTRQIKEML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHKFLACLTDTRYKLEGHTVLYIPAEAMNMKPEMVIKDKELVQRLETSMIHWTRQIKEML 210 220 230 240 250 260 270 280 290 300 310 320 pF1KA1 SAQETVETGENLGPLEEIEFWRNRCMDLSGISKQLVKKGVKHVESILHLAKSSYLAPFMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAQETVETGENLGPLEEIEFWRNRCMDLSGISKQLVKKGVKHVESILHLAKSSYLAPFMK 270 280 290 300 310 320 330 340 350 360 370 380 pF1KA1 LAQQIQDGSRQAQSNLTFLSILKEPYQELAFMKPKDISSKLPKLISLIRIIWVNSPHYNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAQQIQDGSRQAQSNLTFLSILKEPYQELAFMKPKDISSKLPKLISLIRIIWVNSPHYNT 330 340 350 360 370 380 390 pF1KA1 RERLTSLFRK-------------------------------------------------- :::::::::: NP_001 RERLTSLFRKMSNEIIRLCCHAISLDRIFEGYVSSSKEDLQGCILCCHAWKDHYVQAVQM 390 400 410 420 430 440 400 410 pF1KA1 --------------------------------VCDCQYHFARWEDGKQGPLPCFFGAQGP :::::::::::::::::::::::::::: NP_001 HIQFSSRGWVLDQTSIFAQVDAFVQRCKDLIEVCDCQYHFARWEDGKQGPLPCFFGAQGP 450 460 470 480 490 500 420 430 440 450 460 470 pF1KA1 QITRNLLEIEDIFHKNLHTLRAVRGGILDVKNTCWHEDYNKFRAGIKDLEVMTQNLITSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QITRNLLEIEDIFHKNLHTLRAVRGGILDVKNTCWHEDYNKFRAGIKDLEVMTQNLITSA 510 520 530 540 550 560 480 490 500 510 520 530 pF1KA1 FELVRDVPHGVLLLDTFHRLASREAIKRTYDKKAVDLYMLFNSELALVNRERNKKWPDLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FELVRDVPHGVLLLDTFHRLASREAIKRTYDKKAVDLYMLFNSELALVNRERNKKWPDLE 570 580 590 600 610 620 540 550 560 570 580 590 pF1KA1 PYVAQYSGKARWVHILRRRIDRVMTCLAGAHFLPRIGTGKESVHTYQQMVQAIDELVRKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PYVAQYSGKARWVHILRRRIDRVMTCLAGAHFLPRIGTGKESVHTYQQMVQAIDELVRKT 630 640 650 660 670 680 600 610 620 630 640 650 pF1KA1 FQEWTSSLDKDCIRRLDTPLLRISQEKAGMLDVNFDKYRSHLAPFPYTPLLQLSQEFHSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FQEWTSSLDKDCIRRLDTPLLRISQEKAGMLDVNFDKYRSHLAPFPYTPLLQLSQEFHSH 690 700 710 720 730 740 660 670 680 690 700 710 pF1KA1 LLTPLFIILSLSHTICLLSSFYFFFSSFIFVSPHLPPCYQHFNFTTYLKTQQNKTMIGQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLTPLFIILSLSHTICLLSSFYFFFSSFIFVSPHLPPCYQHFNFTTYLKTQQNKTMIGQA 750 760 770 780 790 800 720 730 740 750 760 770 pF1KA1 RWLTPVIPALWEAGVGASLEPRSLRTAWATWQNPVSAKNTKISWAWWHKPVVSATWEGEV ::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::: NP_001 RWLTPVIPALWEAEVGASLEPRSLRTAWATWQNPVSAKNTKISWAWWHKPVVSATWEGEV 810 820 830 840 850 860 780 790 pF1KA1 GGSPEPGRRRLQ ::::::::.::: NP_001 GGSPEPGRQRLQ 870 >-- initn: 312 init1: 312 opt: 312 Z-score: 327.7 bits: 71.6 E(85289): 1.6e-11 Smith-Waterman score: 312; 100.0% identity (100.0% similar) in 50 aa overlap (1-50:1-50) 10 20 30 40 50 60 pF1KA1 MSSKAEKKQRLSGRGSSQASWSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLE :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSKAEKKQRLSGRGSSQASWSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GPQAQSEESVEPEADVKPLFLSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDP NP_001 GPQAQSEESVEPEADVKPLFLSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDP 70 80 90 100 110 120 >>XP_011521972 (OMIM: 603333) PREDICTED: dynein heavy ch (3551 aa) initn: 2569 init1: 2569 opt: 2569 Z-score: 2692.8 bits: 511.3 E(85289): 3e-143 Smith-Waterman score: 4070; 88.6% identity (88.6% similar) in 717 aa overlap (1-635:1-717) 10 20 30 40 50 60 pF1KA1 MSSKAEKKQRLSGRGSSQASWSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSSKAEKKQRLSGRGSSQASWSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GPQAQSEESVEPEADVKPLFLSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPQAQSEESVEPEADVKPLFLSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 CFGLKLELGMPVQTQNQLVYFIRQAPVPITWENFEATVQFGTVRGPYIPALLRLLGGVFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CFGLKLELGMPVQTQNQLVYFIRQAPVPITWENFEATVQFGTVRGPYIPALLRLLGGVFA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 PQIFANTGWPESIRNHFASHLHKFLACLTDTRYKLEGHTVLYIPAEAMNMKPEMVIKDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQIFANTGWPESIRNHFASHLHKFLACLTDTRYKLEGHTVLYIPAEAMNMKPEMVIKDKE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 LVQRLETSMIHWTRQIKEMLSAQETVETGENLGPLEEIEFWRNRCMDLSGISKQLVKKGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVQRLETSMIHWTRQIKEMLSAQETVETGENLGPLEEIEFWRNRCMDLSGISKQLVKKGV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 KHVESILHLAKSSYLAPFMKLAQQIQDGSRQAQSNLTFLSILKEPYQELAFMKPKDISSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KHVESILHLAKSSYLAPFMKLAQQIQDGSRQAQSNLTFLSILKEPYQELAFMKPKDISSK 310 320 330 340 350 360 370 380 390 pF1KA1 LPKLISLIRIIWVNSPHYNTRERLTSLFRK------------------------------ :::::::::::::::::::::::::::::: XP_011 LPKLISLIRIIWVNSPHYNTRERLTSLFRKMSNEIIRLCCHAISLDRIFEGYVSSSKEDL 370 380 390 400 410 420 pF1KA1 ----------------------------------------------------VCDCQYHF :::::::: XP_011 QGCILCCHAWKDHYVQAVQMHIQFSSRGWVLDQTSIFAQVDAFVQRCKDLIEVCDCQYHF 430 440 450 460 470 480 400 410 420 430 440 450 pF1KA1 ARWEDGKQGPLPCFFGAQGPQITRNLLEIEDIFHKNLHTLRAVRGGILDVKNTCWHEDYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARWEDGKQGPLPCFFGAQGPQITRNLLEIEDIFHKNLHTLRAVRGGILDVKNTCWHEDYN 490 500 510 520 530 540 460 470 480 490 500 510 pF1KA1 KFRAGIKDLEVMTQNLITSAFELVRDVPHGVLLLDTFHRLASREAIKRTYDKKAVDLYML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KFRAGIKDLEVMTQNLITSAFELVRDVPHGVLLLDTFHRLASREAIKRTYDKKAVDLYML 550 560 570 580 590 600 520 530 540 550 560 570 pF1KA1 FNSELALVNRERNKKWPDLEPYVAQYSGKARWVHILRRRIDRVMTCLAGAHFLPRIGTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FNSELALVNRERNKKWPDLEPYVAQYSGKARWVHILRRRIDRVMTCLAGAHFLPRIGTGK 610 620 630 640 650 660 580 590 600 610 620 630 pF1KA1 ESVHTYQQMVQAIDELVRKTFQEWTSSLDKDCIRRLDTPLLRISQEKAGMLDVNFDKYRS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESVHTYQQMVQAIDELVRKTFQEWTSSLDKDCIRRLDTPLLRISQEKAGMLDVNFDKSLL 670 680 690 700 710 720 640 650 660 670 680 690 pF1KA1 HLAPFPYTPLLQLSQEFHSHLLTPLFIILSLSHTICLLSSFYFFFSSFIFVSPHLPPCYQ XP_011 ILFAEIDYWERLLFETPHYVVNVAERAEDLRILRENLLLVARDYNRIIAMLSPDEQALFK 730 740 750 760 770 780 >>XP_016879708 (OMIM: 603333) PREDICTED: dynein heavy ch (3799 aa) initn: 2569 init1: 2569 opt: 2569 Z-score: 2692.4 bits: 511.3 E(85289): 3.2e-143 Smith-Waterman score: 4070; 88.6% identity (88.6% similar) in 717 aa overlap (1-635:1-717) 10 20 30 40 50 60 pF1KA1 MSSKAEKKQRLSGRGSSQASWSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSSKAEKKQRLSGRGSSQASWSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GPQAQSEESVEPEADVKPLFLSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPQAQSEESVEPEADVKPLFLSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 CFGLKLELGMPVQTQNQLVYFIRQAPVPITWENFEATVQFGTVRGPYIPALLRLLGGVFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CFGLKLELGMPVQTQNQLVYFIRQAPVPITWENFEATVQFGTVRGPYIPALLRLLGGVFA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 PQIFANTGWPESIRNHFASHLHKFLACLTDTRYKLEGHTVLYIPAEAMNMKPEMVIKDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQIFANTGWPESIRNHFASHLHKFLACLTDTRYKLEGHTVLYIPAEAMNMKPEMVIKDKE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 LVQRLETSMIHWTRQIKEMLSAQETVETGENLGPLEEIEFWRNRCMDLSGISKQLVKKGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVQRLETSMIHWTRQIKEMLSAQETVETGENLGPLEEIEFWRNRCMDLSGISKQLVKKGV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 KHVESILHLAKSSYLAPFMKLAQQIQDGSRQAQSNLTFLSILKEPYQELAFMKPKDISSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KHVESILHLAKSSYLAPFMKLAQQIQDGSRQAQSNLTFLSILKEPYQELAFMKPKDISSK 310 320 330 340 350 360 370 380 390 pF1KA1 LPKLISLIRIIWVNSPHYNTRERLTSLFRK------------------------------ :::::::::::::::::::::::::::::: XP_016 LPKLISLIRIIWVNSPHYNTRERLTSLFRKMSNEIIRLCCHAISLDRIFEGYVSSSKEDL 370 380 390 400 410 420 pF1KA1 ----------------------------------------------------VCDCQYHF :::::::: XP_016 QGCILCCHAWKDHYVQAVQMHIQFSSRGWVLDQTSIFAQVDAFVQRCKDLIEVCDCQYHF 430 440 450 460 470 480 400 410 420 430 440 450 pF1KA1 ARWEDGKQGPLPCFFGAQGPQITRNLLEIEDIFHKNLHTLRAVRGGILDVKNTCWHEDYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARWEDGKQGPLPCFFGAQGPQITRNLLEIEDIFHKNLHTLRAVRGGILDVKNTCWHEDYN 490 500 510 520 530 540 460 470 480 490 500 510 pF1KA1 KFRAGIKDLEVMTQNLITSAFELVRDVPHGVLLLDTFHRLASREAIKRTYDKKAVDLYML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KFRAGIKDLEVMTQNLITSAFELVRDVPHGVLLLDTFHRLASREAIKRTYDKKAVDLYML 550 560 570 580 590 600 520 530 540 550 560 570 pF1KA1 FNSELALVNRERNKKWPDLEPYVAQYSGKARWVHILRRRIDRVMTCLAGAHFLPRIGTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FNSELALVNRERNKKWPDLEPYVAQYSGKARWVHILRRRIDRVMTCLAGAHFLPRIGTGK 610 620 630 640 650 660 580 590 600 610 620 630 pF1KA1 ESVHTYQQMVQAIDELVRKTFQEWTSSLDKDCIRRLDTPLLRISQEKAGMLDVNFDKYRS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESVHTYQQMVQAIDELVRKTFQEWTSSLDKDCIRRLDTPLLRISQEKAGMLDVNFDKSLL 670 680 690 700 710 720 640 650 660 670 680 690 pF1KA1 HLAPFPYTPLLQLSQEFHSHLLTPLFIILSLSHTICLLSSFYFFFSSFIFVSPHLPPCYQ XP_016 ILFAEIDYWERLLFETPHYVVNVAERAEDLRILRENLLLVARDYNRIIAMLSPDEQALFK 730 740 750 760 770 780 >>XP_011521968 (OMIM: 603333) PREDICTED: dynein heavy ch (4446 aa) initn: 2569 init1: 2569 opt: 2569 Z-score: 2691.3 bits: 511.3 E(85289): 3.6e-143 Smith-Waterman score: 4070; 88.6% identity (88.6% similar) in 717 aa overlap (1-635:1-717) 10 20 30 40 50 60 pF1KA1 MSSKAEKKQRLSGRGSSQASWSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSSKAEKKQRLSGRGSSQASWSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GPQAQSEESVEPEADVKPLFLSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPQAQSEESVEPEADVKPLFLSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 CFGLKLELGMPVQTQNQLVYFIRQAPVPITWENFEATVQFGTVRGPYIPALLRLLGGVFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CFGLKLELGMPVQTQNQLVYFIRQAPVPITWENFEATVQFGTVRGPYIPALLRLLGGVFA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 PQIFANTGWPESIRNHFASHLHKFLACLTDTRYKLEGHTVLYIPAEAMNMKPEMVIKDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQIFANTGWPESIRNHFASHLHKFLACLTDTRYKLEGHTVLYIPAEAMNMKPEMVIKDKE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 LVQRLETSMIHWTRQIKEMLSAQETVETGENLGPLEEIEFWRNRCMDLSGISKQLVKKGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVQRLETSMIHWTRQIKEMLSAQETVETGENLGPLEEIEFWRNRCMDLSGISKQLVKKGV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 KHVESILHLAKSSYLAPFMKLAQQIQDGSRQAQSNLTFLSILKEPYQELAFMKPKDISSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KHVESILHLAKSSYLAPFMKLAQQIQDGSRQAQSNLTFLSILKEPYQELAFMKPKDISSK 310 320 330 340 350 360 370 380 390 pF1KA1 LPKLISLIRIIWVNSPHYNTRERLTSLFRK------------------------------ :::::::::::::::::::::::::::::: XP_011 LPKLISLIRIIWVNSPHYNTRERLTSLFRKMSNEIIRLCCHAISLDRIFEGYVSSSKEDL 370 380 390 400 410 420 pF1KA1 ----------------------------------------------------VCDCQYHF :::::::: XP_011 QGCILCCHAWKDHYVQAVQMHIQFSSRGWVLDQTSIFAQVDAFVQRCKDLIEVCDCQYHF 430 440 450 460 470 480 400 410 420 430 440 450 pF1KA1 ARWEDGKQGPLPCFFGAQGPQITRNLLEIEDIFHKNLHTLRAVRGGILDVKNTCWHEDYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARWEDGKQGPLPCFFGAQGPQITRNLLEIEDIFHKNLHTLRAVRGGILDVKNTCWHEDYN 490 500 510 520 530 540 460 470 480 490 500 510 pF1KA1 KFRAGIKDLEVMTQNLITSAFELVRDVPHGVLLLDTFHRLASREAIKRTYDKKAVDLYML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KFRAGIKDLEVMTQNLITSAFELVRDVPHGVLLLDTFHRLASREAIKRTYDKKAVDLYML 550 560 570 580 590 600 520 530 540 550 560 570 pF1KA1 FNSELALVNRERNKKWPDLEPYVAQYSGKARWVHILRRRIDRVMTCLAGAHFLPRIGTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FNSELALVNRERNKKWPDLEPYVAQYSGKARWVHILRRRIDRVMTCLAGAHFLPRIGTGK 610 620 630 640 650 660 580 590 600 610 620 630 pF1KA1 ESVHTYQQMVQAIDELVRKTFQEWTSSLDKDCIRRLDTPLLRISQEKAGMLDVNFDKYRS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESVHTYQQMVQAIDELVRKTFQEWTSSLDKDCIRRLDTPLLRISQEKAGMLDVNFDKSLL 670 680 690 700 710 720 640 650 660 670 680 690 pF1KA1 HLAPFPYTPLLQLSQEFHSHLLTPLFIILSLSHTICLLSSFYFFFSSFIFVSPHLPPCYQ XP_011 ILFAEIDYWERLLFETPHYVVNVAERAEDLRILRENLLLVARDYNRIIAMLSPDEQALFK 730 740 750 760 770 780 >>XP_011521965 (OMIM: 603333) PREDICTED: dynein heavy ch (4509 aa) initn: 2569 init1: 2569 opt: 2569 Z-score: 2691.2 bits: 511.3 E(85289): 3.7e-143 Smith-Waterman score: 4070; 88.6% identity (88.6% similar) in 717 aa overlap (1-635:1-717) 10 20 30 40 50 60 pF1KA1 MSSKAEKKQRLSGRGSSQASWSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSSKAEKKQRLSGRGSSQASWSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GPQAQSEESVEPEADVKPLFLSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPQAQSEESVEPEADVKPLFLSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 CFGLKLELGMPVQTQNQLVYFIRQAPVPITWENFEATVQFGTVRGPYIPALLRLLGGVFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CFGLKLELGMPVQTQNQLVYFIRQAPVPITWENFEATVQFGTVRGPYIPALLRLLGGVFA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 PQIFANTGWPESIRNHFASHLHKFLACLTDTRYKLEGHTVLYIPAEAMNMKPEMVIKDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQIFANTGWPESIRNHFASHLHKFLACLTDTRYKLEGHTVLYIPAEAMNMKPEMVIKDKE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 LVQRLETSMIHWTRQIKEMLSAQETVETGENLGPLEEIEFWRNRCMDLSGISKQLVKKGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVQRLETSMIHWTRQIKEMLSAQETVETGENLGPLEEIEFWRNRCMDLSGISKQLVKKGV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 KHVESILHLAKSSYLAPFMKLAQQIQDGSRQAQSNLTFLSILKEPYQELAFMKPKDISSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KHVESILHLAKSSYLAPFMKLAQQIQDGSRQAQSNLTFLSILKEPYQELAFMKPKDISSK 310 320 330 340 350 360 370 380 390 pF1KA1 LPKLISLIRIIWVNSPHYNTRERLTSLFRK------------------------------ :::::::::::::::::::::::::::::: XP_011 LPKLISLIRIIWVNSPHYNTRERLTSLFRKMSNEIIRLCCHAISLDRIFEGYVSSSKEDL 370 380 390 400 410 420 pF1KA1 ----------------------------------------------------VCDCQYHF :::::::: XP_011 QGCILCCHAWKDHYVQAVQMHIQFSSRGWVLDQTSIFAQVDAFVQRCKDLIEVCDCQYHF 430 440 450 460 470 480 400 410 420 430 440 450 pF1KA1 ARWEDGKQGPLPCFFGAQGPQITRNLLEIEDIFHKNLHTLRAVRGGILDVKNTCWHEDYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARWEDGKQGPLPCFFGAQGPQITRNLLEIEDIFHKNLHTLRAVRGGILDVKNTCWHEDYN 490 500 510 520 530 540 460 470 480 490 500 510 pF1KA1 KFRAGIKDLEVMTQNLITSAFELVRDVPHGVLLLDTFHRLASREAIKRTYDKKAVDLYML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KFRAGIKDLEVMTQNLITSAFELVRDVPHGVLLLDTFHRLASREAIKRTYDKKAVDLYML 550 560 570 580 590 600 520 530 540 550 560 570 pF1KA1 FNSELALVNRERNKKWPDLEPYVAQYSGKARWVHILRRRIDRVMTCLAGAHFLPRIGTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FNSELALVNRERNKKWPDLEPYVAQYSGKARWVHILRRRIDRVMTCLAGAHFLPRIGTGK 610 620 630 640 650 660 580 590 600 610 620 630 pF1KA1 ESVHTYQQMVQAIDELVRKTFQEWTSSLDKDCIRRLDTPLLRISQEKAGMLDVNFDKYRS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESVHTYQQMVQAIDELVRKTFQEWTSSLDKDCIRRLDTPLLRISQEKAGMLDVNFDKSLL 670 680 690 700 710 720 640 650 660 670 680 690 pF1KA1 HLAPFPYTPLLQLSQEFHSHLLTPLFIILSLSHTICLLSSFYFFFSSFIFVSPHLPPCYQ XP_011 ILFAEIDYWERLLFETPHYVVNVAERAEDLRILRENLLLVARDYNRIIAMLSPDEQALFK 730 740 750 760 770 780 >>XP_011521966 (OMIM: 603333) PREDICTED: dynein heavy ch (4509 aa) initn: 2569 init1: 2569 opt: 2569 Z-score: 2691.2 bits: 511.3 E(85289): 3.7e-143 Smith-Waterman score: 4070; 88.6% identity (88.6% similar) in 717 aa overlap (1-635:1-717) 10 20 30 40 50 60 pF1KA1 MSSKAEKKQRLSGRGSSQASWSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSSKAEKKQRLSGRGSSQASWSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GPQAQSEESVEPEADVKPLFLSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPQAQSEESVEPEADVKPLFLSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 CFGLKLELGMPVQTQNQLVYFIRQAPVPITWENFEATVQFGTVRGPYIPALLRLLGGVFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CFGLKLELGMPVQTQNQLVYFIRQAPVPITWENFEATVQFGTVRGPYIPALLRLLGGVFA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 PQIFANTGWPESIRNHFASHLHKFLACLTDTRYKLEGHTVLYIPAEAMNMKPEMVIKDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQIFANTGWPESIRNHFASHLHKFLACLTDTRYKLEGHTVLYIPAEAMNMKPEMVIKDKE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 LVQRLETSMIHWTRQIKEMLSAQETVETGENLGPLEEIEFWRNRCMDLSGISKQLVKKGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVQRLETSMIHWTRQIKEMLSAQETVETGENLGPLEEIEFWRNRCMDLSGISKQLVKKGV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 KHVESILHLAKSSYLAPFMKLAQQIQDGSRQAQSNLTFLSILKEPYQELAFMKPKDISSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KHVESILHLAKSSYLAPFMKLAQQIQDGSRQAQSNLTFLSILKEPYQELAFMKPKDISSK 310 320 330 340 350 360 370 380 390 pF1KA1 LPKLISLIRIIWVNSPHYNTRERLTSLFRK------------------------------ :::::::::::::::::::::::::::::: XP_011 LPKLISLIRIIWVNSPHYNTRERLTSLFRKMSNEIIRLCCHAISLDRIFEGYVSSSKEDL 370 380 390 400 410 420 pF1KA1 ----------------------------------------------------VCDCQYHF :::::::: XP_011 QGCILCCHAWKDHYVQAVQMHIQFSSRGWVLDQTSIFAQVDAFVQRCKDLIEVCDCQYHF 430 440 450 460 470 480 400 410 420 430 440 450 pF1KA1 ARWEDGKQGPLPCFFGAQGPQITRNLLEIEDIFHKNLHTLRAVRGGILDVKNTCWHEDYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARWEDGKQGPLPCFFGAQGPQITRNLLEIEDIFHKNLHTLRAVRGGILDVKNTCWHEDYN 490 500 510 520 530 540 460 470 480 490 500 510 pF1KA1 KFRAGIKDLEVMTQNLITSAFELVRDVPHGVLLLDTFHRLASREAIKRTYDKKAVDLYML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KFRAGIKDLEVMTQNLITSAFELVRDVPHGVLLLDTFHRLASREAIKRTYDKKAVDLYML 550 560 570 580 590 600 520 530 540 550 560 570 pF1KA1 FNSELALVNRERNKKWPDLEPYVAQYSGKARWVHILRRRIDRVMTCLAGAHFLPRIGTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FNSELALVNRERNKKWPDLEPYVAQYSGKARWVHILRRRIDRVMTCLAGAHFLPRIGTGK 610 620 630 640 650 660 580 590 600 610 620 630 pF1KA1 ESVHTYQQMVQAIDELVRKTFQEWTSSLDKDCIRRLDTPLLRISQEKAGMLDVNFDKYRS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESVHTYQQMVQAIDELVRKTFQEWTSSLDKDCIRRLDTPLLRISQEKAGMLDVNFDKSLL 670 680 690 700 710 720 640 650 660 670 680 690 pF1KA1 HLAPFPYTPLLQLSQEFHSHLLTPLFIILSLSHTICLLSSFYFFFSSFIFVSPHLPPCYQ XP_011 ILFAEIDYWERLLFETPHYVVNVAERAEDLRILRENLLLVARDYNRIIAMLSPDEQALFK 730 740 750 760 770 780 >>XP_011521970 (OMIM: 603333) PREDICTED: dynein heavy ch (3973 aa) initn: 1169 init1: 1169 opt: 1169 Z-score: 1219.1 bits: 238.7 E(85289): 3.6e-61 Smith-Waterman score: 1169; 98.3% identity (98.9% similar) in 180 aa overlap (456-635:2-181) 430 440 450 460 470 480 pF1KA1 EIEDIFHKNLHTLRAVRGGILDVKNTCWHEDYNKFRAGIKDLEVMTQNLITSAFELVRDV : .:::::::::::::::::::::::::: XP_011 MDSCRFRAGIKDLEVMTQNLITSAFELVRDV 10 20 30 490 500 510 520 530 540 pF1KA1 PHGVLLLDTFHRLASREAIKRTYDKKAVDLYMLFNSELALVNRERNKKWPDLEPYVAQYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PHGVLLLDTFHRLASREAIKRTYDKKAVDLYMLFNSELALVNRERNKKWPDLEPYVAQYS 40 50 60 70 80 90 550 560 570 580 590 600 pF1KA1 GKARWVHILRRRIDRVMTCLAGAHFLPRIGTGKESVHTYQQMVQAIDELVRKTFQEWTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GKARWVHILRRRIDRVMTCLAGAHFLPRIGTGKESVHTYQQMVQAIDELVRKTFQEWTSS 100 110 120 130 140 150 610 620 630 640 650 660 pF1KA1 LDKDCIRRLDTPLLRISQEKAGMLDVNFDKYRSHLAPFPYTPLLQLSQEFHSHLLTPLFI :::::::::::::::::::::::::::::: XP_011 LDKDCIRRLDTPLLRISQEKAGMLDVNFDKSLLILFAEIDYWERLLFETPHYVVNVAERA 160 170 180 190 200 210 >>XP_011521971 (OMIM: 603333) PREDICTED: dynein heavy ch (3841 aa) initn: 322 init1: 322 opt: 322 Z-score: 328.2 bits: 73.8 E(85289): 1.5e-11 Smith-Waterman score: 322; 100.0% identity (100.0% similar) in 49 aa overlap (587-635:1-49) 560 570 580 590 600 610 pF1KA1 RIDRVMTCLAGAHFLPRIGTGKESVHTYQQMVQAIDELVRKTFQEWTSSLDKDCIRRLDT :::::::::::::::::::::::::::::: XP_011 MVQAIDELVRKTFQEWTSSLDKDCIRRLDT 10 20 30 620 630 640 650 660 670 pF1KA1 PLLRISQEKAGMLDVNFDKYRSHLAPFPYTPLLQLSQEFHSHLLTPLFIILSLSHTICLL ::::::::::::::::::: XP_011 PLLRISQEKAGMLDVNFDKSLLILFAEIDYWERLLFETPHYVVNVAERAEDLRILRENLL 40 50 60 70 80 90 790 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 20:06:00 2016 done: Thu Nov 3 20:06:02 2016 Total Scan time: 9.800 Total Display time: 0.170 Function used was FASTA [36.3.4 Apr, 2011]