FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1526, 907 aa 1>>>pF1KA1526 907 - 907 aa - 907 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.1014+/-0.000488; mu= -16.4865+/- 0.030 mean_var=440.9124+/-92.960, 0's: 0 Z-trim(120.9): 55 B-trim: 1423 in 1/54 Lambda= 0.061080 statistics sampled from 36790 (36860) to 36790 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.432), width: 16 Scan time: 16.750 The best scores are: opt bits E(85289) NP_056219 (OMIM: 607084,607928,611383) whirlin iso ( 907) 5935 538.3 6.5e-152 NP_001166896 (OMIM: 607084,607928,611383) whirlin ( 906) 5918 536.8 1.8e-151 XP_011516788 (OMIM: 607084,607928,611383) PREDICTE ( 917) 3550 328.1 1.2e-88 XP_011516786 (OMIM: 607084,607928,611383) PREDICTE ( 918) 3549 328.0 1.3e-88 XP_011516787 (OMIM: 607084,607928,611383) PREDICTE ( 918) 3549 328.0 1.3e-88 XP_011516794 (OMIM: 607084,607928,611383) PREDICTE ( 571) 3521 325.4 4.8e-88 XP_011516793 (OMIM: 607084,607928,611383) PREDICTE ( 571) 3521 325.4 4.8e-88 XP_011516791 (OMIM: 607084,607928,611383) PREDICTE ( 577) 3513 324.7 7.9e-88 XP_011516796 (OMIM: 607084,607928,611383) PREDICTE ( 556) 3509 324.4 9.8e-88 NP_001077354 (OMIM: 607084,607928,611383) whirlin ( 524) 3441 318.3 6e-86 XP_011516790 (OMIM: 607084,607928,611383) PREDICTE ( 837) 3079 286.6 3.5e-76 XP_011516797 (OMIM: 607084,607928,611383) PREDICTE ( 477) 2428 229.1 4.1e-59 XP_011516789 (OMIM: 607084,607928,611383) PREDICTE ( 876) 2428 229.2 6.7e-59 NP_079171 (OMIM: 276901,605472,612971) PDZ domain- ( 517) 304 41.9 0.0097 XP_016872157 (OMIM: 276901,605472,612971) PREDICTE ( 528) 304 41.9 0.0098 XP_011538485 (OMIM: 276901,605472,612971) PREDICTE ( 533) 304 41.9 0.0099 >>NP_056219 (OMIM: 607084,607928,611383) whirlin isoform (907 aa) initn: 5935 init1: 5935 opt: 5935 Z-score: 2848.4 bits: 538.3 E(85289): 6.5e-152 Smith-Waterman score: 5935; 100.0% identity (100.0% similar) in 907 aa overlap (1-907:1-907) 10 20 30 40 50 60 pF1KA1 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 ARNTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 ARNTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 KLGREDLQPPSSMPSCSGTVFSAPQNRSPPAGTAPTPGTSSAQDLPSSPIYASVSPANPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KLGREDLQPPSSMPSCSGTVFSAPQNRSPPAGTAPTPGTSSAQDLPSSPIYASVSPANPS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 SKRPLDAHLALVNQHPIGPFPRVQSPPHLKSPSAEATVAGGCLLPPSPSGHPDQTGTNQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SKRPLDAHLALVNQHPIGPFPRVQSPPHLKSPSAEATVAGGCLLPPSPSGHPDQTGTNQH 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 FVMVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSEDSGVDAGEAEASAPGRGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 FVMVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSEDSGVDAGEAEASAPGRGR 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 QSVSTKSRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 QSVSTKSRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 PRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFKTKDRDYIDFLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 PRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFKTKDRDYIDFLV 850 860 870 880 890 900 pF1KA1 TEFNVML ::::::: NP_056 TEFNVML >>NP_001166896 (OMIM: 607084,607928,611383) whirlin isof (906 aa) initn: 5229 init1: 4916 opt: 5918 Z-score: 2840.3 bits: 536.8 E(85289): 1.8e-151 Smith-Waterman score: 5918; 99.9% identity (99.9% similar) in 907 aa overlap (1-907:1-906) 10 20 30 40 50 60 pF1KA1 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 ARNTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARNTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 KLGREDLQPPSSMPSCSGTVFSAPQNRSPPAGTAPTPGTSSAQDLPSSPIYASVSPANPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLGREDLQPPSSMPSCSGTVFSAPQNRSPPAGTAPTPGTSSAQDLPSSPIYASVSPANPS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 SKRPLDAHLALVNQHPIGPFPRVQSPPHLKSPSAEATVAGGCLLPPSPSGHPDQTGTNQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKRPLDAHLALVNQHPIGPFPRVQSPPHLKSPSAEATVAGGCLLPPSPSGHPDQTGTNQH 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 FVMVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSEDSGVDAGEAEASAPGRGR :::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::: NP_001 FVMVEVHRPDSEPDVNEVRALPQTRT-STLSQLSDSGQTLSEDSGVDAGEAEASAPGRGR 730 740 750 760 770 790 800 810 820 830 840 pF1KA1 QSVSTKSRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSVSTKSRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPL 780 790 800 810 820 830 850 860 870 880 890 900 pF1KA1 PRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFKTKDRDYIDFLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFKTKDRDYIDFLV 840 850 860 870 880 890 pF1KA1 TEFNVML ::::::: NP_001 TEFNVML 900 >>XP_011516788 (OMIM: 607084,607928,611383) PREDICTED: w (917 aa) initn: 4947 init1: 3513 opt: 3550 Z-score: 1712.5 bits: 328.1 E(85289): 1.2e-88 Smith-Waterman score: 5886; 98.7% identity (98.7% similar) in 918 aa overlap (1-907:1-917) 10 20 30 40 50 60 pF1KA1 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS 490 500 510 520 530 540 550 560 570 580 pF1KA1 AR-----------NTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLA :: ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARERLLWLIDLMENTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLA 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA1 QGNDLPLGQPRKLGREDLQPPSSMPSCSGTVFSAPQNRSPPAGTAPTPGTSSAQDLPSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGNDLPLGQPRKLGREDLQPPSSMPSCSGTVFSAPQNRSPPAGTAPTPGTSSAQDLPSSP 610 620 630 640 650 660 650 660 670 680 690 700 pF1KA1 IYASVSPANPSSKRPLDAHLALVNQHPIGPFPRVQSPPHLKSPSAEATVAGGCLLPPSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IYASVSPANPSSKRPLDAHLALVNQHPIGPFPRVQSPPHLKSPSAEATVAGGCLLPPSPS 670 680 690 700 710 720 710 720 730 740 750 760 pF1KA1 GHPDQTGTNQHFVMVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSEDSGVDAG ::::::::::::::::::::::::::::::::::::: :::::::::::::::::::::: XP_011 GHPDQTGTNQHFVMVEVHRPDSEPDVNEVRALPQTRT-STLSQLSDSGQTLSEDSGVDAG 730 740 750 760 770 770 780 790 800 810 820 pF1KA1 EAEASAPGRGRQSVSTKSRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAEASAPGRGRQSVSTKSRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIA 780 790 800 810 820 830 830 840 850 860 870 880 pF1KA1 IEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFK 840 850 860 870 880 890 890 900 pF1KA1 TKDRDYIDFLVTEFNVML :::::::::::::::::: XP_011 TKDRDYIDFLVTEFNVML 900 910 >>XP_011516786 (OMIM: 607084,607928,611383) PREDICTED: w (918 aa) initn: 3554 init1: 3513 opt: 3549 Z-score: 1712.0 bits: 328.0 E(85289): 1.3e-88 Smith-Waterman score: 5903; 98.8% identity (98.8% similar) in 918 aa overlap (1-907:1-918) 10 20 30 40 50 60 pF1KA1 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS 490 500 510 520 530 540 550 560 570 580 pF1KA1 AR-----------NTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLA :: ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARERLLWLIDLMENTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLA 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA1 QGNDLPLGQPRKLGREDLQPPSSMPSCSGTVFSAPQNRSPPAGTAPTPGTSSAQDLPSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGNDLPLGQPRKLGREDLQPPSSMPSCSGTVFSAPQNRSPPAGTAPTPGTSSAQDLPSSP 610 620 630 640 650 660 650 660 670 680 690 700 pF1KA1 IYASVSPANPSSKRPLDAHLALVNQHPIGPFPRVQSPPHLKSPSAEATVAGGCLLPPSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IYASVSPANPSSKRPLDAHLALVNQHPIGPFPRVQSPPHLKSPSAEATVAGGCLLPPSPS 670 680 690 700 710 720 710 720 730 740 750 760 pF1KA1 GHPDQTGTNQHFVMVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSEDSGVDAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GHPDQTGTNQHFVMVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSEDSGVDAG 730 740 750 760 770 780 770 780 790 800 810 820 pF1KA1 EAEASAPGRGRQSVSTKSRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAEASAPGRGRQSVSTKSRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIA 790 800 810 820 830 840 830 840 850 860 870 880 pF1KA1 IEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFK 850 860 870 880 890 900 890 900 pF1KA1 TKDRDYIDFLVTEFNVML :::::::::::::::::: XP_011 TKDRDYIDFLVTEFNVML 910 >>XP_011516787 (OMIM: 607084,607928,611383) PREDICTED: w (918 aa) initn: 3554 init1: 3513 opt: 3549 Z-score: 1712.0 bits: 328.0 E(85289): 1.3e-88 Smith-Waterman score: 5903; 98.8% identity (98.8% similar) in 918 aa overlap (1-907:1-918) 10 20 30 40 50 60 pF1KA1 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS 490 500 510 520 530 540 550 560 570 580 pF1KA1 AR-----------NTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLA :: ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARERLLWLIDLMENTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLA 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA1 QGNDLPLGQPRKLGREDLQPPSSMPSCSGTVFSAPQNRSPPAGTAPTPGTSSAQDLPSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGNDLPLGQPRKLGREDLQPPSSMPSCSGTVFSAPQNRSPPAGTAPTPGTSSAQDLPSSP 610 620 630 640 650 660 650 660 670 680 690 700 pF1KA1 IYASVSPANPSSKRPLDAHLALVNQHPIGPFPRVQSPPHLKSPSAEATVAGGCLLPPSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IYASVSPANPSSKRPLDAHLALVNQHPIGPFPRVQSPPHLKSPSAEATVAGGCLLPPSPS 670 680 690 700 710 720 710 720 730 740 750 760 pF1KA1 GHPDQTGTNQHFVMVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSEDSGVDAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GHPDQTGTNQHFVMVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSEDSGVDAG 730 740 750 760 770 780 770 780 790 800 810 820 pF1KA1 EAEASAPGRGRQSVSTKSRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAEASAPGRGRQSVSTKSRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIA 790 800 810 820 830 840 830 840 850 860 870 880 pF1KA1 IEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFK 850 860 870 880 890 900 890 900 pF1KA1 TKDRDYIDFLVTEFNVML :::::::::::::::::: XP_011 TKDRDYIDFLVTEFNVML 910 >>XP_011516794 (OMIM: 607084,607928,611383) PREDICTED: w (571 aa) initn: 3509 init1: 3509 opt: 3521 Z-score: 1701.6 bits: 325.4 E(85289): 4.8e-88 Smith-Waterman score: 3521; 97.7% identity (98.7% similar) in 559 aa overlap (1-559:1-557) 10 20 30 40 50 60 pF1KA1 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 ARNTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPR :: : . :. .. :..: XP_011 ARR--DSDTTSSSLLGGLNERMPVGPGSGCCGL 550 560 570 >>XP_011516793 (OMIM: 607084,607928,611383) PREDICTED: w (571 aa) initn: 3509 init1: 3509 opt: 3521 Z-score: 1701.6 bits: 325.4 E(85289): 4.8e-88 Smith-Waterman score: 3521; 97.7% identity (98.7% similar) in 559 aa overlap (1-559:1-557) 10 20 30 40 50 60 pF1KA1 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 ARNTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPR :: : . :. .. :..: XP_011 ARR--DSDTTSSSLLGGLNERMPVGPGSGCCGL 550 560 570 >>XP_011516791 (OMIM: 607084,607928,611383) PREDICTED: w (577 aa) initn: 3856 init1: 3513 opt: 3513 Z-score: 1697.7 bits: 324.7 E(85289): 7.9e-88 Smith-Waterman score: 3513; 99.6% identity (99.8% similar) in 545 aa overlap (1-545:1-545) 10 20 30 40 50 60 pF1KA1 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 ARNTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPR ::. : XP_011 ARERLLWLIDLMEVIRFPELCSENPVHSNPSSATFLL 550 560 570 >>XP_011516796 (OMIM: 607084,607928,611383) PREDICTED: w (556 aa) initn: 3509 init1: 3509 opt: 3509 Z-score: 1696.1 bits: 324.4 E(85289): 9.8e-88 Smith-Waterman score: 3509; 100.0% identity (100.0% similar) in 542 aa overlap (1-542:1-542) 10 20 30 40 50 60 pF1KA1 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 ARNTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPR :: XP_011 ARVIHHHSSMERQWGE 550 >>NP_001077354 (OMIM: 607084,607928,611383) whirlin isof (524 aa) initn: 3441 init1: 3441 opt: 3441 Z-score: 1664.1 bits: 318.3 E(85289): 6e-86 Smith-Waterman score: 3441; 100.0% identity (100.0% similar) in 524 aa overlap (384-907:1-524) 360 370 380 390 400 410 pF1KA1 LTVKDVGRLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQV :::::::::::::::::::::::::::::: NP_001 MANSAGFLGDLTTEGINKPGFYKGPAGSQV 10 20 30 420 430 440 450 460 470 pF1KA1 TLSSLGNQTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLSSLGNQTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKF 40 50 60 70 80 90 480 490 500 510 520 530 pF1KA1 SLLSEVRGTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLLSEVRGTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHG 100 110 120 130 140 150 540 550 560 570 580 590 pF1KA1 TSTTVSSARNTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLAQGND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSTTVSSARNTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLAQGND 160 170 180 190 200 210 600 610 620 630 640 650 pF1KA1 LPLGQPRKLGREDLQPPSSMPSCSGTVFSAPQNRSPPAGTAPTPGTSSAQDLPSSPIYAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPLGQPRKLGREDLQPPSSMPSCSGTVFSAPQNRSPPAGTAPTPGTSSAQDLPSSPIYAS 220 230 240 250 260 270 660 670 680 690 700 710 pF1KA1 VSPANPSSKRPLDAHLALVNQHPIGPFPRVQSPPHLKSPSAEATVAGGCLLPPSPSGHPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSPANPSSKRPLDAHLALVNQHPIGPFPRVQSPPHLKSPSAEATVAGGCLLPPSPSGHPD 280 290 300 310 320 330 720 730 740 750 760 770 pF1KA1 QTGTNQHFVMVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSEDSGVDAGEAEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QTGTNQHFVMVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSEDSGVDAGEAEA 340 350 360 370 380 390 780 790 800 810 820 830 pF1KA1 SAPGRGRQSVSTKSRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIAIEGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAPGRGRQSVSTKSRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIAIEGG 400 410 420 430 440 450 840 850 860 870 880 890 pF1KA1 ANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFKTKDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFKTKDR 460 470 480 490 500 510 900 pF1KA1 DYIDFLVTEFNVML :::::::::::::: NP_001 DYIDFLVTEFNVML 520 907 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 06:51:00 2016 done: Sat Nov 5 06:51:03 2016 Total Scan time: 16.750 Total Display time: 0.280 Function used was FASTA [36.3.4 Apr, 2011]