Result of FASTA (omim) for
pF1KA1565
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1565, 1275 aa
1>>>pF1KA1565 1275 - 1275 aa - 1275 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 13.8880+/-0.000812; mu= -16.6484+/- 0.050
mean_var=635.1378+/-131.827, 0's: 0 Z-trim(115.5): 596 B-trim: 854 in 1/54
Lambda= 0.050891
statistics sampled from 25402 (26014) to 25402 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.305), width: 16
Scan time: 15.930
The best scores are: opt bits E(85289)
NP_057434 (OMIM: 608684,614851) ninein isoform 6 [ (1377) 8007 605.0 1.1e-171
XP_011535124 (OMIM: 608684,614851) PREDICTED: nine (1450) 7437 563.2 4.6e-159
NP_891989 (OMIM: 608684,614851) ninein isoform 1 [ (2046) 5290 405.7 1.7e-111
NP_891991 (OMIM: 608684,614851) ninein isoform 5 [ (2090) 5290 405.7 1.7e-111
NP_065972 (OMIM: 608684,614851) ninein isoform 2 [ (2133) 5290 405.7 1.7e-111
XP_011535125 (OMIM: 608684,614851) PREDICTED: nine (2096) 5066 389.3 1.5e-106
XP_011535121 (OMIM: 608684,614851) PREDICTED: nine (2076) 4720 363.9 6.6e-99
XP_011535119 (OMIM: 608684,614851) PREDICTED: nine (2163) 4720 363.9 6.8e-99
NP_001305155 (OMIM: 609580) ninein-like protein is (1033) 1248 108.6 2.2e-22
XP_011527495 (OMIM: 609580) PREDICTED: ninein-like (1038) 1230 107.3 5.5e-22
NP_079452 (OMIM: 609580) ninein-like protein isofo (1382) 1182 103.9 7.8e-21
XP_011527492 (OMIM: 609580) PREDICTED: ninein-like (1387) 1164 102.6 2e-20
XP_011527489 (OMIM: 609580) PREDICTED: ninein-like (1465) 1134 100.4 9.4e-20
XP_011527490 (OMIM: 609580) PREDICTED: ninein-like (1454) 1116 99.1 2.3e-19
XP_011527491 (OMIM: 609580) PREDICTED: ninein-like (1454) 1116 99.1 2.3e-19
XP_011527488 (OMIM: 609580) PREDICTED: ninein-like (1470) 1116 99.1 2.3e-19
XP_016883221 (OMIM: 609580) PREDICTED: ninein-like (1470) 1116 99.1 2.3e-19
XP_016883222 (OMIM: 609580) PREDICTED: ninein-like (1290) 1104 98.2 3.9e-19
XP_011527493 (OMIM: 609580) PREDICTED: ninein-like (1295) 1088 97.0 8.9e-19
XP_011527494 (OMIM: 609580) PREDICTED: ninein-like (1082) 613 62.0 2.5e-08
XP_011527496 (OMIM: 609580) PREDICTED: ninein-like (1020) 456 50.5 7e-05
XP_016883223 (OMIM: 609580) PREDICTED: ninein-like ( 896) 448 49.9 9.6e-05
XP_016880170 (OMIM: 160776) PREDICTED: myosin-10 i (1976) 446 50.0 0.00019
XP_016880171 (OMIM: 160776) PREDICTED: myosin-10 i (1976) 446 50.0 0.00019
NP_005955 (OMIM: 160776) myosin-10 isoform 2 [Homo (1976) 446 50.0 0.00019
XP_016880169 (OMIM: 160776) PREDICTED: myosin-10 i (1985) 446 50.0 0.00019
NP_001243024 (OMIM: 160776) myosin-10 isoform 3 [H (1985) 446 50.0 0.00019
XP_016880166 (OMIM: 160776) PREDICTED: myosin-10 i (1986) 446 50.0 0.00019
XP_016880168 (OMIM: 160776) PREDICTED: myosin-10 i (1986) 446 50.0 0.00019
XP_016880167 (OMIM: 160776) PREDICTED: myosin-10 i (1986) 446 50.0 0.00019
XP_011522182 (OMIM: 160776) PREDICTED: myosin-10 i (2006) 446 50.0 0.00019
NP_001242941 (OMIM: 160776) myosin-10 isoform 1 [H (2007) 446 50.0 0.00019
XP_011522181 (OMIM: 160776) PREDICTED: myosin-10 i (2015) 446 50.0 0.00019
XP_011522180 (OMIM: 160776) PREDICTED: myosin-10 i (2016) 446 50.0 0.00019
XP_011522177 (OMIM: 160776) PREDICTED: myosin-10 i (2037) 446 50.1 0.00019
NP_009044 (OMIM: 190370) trichohyalin [Homo sapien (1943) 441 49.7 0.00024
XP_016884295 (OMIM: 153640,153650,155100,160775,60 (1960) 432 49.0 0.00038
XP_016884294 (OMIM: 153640,153650,155100,160775,60 (1960) 432 49.0 0.00038
XP_016884293 (OMIM: 153640,153650,155100,160775,60 (1960) 432 49.0 0.00038
NP_002464 (OMIM: 153640,153650,155100,160775,60020 (1960) 432 49.0 0.00038
XP_011528499 (OMIM: 153640,153650,155100,160775,60 (1960) 432 49.0 0.00038
XP_016884292 (OMIM: 153640,153650,155100,160775,60 (1960) 432 49.0 0.00038
XP_005265132 (OMIM: 602509) PREDICTED: golgin subf (2214) 433 49.1 0.00039
XP_016861676 (OMIM: 602509) PREDICTED: golgin subf (2236) 433 49.1 0.00039
XP_005265129 (OMIM: 602509) PREDICTED: golgin subf (2269) 433 49.1 0.0004
XP_011529848 (OMIM: 117143,616051) PREDICTED: cent (2633) 423 48.5 0.00073
XP_016861677 (OMIM: 602509) PREDICTED: golgin subf (2195) 419 48.1 0.00079
XP_006713173 (OMIM: 602509) PREDICTED: golgin subf (2250) 419 48.1 0.0008
NP_002069 (OMIM: 602509) golgin subfamily A member (2230) 410 47.4 0.0013
NP_001166184 (OMIM: 602509) golgin subfamily A mem (2243) 410 47.5 0.0013
>>NP_057434 (OMIM: 608684,614851) ninein isoform 6 [Homo (1377 aa)
initn: 5517 init1: 5449 opt: 8007 Z-score: 3203.2 bits: 605.0 E(85289): 1.1e-171
Smith-Waterman score: 8007; 99.9% identity (99.9% similar) in 1246 aa overlap (1-1245:1-1246)
10 20 30 40 50 60
pF1KA1 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KEELRKELLEKHQRELQEGRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 KEELRKELLEKHQRELQEGRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEE
790 800 810 820 830 840
850 860 870 880 890
pF1KA1 M-QKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQR
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQR
850 860 870 880 890 900
900 910 920 930 940 950
pF1KA1 LTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQ
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KA1 QENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 QENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKS
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KA1 SLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQ
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KA1 QEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 QEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLW
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KA1 QENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 QENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECD
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KA1 QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMENSVVGSSREGCSSL
::::::::::::::::::::::::::::::::::::::::::::::
NP_057 QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSP
1210 1220 1230 1240 1250 1260
1260 1270
pF1KA1 PEIVCEDAAPEVHCDA
NP_057 HAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLV
1270 1280 1290 1300 1310 1320
>>XP_011535124 (OMIM: 608684,614851) PREDICTED: ninein i (1450 aa)
initn: 5503 init1: 4879 opt: 7437 Z-score: 2976.7 bits: 563.2 E(85289): 4.6e-159
Smith-Waterman score: 7937; 97.6% identity (97.6% similar) in 1276 aa overlap (1-1245:1-1276)
10 20 30 40 50 60
pF1KA1 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
10 20 30 40 50 60
70 80 90
pF1KA1 RVHFDQFKEALILILSRTLSNEEHFQEP------------------------------DC
:::::::::::::::::::::::::::: ::
XP_011 RVHFDQFKEALILILSRTLSNEEHFQEPASVGVSCQQVARVSGPLLNGHKLTHCLLIKDC
70 80 90 100 110 120
100 110 120 130 140 150
pF1KA1 SLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQ
130 140 150 160 170 180
160 170 180 190 200 210
pF1KA1 RSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSI
190 200 210 220 230 240
220 230 240 250 260 270
pF1KA1 CEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSM
250 260 270 280 290 300
280 290 300 310 320 330
pF1KA1 QSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALD
310 320 330 340 350 360
340 350 360 370 380 390
pF1KA1 FSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDL
370 380 390 400 410 420
400 410 420 430 440 450
pF1KA1 DKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGK
430 440 450 460 470 480
460 470 480 490 500 510
pF1KA1 QRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLEN
490 500 510 520 530 540
520 530 540 550 560 570
pF1KA1 VLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRL
550 560 570 580 590 600
580 590 600 610 620 630
pF1KA1 PLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELE
610 620 630 640 650 660
640 650 660 670 680 690
pF1KA1 DKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAH
670 680 690 700 710 720
700 710 720 730 740 750
pF1KA1 HEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAW
730 740 750 760 770 780
760 770 780 790 800 810
pF1KA1 TEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRYESEKLQQEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRYESEKLQQEN
790 800 810 820 830 840
820 830 840 850 860
pF1KA1 SILRNEITTLNEEDSISNLKLGTLNGSQEEM-QKTETVKQENAAVQKMVENLKKQISELK
::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
XP_011 SILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELK
850 860 870 880 890 900
870 880 890 900 910 920
pF1KA1 IKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE
910 920 930 940 950 960
930 940 950 960 970 980
pF1KA1 LERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKIS
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KA1 SVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVA
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KA1 SQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIA
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KA1 THPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 THPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESN
1150 1160 1170 1180 1190 1200
1170 1180 1190 1200 1210 1220
pF1KA1 LLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLEN
1210 1220 1230 1240 1250 1260
1230 1240 1250 1260 1270
pF1KA1 EGLKKKQVKLDEQLMENSVVGSSREGCSSLPEIVCEDAAPEVHCDA
::::::::::::::::
XP_011 EGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQ
1270 1280 1290 1300 1310 1320
>>NP_891989 (OMIM: 608684,614851) ninein isoform 1 [Homo (2046 aa)
initn: 7766 init1: 5202 opt: 5290 Z-score: 2122.9 bits: 405.7 E(85289): 1.7e-111
Smith-Waterman score: 5345; 70.9% identity (84.1% similar) in 1261 aa overlap (1-1244:1-1208)
10 20 30 40 50 60
pF1KA1 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KEELRKELLEKHQRELQEGRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEE
:::::::::::::::::::: ::.. : . ..: . . : :.
NP_891 KEELRKELLEKHQRELQEGR---EKMETECNRRTSQIEAQFQSDC------------QKV
790 800 810 820
850 860 870 880 890
pF1KA1 MQKTETVKQE-NAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQR
.. :.. : .. .. ...:..: : : .: ..:. ::.:. .. :: :.: .:
NP_891 TERCESALQSLEGRYRQELKDLQEQQREEK---SQWEFEKDELTQECAEAQELLKETLKR
830 840 850 860 870 880
900 910 920 930 940 950
pF1KA1 LTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQ
:: . .:::. . . ::.:. :. . :...:: .: .:. .
NP_891 --------EKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLE-DLRNVS------E
890 900 910 920
960 970 980 990 1000 1010
pF1KA1 QENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEK-EALSEELNSCVDKLAK
.. ::.:.. ..:. :. .: . .... . .:.: ... : : : .. ... .
NP_891 TQQSLLSDQILELKSSHK-RELRE-REEVLCQAGASEQLASQRLERLEMEHDQERQEMMS
930 940 950 960 970 980
1020 1030 1040 1050 1060 1070
pF1KA1 SSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS--------R
. : . : : .. ... : ..... : :......... ... .: .
NP_891 KLLAMENI--HKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEE
990 1000 1010 1020 1030 1040
1080 1090 1100 1110 1120
pF1KA1 MKSD--LRVTQQEKEALKQE---VMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWD
...: : . :: .. :... ..::.. ..: .. ..::. : :... ..:
NP_891 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENV--KMATEISRLQQRLQKLEPG
1050 1060 1070 1080 1090 1100
1130 1140 1150 1160 1170 1180
pF1KA1 K-LDHLMNEEQ-QLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGT
.. ..: ... . :. . ..:..... ... . :.. :.: . . :. .::
NP_891 LVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR-RHVLSDLEDDEVRDLGSTGT
1110 1120 1130 1140 1150 1160
1190 1200 1210 1220 1230 1240
pF1KA1 MNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQL
. .:: . :.: :. : .. ::. :: . :. ::.. .:.:::
NP_891 SSVQRQE----------VKIEESEAS--VEGFSELENSEET-RTESWELKNQISQLQEQL
1170 1180 1190 1200
1250 1260 1270
pF1KA1 MENSVVGSSREGCSSLPEIVCEDAAPEVHCDA
:
NP_891 MMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELR
1210 1220 1230 1240 1250 1260
>--
initn: 2659 init1: 2578 opt: 2945 Z-score: 1192.4 bits: 233.5 E(85289): 1.1e-59
Smith-Waterman score: 2945; 68.8% identity (80.7% similar) in 765 aa overlap (510-1245:1229-1959)
480 490 500 510 520 530
pF1KA1 NSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD--P-SSAEFFLQEERLTQM
.:: .:. :. : .: .. : : ...
NP_891 QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRE
1200 1210 1220 1230 1240 1250
540 550 560 570 580 590
pF1KA1 RNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHG---L
. ... :... . :: . .: :. :.:: . . ::: . ..: . .
NP_891 NDCLQEELRMMETRYDEALENNKELTAE--VFRLQDELKKMEEVTETFLSLEKSYDEVKI
1260 1270 1280 1290 1300 1310
600 610 620 630 640 650
pF1KA1 GSEECNPLNMSIEAELVIEQMKEQH-HRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE
.:: : : . .... ::...:. .: ::: : .... : . : .... ... :
NP_891 ENEELNVLVLRLQGK--IEKLQESVVQRCDCCL---WEASLENLEIEPDGNILQLNQTLE
1320 1330 1340 1350 1360 1370
660 670 680 690 700
pF1KA1 NMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKE--AH-----HEATCRHEEEKK-QL
. : .. :..: . :.: :.:.. .:.. :: : . :.:. . :
NP_891 ECVPRVRSVHHVIE----ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQN
1380 1390 1400 1410 1420
710 720 730 740 750 760
pF1KA1 QVKLEEEKTHL--QEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQEL
:: :::. : : :.: ..::. . : .: :. :: ::..:
NP_891 QVILEENTTLLGFQDK-HFQHQATI--------AELELEKTKLQE----------LTRKL
1430 1440 1450 1460
770 780 790 800 810
pF1KA1 EQFHQEQLTSLVEKHTL----EKEELRKELLEKHQ---RELQEG----RYESEKLQQENS
.:..: ::... . :::: : ... : :.:. ::::::::::::
NP_891 ----KERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENS
1470 1480 1490 1500 1510 1520
820 830 840 850 860 870
pF1KA1 ILRNEITTLNEEDSISNLKLGTLNGSQEEM-QKTETVKQENAAVQKMVENLKKQISELKI
:::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_891 ILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKI
1530 1540 1550 1560 1570 1580
880 890 900 910 920 930
pF1KA1 KNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 KNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEEL
1590 1600 1610 1620 1630 1640
940 950 960 970 980 990
pF1KA1 ERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 ERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISS
1650 1660 1670 1680 1690 1700
1000 1010 1020 1030 1040 1050
pF1KA1 VLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 VLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVAS
1710 1720 1730 1740 1750 1760
1060 1070 1080 1090 1100 1110
pF1KA1 QEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 QEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIAT
1770 1780 1790 1800 1810 1820
1120 1130 1140 1150 1160 1170
pF1KA1 HPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 HPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL
1830 1840 1850 1860 1870 1880
1180 1190 1200 1210 1220 1230
pF1KA1 LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENE
1890 1900 1910 1920 1930 1940
1240 1250 1260 1270
pF1KA1 GLKKKQVKLDEQLMENSVVGSSREGCSSLPEIVCEDAAPEVHCDA
:::::::::::::::
NP_891 GLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQA
1950 1960 1970 1980 1990 2000
>>NP_891991 (OMIM: 608684,614851) ninein isoform 5 [Homo (2090 aa)
initn: 7766 init1: 5202 opt: 5290 Z-score: 2122.8 bits: 405.7 E(85289): 1.7e-111
Smith-Waterman score: 5345; 70.9% identity (84.1% similar) in 1261 aa overlap (1-1244:1-1208)
10 20 30 40 50 60
pF1KA1 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KEELRKELLEKHQRELQEGRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEE
:::::::::::::::::::: ::.. : . ..: . . : :.
NP_891 KEELRKELLEKHQRELQEGR---EKMETECNRRTSQIEAQFQSDC------------QKV
790 800 810 820
850 860 870 880 890
pF1KA1 MQKTETVKQE-NAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQR
.. :.. : .. .. ...:..: : : .: ..:. ::.:. .. :: :.: .:
NP_891 TERCESALQSLEGRYRQELKDLQEQQREEK---SQWEFEKDELTQECAEAQELLKETLKR
830 840 850 860 870 880
900 910 920 930 940 950
pF1KA1 LTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQ
:: . .:::. . . ::.:. :. . :...:: .: .:. .
NP_891 --------EKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLE-DLRNVS------E
890 900 910 920
960 970 980 990 1000 1010
pF1KA1 QENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEK-EALSEELNSCVDKLAK
.. ::.:.. ..:. :. .: . .... . .:.: ... : : : .. ... .
NP_891 TQQSLLSDQILELKSSHK-RELRE-REEVLCQAGASEQLASQRLERLEMEHDQERQEMMS
930 940 950 960 970 980
1020 1030 1040 1050 1060 1070
pF1KA1 SSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS--------R
. : . : : .. ... : ..... : :......... ... .: .
NP_891 KLLAMENI--HKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEE
990 1000 1010 1020 1030 1040
1080 1090 1100 1110 1120
pF1KA1 MKSD--LRVTQQEKEALKQE---VMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWD
...: : . :: .. :... ..::.. ..: .. ..::. : :... ..:
NP_891 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENV--KMATEISRLQQRLQKLEPG
1050 1060 1070 1080 1090 1100
1130 1140 1150 1160 1170 1180
pF1KA1 K-LDHLMNEEQ-QLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGT
.. ..: ... . :. . ..:..... ... . :.. :.: . . :. .::
NP_891 LVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR-RHVLSDLEDDEVRDLGSTGT
1110 1120 1130 1140 1150 1160
1190 1200 1210 1220 1230 1240
pF1KA1 MNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQL
. .:: . :.: :. : .. ::. :: . :. ::.. .:.:::
NP_891 SSVQRQE----------VKIEESEAS--VEGFSELENSEET-RTESWELKNQISQLQEQL
1170 1180 1190 1200
1250 1260 1270
pF1KA1 MENSVVGSSREGCSSLPEIVCEDAAPEVHCDA
:
NP_891 MMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELR
1210 1220 1230 1240 1250 1260
>--
initn: 2659 init1: 2578 opt: 2945 Z-score: 1192.3 bits: 233.5 E(85289): 1.1e-59
Smith-Waterman score: 2945; 68.8% identity (80.7% similar) in 765 aa overlap (510-1245:1229-1959)
480 490 500 510 520 530
pF1KA1 NSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD--P-SSAEFFLQEERLTQM
.:: .:. :. : .: .. : : ...
NP_891 QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRE
1200 1210 1220 1230 1240 1250
540 550 560 570 580 590
pF1KA1 RNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHG---L
. ... :... . :: . .: :. :.:: . . ::: . ..: . .
NP_891 NDCLQEELRMMETRYDEALENNKELTAE--VFRLQDELKKMEEVTETFLSLEKSYDEVKI
1260 1270 1280 1290 1300 1310
600 610 620 630 640 650
pF1KA1 GSEECNPLNMSIEAELVIEQMKEQH-HRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE
.:: : : . .... ::...:. .: ::: : .... : . : .... ... :
NP_891 ENEELNVLVLRLQGK--IEKLQESVVQRCDCCL---WEASLENLEIEPDGNILQLNQTLE
1320 1330 1340 1350 1360 1370
660 670 680 690 700
pF1KA1 NMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKE--AH-----HEATCRHEEEKK-QL
. : .. :..: . :.: :.:.. .:.. :: : . :.:. . :
NP_891 ECVPRVRSVHHVIE----ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQN
1380 1390 1400 1410 1420
710 720 730 740 750 760
pF1KA1 QVKLEEEKTHL--QEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQEL
:: :::. : : :.: ..::. . : .: :. :: ::..:
NP_891 QVILEENTTLLGFQDK-HFQHQATI--------AELELEKTKLQE----------LTRKL
1430 1440 1450 1460
770 780 790 800 810
pF1KA1 EQFHQEQLTSLVEKHTL----EKEELRKELLEKHQ---RELQEG----RYESEKLQQENS
.:..: ::... . :::: : ... : :.:. ::::::::::::
NP_891 ----KERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENS
1470 1480 1490 1500 1510 1520
820 830 840 850 860 870
pF1KA1 ILRNEITTLNEEDSISNLKLGTLNGSQEEM-QKTETVKQENAAVQKMVENLKKQISELKI
:::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_891 ILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKI
1530 1540 1550 1560 1570 1580
880 890 900 910 920 930
pF1KA1 KNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 KNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEEL
1590 1600 1610 1620 1630 1640
940 950 960 970 980 990
pF1KA1 ERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 ERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISS
1650 1660 1670 1680 1690 1700
1000 1010 1020 1030 1040 1050
pF1KA1 VLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 VLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVAS
1710 1720 1730 1740 1750 1760
1060 1070 1080 1090 1100 1110
pF1KA1 QEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 QEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIAT
1770 1780 1790 1800 1810 1820
1120 1130 1140 1150 1160 1170
pF1KA1 HPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 HPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL
1830 1840 1850 1860 1870 1880
1180 1190 1200 1210 1220 1230
pF1KA1 LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_891 LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENE
1890 1900 1910 1920 1930 1940
1240 1250 1260 1270
pF1KA1 GLKKKQVKLDEQLMENSVVGSSREGCSSLPEIVCEDAAPEVHCDA
:::::::::::::::
NP_891 GLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQA
1950 1960 1970 1980 1990 2000
>>NP_065972 (OMIM: 608684,614851) ninein isoform 2 [Homo (2133 aa)
initn: 7766 init1: 5202 opt: 5290 Z-score: 2122.7 bits: 405.7 E(85289): 1.7e-111
Smith-Waterman score: 5345; 70.9% identity (84.1% similar) in 1261 aa overlap (1-1244:1-1208)
10 20 30 40 50 60
pF1KA1 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KEELRKELLEKHQRELQEGRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEE
:::::::::::::::::::: ::.. : . ..: . . : :.
NP_065 KEELRKELLEKHQRELQEGR---EKMETECNRRTSQIEAQFQSDC------------QKV
790 800 810 820
850 860 870 880 890
pF1KA1 MQKTETVKQE-NAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQR
.. :.. : .. .. ...:..: : : .: ..:. ::.:. .. :: :.: .:
NP_065 TERCESALQSLEGRYRQELKDLQEQQREEK---SQWEFEKDELTQECAEAQELLKETLKR
830 840 850 860 870 880
900 910 920 930 940 950
pF1KA1 LTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQ
:: . .:::. . . ::.:. :. . :...:: .: .:. .
NP_065 --------EKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLE-DLRNVS------E
890 900 910 920
960 970 980 990 1000 1010
pF1KA1 QENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEK-EALSEELNSCVDKLAK
.. ::.:.. ..:. :. .: . .... . .:.: ... : : : .. ... .
NP_065 TQQSLLSDQILELKSSHK-RELRE-REEVLCQAGASEQLASQRLERLEMEHDQERQEMMS
930 940 950 960 970 980
1020 1030 1040 1050 1060 1070
pF1KA1 SSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS--------R
. : . : : .. ... : ..... : :......... ... .: .
NP_065 KLLAMENI--HKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEE
990 1000 1010 1020 1030 1040
1080 1090 1100 1110 1120
pF1KA1 MKSD--LRVTQQEKEALKQE---VMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWD
...: : . :: .. :... ..::.. ..: .. ..::. : :... ..:
NP_065 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENV--KMATEISRLQQRLQKLEPG
1050 1060 1070 1080 1090 1100
1130 1140 1150 1160 1170 1180
pF1KA1 K-LDHLMNEEQ-QLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGT
.. ..: ... . :. . ..:..... ... . :.. :.: . . :. .::
NP_065 LVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR-RHVLSDLEDDEVRDLGSTGT
1110 1120 1130 1140 1150 1160
1190 1200 1210 1220 1230 1240
pF1KA1 MNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQL
. .:: . :.: :. : .. ::. :: . :. ::.. .:.:::
NP_065 SSVQRQE----------VKIEESEAS--VEGFSELENSEET-RTESWELKNQISQLQEQL
1170 1180 1190 1200
1250 1260 1270
pF1KA1 MENSVVGSSREGCSSLPEIVCEDAAPEVHCDA
:
NP_065 MMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELR
1210 1220 1230 1240 1250 1260
>--
initn: 2659 init1: 2578 opt: 2945 Z-score: 1192.2 bits: 233.5 E(85289): 1.1e-59
Smith-Waterman score: 2945; 68.8% identity (80.7% similar) in 765 aa overlap (510-1245:1229-1959)
480 490 500 510 520 530
pF1KA1 NSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD--P-SSAEFFLQEERLTQM
.:: .:. :. : .: .. : : ...
NP_065 QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRE
1200 1210 1220 1230 1240 1250
540 550 560 570 580 590
pF1KA1 RNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHG---L
. ... :... . :: . .: :. :.:: . . ::: . ..: . .
NP_065 NDCLQEELRMMETRYDEALENNKELTAE--VFRLQDELKKMEEVTETFLSLEKSYDEVKI
1260 1270 1280 1290 1300 1310
600 610 620 630 640 650
pF1KA1 GSEECNPLNMSIEAELVIEQMKEQH-HRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE
.:: : : . .... ::...:. .: ::: : .... : . : .... ... :
NP_065 ENEELNVLVLRLQGK--IEKLQESVVQRCDCCL---WEASLENLEIEPDGNILQLNQTLE
1320 1330 1340 1350 1360 1370
660 670 680 690 700
pF1KA1 NMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKE--AH-----HEATCRHEEEKK-QL
. : .. :..: . :.: :.:.. .:.. :: : . :.:. . :
NP_065 ECVPRVRSVHHVIE----ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQN
1380 1390 1400 1410 1420
710 720 730 740 750 760
pF1KA1 QVKLEEEKTHL--QEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQEL
:: :::. : : :.: ..::. . : .: :. :: ::..:
NP_065 QVILEENTTLLGFQDK-HFQHQATI--------AELELEKTKLQE----------LTRKL
1430 1440 1450 1460
770 780 790 800 810
pF1KA1 EQFHQEQLTSLVEKHTL----EKEELRKELLEKHQ---RELQEG----RYESEKLQQENS
.:..: ::... . :::: : ... : :.:. ::::::::::::
NP_065 ----KERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENS
1470 1480 1490 1500 1510 1520
820 830 840 850 860 870
pF1KA1 ILRNEITTLNEEDSISNLKLGTLNGSQEEM-QKTETVKQENAAVQKMVENLKKQISELKI
:::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_065 ILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKI
1530 1540 1550 1560 1570 1580
880 890 900 910 920 930
pF1KA1 KNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEEL
1590 1600 1610 1620 1630 1640
940 950 960 970 980 990
pF1KA1 ERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISS
1650 1660 1670 1680 1690 1700
1000 1010 1020 1030 1040 1050
pF1KA1 VLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVAS
1710 1720 1730 1740 1750 1760
1060 1070 1080 1090 1100 1110
pF1KA1 QEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIAT
1770 1780 1790 1800 1810 1820
1120 1130 1140 1150 1160 1170
pF1KA1 HPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 HPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL
1830 1840 1850 1860 1870 1880
1180 1190 1200 1210 1220 1230
pF1KA1 LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENE
1890 1900 1910 1920 1930 1940
1240 1250 1260 1270
pF1KA1 GLKKKQVKLDEQLMENSVVGSSREGCSSLPEIVCEDAAPEVHCDA
:::::::::::::::
NP_065 GLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQA
1950 1960 1970 1980 1990 2000
>>XP_011535125 (OMIM: 608684,614851) PREDICTED: ninein i (2096 aa)
initn: 7541 init1: 4977 opt: 5066 Z-score: 2033.9 bits: 389.3 E(85289): 1.5e-106
Smith-Waterman score: 5121; 69.8% identity (83.6% similar) in 1232 aa overlap (30-1244:36-1214)
10 20 30 40 50
pF1KA1 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLL
:. ..::::::::::::::::::::::::
XP_011 VPRVYVVFGIHCIMAKASSDVQVSGFHRKIQHVKNELCHMLSLEEVAPVLQQTLLQDNLL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA1 GRVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KA1 FPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KA1 QDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KA1 EDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLD
250 260 270 280 290 300
300 310 320 330 340 350
pF1KA1 DGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQ
310 320 330 340 350 360
360 370 380 390 400 410
pF1KA1 AALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNL
370 380 390 400 410 420
420 430 440 450 460 470
pF1KA1 RKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKE
430 440 450 460 470 480
480 490 500 510 520 530
pF1KA1 NSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNE
490 500 510 520 530 540
540 550 560 570 580 590
pF1KA1 YERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECN
550 560 570 580 590 600
600 610 620 630 640 650
pF1KA1 PLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE
610 620 630 640 650 660
660 670 680 690 700 710
pF1KA1 NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKL
670 680 690 700 710 720
720 730 740 750 760 770
pF1KA1 RLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTL
730 740 750 760 770 780
780 790 800 810 820 830
pF1KA1 EKEELRKELLEKHQRELQEGRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQE
::::::::::::::::::::: ::.. : . ..: . . : :.
XP_011 EKEELRKELLEKHQRELQEGR---EKMETECNRRTSQIEAQFQSDC------------QK
790 800 810 820 830
840 850 860 870 880 890
pF1KA1 EMQKTETVKQE-NAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQ
.. :.. : .. .. ...:..: : : .: ..:. ::.:. .. :: :.: .
XP_011 VTERCESALQSLEGRYRQELKDLQEQQREEK---SQWEFEKDELTQECAEAQELLKETLK
840 850 860 870 880
900 910 920 930 940 950
pF1KA1 RLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIV
: :: . .:::. . . ::.:. :. . :...:: .: .:.
XP_011 R--------EKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLE-DLRNVS------
890 900 910 920 930
960 970 980 990 1000 1010
pF1KA1 QQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEK-EALSEELNSCVDKLA
. .. ::.:.. ..:. :. .: . .... . .:.: ... : : : .. ...
XP_011 ETQQSLLSDQILELKSSHK-RELRE-REEVLCQAGASEQLASQRLERLEMEHDQERQEMM
940 950 960 970 980 990
1020 1030 1040 1050 1060
pF1KA1 KSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS--------
.. : . : : .. ... : ..... : :......... ... .:
XP_011 SKLLAMENI--HKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEE
1000 1010 1020 1030 1040
1070 1080 1090 1100 1110 1120
pF1KA1 RMKSD--LRVTQQEKEALKQE---VMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSW
....: : . :: .. :... ..::.. ..: .. ..::. : :... ..:
XP_011 EVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENV--KMATEISRLQQRLQKLEP
1050 1060 1070 1080 1090 1100
1130 1140 1150 1160 1170 1180
pF1KA1 DK-LDHLMNEEQ-QLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSG
.. ..: ... . :. . ..:..... ... . :.. :.: . . :. .:
XP_011 GLVMSSCLDEPATEFFGNTAEQTEQFLQQNRTKQVEGVTR-RHVLSDLEDDEVRDLGSTG
1110 1120 1130 1140 1150 1160
1190 1200 1210 1220 1230 1240
pF1KA1 TMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQ
: . .:: . :.: :. : .. ::. :: . :. ::.. .:.::
XP_011 TSSVQRQE----------VKIEESEAS--VEGFSELENSEET-RTESWELKNQISQLQEQ
1170 1180 1190 1200 1210
1250 1260 1270
pF1KA1 LMENSVVGSSREGCSSLPEIVCEDAAPEVHCDA
::
XP_011 LMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEEL
1220 1230 1240 1250 1260 1270
>--
initn: 2627 init1: 2578 opt: 2939 Z-score: 1189.9 bits: 233.1 E(85289): 1.5e-59
Smith-Waterman score: 2939; 68.8% identity (80.6% similar) in 763 aa overlap (510-1245:1235-1965)
480 490 500 510 520 530
pF1KA1 NSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD--P-SSAEFFLQEERLTQM
.:: .:. :. : .: .. : : ...
XP_011 QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRE
1210 1220 1230 1240 1250 1260
540 550 560 570 580 590
pF1KA1 RNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE
. ... :... . :: . .: :. :.:: . . ::: . ..: . .
XP_011 NDCLQEELRMMETRYDEALENNKELTAE--VFRLQDELKKMEEVTETFLSLEKSYDEVKI
1270 1280 1290 1300 1310 1320
600 610 620 630 640 650
pF1KA1 ECNPLN-MSIEAELVIEQMKEQH-HRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENM
: . :: . .. . ::...:. .: ::: : .... : . : .... ... :.
XP_011 ENEGLNVLVLRLQGKIEKLQESVVQRCDCCL---WEASLENLEIEPDGNILQLNQTLEEC
1330 1340 1350 1360 1370
660 670 680 690 700
pF1KA1 KQRHENETHTLEKQISDLKNEIAELQGQAAVLKE--AH-----HEATCRHEEEKK-QLQV
: .. :..: . :.: :.:.. .:.. :: : . :.:. . : ::
XP_011 VPRVRSVHHVIE----ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQV
1380 1390 1400 1410 1420 1430
710 720 730 740 750 760
pF1KA1 KLEEEKTHL--QEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQ
:::. : : :.: ..::. . : .: :. :: ::..:
XP_011 ILEENTTLLGFQDK-HFQHQATI--------AELELEKTKLQE----------LTRKL--
1440 1450 1460 1470
770 780 790 800 810
pF1KA1 FHQEQLTSLVEKHTL----EKEELRKELLEKHQ---RELQEG----RYESEKLQQENSIL
.:..: ::... . :::: : ... : :.:. ::::::::::::::
XP_011 --KERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSIL
1480 1490 1500 1510 1520 1530
820 830 840 850 860 870
pF1KA1 RNEITTLNEEDSISNLKLGTLNGSQEEM-QKTETVKQENAAVQKMVENLKKQISELKIKN
:::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
XP_011 RNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKN
1540 1550 1560 1570 1580 1590
880 890 900 910 920 930
pF1KA1 QQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELER
1600 1610 1620 1630 1640 1650
940 950 960 970 980 990
pF1KA1 CKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVL
1660 1670 1680 1690 1700 1710
1000 1010 1020 1030 1040 1050
pF1KA1 SYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQE
1720 1730 1740 1750 1760 1770
1060 1070 1080 1090 1100 1110
pF1KA1 KVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHP
1780 1790 1800 1810 1820 1830
1120 1130 1140 1150 1160 1170
pF1KA1 SGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP
1840 1850 1860 1870 1880 1890
1180 1190 1200 1210 1220 1230
pF1KA1 KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGL
1900 1910 1920 1930 1940 1950
1240 1250 1260 1270
pF1KA1 KKKQVKLDEQLMENSVVGSSREGCSSLPEIVCEDAAPEVHCDA
:::::::::::::
XP_011 KKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER
1960 1970 1980 1990 2000 2010
>>XP_011535121 (OMIM: 608684,614851) PREDICTED: ninein i (2076 aa)
initn: 7752 init1: 4632 opt: 4720 Z-score: 1896.6 bits: 363.9 E(85289): 6.6e-99
Smith-Waterman score: 5275; 69.2% identity (82.2% similar) in 1291 aa overlap (1-1244:1-1238)
10 20 30 40 50 60
pF1KA1 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
10 20 30 40 50 60
70 80 90
pF1KA1 RVHFDQFKEALILILSRTLSNEEHFQEP------------------------------DC
:::::::::::::::::::::::::::: ::
XP_011 RVHFDQFKEALILILSRTLSNEEHFQEPASVGVSCQQVARVSGPLLNGHKLTHCLLIKDC
70 80 90 100 110 120
100 110 120 130 140 150
pF1KA1 SLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQ
130 140 150 160 170 180
160 170 180 190 200 210
pF1KA1 RSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSI
190 200 210 220 230 240
220 230 240 250 260 270
pF1KA1 CEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSM
250 260 270 280 290 300
280 290 300 310 320 330
pF1KA1 QSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALD
310 320 330 340 350 360
340 350 360 370 380 390
pF1KA1 FSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDL
370 380 390 400 410 420
400 410 420 430 440 450
pF1KA1 DKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGK
430 440 450 460 470 480
460 470 480 490 500 510
pF1KA1 QRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLEN
490 500 510 520 530 540
520 530 540 550 560 570
pF1KA1 VLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRL
550 560 570 580 590 600
580 590 600 610 620 630
pF1KA1 PLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELE
610 620 630 640 650 660
640 650 660 670 680 690
pF1KA1 DKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAH
670 680 690 700 710 720
700 710 720 730 740 750
pF1KA1 HEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAW
730 740 750 760 770 780
760 770 780 790 800 810
pF1KA1 TEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRYESEKLQQEN
:::::::::::::::::::::::::::::::::::::::::::::::::: ::.. :
XP_011 TEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGR---EKMETEC
790 800 810 820 830
820 830 840 850 860
pF1KA1 SILRNEITTLNEEDSISNLKLGTLNGSQEEMQKTETVKQE-NAAVQKMVENLKKQISELK
. ..: . . : :. .. :.. : .. .. ...:..: : :
XP_011 NRRTSQIEAQFQSDC------------QKVTERCESALQSLEGRYRQELKDLQEQQREEK
840 850 860 870 880
870 880 890 900 910 920
pF1KA1 IKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE
.: ..:. ::.:. .. :: :.: .: :: . .:::. . . ::.
XP_011 ---SQWEFEKDELTQECAEAQELLKETLKR--------EKTTSLVLTQEREMLEKTYKEH
890 900 910 920 930
930 940 950 960 970 980
pF1KA1 LERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKIS
:. :. . :...:: .: .:. . .. ::.:.. ..:. :. .: . ....
XP_011 LNSMVVERQQLLQDLE-DLRNVS------ETQQSLLSDQILELKSSHK-RELRE-REEVL
940 950 960 970 980
990 1000 1010 1020 1030 1040
pF1KA1 SVLSYNEKLLKEK-EALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLV
. .:.: ... : : : .. ... .. : . : : .. ... : .....
XP_011 CQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENI--HKATCETADRERAEMSTEIS
990 1000 1010 1020 1030 1040
1050 1060 1070 1080 1090
pF1KA1 ASQEKVQNLEDTVQNVNLQMS--------RMKSD--LRVTQQEKEALKQE---VMSLHKQ
: :......... ... .: ....: : . :: .. :... ..::..
XP_011 RLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRA
1050 1060 1070 1080 1090 1100
1100 1110 1120 1130 1140 1150
pF1KA1 LQNAGGKSWAPEIATHPSGLHNQQKRLSWDK-LDHLMNEEQ-QLLWQENERLQTMVQNTK
..: .. ..::. : :... ..: .. ..: ... . :. . ..:...
XP_011 HEQAVKENV--KMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEQFLQQNR
1110 1120 1130 1140 1150 1160
1160 1170 1180 1190 1200 1210
pF1KA1 AELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVS
.. ... . :.. :.: . . :. .:: . .:: . :.: :. :
XP_011 TKQVEGVTR-RHVLSDLEDDEVRDLGSTGTSSVQRQE----------VKIEESEAS--VE
1170 1180 1190 1200
1220 1230 1240 1250 1260 1270
pF1KA1 QMNSLEQELETIHLENEGLKKKQVKLDEQLMENSVVGSSREGCSSLPEIVCEDAAPEVHC
.. ::. :: . :. ::.. .:.::::
XP_011 GFSELENSEET-RTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKM
1210 1220 1230 1240 1250 1260
pF1KA1 DA
XP_011 LERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM
1270 1280 1290 1300 1310 1320
>--
initn: 2627 init1: 2578 opt: 2939 Z-score: 1190.0 bits: 233.1 E(85289): 1.5e-59
Smith-Waterman score: 2939; 68.8% identity (80.6% similar) in 763 aa overlap (510-1245:1259-1989)
480 490 500 510 520 530
pF1KA1 NSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD--P-SSAEFFLQEERLTQM
.:: .:. :. : .: .. : : ...
XP_011 QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRE
1230 1240 1250 1260 1270 1280
540 550 560 570 580 590
pF1KA1 RNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE
. ... :... . :: . .: :. :.:: . . ::: . ..: . .
XP_011 NDCLQEELRMMETRYDEALENNKELTAE--VFRLQDELKKMEEVTETFLSLEKSYDEVKI
1290 1300 1310 1320 1330 1340
600 610 620 630 640 650
pF1KA1 ECNPLN-MSIEAELVIEQMKEQH-HRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENM
: . :: . .. . ::...:. .: ::: : .... : . : .... ... :.
XP_011 ENEGLNVLVLRLQGKIEKLQESVVQRCDCCL---WEASLENLEIEPDGNILQLNQTLEEC
1350 1360 1370 1380 1390 1400
660 670 680 690 700
pF1KA1 KQRHENETHTLEKQISDLKNEIAELQGQAAVLKE--AH-----HEATCRHEEEKK-QLQV
: .. :..: . :.: :.:.. .:.. :: : . :.:. . : ::
XP_011 VPRVRSVHHVIE----ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQV
1410 1420 1430 1440 1450
710 720 730 740 750 760
pF1KA1 KLEEEKTHL--QEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQ
:::. : : :.: ..::. . : .: :. :: ::..:
XP_011 ILEENTTLLGFQDK-HFQHQATI--------AELELEKTKLQE----------LTRKL--
1460 1470 1480 1490
770 780 790 800 810
pF1KA1 FHQEQLTSLVEKHTL----EKEELRKELLEKHQ---RELQEG----RYESEKLQQENSIL
.:..: ::... . :::: : ... : :.:. ::::::::::::::
XP_011 --KERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSIL
1500 1510 1520 1530 1540 1550
820 830 840 850 860 870
pF1KA1 RNEITTLNEEDSISNLKLGTLNGSQEEM-QKTETVKQENAAVQKMVENLKKQISELKIKN
:::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
XP_011 RNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKN
1560 1570 1580 1590 1600 1610
880 890 900 910 920 930
pF1KA1 QQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELER
1620 1630 1640 1650 1660 1670
940 950 960 970 980 990
pF1KA1 CKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVL
1680 1690 1700 1710 1720 1730
1000 1010 1020 1030 1040 1050
pF1KA1 SYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQE
1740 1750 1760 1770 1780 1790
1060 1070 1080 1090 1100 1110
pF1KA1 KVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHP
1800 1810 1820 1830 1840 1850
1120 1130 1140 1150 1160 1170
pF1KA1 SGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP
1860 1870 1880 1890 1900 1910
1180 1190 1200 1210 1220 1230
pF1KA1 KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGL
1920 1930 1940 1950 1960 1970
1240 1250 1260 1270
pF1KA1 KKKQVKLDEQLMENSVVGSSREGCSSLPEIVCEDAAPEVHCDA
:::::::::::::
XP_011 KKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER
1980 1990 2000 2010 2020 2030
>>XP_011535119 (OMIM: 608684,614851) PREDICTED: ninein i (2163 aa)
initn: 7752 init1: 4632 opt: 4720 Z-score: 1896.4 bits: 363.9 E(85289): 6.8e-99
Smith-Waterman score: 5275; 69.2% identity (82.2% similar) in 1291 aa overlap (1-1244:1-1238)
10 20 30 40 50 60
pF1KA1 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
10 20 30 40 50 60
70 80 90
pF1KA1 RVHFDQFKEALILILSRTLSNEEHFQEP------------------------------DC
:::::::::::::::::::::::::::: ::
XP_011 RVHFDQFKEALILILSRTLSNEEHFQEPASVGVSCQQVARVSGPLLNGHKLTHCLLIKDC
70 80 90 100 110 120
100 110 120 130 140 150
pF1KA1 SLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQ
130 140 150 160 170 180
160 170 180 190 200 210
pF1KA1 RSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSI
190 200 210 220 230 240
220 230 240 250 260 270
pF1KA1 CEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSM
250 260 270 280 290 300
280 290 300 310 320 330
pF1KA1 QSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALD
310 320 330 340 350 360
340 350 360 370 380 390
pF1KA1 FSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDL
370 380 390 400 410 420
400 410 420 430 440 450
pF1KA1 DKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGK
430 440 450 460 470 480
460 470 480 490 500 510
pF1KA1 QRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLEN
490 500 510 520 530 540
520 530 540 550 560 570
pF1KA1 VLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRL
550 560 570 580 590 600
580 590 600 610 620 630
pF1KA1 PLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELE
610 620 630 640 650 660
640 650 660 670 680 690
pF1KA1 DKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAH
670 680 690 700 710 720
700 710 720 730 740 750
pF1KA1 HEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAW
730 740 750 760 770 780
760 770 780 790 800 810
pF1KA1 TEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRYESEKLQQEN
:::::::::::::::::::::::::::::::::::::::::::::::::: ::.. :
XP_011 TEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGR---EKMETEC
790 800 810 820 830
820 830 840 850 860
pF1KA1 SILRNEITTLNEEDSISNLKLGTLNGSQEEMQKTETVKQE-NAAVQKMVENLKKQISELK
. ..: . . : :. .. :.. : .. .. ...:..: : :
XP_011 NRRTSQIEAQFQSDC------------QKVTERCESALQSLEGRYRQELKDLQEQQREEK
840 850 860 870 880
870 880 890 900 910 920
pF1KA1 IKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE
.: ..:. ::.:. .. :: :.: .: :: . .:::. . . ::.
XP_011 ---SQWEFEKDELTQECAEAQELLKETLKR--------EKTTSLVLTQEREMLEKTYKEH
890 900 910 920 930
930 940 950 960 970 980
pF1KA1 LERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKIS
:. :. . :...:: .: .:. . .. ::.:.. ..:. :. .: . ....
XP_011 LNSMVVERQQLLQDLE-DLRNVS------ETQQSLLSDQILELKSSHK-RELRE-REEVL
940 950 960 970 980
990 1000 1010 1020 1030 1040
pF1KA1 SVLSYNEKLLKEK-EALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLV
. .:.: ... : : : .. ... .. : . : : .. ... : .....
XP_011 CQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENI--HKATCETADRERAEMSTEIS
990 1000 1010 1020 1030 1040
1050 1060 1070 1080 1090
pF1KA1 ASQEKVQNLEDTVQNVNLQMS--------RMKSD--LRVTQQEKEALKQE---VMSLHKQ
: :......... ... .: ....: : . :: .. :... ..::..
XP_011 RLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRA
1050 1060 1070 1080 1090 1100
1100 1110 1120 1130 1140 1150
pF1KA1 LQNAGGKSWAPEIATHPSGLHNQQKRLSWDK-LDHLMNEEQ-QLLWQENERLQTMVQNTK
..: .. ..::. : :... ..: .. ..: ... . :. . ..:...
XP_011 HEQAVKENV--KMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEQFLQQNR
1110 1120 1130 1140 1150 1160
1160 1170 1180 1190 1200 1210
pF1KA1 AELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVS
.. ... . :.. :.: . . :. .:: . .:: . :.: :. :
XP_011 TKQVEGVTR-RHVLSDLEDDEVRDLGSTGTSSVQRQE----------VKIEESEAS--VE
1170 1180 1190 1200
1220 1230 1240 1250 1260 1270
pF1KA1 QMNSLEQELETIHLENEGLKKKQVKLDEQLMENSVVGSSREGCSSLPEIVCEDAAPEVHC
.. ::. :: . :. ::.. .:.::::
XP_011 GFSELENSEET-RTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKM
1210 1220 1230 1240 1250 1260
pF1KA1 DA
XP_011 LERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM
1270 1280 1290 1300 1310 1320
>--
initn: 2627 init1: 2578 opt: 2939 Z-score: 1189.7 bits: 233.1 E(85289): 1.6e-59
Smith-Waterman score: 2939; 68.8% identity (80.6% similar) in 763 aa overlap (510-1245:1259-1989)
480 490 500 510 520 530
pF1KA1 NSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD--P-SSAEFFLQEERLTQM
.:: .:. :. : .: .. : : ...
XP_011 QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRE
1230 1240 1250 1260 1270 1280
540 550 560 570 580 590
pF1KA1 RNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE
. ... :... . :: . .: :. :.:: . . ::: . ..: . .
XP_011 NDCLQEELRMMETRYDEALENNKELTAE--VFRLQDELKKMEEVTETFLSLEKSYDEVKI
1290 1300 1310 1320 1330 1340
600 610 620 630 640 650
pF1KA1 ECNPLN-MSIEAELVIEQMKEQH-HRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENM
: . :: . .. . ::...:. .: ::: : .... : . : .... ... :.
XP_011 ENEGLNVLVLRLQGKIEKLQESVVQRCDCCL---WEASLENLEIEPDGNILQLNQTLEEC
1350 1360 1370 1380 1390 1400
660 670 680 690 700
pF1KA1 KQRHENETHTLEKQISDLKNEIAELQGQAAVLKE--AH-----HEATCRHEEEKK-QLQV
: .. :..: . :.: :.:.. .:.. :: : . :.:. . : ::
XP_011 VPRVRSVHHVIE----ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQV
1410 1420 1430 1440 1450
710 720 730 740 750 760
pF1KA1 KLEEEKTHL--QEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQ
:::. : : :.: ..::. . : .: :. :: ::..:
XP_011 ILEENTTLLGFQDK-HFQHQATI--------AELELEKTKLQE----------LTRKL--
1460 1470 1480 1490
770 780 790 800 810
pF1KA1 FHQEQLTSLVEKHTL----EKEELRKELLEKHQ---RELQEG----RYESEKLQQENSIL
.:..: ::... . :::: : ... : :.:. ::::::::::::::
XP_011 --KERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSIL
1500 1510 1520 1530 1540 1550
820 830 840 850 860 870
pF1KA1 RNEITTLNEEDSISNLKLGTLNGSQEEM-QKTETVKQENAAVQKMVENLKKQISELKIKN
:::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
XP_011 RNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKN
1560 1570 1580 1590 1600 1610
880 890 900 910 920 930
pF1KA1 QQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELER
1620 1630 1640 1650 1660 1670
940 950 960 970 980 990
pF1KA1 CKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVL
1680 1690 1700 1710 1720 1730
1000 1010 1020 1030 1040 1050
pF1KA1 SYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQE
1740 1750 1760 1770 1780 1790
1060 1070 1080 1090 1100 1110
pF1KA1 KVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHP
1800 1810 1820 1830 1840 1850
1120 1130 1140 1150 1160 1170
pF1KA1 SGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP
1860 1870 1880 1890 1900 1910
1180 1190 1200 1210 1220 1230
pF1KA1 KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGL
1920 1930 1940 1950 1960 1970
1240 1250 1260 1270
pF1KA1 KKKQVKLDEQLMENSVVGSSREGCSSLPEIVCEDAAPEVHCDA
:::::::::::::
XP_011 KKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER
1980 1990 2000 2010 2020 2030
>>NP_001305155 (OMIM: 609580) ninein-like protein isofor (1033 aa)
initn: 1327 init1: 654 opt: 1248 Z-score: 522.8 bits: 108.6 E(85289): 2.2e-22
Smith-Waterman score: 1636; 33.6% identity (64.8% similar) in 1064 aa overlap (1-1031:1-1021)
10 20 30 40 50 60
pF1KA1 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
::: :.... ..:.:...: :::::: : ..:::.:: : ::. ::: :::: .. ..
NP_001 MDE-EENHYVSQLREVYSSCDTTGTGFLDRQELTQLCLKLHLEQQLPVLLQTLLGNDHFA
10 20 30 40 50
70 80 90 100 110
pF1KA1 RVHFDQFKEALILILSRTL----SNEEHFQ-EPDCSLEAQPKYVRGGKRYGRRSLPEFQE
::.:..:::... .:: . :.:. . : : :::: :.: ::::: ::. .
NP_001 RVNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESAASSAIPPKYVNGSKWYGRRSRPELCD
60 70 80 90 100 110
120 130 140 150 160
pF1KA1 SVEEFPEVTVIEPLDEEARPSHI-----------PAGDC-SEHWKTQRSEEYEAEGQLRF
.. : .: : . . ::. : .: .: : ..: .::.:::.
NP_001 AATEARRVP--EQQTQASLKSHLWRSASLESVESPKSDEEAESTKEAQNELFEAQGQLQT
120 130 140 150 160 170
170 180 190 200 210 220
pF1KA1 WNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEM
:. .:... :.. :: : : ... : :.::. .:::....:. .:.. :::... :
NP_001 WDSEDFGSPQKSCSPSFDTPESQIRGVWEELGVGSSGHLSEQELAVVCQSVGLQGLEKEE
180 190 200 210 220 230
230 240 250 260 270 280
pF1KA1 LEEVFHNLDPDGT--MSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTT
::..:..:: :: .:.:.: :::.. .: .:: . : .: .::: .::
NP_001 LEDLFNKLDQDGDGKVSLEEFQLGLFSHEPALLLESSTRVKPSKAWSHYQVPEESGCHTT
240 250 260 270 280 290
290 300 310 320 330 340
pF1KA1 TSSAMTSTIG-FRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLT
:.:...: . .:.:: .::: : : ...: : .:::.:..:::..::::.: ..::
NP_001 TTSSLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDEKVNLL
300 310 320 330 340 350
350 360 370 380 390 400
pF1KA1 ELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLM
::: ::.:::... ....::::: .. :. . .:.:..::..: :.::..::: . .
NP_001 ELTWALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEF
360 370 380 390 400 410
410 420 430 440 450 460
pF1KA1 ASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIE
..:.:: :...:. .: ....:.. :.::.. :..:.. ::: . .:: .:: :: ..
NP_001 VKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVG
420 430 440 450 460 470
470 480 490 500 510 520
pF1KA1 KAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD
. ..:: .:..:.:.:::::::..:..: .:::.. : :. :::..:: :: .: :.
NP_001 RLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDK---LE
480 490 500 510 520 530
530 540 550 560 570
pF1KA1 PSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL-KNSPSEE
:.:::.. ::::.. . .::: .:: :::. ::::.::: : ::: ..:::
NP_001 PQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELE-----GLWARLPKNRHSPSW-
540 550 560 570 580
580 590 600 610 620 630
pF1KA1 VEANSGGIEPEHGLG----SEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRH
. .: . ::: : : .:::.::..::.:: :..: :: .:: :: .
NP_001 --SPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKE-HYQD---LRTQLETKVNY
590 600 610 620 630 640
640 650 660 670 680 690
pF1KA1 YEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAV--LKEAHHEA
::... . .: ...:.: .. :. .:: : .::. :. : ..: .. :.: ..
NP_001 YEREIAALKRNFEKERKDMEQARRREVSVLEGQKADLE-ELHE-KSQEVIWGLQEQLQD-
650 660 670 680 690
700 710 720 730 740 750
pF1KA1 TCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEE
: : : . :. : :. : :.:. .:. : . :.: : ... ..
NP_001 TARGPEPE---QMGLAPCCTQALCGLALRHHSHLQ----QIRLEFHRLSE--ENTLLKND
700 710 720 730 740 750
760 770 780 790 800 810
pF1KA1 --KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRYESEKLQQENS
.:: . :. :. : . .: .::. .:. : .:. :. . . .:. .
NP_001 LGRVRQELEAAESTHDAQ-RKEIEVLKKDKEKACSEM-EVLNRQNQNYKDQLSQLNVRVL
760 770 780 790 800
820 830 840 850 860 870
pF1KA1 ILRNEITTLNEEDSISNLKLGTLNGSQEEMQKTETVKQENAAVQKMVENLKKQISELKIK
: .: .: . .. . . :. : ::. .. .:.. .:: :. .. :. .
NP_001 QLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSG--QQQSDQIQK----LRVELECLNQE
810 820 830 840 850 860
880 890 900 910 920
pF1KA1 NQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKE----PGNSALEEREQEKFNLK
.:.:.: .::.: ..:...: . :: . :. .: : . . : .. ... .
NP_001 HQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGE
870 880 890 900 910 920
930 940 950 960 970 980
pF1KA1 EELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQK
. .: .: ..:.: .:. :... . ::.....:.:. . ::. :
NP_001 QARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLK
930 940 950 960 970 980
990 1000 1010 1020 1030 1040
pF1KA1 ISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL
. : .:.. .: .:: . ..: .: :::... ....
NP_001 --ELYVENAHLVRALQA-TEEKQRGAEK--QSRLLEEKVRALNKLVSRIAPAALSV
990 1000 1010 1020 1030
1050 1060 1070 1080 1090 1100
pF1KA1 VASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPE
>>XP_011527495 (OMIM: 609580) PREDICTED: ninein-like pro (1038 aa)
initn: 1188 init1: 515 opt: 1230 Z-score: 515.6 bits: 107.3 E(85289): 5.5e-22
Smith-Waterman score: 1620; 33.6% identity (64.5% similar) in 1069 aa overlap (1-1031:1-1026)
10 20 30 40 50 60
pF1KA1 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
::: :.... ..:.:...: :::::: : ..:::.:: : ::. ::: :::: .. ..
XP_011 MDE-EENHYVSQLREVYSSCDTTGTGFLDRQELTQLCLKLHLEQQLPVLLQTLLGNDHFA
10 20 30 40 50
70 80 90 100 110
pF1KA1 RVHFDQFKEALILILSRTL----SNEEHFQ-EPDCSLEAQPKYVRGGKRYGRRSLPEFQE
::.:..:::... .:: . :.:. . : : :::: :.: ::::: ::. .
XP_011 RVNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESAASSAIPPKYVNGSKWYGRRSRPELCD
60 70 80 90 100 110
120 130 140 150 160
pF1KA1 SVEEFPEVTVIEPLDEEARPSHI-----------PAGDC-SEHWKTQRSEEYEAEGQLRF
.. : .: : . . ::. : .: .: : ..: .::.:::.
XP_011 AATEARRVP--EQQTQASLKSHLWRSASLESVESPKSDEEAESTKEAQNELFEAQGQLQT
120 130 140 150 160 170
170 180 190 200 210 220
pF1KA1 WNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEM
:. .:... :.. :: : : ... : :.::. .:::....:. .:.. :::... :
XP_011 WDSEDFGSPQKSCSPSFDTPESQIRGVWEELGVGSSGHLSEQELAVVCQSVGLQGLEKEE
180 190 200 210 220 230
230 240 250 260 270 280
pF1KA1 LEEVFHNLDPDGT--MSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTT
::..:..:: :: .:.:.: :::.. .: .:: . : .: .::: .::
XP_011 LEDLFNKLDQDGDGKVSLEEFQLGLFSHEPALLLESSTRVKPSKAWSHYQVPEESGCHTT
240 250 260 270 280 290
290 300 310 320 330
pF1KA1 TSSAMTSTIG-FRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKA-----LDFSLDG
:.:...: . .:.:: .::: : : ...: : .:::.:..:::.: ::::.:
XP_011 TTSSLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQACCFQSLDFSVDE
300 310 320 330 340 350
340 350 360 370 380 390
pF1KA1 NINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEK
..:: ::: ::.:::... ....::::: .. :. . .:.:..::..: :.::..:::
XP_011 KVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEK
360 370 380 390 400 410
400 410 420 430 440 450
pF1KA1 LKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLEL
. ...:.:: :...:. .: ....:.. :.::.. :..:.. ::: . .:: .:: :
XP_011 RNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAAL
420 430 440 450 460 470
460 470 480 490 500 510
pF1KA1 EQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEK
: .. . ..:: .:..:.:.:::::::..:..: .:::.. : :. :::..:: :: .:
XP_011 EWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDK
480 490 500 510 520 530
520 530 540 550 560 570
pF1KA1 FGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL-KN
:.:.:::.. ::::.. . .::: .:: :::. ::::.::: : ::: ..
XP_011 ---LEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELE-----GLWARLPKNRH
540 550 560 570 580
580 590 600 610 620 630
pF1KA1 SPSEEVEANSGGIEPEHGLG----SEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELE
::: . .: . ::: : : .:::.::..::.:: :..: :: .::
XP_011 SPSW---SPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKE-HYQD---LRTQLE
590 600 610 620 630 640
640 650 660 670 680
pF1KA1 DKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAV--LKE
:: .::... . .: ...:.: .. :. .:: : .::. :. : ..: .. :.:
XP_011 TKVNYYEREIAALKRNFEKERKDMEQARRREVSVLEGQKADLE-ELHE-KSQEVIWGLQE
650 660 670 680 690 700
690 700 710 720 730 740
pF1KA1 AHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSS
.. : : : . :. : :. : :.:. .:. : . :.: : ...
XP_011 QLQD-TARGPEPE---QMGLAPCCTQALCGLALRHHSHLQ----QIRLEFHRLSE--ENT
710 720 730 740 750
750 760 770 780 790 800
pF1KA1 AWTEE--KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRYESEKL
.. .:: . :. :. : . .: .::. .:. : .:. :. . . .:
XP_011 LLKNDLGRVRQELEAAESTHDAQ-RKEIEVLKKDKEKACSEM-EVLNRQNQNYKDQLSQL
760 770 780 790 800
810 820 830 840 850 860
pF1KA1 QQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMQKTETVKQENAAVQKMVENLKKQIS
. . : .: .: . .. . . :. : ::. .. .:.. .:: :. ..
XP_011 NVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSG--QQQSDQIQK----LRVELE
810 820 830 840 850 860
870 880 890 900 910 920
pF1KA1 ELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKE----PGNSALEEREQE
:. ..:.:.: .::.: ..:...: . :: . :. .: : . . : ..
XP_011 CLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLL
870 880 890 900 910 920
930 940 950 960 970 980
pF1KA1 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS
... .. .: .: ..:.: .:. :... . ::.....:.:. . :
XP_011 SLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKS
930 940 950 960 970 980
990 1000 1010 1020 1030 1040
pF1KA1 DFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSAS
:. : . : .:.. .: .:: . ..: .: :::... ....
XP_011 DLLLK--ELYVENAHLVRALQA-TEEKQRGAEK--QSRLLEEKVRALNKLVSRIAPAALS
990 1000 1010 1020 1030
1050 1060 1070 1080 1090 1100
pF1KA1 LKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGK
XP_011 V
1275 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 06:51:50 2016 done: Sat Nov 5 06:51:52 2016
Total Scan time: 15.930 Total Display time: 0.860
Function used was FASTA [36.3.4 Apr, 2011]