FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1567, 861 aa 1>>>pF1KA1567 861 - 861 aa - 861 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6699+/-0.000376; mu= 19.1892+/- 0.023 mean_var=75.7227+/-15.080, 0's: 0 Z-trim(112.5): 51 B-trim: 50 in 1/49 Lambda= 0.147388 statistics sampled from 21416 (21467) to 21416 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.614), E-opt: 0.2 (0.252), width: 16 Scan time: 11.270 The best scores are: opt bits E(85289) NP_060099 (OMIM: 607356) protein argonaute-4 [Homo ( 861) 5868 1257.8 0 XP_005270636 (OMIM: 607356) PREDICTED: protein arg ( 794) 5401 1158.5 0 XP_005270635 (OMIM: 607356) PREDICTED: protein arg ( 794) 5401 1158.5 0 XP_011539185 (OMIM: 607356) PREDICTED: protein arg ( 711) 4760 1022.2 0 XP_011539186 (OMIM: 607356) PREDICTED: protein arg ( 660) 4411 948.0 0 XP_016856506 (OMIM: 606228) PREDICTED: protein arg ( 873) 4218 907.0 0 XP_016856505 (OMIM: 606228) PREDICTED: protein arg ( 876) 4203 903.8 0 NP_036331 (OMIM: 606228) protein argonaute-1 isofo ( 857) 3664 789.2 0 NP_001304051 (OMIM: 606228) protein argonaute-1 is ( 891) 3664 789.2 0 XP_011539538 (OMIM: 606228) PREDICTED: protein arg ( 860) 3648 785.8 0 NP_079128 (OMIM: 607355) protein argonaute-3 isofo ( 860) 3501 754.5 4.6e-217 XP_005270632 (OMIM: 607355) PREDICTED: protein arg ( 860) 3501 754.5 4.6e-217 XP_016856012 (OMIM: 607355) PREDICTED: protein arg ( 860) 3501 754.5 4.6e-217 XP_011539181 (OMIM: 607355) PREDICTED: protein arg ( 845) 3485 751.1 4.8e-216 XP_016856507 (OMIM: 606228) PREDICTED: protein arg ( 725) 3481 750.2 7.6e-216 NP_001158095 (OMIM: 606229) protein argonaute-2 is ( 825) 3450 743.7 8.2e-214 NP_036286 (OMIM: 606229) protein argonaute-2 isofo ( 859) 3450 743.7 8.5e-214 XP_011515267 (OMIM: 606229) PREDICTED: protein arg ( 873) 3450 743.7 8.6e-214 XP_011515270 (OMIM: 606229) PREDICTED: protein arg ( 918) 3450 743.7 9e-214 NP_001304052 (OMIM: 606228) protein argonaute-1 is ( 782) 3345 721.3 4.1e-207 XP_011515268 (OMIM: 606229) PREDICTED: protein arg ( 813) 3341 720.5 7.7e-207 XP_016868806 (OMIM: 606229) PREDICTED: protein arg ( 782) 3178 685.8 2e-196 XP_016856508 (OMIM: 606228) PREDICTED: protein arg ( 706) 2942 635.6 2.4e-181 XP_016856018 (OMIM: 607356) PREDICTED: protein arg ( 378) 2553 552.8 1.1e-156 XP_016856013 (OMIM: 607355) PREDICTED: protein arg ( 626) 2443 529.5 1.9e-149 XP_011539184 (OMIM: 607355) PREDICTED: protein arg ( 626) 2443 529.5 1.9e-149 NP_803171 (OMIM: 607355) protein argonaute-3 isofo ( 626) 2443 529.5 1.9e-149 XP_016856015 (OMIM: 607355) PREDICTED: protein arg ( 626) 2443 529.5 1.9e-149 XP_016856014 (OMIM: 607355) PREDICTED: protein arg ( 626) 2443 529.5 1.9e-149 XP_016856016 (OMIM: 607355) PREDICTED: protein arg ( 626) 2443 529.5 1.9e-149 XP_016856017 (OMIM: 607355) PREDICTED: protein arg ( 585) 2209 479.7 1.7e-134 XP_005270633 (OMIM: 607355) PREDICTED: protein arg ( 585) 2209 479.7 1.7e-134 XP_011537308 (OMIM: 605571) PREDICTED: piwi-like p ( 481) 365 87.6 1.5e-16 XP_011537304 (OMIM: 605571) PREDICTED: piwi-like p ( 861) 365 87.7 2.5e-16 NP_004755 (OMIM: 605571) piwi-like protein 1 isofo ( 861) 365 87.7 2.5e-16 XP_011537305 (OMIM: 605571) PREDICTED: piwi-like p ( 861) 365 87.7 2.5e-16 XP_011537306 (OMIM: 605571) PREDICTED: piwi-like p ( 861) 365 87.7 2.5e-16 NP_001129193 (OMIM: 610312) piwi-like protein 2 is ( 973) 356 85.8 1e-15 NP_060538 (OMIM: 610312) piwi-like protein 2 isofo ( 973) 356 85.8 1e-15 NP_689644 (OMIM: 610315) piwi-like protein 4 [Homo ( 852) 337 81.8 1.5e-14 NP_001177900 (OMIM: 605571) piwi-like protein 1 is ( 829) 324 79.0 1e-13 XP_016875718 (OMIM: 605571) PREDICTED: piwi-like p ( 832) 324 79.0 1e-13 NP_001242904 (OMIM: 610314) piwi-like protein 3 is ( 873) 295 72.8 7.7e-12 NP_001008496 (OMIM: 610314) piwi-like protein 3 is ( 882) 295 72.8 7.7e-12 NP_001317409 (OMIM: 610312) piwi-like protein 2 is ( 937) 210 54.8 2.2e-06 XP_011537307 (OMIM: 605571) PREDICTED: piwi-like p ( 819) 196 51.8 1.6e-05 XP_005273608 (OMIM: 610312) PREDICTED: piwi-like p ( 804) 181 48.6 0.00014 >>NP_060099 (OMIM: 607356) protein argonaute-4 [Homo sap (861 aa) initn: 5868 init1: 5868 opt: 5868 Z-score: 6738.0 bits: 1257.8 E(85289): 0 Smith-Waterman score: 5868; 100.0% identity (100.0% similar) in 861 aa overlap (1-861:1-861) 10 20 30 40 50 60 pF1KA1 MEALGPGPPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MEALGPGPPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 NREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 NREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 SVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 SVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 PLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 PLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 TDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 TDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 YFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 YFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATAR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 SAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 SAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 TPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 TPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 PCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 PCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 VKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 VKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 PSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 PSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 FKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 FKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 DKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 DKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 LQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 LQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRD 790 800 810 820 830 840 850 860 pF1KA1 PQALAKAVQIHHDTQHTMYFA ::::::::::::::::::::: NP_060 PQALAKAVQIHHDTQHTMYFA 850 860 >>XP_005270636 (OMIM: 607356) PREDICTED: protein argonau (794 aa) initn: 5401 init1: 5401 opt: 5401 Z-score: 6201.9 bits: 1158.5 E(85289): 0 Smith-Waterman score: 5401; 100.0% identity (100.0% similar) in 794 aa overlap (68-861:1-794) 40 50 60 70 80 90 pF1KA1 QIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLP :::::::::::::::::::::::::::::: XP_005 MVRHFKMQIFGDRQPGYDGKRNMYTAHPLP 10 20 30 100 110 120 130 140 150 pF1KA1 IGRDRVDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IGRDRVDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITR 40 50 60 70 80 90 160 170 180 190 200 210 pF1KA1 HLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRA 100 110 120 130 140 150 220 230 240 250 260 270 pF1KA1 QPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRR 160 170 180 190 200 210 280 290 300 310 320 330 pF1KA1 PASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIV 220 230 240 250 260 270 340 350 360 370 380 390 pF1KA1 AGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEM 280 290 300 310 320 330 400 410 420 430 440 450 pF1KA1 TELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCRED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCRED 340 350 360 370 380 390 460 470 480 490 500 510 pF1KA1 LLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGK 400 410 420 430 440 450 520 530 540 550 560 570 pF1KA1 TPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPS 460 470 480 490 500 510 580 590 600 610 620 630 pF1KA1 VFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYS 520 530 540 550 560 570 640 650 660 670 680 690 pF1KA1 QEVIQDLTNMVRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QEVIQDLTNMVRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLE 580 590 600 610 620 630 700 710 720 730 740 750 pF1KA1 EDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAG 640 650 660 670 680 690 760 770 780 790 800 810 pF1KA1 IQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARY 700 710 720 730 740 750 820 830 840 850 860 pF1KA1 HLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA :::::::::::::::::::::::::::::::::::::::::::: XP_005 HLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA 760 770 780 790 >>XP_005270635 (OMIM: 607356) PREDICTED: protein argonau (794 aa) initn: 5401 init1: 5401 opt: 5401 Z-score: 6201.9 bits: 1158.5 E(85289): 0 Smith-Waterman score: 5401; 100.0% identity (100.0% similar) in 794 aa overlap (68-861:1-794) 40 50 60 70 80 90 pF1KA1 QIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLP :::::::::::::::::::::::::::::: XP_005 MVRHFKMQIFGDRQPGYDGKRNMYTAHPLP 10 20 30 100 110 120 130 140 150 pF1KA1 IGRDRVDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IGRDRVDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITR 40 50 60 70 80 90 160 170 180 190 200 210 pF1KA1 HLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRA 100 110 120 130 140 150 220 230 240 250 260 270 pF1KA1 QPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRR 160 170 180 190 200 210 280 290 300 310 320 330 pF1KA1 PASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIV 220 230 240 250 260 270 340 350 360 370 380 390 pF1KA1 AGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEM 280 290 300 310 320 330 400 410 420 430 440 450 pF1KA1 TELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCRED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCRED 340 350 360 370 380 390 460 470 480 490 500 510 pF1KA1 LLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGK 400 410 420 430 440 450 520 530 540 550 560 570 pF1KA1 TPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPS 460 470 480 490 500 510 580 590 600 610 620 630 pF1KA1 VFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYS 520 530 540 550 560 570 640 650 660 670 680 690 pF1KA1 QEVIQDLTNMVRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QEVIQDLTNMVRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLE 580 590 600 610 620 630 700 710 720 730 740 750 pF1KA1 EDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAG 640 650 660 670 680 690 760 770 780 790 800 810 pF1KA1 IQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARY 700 710 720 730 740 750 820 830 840 850 860 pF1KA1 HLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA :::::::::::::::::::::::::::::::::::::::::::: XP_005 HLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA 760 770 780 790 >>XP_011539185 (OMIM: 607356) PREDICTED: protein argonau (711 aa) initn: 4760 init1: 4760 opt: 4760 Z-score: 5466.0 bits: 1022.2 E(85289): 0 Smith-Waterman score: 4760; 100.0% identity (100.0% similar) in 699 aa overlap (163-861:13-711) 140 150 160 170 180 190 pF1KA1 LLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGF :::::::::::::::::::::::::::::: XP_011 MFNVTHANSYFFRYTPVGRSFFSPPEGYYHPLGGGREVWFGF 10 20 30 40 200 210 220 230 240 250 pF1KA1 HQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEI 50 60 70 80 90 100 260 270 280 290 300 310 pF1KA1 RGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKY 110 120 130 140 150 160 320 330 340 350 360 370 pF1KA1 PHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRL 170 180 190 200 210 220 380 390 400 410 420 430 pF1KA1 VKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGK 230 240 250 260 270 280 440 450 460 470 480 490 pF1KA1 QFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADS 290 300 310 320 330 340 500 510 520 530 540 550 pF1KA1 VEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTL 350 360 370 380 390 400 560 570 580 590 600 610 pF1KA1 SNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDG 410 420 430 440 450 460 620 630 640 650 660 670 pF1KA1 HPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTRFKPTRIIYYRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTRFKPTRIIYYRGG 470 480 490 500 510 520 680 690 700 710 720 730 pF1KA1 VSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNV 530 540 550 560 570 580 740 750 760 770 780 790 pF1KA1 PAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTY 590 600 610 620 630 640 800 810 820 830 840 850 pF1KA1 VRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHH 650 660 670 680 690 700 860 pF1KA1 DTQHTMYFA ::::::::: XP_011 DTQHTMYFA 710 >>XP_011539186 (OMIM: 607356) PREDICTED: protein argonau (660 aa) initn: 4411 init1: 4411 opt: 4411 Z-score: 5065.4 bits: 948.0 E(85289): 0 Smith-Waterman score: 4411; 100.0% identity (100.0% similar) in 653 aa overlap (209-861:8-660) 180 190 200 210 220 230 pF1KA1 YHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTK :::::::::::::::::::::::::::::: XP_011 MQTLISSVSATAFYRAQPIIEFMCEVLDIQNINEQTK 10 20 30 240 250 260 270 280 290 pF1KA1 PLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTV 40 50 60 70 80 90 300 310 320 330 340 350 pF1KA1 AQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKAT 100 110 120 130 140 150 360 370 380 390 400 410 pF1KA1 ARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKT 160 170 180 190 200 210 420 430 440 450 460 470 pF1KA1 VATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQ 220 230 240 250 260 270 480 490 500 510 520 530 pF1KA1 GQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQC 280 290 300 310 320 330 540 550 560 570 580 590 pF1KA1 VQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDG 340 350 360 370 380 390 600 610 620 630 640 650 pF1KA1 KKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKS 400 410 420 430 440 450 660 670 680 690 700 710 pF1KA1 TRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLF 460 470 480 490 500 510 720 730 740 750 760 770 pF1KA1 CADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTA 520 530 540 550 560 570 780 790 800 810 820 830 pF1KA1 DELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNG 580 590 600 610 620 630 840 850 860 pF1KA1 RDPQALAKAVQIHHDTQHTMYFA ::::::::::::::::::::::: XP_011 RDPQALAKAVQIHHDTQHTMYFA 640 650 660 >>XP_016856506 (OMIM: 606228) PREDICTED: protein argonau (873 aa) initn: 2804 init1: 2121 opt: 4218 Z-score: 4841.8 bits: 907.0 E(85289): 0 Smith-Waterman score: 4883; 82.0% identity (91.8% similar) in 871 aa overlap (8-861:15-873) 10 20 30 40 50 pF1KA1 MEALGPGPP-ASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIK :: ..:: :::::.:::::::.::::.:.:.:::::::::.:::: XP_016 MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KA1 PEKRPRRVNREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGE :.: :::::::::. ::.::: ::::::.: ::::.:.::. :::: .:::.:::.::: XP_016 PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA1 GKDQTFKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFF :::. ::::..:...:: ..: :::.. :: .::::::: ::: :::::::::::: XP_016 GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA1 SPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQN :::::::::::::::::::::::::::::.:::::::::::::.:::.::::::::::.: XP_016 SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN 190 200 210 220 230 240 240 250 260 270 280 290 pF1KA1 INEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQ :.:: :::::::::.:::::.::::::::::::::::::::::::::::::::::::.:: XP_016 IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA1 AMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS ..::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA1 TMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQY ::::::::::::::::::::.:. :. . :::..:::: :...:::.::::::::.::: XP_016 TMIKATARSAPDRQEEISRLMKNASY--NLDPYIQEFGIKVKDDMTEVTGRVLPAPILQY 370 380 390 400 410 420 430 440 450 460 470 pF1KA1 GGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKD ::::...:::::::::::::::: ::::::::.:::::::::::..::.::::::::::: XP_016 GGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKD 420 430 440 450 460 470 480 490 500 510 520 530 pF1KA1 AGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLL :::::::::::::::::::::::::.::: :: :::::.::::::::::::::::::::: XP_016 AGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLL 480 490 500 510 520 530 540 550 560 570 580 590 pF1KA1 GMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTH ::::::::::::::::::::::::::::.:::::::.:::::: .::::::::::::::: XP_016 GMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTH 540 550 560 570 580 590 600 610 620 630 640 650 pF1KA1 PPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELL :::::::::::.:::::::.:::::::::::: :::: :.::. :::::: XP_016 PPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEI----------IEDLSYMVRELL 600 610 620 630 640 660 670 680 690 700 710 pF1KA1 IQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKR :::::::::::::::.:: :: :::. :. ::.::: :::.::.::.::::::::::: XP_016 IQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKR 650 660 670 680 690 700 720 730 740 750 pF1KA1 HHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQ------------- ::::::::::.::.:::::.:::::::..:::: ::::::::::::: XP_016 HHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQPSSLPSLGPLTFL 710 720 730 740 750 760 760 770 780 790 800 810 pF1KA1 ---GTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRAR :::::::: :::::: :::::::.::::::::::::::::::::::::::::::::: XP_016 SSQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRAR 770 780 790 800 810 820 820 830 840 850 860 pF1KA1 YHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA ::::::.:::.::::.:::::::::::::::::.:.:: .::::: XP_016 YHLVDKEHDSGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA 830 840 850 860 870 >>XP_016856505 (OMIM: 606228) PREDICTED: protein argonau (876 aa) initn: 4120 init1: 2121 opt: 4203 Z-score: 4824.5 bits: 903.8 E(85289): 0 Smith-Waterman score: 4867; 81.7% identity (91.5% similar) in 874 aa overlap (8-861:15-876) 10 20 30 40 50 pF1KA1 MEALGPGPP-ASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIK :: ..:: :::::.:::::::.::::.:.:.:::::::::.:::: XP_016 MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KA1 PEKRPRRVNREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGE :.: :::::::::. ::.::: ::::::.: ::::.:.::. :::: .:::.:::.::: XP_016 PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA1 GKDQTFKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFF :::. ::::..:...:: ..: :::.. :: .::::::: ::: :::::::::::: XP_016 GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA1 SPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQN :::::::::::::::::::::::::::::.:::::::::::::.:::.::::::::::.: XP_016 SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN 190 200 210 220 230 240 240 250 260 270 280 290 pF1KA1 INEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQ :.:: :::::::::.:::::.::::::::::::::::::::::::::::::::::::.:: XP_016 IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA1 AMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS ..::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA1 TMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQY ::::::::::::::::::::.:. :. . :::..:::: :...:::.::::::::.::: XP_016 TMIKATARSAPDRQEEISRLMKNASY--NLDPYIQEFGIKVKDDMTEVTGRVLPAPILQY 370 380 390 400 410 420 430 440 450 460 pF1KA1 GGR---NKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKI ::: :...:::::::::::::::: ::::::::.:::::::::::..::.:::::::: XP_016 GGRVSRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKI 420 430 440 450 460 470 470 480 490 500 510 520 pF1KA1 SKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGD ::::::::::::::::::::::::::::.::: :: :::::.:::::::::::::::::: XP_016 SKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGD 480 490 500 510 520 530 530 540 550 560 570 580 pF1KA1 TLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGAD :::::::::::::::::::::::::::::::.:::::::.:::::: .:::::::::::: XP_016 TLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGAD 540 550 560 570 580 590 590 600 610 620 630 640 pF1KA1 VTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVR ::::::::::::::.:::::::.:::::::::::: :::: :.::. ::: XP_016 VTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEI----------IEDLSYMVR 600 610 620 630 640 650 660 670 680 690 700 pF1KA1 ELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVV ::::::::::::::::::.:: :: :::. :. ::.::: :::.::.::.:::::::: XP_016 ELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVV 650 660 670 680 690 700 710 720 730 740 750 pF1KA1 QKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQ---------- :::::::::::::.::.:::::.:::::::..:::: ::::::::::::: XP_016 QKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQPSSLPSLGPL 710 720 730 740 750 760 760 770 780 790 800 810 pF1KA1 ------GTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAF :::::::: :::::: :::::::.:::::::::::::::::::::::::::::: XP_016 TFLSSQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAF 770 780 790 800 810 820 820 830 840 850 860 pF1KA1 RARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA :::::::::.:::.::::.:::::::::::::::::.:.:: .::::: XP_016 RARYHLVDKEHDSGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA 830 840 850 860 870 >>NP_036331 (OMIM: 606228) protein argonaute-1 isoform 1 (857 aa) initn: 3663 init1: 2121 opt: 3664 Z-score: 4205.3 bits: 789.2 E(85289): 0 Smith-Waterman score: 4925; 83.5% identity (93.6% similar) in 855 aa overlap (8-861:15-857) 10 20 30 40 50 pF1KA1 MEALGPGPP-ASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIK :: ..:: :::::.:::::::.::::.:.:.:::::::::.:::: NP_036 MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KA1 PEKRPRRVNREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGE :.: :::::::::. ::.::: ::::::.: ::::.:.::. :::: .:::.:::.::: NP_036 PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA1 GKDQTFKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFF :::. ::::..:...:: ..: :::.. :: .::::::: ::: :::::::::::: NP_036 GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA1 SPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQN :::::::::::::::::::::::::::::.:::::::::::::.:::.::::::::::.: NP_036 SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN 190 200 210 220 230 240 240 250 260 270 280 290 pF1KA1 INEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQ :.:: :::::::::.:::::.::::::::::::::::::::::::::::::::::::.:: NP_036 IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA1 AMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS ..::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: NP_036 TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA1 TMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQY ::::::::::::::::::::.:. :. . :::..:::: :...:::.::::::::.::: NP_036 TMIKATARSAPDRQEEISRLMKNASY--NLDPYIQEFGIKVKDDMTEVTGRVLPAPILQY 370 380 390 400 410 420 430 440 450 460 470 pF1KA1 GGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKD ::::...:::::::::::::::: ::::::::.:::::::::::..::.::::::::::: NP_036 GGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKD 420 430 440 450 460 470 480 490 500 510 520 530 pF1KA1 AGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLL :::::::::::::::::::::::::.::: :: :::::.::::::::::::::::::::: NP_036 AGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLL 480 490 500 510 520 530 540 550 560 570 580 590 pF1KA1 GMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTH ::::::::::::::::::::::::::::.:::::::.:::::: .::::::::::::::: NP_036 GMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTH 540 550 560 570 580 590 600 610 620 630 640 650 pF1KA1 PPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELL :::::::::::.:::::::.:::::::::::: :::: :.::. :::::: NP_036 PPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEI----------IEDLSYMVRELL 600 610 620 630 640 660 670 680 690 700 710 pF1KA1 IQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKR :::::::::::::::.:: :: :::. :. ::.::: :::.::.::.::::::::::: NP_036 IQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKR 650 660 670 680 690 700 720 730 740 750 760 770 pF1KA1 HHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWD ::::::::::.::.:::::.:::::::..:::: ::::::::::::::::::::: :::: NP_036 HHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWD 710 720 730 740 750 760 780 790 800 810 820 830 pF1KA1 DNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHV :: :::::::.:::::::::::::::::::::::::::::::::::::::.:::.::::. NP_036 DNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHI 770 780 790 800 810 820 840 850 860 pF1KA1 SGQSNGRDPQALAKAVQIHHDTQHTMYFA :::::::::::::::::.:.:: .::::: NP_036 SGQSNGRDPQALAKAVQVHQDTLRTMYFA 830 840 850 >>NP_001304051 (OMIM: 606228) protein argonaute-1 isofor (891 aa) initn: 3663 init1: 2121 opt: 3664 Z-score: 4205.0 bits: 789.2 E(85289): 0 Smith-Waterman score: 4925; 83.5% identity (93.6% similar) in 855 aa overlap (8-861:15-857) 10 20 30 40 50 pF1KA1 MEALGPGPP-ASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIK :: ..:: :::::.:::::::.::::.:.:.:::::::::.:::: NP_001 MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KA1 PEKRPRRVNREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGE :.: :::::::::. ::.::: ::::::.: ::::.:.::. :::: .:::.:::.::: NP_001 PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA1 GKDQTFKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFF :::. ::::..:...:: ..: :::.. :: .::::::: ::: :::::::::::: NP_001 GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA1 SPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQN :::::::::::::::::::::::::::::.:::::::::::::.:::.::::::::::.: NP_001 SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN 190 200 210 220 230 240 240 250 260 270 280 290 pF1KA1 INEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQ :.:: :::::::::.:::::.::::::::::::::::::::::::::::::::::::.:: NP_001 IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA1 AMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS ..::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA1 TMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQY ::::::::::::::::::::.:. :. . :::..:::: :...:::.::::::::.::: NP_001 TMIKATARSAPDRQEEISRLMKNASY--NLDPYIQEFGIKVKDDMTEVTGRVLPAPILQY 370 380 390 400 410 420 430 440 450 460 470 pF1KA1 GGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKD ::::...:::::::::::::::: ::::::::.:::::::::::..::.::::::::::: NP_001 GGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKD 420 430 440 450 460 470 480 490 500 510 520 530 pF1KA1 AGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLL :::::::::::::::::::::::::.::: :: :::::.::::::::::::::::::::: NP_001 AGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLL 480 490 500 510 520 530 540 550 560 570 580 590 pF1KA1 GMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTH ::::::::::::::::::::::::::::.:::::::.:::::: .::::::::::::::: NP_001 GMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTH 540 550 560 570 580 590 600 610 620 630 640 650 pF1KA1 PPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELL :::::::::::.:::::::.:::::::::::: :::: :.::. :::::: NP_001 PPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEI----------IEDLSYMVRELL 600 610 620 630 640 660 670 680 690 700 710 pF1KA1 IQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKR :::::::::::::::.:: :: :::. :. ::.::: :::.::.::.::::::::::: NP_001 IQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKR 650 660 670 680 690 700 720 730 740 750 760 770 pF1KA1 HHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWD ::::::::::.::.:::::.:::::::..:::: ::::::::::::::::::::: :::: NP_001 HHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWD 710 720 730 740 750 760 780 790 800 810 820 830 pF1KA1 DNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHV :: :::::::.:::::::::::::::::::::::::::::::::::::::.:::.::::. NP_001 DNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHI 770 780 790 800 810 820 840 850 860 pF1KA1 SGQSNGRDPQALAKAVQIHHDTQHTMYFA :::::::::::::::::.:.:: .::::: NP_001 SGQSNGRDPQALAKAVQVHQDTLRTMYFAXRQNAVTSLDRRKLSKPQELCHPNPEEARRR 830 840 850 860 870 880 >>XP_011539538 (OMIM: 606228) PREDICTED: protein argonau (860 aa) initn: 3488 init1: 2121 opt: 3648 Z-score: 4186.9 bits: 785.8 E(85289): 0 Smith-Waterman score: 4909; 83.2% identity (93.2% similar) in 858 aa overlap (8-861:15-860) 10 20 30 40 50 pF1KA1 MEALGPGPP-ASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIK :: ..:: :::::.:::::::.::::.:.:.:::::::::.:::: XP_011 MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KA1 PEKRPRRVNREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGE :.: :::::::::. ::.::: ::::::.: ::::.:.::. :::: .:::.:::.::: XP_011 PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA1 GKDQTFKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFF :::. ::::..:...:: ..: :::.. :: .::::::: ::: :::::::::::: XP_011 GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA1 SPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQN :::::::::::::::::::::::::::::.:::::::::::::.:::.::::::::::.: XP_011 SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN 190 200 210 220 230 240 240 250 260 270 280 290 pF1KA1 INEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQ :.:: :::::::::.:::::.::::::::::::::::::::::::::::::::::::.:: XP_011 IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA1 AMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS ..::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA1 TMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQY ::::::::::::::::::::.:. :. . :::..:::: :...:::.::::::::.::: XP_011 TMIKATARSAPDRQEEISRLMKNASY--NLDPYIQEFGIKVKDDMTEVTGRVLPAPILQY 370 380 390 400 410 420 430 440 450 460 pF1KA1 GGR---NKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKI ::: :...:::::::::::::::: ::::::::.:::::::::::..::.:::::::: XP_011 GGRVSRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKI 420 430 440 450 460 470 470 480 490 500 510 520 pF1KA1 SKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGD ::::::::::::::::::::::::::::.::: :: :::::.:::::::::::::::::: XP_011 SKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGD 480 490 500 510 520 530 530 540 550 560 570 580 pF1KA1 TLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGAD :::::::::::::::::::::::::::::::.:::::::.:::::: .:::::::::::: XP_011 TLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGAD 540 550 560 570 580 590 590 600 610 620 630 640 pF1KA1 VTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVR ::::::::::::::.:::::::.:::::::::::: :::: :.::. ::: XP_011 VTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEI----------IEDLSYMVR 600 610 620 630 640 650 660 670 680 690 700 pF1KA1 ELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVV ::::::::::::::::::.:: :: :::. :. ::.::: :::.::.::.:::::::: XP_011 ELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVV 650 660 670 680 690 700 710 720 730 740 750 760 pF1KA1 QKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQV :::::::::::::.::.:::::.:::::::..:::: ::::::::::::::::::::: : XP_011 QKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYV 710 720 730 740 750 760 770 780 790 800 810 820 pF1KA1 LWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEG ::::: :::::::.:::::::::::::::::::::::::::::::::::::::.:::.:: XP_011 LWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEG 770 780 790 800 810 820 830 840 850 860 pF1KA1 SHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA ::.:::::::::::::::::.:.:: .::::: XP_011 SHISGQSNGRDPQALAKAVQVHQDTLRTMYFA 830 840 850 860 861 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 01:38:34 2016 done: Fri Nov 4 01:38:36 2016 Total Scan time: 11.270 Total Display time: 0.290 Function used was FASTA [36.3.4 Apr, 2011]