FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1598, 631 aa 1>>>pF1KA1598 631 - 631 aa - 631 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.8318+/-0.000445; mu= -17.4049+/- 0.028 mean_var=556.7016+/-113.978, 0's: 0 Z-trim(123.6): 8 B-trim: 0 in 0/61 Lambda= 0.054358 statistics sampled from 43580 (43608) to 43580 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.771), E-opt: 0.2 (0.511), width: 16 Scan time: 9.560 The best scores are: opt bits E(85289) NP_001120683 (OMIM: 611171) shootin-1 isoform a [H ( 631) 4025 330.4 1.2e-89 NP_001245227 (OMIM: 611171) shootin-1 isoform c [H ( 571) 3647 300.7 9e-81 XP_016871951 (OMIM: 611171) PREDICTED: shootin-1 i ( 571) 3647 300.7 9e-81 NP_001245228 (OMIM: 611171) shootin-1 isoform d [H ( 558) 3528 291.4 5.7e-78 XP_005270059 (OMIM: 611171) PREDICTED: shootin-1 i ( 573) 3528 291.4 5.8e-78 XP_006717994 (OMIM: 611171) PREDICTED: shootin-1 i ( 617) 3528 291.4 6.2e-78 NP_001245229 (OMIM: 611171) shootin-1 isoform e [H ( 498) 3150 261.7 4.4e-69 NP_060800 (OMIM: 611171) shootin-1 isoform b [Homo ( 456) 2878 240.4 1.1e-62 >>NP_001120683 (OMIM: 611171) shootin-1 isoform a [Homo (631 aa) initn: 4025 init1: 4025 opt: 4025 Z-score: 1730.7 bits: 330.4 E(85289): 1.2e-89 Smith-Waterman score: 4025; 100.0% identity (100.0% similar) in 631 aa overlap (1-631:1-631) 10 20 30 40 50 60 pF1KA1 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 PLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 VHLRPVNQTARPKTKPESSKGCESAVDELKGILGTLNKSTSSRSLKSLDPENSETELERI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHLRPVNQTARPKTKPESSKGCESAVDELKGILGTLNKSTSSRSLKSLDPENSETELERI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 LRRRKVTAEADSSSPTGILATSESKSMPVLGSVSSVTKTALNKKTLEAEFNSPSPPTPEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRRRKVTAEADSSSPTGILATSESKSMPVLGSVSSVTKTALNKKTLEAEFNSPSPPTPEP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 GEGPRKLEGCTSSKVTFQPPSSIGCRKKYIDGEKQAEPVVVLDPVSTHEPQTKDQVAEKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEGPRKLEGCTSSKVTFQPPSSIGCRKKYIDGEKQAEPVVVLDPVSTHEPQTKDQVAEKD 550 560 570 580 590 600 610 620 630 pF1KA1 PTQHKEDEGEIQPENKEDSIENVRETDSSNC ::::::::::::::::::::::::::::::: NP_001 PTQHKEDEGEIQPENKEDSIENVRETDSSNC 610 620 630 >>NP_001245227 (OMIM: 611171) shootin-1 isoform c [Homo (571 aa) initn: 3647 init1: 3647 opt: 3647 Z-score: 1571.1 bits: 300.7 E(85289): 9e-81 Smith-Waterman score: 3647; 100.0% identity (100.0% similar) in 571 aa overlap (61-631:1-571) 40 50 60 70 80 90 pF1KA1 NQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKL :::::::::::::::::::::::::::::: NP_001 MVIEEVNFMQNHLEIEKTCRESAEALATKL 10 20 30 100 110 120 130 140 150 pF1KA1 NKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQ 40 50 60 70 80 90 160 170 180 190 200 210 pF1KA1 IVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLA 100 110 120 130 140 150 220 230 240 250 260 270 pF1KA1 VEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENA 160 170 180 190 200 210 280 290 300 310 320 330 pF1KA1 KLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEK 220 230 240 250 260 270 340 350 360 370 380 390 pF1KA1 ARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKK 280 290 300 310 320 330 400 410 420 430 440 450 pF1KA1 EKATQPETTEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKTKPESSKGCESAVDELK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKATQPETTEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKTKPESSKGCESAVDELK 340 350 360 370 380 390 460 470 480 490 500 510 pF1KA1 GILGTLNKSTSSRSLKSLDPENSETELERILRRRKVTAEADSSSPTGILATSESKSMPVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GILGTLNKSTSSRSLKSLDPENSETELERILRRRKVTAEADSSSPTGILATSESKSMPVL 400 410 420 430 440 450 520 530 540 550 560 570 pF1KA1 GSVSSVTKTALNKKTLEAEFNSPSPPTPEPGEGPRKLEGCTSSKVTFQPPSSIGCRKKYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSVSSVTKTALNKKTLEAEFNSPSPPTPEPGEGPRKLEGCTSSKVTFQPPSSIGCRKKYI 460 470 480 490 500 510 580 590 600 610 620 630 pF1KA1 DGEKQAEPVVVLDPVSTHEPQTKDQVAEKDPTQHKEDEGEIQPENKEDSIENVRETDSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGEKQAEPVVVLDPVSTHEPQTKDQVAEKDPTQHKEDEGEIQPENKEDSIENVRETDSSN 520 530 540 550 560 570 pF1KA1 C : NP_001 C >>XP_016871951 (OMIM: 611171) PREDICTED: shootin-1 isofo (571 aa) initn: 3647 init1: 3647 opt: 3647 Z-score: 1571.1 bits: 300.7 E(85289): 9e-81 Smith-Waterman score: 3647; 100.0% identity (100.0% similar) in 571 aa overlap (61-631:1-571) 40 50 60 70 80 90 pF1KA1 NQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKL :::::::::::::::::::::::::::::: XP_016 MVIEEVNFMQNHLEIEKTCRESAEALATKL 10 20 30 100 110 120 130 140 150 pF1KA1 NKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQ 40 50 60 70 80 90 160 170 180 190 200 210 pF1KA1 IVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLA 100 110 120 130 140 150 220 230 240 250 260 270 pF1KA1 VEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENA 160 170 180 190 200 210 280 290 300 310 320 330 pF1KA1 KLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEK 220 230 240 250 260 270 340 350 360 370 380 390 pF1KA1 ARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKK 280 290 300 310 320 330 400 410 420 430 440 450 pF1KA1 EKATQPETTEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKTKPESSKGCESAVDELK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKATQPETTEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKTKPESSKGCESAVDELK 340 350 360 370 380 390 460 470 480 490 500 510 pF1KA1 GILGTLNKSTSSRSLKSLDPENSETELERILRRRKVTAEADSSSPTGILATSESKSMPVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GILGTLNKSTSSRSLKSLDPENSETELERILRRRKVTAEADSSSPTGILATSESKSMPVL 400 410 420 430 440 450 520 530 540 550 560 570 pF1KA1 GSVSSVTKTALNKKTLEAEFNSPSPPTPEPGEGPRKLEGCTSSKVTFQPPSSIGCRKKYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSVSSVTKTALNKKTLEAEFNSPSPPTPEPGEGPRKLEGCTSSKVTFQPPSSIGCRKKYI 460 470 480 490 500 510 580 590 600 610 620 630 pF1KA1 DGEKQAEPVVVLDPVSTHEPQTKDQVAEKDPTQHKEDEGEIQPENKEDSIENVRETDSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGEKQAEPVVVLDPVSTHEPQTKDQVAEKDPTQHKEDEGEIQPENKEDSIENVRETDSSN 520 530 540 550 560 570 pF1KA1 C : XP_016 C >>NP_001245228 (OMIM: 611171) shootin-1 isoform d [Homo (558 aa) initn: 3528 init1: 3528 opt: 3528 Z-score: 1520.8 bits: 291.4 E(85289): 5.7e-78 Smith-Waterman score: 3528; 100.0% identity (100.0% similar) in 558 aa overlap (1-558:1-558) 10 20 30 40 50 60 pF1KA1 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 PLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 VHLRPVNQTARPKTKPESSKGCESAVDELKGILGTLNKSTSSRSLKSLDPENSETELERI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHLRPVNQTARPKTKPESSKGCESAVDELKGILGTLNKSTSSRSLKSLDPENSETELERI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 LRRRKVTAEADSSSPTGILATSESKSMPVLGSVSSVTKTALNKKTLEAEFNSPSPPTPEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRRRKVTAEADSSSPTGILATSESKSMPVLGSVSSVTKTALNKKTLEAEFNSPSPPTPEP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 GEGPRKLEGCTSSKVTFQPPSSIGCRKKYIDGEKQAEPVVVLDPVSTHEPQTKDQVAEKD :::::::::::::::::: NP_001 GEGPRKLEGCTSSKVTFQ 550 >>XP_005270059 (OMIM: 611171) PREDICTED: shootin-1 isofo (573 aa) initn: 3528 init1: 3528 opt: 3528 Z-score: 1520.6 bits: 291.4 E(85289): 5.8e-78 Smith-Waterman score: 3528; 100.0% identity (100.0% similar) in 558 aa overlap (1-558:1-558) 10 20 30 40 50 60 pF1KA1 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 PLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 VHLRPVNQTARPKTKPESSKGCESAVDELKGILGTLNKSTSSRSLKSLDPENSETELERI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VHLRPVNQTARPKTKPESSKGCESAVDELKGILGTLNKSTSSRSLKSLDPENSETELERI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 LRRRKVTAEADSSSPTGILATSESKSMPVLGSVSSVTKTALNKKTLEAEFNSPSPPTPEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LRRRKVTAEADSSSPTGILATSESKSMPVLGSVSSVTKTALNKKTLEAEFNSPSPPTPEP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 GEGPRKLEGCTSSKVTFQPPSSIGCRKKYIDGEKQAEPVVVLDPVSTHEPQTKDQVAEKD :::::::::::::::::: XP_005 GEGPRKLEGCTSSKVTFQEILIGSPVNSLLLFI 550 560 570 >>XP_006717994 (OMIM: 611171) PREDICTED: shootin-1 isofo (617 aa) initn: 3528 init1: 3528 opt: 3528 Z-score: 1520.2 bits: 291.4 E(85289): 6.2e-78 Smith-Waterman score: 3528; 100.0% identity (100.0% similar) in 558 aa overlap (1-558:1-558) 10 20 30 40 50 60 pF1KA1 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 PLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 VHLRPVNQTARPKTKPESSKGCESAVDELKGILGTLNKSTSSRSLKSLDPENSETELERI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VHLRPVNQTARPKTKPESSKGCESAVDELKGILGTLNKSTSSRSLKSLDPENSETELERI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 LRRRKVTAEADSSSPTGILATSESKSMPVLGSVSSVTKTALNKKTLEAEFNSPSPPTPEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LRRRKVTAEADSSSPTGILATSESKSMPVLGSVSSVTKTALNKKTLEAEFNSPSPPTPEP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 GEGPRKLEGCTSSKVTFQPPSSIGCRKKYIDGEKQAEPVVVLDPVSTHEPQTKDQVAEKD :::::::::::::::::: XP_006 GEGPRKLEGCTSSKVTFQFMSFQFNQHPCIAAVEPREHFLEIFSPELMKKAFSRICAPPL 550 560 570 580 590 600 >>NP_001245229 (OMIM: 611171) shootin-1 isoform e [Homo (498 aa) initn: 3150 init1: 3150 opt: 3150 Z-score: 1361.3 bits: 261.7 E(85289): 4.4e-69 Smith-Waterman score: 3150; 100.0% identity (100.0% similar) in 498 aa overlap (61-558:1-498) 40 50 60 70 80 90 pF1KA1 NQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKL :::::::::::::::::::::::::::::: NP_001 MVIEEVNFMQNHLEIEKTCRESAEALATKL 10 20 30 100 110 120 130 140 150 pF1KA1 NKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQ 40 50 60 70 80 90 160 170 180 190 200 210 pF1KA1 IVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLA 100 110 120 130 140 150 220 230 240 250 260 270 pF1KA1 VEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENA 160 170 180 190 200 210 280 290 300 310 320 330 pF1KA1 KLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEK 220 230 240 250 260 270 340 350 360 370 380 390 pF1KA1 ARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKK 280 290 300 310 320 330 400 410 420 430 440 450 pF1KA1 EKATQPETTEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKTKPESSKGCESAVDELK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKATQPETTEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKTKPESSKGCESAVDELK 340 350 360 370 380 390 460 470 480 490 500 510 pF1KA1 GILGTLNKSTSSRSLKSLDPENSETELERILRRRKVTAEADSSSPTGILATSESKSMPVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GILGTLNKSTSSRSLKSLDPENSETELERILRRRKVTAEADSSSPTGILATSESKSMPVL 400 410 420 430 440 450 520 530 540 550 560 570 pF1KA1 GSVSSVTKTALNKKTLEAEFNSPSPPTPEPGEGPRKLEGCTSSKVTFQPPSSIGCRKKYI :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSVSSVTKTALNKKTLEAEFNSPSPPTPEPGEGPRKLEGCTSSKVTFQ 460 470 480 490 580 590 600 610 620 630 pF1KA1 DGEKQAEPVVVLDPVSTHEPQTKDQVAEKDPTQHKEDEGEIQPENKEDSIENVRETDSSN >>NP_060800 (OMIM: 611171) shootin-1 isoform b [Homo sap (456 aa) initn: 3100 init1: 2878 opt: 2878 Z-score: 1246.5 bits: 240.4 E(85289): 1.1e-62 Smith-Waterman score: 2878; 99.6% identity (100.0% similar) in 455 aa overlap (1-455:1-455) 10 20 30 40 50 60 pF1KA1 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 PLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 PLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 VHLRPVNQTARPKTKPESSKGCESAVDELKGILGTLNKSTSSRSLKSLDPENSETELERI :::::::::::::::::::::::::::::::::.. NP_060 VHLRPVNQTARPKTKPESSKGCESAVDELKGILASQ 430 440 450 490 500 510 520 530 540 pF1KA1 LRRRKVTAEADSSSPTGILATSESKSMPVLGSVSSVTKTALNKKTLEAEFNSPSPPTPEP 631 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 21:31:36 2016 done: Wed Nov 2 21:31:37 2016 Total Scan time: 9.560 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]