Result of FASTA (omim) for
pF1KA1643
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1643, 886 aa
1>>>pF1KA1643 886 - 886 aa - 886 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.5636+/-0.000344; mu= 7.6547+/- 0.022
mean_var=194.8005+/-39.277, 0's: 0 Z-trim(121.3): 174 B-trim: 0 in 0/55
Lambda= 0.091892
statistics sampled from 37453 (37640) to 37453 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.756), E-opt: 0.2 (0.441), width: 16
Scan time: 15.090
The best scores are: opt bits E(85289)
NP_066023 (OMIM: 614176) lateral signaling target ( 887) 6015 810.3 0
XP_006713963 (OMIM: 614176) PREDICTED: lateral sig (1044) 5709 769.8 0
NP_001166130 (OMIM: 614176) lateral signaling targ ( 817) 5545 748.0 4.3e-215
XP_016863994 (OMIM: 614176) PREDICTED: lateral sig ( 773) 5222 705.1 3.2e-202
XP_016863993 (OMIM: 614176) PREDICTED: lateral sig ( 937) 5201 702.4 2.5e-201
XP_016863992 (OMIM: 614176) PREDICTED: lateral sig ( 939) 5201 702.4 2.5e-201
XP_006713965 (OMIM: 614176) PREDICTED: lateral sig ( 938) 5191 701.1 6.4e-201
XP_011511843 (OMIM: 614176) PREDICTED: lateral sig ( 754) 4969 671.6 3.9e-192
XP_016863991 (OMIM: 614176) PREDICTED: lateral sig ( 986) 4967 671.4 5.8e-192
XP_011511842 (OMIM: 614176) PREDICTED: lateral sig ( 930) 4916 664.6 6e-190
XP_016863998 (OMIM: 614176) PREDICTED: lateral sig ( 691) 4618 625.0 3.7e-178
XP_016863997 (OMIM: 614176) PREDICTED: lateral sig ( 703) 4614 624.5 5.4e-178
XP_016863996 (OMIM: 614176) PREDICTED: lateral sig ( 715) 4606 623.4 1.1e-177
XP_016863999 (OMIM: 614176) PREDICTED: lateral sig ( 689) 4602 622.9 1.6e-177
XP_016863995 (OMIM: 614176) PREDICTED: lateral sig ( 761) 4602 622.9 1.7e-177
NP_001166127 (OMIM: 614176) lateral signaling targ ( 857) 4446 602.3 3.2e-171
NP_001166128 (OMIM: 614176) lateral signaling targ ( 287) 1573 221.1 6.1e-57
XP_006713967 (OMIM: 614176) PREDICTED: lateral sig ( 233) 1556 218.7 2.5e-56
NP_001166131 (OMIM: 614176) lateral signaling targ ( 163) 1086 156.3 1.1e-37
NP_001166129 (OMIM: 614176) lateral signaling targ ( 172) 958 139.4 1.4e-32
XP_016884521 (OMIM: 603558) PREDICTED: myotubulari (1161) 347 59.0 1.6e-07
NP_694691 (OMIM: 603558) myotubularin-related prot (1161) 347 59.0 1.6e-07
XP_005261865 (OMIM: 603558) PREDICTED: myotubulari (1174) 347 59.0 1.6e-07
XP_016884520 (OMIM: 603558) PREDICTED: myotubulari (1207) 347 59.0 1.6e-07
NP_076976 (OMIM: 613504) zinc finger FYVE domain-c ( 234) 279 49.5 2.3e-05
NP_001185882 (OMIM: 613504) zinc finger FYVE domai ( 252) 279 49.5 2.4e-05
XP_016865384 (OMIM: 610327) PREDICTED: RUN and FYV ( 310) 267 47.9 8.6e-05
NP_775829 (OMIM: 605091) FYVE, RhoGEF and PH domai ( 655) 273 49.0 8.9e-05
XP_016865383 (OMIM: 610327) PREDICTED: RUN and FYV ( 368) 267 48.0 9.9e-05
XP_006714985 (OMIM: 610327) PREDICTED: RUN and FYV ( 368) 267 48.0 9.9e-05
XP_016865382 (OMIM: 610327) PREDICTED: RUN and FYV ( 416) 267 48.0 0.00011
XP_016865381 (OMIM: 610327) PREDICTED: RUN and FYV ( 438) 267 48.1 0.00011
XP_005266050 (OMIM: 610327) PREDICTED: RUN and FYV ( 465) 267 48.1 0.00012
XP_016865380 (OMIM: 610327) PREDICTED: RUN and FYV ( 578) 267 48.1 0.00014
NP_066576 (OMIM: 603558) myotubularin-related prot (1198) 273 49.2 0.00014
NP_001035541 (OMIM: 610327) RUN and FYVE domain-co ( 600) 267 48.2 0.00014
NP_001035542 (OMIM: 610327) RUN and FYVE domain-co ( 600) 267 48.2 0.00014
XP_005261862 (OMIM: 603558) PREDICTED: myotubulari (1211) 273 49.2 0.00015
XP_016884518 (OMIM: 603558) PREDICTED: myotubulari (1244) 273 49.2 0.00015
XP_006714984 (OMIM: 610327) PREDICTED: RUN and FYV ( 686) 267 48.2 0.00016
NP_079434 (OMIM: 610327) RUN and FYVE domain-conta ( 708) 267 48.2 0.00017
NP_001171471 (OMIM: 121850,609414) 1-phosphatidyli ( 548) 260 47.2 0.00026
XP_016865918 (OMIM: 605091) PREDICTED: FYVE, RhoGE ( 662) 259 47.1 0.00033
XP_016880786 (OMIM: 604375) PREDICTED: hepatocyte ( 768) 260 47.3 0.00033
NP_004703 (OMIM: 604375) hepatocyte growth factor- ( 777) 260 47.3 0.00034
XP_011523765 (OMIM: 604375) PREDICTED: hepatocyte ( 777) 260 47.3 0.00034
NP_060821 (OMIM: 613520) FYVE, RhoGEF and PH domai (1430) 264 48.0 0.00038
XP_005259313 (OMIM: 615200) PREDICTED: pleckstrin ( 364) 250 45.7 0.00047
XP_011509094 (OMIM: 121850,609414) PREDICTED: 1-ph (1340) 260 47.5 0.00052
XP_011525611 (OMIM: 615200) PREDICTED: pleckstrin ( 279) 244 44.9 0.00066
>>NP_066023 (OMIM: 614176) lateral signaling target prot (887 aa)
initn: 6015 init1: 6015 opt: 6015 Z-score: 4318.9 bits: 810.3 E(85289): 0
Smith-Waterman score: 6015; 99.9% identity (99.9% similar) in 886 aa overlap (1-886:2-887)
10 20 30 40 50
pF1KA1 MNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRKDPQRCTLLVSQFRSCQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 MMNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRKDPQRCTLLVSQFRSCQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA1 DNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 DNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KA1 SMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMV
130 140 150 160 170 180
180 190 200 210 220 230
pF1KA1 PVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 PVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KA1 DGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 DGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KA1 QGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 QGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLL
310 320 330 340 350 360
360 370 380 390 400 410
pF1KA1 SPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPA
370 380 390 400 410 420
420 430 440 450 460 470
pF1KA1 GPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 GPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCS
430 440 450 460 470 480
480 490 500 510 520 530
pF1KA1 CLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 CLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEP
490 500 510 520 530 540
540 550 560 570 580 590
pF1KA1 VAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 VAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLA
550 560 570 580 590 600
600 610 620 630 640 650
pF1KA1 KASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 KASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQE
610 620 630 640 650 660
660 670 680 690 700 710
pF1KA1 PEARELHAGSPPAHEAPQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRF
::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 PEARELHAGSPSAHEAPQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRF
670 680 690 700 710 720
720 730 740 750 760 770
pF1KA1 HGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 HGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLR
730 740 750 760 770 780
780 790 800 810 820 830
pF1KA1 SAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCR
790 800 810 820 830 840
840 850 860 870 880
pF1KA1 SCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPFYSDKAGL
:::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPFYSDKAGL
850 860 870 880
>>XP_006713963 (OMIM: 614176) PREDICTED: lateral signali (1044 aa)
initn: 5731 init1: 5698 opt: 5709 Z-score: 4098.6 bits: 769.8 E(85289): 0
Smith-Waterman score: 5709; 98.3% identity (98.8% similar) in 862 aa overlap (1-861:2-863)
10 20 30 40 50
pF1KA1 MNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRKDPQRCTLLVSQFRSCQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MMNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRKDPQRCTLLVSQFRSCQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA1 DNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KA1 SMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMV
130 140 150 160 170 180
180 190 200 210 220 230
pF1KA1 PVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KA1 DGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KA1 QGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLL
310 320 330 340 350 360
360 370 380 390 400 410
pF1KA1 SPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPA
370 380 390 400 410 420
420 430 440 450 460 470
pF1KA1 GPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCS
430 440 450 460 470 480
480 490 500 510 520 530
pF1KA1 CLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEP
490 500 510 520 530 540
540 550 560 570 580 590
pF1KA1 VAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLA
550 560 570 580 590 600
600 610 620 630 640 650
pF1KA1 KASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQE
610 620 630 640 650 660
660 670 680 690 700 710
pF1KA1 PEARELHAGSPPAHEAPQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRF
::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PEARELHAGSPSAHEAPQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRF
670 680 690 700 710 720
720 730 740 750 760 770
pF1KA1 HGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLR
730 740 750 760 770 780
780 790 800 810 820 830
pF1KA1 SAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCR
790 800 810 820 830 840
840 850 860 870 880
pF1KA1 SCGKIFCSRCS-SHSAPLPRYGQVKPVRVCTHCYMFHVTPFYSDKAGL
::::. . :. . :: .::
XP_006 SCGKVGETPCTEGPSASKGVHGQSLRSGSQNRCPGRPARPVGSCAEAPGGPGPCSDSRHL
850 860 870 880 890 900
>>NP_001166130 (OMIM: 614176) lateral signaling target p (817 aa)
initn: 5545 init1: 5545 opt: 5545 Z-score: 3982.6 bits: 748.0 E(85289): 4.3e-215
Smith-Waterman score: 5545; 99.9% identity (99.9% similar) in 817 aa overlap (70-886:1-817)
40 50 60 70 80 90
pF1KA1 DGRKDPQRCTLLVSQFRSCQDNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQ
::::::::::::::::::::::::::::::
NP_001 MDECIPQDRAPRDFCVKFPEEIRHDNLAGQ
10 20 30
100 110 120 130 140 150
pF1KA1 LWFGAECLAAGSIIMNRELESMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWFGAECLAAGSIIMNRELESMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREA
40 50 60 70 80 90
160 170 180 190 200 210
pF1KA1 LRHFDVLFAEFELSYVSAMVPVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRHFDVLFAEFELSYVSAMVPVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYE
100 110 120 130 140 150
220 230 240 250 260 270
pF1KA1 PALMFSIPRLAIVCGLVVYADGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PALMFSIPRLAIVCGLVVYADGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELH
160 170 180 190 200 210
280 290 300 310 320 330
pF1KA1 TLERNLCISQDVEFPIRADVQGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLERNLCISQDVEFPIRADVQGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQ
220 230 240 250 260 270
340 350 360 370 380 390
pF1KA1 ELEQLSRMVHRAGDEMSSLLSPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELEQLSRMVHRAGDEMSSLLSPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERV
280 290 300 310 320 330
400 410 420 430 440 450
pF1KA1 FFMDDVEGTAEALARPESPAGPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFMDDVEGTAEALARPESPAGPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSN
340 350 360 370 380 390
460 470 480 490 500 510
pF1KA1 NNLEAEGTDGASLAGTSSCSCLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NNLEAEGTDGASLAGTSSCSCLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFN
400 410 420 430 440 450
520 530 540 550 560 570
pF1KA1 PKSPTSLDSAVATQEAASEPVAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKSPTSLDSAVATQEAASEPVAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVER
460 470 480 490 500 510
580 590 600 610 620 630
pF1KA1 LREKCSPGGVIGASYAAGLAKASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LREKCSPGGVIGASYAAGLAKASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSG
520 530 540 550 560 570
640 650 660 670 680 690
pF1KA1 SQVDTASGLQGEAGVAGQQEPEARELHAGSPPAHEAPQALSGSSSSTAGSCSSDKMGPEA
::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
NP_001 SQVDTASGLQGEAGVAGQQEPEARELHAGSPSAHEAPQALSGSSSSTAGSCSSDKMGPEA
580 590 600 610 620 630
700 710 720 730 740 750
pF1KA1 APAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVM
640 650 660 670 680 690
760 770 780 790 800 810
pF1KA1 ATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEAC
700 710 720 730 740 750
820 830 840 850 860 870
pF1KA1 GFCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPF
760 770 780 790 800 810
880
pF1KA1 YSDKAGL
:::::::
NP_001 YSDKAGL
>>XP_016863994 (OMIM: 614176) PREDICTED: lateral signali (773 aa)
initn: 5222 init1: 5222 opt: 5222 Z-score: 3751.6 bits: 705.1 E(85289): 3.2e-202
Smith-Waterman score: 5222; 99.9% identity (99.9% similar) in 773 aa overlap (114-886:1-773)
90 100 110 120 130 140
pF1KA1 CVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELESMAMRPLAKELTRSLEDVRGALRD
::::::::::::::::::::::::::::::
XP_016 MNRELESMAMRPLAKELTRSLEDVRGALRD
10 20 30
150 160 170 180 190 200
pF1KA1 QALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMVPVKSPREYYVQQEVIVLFCETVER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMVPVKSPREYYVQQEVIVLFCETVER
40 50 60 70 80 90
210 220 230 240 250 260
pF1KA1 ALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYADGPLNLDRKVEDMSELFRPFHTLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYADGPLNLDRKVEDMSELFRPFHTLL
100 110 120 130 140 150
270 280 290 300 310 320
pF1KA1 RKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADVQGPAALAPALSAPLPPEGPLSAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADVQGPAALAPALSAPLPPEGPLSAKA
160 170 180 190 200 210
330 340 350 360 370 380
pF1KA1 KDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLLSPPIACQSPAHRPGAEGSPGGEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLLSPPIACQSPAHRPGAEGSPGGEAS
220 230 240 250 260 270
390 400 410 420 430 440
pF1KA1 PGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPAGPFGWAGSTWADPQEKGQGGPGGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPAGPFGWAGSTWADPQEKGQGGPGGA
280 290 300 310 320 330
450 460 470 480 490 500
pF1KA1 AGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCSCLDSRLHLDGWEVGADDAETAEMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCSCLDSRLHLDGWEVGADDAETAEMI
340 350 360 370 380 390
510 520 530 540 550 560
pF1KA1 AHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEPVAEGMDGGPHKLSTGATNCLLHSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEPVAEGMDGGPHKLSTGATNCLLHSC
400 410 420 430 440 450
570 580 590 600 610 620
pF1KA1 VCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLAKASDRAPERQEEAPPPSEDASNGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLAKASDRAPERQEEAPPPSEDASNGR
460 470 480 490 500 510
630 640 650 660 670 680
pF1KA1 EPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQEPEARELHAGSPPAHEAPQALSGSS
::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_016 EPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQEPEARELHAGSPSAHEAPQALSGSS
520 530 540 550 560 570
690 700 710 720 730 740
pF1KA1 SSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTN
580 590 600 610 620 630
750 760 770 780 790 800
pF1KA1 YASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTR
640 650 660 670 680 690
810 820 830 840 850 860
pF1KA1 DGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVK
700 710 720 730 740 750
870 880
pF1KA1 PVRVCTHCYMFHVTPFYSDKAGL
:::::::::::::::::::::::
XP_016 PVRVCTHCYMFHVTPFYSDKAGL
760 770
>>XP_016863993 (OMIM: 614176) PREDICTED: lateral signali (937 aa)
initn: 5234 init1: 5201 opt: 5201 Z-score: 3735.3 bits: 702.4 E(85289): 2.5e-201
Smith-Waterman score: 5215; 90.0% identity (92.3% similar) in 887 aa overlap (1-866:2-887)
10 20 30 40 50
pF1KA1 MNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRKDPQRCTLLVSQFRSCQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MMNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRKDPQRCTLLVSQFRSCQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA1 DNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KA1 SMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMV
130 140 150 160 170 180
180 190 200 210 220 230
pF1KA1 PVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KA1 DGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KA1 QGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLL
310 320 330 340 350 360
360 370 380 390 400 410
pF1KA1 SPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPA
370 380 390 400 410 420
420 430 440 450 460 470
pF1KA1 GPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCS
430 440 450 460 470 480
480 490 500 510 520 530
pF1KA1 CLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEP
490 500 510 520 530 540
540 550 560 570 580 590
pF1KA1 VAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLA
550 560 570 580 590 600
600 610 620 630 640 650
pF1KA1 KASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQE
610 620 630 640 650 660
660 670 680 690 700 710
pF1KA1 PEARELHAGSPPAHEAPQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRF
::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEARELHAGSPSAHEAPQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRF
670 680 690 700 710 720
720 730 740 750 760 770
pF1KA1 HGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::. .:
XP_016 HGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKAEPSLT
730 740 750 760 770 780
780 790 800 810 820
pF1KA1 SAALEDCA---LCQETLSSSELAAKTRDGDFEDP---PEWV---PDEACGFCTA----CK
. : : . : . : : : .. :.: : . : . .: . :
XP_016 TEASVHGASGHMGQPAWSWSPGPAGHTLASREEPMCRPSSALPNPHRQAAFYQGGWQDCL
790 800 810 820 830 840
830 840 850 860 870
pF1KA1 APFTVIRRKHHCRSCG-----KIFCSRCSSHS---APLPRYGQVKPVRVCTHCYMFHVTP
. .:.:.. : :: . :.: : : : .: .: :
XP_016 LEI-MIQRRQSPRLCGVRPWRTVHCARRPCHPLNWQPRPAMGTLKTPRSGCQTRPVASAR
850 860 870 880 890
880
pF1KA1 FYSDKAGL
XP_016 RAKHPSPSSAGSTTAAAVGRSSARAAPRTQHRCPATGR
900 910 920 930
>>XP_016863992 (OMIM: 614176) PREDICTED: lateral signali (939 aa)
initn: 5234 init1: 5201 opt: 5201 Z-score: 3735.3 bits: 702.4 E(85289): 2.5e-201
Smith-Waterman score: 5215; 90.0% identity (92.3% similar) in 887 aa overlap (1-866:2-887)
10 20 30 40 50
pF1KA1 MNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRKDPQRCTLLVSQFRSCQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MMNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRKDPQRCTLLVSQFRSCQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA1 DNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KA1 SMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMV
130 140 150 160 170 180
180 190 200 210 220 230
pF1KA1 PVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KA1 DGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KA1 QGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLL
310 320 330 340 350 360
360 370 380 390 400 410
pF1KA1 SPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPA
370 380 390 400 410 420
420 430 440 450 460 470
pF1KA1 GPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCS
430 440 450 460 470 480
480 490 500 510 520 530
pF1KA1 CLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEP
490 500 510 520 530 540
540 550 560 570 580 590
pF1KA1 VAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLA
550 560 570 580 590 600
600 610 620 630 640 650
pF1KA1 KASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQE
610 620 630 640 650 660
660 670 680 690 700 710
pF1KA1 PEARELHAGSPPAHEAPQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRF
::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEARELHAGSPSAHEAPQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRF
670 680 690 700 710 720
720 730 740 750 760 770
pF1KA1 HGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::. .:
XP_016 HGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKAEPSLT
730 740 750 760 770 780
780 790 800 810 820
pF1KA1 SAALEDCA---LCQETLSSSELAAKTRDGDFEDP---PEWV---PDEACGFCTA----CK
. : : . : . : : : .. :.: : . : . .: . :
XP_016 TEASVHGASGHMGQPAWSWSPGPAGHTLASREEPMCRPSSALPNPHRQAAFYQGGWQDCL
790 800 810 820 830 840
830 840 850 860 870
pF1KA1 APFTVIRRKHHCRSCG-----KIFCSRCSSHS---APLPRYGQVKPVRVCTHCYMFHVTP
. .:.:.. : :: . :.: : : : .: .: :
XP_016 LEI-MIQRRQSPRLCGVRPWRTVHCARRPCHPLNWQPRPAMGTLKTPRSGCQTRPVASAR
850 860 870 880 890
880
pF1KA1 FYSDKAGL
XP_016 RAKHPSPSSAGSTTAAAVGRWVRPLARRVPQHPRASTDRA
900 910 920 930
>>XP_006713965 (OMIM: 614176) PREDICTED: lateral signali (938 aa)
initn: 5191 init1: 5191 opt: 5191 Z-score: 3728.2 bits: 701.1 E(85289): 6.4e-201
Smith-Waterman score: 5210; 89.8% identity (92.4% similar) in 886 aa overlap (1-866:2-886)
10 20 30 40 50
pF1KA1 MNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRKDPQRCTLLVSQFRSCQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MMNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRKDPQRCTLLVSQFRSCQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA1 DNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KA1 SMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMV
130 140 150 160 170 180
180 190 200 210 220 230
pF1KA1 PVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KA1 DGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KA1 QGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLL
310 320 330 340 350 360
360 370 380 390 400 410
pF1KA1 SPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPA
370 380 390 400 410 420
420 430 440 450 460 470
pF1KA1 GPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCS
430 440 450 460 470 480
480 490 500 510 520 530
pF1KA1 CLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEP
490 500 510 520 530 540
540 550 560 570 580 590
pF1KA1 VAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLA
550 560 570 580 590 600
600 610 620 630 640 650
pF1KA1 KASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQE
610 620 630 640 650 660
660 670 680 690 700 710
pF1KA1 PEARELHAGSPPAHEAPQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRF
::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PEARELHAGSPSAHEAPQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRF
670 680 690 700 710 720
720 730 740 750 760 770
pF1KA1 HGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLR
:::::::::::::::::::::::::::::::::::::::::::::::::::::: .
XP_006 HGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKEPSLTT
730 740 750 760 770 780
780 790 800 810 820
pF1KA1 SAALEDCA--LCQETLSSSELAAKTRDGDFEDP---PEWV---PDEACGFCTA----CKA
:... . . : . : : : .. :.: : . : . .: . :
XP_006 EASVHGASGHMGQPAWSWSPGPAGHTLASREEPMCRPSSALPNPHRQAAFYQGGWQDCLL
790 800 810 820 830 840
830 840 850 860 870
pF1KA1 PFTVIRRKHHCRSCG-----KIFCSRCSSHS---APLPRYGQVKPVRVCTHCYMFHVTPF
. .:.:.. : :: . :.: : : : .: .: :
XP_006 EI-MIQRRQSPRLCGVRPWRTVHCARRPCHPLNWQPRPAMGTLKTPRSGCQTRPVASARR
850 860 870 880 890
880
pF1KA1 YSDKAGL
XP_006 AKHPSPSSAGSTTAAAVGRWVRPLARRVPQHPRASTDRA
900 910 920 930
>>XP_011511843 (OMIM: 614176) PREDICTED: lateral signali (754 aa)
initn: 4963 init1: 4963 opt: 4969 Z-score: 3570.4 bits: 671.6 E(85289): 3.9e-192
Smith-Waterman score: 4969; 98.1% identity (98.8% similar) in 753 aa overlap (1-752:2-754)
10 20 30 40 50
pF1KA1 MNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRKDPQRCTLLVSQFRSCQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MMNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRKDPQRCTLLVSQFRSCQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA1 DNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KA1 SMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMV
130 140 150 160 170 180
180 190 200 210 220 230
pF1KA1 PVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KA1 DGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KA1 QGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLL
310 320 330 340 350 360
360 370 380 390 400 410
pF1KA1 SPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPA
370 380 390 400 410 420
420 430 440 450 460 470
pF1KA1 GPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCS
430 440 450 460 470 480
480 490 500 510 520 530
pF1KA1 CLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEP
490 500 510 520 530 540
540 550 560 570 580 590
pF1KA1 VAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLA
550 560 570 580 590 600
600 610 620 630 640 650
pF1KA1 KASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQE
610 620 630 640 650 660
660 670 680 690 700 710
pF1KA1 PEARELHAGSPPAHEAPQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRF
::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEARELHAGSPSAHEAPQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRF
670 680 690 700 710 720
720 730 740 750 760 770
pF1KA1 HGSHDLIHRLFVCISGVADQLQTN-YASDLRSILKTLFEVMATKPETDDKEKLRKVTQTL
::::::::::::::::: . .:. . : :. :
XP_011 HGSHDLIHRLFVCISGVMSGPETGAWLEDTRAAL
730 740 750
780 790 800 810 820 830
pF1KA1 RSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHC
>>XP_016863991 (OMIM: 614176) PREDICTED: lateral signali (986 aa)
initn: 4989 init1: 4956 opt: 4967 Z-score: 3567.4 bits: 671.4 E(85289): 5.8e-192
Smith-Waterman score: 4967; 98.0% identity (98.7% similar) in 757 aa overlap (106-861:49-805)
80 90 100 110 120 130
pF1KA1 QDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELESMAMRPLAKELTRSLE
::::::::::::::::::::::::::::::
XP_016 GDIGYRPHDCSECKKNLLRGPGTRAGLCCGCLAAGSIIMNRELESMAMRPLAKELTRSLE
20 30 40 50 60 70
140 150 160 170 180 190
pF1KA1 DVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMVPVKSPREYYVQQEVIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMVPVKSPREYYVQQEVIV
80 90 100 110 120 130
200 210 220 230 240 250
pF1KA1 LFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYADGPLNLDRKVEDMSEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYADGPLNLDRKVEDMSEL
140 150 160 170 180 190
260 270 280 290 300 310
pF1KA1 FRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADVQGPAALAPALSAPLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADVQGPAALAPALSAPLPP
200 210 220 230 240 250
320 330 340 350 360 370
pF1KA1 EGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLLSPPIACQSPAHRPGAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLLSPPIACQSPAHRPGAE
260 270 280 290 300 310
380 390 400 410 420 430
pF1KA1 GSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPAGPFGWAGSTWADPQEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPAGPFGWAGSTWADPQEK
320 330 340 350 360 370
440 450 460 470 480 490
pF1KA1 GQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCSCLDSRLHLDGWEVGAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCSCLDSRLHLDGWEVGAD
380 390 400 410 420 430
500 510 520 530 540 550
pF1KA1 DAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEPVAEGMDGGPHKLSTGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEPVAEGMDGGPHKLSTGA
440 450 460 470 480 490
560 570 580 590 600 610
pF1KA1 TNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLAKASDRAPERQEEAPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLAKASDRAPERQEEAPPP
500 510 520 530 540 550
620 630 640 650 660 670
pF1KA1 SEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQEPEARELHAGSPPAHEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_016 SEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQEPEARELHAGSPSAHEA
560 570 580 590 600 610
680 690 700 710 720 730
pF1KA1 PQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISG
620 630 640 650 660 670
740 750 760 770 780 790
pF1KA1 VADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSS
680 690 700 710 720 730
800 810 820 830 840 850
pF1KA1 SELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSRCS-SHSA
::::::::::::::::::::::::::::::::::::::::::::::::. . :. . ::
XP_016 SELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKVGETPCTEGPSA
740 750 760 770 780 790
860 870 880
pF1KA1 PLPRYGQVKPVRVCTHCYMFHVTPFYSDKAGL
.::
XP_016 SKGVHGQSLRSGSQNRCPGRPARPVGSCAEAPGGPGPCSDSRHLTTGTWMVPMSSPGCCR
800 810 820 830 840 850
>>XP_011511842 (OMIM: 614176) PREDICTED: lateral signali (930 aa)
initn: 4938 init1: 4905 opt: 4916 Z-score: 3531.2 bits: 664.6 E(85289): 6e-190
Smith-Waterman score: 4916; 98.0% identity (98.7% similar) in 749 aa overlap (114-861:1-749)
90 100 110 120 130 140
pF1KA1 CVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELESMAMRPLAKELTRSLEDVRGALRD
::::::::::::::::::::::::::::::
XP_011 MNRELESMAMRPLAKELTRSLEDVRGALRD
10 20 30
150 160 170 180 190 200
pF1KA1 QALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMVPVKSPREYYVQQEVIVLFCETVER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMVPVKSPREYYVQQEVIVLFCETVER
40 50 60 70 80 90
210 220 230 240 250 260
pF1KA1 ALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYADGPLNLDRKVEDMSELFRPFHTLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYADGPLNLDRKVEDMSELFRPFHTLL
100 110 120 130 140 150
270 280 290 300 310 320
pF1KA1 RKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADVQGPAALAPALSAPLPPEGPLSAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADVQGPAALAPALSAPLPPEGPLSAKA
160 170 180 190 200 210
330 340 350 360 370 380
pF1KA1 KDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLLSPPIACQSPAHRPGAEGSPGGEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLLSPPIACQSPAHRPGAEGSPGGEAS
220 230 240 250 260 270
390 400 410 420 430 440
pF1KA1 PGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPAGPFGWAGSTWADPQEKGQGGPGGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPAGPFGWAGSTWADPQEKGQGGPGGA
280 290 300 310 320 330
450 460 470 480 490 500
pF1KA1 AGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCSCLDSRLHLDGWEVGADDAETAEMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCSCLDSRLHLDGWEVGADDAETAEMI
340 350 360 370 380 390
510 520 530 540 550 560
pF1KA1 AHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEPVAEGMDGGPHKLSTGATNCLLHSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEPVAEGMDGGPHKLSTGATNCLLHSC
400 410 420 430 440 450
570 580 590 600 610 620
pF1KA1 VCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLAKASDRAPERQEEAPPPSEDASNGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLAKASDRAPERQEEAPPPSEDASNGR
460 470 480 490 500 510
630 640 650 660 670 680
pF1KA1 EPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQEPEARELHAGSPPAHEAPQALSGSS
::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_011 EPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQEPEARELHAGSPSAHEAPQALSGSS
520 530 540 550 560 570
690 700 710 720 730 740
pF1KA1 SSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTN
580 590 600 610 620 630
750 760 770 780 790 800
pF1KA1 YASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTR
640 650 660 670 680 690
810 820 830 840 850 860
pF1KA1 DGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSRCS-SHSAPLPRYGQV
::::::::::::::::::::::::::::::::::::::::. . :. . :: .::
XP_011 DGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKVGETPCTEGPSASKGVHGQS
700 710 720 730 740 750
870 880
pF1KA1 KPVRVCTHCYMFHVTPFYSDKAGL
XP_011 LRSGSQNRCPGRPARPVGSCAEAPGGPGPCSDSRHLTTGTWMVPMSSPGCCRASHREGTA
760 770 780 790 800 810
886 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 06:53:18 2016 done: Sat Nov 5 06:53:20 2016
Total Scan time: 15.090 Total Display time: 0.310
Function used was FASTA [36.3.4 Apr, 2011]