FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1645, 327 aa 1>>>pF1KA1645 327 - 327 aa - 327 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1280+/-0.000298; mu= 13.5806+/- 0.019 mean_var=122.6517+/-25.415, 0's: 0 Z-trim(120.0): 144 B-trim: 1838 in 1/51 Lambda= 0.115808 statistics sampled from 34583 (34768) to 34583 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.742), E-opt: 0.2 (0.408), width: 16 Scan time: 5.730 The best scores are: opt bits E(85289) NP_443730 (OMIM: 610778) guanine nucleotide-bindin ( 327) 2279 391.4 1.4e-108 XP_016878352 (OMIM: 602703,616212) PREDICTED: kata ( 655) 209 45.8 0.00029 NP_005877 (OMIM: 602703,616212) katanin p80 WD40 r ( 655) 209 45.8 0.00029 XP_016878353 (OMIM: 602703,616212) PREDICTED: kata ( 655) 209 45.8 0.00029 XP_006721186 (OMIM: 602703,616212) PREDICTED: kata ( 658) 209 45.8 0.00029 XP_005255829 (OMIM: 602703,616212) PREDICTED: kata ( 672) 209 45.9 0.00029 XP_016878351 (OMIM: 602703,616212) PREDICTED: kata ( 672) 209 45.9 0.00029 XP_016878350 (OMIM: 602703,616212) PREDICTED: kata ( 672) 209 45.9 0.00029 XP_016878349 (OMIM: 602703,616212) PREDICTED: kata ( 675) 209 45.9 0.00029 XP_006721184 (OMIM: 602703,616212) PREDICTED: kata ( 675) 209 45.9 0.00029 XP_006721185 (OMIM: 602703,616212) PREDICTED: kata ( 675) 209 45.9 0.00029 XP_011521112 (OMIM: 602703,616212) PREDICTED: kata ( 675) 209 45.9 0.00029 NP_008882 (OMIM: 601787) transcription initiation ( 800) 204 45.1 0.00059 NP_006089 (OMIM: 176981) receptor of activated pro ( 317) 194 43.0 0.00098 NP_004362 (OMIM: 601924,616414) coatomer subunit a (1224) 200 44.6 0.0013 NP_001091868 (OMIM: 601924,616414) coatomer subuni (1233) 200 44.6 0.0013 NP_006444 (OMIM: 605915) transducin beta-like prot ( 808) 189 42.6 0.0034 NP_001271359 (OMIM: 616194) U3 small nucleolar RNA ( 499) 182 41.2 0.0054 NP_115551 (OMIM: 616194) U3 small nucleolar RNA-as ( 518) 182 41.2 0.0056 XP_011541982 (OMIM: 616194) PREDICTED: U3 small nu ( 518) 182 41.2 0.0056 XP_016865757 (OMIM: 604586) PREDICTED: syntaxin-bi ( 746) 184 41.7 0.0057 XP_016880191 (OMIM: 601545,607432) PREDICTED: plat ( 345) 179 40.6 0.0059 XP_016880190 (OMIM: 601545,607432) PREDICTED: plat ( 410) 179 40.6 0.0067 XP_016880188 (OMIM: 601545,607432) PREDICTED: plat ( 410) 179 40.6 0.0067 NP_000421 (OMIM: 601545,607432) platelet-activatin ( 410) 179 40.6 0.0067 XP_016880189 (OMIM: 601545,607432) PREDICTED: plat ( 410) 179 40.6 0.0067 XP_011522204 (OMIM: 601545,607432) PREDICTED: plat ( 428) 179 40.7 0.0069 XP_011522205 (OMIM: 601545,607432) PREDICTED: plat ( 428) 179 40.7 0.0069 XP_011522203 (OMIM: 601545,607432) PREDICTED: plat ( 428) 179 40.7 0.0069 NP_001273573 (OMIM: 608067) E3 ubiquitin-protein l ( 491) 179 40.7 0.0076 XP_016857565 (OMIM: 608067) PREDICTED: E3 ubiquiti ( 491) 179 40.7 0.0076 NP_640337 (OMIM: 604586) syntaxin-binding protein (1115) 184 41.9 0.0076 XP_016857564 (OMIM: 608067) PREDICTED: E3 ubiquiti ( 497) 179 40.7 0.0077 XP_006715402 (OMIM: 604586) PREDICTED: syntaxin-bi (1135) 184 41.9 0.0077 NP_001121187 (OMIM: 604586) syntaxin-binding prote (1151) 184 41.9 0.0078 XP_011525181 (OMIM: 614767) PREDICTED: striatin-4 ( 365) 176 40.1 0.0087 XP_016879922 (OMIM: 610091) PREDICTED: WD repeat a ( 383) 176 40.1 0.009 NP_056441 (OMIM: 610091) WD repeat and SOCS box-co ( 421) 176 40.1 0.0096 NP_001001740 (OMIM: 608067) E3 ubiquitin-protein l ( 707) 179 40.9 0.0098 XP_006711550 (OMIM: 608067) PREDICTED: E3 ubiquiti ( 708) 179 40.9 0.0098 XP_005245505 (OMIM: 608067) PREDICTED: E3 ubiquiti ( 711) 179 40.9 0.0099 >>NP_443730 (OMIM: 610778) guanine nucleotide-binding pr (327 aa) initn: 2279 init1: 2279 opt: 2279 Z-score: 2070.5 bits: 391.4 E(85289): 1.4e-108 Smith-Waterman score: 2279; 100.0% identity (100.0% similar) in 327 aa overlap (1-327:1-327) 10 20 30 40 50 60 pF1KA1 MTAPCPPPPPDPQFVLRGTQSPVHALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 MTAPCPPPPPDPQFVLRGTQSPVHALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 TTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAEGRSAVVDSVCLESVGFCRSSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 TTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAEGRSAVVDSVCLESVGFCRSSI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 LAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKADAKLGMPMCLRLWQADCSSRPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 LAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKADAKLGMPMCLRLWQADCSSRPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 LLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 LLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDWQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 QALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 QALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQC 250 260 270 280 290 300 310 320 pF1KA1 VAFTADGLLAAGSKDQRISLWSLYPRA ::::::::::::::::::::::::::: NP_443 VAFTADGLLAAGSKDQRISLWSLYPRA 310 320 >>XP_016878352 (OMIM: 602703,616212) PREDICTED: katanin (655 aa) initn: 188 init1: 111 opt: 209 Z-score: 197.6 bits: 45.8 E(85289): 0.00029 Smith-Waterman score: 209; 27.4% identity (58.2% similar) in 146 aa overlap (180-323:77-218) 150 160 170 180 190 200 pF1KA1 SVCALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEE :..:: ..::. .::. :. . :. XP_016 LWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKA 50 60 70 80 90 100 210 220 230 240 250 260 pF1KA1 PVMDLDFDSQKARGISGSAGKALAVWSLDWQQ-ALQVRGTHELTNPGIAEVTIRPDRKIL . .::: ::: . .:.. . ... :: : . .. . . :: : : XP_016 NICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRG-H---SQAVRCLRFSPDGKWL 110 120 130 140 150 160 270 280 290 300 310 320 pF1KA1 ATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAF-TADGLLAAGSKDQRISLWSLYPRA :.:. :: .... . . .. . :.. :. : : . :::.::.:. : .:.: XP_016 ASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQ 170 180 190 200 210 220 XP_016 VVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICN 230 240 250 260 270 280 >>NP_005877 (OMIM: 602703,616212) katanin p80 WD40 repea (655 aa) initn: 188 init1: 111 opt: 209 Z-score: 197.6 bits: 45.8 E(85289): 0.00029 Smith-Waterman score: 209; 27.4% identity (58.2% similar) in 146 aa overlap (180-323:77-218) 150 160 170 180 190 200 pF1KA1 SVCALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEE :..:: ..::. .::. :. . :. NP_005 LWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKA 50 60 70 80 90 100 210 220 230 240 250 260 pF1KA1 PVMDLDFDSQKARGISGSAGKALAVWSLDWQQ-ALQVRGTHELTNPGIAEVTIRPDRKIL . .::: ::: . .:.. . ... :: : . .. . . :: : : NP_005 NICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRG-H---SQAVRCLRFSPDGKWL 110 120 130 140 150 160 270 280 290 300 310 320 pF1KA1 ATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAF-TADGLLAAGSKDQRISLWSLYPRA :.:. :: .... . . .. . :.. :. : : . :::.::.:. : .:.: NP_005 ASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQ 170 180 190 200 210 220 NP_005 VVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICN 230 240 250 260 270 280 >>XP_016878353 (OMIM: 602703,616212) PREDICTED: katanin (655 aa) initn: 188 init1: 111 opt: 209 Z-score: 197.6 bits: 45.8 E(85289): 0.00029 Smith-Waterman score: 209; 27.4% identity (58.2% similar) in 146 aa overlap (180-323:77-218) 150 160 170 180 190 200 pF1KA1 SVCALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEE :..:: ..::. .::. :. . :. XP_016 LWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKA 50 60 70 80 90 100 210 220 230 240 250 260 pF1KA1 PVMDLDFDSQKARGISGSAGKALAVWSLDWQQ-ALQVRGTHELTNPGIAEVTIRPDRKIL . .::: ::: . .:.. . ... :: : . .. . . :: : : XP_016 NICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRG-H---SQAVRCLRFSPDGKWL 110 120 130 140 150 160 270 280 290 300 310 320 pF1KA1 ATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAF-TADGLLAAGSKDQRISLWSLYPRA :.:. :: .... . . .. . :.. :. : : . :::.::.:. : .:.: XP_016 ASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQ 170 180 190 200 210 220 XP_016 VVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICN 230 240 250 260 270 280 >>XP_006721186 (OMIM: 602703,616212) PREDICTED: katanin (658 aa) initn: 265 init1: 111 opt: 209 Z-score: 197.5 bits: 45.8 E(85289): 0.00029 Smith-Waterman score: 209; 27.4% identity (58.2% similar) in 146 aa overlap (180-323:77-218) 150 160 170 180 190 200 pF1KA1 SVCALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEE :..:: ..::. .::. :. . :. XP_006 LWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKA 50 60 70 80 90 100 210 220 230 240 250 260 pF1KA1 PVMDLDFDSQKARGISGSAGKALAVWSLDWQQ-ALQVRGTHELTNPGIAEVTIRPDRKIL . .::: ::: . .:.. . ... :: : . .. . . :: : : XP_006 NICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRG-H---SQAVRCLRFSPDGKWL 110 120 130 140 150 160 270 280 290 300 310 320 pF1KA1 ATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAF-TADGLLAAGSKDQRISLWSLYPRA :.:. :: .... . . .. . :.. :. : : . :::.::.:. : .:.: XP_006 ASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQ 170 180 190 200 210 220 XP_006 VVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICN 230 240 250 260 270 280 >>XP_005255829 (OMIM: 602703,616212) PREDICTED: katanin (672 aa) initn: 188 init1: 111 opt: 209 Z-score: 197.4 bits: 45.9 E(85289): 0.00029 Smith-Waterman score: 209; 27.4% identity (58.2% similar) in 146 aa overlap (180-323:77-218) 150 160 170 180 190 200 pF1KA1 SVCALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEE :..:: ..::. .::. :. . :. XP_005 LWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKA 50 60 70 80 90 100 210 220 230 240 250 260 pF1KA1 PVMDLDFDSQKARGISGSAGKALAVWSLDWQQ-ALQVRGTHELTNPGIAEVTIRPDRKIL . .::: ::: . .:.. . ... :: : . .. . . :: : : XP_005 NICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRG-H---SQAVRCLRFSPDGKWL 110 120 130 140 150 160 270 280 290 300 310 320 pF1KA1 ATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAF-TADGLLAAGSKDQRISLWSLYPRA :.:. :: .... . . .. . :.. :. : : . :::.::.:. : .:.: XP_005 ASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQ 170 180 190 200 210 220 XP_005 VVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICN 230 240 250 260 270 280 >>XP_016878351 (OMIM: 602703,616212) PREDICTED: katanin (672 aa) initn: 188 init1: 111 opt: 209 Z-score: 197.4 bits: 45.9 E(85289): 0.00029 Smith-Waterman score: 209; 27.4% identity (58.2% similar) in 146 aa overlap (180-323:77-218) 150 160 170 180 190 200 pF1KA1 SVCALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEE :..:: ..::. .::. :. . :. XP_016 LWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKA 50 60 70 80 90 100 210 220 230 240 250 260 pF1KA1 PVMDLDFDSQKARGISGSAGKALAVWSLDWQQ-ALQVRGTHELTNPGIAEVTIRPDRKIL . .::: ::: . .:.. . ... :: : . .. . . :: : : XP_016 NICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRG-H---SQAVRCLRFSPDGKWL 110 120 130 140 150 160 270 280 290 300 310 320 pF1KA1 ATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAF-TADGLLAAGSKDQRISLWSLYPRA :.:. :: .... . . .. . :.. :. : : . :::.::.:. : .:.: XP_016 ASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQ 170 180 190 200 210 220 XP_016 VVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICN 230 240 250 260 270 280 >>XP_016878350 (OMIM: 602703,616212) PREDICTED: katanin (672 aa) initn: 188 init1: 111 opt: 209 Z-score: 197.4 bits: 45.9 E(85289): 0.00029 Smith-Waterman score: 209; 27.4% identity (58.2% similar) in 146 aa overlap (180-323:77-218) 150 160 170 180 190 200 pF1KA1 SVCALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEE :..:: ..::. .::. :. . :. XP_016 LWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKA 50 60 70 80 90 100 210 220 230 240 250 260 pF1KA1 PVMDLDFDSQKARGISGSAGKALAVWSLDWQQ-ALQVRGTHELTNPGIAEVTIRPDRKIL . .::: ::: . .:.. . ... :: : . .. . . :: : : XP_016 NICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRG-H---SQAVRCLRFSPDGKWL 110 120 130 140 150 160 270 280 290 300 310 320 pF1KA1 ATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAF-TADGLLAAGSKDQRISLWSLYPRA :.:. :: .... . . .. . :.. :. : : . :::.::.:. : .:.: XP_016 ASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQ 170 180 190 200 210 220 XP_016 VVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICN 230 240 250 260 270 280 >>XP_016878349 (OMIM: 602703,616212) PREDICTED: katanin (675 aa) initn: 188 init1: 111 opt: 209 Z-score: 197.4 bits: 45.9 E(85289): 0.00029 Smith-Waterman score: 209; 27.4% identity (58.2% similar) in 146 aa overlap (180-323:77-218) 150 160 170 180 190 200 pF1KA1 SVCALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEE :..:: ..::. .::. :. . :. XP_016 LWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKA 50 60 70 80 90 100 210 220 230 240 250 260 pF1KA1 PVMDLDFDSQKARGISGSAGKALAVWSLDWQQ-ALQVRGTHELTNPGIAEVTIRPDRKIL . .::: ::: . .:.. . ... :: : . .. . . :: : : XP_016 NICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRG-H---SQAVRCLRFSPDGKWL 110 120 130 140 150 160 270 280 290 300 310 320 pF1KA1 ATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAF-TADGLLAAGSKDQRISLWSLYPRA :.:. :: .... . . .. . :.. :. : : . :::.::.:. : .:.: XP_016 ASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQ 170 180 190 200 210 220 XP_016 VVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICN 230 240 250 260 270 280 >>XP_006721184 (OMIM: 602703,616212) PREDICTED: katanin (675 aa) initn: 188 init1: 111 opt: 209 Z-score: 197.4 bits: 45.9 E(85289): 0.00029 Smith-Waterman score: 209; 27.4% identity (58.2% similar) in 146 aa overlap (180-323:77-218) 150 160 170 180 190 200 pF1KA1 SVCALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEE :..:: ..::. .::. :. . :. XP_006 LWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKA 50 60 70 80 90 100 210 220 230 240 250 260 pF1KA1 PVMDLDFDSQKARGISGSAGKALAVWSLDWQQ-ALQVRGTHELTNPGIAEVTIRPDRKIL . .::: ::: . .:.. . ... :: : . .. . . :: : : XP_006 NICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRG-H---SQAVRCLRFSPDGKWL 110 120 130 140 150 160 270 280 290 300 310 320 pF1KA1 ATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAF-TADGLLAAGSKDQRISLWSLYPRA :.:. :: .... . . .. . :.. :. : : . :::.::.:. : .:.: XP_006 ASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQ 170 180 190 200 210 220 XP_006 VVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICN 230 240 250 260 270 280 327 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 21:36:06 2016 done: Wed Nov 2 21:36:07 2016 Total Scan time: 5.730 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]