Result of FASTA (omim) for
pF1KA1693
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1693, 867 aa
1>>>pF1KA1693 867 - 867 aa - 867 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.8525+/-0.00047; mu= -0.4136+/- 0.029
mean_var=235.7789+/-49.205, 0's: 0 Z-trim(117.7): 111 B-trim: 1393 in 3/51
Lambda= 0.083526
statistics sampled from 29797 (29909) to 29797 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.661), E-opt: 0.2 (0.351), width: 16
Scan time: 13.500
The best scores are: opt bits E(85289)
NP_060410 (OMIM: 610501) neuroblastoma breakpoint (1214) 4586 566.6 2.5e-160
NP_001265070 (OMIM: 608607) neuroblastoma breakpoi (1457) 4495 555.7 5.7e-157
NP_001095133 (OMIM: 614001) neuroblastoma breakpoi ( 865) 4487 554.6 7.3e-157
NP_899228 (OMIM: 614001) neuroblastoma breakpoint ( 919) 4487 554.6 7.6e-157
NP_056198 (OMIM: 614003) neuroblastoma breakpoint (2819) 4480 554.0 3.4e-156
XP_011507697 (OMIM: 614003) PREDICTED: neuroblasto (2819) 4480 554.0 3.4e-156
NP_001034792 (OMIM: 614000) neuroblastoma breakpoi (3626) 4461 551.8 2.1e-155
NP_001289300 (OMIM: 614000) neuroblastoma breakpoi (3795) 4461 551.8 2.2e-155
NP_001032590 (OMIM: 613998) putative neuroblastoma ( 942) 4443 549.3 3.1e-155
NP_001032764 (OMIM: 613999) neuroblastoma breakpoi ( 942) 4422 546.8 1.8e-154
XP_006711380 (OMIM: 613999) PREDICTED: neuroblasto (1111) 4422 546.8 2e-154
NP_001264373 (OMIM: 613999) neuroblastoma breakpoi (1111) 4422 546.8 2e-154
XP_016856767 (OMIM: 613999) PREDICTED: neuroblasto ( 558) 3334 415.5 3.4e-115
NP_001164226 (OMIM: 610414,614005) neuroblastoma b ( 670) 2855 357.9 9.4e-98
NP_775909 (OMIM: 610414,614005) neuroblastoma brea ( 670) 2855 357.9 9.4e-98
XP_016856566 (OMIM: 610414,614005) PREDICTED: neur ( 670) 2855 357.9 9.4e-98
XP_016855356 (OMIM: 614006) PREDICTED: neuroblasto ( 671) 2833 355.2 5.9e-97
XP_016858508 (OMIM: 614006) PREDICTED: neuroblasto ( 671) 2833 355.2 5.9e-97
NP_115640 (OMIM: 612992) neuroblastoma breakpoint ( 633) 2654 333.6 1.7e-90
XP_011540580 (OMIM: 612992) PREDICTED: neuroblasto ( 577) 2575 324.1 1.2e-87
XP_006711022 (OMIM: 612992) PREDICTED: neuroblasto ( 577) 2575 324.1 1.2e-87
XP_011540579 (OMIM: 612992) PREDICTED: neuroblasto ( 577) 2575 324.1 1.2e-87
XP_011540578 (OMIM: 612992) PREDICTED: neuroblasto ( 577) 2575 324.1 1.2e-87
XP_016857988 (OMIM: 612992) PREDICTED: neuroblasto ( 577) 2575 324.1 1.2e-87
XP_006711021 (OMIM: 612992) PREDICTED: neuroblasto ( 577) 2575 324.1 1.2e-87
XP_011540583 (OMIM: 612992) PREDICTED: neuroblasto ( 577) 2575 324.1 1.2e-87
NP_001317310 (OMIM: 612992) neuroblastoma breakpoi ( 577) 2575 324.1 1.2e-87
NP_001243346 (OMIM: 612992) neuroblastoma breakpoi ( 563) 2283 288.9 4.6e-77
NP_001265196 (OMIM: 614007) neuroblastoma breakpoi (5207) 1891 242.2 4.7e-62
XP_006711020 (OMIM: 612992) PREDICTED: neuroblasto ( 596) 1669 214.9 8.9e-55
XP_011540314 (OMIM: 613996) PREDICTED: neuroblasto ( 656) 1632 210.5 2.1e-53
XP_011540316 (OMIM: 613996) PREDICTED: neuroblasto ( 656) 1632 210.5 2.1e-53
XP_016857637 (OMIM: 613996) PREDICTED: neuroblasto ( 656) 1632 210.5 2.1e-53
XP_005271201 (OMIM: 613996) PREDICTED: neuroblasto ( 715) 1632 210.5 2.3e-53
XP_016857990 (OMIM: 612992) PREDICTED: neuroblasto ( 540) 1590 205.4 6e-52
XP_016857991 (OMIM: 612992) PREDICTED: neuroblasto ( 540) 1590 205.4 6e-52
XP_016857989 (OMIM: 612992) PREDICTED: neuroblasto ( 540) 1590 205.4 6e-52
NP_001243345 (OMIM: 612992) neuroblastoma breakpoi ( 621) 1549 200.5 2.1e-50
NP_001041445 (OMIM: 613997) putative neuroblastoma ( 421) 1456 189.1 3.6e-47
XP_016856675 (OMIM: 613997) PREDICTED: putative ne ( 321) 1351 176.4 1.8e-43
XP_011539065 (OMIM: 613994) PREDICTED: neuroblasto ( 667) 1155 153.0 4.3e-36
NP_001137459 (OMIM: 613996) neuroblastoma breakpoi ( 667) 1155 153.0 4.3e-36
NP_001137460 (OMIM: 613996) neuroblastoma breakpoi ( 638) 1146 151.9 8.9e-36
NP_001137461 (OMIM: 613994) neuroblastoma breakpoi ( 638) 1146 151.9 8.9e-36
NP_001185761 (OMIM: 608117) myomegalin isoform 8 [ (2240) 276 47.4 0.0009
XP_016858392 (OMIM: 608117) PREDICTED: myomegalin (2243) 276 47.4 0.0009
XP_016858390 (OMIM: 608117) PREDICTED: myomegalin (2257) 276 47.4 0.00091
XP_016858389 (OMIM: 608117) PREDICTED: myomegalin (2273) 276 47.4 0.00091
XP_016858388 (OMIM: 608117) PREDICTED: myomegalin (2302) 276 47.4 0.00092
XP_011508481 (OMIM: 608117) PREDICTED: myomegalin (2345) 276 47.4 0.00094
>>NP_060410 (OMIM: 610501) neuroblastoma breakpoint fami (1214 aa)
initn: 8290 init1: 4582 opt: 4586 Z-score: 2999.5 bits: 566.6 E(85289): 2.5e-160
Smith-Waterman score: 5126; 88.8% identity (90.5% similar) in 899 aa overlap (1-823:272-1170)
10 20 30
pF1KA1 MVVSAGPLSSEKAEMNILEINEKLHPQLAE
:::::::::::::::::::.::::.:::::
NP_060 VDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAE
250 260 270 280 290 300
40 50 60 70 80 90
pF1KA1 KKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAE
:::::::::::::::::: ::::::::::::::.::::::::::::::::::::::::::
NP_060 KKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQAE
310 320 330 340 350 360
100 110 120 130 140 150
pF1KA1 ELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDKPDKSQGQDLQEQLAE
::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::
NP_060 ELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAE
370 380 390 400 410 420
160 170 180 190 200 210
pF1KA1 GCRLAQQLFQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAIT
::::::.: :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAIT
430 440 450 460 470 480
220 230 240 250 260 270
pF1KA1 CSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 CSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNV
490 500 510 520 530 540
280 290 300 310 320 330
pF1KA1 SMVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYK
::::::::::::::::::::.::::.::::::::::::::::::::::::::::::::::
NP_060 SMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYK
550 560 570 580 590 600
340 350 360 370 380 390
pF1KA1 YEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA
::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 YEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA
610 620 630 640 650 660
400 410 420 430 440 450
pF1KA1 SRSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLTQHLVQKLSPENDNDDDEDVQVEVA
:::::::::::::::.:::::::::::::::::::.:.: :::::::::: :::::::::
NP_060 SRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEVA
670 680 690 700 710 720
460 470 480 490 500 510
pF1KA1 EKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDST
730 740 750 760 770 780
520 530 540 550 560 570
pF1KA1 LTGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSI
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSI
790 800 810 820 830 840
580 590 600 610 620 630
pF1KA1 PPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGPE
::::::::::::.::::::::::::::::: :::::::::::::::::::::::::::::
NP_060 PPEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGPE
850 860 870 880 890 900
640
pF1KA1 VLQDSLDRCYSTPSGYLEL-----------------------------------------
:::::::::::::::::::
NP_060 VLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPS
910 920 930 940 950 960
650 660 670
pF1KA1 ----------------------------------PDLGQPYSSAVYSLEEQYLGLALDVD
::::::: ::::::::::::::::::
NP_060 CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD
970 980 990 1000 1010 1020
680 690 700 710 720 730
pF1KA1 RIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSF
:::::::::::::::::::::::::.::::::::::::::::::::::::::: ::::::
NP_060 RIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSF
1030 1040 1050 1060 1070 1080
740 750 760 770 780 790
pF1KA1 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLNGVLME
::::::::::::::::::::::::::::::: ::.:::::::::::::::::::.:.:::
NP_060 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLME
1090 1100 1110 1120 1130 1140
800 810 820 830 840 850
pF1KA1 VEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLTVTS
:::::::::::: ::::::::::::::::
NP_060 VEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVDNRFLTLMGTS
1150 1160 1170 1180 1190 1200
>--
initn: 1677 init1: 1677 opt: 1677 Z-score: 1105.0 bits: 216.1 E(85289): 8.2e-55
Smith-Waterman score: 1677; 95.6% identity (98.2% similar) in 271 aa overlap (1-271:1-271)
10 20 30 40 50 60
pF1KA1 MVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKY
::::::: :::::: :::::::::.:::::.::::::::::::::::: ::::.:.::::
NP_060 MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 RSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDEDEDEDVQVEEAE
::::::::::::::.:::::::::::::::::::::.: :::::::::::::::::::::
NP_060 RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
NP_060 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLA
:::::::::::::::::::::::::::::::
NP_060 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQA
NP_060 EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQA
310 320 330 340 350 360
>>NP_001265070 (OMIM: 608607) neuroblastoma breakpoint f (1457 aa)
initn: 8981 init1: 4491 opt: 4495 Z-score: 2939.1 bits: 555.7 E(85289): 5.7e-157
Smith-Waterman score: 4966; 86.5% identity (89.4% similar) in 898 aa overlap (1-823:272-1169)
10 20 30
pF1KA1 MVVSAGPLSSEKAEMNILEINEKLHPQLAE
::::::::::::::::::::::::.:::::
NP_001 VDRKSSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLAE
250 260 270 280 290 300
40 50 60 70 80 90
pF1KA1 KKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAE
::::::.::::::::::: :::.::::::::::::::::::::: :::::::::::::::
NP_001 KKQQFRSLKEKCFVTQLAGFLAKQQNKYKYEECKDLIKSMLRNELQFKEEKLAEQLKQAE
310 320 330 340 350 360
100 110 120 130 140 150
pF1KA1 ELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDKPDKSQGQDLQEQLAE
::::::::::::::::::::::::::::::::::.:::::::::.:::::::::::::::
NP_001 ELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAE
370 380 390 400 410 420
160 170 180 190 200 210
pF1KA1 GCRLAQQLFQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAIT
::::::.: ::::::::::::::::::: :::::::.:::.:::::::::::::::::::
NP_001 GCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSSPREMQKAEESKVPEDSLEECAIT
430 440 450 460 470 480
220 230 240 250 260 270
pF1KA1 CSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNV
:::::::::::::::::.::::::::::.:::::::::::::::.:::::::::::::::
NP_001 CSNSHGPCDSNQPHKNIKITFEEDKVNSSLVVDRESSHDECQDALNILPVPGPTSSATNV
490 500 510 520 530 540
280 290 300 310 320 330
pF1KA1 SMVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYK
:::::::::::::::::::::::::.:::::::::::.:::::::::.:::::.::::::
NP_001 SMVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYK
550 560 570 580 590 600
340 350 360 370 380 390
pF1KA1 YEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA
:::::::.::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_001 YEECKDLLKSMLRNELQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA
610 620 630 640 650 660
400 410 420 430 440 450
pF1KA1 SRSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLTQHLVQKLSPENDNDDDEDVQVEVA
:::::.:::::::::.:::::::::::::::::::.::::::::::::::::::::::::
NP_001 SRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVA
670 680 690 700 710 720
460 470 480 490 500 510
pF1KA1 EKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDST
:::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDST
730 740 750 760 770 780
520 530 540 550 560 570
pF1KA1 LTGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSI
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSI
790 800 810 820 830 840
580 590 600 610 620
pF1KA1 PPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEK---
::: :::::::::::::::::::::::::::::::::::::::::::::::::: ::
NP_001 PPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLAEKEPE
850 860 870 880 890 900
pF1KA1 -----------------G------------------------------------------
:
NP_001 VLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPS
910 920 930 940 950 960
630 640 650 660 670
pF1KA1 -------------PEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD
:::::::::::::::::::::::::::: ::::::::::::::::::
NP_001 CPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD
970 980 990 1000 1010 1020
680 690 700 710 720 730
pF1KA1 RIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSF
:::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
NP_001 RIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYRSSF
1030 1040 1050 1060 1070 1080
740 750 760 770 780 790
pF1KA1 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNGVLMEV
:::::::::::::::::::::::::::::::::.:::::::::::::::::::. :.
NP_001 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEEDQNPPCPRLSRELLAE
1090 1100 1110 1120 1130 1140
800 810 820 830 840 850
pF1KA1 EEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLTVTSL
.:::::::::: :::::.:. : : :
NP_001 KEPEVLQDSLDRWYSTPSVYLGLTDPCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEED
1150 1160 1170 1180 1190 1200
>--
initn: 1694 init1: 1694 opt: 1694 Z-score: 1114.9 bits: 218.1 E(85289): 2.3e-55
Smith-Waterman score: 1694; 88.2% identity (93.4% similar) in 287 aa overlap (581-867:1171-1457)
560 570 580 590 600 610
pF1KA1 SEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKE
: :.:. ::.:.: .:::. . . : .:
NP_001 EKEPEVLQDSLDRWYSTPSVYLGLTDPCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEE
1150 1160 1170 1180 1190 1200
620 630 640 650 660 670
pF1KA1 DQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGL
::. . :::::::: :: :::::::::::::::::::::::::::: :::::::::::::
NP_001 DQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGL
1210 1220 1230 1240 1250 1260
680 690 700 710 720 730
pF1KA1 ALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQP
1270 1280 1290 1300 1310 1320
740 750 760 770 780 790
pF1KA1 YGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNG
: ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::.
NP_001 YRSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEEDQNPPCPRLNS
1330 1340 1350 1360 1370 1380
800 810 820 830 840 850
pF1KA1 VLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTL
:::::::::::::::: ::::::::::::::::::::::::::::::.::: .:: ::::
NP_001 VLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHITFALDMDNSFFTL
1390 1400 1410 1420 1430 1440
860
pF1KA1 TVTSLHLVFQMEVIFPQ
::::::::::: :::::
NP_001 TVTSLHLVFQMGVIFPQ
1450
>--
initn: 1642 init1: 1642 opt: 1642 Z-score: 1081.1 bits: 211.9 E(85289): 1.8e-53
Smith-Waterman score: 1642; 93.0% identity (97.8% similar) in 271 aa overlap (1-271:1-271)
10 20 30 40 50 60
pF1KA1 MVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKY
::::::: ::::::::::::::::.:::::.:::::::::.::.:::: ::::.:.::::
NP_001 MVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFRNLKERCFLTQLAGFLANRQKKYKY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 RSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDEDEDEDVQVEEAE
::::.:::::::::.::::::::::::::::::::::: ::::::::::::::::::: :
NP_001 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLVQKLSPENDEDEDEDVQVEEDE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSAL
:::::::::::::::::::::::::::::::::::::::: ::::::.::::::::::..
NP_001 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLA
::::.:::::::::.::::::::::::::::
NP_001 VVDRKSSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQA
NP_001 EKKQQFRSLKEKCFVTQLAGFLAKQQNKYKYEECKDLIKSMLRNELQFKEEKLAEQLKQA
310 320 330 340 350 360
>>NP_001095133 (OMIM: 614001) neuroblastoma breakpoint f (865 aa)
initn: 6034 init1: 4483 opt: 4487 Z-score: 2937.2 bits: 554.6 E(85289): 7.3e-157
Smith-Waterman score: 4607; 85.6% identity (90.9% similar) in 838 aa overlap (1-832:1-819)
10 20 30 40 50 60
pF1KA1 MVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKY
::::::: ::::::::::::::::.:::::.:::::::::.::.:::: ::::.:.::::
NP_001 MVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFRNLKERCFLTQLAGFLANRQKKYKY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 RSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDEDEDEDVQVEEAE
::::.:::::::::.:::::::::::::::::::::.: ::::::::::::::::::: :
NP_001 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSAL
:::::::::::::::::::::::::::::::::::::::: ::::::.::::::::::.:
NP_001 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLA
::::::::: ::::.:::::::::::::::::::::::::::::::::::::::: ::::
NP_001 VVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQA
:::::::.:::::::::.:::::.::::::::::::::::::::::::::::::::::::
NP_001 EKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDKPDKSQGQDLQEQLA
:::::::::::::::::::::::::::::::::::.:::::::::.::::::::::::::
NP_001 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 EGCRLTQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI
:::::.:::::::::::::::::::::::::::::::.::::::::::::::::::::::
NP_001 EGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 TCSNSHGPYDSNQPHRKTKITFEEDKVDSTLTGSSSHVEWEDAVHIIPENESDDEEEEEK
::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
NP_001 TCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIG
::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
NP_001 GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 RHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAV
::::::::::::::::::::::::::: :::::::::::::::: :: : : ::: ::
NP_001 RHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAF
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 YSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSS
: ::.: .:::.:.:.:.: :: :::: : ::::::::: :::::::::::::::::.
NP_001 YVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 CLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEED
:: :: ::: :. :.:::...:..::: .:.: .: :::
NP_001 YLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKD-------------------QEEEED
730 740 750 760
790 800 810 820 830
pF1KA1 QNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFEL-PDS-----FQHYRSVFYSFEE
:.::::::. :.:: :::::::::: : . : : : :.:.:. . .:
NP_001 QGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPVVLNSLTPASPTEVPFMHWRKNMLAFLL
770 780 790 800 810 820
840 850 860
pF1KA1 QHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
NP_001 TWEKLKRRGRGRKEGEEDQRRKEEGEEKKGKKIKTHHAPGSAAC
830 840 850 860
>>NP_899228 (OMIM: 614001) neuroblastoma breakpoint fami (919 aa)
initn: 6053 init1: 4483 opt: 4487 Z-score: 2936.8 bits: 554.6 E(85289): 7.6e-157
Smith-Waterman score: 4607; 85.6% identity (90.9% similar) in 838 aa overlap (1-832:55-873)
10 20 30
pF1KA1 MVVSAGPLSSEKAEMNILEINEKLHPQLAE
::::::: ::::::::::::::::.:::::
NP_899 VNAKKQLPVGIKCEPMDQVPDSTSSATNVSMVVSAGPWSSEKAEMNILEINEKLRPQLAE
30 40 50 60 70 80
40 50 60 70 80 90
pF1KA1 KKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAE
.:::::::::.::.:::: ::::.:.:::::::::::: :::::::::::::::::::::
NP_899 NKQQFRNLKERCFLTQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAE
90 100 110 120 130 140
100 110 120 130 140 150
pF1KA1 ELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDKPDKSQGQDLQEQLAE
::::::::::::::::::::::::::::::::::.:::::::::.:::::::::::::::
NP_899 ELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAE
150 160 170 180 190 200
160 170 180 190 200 210
pF1KA1 GCRLAQQLFQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAIT
::::::.: ::::::::::::::::::: :::::::::::::::::::::::::::::::
NP_899 GCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAIT
210 220 230 240 250 260
220 230 240 250 260 270
pF1KA1 CSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNV
:::::::::: ::::::.::::::::::.:::::::::: ::::.:::::::::::::::
NP_899 CSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNV
270 280 290 300 310 320
280 290 300 310 320 330
pF1KA1 SMVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYK
::::::::::::::::::::::::: :::::::::::.:::::::::.:::::.::::::
NP_899 SMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYK
330 340 350 360 370 380
340 350 360 370 380 390
pF1KA1 YEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 YEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA
390 400 410 420 430 440
400 410 420 430 440 450
pF1KA1 SRSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLTQHLVQKLSPENDNDDDEDVQVEVA
:::::.:::::::::.:::::::::::::::::::.::::::::::::::::::::::::
NP_899 SRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVA
450 460 470 480 490 500
460 470 480 490 500 510
pF1KA1 EKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDST
:::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 EKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDST
510 520 530 540 550 560
520 530 540 550 560 570
pF1KA1 LTGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSI
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 LIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSI
570 580 590 600 610 620
580 590 600 610 620 630
pF1KA1 PPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGPE
::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
NP_899 PPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPE
630 640 650 660 670 680
640 650 660 670 680 690
pF1KA1 VLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPP
:::::::::::::: :: : : ::: :: : ::.: .:::.:.:.:.: :: :::: :
NP_899 VLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPS
690 700 710 720 730 740
700 710 720 730 740 750
pF1KA1 CPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVG
::::::::: :::::::::::::::::. :: :: ::: :. :.:::...:..:::
NP_899 CPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD
750 760 770 780 790 800
760 770 780 790 800 810
pF1KA1 EIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYS
.:.: .: ::::.::::::. :.:: ::::::::::
NP_899 RIKKD-------------------QEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQL
810 820 830 840
820 830 840 850 860
pF1KA1 TPSMYFEL-PDS-----FQHYRSVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVI
: . : : : :.:.:. . .:
NP_899 LPVVLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRGRGRKEGEEDQRRKEEGEEKKG
850 860 870 880 890 900
>>NP_056198 (OMIM: 614003) neuroblastoma breakpoint fami (2819 aa)
initn: 17546 init1: 4480 opt: 4480 Z-score: 2925.1 bits: 554.0 E(85289): 3.4e-156
Smith-Waterman score: 4958; 86.5% identity (89.2% similar) in 898 aa overlap (1-823:1-898)
10 20 30 40 50 60
pF1KA1 MVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKY
::::::: :::::::::::::: :.::::::::::::::::::.:::: ::::::.::::
NP_056 MVVSAGPWSSEKAEMNILEINETLRPQLAEKKQQFRNLKEKCFLTQLAGFLANQQKKYKY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 RSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDEDEDEDVQVEEAE
::: .:::::::: .:::::::::::::::::::::.: :::::::::::::::::::::
NP_056 RSLYEHLQALLTPYEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSAL
:::::::::::::::::::::::::::::::::::::::::::::::.::::::.:::.:
NP_056 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLA
::::::::::::::.::::::::::::::::::::::::::::::::::::::::.::::
NP_056 VVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQA
::::::::::::::.:::. ::::::.:::::::::::: ::::::::::::::::::::
NP_056 EKKQQFRNLKEKCFLTQLSGFLANQQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDKPDKSQGQDLQEQLA
:::::::::::.:::::::::::::::::::::::.:::::::::.::::::::::::::
NP_056 EELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 EGCRLTQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 TCSNSHGPYDSNQPHRKTKITFEEDKVDSTLTGSSSHVEWEDAVHIIPENESDDEEEEEK
: ::::: ::::::::::::::::::::::: ::::::::::::::::::::::::::::
NP_056 TYSNSHGSYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIG
550 560 570 580 590 600
610 620 630 640
pF1KA1 RHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSG---------------
:::::::::::::::::::::::::::::::::::::::::::::
NP_056 RHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAF
610 620 630 640 650 660
pF1KA1 ------------------------------------------------------------
NP_056 YVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSG
670 680 690 700 710 720
650 660 670 680 690 700
pF1KA1 YLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPE
:::::::::::::::::::::::::::::::::::.:::::: :::::::::::::::::
NP_056 YLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDEEEEEDQDPPCPRLSRELLEVVEPE
730 740 750 760 770 780
710 720 730 740 750 760
pF1KA1 VLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR
790 800 810 820 830 840
770 780 790 800 810 820
pF1KA1 SKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHY
:::::::::::::::::::::::. :.. . ::::::::: :::::: .:: :: :
NP_056 SKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPY
850 860 870 880 890 900
830 840 850 860
pF1KA1 RSVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
NP_056 RSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYS
910 920 930 940 950 960
>--
initn: 10170 init1: 1480 opt: 1575 Z-score: 1033.2 bits: 204.0 E(85289): 8.2e-51
Smith-Waterman score: 1619; 43.2% identity (65.2% similar) in 768 aa overlap (147-844:1868-2627)
120 130 140 150 160 170
pF1KA1 RDASRSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLFQKLSPEN---DEDEDED
.:...:. .. : : . : ::
NP_056 RLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEI
1840 1850 1860 1870 1880 1890
180 190 200 210 220 230
pF1KA1 VQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINIT
. .:.:. . : :: :. .: .: .:::..: : :. : .::... .
NP_056 EKYKEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYS
1900 1910 1920 1930 1940 1950
240 250 260 270 280
pF1KA1 FEEDKVNSALVVDR-ESSHDECQDAVNILPVPGPTSSATNV--SMVVSAGPLSSEKAEMN
.::. .. :: ::: .....: .: : : . .: :.. . .. .
NP_056 LEEQYLGLALDVDRIKKDQEEEEDQGP--PCPRLSRELLEVVEPEVLQDSLDRCYSTPSS
1960 1970 1980 1990 2000 2010
290 300 310 320 330 340
pF1KA1 ILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQ
:: .. .: ..: :.:: .: ....: : .. . : :....
NP_056 CLEQPDSCQPY----GSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKE
2020 2030 2040 2050 2060 2070
350 360 370 380 390
pF1KA1 FKEEKLAEQLKQAEELRQYK---VLVHSQERELT------QLREKLREGRDASRSLNQHL
.:.. . ..:: . : :: : .: . .: .. . :.: :.:.
NP_056 GEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQ-
2080 2090 2100 2110 2120 2130
400 410 420 430 440
pF1KA1 QALLTPDKPDKSQGQDLQEQLAEGC-RLTQHLVQKLSPE--NDNDD--------------
.. :. : . . ....:. .: ::...:... :: .:. :
NP_056 RVGLAVDMDEIEKYKEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPD
2140 2150 2160 2170 2180 2190
450 460 470
pF1KA1 ------------DE-------DV-QVEVAEKVQKSSAP------REMQKAEEKEVPEDSL
.: :: ... .. .....: ::. .. : :: .:::
NP_056 LGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSL
2200 2210 2220 2230 2240 2250
480 490 500 510 520 530
pF1KA1 EECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL-TG---SSSHVEWEDAVHIIPENE
..: : :. :: ::. .. ..:: .: .: .: .... . . . . : .
NP_056 DRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERR
2260 2270 2280 2290 2300 2310
540 550 560 570 580
pF1KA1 SDDEE-EEEKGPVSPRNLQESEEEEVP---QESWDEGYSTLSIPPEMLASYQSYSSTFHS
.: ::...: :: .: .:. : :.: :. ::: : :. : : : :.:.
NP_056 RGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYV
2320 2330 2340 2350 2360 2370
590 600 610 620 630 640
pF1KA1 LEEQQVCMAVDIGR-HRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGY
::.:.: .:::. . ... .:. :::. . ::::::::::: ::::::::::::::::::
NP_056 LEQQRVGLAVDMDEIEKYKEVE-EDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGY
2380 2390 2400 2410 2420
650 660 670 680 690 700
pF1KA1 LELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV
2430 2440 2450 2460 2470 2480
710 720 730 740 750 760
pF1KA1 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS
2490 2500 2510 2520 2530 2540
770 780 790 800 810 820
pF1KA1 KKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYR
::::::::::::::::::::::. :.. . ::::::::: :::::: .:: :: : ::
NP_056 KKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYR
2550 2560 2570 2580 2590 2600
830 840 850 860
pF1KA1 SVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
:.:: .:.:....:. .:
NP_056 SAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKDPEVLQDSLDRCYST
2610 2620 2630 2640 2650 2660
>--
initn: 4306 init1: 1468 opt: 1560 Z-score: 1023.4 bits: 202.2 E(85289): 2.9e-50
Smith-Waterman score: 1560; 54.9% identity (72.9% similar) in 501 aa overlap (361-844:919-1407)
340 350 360 370 380
pF1KA1 YEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQE-------RELTQLREK
.:...:. . ..:. ::: . .:
NP_056 GCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEP
890 900 910 920 930 940
390 400 410 420 430 440
pF1KA1 LREGRDASRSLNQHLQALLTPD--KPDKSQGQDLQEQLAEGCRLTQHLVQKLSPENDNDD
. .: . : :: .: .: .:.:: : : :.... ......
NP_056 EVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYL-GLALD---VDRIKKDEEEEE
950 960 970 980 990 1000
450 460 470 480 490 500
pF1KA1 DEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKIT
:.: . : ::. .. : :: .:::..: : :. :: ::. .. .
NP_056 DQD------PPCPRLS--RELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYA
1010 1020 1030 1040 1050
510 520 530 540 550
pF1KA1 FEEDKVDSTL-TG---SSSHVEWEDAVHIIPENESDDEE-EEEKGPVSPRNLQESEEEEV
.:: .: .: .: .... . . . . : . .: ::...: :: .: .:.
NP_056 LEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKG
1060 1070 1080 1090 1100 1110
560 570 580 590 600 610
pF1KA1 P---QESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQE
: :.: :. ::: : :. : : : :.:. ::.:.: .:::. . . : .:::.
NP_056 PEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQD
1120 1130 1140 1150 1160 1170
620 630 640 650 660 670
pF1KA1 ATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD
. ::::::::::: :::::::::::::::::::::::::::::::::::::::::::::
NP_056 PSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD
1180 1190 1200 1210 1220 1230
680 690 700 710 720 730
pF1KA1 VDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGS
:::::::.:::::: :::::::::::::::::::::::::::::::::::::::::::::
NP_056 VDRIKKDEEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGS
1240 1250 1260 1270 1280 1290
740 750 760 770 780 790
pF1KA1 SFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNGVLM
:::::::::::::::::::::::::::::::::::::::::::::::::::::::. :.
NP_056 SFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELL
1300 1310 1320 1330 1340 1350
800 810 820 830 840 850
pF1KA1 EVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLTVT
. . ::::::::: :::::: .:: :: : :::.:: .:.:....:. .:
NP_056 HEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAVDMDEIEKYKEVE
1360 1370 1380 1390 1400 1410
860
pF1KA1 SLHLVFQMEVIFPQ
NP_056 EDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLG
1420 1430 1440 1450 1460 1470
>--
initn: 2243 init1: 1400 opt: 1486 Z-score: 975.2 bits: 193.3 E(85289): 1.4e-47
Smith-Waterman score: 1486; 56.4% identity (73.5% similar) in 472 aa overlap (362-813:1408-1864)
340 350 360 370 380
pF1KA1 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQE-------RELTQLREK-
:...:: . ..:. ::: . .:
NP_056 CLELTDSCQPYRSAFYILEQQRVGLAVDMDEIEKYKEVEEDQDPSCPRLSRELLDEKEPE
1380 1390 1400 1410 1420 1430
390 400 410 420 430 440
pF1KA1 -LREGRDASRSLNQHLQALLTPD--KPDKSQGQDLQEQLAEGCRLTQHLVQKLSPENDND
:... : : . : :: .: .: .:.:: : : :.... .....
NP_056 VLQDSLD--RCYSTPSGYLELPDLGQPYSSAVYSLEEQYL-GLALD---VDRFKKDEEEE
1440 1450 1460 1470 1480 1490
450 460 470 480 490 500
pF1KA1 DDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKI
.:.: . : ::. .. : :: .:::..: : :. :: ::. ..
NP_056 EDQD------PPCPRLS--RELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFY
1500 1510 1520 1530 1540
510 520 530 540 550
pF1KA1 TFEEDKVDSTL-TG---SSSHVEWEDAVHIIPENESDDEE-EEEKGPVSPRNLQESEEEE
..:: .: .: .: .... . . . . : . .: ::...: :: .: .:.
NP_056 ALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEK
1550 1560 1570 1580 1590 1600
560 570 580 590 600 610
pF1KA1 VP---QESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGR-HRWDQVKKED
: :.: :. ::: : :. : : : :.:. ::.:.: .:::. . ... .:. ::
NP_056 GPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYKEVE-ED
1610 1620 1630 1640 1650 1660
620 630 640 650 660 670
pF1KA1 QEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLA
:. . ::::::::::: :::::::::::::::::::::::::::::::::::::::::::
NP_056 QDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLA
1670 1680 1690 1700 1710 1720
680 690 700 710 720 730
pF1KA1 LDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPY
1730 1740 1750 1760 1770 1780
740 750 760 770 780 790
pF1KA1 GSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNGV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
NP_056 GSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRE
1790 1800 1810 1820 1830 1840
800 810 820 830 840 850
pF1KA1 LMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLT
:.. . ::::::::: ::::::
NP_056 LLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYKE
1850 1860 1870 1880 1890 1900
>--
initn: 1092 init1: 1092 opt: 1092 Z-score: 718.6 bits: 145.8 E(85289): 2.7e-33
Smith-Waterman score: 1092; 85.3% identity (92.1% similar) in 191 aa overlap (677-867:2629-2819)
650 660 670 680 690 700
pF1KA1 LELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV
:.: :: :::: : :::::::::. .:::
NP_056 LELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKDPEV
2600 2610 2620 2630 2640 2650
710 720 730 740 750 760
pF1KA1 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS
:::::::::::::. :: :: :::.:. :.:::...:..::: .:::::::::::::::
NP_056 LQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDKIEKKGKGKKRRGRRS
2660 2670 2680 2690 2700 2710
770 780 790 800 810 820
pF1KA1 KKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYR
::::::::::::::::::::::::::::::: :::::::: :::::::::::::::::::
NP_056 KKERRRGRKEGEEDQNPPCPRLNGVLMEVEEREVLQDSLDRCYSTPSMYFELPDSFQHYR
2720 2730 2740 2750 2760 2770
830 840 850 860
pF1KA1 SVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
::::::::::::::::::::::::::::::::::: :::::
NP_056 SVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMGVIFPQ
2780 2790 2800 2810
>>XP_011507697 (OMIM: 614003) PREDICTED: neuroblastoma b (2819 aa)
initn: 17546 init1: 4480 opt: 4480 Z-score: 2925.1 bits: 554.0 E(85289): 3.4e-156
Smith-Waterman score: 4958; 86.5% identity (89.2% similar) in 898 aa overlap (1-823:1-898)
10 20 30 40 50 60
pF1KA1 MVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKY
::::::: :::::::::::::: :.::::::::::::::::::.:::: ::::::.::::
XP_011 MVVSAGPWSSEKAEMNILEINETLRPQLAEKKQQFRNLKEKCFLTQLAGFLANQQKKYKY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 RSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDEDEDEDVQVEEAE
::: .:::::::: .:::::::::::::::::::::.: :::::::::::::::::::::
XP_011 RSLYEHLQALLTPYEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSAL
:::::::::::::::::::::::::::::::::::::::::::::::.::::::.:::.:
XP_011 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLA
::::::::::::::.::::::::::::::::::::::::::::::::::::::::.::::
XP_011 VVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQA
::::::::::::::.:::. ::::::.:::::::::::: ::::::::::::::::::::
XP_011 EKKQQFRNLKEKCFLTQLSGFLANQQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDKPDKSQGQDLQEQLA
:::::::::::.:::::::::::::::::::::::.:::::::::.::::::::::::::
XP_011 EELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 EGCRLTQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 TCSNSHGPYDSNQPHRKTKITFEEDKVDSTLTGSSSHVEWEDAVHIIPENESDDEEEEEK
: ::::: ::::::::::::::::::::::: ::::::::::::::::::::::::::::
XP_011 TYSNSHGSYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIG
550 560 570 580 590 600
610 620 630 640
pF1KA1 RHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSG---------------
:::::::::::::::::::::::::::::::::::::::::::::
XP_011 RHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAF
610 620 630 640 650 660
pF1KA1 ------------------------------------------------------------
XP_011 YVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSG
670 680 690 700 710 720
650 660 670 680 690 700
pF1KA1 YLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPE
:::::::::::::::::::::::::::::::::::.:::::: :::::::::::::::::
XP_011 YLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDEEEEEDQDPPCPRLSRELLEVVEPE
730 740 750 760 770 780
710 720 730 740 750 760
pF1KA1 VLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR
790 800 810 820 830 840
770 780 790 800 810 820
pF1KA1 SKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHY
:::::::::::::::::::::::. :.. . ::::::::: :::::: .:: :: :
XP_011 SKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPY
850 860 870 880 890 900
830 840 850 860
pF1KA1 RSVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
XP_011 RSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYS
910 920 930 940 950 960
>--
initn: 10170 init1: 1480 opt: 1575 Z-score: 1033.2 bits: 204.0 E(85289): 8.2e-51
Smith-Waterman score: 1619; 43.2% identity (65.2% similar) in 768 aa overlap (147-844:1868-2627)
120 130 140 150 160 170
pF1KA1 RDASRSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLFQKLSPEN---DEDEDED
.:...:. .. : : . : ::
XP_011 RLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEI
1840 1850 1860 1870 1880 1890
180 190 200 210 220 230
pF1KA1 VQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINIT
. .:.:. . : :: :. .: .: .:::..: : :. : .::... .
XP_011 EKYKEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYS
1900 1910 1920 1930 1940 1950
240 250 260 270 280
pF1KA1 FEEDKVNSALVVDR-ESSHDECQDAVNILPVPGPTSSATNV--SMVVSAGPLSSEKAEMN
.::. .. :: ::: .....: .: : : . .: :.. . .. .
XP_011 LEEQYLGLALDVDRIKKDQEEEEDQGP--PCPRLSRELLEVVEPEVLQDSLDRCYSTPSS
1960 1970 1980 1990 2000 2010
290 300 310 320 330 340
pF1KA1 ILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQ
:: .. .: ..: :.:: .: ....: : .. . : :....
XP_011 CLEQPDSCQPY----GSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKE
2020 2030 2040 2050 2060 2070
350 360 370 380 390
pF1KA1 FKEEKLAEQLKQAEELRQYK---VLVHSQERELT------QLREKLREGRDASRSLNQHL
.:.. . ..:: . : :: : .: . .: .. . :.: :.:.
XP_011 GEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQ-
2080 2090 2100 2110 2120 2130
400 410 420 430 440
pF1KA1 QALLTPDKPDKSQGQDLQEQLAEGC-RLTQHLVQKLSPE--NDNDD--------------
.. :. : . . ....:. .: ::...:... :: .:. :
XP_011 RVGLAVDMDEIEKYKEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPD
2140 2150 2160 2170 2180 2190
450 460 470
pF1KA1 ------------DE-------DV-QVEVAEKVQKSSAP------REMQKAEEKEVPEDSL
.: :: ... .. .....: ::. .. : :: .:::
XP_011 LGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSL
2200 2210 2220 2230 2240 2250
480 490 500 510 520 530
pF1KA1 EECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL-TG---SSSHVEWEDAVHIIPENE
..: : :. :: ::. .. ..:: .: .: .: .... . . . . : .
XP_011 DRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERR
2260 2270 2280 2290 2300 2310
540 550 560 570 580
pF1KA1 SDDEE-EEEKGPVSPRNLQESEEEEVP---QESWDEGYSTLSIPPEMLASYQSYSSTFHS
.: ::...: :: .: .:. : :.: :. ::: : :. : : : :.:.
XP_011 RGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYV
2320 2330 2340 2350 2360 2370
590 600 610 620 630 640
pF1KA1 LEEQQVCMAVDIGR-HRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGY
::.:.: .:::. . ... .:. :::. . ::::::::::: ::::::::::::::::::
XP_011 LEQQRVGLAVDMDEIEKYKEVE-EDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGY
2380 2390 2400 2410 2420
650 660 670 680 690 700
pF1KA1 LELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV
2430 2440 2450 2460 2470 2480
710 720 730 740 750 760
pF1KA1 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS
2490 2500 2510 2520 2530 2540
770 780 790 800 810 820
pF1KA1 KKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYR
::::::::::::::::::::::. :.. . ::::::::: :::::: .:: :: : ::
XP_011 KKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYR
2550 2560 2570 2580 2590 2600
830 840 850 860
pF1KA1 SVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
:.:: .:.:....:. .:
XP_011 SAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKDPEVLQDSLDRCYST
2610 2620 2630 2640 2650 2660
>--
initn: 4306 init1: 1468 opt: 1560 Z-score: 1023.4 bits: 202.2 E(85289): 2.9e-50
Smith-Waterman score: 1560; 54.9% identity (72.9% similar) in 501 aa overlap (361-844:919-1407)
340 350 360 370 380
pF1KA1 YEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQE-------RELTQLREK
.:...:. . ..:. ::: . .:
XP_011 GCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEP
890 900 910 920 930 940
390 400 410 420 430 440
pF1KA1 LREGRDASRSLNQHLQALLTPD--KPDKSQGQDLQEQLAEGCRLTQHLVQKLSPENDNDD
. .: . : :: .: .: .:.:: : : :.... ......
XP_011 EVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYL-GLALD---VDRIKKDEEEEE
950 960 970 980 990 1000
450 460 470 480 490 500
pF1KA1 DEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKIT
:.: . : ::. .. : :: .:::..: : :. :: ::. .. .
XP_011 DQD------PPCPRLS--RELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYA
1010 1020 1030 1040 1050
510 520 530 540 550
pF1KA1 FEEDKVDSTL-TG---SSSHVEWEDAVHIIPENESDDEE-EEEKGPVSPRNLQESEEEEV
.:: .: .: .: .... . . . . : . .: ::...: :: .: .:.
XP_011 LEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKG
1060 1070 1080 1090 1100 1110
560 570 580 590 600 610
pF1KA1 P---QESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQE
: :.: :. ::: : :. : : : :.:. ::.:.: .:::. . . : .:::.
XP_011 PEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQD
1120 1130 1140 1150 1160 1170
620 630 640 650 660 670
pF1KA1 ATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD
. ::::::::::: :::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD
1180 1190 1200 1210 1220 1230
680 690 700 710 720 730
pF1KA1 VDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGS
:::::::.:::::: :::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDRIKKDEEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGS
1240 1250 1260 1270 1280 1290
740 750 760 770 780 790
pF1KA1 SFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNGVLM
:::::::::::::::::::::::::::::::::::::::::::::::::::::::. :.
XP_011 SFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELL
1300 1310 1320 1330 1340 1350
800 810 820 830 840 850
pF1KA1 EVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLTVT
. . ::::::::: :::::: .:: :: : :::.:: .:.:....:. .:
XP_011 HEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAVDMDEIEKYKEVE
1360 1370 1380 1390 1400 1410
860
pF1KA1 SLHLVFQMEVIFPQ
XP_011 EDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLG
1420 1430 1440 1450 1460 1470
>--
initn: 2243 init1: 1400 opt: 1486 Z-score: 975.2 bits: 193.3 E(85289): 1.4e-47
Smith-Waterman score: 1486; 56.4% identity (73.5% similar) in 472 aa overlap (362-813:1408-1864)
340 350 360 370 380
pF1KA1 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQE-------RELTQLREK-
:...:: . ..:. ::: . .:
XP_011 CLELTDSCQPYRSAFYILEQQRVGLAVDMDEIEKYKEVEEDQDPSCPRLSRELLDEKEPE
1380 1390 1400 1410 1420 1430
390 400 410 420 430 440
pF1KA1 -LREGRDASRSLNQHLQALLTPD--KPDKSQGQDLQEQLAEGCRLTQHLVQKLSPENDND
:... : : . : :: .: .: .:.:: : : :.... .....
XP_011 VLQDSLD--RCYSTPSGYLELPDLGQPYSSAVYSLEEQYL-GLALD---VDRFKKDEEEE
1440 1450 1460 1470 1480 1490
450 460 470 480 490 500
pF1KA1 DDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKI
.:.: . : ::. .. : :: .:::..: : :. :: ::. ..
XP_011 EDQD------PPCPRLS--RELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFY
1500 1510 1520 1530 1540
510 520 530 540 550
pF1KA1 TFEEDKVDSTL-TG---SSSHVEWEDAVHIIPENESDDEE-EEEKGPVSPRNLQESEEEE
..:: .: .: .: .... . . . . : . .: ::...: :: .: .:.
XP_011 ALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEK
1550 1560 1570 1580 1590 1600
560 570 580 590 600 610
pF1KA1 VP---QESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGR-HRWDQVKKED
: :.: :. ::: : :. : : : :.:. ::.:.: .:::. . ... .:. ::
XP_011 GPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYKEVE-ED
1610 1620 1630 1640 1650 1660
620 630 640 650 660 670
pF1KA1 QEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLA
:. . ::::::::::: :::::::::::::::::::::::::::::::::::::::::::
XP_011 QDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLA
1670 1680 1690 1700 1710 1720
680 690 700 710 720 730
pF1KA1 LDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPY
1730 1740 1750 1760 1770 1780
740 750 760 770 780 790
pF1KA1 GSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNGV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_011 GSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRE
1790 1800 1810 1820 1830 1840
800 810 820 830 840 850
pF1KA1 LMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLT
:.. . ::::::::: ::::::
XP_011 LLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYKE
1850 1860 1870 1880 1890 1900
>--
initn: 1092 init1: 1092 opt: 1092 Z-score: 718.6 bits: 145.8 E(85289): 2.7e-33
Smith-Waterman score: 1092; 85.3% identity (92.1% similar) in 191 aa overlap (677-867:2629-2819)
650 660 670 680 690 700
pF1KA1 LELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV
:.: :: :::: : :::::::::. .:::
XP_011 LELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKDPEV
2600 2610 2620 2630 2640 2650
710 720 730 740 750 760
pF1KA1 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS
:::::::::::::. :: :: :::.:. :.:::...:..::: .:::::::::::::::
XP_011 LQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDKIEKKGKGKKRRGRRS
2660 2670 2680 2690 2700 2710
770 780 790 800 810 820
pF1KA1 KKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYR
::::::::::::::::::::::::::::::: :::::::: :::::::::::::::::::
XP_011 KKERRRGRKEGEEDQNPPCPRLNGVLMEVEEREVLQDSLDRCYSTPSMYFELPDSFQHYR
2720 2730 2740 2750 2760 2770
830 840 850 860
pF1KA1 SVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
::::::::::::::::::::::::::::::::::: :::::
XP_011 SVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMGVIFPQ
2780 2790 2800 2810
>>NP_001034792 (OMIM: 614000) neuroblastoma breakpoint f (3626 aa)
initn: 17763 init1: 4457 opt: 4461 Z-score: 2911.1 bits: 551.8 E(85289): 2.1e-155
Smith-Waterman score: 4956; 86.4% identity (89.3% similar) in 898 aa overlap (1-823:1-898)
10 20 30 40 50 60
pF1KA1 MVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKY
::::::: :::::::::::::: :.:::::::::::.::::::.:::: ::::.:.::::
NP_001 MVVSAGPWSSEKAEMNILEINETLRPQLAEKKQQFRSLKEKCFLTQLAGFLANRQKKYKY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 RSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDEDEDEDVQVEEAE
::: .:::::::::.:::::::::::::::::::::.: :::::::::::::::::::::
NP_001 RSLYEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSAL
:::::::::::::::::::::::::::::::::::::::::::::::.::::::.:::.:
NP_001 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLA
::::::::::::::.::::::::::::::::::::::::::::::::::::::::.::::
NP_001 VVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQA
::::::::::::::.:::. ::::::.:::::::::::: ::::::::::::::::::::
NP_001 EKKQQFRNLKEKCFLTQLSGFLANQQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDKPDKSQGQDLQEQLA
:::::::::::.::::::::.::::::::::::::.:::::::: .::::::::::::::
NP_001 EELRQYKVLVHAQERELTQLKEKLREGRDASRSLNEHLQALLTPYEPDKSQGQDLQEQLA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 EGCRLTQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 TCSNSHGPYDSNQPHRKTKITFEEDKVDSTLTGSSSHVEWEDAVHIIPENESDDEEEEEK
: ::::: ::::::::::::::::::::::: ::::::::::::::::::::::::::::
NP_001 TYSNSHGSYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIG
550 560 570 580 590 600
610 620 630
pF1KA1 RHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDS-------------------------
:::::::::::::::::::::::::::::::::::
NP_001 RHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSQDRCYSTPSGCLELTDSCQPYRSAF
610 620 630 640 650 660
640
pF1KA1 --------------------------------------------------LDRCYSTPSG
::::::::::
NP_001 YILEQQRVGLAIDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSG
670 680 690 700 710 720
650 660 670 680 690 700
pF1KA1 YLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPE
730 740 750 760 770 780
710 720 730 740 750 760
pF1KA1 VLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR
790 800 810 820 830 840
770 780 790 800 810 820
pF1KA1 SKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHY
:::::::::::::::::::::::. :.. . ::::::::: :::::: .:: :: :
NP_001 SKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPY
850 860 870 880 890 900
830 840 850 860
pF1KA1 RSVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
NP_001 RSAFYVLEQQRVGFAFDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYS
910 920 930 940 950 960
>--
initn: 13289 init1: 1495 opt: 1587 Z-score: 1039.4 bits: 205.5 E(85289): 3.7e-51
Smith-Waterman score: 1643; 43.8% identity (64.8% similar) in 768 aa overlap (147-844:1136-1895)
120 130 140 150 160 170
pF1KA1 RDASRSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLF-----QKLSPENDEDED
.:...:. .. : :... : ::
NP_001 RLSRELLEEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGFAVDMDEI
1110 1120 1130 1140 1150 1160
180 190 200 210 220
pF1KA1 EDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIN
: : :.:. . : :: :. .: .: .:::..: : :. : .::...
NP_001 EKYQ--EVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAV
1170 1180 1190 1200 1210 1220
230 240 250 260 270 280
pF1KA1 ITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNV--SMVVSAGPLSSEKAEM
..::. .. :: ::: ..:: .. . : : . .: :.. . ..
NP_001 YSLEEQYLGLALDVDR-IKKDEEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPS
1230 1240 1250 1260 1270 1280
290 300 310 320 330 340
pF1KA1 NILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNER
. :: .. .: ..: :.:: .: ....: : .. . : :...
NP_001 SCLEQPDSCQPY----GSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRK
1290 1300 1310 1320 1330
350 360 370 380 390
pF1KA1 QFKEEKLAEQLKQAEELRQYK---VLVHSQERELT------QLREKLREGRDASRSLNQH
. .:.. . ..:: . : :: : .: . .: .. . :.: :.:.
NP_001 EGEEDQNPPCPRLSRELLEEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQ
1340 1350 1360 1370 1380 1390
400 410 420 430 440
pF1KA1 LQALLTPDKPDKSQGQDLQEQLAEGC-RLTQHLVQKLSPE--NDNDD-------------
.. .. : . . :...:. .: ::...:... :: .:. :
NP_001 -RVGFAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP
1400 1410 1420 1430 1440 1450
450 460 470
pF1KA1 -------------DE-------DV-QVEVAEKVQKSSAP------REMQKAEEKEVPEDS
.: :: ... :. .... : ::. .. : :: .::
NP_001 DLGQPYSSAVYSLEEQYLGLALDVDRIKKDEEEEEDQDPPCPRLSRELLEVVEPEVLQDS
1460 1470 1480 1490 1500 1510
480 490 500 510 520 530
pF1KA1 LEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL-TG---SSSHVEWEDAVHIIPEN
:..: : :. :: ::. .. ..:: .: .: .: .... . . . . :
NP_001 LDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKER
1520 1530 1540 1550 1560 1570
540 550 560 570 580
pF1KA1 ESDDEE-EEEKGPVSPRNLQESEEEEVP---QESWDEGYSTLSIPPEMLASYQSYSSTFH
. .: ::...: :: .: .:. : :.: :. ::: : :. : : : :.:.
NP_001 RRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFY
1580 1590 1600 1610 1620 1630
590 600 610 620 630 640
pF1KA1 SLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGY
::.:.: .:::. . . : .:::. . ::::::::::: ::::::::::::::::::
NP_001 VLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGY
1640 1650 1660 1670 1680 1690
650 660 670 680 690 700
pF1KA1 LELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV
1700 1710 1720 1730 1740 1750
710 720 730 740 750 760
pF1KA1 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS
1760 1770 1780 1790 1800 1810
770 780 790 800 810 820
pF1KA1 KKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYR
::::::::::::::::::::::. :.. . ::::::::: :::::: .:: :: : ::
NP_001 KKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYR
1820 1830 1840 1850 1860 1870
830 840 850 860
pF1KA1 SVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
:.:: .:.::...:. .:
NP_001 SAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYST
1880 1890 1900 1910 1920 1930
>--
initn: 8777 init1: 1495 opt: 1587 Z-score: 1039.4 bits: 205.5 E(85289): 3.7e-51
Smith-Waterman score: 1640; 43.5% identity (64.3% similar) in 767 aa overlap (147-844:2112-2871)
120 130 140 150 160 170
pF1KA1 RDASRSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLFQKLSPEN---DEDEDED
.:...:. .. : : .. : ::
NP_001 RLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEI
2090 2100 2110 2120 2130 2140
180 190 200 210 220 230
pF1KA1 VQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINIT
. .:.:. . : :: :. .: .: .:::..: : :. : .::... .
NP_001 EKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYS
2150 2160 2170 2180 2190 2200
240 250 260 270 280
pF1KA1 FEEDKVNSALVVDR-ESSHDECQDAVNILPVPGPTSSATNV--SMVVSAGPLSSEKAEMN
.::. .. :: ::: .....: .: : : . .: :.. . .. .
NP_001 LEEQYLGLALDVDRIKKDQEEEEDQGP--PCPRLSRELLEVVEPEVLQDSLDRCYSTPSS
2210 2220 2230 2240 2250
290 300 310 320 330 340
pF1KA1 ILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQ
:: .. .: ..: :.:: .: ....: : .. . : :....
NP_001 CLEQPDSCQPY----GSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKE
2260 2270 2280 2290 2300 2310
350 360 370 380 390
pF1KA1 FKEEKLAEQLKQAEELRQYK---VLVHSQERELT------QLREKLREGRDASRSLNQHL
.:.. . ..:: . : :: : .: . .: .. . :.: :.:.
NP_001 GEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQ-
2320 2330 2340 2350 2360 2370
400 410 420 430 440
pF1KA1 QALLTPDKPDKSQGQDLQEQLAEGC-RLTQHLVQKLSPE--NDNDD--------------
.. :. : . . :...:. .: ::...:... :: .:. :
NP_001 HVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPD
2380 2390 2400 2410 2420 2430
450 460 470
pF1KA1 ---------------------DEDVQVEVAEKVQKSSAP-----REMQKAEEKEVPEDSL
: : . :. . .. : ::. .. : :: .:::
NP_001 LGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQDPPCPRLSRELLEVVEPEVLQDSL
2440 2450 2460 2470 2480 2490
480 490 500 510 520 530
pF1KA1 EECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL-TG---SSSHVEWEDAVHIIPENE
..: : :. :: ::. .. ..:: .: .: .: .... . . . . : .
NP_001 DRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERR
2500 2510 2520 2530 2540 2550
540 550 560 570 580
pF1KA1 SDDEE-EEEKGPVSPRNLQESEEEEVP---QESWDEGYSTLSIPPEMLASYQSYSSTFHS
.: ::...: :: .: .:. : :.: :. ::: : :. : : : :.:.
NP_001 RGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYV
2560 2570 2580 2590 2600 2610
590 600 610 620 630 640
pF1KA1 LEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYL
::.:.: .:::. . . : .:::. . ::::::::::: :::::::::::::::::::
NP_001 LEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYL
2620 2630 2640 2650 2660 2670
650 660 670 680 690 700
pF1KA1 ELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVL
2680 2690 2700 2710 2720 2730
710 720 730 740 750 760
pF1KA1 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSK
2740 2750 2760 2770 2780 2790
770 780 790 800 810 820
pF1KA1 KERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRS
:::::::::::::::::::::. :.. . ::::::::: :::::: .:: :: : :::
NP_001 KERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRS
2800 2810 2820 2830 2840 2850
830 840 850 860
pF1KA1 VFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
.:: .:.::...:. .:
NP_001 AFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTP
2860 2870 2880 2890 2900 2910
>--
initn: 3424 init1: 1483 opt: 1562 Z-score: 1023.1 bits: 202.5 E(85289): 3e-50
Smith-Waterman score: 1562; 64.0% identity (77.5% similar) in 400 aa overlap (451-844:3049-3434)
430 440 450 460 470
pF1KA1 EGCRLTQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPEDSLEE
:. :. :: :. . :: .:::..
NP_001 DVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDR
3020 3030 3040 3050 3060 3070
480 490 500 510 520 530
pF1KA1 CAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLTGSSSHVEWEDAVHIIPENESDDEEE
: : :. :: ::.:.. ..:...: .. . : :. .: :
NP_001 CYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVD--------------MDEIEKYQEVE
3080 3090 3100 3110 3120
540 550 560 570 580 590
pF1KA1 EEKGPVSPRNLQESEEEEVP---QESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVC
:.. : :: .: .:. : :.: :. ::: : :. : : : :.:. ::.:.:
NP_001 EDQDPSCPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYVLEQQHVG
3130 3140 3150 3160 3170 3180
600 610 620 630 640 650
pF1KA1 MAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELPDLGQ
.:::. . . : .:::. . ::::::::::: ::::::::::::::::::::::::::
NP_001 LAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQ
3190 3200 3210 3220 3230 3240
660 670 680 690 700 710
pF1KA1 PYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRC
3250 3260 3270 3280 3290 3300
720 730 740 750 760 770
pF1KA1 YSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGR
3310 3320 3330 3340 3350 3360
780 790 800 810 820 830
pF1KA1 KEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEE
::::::::::::::. :.. . ::::::::: :::::: .:: :: : :::.:: .:.
NP_001 KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELCDSCQPYRSAFYVLEQ
3370 3380 3390 3400 3410 3420
840 850 860
pF1KA1 QHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
:....:. .:
NP_001 QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP
3430 3440 3450 3460 3470 3480
>--
initn: 1327 init1: 1327 opt: 1327 Z-score: 870.1 bits: 174.2 E(85289): 1e-41
Smith-Waterman score: 1327; 85.0% identity (91.8% similar) in 233 aa overlap (581-813:900-1132)
560 570 580 590 600 610
pF1KA1 SEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKE
: :.:. ::.:.: .: :. . . : .:
NP_001 EKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGFAFDMDEIEKYQEVEE
870 880 890 900 910 920
620 630 640 650 660 670
pF1KA1 DQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGL
::. . ::::::::::: ::::::::::::::::::::::::::::::::::::::::::
NP_001 DQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGL
930 940 950 960 970 980
680 690 700 710 720 730
pF1KA1 ALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQP
::::::::::.:::::: ::::::::::::::::::::::::::::::::::::::::::
NP_001 ALDVDRIKKDEEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQP
990 1000 1010 1020 1030 1040
740 750 760 770 780 790
pF1KA1 YGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNG
::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::.
NP_001 YGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSR
1050 1060 1070 1080 1090 1100
800 810 820 830 840 850
pF1KA1 VLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTL
:.: . ::::::::: ::::::
NP_001 ELLEEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGFAVDMDEIEKYQ
1110 1120 1130 1140 1150 1160
>--
initn: 1296 init1: 1296 opt: 1297 Z-score: 850.5 bits: 170.5 E(85289): 1.2e-40
Smith-Waterman score: 1297; 91.8% identity (95.2% similar) in 208 aa overlap (606-813:1901-2108)
580 590 600 610 620 630
pF1KA1 ASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDS
: .:::. . ::::::::::: :::::::
NP_001 DSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDS
1880 1890 1900 1910 1920 1930
640 650 660 670 680 690
pF1KA1 LDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLS
1940 1950 1960 1970 1980 1990
700 710 720 730 740 750
pF1KA1 RELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKK
2000 2010 2020 2030 2040 2050
760 770 780 790 800 810
pF1KA1 GKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMY
:::::::::::::::::::::::::::::::::. :.. . ::::::::: ::::::
NP_001 GKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGC
2060 2070 2080 2090 2100 2110
820 830 840 850 860
pF1KA1 FELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
NP_001 LELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEV
2120 2130 2140 2150 2160 2170
>--
initn: 1105 init1: 1105 opt: 1106 Z-score: 726.1 bits: 147.5 E(85289): 1e-33
Smith-Waterman score: 1106; 95.3% identity (97.1% similar) in 172 aa overlap (606-777:2877-3048)
580 590 600 610 620 630
pF1KA1 ASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDS
: .:::. . ::::::::::: :::::::
NP_001 DSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDS
2850 2860 2870 2880 2890 2900
640 650 660 670 680 690
pF1KA1 LDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLS
2910 2920 2930 2940 2950 2960
700 710 720 730 740 750
pF1KA1 RELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKK
2970 2980 2990 3000 3010 3020
760 770 780 790 800 810
pF1KA1 GKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMY
::::::::::::::::::::::
NP_001 GKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGC
3030 3040 3050 3060 3070 3080
>--
initn: 1096 init1: 1096 opt: 1096 Z-score: 719.6 bits: 146.3 E(85289): 2.4e-33
Smith-Waterman score: 1096; 85.9% identity (92.1% similar) in 191 aa overlap (677-867:3436-3626)
650 660 670 680 690 700
pF1KA1 LELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV
:.: :: :::: : :::::::::. ::::
NP_001 LELCDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEV
3410 3420 3430 3440 3450 3460
710 720 730 740 750 760
pF1KA1 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS
:::::::::::::. :: :: :::.:. :.:::...:..::: .:::::::::::::::
NP_001 LQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDKIEKKGKGKKRRGRRS
3470 3480 3490 3500 3510 3520
770 780 790 800 810 820
pF1KA1 KKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYR
::::::::::::::::::::::::::::::: :::::::: :::::::::::::::::::
NP_001 KKERRRGRKEGEEDQNPPCPRLNGVLMEVEEREVLQDSLDRCYSTPSMYFELPDSFQHYR
3530 3540 3550 3560 3570 3580
830 840 850 860
pF1KA1 SVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
::::::::::::::::::::::::::::::::::: :::::
NP_001 SVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMGVIFPQ
3590 3600 3610 3620
>>NP_001289300 (OMIM: 614000) neuroblastoma breakpoint f (3795 aa)
initn: 17763 init1: 4457 opt: 4461 Z-score: 2910.8 bits: 551.8 E(85289): 2.2e-155
Smith-Waterman score: 4956; 86.4% identity (89.3% similar) in 898 aa overlap (1-823:1-898)
10 20 30 40 50 60
pF1KA1 MVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKY
::::::: :::::::::::::: :.:::::::::::.::::::.:::: ::::.:.::::
NP_001 MVVSAGPWSSEKAEMNILEINETLRPQLAEKKQQFRSLKEKCFLTQLAGFLANRQKKYKY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 RSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDEDEDEDVQVEEAE
::: .:::::::::.:::::::::::::::::::::.: :::::::::::::::::::::
NP_001 RSLYEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSAL
:::::::::::::::::::::::::::::::::::::::::::::::.::::::.:::.:
NP_001 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLA
::::::::::::::.::::::::::::::::::::::::::::::::::::::::.::::
NP_001 VVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQA
::::::::::::::.:::. ::::::.:::::::::::: ::::::::::::::::::::
NP_001 EKKQQFRNLKEKCFLTQLSGFLANQQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDKPDKSQGQDLQEQLA
:::::::::::.::::::::.::::::::::::::.:::::::: .::::::::::::::
NP_001 EELRQYKVLVHAQERELTQLKEKLREGRDASRSLNEHLQALLTPYEPDKSQGQDLQEQLA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 EGCRLTQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 TCSNSHGPYDSNQPHRKTKITFEEDKVDSTLTGSSSHVEWEDAVHIIPENESDDEEEEEK
: ::::: ::::::::::::::::::::::: ::::::::::::::::::::::::::::
NP_001 TYSNSHGSYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIG
550 560 570 580 590 600
610 620 630
pF1KA1 RHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDS-------------------------
:::::::::::::::::::::::::::::::::::
NP_001 RHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSQDRCYSTPSGCLELTDSCQPYRSAF
610 620 630 640 650 660
640
pF1KA1 --------------------------------------------------LDRCYSTPSG
::::::::::
NP_001 YILEQQRVGLAIDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSG
670 680 690 700 710 720
650 660 670 680 690 700
pF1KA1 YLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPE
730 740 750 760 770 780
710 720 730 740 750 760
pF1KA1 VLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR
790 800 810 820 830 840
770 780 790 800 810 820
pF1KA1 SKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHY
:::::::::::::::::::::::. :.. . ::::::::: :::::: .:: :: :
NP_001 SKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPY
850 860 870 880 890 900
830 840 850 860
pF1KA1 RSVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
NP_001 RSAFYVLEQQRVGFAFDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYS
910 920 930 940 950 960
>--
initn: 14767 init1: 1495 opt: 1587 Z-score: 1039.1 bits: 205.5 E(85289): 3.9e-51
Smith-Waterman score: 1640; 43.5% identity (64.3% similar) in 767 aa overlap (147-844:2112-2871)
120 130 140 150 160 170
pF1KA1 RDASRSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLFQKLSPEN---DEDEDED
.:...:. .. : : .. : ::
NP_001 RLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEI
2090 2100 2110 2120 2130 2140
180 190 200 210 220 230
pF1KA1 VQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINIT
. .:.:. . : :: :. .: .: .:::..: : :. : .::... .
NP_001 EKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYS
2150 2160 2170 2180 2190 2200
240 250 260 270 280
pF1KA1 FEEDKVNSALVVDR-ESSHDECQDAVNILPVPGPTSSATNV--SMVVSAGPLSSEKAEMN
.::. .. :: ::: .....: .: : : . .: :.. . .. .
NP_001 LEEQYLGLALDVDRIKKDQEEEEDQGP--PCPRLSRELLEVVEPEVLQDSLDRCYSTPSS
2210 2220 2230 2240 2250
290 300 310 320 330 340
pF1KA1 ILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQ
:: .. .: ..: :.:: .: ....: : .. . : :....
NP_001 CLEQPDSCQPY----GSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKE
2260 2270 2280 2290 2300 2310
350 360 370 380 390
pF1KA1 FKEEKLAEQLKQAEELRQYK---VLVHSQERELT------QLREKLREGRDASRSLNQHL
.:.. . ..:: . : :: : .: . .: .. . :.: :.:.
NP_001 GEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQ-
2320 2330 2340 2350 2360 2370
400 410 420 430 440
pF1KA1 QALLTPDKPDKSQGQDLQEQLAEGC-RLTQHLVQKLSPE--NDNDD--------------
.. :. : . . :...:. .: ::...:... :: .:. :
NP_001 HVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPD
2380 2390 2400 2410 2420 2430
450 460 470
pF1KA1 ---------------------DEDVQVEVAEKVQKSSAP-----REMQKAEEKEVPEDSL
: : . :. . .. : ::. .. : :: .:::
NP_001 LGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQDPPCPRLSRELLEVVEPEVLQDSL
2440 2450 2460 2470 2480 2490
480 490 500 510 520 530
pF1KA1 EECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL-TG---SSSHVEWEDAVHIIPENE
..: : :. :: ::. .. ..:: .: .: .: .... . . . . : .
NP_001 DRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERR
2500 2510 2520 2530 2540 2550
540 550 560 570 580
pF1KA1 SDDEE-EEEKGPVSPRNLQESEEEEVP---QESWDEGYSTLSIPPEMLASYQSYSSTFHS
.: ::...: :: .: .:. : :.: :. ::: : :. : : : :.:.
NP_001 RGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYV
2560 2570 2580 2590 2600 2610
590 600 610 620 630 640
pF1KA1 LEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYL
::.:.: .:::. . . : .:::. . ::::::::::: :::::::::::::::::::
NP_001 LEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYL
2620 2630 2640 2650 2660 2670
650 660 670 680 690 700
pF1KA1 ELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVL
2680 2690 2700 2710 2720 2730
710 720 730 740 750 760
pF1KA1 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSK
2740 2750 2760 2770 2780 2790
770 780 790 800 810 820
pF1KA1 KERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRS
:::::::::::::::::::::. :.. . ::::::::: :::::: .:: :: : :::
NP_001 KERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRS
2800 2810 2820 2830 2840 2850
830 840 850 860
pF1KA1 VFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
.:: .:.::...:. .:
NP_001 AFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTP
2860 2870 2880 2890 2900 2910
>--
initn: 5812 init1: 1495 opt: 1587 Z-score: 1039.1 bits: 205.5 E(85289): 3.9e-51
Smith-Waterman score: 1643; 43.8% identity (64.8% similar) in 768 aa overlap (147-844:1136-1895)
120 130 140 150 160 170
pF1KA1 RDASRSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLF-----QKLSPENDEDED
.:...:. .. : :... : ::
NP_001 RLSRELLEEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGFAVDMDEI
1110 1120 1130 1140 1150 1160
180 190 200 210 220
pF1KA1 EDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIN
: : :.:. . : :: :. .: .: .:::..: : :. : .::...
NP_001 EKYQ--EVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAV
1170 1180 1190 1200 1210 1220
230 240 250 260 270 280
pF1KA1 ITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNV--SMVVSAGPLSSEKAEM
..::. .. :: ::: ..:: .. . : : . .: :.. . ..
NP_001 YSLEEQYLGLALDVDR-IKKDEEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPS
1230 1240 1250 1260 1270 1280
290 300 310 320 330 340
pF1KA1 NILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNER
. :: .. .: ..: :.:: .: ....: : .. . : :...
NP_001 SCLEQPDSCQPY----GSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRK
1290 1300 1310 1320 1330
350 360 370 380 390
pF1KA1 QFKEEKLAEQLKQAEELRQYK---VLVHSQERELT------QLREKLREGRDASRSLNQH
. .:.. . ..:: . : :: : .: . .: .. . :.: :.:.
NP_001 EGEEDQNPPCPRLSRELLEEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQ
1340 1350 1360 1370 1380 1390
400 410 420 430 440
pF1KA1 LQALLTPDKPDKSQGQDLQEQLAEGC-RLTQHLVQKLSPE--NDNDD-------------
.. .. : . . :...:. .: ::...:... :: .:. :
NP_001 -RVGFAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP
1400 1410 1420 1430 1440 1450
450 460 470
pF1KA1 -------------DE-------DV-QVEVAEKVQKSSAP------REMQKAEEKEVPEDS
.: :: ... :. .... : ::. .. : :: .::
NP_001 DLGQPYSSAVYSLEEQYLGLALDVDRIKKDEEEEEDQDPPCPRLSRELLEVVEPEVLQDS
1460 1470 1480 1490 1500 1510
480 490 500 510 520 530
pF1KA1 LEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL-TG---SSSHVEWEDAVHIIPEN
:..: : :. :: ::. .. ..:: .: .: .: .... . . . . :
NP_001 LDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKER
1520 1530 1540 1550 1560 1570
540 550 560 570 580
pF1KA1 ESDDEE-EEEKGPVSPRNLQESEEEEVP---QESWDEGYSTLSIPPEMLASYQSYSSTFH
. .: ::...: :: .: .:. : :.: :. ::: : :. : : : :.:.
NP_001 RRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFY
1580 1590 1600 1610 1620 1630
590 600 610 620 630 640
pF1KA1 SLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGY
::.:.: .:::. . . : .:::. . ::::::::::: ::::::::::::::::::
NP_001 VLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGY
1640 1650 1660 1670 1680 1690
650 660 670 680 690 700
pF1KA1 LELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV
1700 1710 1720 1730 1740 1750
710 720 730 740 750 760
pF1KA1 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS
1760 1770 1780 1790 1800 1810
770 780 790 800 810 820
pF1KA1 KKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYR
::::::::::::::::::::::. :.. . ::::::::: :::::: .:: :: : ::
NP_001 KKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYR
1820 1830 1840 1850 1860 1870
830 840 850 860
pF1KA1 SVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
:.:: .:.::...:. .:
NP_001 SAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYST
1880 1890 1900 1910 1920 1930
>--
initn: 4340 init1: 1492 opt: 1580 Z-score: 1034.5 bits: 204.7 E(85289): 6.9e-51
Smith-Waterman score: 1580; 57.3% identity (73.3% similar) in 480 aa overlap (375-844:2892-3359)
350 360 370 380 390 400
pF1KA1 ERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTP
::: . .: . .: . : :
NP_001 QHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP
2870 2880 2890 2900 2910 2920
410 420 430 440 450 460
pF1KA1 D--KPDKSQGQDLQEQLAEGCRLTQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREM
: .: .: .:.:: : : ..: :....:: : ... ::.
NP_001 DLGQPYSSAVYSLEEQYL-GLALDVDRIKK-----DQEEEED-QGPPCPRLS-----REL
2930 2940 2950 2960
470 480 490 500 510
pF1KA1 QKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL-TG---SSSHV
.. : :: .:::..: : :. :: ::. .. ..:: .: .: .: ....
NP_001 LEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKG
2970 2980 2990 3000 3010 3020
520 530 540 550 560 570
pF1KA1 EWEDAVHIIPENESDDEE-EEEKGPVSPRNLQESEEEEVP---QESWDEGYSTLSIPPEM
. . . . : . .: ::...: :: .: .:. : :.: :. ::: : :.
NP_001 KKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLEL
3030 3040 3050 3060 3070 3080
580 590 600 610 620 630
pF1KA1 LASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQD
: : : :.:. ::.:.: .:::. . . : .:::. . ::::::::::: ::::::
NP_001 TDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQD
3090 3100 3110 3120 3130 3140
640 650 660 670 680 690
pF1KA1 SLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRL
::::::::::::::::::::::::::::::::::::::::::::::.:::::: ::::::
NP_001 SLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDEEEEEDQDPPCPRL
3150 3160 3170 3180 3190 3200
700 710 720 730 740 750
pF1KA1 SRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEK
3210 3220 3230 3240 3250 3260
760 770 780 790 800 810
pF1KA1 KGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSM
::::::::::::::::::::::::::::::::::. :.. . ::::::::: ::::::
NP_001 KGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSG
3270 3280 3290 3300 3310 3320
820 830 840 850 860
pF1KA1 YFELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
:.:: :: : :::.:: .:.::...:. .:
NP_001 YLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPE
3330 3340 3350 3360 3370 3380
>--
initn: 1989 init1: 1417 opt: 1460 Z-score: 956.4 bits: 190.2 E(85289): 1.6e-46
Smith-Waterman score: 1593; 61.1% identity (74.2% similar) in 442 aa overlap (451-867:3368-3795)
430 440 450 460 470
pF1KA1 EGCRLTQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPEDSLEE
:. : : :: :. .: :: .:::..
NP_001 QPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDR
3340 3350 3360 3370 3380 3390
480 490 500 510 520 530
pF1KA1 CAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLTGSSSHVEWEDAVHIIPENESDDEEE
: : :. : .::. .. ..::. . .: . . ..:.:::
NP_001 CYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD--------------VDRIKKDQEEE
3400 3410 3420 3430 3440
540 550 560 570 580 590
pF1KA1 EEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVC
:..:: :: .: : : :: :.: :. ::: : :. : : :.:.:..:::..:
NP_001 EDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVG
3450 3460 3470 3480 3490 3500
600 610 620 630
pF1KA1 MAVDIG-------------------RHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDS
...:.: :.: . .:::. :::::::::::::::::::
NP_001 FSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDS
3510 3520 3530 3540 3550 3560
640 650 660 670 680 690
pF1KA1 LDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLS
:::::::::: ::: : ::: :: : ::.: .:::.:.:.:.: :: :::: : :::::
NP_001 LDRCYSTPSGCLELCDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLS
3570 3580 3590 3600 3610 3620
700 710 720 730 740 750
pF1KA1 RELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKK
::::. :::::::::::::::::. :: :: :::.:. :.:::...:..::: .::::
NP_001 RELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDKIEKK
3630 3640 3650 3660 3670 3680
760 770 780 790 800 810
pF1KA1 GKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMY
:::::::::::::::::::::::::::::::::::::::::: :::::::: ::::::::
NP_001 GKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEREVLQDSLDRCYSTPSMY
3690 3700 3710 3720 3730 3740
820 830 840 850 860
pF1KA1 FELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
:::::::::::::::::::::::::::::::::::::::::::::: :::::
NP_001 FELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMGVIFPQ
3750 3760 3770 3780 3790
>--
initn: 1327 init1: 1327 opt: 1327 Z-score: 869.8 bits: 174.2 E(85289): 1e-41
Smith-Waterman score: 1327; 85.0% identity (91.8% similar) in 233 aa overlap (581-813:900-1132)
560 570 580 590 600 610
pF1KA1 SEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKE
: :.:. ::.:.: .: :. . . : .:
NP_001 EKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGFAFDMDEIEKYQEVEE
870 880 890 900 910 920
620 630 640 650 660 670
pF1KA1 DQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGL
::. . ::::::::::: ::::::::::::::::::::::::::::::::::::::::::
NP_001 DQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGL
930 940 950 960 970 980
680 690 700 710 720 730
pF1KA1 ALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQP
::::::::::.:::::: ::::::::::::::::::::::::::::::::::::::::::
NP_001 ALDVDRIKKDEEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQP
990 1000 1010 1020 1030 1040
740 750 760 770 780 790
pF1KA1 YGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNG
::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::.
NP_001 YGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSR
1050 1060 1070 1080 1090 1100
800 810 820 830 840 850
pF1KA1 VLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTL
:.: . ::::::::: ::::::
NP_001 ELLEEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGFAVDMDEIEKYQ
1110 1120 1130 1140 1150 1160
>--
initn: 1296 init1: 1296 opt: 1297 Z-score: 850.2 bits: 170.6 E(85289): 1.3e-40
Smith-Waterman score: 1297; 91.8% identity (95.2% similar) in 208 aa overlap (606-813:1901-2108)
580 590 600 610 620 630
pF1KA1 ASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDS
: .:::. . ::::::::::: :::::::
NP_001 DSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDS
1880 1890 1900 1910 1920 1930
640 650 660 670 680 690
pF1KA1 LDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLS
1940 1950 1960 1970 1980 1990
700 710 720 730 740 750
pF1KA1 RELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKK
2000 2010 2020 2030 2040 2050
760 770 780 790 800 810
pF1KA1 GKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMY
:::::::::::::::::::::::::::::::::. :.. . ::::::::: ::::::
NP_001 GKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGC
2060 2070 2080 2090 2100 2110
820 830 840 850 860
pF1KA1 FELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
NP_001 LELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEV
2120 2130 2140 2150 2160 2170
>>NP_001032590 (OMIM: 613998) putative neuroblastoma bre (942 aa)
initn: 6108 init1: 4439 opt: 4443 Z-score: 2908.0 bits: 549.3 E(85289): 3.1e-155
Smith-Waterman score: 5001; 86.8% identity (89.8% similar) in 899 aa overlap (1-824:1-899)
10 20 30 40 50 60
pF1KA1 MVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKY
::::::: ::::::::::::::::.:::::.:::: ::::.::.:::: ::::.:.::::
NP_001 MVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFVNLKERCFLTQLAGFLANRQKKYKY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
:::::::. ::::::::::::::::::::::::::::::::::::::::.:::.::::::
NP_001 EECKDLIRFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLKEKLQEGRDAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 RSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDEDEDEDVQVEEAE
::::.::::::: :.:::::::::::::::::::::.: ::::::::::::::::::: :
NP_001 RSLNEHLQALLTLDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSAL
:: .:::::::::::::::::::::::::::::::::::::::::::.::::::.:::.:
NP_001 KVQKSSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLA
::::::::::::::.::: :::::::::::::::::::::::::::::::::::::::::
NP_001 VVDRESSHDECQDALNILSVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQA
::::::::::::::.:::: ::::.:::::::::::::::::::::::::::::::::::
NP_001 EKKQQFRNLKEKCFLTQLAGFLANRQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDKPDKSQGQDLQEQLA
:::::::::::.::::::::::::::::::: :::.:::::::::.::::::::::::::
NP_001 EELRQYKVLVHTQERELTQLREKLREGRDASLSLNEHLQALLTPDEPDKSQGQDLQEQLA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 EGCRLTQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 TCSNSHGPYDSNQPHRKTKITFEEDKVDSTLTGSSSHVEWEDAVHIIPENESDDEEEEEK
: :::::::::::::::::::::::::::.: ::::::::::::::::::::::::::::
NP_001 TYSNSHGPYDSNQPHRKTKITFEEDKVDSALIGSSSHVEWEDAVHIIPENESDDEEEEEK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIG
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
NP_001 GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYKSYSSTFHSLEEQQVCMAVDIG
550 560 570 580 590 600
610 620 630 640
pF1KA1 RHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSG---------------
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 RHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAF
610 620 630 640 650 660
pF1KA1 ------------------------------------------------------------
NP_001 YILEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSG
670 680 690 700 710 720
650 660 670 680 690 700
pF1KA1 YLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPE
730 740 750 760 770 780
710 720 730 740 750 760
pF1KA1 VLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR
:::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
NP_001 VLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKIRRGRR
790 800 810 820 830 840
770 780 790 800 810 820
pF1KA1 SKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHY
:::.::::::::::::::::::::.:::::::::::::::: :::::::: :: :::::
NP_001 SKKKRRRGRKEGEEDQNPPCPRLNSVLMEVEEPEVLQDSLDRCYSTPSMYCELRDSFQHY
850 860 870 880 890 900
830 840 850 860
pF1KA1 RSVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
NP_001 RSVFYSFEEQHISFALDMDNRFFTLTVTSLYLVFQMGVIFPQ
910 920 930 940
>>NP_001032764 (OMIM: 613999) neuroblastoma breakpoint f (942 aa)
initn: 6078 init1: 4418 opt: 4422 Z-score: 2894.3 bits: 546.8 E(85289): 1.8e-154
Smith-Waterman score: 5062; 87.7% identity (90.2% similar) in 899 aa overlap (1-824:1-899)
10 20 30 40 50 60
pF1KA1 MVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKY
::::::: ::::::::::::::::.:::::.:::: ::::.::.:::: ::::.:.::::
NP_001 MVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFGNLKERCFLTQLAGFLANRQKKYKY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
:::::::: ::::::::::::::::::::::::::::::::::::::::.::::::::::
NP_001 EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLKEKLREGRDAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 RSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDEDEDEDVQVEEAE
::::.:::::::::.:::::::::::::::::::::.: ::::::::::::::::::: :
NP_001 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSAL
::::::::::::::::::: :::::::::::::::::::::::::::.::::::.:::.:
NP_001 KVLESSAPREVQKAEESKVAEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLA
::::::::::::::.::::::::::::::::::::::::::::::::::::::::.::::
NP_001 VVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQA
::::::::::::::.:::: ::::::::::::::::::: ::::::::::::::::::::
NP_001 EKKQQFRNLKEKCFLTQLAGFLANQQNKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDKPDKSQGQDLQEQLA
:::::::::::.:::::::::::::::::::::::.:::::::::.::::::::::::::
NP_001 EELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 EGCRLTQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI
:::::.::::::::::::::::::::.:::::::::::::::::::::::::::::::::
NP_001 EGCRLAQHLVQKLSPENDNDDDEDVQIEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 TCSNSHGPYDSNQPHRKTKITFEEDKVDSTLTGSSSHVEWEDAVHIIPENESDDEEEEEK
: ::::::::::::::::::::::::::::: ::::::: ::::::::::::::::::::
NP_001 TYSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEREDAVHIIPENESDDEEEEEK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIG
::::::::::::::::::::::::::: ::::::::::.:::::::::::::::::::::
NP_001 GPVSPRNLQESEEEEVPQESWDEGYSTPSIPPEMLASYKSYSSTFHSLEEQQVCMAVDIG
550 560 570 580 590 600
610 620 630 640
pF1KA1 RHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSG---------------
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 RHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAF
610 620 630 640 650 660
pF1KA1 ------------------------------------------------------------
NP_001 YVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLGRWYSTPSG
670 680 690 700 710 720
650 660 670 680 690 700
pF1KA1 YLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPE
::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
NP_001 YLELPDLGQPYSSAVYSLEEQYLGLALDLDRIKKDQEEEEDQGPPCPRLSRELLEVVEPE
730 740 750 760 770 780
710 720 730 740 750 760
pF1KA1 VLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR
790 800 810 820 830 840
770 780 790 800 810 820
pF1KA1 SKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHY
850 860 870 880 890 900
830 840 850 860
pF1KA1 RSVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
NP_001 RSVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ
910 920 930 940
>--
initn: 280 init1: 280 opt: 280 Z-score: 196.8 bits: 47.6 E(85289): 0.00032
Smith-Waterman score: 280; 100.0% identity (100.0% similar) in 43 aa overlap (825-867:900-942)
800 810 820 830 840 850
pF1KA1 VEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLTVTS
::::::::::::::::::::::::::::::
NP_001 VEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLTVTS
870 880 890 900 910 920
860
pF1KA1 LHLVFQMEVIFPQ
:::::::::::::
NP_001 LHLVFQMEVIFPQ
930 940
867 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 06:54:04 2016 done: Sat Nov 5 06:54:06 2016
Total Scan time: 13.500 Total Display time: 0.770
Function used was FASTA [36.3.4 Apr, 2011]