FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1732, 2642 aa 1>>>pF1KA1732 2642 - 2642 aa - 2642 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.2869+/-0.00126; mu= -9.9795+/- 0.076 mean_var=428.1346+/-88.994, 0's: 0 Z-trim(113.0): 48 B-trim: 109 in 1/52 Lambda= 0.061985 statistics sampled from 13661 (13694) to 13661 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.709), E-opt: 0.2 (0.421), width: 16 Scan time: 8.350 The best scores are: opt bits E(32554) CCDS2749.2 SETD2 gene_id:29072|Hs108|chr3 (2564) 10784 980.7 0 >>CCDS2749.2 SETD2 gene_id:29072|Hs108|chr3 (2564 aa) initn: 10784 init1: 10784 opt: 10784 Z-score: 5223.0 bits: 980.7 E(32554): 0 Smith-Waterman score: 17020; 97.0% identity (97.0% similar) in 2642 aa overlap (1-2642:1-2564) 10 20 30 40 50 60 pF1KA1 MKQLQPQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 MKQLQPQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 TKVNLEEQGRQKVSFSFSLTKKTLQNRFLTALGNEKQSDTPNPPAVPLQVDSTPKMKMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 TKVNLEEQGRQKVSFSFSLTKKTLQNRFLTALGNEKQSDTPNPPAVPLQVDSTPKMKMEI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 GDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASPPTHAAPLPAVIAES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 GDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASPPTHAAPLPAVIAES 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 TTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 TTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 PPIIIVPESLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 PPIIIVPESLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 SCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 SCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 EDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 EDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 RSERSHYYDSDRRYHRSSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 RSERSHYYDSDRRYHRSSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSY 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 RDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEAIKRCCSPPNELGFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 RDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEAIKRCCSPPNELGFR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 RGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 RGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSEL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 RMINKNPEREKAGSPAPSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 RMINKNPEREKAGSPAPSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 DQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSELSPLVKACMLSSNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 DQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSELSPLVKACMLSSNG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 FQNISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 FQNISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 TRVSCCKTKDSDIYCTLNDSNPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 TRVSCCKTKDSDIYCTLNDSNPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 LTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSLPPGIKVDSLTLLKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 LTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSLPPGIKVDSLTLLKC 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 GENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 GENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQ 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 EAQEEGNSILPERRGRPEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 EAQEEGNSILPERRGRPEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALK 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 CDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRLQSVVVVPKNSTLPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 CDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRLQSVVVVPKNSTLPM 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA1 EETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 EETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKN 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA1 PEISFTQSSRKQIDNRLPELSHPQSDGVDSTSHTDVKSDPLGHPNSEETVKAKIPSRQQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 PEISFTQSSRKQIDNRLPELSHPQSDGVDSTSHTDVKSDPLGHPNSEETVKAKIPSRQQE 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA1 ELPIYSSDFEDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHVDGLHSSEELRNLGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 ELPIYSSDFEDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHVDGLHSSEELRNLGW 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA1 DFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 DFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVY 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA1 DRTQGQVPDSLTDDREEEENWDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 DRTQGQVPDSLTDDREEEENWDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDT 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KA1 LAVNEKKDFSKNLEKNDIKDRGPLKKRRQEIESDSESDGELQDRKKVRVEVEQGETSVPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 LAVNEKKDFSKNLEKNDIKDRGPLKKRRQEIESDSESDGELQDRKKVRVEVEQGETSVPP 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KA1 GSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 GSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCE 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KA1 CTPLSKDERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 CTPLSKDERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKK 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KA1 GWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDETESRSIA ::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 GWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDE------- 1570 1580 1590 1600 1610 1630 1640 1650 1660 1670 1680 pF1KA1 QAGVQWQDLGSLQPLPPGFKRFSCLSFLSSWDYRRPPPRLANFCIFSRDGVSPRWPGWSR CCDS27 ------------------------------------------------------------ 1690 1700 1710 1720 1730 1740 pF1KA1 SPDLTKALRLQIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSEL ::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 -----------IIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSEL 1620 1630 1640 1650 1660 1750 1760 1770 1780 1790 1800 pF1KA1 TFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSRKKDSVDGELEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 TFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSRKKDSVDGELEAL 1670 1680 1690 1700 1710 1720 1810 1820 1830 1840 1850 1860 pF1KA1 MENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHSQSCLKSFLERHGLSLLWIW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 MENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHSQSCLKSFLERHGLSLLWIW 1730 1740 1750 1760 1770 1780 1870 1880 1890 1900 1910 1920 pF1KA1 MAELGDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPPLSEGDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 MAELGDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPPLSEGDG 1790 1800 1810 1820 1830 1840 1930 1940 1950 1960 1970 1980 pF1KA1 YSSENTSRAHTPLNTPDPSTKLSTEADTDTPKKLMFRRLKIISENSMDSAISDATSELEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 YSSENTSRAHTPLNTPDPSTKLSTEADTDTPKKLMFRRLKIISENSMDSAISDATSELEG 1850 1860 1870 1880 1890 1900 1990 2000 2010 2020 2030 2040 pF1KA1 KDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIEASKLPTSEPEADAEIEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 KDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIEASKLPTSEPEADAEIEP 1910 1920 1930 1940 1950 1960 2050 2060 2070 2080 2090 2100 pF1KA1 KESNGTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 KESNGTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKEV 1970 1980 1990 2000 2010 2020 2110 2120 2130 2140 2150 2160 pF1KA1 YRIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRRSSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 YRIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRRSSLS 2030 2040 2050 2060 2070 2080 2170 2180 2190 2200 2210 2220 pF1KA1 PPSSAYERGTKRPDDRYDTPTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 PPSSAYERGTKRPDDRYDTPTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQ 2090 2100 2110 2120 2130 2140 2230 2240 2250 2260 2270 2280 pF1KA1 NLGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCSPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 NLGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCSPAP 2150 2160 2170 2180 2190 2200 2290 2300 2310 2320 2330 2340 pF1KA1 YDHAQPLVGHSTEPLSAPPPVPVVPHVAAPVEVSSSQYVAQSDGVVHQDSSVAVLPVPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 YDHAQPLVGHSTEPLSAPPPVPVVPHVAAPVEVSSSQYVAQSDGVVHQDSSVAVLPVPAP 2210 2220 2230 2240 2250 2260 2350 2360 2370 2380 2390 2400 pF1KA1 GPVQGQNYSVWDSNQQSVSVQQQYSPAQSQATIYYQGQTCPTVYGVTSPYSQTTPPIVQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 GPVQGQNYSVWDSNQQSVSVQQQYSPAQSQATIYYQGQTCPTVYGVTSPYSQTTPPIVQS 2270 2280 2290 2300 2310 2320 2410 2420 2430 2440 2450 2460 pF1KA1 YAQPSLQYIQGQQIFTAHPQGVVVQPAAAVTTIVAPGQPQPLQPSEMVVTNNLLDLPPPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 YAQPSLQYIQGQQIFTAHPQGVVVQPAAAVTTIVAPGQPQPLQPSEMVVTNNLLDLPPPS 2330 2340 2350 2360 2370 2380 2470 2480 2490 2500 2510 2520 pF1KA1 PPKPKTIVLPPNWKTARDPEGKIYYYHVITRQTQWDPPTWESPGDDASLEHEAEMDLGTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 PPKPKTIVLPPNWKTARDPEGKIYYYHVITRQTQWDPPTWESPGDDASLEHEAEMDLGTP 2390 2400 2410 2420 2430 2440 2530 2540 2550 2560 2570 2580 pF1KA1 TYDENPMKASKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 TYDENPMKASKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTT 2450 2460 2470 2480 2490 2500 2590 2600 2610 2620 2630 2640 pF1KA1 EDFKHLARKLTHGVMNKELKYCKNPEDLECNENVKHKTKEYIKKYMQKFGAVYKPKEDTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS27 EDFKHLARKLTHGVMNKELKYCKNPEDLECNENVKHKTKEYIKKYMQKFGAVYKPKEDTE 2510 2520 2530 2540 2550 2560 pF1KA1 LE :: CCDS27 LE 2642 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 21:55:45 2016 done: Wed Nov 2 21:55:47 2016 Total Scan time: 8.350 Total Display time: 0.330 Function used was FASTA [36.3.4 Apr, 2011]