FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1867, 778 aa 1>>>pF1KA1867 778 - 778 aa - 778 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.1182+/-0.000544; mu= 12.0135+/- 0.033 mean_var=192.7685+/-40.193, 0's: 0 Z-trim(113.9): 314 B-trim: 876 in 2/53 Lambda= 0.092375 statistics sampled from 22937 (23394) to 22937 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.629), E-opt: 0.2 (0.274), width: 16 Scan time: 11.210 The best scores are: opt bits E(85289) XP_011541333 (OMIM: 607761,612581) PREDICTED: kin ( 778) 5140 699.0 2e-200 XP_016873909 (OMIM: 607761,612581) PREDICTED: kin ( 778) 5140 699.0 2e-200 NP_115920 (OMIM: 607761,612581) kin of IRRE-like p ( 778) 5140 699.0 2e-200 XP_011541332 (OMIM: 607761,612581) PREDICTED: kin ( 784) 5012 681.9 2.7e-195 NP_001155179 (OMIM: 607761,612581) kin of IRRE-lik ( 600) 3749 513.5 1.1e-144 XP_011541330 (OMIM: 607761,612581) PREDICTED: kin ( 803) 3749 513.6 1.3e-144 XP_016873907 (OMIM: 607761,612581) PREDICTED: kin ( 803) 3749 513.6 1.3e-144 XP_011541329 (OMIM: 607761,612581) PREDICTED: kin ( 803) 3749 513.6 1.3e-144 XP_011541328 (OMIM: 607761,612581) PREDICTED: kin ( 809) 3621 496.6 1.8e-139 NP_001288026 (OMIM: 607761,612581) kin of IRRE-lik ( 766) 3446 473.2 1.8e-132 XP_011541335 (OMIM: 607761,612581) PREDICTED: kin ( 766) 3446 473.2 1.8e-132 XP_016873908 (OMIM: 607761,612581) PREDICTED: kin ( 791) 3446 473.2 1.8e-132 XP_011541334 (OMIM: 607761,612581) PREDICTED: kin ( 772) 3318 456.2 2.4e-127 NP_060710 (OMIM: 607428) kin of IRRE-like protein ( 757) 1971 276.7 2.6e-73 NP_001273278 (OMIM: 607428) kin of IRRE-like prote ( 657) 1610 228.5 7.3e-59 NP_115499 (OMIM: 607762) kin of IRRE-like protein ( 633) 1427 204.1 1.6e-51 XP_011525665 (OMIM: 607762) PREDICTED: kin of IRRE ( 708) 1424 203.7 2.2e-51 NP_954649 (OMIM: 607762) kin of IRRE-like protein ( 708) 1424 203.7 2.2e-51 XP_011525664 (OMIM: 607762) PREDICTED: kin of IRRE ( 708) 1424 203.7 2.2e-51 XP_016882837 (OMIM: 607762) PREDICTED: kin of IRRE ( 673) 1358 194.9 9.5e-49 NP_954648 (OMIM: 607762) kin of IRRE-like protein ( 583) 1278 184.2 1.4e-45 NP_001316459 (OMIM: 607762) kin of IRRE-like prote ( 658) 1275 183.8 2e-45 XP_011525667 (OMIM: 607762) PREDICTED: kin of IRRE ( 658) 1275 183.8 2e-45 XP_005245362 (OMIM: 607428) PREDICTED: kin of IRRE ( 773) 1272 183.5 2.9e-45 XP_016873611 (OMIM: 607313,608630) PREDICTED: roun (1364) 361 62.4 1.5e-08 NP_071765 (OMIM: 607313,608630) roundabout homolog (1386) 361 62.4 1.5e-08 NP_067012 (OMIM: 609743) cell adhesion molecule 3 ( 432) 347 59.9 2.6e-08 XP_005258677 (OMIM: 609744) PREDICTED: cell adhesi ( 345) 345 59.6 2.7e-08 NP_001120645 (OMIM: 609743) cell adhesion molecule ( 398) 346 59.8 2.7e-08 NP_004637 (OMIM: 256300,602716) nephrin precursor (1241) 353 61.3 3e-08 XP_016881941 (OMIM: 609744) PREDICTED: cell adhesi ( 369) 342 59.2 3.7e-08 NP_660339 (OMIM: 609744) cell adhesion molecule 4 ( 388) 342 59.2 3.8e-08 XP_011508699 (OMIM: 269400,605158) PREDICTED: pero (1296) 343 60.0 7.7e-08 XP_011508698 (OMIM: 269400,605158) PREDICTED: pero (1296) 343 60.0 7.7e-08 XP_005264764 (OMIM: 269400,605158) PREDICTED: pero (1455) 343 60.0 8.3e-08 NP_036425 (OMIM: 269400,605158) peroxidasin homolo (1479) 343 60.0 8.4e-08 NP_001230210 (OMIM: 601662) CD166 antigen isoform ( 555) 315 55.8 5.9e-07 NP_001618 (OMIM: 601662) CD166 antigen isoform 1 p ( 583) 315 55.8 6e-07 NP_001230209 (OMIM: 601662) CD166 antigen isoform ( 570) 304 54.4 1.6e-06 XP_016862473 (OMIM: 602430) PREDICTED: roundabout (1596) 306 55.1 2.7e-06 XP_016862472 (OMIM: 602430) PREDICTED: roundabout (1612) 306 55.1 2.7e-06 NP_002932 (OMIM: 602430) roundabout homolog 1 isof (1651) 306 55.1 2.8e-06 XP_016861551 (OMIM: 609938) PREDICTED: cell adhesi ( 449) 295 53.0 3.2e-06 NP_001139317 (OMIM: 602430) roundabout homolog 1 i (1551) 302 54.6 3.8e-06 XP_011532282 (OMIM: 602430) PREDICTED: roundabout (1590) 302 54.6 3.9e-06 XP_011532281 (OMIM: 602430) PREDICTED: roundabout (1599) 302 54.6 3.9e-06 NP_598334 (OMIM: 602430) roundabout homolog 1 isof (1606) 302 54.6 3.9e-06 XP_006713340 (OMIM: 602430) PREDICTED: roundabout (1615) 302 54.6 3.9e-06 XP_016862471 (OMIM: 602430) PREDICTED: roundabout (1626) 302 54.6 3.9e-06 XP_011532280 (OMIM: 602430) PREDICTED: roundabout (1645) 302 54.6 4e-06 >>XP_011541333 (OMIM: 607761,612581) PREDICTED: kin of I (778 aa) initn: 5140 init1: 5140 opt: 5140 Z-score: 3719.4 bits: 699.0 E(85289): 2e-200 Smith-Waterman score: 5140; 100.0% identity (100.0% similar) in 778 aa overlap (1-778:1-778) 10 20 30 40 50 60 pF1KA1 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 AVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 LMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPD 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 LRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSS 670 680 690 700 710 720 730 740 750 760 770 pF1KA1 SFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV 730 740 750 760 770 >>XP_016873909 (OMIM: 607761,612581) PREDICTED: kin of I (778 aa) initn: 5140 init1: 5140 opt: 5140 Z-score: 3719.4 bits: 699.0 E(85289): 2e-200 Smith-Waterman score: 5140; 100.0% identity (100.0% similar) in 778 aa overlap (1-778:1-778) 10 20 30 40 50 60 pF1KA1 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 AVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 LMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPD 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 LRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSS 670 680 690 700 710 720 730 740 750 760 770 pF1KA1 SFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV 730 740 750 760 770 >>NP_115920 (OMIM: 607761,612581) kin of IRRE-like prote (778 aa) initn: 5140 init1: 5140 opt: 5140 Z-score: 3719.4 bits: 699.0 E(85289): 2e-200 Smith-Waterman score: 5140; 100.0% identity (100.0% similar) in 778 aa overlap (1-778:1-778) 10 20 30 40 50 60 pF1KA1 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 AVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 AVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 LMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 LMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPD 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 LRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 LRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSS 670 680 690 700 710 720 730 740 750 760 770 pF1KA1 SFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 SFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV 730 740 750 760 770 >>XP_011541332 (OMIM: 607761,612581) PREDICTED: kin of I (784 aa) initn: 5012 init1: 5012 opt: 5012 Z-score: 3627.1 bits: 681.9 E(85289): 2.7e-195 Smith-Waterman score: 5012; 100.0% identity (100.0% similar) in 760 aa overlap (19-778:25-784) 10 20 30 40 50 pF1KA1 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQP :::::::::::::::::::::::::::::::::::: XP_011 MDASLGAGLRCSGIASSPLRMQQNELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KA1 QDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA1 LRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADN 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA1 AKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAI 190 200 210 220 230 240 240 250 260 270 280 290 pF1KA1 PGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA1 SGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIF 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA1 SCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTL 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA1 TVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETIS 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA1 TEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPM 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA1 AVIIGVAVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVIIGVAVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEE 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA1 HSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISL 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA1 SSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRG 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA1 SLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRM 730 740 750 760 770 780 pF1KA1 QTHV :::: XP_011 QTHV >>NP_001155179 (OMIM: 607761,612581) kin of IRRE-like pr (600 aa) initn: 3749 init1: 3749 opt: 3749 Z-score: 2718.8 bits: 513.5 E(85289): 1.1e-144 Smith-Waterman score: 3749; 99.5% identity (99.6% similar) in 569 aa overlap (1-569:1-569) 10 20 30 40 50 60 pF1KA1 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 AVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQ :::::::::::::::::::::::::. : NP_001 AVGAGVAFLVLMATIVAFCCARSQRSTGGRSGISGRGTEKKARLRLPRRASKQECNEQGS 550 560 570 580 590 600 >>XP_011541330 (OMIM: 607761,612581) PREDICTED: kin of I (803 aa) initn: 5132 init1: 3749 opt: 3749 Z-score: 2717.4 bits: 513.6 E(85289): 1.3e-144 Smith-Waterman score: 5080; 96.9% identity (96.9% similar) in 803 aa overlap (1-778:1-803) 10 20 30 40 50 60 pF1KA1 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV 490 500 510 520 530 540 550 560 570 pF1KA1 AVGAGVAFLVLMATIVAFCCARSQR-------------------------NLKGVVSAKN ::::::::::::::::::::::::: :::::::::: XP_011 AVGAGVAFLVLMATIVAFCCARSQRSTGGRSGISGRGTEKKARLRLPRRANLKGVVSAKN 550 560 570 580 590 600 580 590 600 610 620 630 pF1KA1 DIRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DIRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTN 610 620 630 640 650 660 640 650 660 670 680 690 pF1KA1 GYYSVNTFKEHHSTPTISLSSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GYYSVNTFKEHHSTPTISLSSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRF 670 680 690 700 710 720 700 710 720 730 740 750 pF1KA1 VLGMGSSSIELCEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLGMGSSSIELCEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSH 730 740 750 760 770 780 760 770 pF1KA1 HSQSSSQNSDPSRPLQRRMQTHV ::::::::::::::::::::::: XP_011 HSQSSSQNSDPSRPLQRRMQTHV 790 800 >>XP_016873907 (OMIM: 607761,612581) PREDICTED: kin of I (803 aa) initn: 5132 init1: 3749 opt: 3749 Z-score: 2717.4 bits: 513.6 E(85289): 1.3e-144 Smith-Waterman score: 5080; 96.9% identity (96.9% similar) in 803 aa overlap (1-778:1-803) 10 20 30 40 50 60 pF1KA1 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV 490 500 510 520 530 540 550 560 570 pF1KA1 AVGAGVAFLVLMATIVAFCCARSQR-------------------------NLKGVVSAKN ::::::::::::::::::::::::: :::::::::: XP_016 AVGAGVAFLVLMATIVAFCCARSQRSTGGRSGISGRGTEKKARLRLPRRANLKGVVSAKN 550 560 570 580 590 600 580 590 600 610 620 630 pF1KA1 DIRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DIRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTN 610 620 630 640 650 660 640 650 660 670 680 690 pF1KA1 GYYSVNTFKEHHSTPTISLSSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GYYSVNTFKEHHSTPTISLSSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRF 670 680 690 700 710 720 700 710 720 730 740 750 pF1KA1 VLGMGSSSIELCEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLGMGSSSIELCEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSH 730 740 750 760 770 780 760 770 pF1KA1 HSQSSSQNSDPSRPLQRRMQTHV ::::::::::::::::::::::: XP_016 HSQSSSQNSDPSRPLQRRMQTHV 790 800 >>XP_011541329 (OMIM: 607761,612581) PREDICTED: kin of I (803 aa) initn: 5132 init1: 3749 opt: 3749 Z-score: 2717.4 bits: 513.6 E(85289): 1.3e-144 Smith-Waterman score: 5080; 96.9% identity (96.9% similar) in 803 aa overlap (1-778:1-803) 10 20 30 40 50 60 pF1KA1 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV 490 500 510 520 530 540 550 560 570 pF1KA1 AVGAGVAFLVLMATIVAFCCARSQR-------------------------NLKGVVSAKN ::::::::::::::::::::::::: :::::::::: XP_011 AVGAGVAFLVLMATIVAFCCARSQRSTGGRSGISGRGTEKKARLRLPRRANLKGVVSAKN 550 560 570 580 590 600 580 590 600 610 620 630 pF1KA1 DIRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DIRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTN 610 620 630 640 650 660 640 650 660 670 680 690 pF1KA1 GYYSVNTFKEHHSTPTISLSSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GYYSVNTFKEHHSTPTISLSSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRF 670 680 690 700 710 720 700 710 720 730 740 750 pF1KA1 VLGMGSSSIELCEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLGMGSSSIELCEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSH 730 740 750 760 770 780 760 770 pF1KA1 HSQSSSQNSDPSRPLQRRMQTHV ::::::::::::::::::::::: XP_011 HSQSSSQNSDPSRPLQRRMQTHV 790 800 >>XP_011541328 (OMIM: 607761,612581) PREDICTED: kin of I (809 aa) initn: 5004 init1: 3621 opt: 3621 Z-score: 2625.1 bits: 496.6 E(85289): 1.8e-139 Smith-Waterman score: 4952; 96.8% identity (96.8% similar) in 785 aa overlap (19-778:25-809) 10 20 30 40 50 pF1KA1 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQP :::::::::::::::::::::::::::::::::::: XP_011 MDASLGAGLRCSGIASSPLRMQQNELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KA1 QDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA1 LRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADN 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA1 AKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAI 190 200 210 220 230 240 240 250 260 270 280 290 pF1KA1 PGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA1 SGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIF 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA1 SCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTL 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA1 TVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETIS 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA1 TEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPM 490 500 510 520 530 540 540 550 560 pF1KA1 AVIIGVAVGAGVAFLVLMATIVAFCCARSQR-------------------------NLKG ::::::::::::::::::::::::::::::: :::: XP_011 AVIIGVAVGAGVAFLVLMATIVAFCCARSQRSTGGRSGISGRGTEKKARLRLPRRANLKG 550 560 570 580 590 600 570 580 590 600 610 620 pF1KA1 VVSAKNDIRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVSAKNDIRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQN 610 620 630 640 650 660 630 640 650 660 670 680 pF1KA1 LKDPTNGYYSVNTFKEHHSTPTISLSSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGRLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKDPTNGYYSVNTFKEHHSTPTISLSSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGRLY 670 680 690 700 710 720 690 700 710 720 730 740 pF1KA1 DYGQRFVLGMGSSSIELCEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DYGQRFVLGMGSSSIELCEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKA 730 740 750 760 770 780 750 760 770 pF1KA1 SASSSHHSQSSSQNSDPSRPLQRRMQTHV ::::::::::::::::::::::::::::: XP_011 SASSSHHSQSSSQNSDPSRPLQRRMQTHV 790 800 >>NP_001288026 (OMIM: 607761,612581) kin of IRRE-like pr (766 aa) initn: 3444 init1: 3444 opt: 3446 Z-score: 2499.4 bits: 473.2 E(85289): 1.8e-132 Smith-Waterman score: 5032; 98.5% identity (98.5% similar) in 778 aa overlap (1-778:1-766) 10 20 30 40 50 60 pF1KA1 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV ::::::::::::::::::::::::::::::::::::: ::::::::::: NP_001 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQ------------ESVPMAVIIGV 490 500 510 520 550 560 570 580 590 600 pF1KA1 AVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQ 530 540 550 560 570 580 610 620 630 640 650 660 pF1KA1 LMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPD 590 600 610 620 630 640 670 680 690 700 710 720 pF1KA1 LRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSS 650 660 670 680 690 700 730 740 750 760 770 pF1KA1 SFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV 710 720 730 740 750 760 778 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 22:11:31 2016 done: Wed Nov 2 22:11:33 2016 Total Scan time: 11.210 Total Display time: 0.220 Function used was FASTA [36.3.4 Apr, 2011]