FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1878, 439 aa 1>>>pF1KA1878 439 - 439 aa - 439 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.6889+/-0.000368; mu= -9.6181+/- 0.023 mean_var=374.6722+/-75.497, 0's: 0 Z-trim(124.6): 9 B-trim: 208 in 1/54 Lambda= 0.066260 statistics sampled from 46743 (46752) to 46743 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.812), E-opt: 0.2 (0.548), width: 16 Scan time: 11.410 The best scores are: opt bits E(85289) NP_997460 (OMIM: 601783) microtubule-associated pr ( 439) 3007 300.8 4.6e-81 NP_149052 (OMIM: 601783) microtubule-associated pr ( 813) 3007 301.0 7.4e-81 XP_016873244 (OMIM: 601783) PREDICTED: microtubule ( 829) 2618 263.8 1.2e-69 XP_006718619 (OMIM: 601783) PREDICTED: microtubule ( 393) 2594 261.3 3.2e-69 XP_011543341 (OMIM: 601783) PREDICTED: microtubule ( 404) 2594 261.3 3.3e-69 XP_016873246 (OMIM: 601783) PREDICTED: microtubule ( 512) 900 99.5 2.2e-20 XP_016873245 (OMIM: 601783) PREDICTED: microtubule ( 528) 511 62.3 3.5e-09 XP_016873247 (OMIM: 601783) PREDICTED: microtubule ( 500) 413 52.9 2.2e-06 >>NP_997460 (OMIM: 601783) microtubule-associated protei (439 aa) initn: 3007 init1: 3007 opt: 3007 Z-score: 1576.4 bits: 300.8 E(85289): 4.6e-81 Smith-Waterman score: 3007; 99.8% identity (100.0% similar) in 439 aa overlap (1-439:1-439) 10 20 30 40 50 60 pF1KA1 MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 KAGPAWMVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 KAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 RSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTK 370 380 390 400 410 420 430 pF1KA1 PDDKEQSKEMNNKLAEAKE ::::::::::::::::::: NP_997 PDDKEQSKEMNNKLAEAKE 430 >>NP_149052 (OMIM: 601783) microtubule-associated protei (813 aa) initn: 3007 init1: 3007 opt: 3007 Z-score: 1572.7 bits: 301.0 E(85289): 7.4e-81 Smith-Waterman score: 3007; 99.8% identity (100.0% similar) in 439 aa overlap (1-439:1-439) 10 20 30 40 50 60 pF1KA1 MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 KAGPAWMVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 KAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 RSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTK 370 380 390 400 410 420 430 pF1KA1 PDDKEQSKEMNNKLAEAKE ::::::::::::::::::: NP_149 PDDKEQSKEMNNKLAEAKESLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQE 430 440 450 460 470 480 >>XP_016873244 (OMIM: 601783) PREDICTED: microtubule-ass (829 aa) initn: 2993 init1: 2594 opt: 2618 Z-score: 1371.6 bits: 263.8 E(85289): 1.2e-69 Smith-Waterman score: 2965; 96.3% identity (96.5% similar) in 455 aa overlap (1-439:1-455) 10 20 30 40 50 60 pF1KA1 MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 KAGPAWMVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI 310 320 330 340 350 360 370 380 390 400 pF1KA1 RSLYSEPFKEPPK----------------VEKPSVQSSKPKKTSASHKPTRKAKDKQAVS ::::::::::::: ::::::::::::::::::::::::::::::: XP_016 RSLYSEPFKEPPKSCTSVEFPIWPRTSLWVEKPSVQSSKPKKTSASHKPTRKAKDKQAVS 370 380 390 400 410 420 410 420 430 pF1KA1 GQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEAKE ::::::::::::::::::::::::::::::::::: XP_016 GQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEAKESLAQPVSDSSKTQGPVATEPDKDQG 430 440 450 460 470 480 XP_016 SVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDLGPMIPLPVKDQDHTVPEPLKNESPVISA 490 500 510 520 530 540 >>XP_006718619 (OMIM: 601783) PREDICTED: microtubule-ass (393 aa) initn: 2594 init1: 2594 opt: 2594 Z-score: 1363.7 bits: 261.3 E(85289): 3.2e-69 Smith-Waterman score: 2594; 99.7% identity (100.0% similar) in 373 aa overlap (1-373:1-373) 10 20 30 40 50 60 pF1KA1 MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 KAGPAWMVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTK ::::::::::::: XP_006 RSLYSEPFKEPPKSCTSVEFPIWPRTSLWVRSD 370 380 390 >>XP_011543341 (OMIM: 601783) PREDICTED: microtubule-ass (404 aa) initn: 2594 init1: 2594 opt: 2594 Z-score: 1363.5 bits: 261.3 E(85289): 3.3e-69 Smith-Waterman score: 2594; 99.7% identity (100.0% similar) in 373 aa overlap (1-373:1-373) 10 20 30 40 50 60 pF1KA1 MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 KAGPAWMVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 RSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTK ::::::::::::: XP_011 RSLYSEPFKEPPKSCTSVEFPIWPRTSLWVRSGVTESRCTSVSE 370 380 390 400 >>XP_016873246 (OMIM: 601783) PREDICTED: microtubule-ass (512 aa) initn: 900 init1: 900 opt: 900 Z-score: 486.9 bits: 99.5 E(85289): 2.2e-20 Smith-Waterman score: 900; 100.0% identity (100.0% similar) in 137 aa overlap (303-439:2-138) 280 290 300 310 320 330 pF1KA1 PEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVH :::::::::::::::::::::::::::::: XP_016 MNEFRAWTDIKPVKPIKAKPQYKPPDDKMVH 10 20 30 340 350 360 370 380 390 pF1KA1 ETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHK 40 50 60 70 80 90 400 410 420 430 pF1KA1 PTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEAKE ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEAKESLAQPVSDSSKTQ 100 110 120 130 140 150 XP_016 GPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDLGPMIPLPVKDQDHTVP 160 170 180 190 200 210 >>XP_016873245 (OMIM: 601783) PREDICTED: microtubule-ass (528 aa) initn: 886 init1: 487 opt: 511 Z-score: 285.8 bits: 62.3 E(85289): 3.5e-09 Smith-Waterman score: 858; 89.5% identity (89.5% similar) in 153 aa overlap (303-439:2-154) 280 290 300 310 320 330 pF1KA1 PEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVH :::::::::::::::::::::::::::::: XP_016 MNEFRAWTDIKPVKPIKAKPQYKPPDDKMVH 10 20 30 340 350 360 370 pF1KA1 ETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPK----------------VEK ::::::::::::::::::::::::::::::::::::::::: ::: XP_016 ETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKSCTSVEFPIWPRTSLWVEK 40 50 60 70 80 90 380 390 400 410 420 430 pF1KA1 PSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAE 100 110 120 130 140 150 pF1KA1 AKE ::: XP_016 AKESLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDL 160 170 180 190 200 210 >>XP_016873247 (OMIM: 601783) PREDICTED: microtubule-ass (500 aa) initn: 688 init1: 413 opt: 413 Z-score: 235.5 bits: 52.9 E(85289): 2.2e-06 Smith-Waterman score: 660; 87.3% identity (87.3% similar) in 126 aa overlap (330-439:1-126) 300 310 320 330 340 350 pF1KA1 SYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRR :::::::::::::::::::::::::::::: XP_016 MVHETSYSAQFKGEASKPTTADNKVIDRRR 10 20 30 360 370 380 390 400 pF1KA1 IRSLYSEPFKEPPK----------------VEKPSVQSSKPKKTSASHKPTRKAKDKQAV :::::::::::::: :::::::::::::::::::::::::::::: XP_016 IRSLYSEPFKEPPKSCTSVEFPIWPRTSLWVEKPSVQSSKPKKTSASHKPTRKAKDKQAV 40 50 60 70 80 90 410 420 430 pF1KA1 SGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEAKE :::::::::::::::::::::::::::::::::::: XP_016 SGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEAKESLAQPVSDSSKTQGPVATEPDKDQ 100 110 120 130 140 150 XP_016 GSVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDLGPMIPLPVKDQDHTVPEPLKNESPVIS 160 170 180 190 200 210 439 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 06:57:17 2016 done: Sat Nov 5 06:57:19 2016 Total Scan time: 11.410 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]