FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1901, 1258 aa 1>>>pF1KA1901 1258 - 1258 aa - 1258 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.2348+/-0.000677; mu= -3.6292+/- 0.041 mean_var=626.9939+/-135.540, 0's: 0 Z-trim(116.5): 1993 B-trim: 0 in 0/56 Lambda= 0.051220 statistics sampled from 25238 (27668) to 25238 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.644), E-opt: 0.2 (0.324), width: 16 Scan time: 15.070 The best scores are: opt bits E(85289) NP_036356 (OMIM: 263520,604588) serine/threonine-p (1258) 8239 626.2 4.2e-178 XP_011530305 (OMIM: 263520,604588) PREDICTED: seri (1258) 8239 626.2 4.2e-178 XP_016863740 (OMIM: 263520,604588) PREDICTED: seri (1051) 6864 524.5 1.5e-147 XP_016863741 (OMIM: 263520,604588) PREDICTED: seri (1051) 6864 524.5 1.5e-147 NP_001186328 (OMIM: 263520,604588) serine/threonin (1189) 4788 371.2 2.4e-101 XP_011530306 (OMIM: 263520,604588) PREDICTED: seri (1214) 4788 371.2 2.4e-101 NP_001186329 (OMIM: 263520,604588) serine/threonin (1214) 4788 371.2 2.4e-101 NP_001186327 (OMIM: 263520,604588) serine/threonin (1242) 4624 359.1 1.1e-97 XP_016863743 (OMIM: 263520,604588) PREDICTED: seri ( 834) 4583 355.8 7e-97 XP_016863742 (OMIM: 263520,604588) PREDICTED: seri ( 902) 4583 355.9 7.3e-97 XP_016863739 (OMIM: 263520,604588) PREDICTED: seri (1079) 4583 356.0 8.1e-97 XP_016863738 (OMIM: 263520,604588) PREDICTED: seri (1079) 4583 356.0 8.1e-97 NP_001186326 (OMIM: 263520,604588) serine/threonin (1286) 4583 356.1 9e-97 XP_006714291 (OMIM: 263520,604588) PREDICTED: seri (1227) 3699 290.7 4e-77 XP_011530307 (OMIM: 263520,604588) PREDICTED: seri ( 715) 3684 289.3 6.4e-77 XP_011533370 (OMIM: 616731) PREDICTED: serine/thre ( 483) 1266 110.4 3.1e-23 XP_006719871 (OMIM: 616731) PREDICTED: serine/thre ( 598) 1266 110.5 3.5e-23 XP_011533368 (OMIM: 616731) PREDICTED: serine/thre ( 697) 1266 110.6 3.8e-23 NP_954983 (OMIM: 616731) serine/threonine-protein ( 708) 1266 110.6 3.9e-23 XP_016876045 (OMIM: 616731) PREDICTED: serine/thre ( 737) 1266 110.6 4e-23 XP_016876044 (OMIM: 616731) PREDICTED: serine/thre ( 755) 1266 110.6 4e-23 XP_016876046 (OMIM: 616731) PREDICTED: serine/thre ( 780) 1266 110.7 4.1e-23 NP_001139571 (OMIM: 604044) serine/threonine-prote ( 489) 1094 97.7 2.1e-19 NP_689933 (OMIM: 604044) serine/threonine-protein ( 506) 1088 97.2 2.9e-19 NP_002489 (OMIM: 604044) serine/threonine-protein ( 506) 1088 97.2 2.9e-19 XP_011532342 (OMIM: 601959) PREDICTED: serine/thre ( 671) 979 89.4 9.1e-17 XP_006713373 (OMIM: 601959) PREDICTED: serine/thre ( 795) 979 89.5 1e-16 XP_016862575 (OMIM: 601959) PREDICTED: serine/thre ( 824) 979 89.5 1e-16 NP_003148 (OMIM: 601959) serine/threonine-protein ( 841) 979 89.5 1e-16 XP_011532341 (OMIM: 601959) PREDICTED: serine/thre ( 842) 979 89.5 1e-16 XP_016862574 (OMIM: 601959) PREDICTED: serine/thre ( 870) 979 89.5 1.1e-16 NP_835464 (OMIM: 609799,613824,615415) serine/thre ( 692) 808 76.7 5.9e-13 XP_016879988 (OMIM: 609799,613824,615415) PREDICTE ( 705) 808 76.7 6e-13 XP_016879990 (OMIM: 609799,613824,615415) PREDICTE ( 484) 749 72.2 9.9e-12 NP_149107 (OMIM: 609798,614262,617022,617025) seri ( 979) 754 73.0 1.1e-11 NP_001316166 (OMIM: 609798,614262,617022,617025) s ( 991) 754 73.0 1.2e-11 XP_011522942 (OMIM: 609799,613824,615415) PREDICTE ( 716) 749 72.4 1.2e-11 XP_011522940 (OMIM: 609799,613824,615415) PREDICTE ( 729) 749 72.4 1.2e-11 NP_665917 (OMIM: 609779) serine/threonine-protein ( 470) 741 71.5 1.5e-11 NP_001308152 (OMIM: 609779) serine/threonine-prote ( 482) 741 71.6 1.5e-11 XP_016862702 (OMIM: 609779) PREDICTED: serine/thre ( 599) 741 71.7 1.7e-11 NP_001139475 (OMIM: 609779) serine/threonine-prote ( 599) 741 71.7 1.7e-11 XP_016862703 (OMIM: 609779) PREDICTED: serine/thre ( 599) 741 71.7 1.7e-11 XP_011511469 (OMIM: 609779) PREDICTED: serine/thre ( 645) 741 71.7 1.8e-11 NP_001308149 (OMIM: 609779) serine/threonine-prote ( 645) 741 71.7 1.8e-11 NP_079076 (OMIM: 609779) serine/threonine-protein ( 645) 741 71.7 1.8e-11 XP_016862704 (OMIM: 609779) PREDICTED: serine/thre ( 563) 734 71.1 2.3e-11 XP_016862705 (OMIM: 609779) PREDICTED: serine/thre ( 563) 734 71.1 2.3e-11 XP_016862701 (OMIM: 609779) PREDICTED: serine/thre ( 609) 734 71.2 2.4e-11 XP_016879989 (OMIM: 609799,613824,615415) PREDICTE ( 666) 719 70.1 5.5e-11 >>NP_036356 (OMIM: 263520,604588) serine/threonine-prote (1258 aa) initn: 8239 init1: 8239 opt: 8239 Z-score: 3318.6 bits: 626.2 E(85289): 4.2e-178 Smith-Waterman score: 8239; 100.0% identity (100.0% similar) in 1258 aa overlap (1-1258:1-1258) 10 20 30 40 50 60 pF1KA1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 SVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 SVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 EAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 EAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 VKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPERGIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 VKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPERGIL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 PGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 PGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 KREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 KREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADM 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 RRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 RRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 TGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 TGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 KAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 KAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 TTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 TTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEG 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 EKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 EKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLET 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 EILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 EILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSD 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 IHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 IHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSH 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 LPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 LPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEID 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA1 EIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 EIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEP 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA1 TANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 TANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFE 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KA1 KFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 KFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE 1210 1220 1230 1240 1250 >>XP_011530305 (OMIM: 263520,604588) PREDICTED: serine/t (1258 aa) initn: 8239 init1: 8239 opt: 8239 Z-score: 3318.6 bits: 626.2 E(85289): 4.2e-178 Smith-Waterman score: 8239; 100.0% identity (100.0% similar) in 1258 aa overlap (1-1258:1-1258) 10 20 30 40 50 60 pF1KA1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 SVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 EAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 VKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPERGIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPERGIL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 PGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 KREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADM 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 RRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 TGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 KAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 TTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEG 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 EKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLET 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 EILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSD 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 IHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSH 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 LPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEID 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA1 EIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEP 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA1 TANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFE 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KA1 KFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE 1210 1220 1230 1240 1250 >>XP_016863740 (OMIM: 263520,604588) PREDICTED: serine/t (1051 aa) initn: 6864 init1: 6864 opt: 6864 Z-score: 2770.2 bits: 524.5 E(85289): 1.5e-147 Smith-Waterman score: 6864; 100.0% identity (100.0% similar) in 1051 aa overlap (208-1258:1-1051) 180 190 200 210 220 230 pF1KA1 KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQ :::::::::::::::::::::::::::::: XP_016 MKNLVLKIISGSFPPVSLHYSYDLRSLVSQ 10 20 30 240 250 260 270 280 290 pF1KA1 LFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQ 40 50 60 70 80 90 300 310 320 330 340 350 pF1KA1 NSISVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NSISVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRK 100 110 120 130 140 150 360 370 380 390 400 410 pF1KA1 ISEEAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISEEAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGG 160 170 180 190 200 210 420 430 440 450 460 470 pF1KA1 SGEVKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGEVKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPER 220 230 240 250 260 270 480 490 500 510 520 530 pF1KA1 GILPGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GILPGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEF 280 290 300 310 320 330 540 550 560 570 580 590 pF1KA1 LQRKREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQRKREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEE 340 350 360 370 380 390 600 610 620 630 640 650 pF1KA1 ADMRRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADMRRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLG 400 410 420 430 440 450 660 670 680 690 700 710 pF1KA1 QHETGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QHETGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLN 460 470 480 490 500 510 720 730 740 750 760 770 pF1KA1 ENLKAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENLKAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDT 520 530 540 550 560 570 780 790 800 810 820 830 pF1KA1 SFSTTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFSTTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEIS 580 590 600 610 620 630 840 850 860 870 880 890 pF1KA1 PEGEKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEGEKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDD 640 650 660 670 680 690 900 910 920 930 940 950 pF1KA1 LETEILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LETEILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQ 700 710 720 730 740 750 960 970 980 990 1000 1010 pF1KA1 LSDIHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSDIHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRS 760 770 780 790 800 810 1020 1030 1040 1050 1060 1070 pF1KA1 HSHLPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSHLPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNL 820 830 840 850 860 870 1080 1090 1100 1110 1120 1130 pF1KA1 EIDEIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EIDEIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSD 880 890 900 910 920 930 1140 1150 1160 1170 1180 1190 pF1KA1 VEPTANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEPTANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEM 940 950 960 970 980 990 1200 1210 1220 1230 1240 1250 pF1KA1 GFEKFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFEKFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDND 1000 1010 1020 1030 1040 1050 pF1KA1 E : XP_016 E >>XP_016863741 (OMIM: 263520,604588) PREDICTED: serine/t (1051 aa) initn: 6864 init1: 6864 opt: 6864 Z-score: 2770.2 bits: 524.5 E(85289): 1.5e-147 Smith-Waterman score: 6864; 100.0% identity (100.0% similar) in 1051 aa overlap (208-1258:1-1051) 180 190 200 210 220 230 pF1KA1 KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQ :::::::::::::::::::::::::::::: XP_016 MKNLVLKIISGSFPPVSLHYSYDLRSLVSQ 10 20 30 240 250 260 270 280 290 pF1KA1 LFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQ 40 50 60 70 80 90 300 310 320 330 340 350 pF1KA1 NSISVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NSISVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRK 100 110 120 130 140 150 360 370 380 390 400 410 pF1KA1 ISEEAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISEEAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGG 160 170 180 190 200 210 420 430 440 450 460 470 pF1KA1 SGEVKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGEVKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPER 220 230 240 250 260 270 480 490 500 510 520 530 pF1KA1 GILPGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GILPGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEF 280 290 300 310 320 330 540 550 560 570 580 590 pF1KA1 LQRKREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQRKREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEE 340 350 360 370 380 390 600 610 620 630 640 650 pF1KA1 ADMRRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADMRRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLG 400 410 420 430 440 450 660 670 680 690 700 710 pF1KA1 QHETGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QHETGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLN 460 470 480 490 500 510 720 730 740 750 760 770 pF1KA1 ENLKAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENLKAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDT 520 530 540 550 560 570 780 790 800 810 820 830 pF1KA1 SFSTTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFSTTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEIS 580 590 600 610 620 630 840 850 860 870 880 890 pF1KA1 PEGEKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEGEKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDD 640 650 660 670 680 690 900 910 920 930 940 950 pF1KA1 LETEILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LETEILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQ 700 710 720 730 740 750 960 970 980 990 1000 1010 pF1KA1 LSDIHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSDIHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRS 760 770 780 790 800 810 1020 1030 1040 1050 1060 1070 pF1KA1 HSHLPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSHLPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNL 820 830 840 850 860 870 1080 1090 1100 1110 1120 1130 pF1KA1 EIDEIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EIDEIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSD 880 890 900 910 920 930 1140 1150 1160 1170 1180 1190 pF1KA1 VEPTANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEPTANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEM 940 950 960 970 980 990 1200 1210 1220 1230 1240 1250 pF1KA1 GFEKFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFEKFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDND 1000 1010 1020 1030 1040 1050 pF1KA1 E : XP_016 E >>NP_001186328 (OMIM: 263520,604588) serine/threonine-pr (1189 aa) initn: 7378 init1: 4786 opt: 4788 Z-score: 1940.6 bits: 371.2 E(85289): 2.4e-101 Smith-Waterman score: 7610; 94.5% identity (94.5% similar) in 1258 aa overlap (1-1258:1-1189) 10 20 30 40 50 60 pF1KA1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 SVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 EAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGE ::::::::::::::::::::::::::::::::::::: NP_001 EAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKER----------------------- 370 380 390 430 440 450 460 470 480 pF1KA1 VKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPERGIL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 --APFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPER--- 400 410 420 430 440 450 490 500 510 520 530 540 pF1KA1 PGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQR ::::::::::::::::::: NP_001 -----------------------------------------QKGQLAVERAKQVEEFLQR 460 470 550 560 570 580 590 600 pF1KA1 KREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADM 480 490 500 510 520 530 610 620 630 640 650 660 pF1KA1 RRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHE 540 550 560 570 580 590 670 680 690 700 710 720 pF1KA1 TGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENL 600 610 620 630 640 650 730 740 750 760 770 780 pF1KA1 KAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFS 660 670 680 690 700 710 790 800 810 820 830 840 pF1KA1 TTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEG 720 730 740 750 760 770 850 860 870 880 890 900 pF1KA1 EKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLET 780 790 800 810 820 830 910 920 930 940 950 960 pF1KA1 EILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSD 840 850 860 870 880 890 970 980 990 1000 1010 1020 pF1KA1 IHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSH 900 910 920 930 940 950 1030 1040 1050 1060 1070 1080 pF1KA1 LPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEID 960 970 980 990 1000 1010 1090 1100 1110 1120 1130 1140 pF1KA1 EIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEP 1020 1030 1040 1050 1060 1070 1150 1160 1170 1180 1190 1200 pF1KA1 TANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFE 1080 1090 1100 1110 1120 1130 1210 1220 1230 1240 1250 pF1KA1 KFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE 1140 1150 1160 1170 1180 >>XP_011530306 (OMIM: 263520,604588) PREDICTED: serine/t (1214 aa) initn: 4786 init1: 4786 opt: 4788 Z-score: 1940.5 bits: 371.2 E(85289): 2.4e-101 Smith-Waterman score: 7835; 96.5% identity (96.5% similar) in 1258 aa overlap (1-1258:1-1214) 10 20 30 40 50 60 pF1KA1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 SVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 EAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 VKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPERGIL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPER--- 430 440 450 460 470 490 500 510 520 530 540 pF1KA1 PGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQR ::::::::::::::::::: XP_011 -----------------------------------------QKGQLAVERAKQVEEFLQR 480 490 550 560 570 580 590 600 pF1KA1 KREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADM 500 510 520 530 540 550 610 620 630 640 650 660 pF1KA1 RRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHE 560 570 580 590 600 610 670 680 690 700 710 720 pF1KA1 TGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENL 620 630 640 650 660 670 730 740 750 760 770 780 pF1KA1 KAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFS 680 690 700 710 720 730 790 800 810 820 830 840 pF1KA1 TTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEG 740 750 760 770 780 790 850 860 870 880 890 900 pF1KA1 EKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLET 800 810 820 830 840 850 910 920 930 940 950 960 pF1KA1 EILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSD 860 870 880 890 900 910 970 980 990 1000 1010 1020 pF1KA1 IHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSH 920 930 940 950 960 970 1030 1040 1050 1060 1070 1080 pF1KA1 LPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEID 980 990 1000 1010 1020 1030 1090 1100 1110 1120 1130 1140 pF1KA1 EIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEP 1040 1050 1060 1070 1080 1090 1150 1160 1170 1180 1190 1200 pF1KA1 TANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFE 1100 1110 1120 1130 1140 1150 1210 1220 1230 1240 1250 pF1KA1 KFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE 1160 1170 1180 1190 1200 1210 >>NP_001186329 (OMIM: 263520,604588) serine/threonine-pr (1214 aa) initn: 4786 init1: 4786 opt: 4788 Z-score: 1940.5 bits: 371.2 E(85289): 2.4e-101 Smith-Waterman score: 7835; 96.5% identity (96.5% similar) in 1258 aa overlap (1-1258:1-1214) 10 20 30 40 50 60 pF1KA1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 SVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 EAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 VKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPERGIL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPER--- 430 440 450 460 470 490 500 510 520 530 540 pF1KA1 PGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQR ::::::::::::::::::: NP_001 -----------------------------------------QKGQLAVERAKQVEEFLQR 480 490 550 560 570 580 590 600 pF1KA1 KREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADM 500 510 520 530 540 550 610 620 630 640 650 660 pF1KA1 RRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHE 560 570 580 590 600 610 670 680 690 700 710 720 pF1KA1 TGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENL 620 630 640 650 660 670 730 740 750 760 770 780 pF1KA1 KAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFS 680 690 700 710 720 730 790 800 810 820 830 840 pF1KA1 TTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEG 740 750 760 770 780 790 850 860 870 880 890 900 pF1KA1 EKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLET 800 810 820 830 840 850 910 920 930 940 950 960 pF1KA1 EILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSD 860 870 880 890 900 910 970 980 990 1000 1010 1020 pF1KA1 IHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSH 920 930 940 950 960 970 1030 1040 1050 1060 1070 1080 pF1KA1 LPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEID 980 990 1000 1010 1020 1030 1090 1100 1110 1120 1130 1140 pF1KA1 EIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEP 1040 1050 1060 1070 1080 1090 1150 1160 1170 1180 1190 1200 pF1KA1 TANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFE 1100 1110 1120 1130 1140 1150 1210 1220 1230 1240 1250 pF1KA1 KFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE 1160 1170 1180 1190 1200 1210 >>NP_001186327 (OMIM: 263520,604588) serine/threonine-pr (1242 aa) initn: 7702 init1: 4562 opt: 4624 Z-score: 1874.9 bits: 359.1 E(85289): 1.1e-97 Smith-Waterman score: 7769; 94.4% identity (94.4% similar) in 1286 aa overlap (1-1258:1-1242) 10 20 30 40 50 60 pF1KA1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 SVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 EAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 VKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPERGIL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPER--- 430 440 450 460 470 490 500 510 520 530 540 pF1KA1 PGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQR ::::::::::::::::::: NP_001 -----------------------------------------QKGQLAVERAKQVEEFLQR 480 490 550 560 570 pF1KA1 KREAMQNKARAEGHM----------------------------VYLARLRQIRLQNFNER ::::::::::::::: ::::::::::::::::: NP_001 KREAMQNKARAEGHMGILQNLAAMYGGRPSSSRGGKPRNKEEEVYLARLRQIRLQNFNER 500 510 520 530 540 550 580 590 600 610 620 630 pF1KA1 QQIKAKLRGEKKEANHSEGQEGSEEADMRRKKIESLKAHANARAAVLKEQLERKRKEAYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQIKAKLRGEKKEANHSEGQEGSEEADMRRKKIESLKAHANARAAVLKEQLERKRKEAYE 560 570 580 590 600 610 640 650 660 670 680 690 pF1KA1 REKKVWEEHLVAKGVKSSDVSPPLGQHETGGSPSKQQMRSVISVTSALKEVGVDSSLTDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REKKVWEEHLVAKGVKSSDVSPPLGQHETGGSPSKQQMRSVISVTSALKEVGVDSSLTDT 620 630 640 650 660 670 700 710 720 730 740 750 pF1KA1 RETSEEMQKTNNAISSKREILRRLNENLKAQEDEKGKQNLSDTFEINVHEDAKEHEKEKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RETSEEMQKTNNAISSKREILRRLNENLKAQEDEKGKQNLSDTFEINVHEDAKEHEKEKS 680 690 700 710 720 730 760 770 780 790 800 810 pF1KA1 VSSDRKKWEAGGQLVIPLDELTLDTSFSTTERHTVGEVIKLGPNGSPRRAWGKSPTDSVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSSDRKKWEAGGQLVIPLDELTLDTSFSTTERHTVGEVIKLGPNGSPRRAWGKSPTDSVL 740 750 760 770 780 790 820 830 840 850 860 870 pF1KA1 KILGEAELQLQTELLENTTIRSEISPEGEKYKPLITGEKKVQCISHEINPSAIVDSPVET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KILGEAELQLQTELLENTTIRSEISPEGEKYKPLITGEKKVQCISHEINPSAIVDSPVET 800 810 820 830 840 850 880 890 900 910 920 930 pF1KA1 KSPEFSEASPQMSLKLEGNLEEPDDLETEILQEPSGTNKDESLPCTITDVWISEEKETKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSPEFSEASPQMSLKLEGNLEEPDDLETEILQEPSGTNKDESLPCTITDVWISEEKETKE 860 870 880 890 900 910 940 950 960 970 980 990 pF1KA1 TQSADRITIQENEVSEDGVSSTVDQLSDIHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQSADRITIQENEVSEDGVSSTVDQLSDIHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVH 920 930 940 950 960 970 1000 1010 1020 1030 1040 1050 pF1KA1 SEHLNLVPQVQSVQCSPEESFAFRSHSHLPPKNKNKNSLLIGLSTGLFDANNPKMLRTCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEHLNLVPQVQSVQCSPEESFAFRSHSHLPPKNKNKNSLLIGLSTGLFDANNPKMLRTCS 980 990 1000 1010 1020 1030 1060 1070 1080 1090 1100 1110 pF1KA1 LPDLSKLFRTLMDVPTVGDVRQDNLEIDEIEDENIKEGPSDSEDIVFEETDTDLQELQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPDLSKLFRTLMDVPTVGDVRQDNLEIDEIEDENIKEGPSDSEDIVFEETDTDLQELQAS 1040 1050 1060 1070 1080 1090 1120 1130 1140 1150 1160 1170 pF1KA1 MEQLLREQPGEEYSEEEESVLKNSDVEPTANGTDVADEDDNPSSESALNEEWHSDNSDGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEQLLREQPGEEYSEEEESVLKNSDVEPTANGTDVADEDDNPSSESALNEEWHSDNSDGE 1100 1110 1120 1130 1140 1150 1180 1190 1200 1210 1220 1230 pF1KA1 IASECECDSVFNHLEELRLHLEQEMGFEKFFEVYEKIKAIHEDEDENIEICSKIVQNILG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IASECECDSVFNHLEELRLHLEQEMGFEKFFEVYEKIKAIHEDEDENIEICSKIVQNILG 1160 1170 1180 1190 1200 1210 1240 1250 pF1KA1 NEHQHLYAKILHLVMADGAYQEDNDE :::::::::::::::::::::::::: NP_001 NEHQHLYAKILHLVMADGAYQEDNDE 1220 1230 1240 >>XP_016863743 (OMIM: 263520,604588) PREDICTED: serine/t (834 aa) initn: 4562 init1: 4562 opt: 4583 Z-score: 1860.3 bits: 355.8 E(85289): 7e-97 Smith-Waterman score: 5195; 96.6% identity (96.6% similar) in 834 aa overlap (453-1258:1-834) 430 440 450 460 470 480 pF1KA1 APFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPERGILPG :::::::::::::::::::::::::::::: XP_016 MQQQRAEDNEAKWKREIYGRGLPERGILPG 10 20 30 490 500 510 520 530 540 pF1KA1 VRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQRKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQRKR 40 50 60 70 80 90 550 560 570 pF1KA1 EAMQNKARAEGHM----------------------------VYLARLRQIRLQNFNERQQ ::::::::::::: ::::::::::::::::::: XP_016 EAMQNKARAEGHMGILQNLAAMYGGRPSSSRGGKPRNKEEEVYLARLRQIRLQNFNERQQ 100 110 120 130 140 150 580 590 600 610 620 630 pF1KA1 IKAKLRGEKKEANHSEGQEGSEEADMRRKKIESLKAHANARAAVLKEQLERKRKEAYERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IKAKLRGEKKEANHSEGQEGSEEADMRRKKIESLKAHANARAAVLKEQLERKRKEAYERE 160 170 180 190 200 210 640 650 660 670 680 690 pF1KA1 KKVWEEHLVAKGVKSSDVSPPLGQHETGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKVWEEHLVAKGVKSSDVSPPLGQHETGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRE 220 230 240 250 260 270 700 710 720 730 740 750 pF1KA1 TSEEMQKTNNAISSKREILRRLNENLKAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSEEMQKTNNAISSKREILRRLNENLKAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVS 280 290 300 310 320 330 760 770 780 790 800 810 pF1KA1 SDRKKWEAGGQLVIPLDELTLDTSFSTTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDRKKWEAGGQLVIPLDELTLDTSFSTTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKI 340 350 360 370 380 390 820 830 840 850 860 870 pF1KA1 LGEAELQLQTELLENTTIRSEISPEGEKYKPLITGEKKVQCISHEINPSAIVDSPVETKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGEAELQLQTELLENTTIRSEISPEGEKYKPLITGEKKVQCISHEINPSAIVDSPVETKS 400 410 420 430 440 450 880 890 900 910 920 930 pF1KA1 PEFSEASPQMSLKLEGNLEEPDDLETEILQEPSGTNKDESLPCTITDVWISEEKETKETQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEFSEASPQMSLKLEGNLEEPDDLETEILQEPSGTNKDESLPCTITDVWISEEKETKETQ 460 470 480 490 500 510 940 950 960 970 980 990 pF1KA1 SADRITIQENEVSEDGVSSTVDQLSDIHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SADRITIQENEVSEDGVSSTVDQLSDIHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSE 520 530 540 550 560 570 1000 1010 1020 1030 1040 1050 pF1KA1 HLNLVPQVQSVQCSPEESFAFRSHSHLPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HLNLVPQVQSVQCSPEESFAFRSHSHLPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLP 580 590 600 610 620 630 1060 1070 1080 1090 1100 1110 pF1KA1 DLSKLFRTLMDVPTVGDVRQDNLEIDEIEDENIKEGPSDSEDIVFEETDTDLQELQASME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLSKLFRTLMDVPTVGDVRQDNLEIDEIEDENIKEGPSDSEDIVFEETDTDLQELQASME 640 650 660 670 680 690 1120 1130 1140 1150 1160 1170 pF1KA1 QLLREQPGEEYSEEEESVLKNSDVEPTANGTDVADEDDNPSSESALNEEWHSDNSDGEIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLLREQPGEEYSEEEESVLKNSDVEPTANGTDVADEDDNPSSESALNEEWHSDNSDGEIA 700 710 720 730 740 750 1180 1190 1200 1210 1220 1230 pF1KA1 SECECDSVFNHLEELRLHLEQEMGFEKFFEVYEKIKAIHEDEDENIEICSKIVQNILGNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SECECDSVFNHLEELRLHLEQEMGFEKFFEVYEKIKAIHEDEDENIEICSKIVQNILGNE 760 770 780 790 800 810 1240 1250 pF1KA1 HQHLYAKILHLVMADGAYQEDNDE :::::::::::::::::::::::: XP_016 HQHLYAKILHLVMADGAYQEDNDE 820 830 >>XP_016863742 (OMIM: 263520,604588) PREDICTED: serine/t (902 aa) initn: 4562 init1: 4562 opt: 4583 Z-score: 1860.0 bits: 355.9 E(85289): 7.3e-97 Smith-Waterman score: 5650; 96.9% identity (96.9% similar) in 902 aa overlap (385-1258:1-902) 360 370 380 390 400 410 pF1KA1 RRKISEEAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLS :::::::::::::::::::::::::::::: XP_016 MKAEQMKRQEKERLERINRAREQGWRNVLS 10 20 30 420 430 440 450 460 470 pF1KA1 AGGSGEVKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGGSGEVKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGL 40 50 60 70 80 90 480 490 500 510 520 530 pF1KA1 PERGILPGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PERGILPGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQV 100 110 120 130 140 150 540 550 560 pF1KA1 EEFLQRKREAMQNKARAEGHM----------------------------VYLARLRQIRL ::::::::::::::::::::: ::::::::::: XP_016 EEFLQRKREAMQNKARAEGHMGILQNLAAMYGGRPSSSRGGKPRNKEEEVYLARLRQIRL 160 170 180 190 200 210 570 580 590 600 610 620 pF1KA1 QNFNERQQIKAKLRGEKKEANHSEGQEGSEEADMRRKKIESLKAHANARAAVLKEQLERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QNFNERQQIKAKLRGEKKEANHSEGQEGSEEADMRRKKIESLKAHANARAAVLKEQLERK 220 230 240 250 260 270 630 640 650 660 670 680 pF1KA1 RKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHETGGSPSKQQMRSVISVTSALKEVGVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHETGGSPSKQQMRSVISVTSALKEVGVD 280 290 300 310 320 330 690 700 710 720 730 740 pF1KA1 SSLTDTRETSEEMQKTNNAISSKREILRRLNENLKAQEDEKGKQNLSDTFEINVHEDAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSLTDTRETSEEMQKTNNAISSKREILRRLNENLKAQEDEKGKQNLSDTFEINVHEDAKE 340 350 360 370 380 390 750 760 770 780 790 800 pF1KA1 HEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFSTTERHTVGEVIKLGPNGSPRRAWGKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFSTTERHTVGEVIKLGPNGSPRRAWGKS 400 410 420 430 440 450 810 820 830 840 850 860 pF1KA1 PTDSVLKILGEAELQLQTELLENTTIRSEISPEGEKYKPLITGEKKVQCISHEINPSAIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PTDSVLKILGEAELQLQTELLENTTIRSEISPEGEKYKPLITGEKKVQCISHEINPSAIV 460 470 480 490 500 510 870 880 890 900 910 920 pF1KA1 DSPVETKSPEFSEASPQMSLKLEGNLEEPDDLETEILQEPSGTNKDESLPCTITDVWISE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSPVETKSPEFSEASPQMSLKLEGNLEEPDDLETEILQEPSGTNKDESLPCTITDVWISE 520 530 540 550 560 570 930 940 950 960 970 980 pF1KA1 EKETKETQSADRITIQENEVSEDGVSSTVDQLSDIHIEPGTNDSQHSKCDVDKSVQPEPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKETKETQSADRITIQENEVSEDGVSSTVDQLSDIHIEPGTNDSQHSKCDVDKSVQPEPF 580 590 600 610 620 630 990 1000 1010 1020 1030 1040 pF1KA1 FHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSHLPPKNKNKNSLLIGLSTGLFDANNPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSHLPPKNKNKNSLLIGLSTGLFDANNPK 640 650 660 670 680 690 1050 1060 1070 1080 1090 1100 pF1KA1 MLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEIDEIEDENIKEGPSDSEDIVFEETDTDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEIDEIEDENIKEGPSDSEDIVFEETDTDL 700 710 720 730 740 750 1110 1120 1130 1140 1150 1160 pF1KA1 QELQASMEQLLREQPGEEYSEEEESVLKNSDVEPTANGTDVADEDDNPSSESALNEEWHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QELQASMEQLLREQPGEEYSEEEESVLKNSDVEPTANGTDVADEDDNPSSESALNEEWHS 760 770 780 790 800 810 1170 1180 1190 1200 1210 1220 pF1KA1 DNSDGEIASECECDSVFNHLEELRLHLEQEMGFEKFFEVYEKIKAIHEDEDENIEICSKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DNSDGEIASECECDSVFNHLEELRLHLEQEMGFEKFFEVYEKIKAIHEDEDENIEICSKI 820 830 840 850 860 870 1230 1240 1250 pF1KA1 VQNILGNEHQHLYAKILHLVMADGAYQEDNDE :::::::::::::::::::::::::::::::: XP_016 VQNILGNEHQHLYAKILHLVMADGAYQEDNDE 880 890 900 1258 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 11:24:14 2016 done: Thu Nov 3 11:24:16 2016 Total Scan time: 15.070 Total Display time: 0.580 Function used was FASTA [36.3.4 Apr, 2011]