FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1995, 979 aa 1>>>pF1KA1995 979 - 979 aa - 979 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.5283+/-0.000568; mu= 2.9488+/- 0.035 mean_var=555.5887+/-126.780, 0's: 0 Z-trim(118.7): 1790 B-trim: 654 in 1/54 Lambda= 0.054412 statistics sampled from 29516 (31999) to 29516 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.692), E-opt: 0.2 (0.375), width: 16 Scan time: 15.310 The best scores are: opt bits E(85289) NP_149107 (OMIM: 609798,614262,617022,617025) seri ( 979) 6620 536.4 2.7e-151 NP_001316167 (OMIM: 609798,614262,617022,617025) s ( 861) 5829 474.2 1.3e-132 NP_001316166 (OMIM: 609798,614262,617022,617025) s ( 991) 3427 285.8 7.8e-76 XP_005268266 (OMIM: 609798,614262,617022,617025) P ( 873) 3210 268.6 9.9e-71 XP_011530307 (OMIM: 263520,604588) PREDICTED: seri ( 715) 754 75.7 9.7e-13 NP_001186328 (OMIM: 263520,604588) serine/threonin (1189) 754 76.1 1.3e-12 NP_001186329 (OMIM: 263520,604588) serine/threonin (1214) 754 76.1 1.3e-12 XP_011530306 (OMIM: 263520,604588) PREDICTED: seri (1214) 754 76.1 1.3e-12 XP_006714291 (OMIM: 263520,604588) PREDICTED: seri (1227) 754 76.1 1.3e-12 NP_001186327 (OMIM: 263520,604588) serine/threonin (1242) 754 76.1 1.3e-12 XP_011530305 (OMIM: 263520,604588) PREDICTED: seri (1258) 754 76.1 1.3e-12 NP_036356 (OMIM: 263520,604588) serine/threonine-p (1258) 754 76.1 1.3e-12 NP_001186326 (OMIM: 263520,604588) serine/threonin (1286) 754 76.1 1.3e-12 NP_835464 (OMIM: 609799,613824,615415) serine/thre ( 692) 717 72.8 7.1e-12 XP_016879988 (OMIM: 609799,613824,615415) PREDICTE ( 705) 716 72.7 7.6e-12 XP_011532342 (OMIM: 601959) PREDICTED: serine/thre ( 671) 712 72.4 9.2e-12 XP_006713373 (OMIM: 601959) PREDICTED: serine/thre ( 795) 712 72.5 1e-11 XP_016862575 (OMIM: 601959) PREDICTED: serine/thre ( 824) 712 72.5 1e-11 NP_003148 (OMIM: 601959) serine/threonine-protein ( 841) 712 72.5 1e-11 XP_011532341 (OMIM: 601959) PREDICTED: serine/thre ( 842) 712 72.5 1e-11 XP_016862574 (OMIM: 601959) PREDICTED: serine/thre ( 870) 712 72.5 1.1e-11 XP_011533370 (OMIM: 616731) PREDICTED: serine/thre ( 483) 698 71.0 1.7e-11 XP_006719871 (OMIM: 616731) PREDICTED: serine/thre ( 598) 698 71.2 1.9e-11 XP_011533368 (OMIM: 616731) PREDICTED: serine/thre ( 697) 698 71.3 2e-11 NP_954983 (OMIM: 616731) serine/threonine-protein ( 708) 698 71.3 2e-11 XP_016876045 (OMIM: 616731) PREDICTED: serine/thre ( 737) 698 71.3 2.1e-11 XP_016876044 (OMIM: 616731) PREDICTED: serine/thre ( 755) 698 71.3 2.1e-11 XP_016876046 (OMIM: 616731) PREDICTED: serine/thre ( 780) 698 71.4 2.1e-11 NP_001139571 (OMIM: 604044) serine/threonine-prote ( 489) 668 68.7 8.6e-11 NP_689933 (OMIM: 604044) serine/threonine-protein ( 506) 668 68.7 8.7e-11 NP_002489 (OMIM: 604044) serine/threonine-protein ( 506) 668 68.7 8.7e-11 XP_016879990 (OMIM: 609799,613824,615415) PREDICTE ( 484) 658 67.9 1.5e-10 XP_011522942 (OMIM: 609799,613824,615415) PREDICTE ( 716) 661 68.4 1.5e-10 XP_011522940 (OMIM: 609799,613824,615415) PREDICTE ( 729) 660 68.3 1.6e-10 XP_016879989 (OMIM: 609799,613824,615415) PREDICTE ( 666) 624 65.5 1.1e-09 NP_598001 (OMIM: 606848) serine/threonine-protein ( 302) 578 61.3 8.9e-09 NP_001159642 (OMIM: 604884) serine/threonine-prote ( 313) 566 60.4 1.7e-08 NP_001159640 (OMIM: 604884) serine/threonine-prote ( 313) 566 60.4 1.7e-08 XP_005251721 (OMIM: 604884) PREDICTED: serine/thre ( 313) 566 60.4 1.7e-08 NP_055212 (OMIM: 604884) serine/threonine-protein ( 313) 566 60.4 1.7e-08 XP_006716999 (OMIM: 604884) PREDICTED: serine/thre ( 313) 566 60.4 1.7e-08 NP_001159639 (OMIM: 604884) serine/threonine-prote ( 331) 566 60.4 1.8e-08 NP_001159641 (OMIM: 604884) serine/threonine-prote ( 338) 566 60.4 1.8e-08 XP_016869706 (OMIM: 604884) PREDICTED: serine/thre ( 347) 566 60.4 1.8e-08 NP_001159643 (OMIM: 604884) serine/threonine-prote ( 347) 566 60.4 1.8e-08 NP_001138473 (OMIM: 604884) serine/threonine-prote ( 347) 566 60.4 1.8e-08 NP_665917 (OMIM: 609779) serine/threonine-protein ( 470) 543 58.9 7.5e-08 NP_001308152 (OMIM: 609779) serine/threonine-prote ( 482) 543 58.9 7.6e-08 XP_016862705 (OMIM: 609779) PREDICTED: serine/thre ( 563) 543 59.0 8.3e-08 XP_016862704 (OMIM: 609779) PREDICTED: serine/thre ( 563) 543 59.0 8.3e-08 >>NP_149107 (OMIM: 609798,614262,617022,617025) serine/t (979 aa) initn: 6620 init1: 6620 opt: 6620 Z-score: 2837.1 bits: 536.4 E(85289): 2.7e-151 Smith-Waterman score: 6620; 99.9% identity (100.0% similar) in 979 aa overlap (1-979:1-979) 10 20 30 40 50 60 pF1KA1 MSVLGEYERHCDSINSDFGSESGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 MSVLGEYERHCDSINSDFGSESGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 GAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 NTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 NTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 NIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 NIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 IFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 IFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTAD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 ELLDRPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 ELLDRPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 KLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 KLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 EKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSN ::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 EKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 PVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 PVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 CDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 CDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 TIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 TIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 FTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 FTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 ILIVEKVLNSKTIRSNSSGLSIGTVFQSSSPGGGGGGGGGEEEDSQQESETPDPSGGFRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 ILIVEKVLNSKTIRSNSSGLSIGTVFQSSSPGGGGGGGGGEEEDSQQESETPDPSGGFRG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 TMEADRGMEGLISPTEAMGNSNGASSSCPGWLRKELENAEFIPMPDSPSPLSAAFSESEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 TMEADRGMEGLISPTEAMGNSNGASSSCPGWLRKELENAEFIPMPDSPSPLSAAFSESEK 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 DTLPYEELQGLKVASEAPLEHKPQVEASSPRLNPAVTCAGKGTPLTPPACACSSLQVEVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 DTLPYEELQGLKVASEAPLEHKPQVEASSPRLNPAVTCAGKGTPLTPPACACSSLQVEVE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 RLQGLVLKCLAEQQKLQQENLQIFTQLQKLNKKLEGGQQVGMHSKGTQTAKEEMEMDPKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 RLQGLVLKCLAEQQKLQQENLQIFTQLQKLNKKLEGGQQVGMHSKGTQTAKEEMEMDPKP 910 920 930 940 950 960 970 pF1KA1 DLDSDSWCLLGTDSCRPSL ::::::::::::::::::: NP_149 DLDSDSWCLLGTDSCRPSL 970 >>NP_001316167 (OMIM: 609798,614262,617022,617025) serin (861 aa) initn: 5829 init1: 5829 opt: 5829 Z-score: 2502.0 bits: 474.2 E(85289): 1.3e-132 Smith-Waterman score: 5829; 99.9% identity (100.0% similar) in 861 aa overlap (119-979:1-861) 90 100 110 120 130 140 pF1KA1 SEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLF :::::::::::::::::::::::::::::: NP_001 MDNTTLLIELEYCNGGNLYDKILRQKDKLF 10 20 30 150 160 170 180 190 200 pF1KA1 EEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMA 40 50 60 70 80 90 210 220 230 240 250 260 pF1KA1 ETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIR 100 110 120 130 140 150 270 280 290 300 310 320 pF1KA1 AMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTLLNAPTKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTLLNAPTKR 160 170 180 190 200 210 330 340 350 360 370 380 pF1KA1 PRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEK 220 230 240 250 260 270 390 400 410 420 430 440 pF1KA1 ELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLY ::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::: NP_001 ELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLY 280 290 300 310 320 330 450 460 470 480 490 500 pF1KA1 AFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGE 340 350 360 370 380 390 510 520 530 540 550 560 pF1KA1 YGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQ 400 410 420 430 440 450 570 580 590 600 610 620 pF1KA1 CMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQ 460 470 480 490 500 510 630 640 650 660 670 680 pF1KA1 LGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTE 520 530 540 550 560 570 690 700 710 720 730 740 pF1KA1 RPHGSDICTSWPRPIFGSLHHVPDLSCRGWHTILIVEKVLNSKTIRSNSSGLSIGTVFQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPHGSDICTSWPRPIFGSLHHVPDLSCRGWHTILIVEKVLNSKTIRSNSSGLSIGTVFQS 580 590 600 610 620 630 750 760 770 780 790 800 pF1KA1 SSPGGGGGGGGGEEEDSQQESETPDPSGGFRGTMEADRGMEGLISPTEAMGNSNGASSSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSPGGGGGGGGGEEEDSQQESETPDPSGGFRGTMEADRGMEGLISPTEAMGNSNGASSSC 640 650 660 670 680 690 810 820 830 840 850 860 pF1KA1 PGWLRKELENAEFIPMPDSPSPLSAAFSESEKDTLPYEELQGLKVASEAPLEHKPQVEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGWLRKELENAEFIPMPDSPSPLSAAFSESEKDTLPYEELQGLKVASEAPLEHKPQVEAS 700 710 720 730 740 750 870 880 890 900 910 920 pF1KA1 SPRLNPAVTCAGKGTPLTPPACACSSLQVEVERLQGLVLKCLAEQQKLQQENLQIFTQLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPRLNPAVTCAGKGTPLTPPACACSSLQVEVERLQGLVLKCLAEQQKLQQENLQIFTQLQ 760 770 780 790 800 810 930 940 950 960 970 pF1KA1 KLNKKLEGGQQVGMHSKGTQTAKEEMEMDPKPDLDSDSWCLLGTDSCRPSL ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLNKKLEGGQQVGMHSKGTQTAKEEMEMDPKPDLDSDSWCLLGTDSCRPSL 820 830 840 850 860 >>NP_001316166 (OMIM: 609798,614262,617022,617025) serin (991 aa) initn: 3505 init1: 3427 opt: 3427 Z-score: 1482.4 bits: 285.8 E(85289): 7.8e-76 Smith-Waterman score: 6586; 98.7% identity (98.8% similar) in 991 aa overlap (1-979:1-991) 10 20 30 40 50 60 pF1KA1 MSVLGEYERHCDSINSDFGSESGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSVLGEYERHCDSINSDFGSESGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 NTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 NIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 IFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTAD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 ELLDRPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELLDRPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 KLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 EKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSN ::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSN 430 440 450 460 470 480 490 500 510 520 pF1KA1 PVEQVSCGDNHVVVLTRNKEVYSWGCGEYGR------------LGLDSEEDYYTPQKVDV ::::::::::::::::::::::::::::::: ::::::::::::::::: NP_001 PVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRGSLVSVHFFTGRLGLDSEEDYYTPQKVDV 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA1 PKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSF 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA1 TLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLG 610 620 630 640 650 660 650 660 670 680 690 700 pF1KA1 GKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLH 670 680 690 700 710 720 710 720 730 740 750 760 pF1KA1 HVPDLSCRGWHTILIVEKVLNSKTIRSNSSGLSIGTVFQSSSPGGGGGGGGGEEEDSQQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HVPDLSCRGWHTILIVEKVLNSKTIRSNSSGLSIGTVFQSSSPGGGGGGGGGEEEDSQQE 730 740 750 760 770 780 770 780 790 800 810 820 pF1KA1 SETPDPSGGFRGTMEADRGMEGLISPTEAMGNSNGASSSCPGWLRKELENAEFIPMPDSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SETPDPSGGFRGTMEADRGMEGLISPTEAMGNSNGASSSCPGWLRKELENAEFIPMPDSP 790 800 810 820 830 840 830 840 850 860 870 880 pF1KA1 SPLSAAFSESEKDTLPYEELQGLKVASEAPLEHKPQVEASSPRLNPAVTCAGKGTPLTPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPLSAAFSESEKDTLPYEELQGLKVASEAPLEHKPQVEASSPRLNPAVTCAGKGTPLTPP 850 860 870 880 890 900 890 900 910 920 930 940 pF1KA1 ACACSSLQVEVERLQGLVLKCLAEQQKLQQENLQIFTQLQKLNKKLEGGQQVGMHSKGTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACACSSLQVEVERLQGLVLKCLAEQQKLQQENLQIFTQLQKLNKKLEGGQQVGMHSKGTQ 910 920 930 940 950 960 950 960 970 pF1KA1 TAKEEMEMDPKPDLDSDSWCLLGTDSCRPSL ::::::::::::::::::::::::::::::: NP_001 TAKEEMEMDPKPDLDSDSWCLLGTDSCRPSL 970 980 990 >>XP_005268266 (OMIM: 609798,614262,617022,617025) PREDI (873 aa) initn: 3210 init1: 3210 opt: 3210 Z-score: 1390.9 bits: 268.6 E(85289): 9.9e-71 Smith-Waterman score: 5795; 98.5% identity (98.6% similar) in 873 aa overlap (119-979:1-873) 90 100 110 120 130 140 pF1KA1 SEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLF :::::::::::::::::::::::::::::: XP_005 MDNTTLLIELEYCNGGNLYDKILRQKDKLF 10 20 30 150 160 170 180 190 200 pF1KA1 EEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMA 40 50 60 70 80 90 210 220 230 240 250 260 pF1KA1 ETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIR 100 110 120 130 140 150 270 280 290 300 310 320 pF1KA1 AMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTLLNAPTKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTLLNAPTKR 160 170 180 190 200 210 330 340 350 360 370 380 pF1KA1 PRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEK 220 230 240 250 260 270 390 400 410 420 430 440 pF1KA1 ELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLY ::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::: XP_005 ELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLY 280 290 300 310 320 330 450 460 470 480 490 500 pF1KA1 AFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGE 340 350 360 370 380 390 510 520 530 540 550 pF1KA1 YGR------------LGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLAC ::: ::::::::::::::::::::::::::::::::::::::::::::: XP_005 YGRGSLVSVHFFTGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLAC 400 410 420 430 440 450 560 570 580 590 600 610 pF1KA1 GLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERG 460 470 480 490 500 510 620 630 640 650 660 670 pF1KA1 RLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGN 520 530 540 550 560 570 680 690 700 710 720 730 pF1KA1 GGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHTILIVEKVLNSKTIRSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHTILIVEKVLNSKTIRSN 580 590 600 610 620 630 740 750 760 770 780 790 pF1KA1 SSGLSIGTVFQSSSPGGGGGGGGGEEEDSQQESETPDPSGGFRGTMEADRGMEGLISPTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSGLSIGTVFQSSSPGGGGGGGGGEEEDSQQESETPDPSGGFRGTMEADRGMEGLISPTE 640 650 660 670 680 690 800 810 820 830 840 850 pF1KA1 AMGNSNGASSSCPGWLRKELENAEFIPMPDSPSPLSAAFSESEKDTLPYEELQGLKVASE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AMGNSNGASSSCPGWLRKELENAEFIPMPDSPSPLSAAFSESEKDTLPYEELQGLKVASE 700 710 720 730 740 750 860 870 880 890 900 910 pF1KA1 APLEHKPQVEASSPRLNPAVTCAGKGTPLTPPACACSSLQVEVERLQGLVLKCLAEQQKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 APLEHKPQVEASSPRLNPAVTCAGKGTPLTPPACACSSLQVEVERLQGLVLKCLAEQQKL 760 770 780 790 800 810 920 930 940 950 960 970 pF1KA1 QQENLQIFTQLQKLNKKLEGGQQVGMHSKGTQTAKEEMEMDPKPDLDSDSWCLLGTDSCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQENLQIFTQLQKLNKKLEGGQQVGMHSKGTQTAKEEMEMDPKPDLDSDSWCLLGTDSCR 820 830 840 850 860 870 pF1KA1 PSL ::: XP_005 PSL >>XP_011530307 (OMIM: 263520,604588) PREDICTED: serine/t (715 aa) initn: 695 init1: 695 opt: 754 Z-score: 349.7 bits: 75.7 E(85289): 9.7e-13 Smith-Waterman score: 754; 42.3% identity (75.0% similar) in 260 aa overlap (52-311:4-261) 30 40 50 60 70 80 pF1KA1 SGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGRGAFGEATLYRRTEDDSLVVWK :. .. .:.:.::.: : . ::: : : XP_011 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIK 10 20 30 90 100 110 120 130 140 pF1KA1 EVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKIL :....:.: :::... :...:: ..: ::. : . : .: .: : ..::.::.:. .: XP_011 EINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRIN 40 50 60 70 80 90 150 160 170 180 190 200 pF1KA1 RQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKL :: ::.:.... .. :: :.. .: :::::::. :::::: . ..:::.:.:. : XP_011 AQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVL 100 110 120 130 140 150 210 220 230 240 250 260 pF1KA1 NSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCV :: .:.: .:::::.:::.:.. :: ::::::.:::..:: :::..:.: . :: . XP_011 NSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVL 160 170 180 190 200 210 270 280 290 300 310 320 pF1KA1 KIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTL ::..: .. : .:: .: ..: . . ..:..::... .:.. .. :: XP_011 KIISG--SFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLI 220 230 240 250 260 270 330 340 350 360 370 380 pF1KA1 LNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQKLDVIKSGCSARQVCAGNTHF XP_011 AEEFCLKTFSKFGSQPIPAKRPASGQNSISVMPAQKITKPAAKYGIPLAYKKYGDKKLHE 280 290 300 310 320 330 >>NP_001186328 (OMIM: 263520,604588) serine/threonine-pr (1189 aa) initn: 695 init1: 695 opt: 754 Z-score: 347.7 bits: 76.1 E(85289): 1.3e-12 Smith-Waterman score: 754; 42.3% identity (75.0% similar) in 260 aa overlap (52-311:4-261) 30 40 50 60 70 80 pF1KA1 SGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGRGAFGEATLYRRTEDDSLVVWK :. .. .:.:.::.: : . ::: : : NP_001 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIK 10 20 30 90 100 110 120 130 140 pF1KA1 EVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKIL :....:.: :::... :...:: ..: ::. : . : .: .: : ..::.::.:. .: NP_001 EINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRIN 40 50 60 70 80 90 150 160 170 180 190 200 pF1KA1 RQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKL :: ::.:.... .. :: :.. .: :::::::. :::::: . ..:::.:.:. : NP_001 AQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVL 100 110 120 130 140 150 210 220 230 240 250 260 pF1KA1 NSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCV :: .:.: .:::::.:::.:.. :: ::::::.:::..:: :::..:.: . :: . NP_001 NSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVL 160 170 180 190 200 210 270 280 290 300 310 320 pF1KA1 KIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTL ::..: .. : .:: .: ..: . . ..:..::... .:.. .. :: NP_001 KIISG--SFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLI 220 230 240 250 260 270 330 340 350 360 370 380 pF1KA1 LNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQKLDVIKSGCSARQVCAGNTHF NP_001 AEEFCLKTFSKFGSQPIPAKRPASGQNSISVMPAQKITKPAAKYGIPLAYKKYGDKKLHE 280 290 300 310 320 330 >>NP_001186329 (OMIM: 263520,604588) serine/threonine-pr (1214 aa) initn: 695 init1: 695 opt: 754 Z-score: 347.6 bits: 76.1 E(85289): 1.3e-12 Smith-Waterman score: 754; 42.3% identity (75.0% similar) in 260 aa overlap (52-311:4-261) 30 40 50 60 70 80 pF1KA1 SGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGRGAFGEATLYRRTEDDSLVVWK :. .. .:.:.::.: : . ::: : : NP_001 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIK 10 20 30 90 100 110 120 130 140 pF1KA1 EVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKIL :....:.: :::... :...:: ..: ::. : . : .: .: : ..::.::.:. .: NP_001 EINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRIN 40 50 60 70 80 90 150 160 170 180 190 200 pF1KA1 RQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKL :: ::.:.... .. :: :.. .: :::::::. :::::: . ..:::.:.:. : NP_001 AQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVL 100 110 120 130 140 150 210 220 230 240 250 260 pF1KA1 NSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCV :: .:.: .:::::.:::.:.. :: ::::::.:::..:: :::..:.: . :: . NP_001 NSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVL 160 170 180 190 200 210 270 280 290 300 310 320 pF1KA1 KIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTL ::..: .. : .:: .: ..: . . ..:..::... .:.. .. :: NP_001 KIISG--SFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLI 220 230 240 250 260 270 330 340 350 360 370 380 pF1KA1 LNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQKLDVIKSGCSARQVCAGNTHF NP_001 AEEFCLKTFSKFGSQPIPAKRPASGQNSISVMPAQKITKPAAKYGIPLAYKKYGDKKLHE 280 290 300 310 320 330 >>XP_011530306 (OMIM: 263520,604588) PREDICTED: serine/t (1214 aa) initn: 695 init1: 695 opt: 754 Z-score: 347.6 bits: 76.1 E(85289): 1.3e-12 Smith-Waterman score: 754; 42.3% identity (75.0% similar) in 260 aa overlap (52-311:4-261) 30 40 50 60 70 80 pF1KA1 SGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGRGAFGEATLYRRTEDDSLVVWK :. .. .:.:.::.: : . ::: : : XP_011 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIK 10 20 30 90 100 110 120 130 140 pF1KA1 EVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKIL :....:.: :::... :...:: ..: ::. : . : .: .: : ..::.::.:. .: XP_011 EINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRIN 40 50 60 70 80 90 150 160 170 180 190 200 pF1KA1 RQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKL :: ::.:.... .. :: :.. .: :::::::. :::::: . ..:::.:.:. : XP_011 AQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVL 100 110 120 130 140 150 210 220 230 240 250 260 pF1KA1 NSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCV :: .:.: .:::::.:::.:.. :: ::::::.:::..:: :::..:.: . :: . XP_011 NSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVL 160 170 180 190 200 210 270 280 290 300 310 320 pF1KA1 KIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTL ::..: .. : .:: .: ..: . . ..:..::... .:.. .. :: XP_011 KIISG--SFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLI 220 230 240 250 260 270 330 340 350 360 370 380 pF1KA1 LNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQKLDVIKSGCSARQVCAGNTHF XP_011 AEEFCLKTFSKFGSQPIPAKRPASGQNSISVMPAQKITKPAAKYGIPLAYKKYGDKKLHE 280 290 300 310 320 330 >>XP_006714291 (OMIM: 263520,604588) PREDICTED: serine/t (1227 aa) initn: 695 init1: 695 opt: 754 Z-score: 347.5 bits: 76.1 E(85289): 1.3e-12 Smith-Waterman score: 754; 42.3% identity (75.0% similar) in 260 aa overlap (52-311:4-261) 30 40 50 60 70 80 pF1KA1 SGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGRGAFGEATLYRRTEDDSLVVWK :. .. .:.:.::.: : . ::: : : XP_006 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIK 10 20 30 90 100 110 120 130 140 pF1KA1 EVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKIL :....:.: :::... :...:: ..: ::. : . : .: .: : ..::.::.:. .: XP_006 EINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRIN 40 50 60 70 80 90 150 160 170 180 190 200 pF1KA1 RQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKL :: ::.:.... .. :: :.. .: :::::::. :::::: . ..:::.:.:. : XP_006 AQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVL 100 110 120 130 140 150 210 220 230 240 250 260 pF1KA1 NSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCV :: .:.: .:::::.:::.:.. :: ::::::.:::..:: :::..:.: . :: . XP_006 NSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVL 160 170 180 190 200 210 270 280 290 300 310 320 pF1KA1 KIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTL ::..: .. : .:: .: ..: . . ..:..::... .:.. .. :: XP_006 KIISG--SFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLI 220 230 240 250 260 270 330 340 350 360 370 380 pF1KA1 LNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQKLDVIKSGCSARQVCAGNTHF XP_006 AEEFCLKTFSKFGSQPIPAKRPASGQNSISVMPAQKITKPAAKYGIPLAYKKYGDKKLHE 280 290 300 310 320 330 >>NP_001186327 (OMIM: 263520,604588) serine/threonine-pr (1242 aa) initn: 695 init1: 695 opt: 754 Z-score: 347.5 bits: 76.1 E(85289): 1.3e-12 Smith-Waterman score: 754; 42.3% identity (75.0% similar) in 260 aa overlap (52-311:4-261) 30 40 50 60 70 80 pF1KA1 SGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGRGAFGEATLYRRTEDDSLVVWK :. .. .:.:.::.: : . ::: : : NP_001 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIK 10 20 30 90 100 110 120 130 140 pF1KA1 EVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKIL :....:.: :::... :...:: ..: ::. : . : .: .: : ..::.::.:. .: NP_001 EINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRIN 40 50 60 70 80 90 150 160 170 180 190 200 pF1KA1 RQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKL :: ::.:.... .. :: :.. .: :::::::. :::::: . ..:::.:.:. : NP_001 AQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVL 100 110 120 130 140 150 210 220 230 240 250 260 pF1KA1 NSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCV :: .:.: .:::::.:::.:.. :: ::::::.:::..:: :::..:.: . :: . NP_001 NSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVL 160 170 180 190 200 210 270 280 290 300 310 320 pF1KA1 KIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTL ::..: .. : .:: .: ..: . . ..:..::... .:.. .. :: NP_001 KIISG--SFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLI 220 230 240 250 260 270 330 340 350 360 370 380 pF1KA1 LNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQKLDVIKSGCSARQVCAGNTHF NP_001 AEEFCLKTFSKFGSQPIPAKRPASGQNSISVMPAQKITKPAAKYGIPLAYKKYGDKKLHE 280 290 300 310 320 330 979 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 01:54:51 2016 done: Fri Nov 4 01:54:53 2016 Total Scan time: 15.310 Total Display time: 0.230 Function used was FASTA [36.3.4 Apr, 2011]