FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0023, 2115 aa 1>>>pF1KB0023 2115 - 2115 aa - 2115 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 14.9020+/-0.00169; mu= -18.4042+/- 0.099 mean_var=636.2002+/-137.526, 0's: 0 Z-trim(110.0): 231 B-trim: 0 in 0/52 Lambda= 0.050848 statistics sampled from 11075 (11269) to 11075 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.637), E-opt: 0.2 (0.346), width: 16 Scan time: 7.630 The best scores are: opt bits E(32554) CCDS31633.1 NUMA1 gene_id:4926|Hs108|chr11 (2115) 13255 989.8 0 CCDS66156.1 NUMA1 gene_id:4926|Hs108|chr11 (2101) 9699 728.9 5.3e-209 CCDS41396.1 TCHH gene_id:7062|Hs108|chr1 (1943) 775 74.3 5.9e-12 >>CCDS31633.1 NUMA1 gene_id:4926|Hs108|chr11 (2115 aa) initn: 13255 init1: 13255 opt: 13255 Z-score: 5275.5 bits: 989.8 E(32554): 0 Smith-Waterman score: 13255; 100.0% identity (100.0% similar) in 2115 aa overlap (1-2115:1-2115) 10 20 30 40 50 60 pF1KB0 MTLHATRGAALLSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIHGTEEGQQILKQPVSER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 MTLHATRGAALLSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIHGTEEGQQILKQPVSER 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 LDFVCSFLQKNRKHPSSPECLVSAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 LDFVCSFLQKNRKHPSSPECLVSAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 YKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 YKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 FLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 FLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAEN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 RKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 RKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 QLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 QLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 EAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 EAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB0 AKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 AKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB0 QQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 QQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB0 AALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 AALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB0 TARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 TARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB0 EKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 EKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB0 ETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 ETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB0 ECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 ECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLAD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB0 DLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 DLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQF 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB0 CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB0 ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKEL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB0 EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQ 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KB0 EQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 EQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQ 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KB0 DHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 DHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESE 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KB0 KSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 KSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAE 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KB0 RAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 RAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKR 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KB0 HREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 HREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSML 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KB0 KKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 KKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQS 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KB0 TARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 TARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLAD 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KB0 SDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 SDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTH 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KB0 YDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 YDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQV 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KB0 RSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 RSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSK 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 pF1KB0 LPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 LPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDS 1750 1760 1770 1780 1790 1800 1810 1820 1830 1840 1850 1860 pF1KB0 GRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAPASQASLRATSSTQSLARL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 GRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAPASQASLRATSSTQSLARL 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 pF1KB0 GSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 GSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRI 1870 1880 1890 1900 1910 1920 1930 1940 1950 1960 1970 1980 pF1KB0 AELQQRNRVCPPHLKTCYPLESRPSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 AELQQRNRVCPPHLKTCYPLESRPSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTG 1930 1940 1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 pF1KB0 ITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQKKAAPASTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 ITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQKKAAPASTK 1990 2000 2010 2020 2030 2040 2050 2060 2070 2080 2090 2100 pF1KB0 QADRRQSMAFSILNTPKKLGNSLLRRGASKKALSKASPNTRSGTRRSPRIATTTASAATA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 QADRRQSMAFSILNTPKKLGNSLLRRGASKKALSKASPNTRSGTRRSPRIATTTASAATA 2050 2060 2070 2080 2090 2100 2110 pF1KB0 AAIGATPRAKGKAKH ::::::::::::::: CCDS31 AAIGATPRAKGKAKH 2110 >>CCDS66156.1 NUMA1 gene_id:4926|Hs108|chr11 (2101 aa) initn: 9615 init1: 9615 opt: 9699 Z-score: 3865.7 bits: 728.9 E(32554): 5.3e-209 Smith-Waterman score: 13130; 99.3% identity (99.3% similar) in 2115 aa overlap (1-2115:1-2101) 10 20 30 40 50 60 pF1KB0 MTLHATRGAALLSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIHGTEEGQQILKQPVSER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 MTLHATRGAALLSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIHGTEEGQQILKQPVSER 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 LDFVCSFLQKNRKHPSSPECLVSAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 LDFVCSFLQKNRKHPSSPECLVSAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 YKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 YKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 FLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 FLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAEN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 RKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 RKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 QLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 QLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 EAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 EAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB0 AKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 AKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB0 QQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 QQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB0 AALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 AALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB0 TARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 TARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB0 EKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 EKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB0 ETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 ETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB0 ECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 ECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLAD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB0 DLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 DLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQF 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB0 CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB0 ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKEL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB0 EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQ 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KB0 EQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 EQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQ 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KB0 DHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 DHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESE 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KB0 KSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 KSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAE 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KB0 RAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 RAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKR 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KB0 HREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 HREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSML 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KB0 KKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 KKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQS 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KB0 TARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLAD :::::::::::::::::::::::::::::::::::::: :::::::: CCDS66 TARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVE--------------ELSKKLAD 1510 1520 1530 1540 1570 1580 1590 1600 1610 1620 pF1KB0 SDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 SDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTH 1550 1560 1570 1580 1590 1600 1630 1640 1650 1660 1670 1680 pF1KB0 YDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 YDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQV 1610 1620 1630 1640 1650 1660 1690 1700 1710 1720 1730 1740 pF1KB0 RSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 RSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSK 1670 1680 1690 1700 1710 1720 1750 1760 1770 1780 1790 1800 pF1KB0 LPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 LPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDS 1730 1740 1750 1760 1770 1780 1810 1820 1830 1840 1850 1860 pF1KB0 GRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAPASQASLRATSSTQSLARL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 GRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAPASQASLRATSSTQSLARL 1790 1800 1810 1820 1830 1840 1870 1880 1890 1900 1910 1920 pF1KB0 GSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 GSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRI 1850 1860 1870 1880 1890 1900 1930 1940 1950 1960 1970 1980 pF1KB0 AELQQRNRVCPPHLKTCYPLESRPSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 AELQQRNRVCPPHLKTCYPLESRPSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTG 1910 1920 1930 1940 1950 1960 1990 2000 2010 2020 2030 2040 pF1KB0 ITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQKKAAPASTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 ITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQKKAAPASTK 1970 1980 1990 2000 2010 2020 2050 2060 2070 2080 2090 2100 pF1KB0 QADRRQSMAFSILNTPKKLGNSLLRRGASKKALSKASPNTRSGTRRSPRIATTTASAATA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 QADRRQSMAFSILNTPKKLGNSLLRRGASKKALSKASPNTRSGTRRSPRIATTTASAATA 2030 2040 2050 2060 2070 2080 2110 pF1KB0 AAIGATPRAKGKAKH ::::::::::::::: CCDS66 AAIGATPRAKGKAKH 2090 2100 >>CCDS41396.1 TCHH gene_id:7062|Hs108|chr1 (1943 aa) initn: 469 init1: 169 opt: 775 Z-score: 328.1 bits: 74.3 E(32554): 5.9e-12 Smith-Waterman score: 987; 23.9% identity (54.5% similar) in 1546 aa overlap (210-1715:463-1879) 180 190 200 210 220 230 pF1KB0 RFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLA-DERSNRDE--LELE .: . ...: :.:: :.. .: : :.:: CCDS41 RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLE 440 450 460 470 480 490 240 250 260 270 280 290 pF1KB0 LAENRKLLTEKDAQIAMMQQ--RIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHE : :. ... :. :. : .:: .:.. . .: . :...: : .. CCDS41 EEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEE----RREQ 500 510 520 530 540 300 310 320 330 340 350 pF1KB0 TLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQE ::. .. . :. . ...... .:: : .: :: . :.:. .: :.. : .: CCDS41 LLKREEEKRLEQERREQRLKREQEERRDQLLK-REEERRQQRLKREQEERLEQRLK--RE 550 560 570 580 590 600 360 370 380 390 400 410 pF1KB0 WLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQ .:. : :.. . ... :.....:... : :.. .::. . ... . : . CCDS41 EVERLEQEERREQRLKREEPEEERRQQLLKSE-EQEERRQQQLRREQQERREQRLKREEE 610 620 630 640 650 660 420 430 440 450 460 470 pF1KB0 LETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSS : :.:. : .. . . . :. : :. : . .. .... . . :: : ::. CCDS41 EERLEQR---LKREHEEERREQELAEEEQEQARERI---KSRIPKWQWQLESEADARQSK 670 680 690 700 710 480 490 500 510 520 530 pF1KB0 ISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQ . . . .: .. .. . : . ::: : :..: : .:: .:.. . CCDS41 VYSRPRKQEGQRRRQEQEEKRRRRE-----SEL-------QWQEEERAHRQQQEEEQRRD 720 730 740 750 760 540 550 560 570 580 590 pF1KB0 LAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREA .. : .:.. .: :... .:.:.::. ::. ::.. :.. ::.: CCDS41 FTWQWQAEEKSERG-RQRLSARPPLREQRERQLR--AEE----RQQREQRFLPEEEEKEQ 770 780 790 800 810 600 610 620 630 640 650 pF1KB0 SLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEE :.: :.:. ::.:. . . :::: : .:. : . : .:.. : : . CCDS41 RRRQRREREKELQFLEEEEQLQRRERAQQLQ---EEEDGLQED--QERRRSQEQRRDQKW 820 830 840 850 860 870 660 670 680 690 700 710 pF1KB0 LQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVT : ....: :. : :. :::.::: :.: :.:: .: CCDS41 RWQLEEERKRRRHTLYAKPA-LQEQLRKEQQLLQEEE----------EELQ--RE----- 880 890 900 910 720 730 740 750 760 770 pF1KB0 KGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQL :.:::: . :.: : .:. : ..:.......:.. :.:: :: . .::: CCDS41 ----EREKRRRQEQ-ERQYREEEQLQQEEEQLLREEREKRRRQERERQYRK--DKKLQQK 920 930 940 950 960 780 790 800 810 820 830 pF1KB0 GEAHQAETEVLRR--ELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQ : .: :: : . . .. ..: :::..: :.: : .: . . . : CCDS41 EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK-DELQQ 970 980 990 1000 1010 1020 840 850 860 870 pF1KB0 EQLMTLKEECEKAR-----------QELQEAKEKVAGIESHSE--LQISRQQNELAELHA :. . :.:: :: : .:::. .:.. : : ... .. :: . ::. CCDS41 EEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQ 1030 1040 1050 1060 1070 1080 880 890 900 910 920 930 pF1KB0 NLARALQQVQEKEVRAQKL-----ADDLSTLQEKMAATSKEVARLETLVRKAGEQQETAS . . :.. ::. : .. ..:. .:.. .: : . : :. :..:. . CCDS41 EEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQ 1090 1100 1110 1120 1130 1140 940 950 960 970 980 990 pF1KB0 RE---LVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMES .: : .:: . :. . :: ::. :: :.. .: :.: : : CCDS41 EEEQLLREEPEK---RRRQELE----RQY-----------REEEELQQEEEQL---LREE 1150 1160 1170 1180 1000 1010 1020 1030 1040 1050 pF1KB0 QGQQQEERGQQEREVARLT-QERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQE : ....:: .: :: .: :.: . : .. . . : . .::. ...: .. CCDS41 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGREN 1190 1200 1210 1220 1230 1240 1060 1070 1080 1090 1100 pF1KB0 ALAHALTEKEGKD----QELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSG . : ... .: :.: .: : . : .. :. :. .: ... ..:. . CCDS41 EQFRQLEDSQLRDRQSQQDLQHLLGEQ--QERDREQERRRWQQRDRHFPEEEQLERE--- 1250 1260 1270 1280 1290 1300 1110 1120 1130 1140 1150 1160 pF1KB0 AQSEAAGRTEPTGPKLEALRAEV--SKLEQQCQKQQEQADSLERSLEAERASRAERDSAL :.:: : . . . . :: : .. .:. ... .. ..: . : . : ::: . CCDS41 EQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKF 1310 1320 1330 1340 1350 1360 1170 1180 1190 1200 1210 1220 pF1KB0 ETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKN . . . .:..... . .. : .:: : . :. : : . . : :. :... CCDS41 REEELRHQEQGRKFLEEEQRLRRQERE-RKFLKEEQQLRCQEREQQLRQDRDRKFREEEQ 1370 1380 1390 1400 1410 1420 1230 1240 1250 1260 1270 1280 pF1KB0 SLISSLEEEVSILN--RQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSAR .: : :.. .. . .:: ..: : : :.. . ..:. .:..:. .::: : .. . CCDS41 QL-SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQ-EREEQQLH 1430 1440 1450 1460 1470 1290 1300 1310 1320 1330 1340 pF1KB0 AAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQA ::. . :: :.::.. . .. ..::.. . :: . . :.::.:.:: CCDS41 RQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQ 1480 1490 1500 1510 1520 1530 1350 1360 1370 1380 1390 1400 pF1KB0 LSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHRE-ELEQSKQAAGGLRAELLR : . . : .. ..: :. . .: . ..: :. .::..: .: CCDS41 LRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK----------VR 1540 1550 1560 1570 1580 1410 1420 1430 1440 1450 1460 pF1KB0 AQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLG :.. ... .:.. .:: :::: :. ... . :: :... .: . CCDS41 RQEQERKFMEDEQQLRRQE-GQQQLRQERDRK------FREDEQLLQEREEQQLHRQERD 1590 1600 1610 1620 1630 1640 1470 1480 1490 1500 1510 1520 pF1KB0 RQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLE :.::: : . :.. :.: : : . .. :: : . . : ... : CCDS41 RKFLEEEPQLRRQEREQQL---RHDRDRKF-----------REEEQLLQEGEEQQLRRQE 1650 1660 1670 1680 1530 1540 1550 1560 1570 1580 pF1KB0 ERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGE . ..:.::.:.: : .. . .:.:: . .:: .:. . .: . .:. : . . CCDS41 RDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRK 1690 1700 1710 1720 1730 1740 1590 1600 1610 1620 1630 1640 pF1KB0 SQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQL .: : :. . .: : . ..... ... . :. . . . .. ..:: ....: ::: CCDS41 ILEEEQ-LRPEREEQQLRRQERDR---KFR-EEEQLRQEREEQQLRSQESDRKFREEEQL 1750 1760 1770 1780 1790 1800 1650 1660 1670 1680 1690 pF1KB0 QKENKE--LRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGK ..: .: :: . . .. .. :. .: :: :. . : : : ... :. . CCDS41 RQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQE 1810 1820 1830 1840 1850 1860 1700 1710 1720 1730 1740 1750 pF1KB0 FQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPI . . . .: . : CCDS41 LWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFASV 1870 1880 1890 1900 1910 1920 2115 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 01:59:18 2016 done: Fri Nov 4 01:59:19 2016 Total Scan time: 7.630 Total Display time: 0.590 Function used was FASTA [36.3.4 Apr, 2011]