FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0026, 1058 aa 1>>>pF1KB0026 1058 - 1058 aa - 1058 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.8628+/-0.000411; mu= 9.6494+/- 0.026 mean_var=131.9004+/-27.281, 0's: 0 Z-trim(115.5): 17 B-trim: 250 in 1/50 Lambda= 0.111674 statistics sampled from 25926 (25929) to 25926 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.646), E-opt: 0.2 (0.304), width: 16 Scan time: 13.380 The best scores are: opt bits E(85289) XP_011525656 (OMIM: 602388) PREDICTED: symplekin i (1274) 6148 1002.8 0 XP_005259343 (OMIM: 602388) PREDICTED: symplekin i (1274) 6148 1002.8 0 NP_004810 (OMIM: 602388) symplekin [Homo sapiens] (1274) 6148 1002.8 0 >>XP_011525656 (OMIM: 602388) PREDICTED: symplekin isofo (1274 aa) initn: 6148 init1: 6148 opt: 6148 Z-score: 5355.1 bits: 1002.8 E(85289): 0 Smith-Waterman score: 6148; 99.7% identity (99.8% similar) in 968 aa overlap (1-968:1-968) 10 20 30 40 50 60 pF1KB0 MASGSGDSVTRRSVASQFFTQEEGPGIDGMTTSERVVDLLNQAALITNDSKITVLKQVQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MASGSGDSVTRRSVASQFFTQEEGPGIDGMTTSERVVDLLNQAALITNDSKITVLKQVQE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 LIINKDPTLLDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLKLIANLNMLLRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LIINKDPTLLDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLKLIANLNMLLRD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 ENVNVVKKAILTMTQLYKVALQWMVKSRVISELQEACWDMVSAMAGDIILLLDSDNDGIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENVNVVKKAILTMTQLYKVALQWMVKSRVISELQEACWDMVSAMAGDIILLLDSDNDGIR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 THAIKFVEGLIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYIQYNVLWEEGKAALEQLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 THAIKFVEGLIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYIQYNVLWEEGKAALEQLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 KFMVHPAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KFMVHPAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 LKLHLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKLHLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 KLEPNLGEDDEDKDLEPGPSGTSKASAQISGQSDTDITAEFLQPLLTPDNVANLVLISMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLEPNLGEDDEDKDLEPGPSGTSKASAQISGQSDTDITAEFLQPLLTPDNVANLVLISMV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 YLPEAMPASFQAIYTPVESAGTEAQIKHLARLMATQMTAAGLGPGVEQTKQCKEEPKEEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YLPEAMPASFQAIYTPVESAGTEAQIKHLARLMATQMTAAGLGPGVEQTKQCKEEPKEEK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB0 VVKTESVLIKRRLSAQGQAISVVGSLSSMSPLEEEAPQAKRRPEPIIPVTQPRLAGAGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVKTESVLIKRRLSAQGQAISVVGSLSSMSPLEEEAPQAKRRPEPIIPVTQPRLAGAGGR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB0 KKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACSGAAQVRIKILASLVTQFNSGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACSGAAQVRIKILASLVTQFNSGL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB0 KAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGASGSLDKYEDCLIRLLSGLQEKPDQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGASGSLDKYEDCLIRLLSGLQEKPDQK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB0 DGIFTKVVLEAPLITESALEVVRKYCEDESRTYLGMSTLRDLIFKRPSRQFQYLHVLLDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGIFTKVVLEAPLITESALEVVRKYCEDESRTYLGMSTLRDLIFKRPSRQFQYLHVLLDL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB0 SSHEKDKVRSQALLFIKRMYEKEQLREYVEKFALNYLQLLVHPNPPSVLFGADKDTEVAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSHEKDKVRSQALLFIKRMYEKEQLREYVEKFALNYLQLLVHPNPPSVLFGADKDTEVAA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB0 PWTEETVKQCLYLYLALLPQNHKLIHELAAVYTEAIADIKRTVLRVIEQPIRGMGMNSPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PWTEETVKQCLYLYLALLPQNHKLIHELAAVYTEAIADIKRTVLRVIEQPIRGMGMNSPE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB0 LLLLVENCPKGAETLVTRCLHSLTDKVPPSPELVKRVRDLYHKRLPDVRFLIPVLNGLEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLLLVENCPKGAETLVTRCLHSLTDKVPPSPELVKRVRDLYHKRLPDVRFLIPVLNGLEK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB0 KEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSVKCDMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSVKCDMK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB0 SIIKGEALPPHSSGLAPATPGQDLSHPHAPTGICQVKDCHSQPHLRALESHLPPSLLFLP ::::. : XP_011 SIIKATNLCFAERNVYTSEVLAVVMQQLMEQSPLPMLLMRTVIQSLTMYPRLGGFVMNIL 970 980 990 1000 1010 1020 >>XP_005259343 (OMIM: 602388) PREDICTED: symplekin isofo (1274 aa) initn: 6148 init1: 6148 opt: 6148 Z-score: 5355.1 bits: 1002.8 E(85289): 0 Smith-Waterman score: 6148; 99.7% identity (99.8% similar) in 968 aa overlap (1-968:1-968) 10 20 30 40 50 60 pF1KB0 MASGSGDSVTRRSVASQFFTQEEGPGIDGMTTSERVVDLLNQAALITNDSKITVLKQVQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MASGSGDSVTRRSVASQFFTQEEGPGIDGMTTSERVVDLLNQAALITNDSKITVLKQVQE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 LIINKDPTLLDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLKLIANLNMLLRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LIINKDPTLLDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLKLIANLNMLLRD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 ENVNVVKKAILTMTQLYKVALQWMVKSRVISELQEACWDMVSAMAGDIILLLDSDNDGIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ENVNVVKKAILTMTQLYKVALQWMVKSRVISELQEACWDMVSAMAGDIILLLDSDNDGIR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 THAIKFVEGLIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYIQYNVLWEEGKAALEQLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 THAIKFVEGLIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYIQYNVLWEEGKAALEQLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 KFMVHPAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KFMVHPAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 LKLHLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKLHLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 KLEPNLGEDDEDKDLEPGPSGTSKASAQISGQSDTDITAEFLQPLLTPDNVANLVLISMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KLEPNLGEDDEDKDLEPGPSGTSKASAQISGQSDTDITAEFLQPLLTPDNVANLVLISMV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 YLPEAMPASFQAIYTPVESAGTEAQIKHLARLMATQMTAAGLGPGVEQTKQCKEEPKEEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YLPEAMPASFQAIYTPVESAGTEAQIKHLARLMATQMTAAGLGPGVEQTKQCKEEPKEEK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB0 VVKTESVLIKRRLSAQGQAISVVGSLSSMSPLEEEAPQAKRRPEPIIPVTQPRLAGAGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VVKTESVLIKRRLSAQGQAISVVGSLSSMSPLEEEAPQAKRRPEPIIPVTQPRLAGAGGR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB0 KKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACSGAAQVRIKILASLVTQFNSGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACSGAAQVRIKILASLVTQFNSGL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB0 KAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGASGSLDKYEDCLIRLLSGLQEKPDQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGASGSLDKYEDCLIRLLSGLQEKPDQK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB0 DGIFTKVVLEAPLITESALEVVRKYCEDESRTYLGMSTLRDLIFKRPSRQFQYLHVLLDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DGIFTKVVLEAPLITESALEVVRKYCEDESRTYLGMSTLRDLIFKRPSRQFQYLHVLLDL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB0 SSHEKDKVRSQALLFIKRMYEKEQLREYVEKFALNYLQLLVHPNPPSVLFGADKDTEVAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSHEKDKVRSQALLFIKRMYEKEQLREYVEKFALNYLQLLVHPNPPSVLFGADKDTEVAA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB0 PWTEETVKQCLYLYLALLPQNHKLIHELAAVYTEAIADIKRTVLRVIEQPIRGMGMNSPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PWTEETVKQCLYLYLALLPQNHKLIHELAAVYTEAIADIKRTVLRVIEQPIRGMGMNSPE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB0 LLLLVENCPKGAETLVTRCLHSLTDKVPPSPELVKRVRDLYHKRLPDVRFLIPVLNGLEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLLLVENCPKGAETLVTRCLHSLTDKVPPSPELVKRVRDLYHKRLPDVRFLIPVLNGLEK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB0 KEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSVKCDMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSVKCDMK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB0 SIIKGEALPPHSSGLAPATPGQDLSHPHAPTGICQVKDCHSQPHLRALESHLPPSLLFLP ::::. : XP_005 SIIKATNLCFAERNVYTSEVLAVVMQQLMEQSPLPMLLMRTVIQSLTMYPRLGGFVMNIL 970 980 990 1000 1010 1020 >>NP_004810 (OMIM: 602388) symplekin [Homo sapiens] (1274 aa) initn: 6148 init1: 6148 opt: 6148 Z-score: 5355.1 bits: 1002.8 E(85289): 0 Smith-Waterman score: 6148; 99.7% identity (99.8% similar) in 968 aa overlap (1-968:1-968) 10 20 30 40 50 60 pF1KB0 MASGSGDSVTRRSVASQFFTQEEGPGIDGMTTSERVVDLLNQAALITNDSKITVLKQVQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MASGSGDSVTRRSVASQFFTQEEGPGIDGMTTSERVVDLLNQAALITNDSKITVLKQVQE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 LIINKDPTLLDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLKLIANLNMLLRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LIINKDPTLLDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLKLIANLNMLLRD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 ENVNVVKKAILTMTQLYKVALQWMVKSRVISELQEACWDMVSAMAGDIILLLDSDNDGIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ENVNVVKKAILTMTQLYKVALQWMVKSRVISELQEACWDMVSAMAGDIILLLDSDNDGIR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 THAIKFVEGLIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYIQYNVLWEEGKAALEQLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 THAIKFVEGLIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYIQYNVLWEEGKAALEQLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 KFMVHPAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KFMVHPAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 LKLHLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LKLHLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 KLEPNLGEDDEDKDLEPGPSGTSKASAQISGQSDTDITAEFLQPLLTPDNVANLVLISMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KLEPNLGEDDEDKDLEPGPSGTSKASAQISGQSDTDITAEFLQPLLTPDNVANLVLISMV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 YLPEAMPASFQAIYTPVESAGTEAQIKHLARLMATQMTAAGLGPGVEQTKQCKEEPKEEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 YLPEAMPASFQAIYTPVESAGTEAQIKHLARLMATQMTAAGLGPGVEQTKQCKEEPKEEK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB0 VVKTESVLIKRRLSAQGQAISVVGSLSSMSPLEEEAPQAKRRPEPIIPVTQPRLAGAGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VVKTESVLIKRRLSAQGQAISVVGSLSSMSPLEEEAPQAKRRPEPIIPVTQPRLAGAGGR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB0 KKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACSGAAQVRIKILASLVTQFNSGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACSGAAQVRIKILASLVTQFNSGL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB0 KAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGASGSLDKYEDCLIRLLSGLQEKPDQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGASGSLDKYEDCLIRLLSGLQEKPDQK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB0 DGIFTKVVLEAPLITESALEVVRKYCEDESRTYLGMSTLRDLIFKRPSRQFQYLHVLLDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DGIFTKVVLEAPLITESALEVVRKYCEDESRTYLGMSTLRDLIFKRPSRQFQYLHVLLDL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB0 SSHEKDKVRSQALLFIKRMYEKEQLREYVEKFALNYLQLLVHPNPPSVLFGADKDTEVAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SSHEKDKVRSQALLFIKRMYEKEQLREYVEKFALNYLQLLVHPNPPSVLFGADKDTEVAA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB0 PWTEETVKQCLYLYLALLPQNHKLIHELAAVYTEAIADIKRTVLRVIEQPIRGMGMNSPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PWTEETVKQCLYLYLALLPQNHKLIHELAAVYTEAIADIKRTVLRVIEQPIRGMGMNSPE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB0 LLLLVENCPKGAETLVTRCLHSLTDKVPPSPELVKRVRDLYHKRLPDVRFLIPVLNGLEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LLLLVENCPKGAETLVTRCLHSLTDKVPPSPELVKRVRDLYHKRLPDVRFLIPVLNGLEK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB0 KEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSVKCDMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSVKCDMK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB0 SIIKGEALPPHSSGLAPATPGQDLSHPHAPTGICQVKDCHSQPHLRALESHLPPSLLFLP ::::. : NP_004 SIIKATNLCFAERNVYTSEVLAVVMQQLMEQSPLPMLLMRTVIQSLTMYPRLGGFVMNIL 970 980 990 1000 1010 1020 1058 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 02:35:17 2016 done: Sat Nov 5 02:35:19 2016 Total Scan time: 13.380 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]