Result of FASTA (omim) for
pF1KB0048
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB0048, 1756 aa
1>>>pF1KB0048 1756 - 1756 aa - 1756 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 13.7474+/-0.000509; mu= -14.7928+/- 0.032
mean_var=500.6808+/-104.710, 0's: 0 Z-trim(120.3): 155 B-trim: 578 in 1/60
Lambda= 0.057318
statistics sampled from 35246 (35448) to 35246 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.416), width: 16
Scan time: 18.820
The best scores are: opt bits E(85289)
NP_001317168 (OMIM: 601009) tight junction protein (1768) 11841 995.6 0
NP_001287954 (OMIM: 601009) tight junction protein (1835) 11841 995.6 0
XP_016878018 (OMIM: 601009) PREDICTED: tight junct (1755) 11529 969.8 0
XP_016878017 (OMIM: 601009) PREDICTED: tight junct (1759) 11529 969.8 0
XP_011520274 (OMIM: 601009) PREDICTED: tight junct (1848) 11529 969.8 0
NP_003248 (OMIM: 601009) tight junction protein ZO (1748) 11487 966.3 0
XP_005254674 (OMIM: 601009) PREDICTED: tight junct (1841) 11487 966.3 0
XP_016878011 (OMIM: 601009) PREDICTED: tight junct (1865) 9532 804.6 0
XP_016878012 (OMIM: 601009) PREDICTED: tight junct (1858) 9508 802.6 0
XP_016878016 (OMIM: 601009) PREDICTED: tight junct (1783) 9336 788.4 0
XP_016878015 (OMIM: 601009) PREDICTED: tight junct (1785) 9336 788.4 0
XP_016878014 (OMIM: 601009) PREDICTED: tight junct (1789) 9336 788.4 0
XP_016878010 (OMIM: 601009) PREDICTED: tight junct (1878) 9336 788.4 0
XP_016878020 (OMIM: 601009) PREDICTED: tight junct (1452) 7217 613.1 5.9e-174
XP_016878013 (OMIM: 601009) PREDICTED: tight junct (1798) 6202 529.3 1.3e-148
NP_783297 (OMIM: 601009) tight junction protein ZO (1668) 6174 526.9 6e-148
XP_016878019 (OMIM: 601009) PREDICTED: tight junct (1688) 6174 526.9 6.1e-148
NP_001287955 (OMIM: 601009) tight junction protein (1692) 6174 526.9 6.1e-148
XP_005254677 (OMIM: 601009) PREDICTED: tight junct (1761) 6174 526.9 6.3e-148
XP_005254676 (OMIM: 601009) PREDICTED: tight junct (1781) 6174 526.9 6.3e-148
XP_011517510 (OMIM: 607709,607748,615878) PREDICTE (1167) 2024 183.6 9.2e-45
XP_011517511 (OMIM: 607709,607748,615878) PREDICTE (1167) 2024 183.6 9.2e-45
XP_011517509 (OMIM: 607709,607748,615878) PREDICTE (1167) 2024 183.6 9.2e-45
XP_011517508 (OMIM: 607709,607748,615878) PREDICTE (1167) 2024 183.6 9.2e-45
NP_004808 (OMIM: 607709,607748,615878) tight junct (1190) 2024 183.6 9.3e-45
XP_005252371 (OMIM: 607709,607748,615878) PREDICTE (1194) 2024 183.6 9.4e-45
XP_016870815 (OMIM: 607709,607748,615878) PREDICTE (1213) 2024 183.6 9.5e-45
NP_001163887 (OMIM: 607709,607748,615878) tight ju (1221) 2024 183.6 9.5e-45
XP_011517506 (OMIM: 607709,607748,615878) PREDICTE (1130) 1988 180.6 7.1e-44
XP_016870816 (OMIM: 607709,607748,615878) PREDICTE (1153) 1988 180.7 7.2e-44
NP_001163886 (OMIM: 607709,607748,615878) tight ju (1157) 1988 180.7 7.2e-44
NP_001163885 (OMIM: 607709,607748,615878) tight ju (1020) 1961 178.4 3.1e-43
NP_963923 (OMIM: 607709,607748,615878) tight junct (1043) 1961 178.4 3.1e-43
XP_016870817 (OMIM: 607709,607748,615878) PREDICTE (1047) 1961 178.4 3.1e-43
NP_001254489 (OMIM: 612689) tight junction protein ( 919) 756 78.7 2.8e-13
NP_001254490 (OMIM: 612689) tight junction protein ( 928) 756 78.7 2.8e-13
>>NP_001317168 (OMIM: 601009) tight junction protein ZO- (1768 aa)
initn: 11841 init1: 11841 opt: 11841 Z-score: 5309.4 bits: 995.6 E(85289): 0
Smith-Waterman score: 11841; 100.0% identity (100.0% similar) in 1756 aa overlap (1-1756:13-1768)
10 20 30 40
pF1KB0 MEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB0 KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB0 PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB0 PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB0 SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB0 GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB0 DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB0 SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB0 EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB0 EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB0 FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB0 LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ
670 680 690 700 710 720
710 720 730 740 750 760
pF1KB0 WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND
730 740 750 760 770 780
770 780 790 800 810 820
pF1KB0 GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT
790 800 810 820 830 840
830 840 850 860 870 880
pF1KB0 SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP
850 860 870 880 890 900
890 900 910 920 930 940
pF1KB0 QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KB0 PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KB0 QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KB0 EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KB0 DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KB0 QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KB0 PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KB0 KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KB0 SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KB0 PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KB0 QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590 1600
pF1KB0 PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA
1570 1580 1590 1600 1610 1620
1610 1620 1630 1640 1650 1660
pF1KB0 VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS
1630 1640 1650 1660 1670 1680
1670 1680 1690 1700 1710 1720
pF1KB0 ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDP
1690 1700 1710 1720 1730 1740
1730 1740 1750
pF1KB0 KTWQNKCLPGDPNYLVGANCVSVLIDHF
::::::::::::::::::::::::::::
NP_001 KTWQNKCLPGDPNYLVGANCVSVLIDHF
1750 1760
>>NP_001287954 (OMIM: 601009) tight junction protein ZO- (1835 aa)
initn: 11841 init1: 11841 opt: 11841 Z-score: 5309.1 bits: 995.6 E(85289): 0
Smith-Waterman score: 11841; 100.0% identity (100.0% similar) in 1756 aa overlap (1-1756:80-1835)
10 20 30
pF1KB0 MEETAIWEQHTVTLHRAPGFGFGIAISGGR
::::::::::::::::::::::::::::::
NP_001 GKPSLRRIKGRLHRSKSLDSMDFCELTSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGR
50 60 70 80 90 100
40 50 60 70 80 90
pF1KB0 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
110 120 130 140 150 160
100 110 120 130 140 150
pF1KB0 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
170 180 190 200 210 220
160 170 180 190 200 210
pF1KB0 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
230 240 250 260 270 280
220 230 240 250 260 270
pF1KB0 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
290 300 310 320 330 340
280 290 300 310 320 330
pF1KB0 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
350 360 370 380 390 400
340 350 360 370 380 390
pF1KB0 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
410 420 430 440 450 460
400 410 420 430 440 450
pF1KB0 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
470 480 490 500 510 520
460 470 480 490 500 510
pF1KB0 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
530 540 550 560 570 580
520 530 540 550 560 570
pF1KB0 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
590 600 610 620 630 640
580 590 600 610 620 630
pF1KB0 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
650 660 670 680 690 700
640 650 660 670 680 690
pF1KB0 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
710 720 730 740 750 760
700 710 720 730 740 750
pF1KB0 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
770 780 790 800 810 820
760 770 780 790 800 810
pF1KB0 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
830 840 850 860 870 880
820 830 840 850 860 870
pF1KB0 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
890 900 910 920 930 940
880 890 900 910 920 930
pF1KB0 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
950 960 970 980 990 1000
940 950 960 970 980 990
pF1KB0 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
1010 1020 1030 1040 1050 1060
1000 1010 1020 1030 1040 1050
pF1KB0 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
1070 1080 1090 1100 1110 1120
1060 1070 1080 1090 1100 1110
pF1KB0 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
1130 1140 1150 1160 1170 1180
1120 1130 1140 1150 1160 1170
pF1KB0 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
1190 1200 1210 1220 1230 1240
1180 1190 1200 1210 1220 1230
pF1KB0 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
1250 1260 1270 1280 1290 1300
1240 1250 1260 1270 1280 1290
pF1KB0 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
1310 1320 1330 1340 1350 1360
1300 1310 1320 1330 1340 1350
pF1KB0 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
1370 1380 1390 1400 1410 1420
1360 1370 1380 1390 1400 1410
pF1KB0 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPI
1430 1440 1450 1460 1470 1480
1420 1430 1440 1450 1460 1470
pF1KB0 QATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKP
1490 1500 1510 1520 1530 1540
1480 1490 1500 1510 1520 1530
pF1KB0 ATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERK
1550 1560 1570 1580 1590 1600
1540 1550 1560 1570 1580 1590
pF1KB0 FESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKY
1610 1620 1630 1640 1650 1660
1600 1610 1620 1630 1640 1650
pF1KB0 QINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGA
1670 1680 1690 1700 1710 1720
1660 1670 1680 1690 1700 1710
pF1KB0 IPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMT
1730 1740 1750 1760 1770 1780
1720 1730 1740 1750
pF1KB0 PDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
1790 1800 1810 1820 1830
>>XP_016878018 (OMIM: 601009) PREDICTED: tight junction (1755 aa)
initn: 11529 init1: 11529 opt: 11529 Z-score: 5170.0 bits: 969.8 E(85289): 0
Smith-Waterman score: 11720; 99.3% identity (99.3% similar) in 1756 aa overlap (1-1756:13-1755)
10 20 30 40
pF1KB0 MEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB0 KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB0 PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB0 PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB0 SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB0 GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB0 DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB0 SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB0 EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB0 EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB0 FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB0 LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ
670 680 690 700 710 720
710 720 730 740 750 760
pF1KB0 WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND
730 740 750 760 770 780
770 780 790 800 810 820
pF1KB0 GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT
790 800 810 820 830 840
830 840 850 860 870 880
pF1KB0 SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP
850 860 870 880 890 900
890 900 910 920 930 940
pF1KB0 QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KB0 PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KB0 QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KB0 EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KB0 DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KB0 QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KB0 PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KB0 KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KB0 SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KB0 PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KB0 QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590 1600
pF1KB0 PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA
1570 1580 1590 1600 1610 1620
1610 1620 1630 1640 1650 1660
pF1KB0 VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS
1630 1640 1650 1660 1670 1680
1670 1680 1690 1700 1710 1720
pF1KB0 ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDP
::::::::::::::::::::::::::::::::::::::::::::: ::
XP_016 ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDG-------------DP
1690 1700 1710 1720
1730 1740 1750
pF1KB0 KTWQNKCLPGDPNYLVGANCVSVLIDHF
::::::::::::::::::::::::::::
XP_016 KTWQNKCLPGDPNYLVGANCVSVLIDHF
1730 1740 1750
>>XP_016878017 (OMIM: 601009) PREDICTED: tight junction (1759 aa)
initn: 11529 init1: 11529 opt: 11529 Z-score: 5170.0 bits: 969.8 E(85289): 0
Smith-Waterman score: 11720; 99.3% identity (99.3% similar) in 1756 aa overlap (1-1756:17-1759)
10 20 30 40
pF1KB0 MEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVI
::::::::::::::::::::::::::::::::::::::::::::
XP_016 MERNTFSMDCHSKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVI
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB0 SDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPV
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB0 SRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSV
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB0 ASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTV
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB0 TENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLA
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB0 SDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPV
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB0 KHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDG
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB0 ILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFT
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB0 NIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLS
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB0 FNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGG
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB0 DRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADV
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB0 AREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRL
670 680 690 700 710 720
710 720 730 740 750 760
pF1KB0 NYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLN
730 740 750 760 770 780
770 780 790 800 810 820
pF1KB0 SMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTD
790 800 810 820 830 840
830 840 850 860 870 880
pF1KB0 SRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYP
850 860 870 880 890 900
890 900 910 920 930 940
pF1KB0 PYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRL
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KB0 EEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQN
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KB0 HVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEH
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KB0 RLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPA
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KB0 PLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYS
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KB0 RSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEED
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KB0 PAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQF
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KB0 SEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIA
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KB0 ASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYA
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KB0 QPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQA
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KB0 AFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSE
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590 1600
pF1KB0 TAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPV
1570 1580 1590 1600 1610 1620
1610 1620 1630 1640 1650 1660
pF1KB0 SPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVC
1630 1640 1650 1660 1670 1680
1670 1680 1690 1700 1710 1720
pF1KB0 RDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSS
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDG-----------
1690 1700 1710 1720
1730 1740 1750
pF1KB0 SGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
::::::::::::::::::::::::::::::
XP_016 --DPKTWQNKCLPGDPNYLVGANCVSVLIDHF
1730 1740 1750
>>XP_011520274 (OMIM: 601009) PREDICTED: tight junction (1848 aa)
initn: 11529 init1: 11529 opt: 11529 Z-score: 5169.7 bits: 969.8 E(85289): 0
Smith-Waterman score: 11720; 99.3% identity (99.3% similar) in 1756 aa overlap (1-1756:106-1848)
10 20 30
pF1KB0 MEETAIWEQHTVTLHRAPGFGFGIAISGGR
::::::::::::::::::::::::::::::
XP_011 GKPSLRRIKGRLHRSKSLDSMDFCELTSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGR
80 90 100 110 120 130
40 50 60 70 80 90
pF1KB0 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
140 150 160 170 180 190
100 110 120 130 140 150
pF1KB0 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
200 210 220 230 240 250
160 170 180 190 200 210
pF1KB0 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
260 270 280 290 300 310
220 230 240 250 260 270
pF1KB0 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
320 330 340 350 360 370
280 290 300 310 320 330
pF1KB0 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
380 390 400 410 420 430
340 350 360 370 380 390
pF1KB0 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
440 450 460 470 480 490
400 410 420 430 440 450
pF1KB0 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
500 510 520 530 540 550
460 470 480 490 500 510
pF1KB0 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
560 570 580 590 600 610
520 530 540 550 560 570
pF1KB0 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
620 630 640 650 660 670
580 590 600 610 620 630
pF1KB0 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
680 690 700 710 720 730
640 650 660 670 680 690
pF1KB0 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
740 750 760 770 780 790
700 710 720 730 740 750
pF1KB0 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
800 810 820 830 840 850
760 770 780 790 800 810
pF1KB0 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
860 870 880 890 900 910
820 830 840 850 860 870
pF1KB0 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
920 930 940 950 960 970
880 890 900 910 920 930
pF1KB0 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
980 990 1000 1010 1020 1030
940 950 960 970 980 990
pF1KB0 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
1040 1050 1060 1070 1080 1090
1000 1010 1020 1030 1040 1050
pF1KB0 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
1100 1110 1120 1130 1140 1150
1060 1070 1080 1090 1100 1110
pF1KB0 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
1160 1170 1180 1190 1200 1210
1120 1130 1140 1150 1160 1170
pF1KB0 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
1220 1230 1240 1250 1260 1270
1180 1190 1200 1210 1220 1230
pF1KB0 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
1280 1290 1300 1310 1320 1330
1240 1250 1260 1270 1280 1290
pF1KB0 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
1340 1350 1360 1370 1380 1390
1300 1310 1320 1330 1340 1350
pF1KB0 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
1400 1410 1420 1430 1440 1450
1360 1370 1380 1390 1400 1410
pF1KB0 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPI
1460 1470 1480 1490 1500 1510
1420 1430 1440 1450 1460 1470
pF1KB0 QATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKP
1520 1530 1540 1550 1560 1570
1480 1490 1500 1510 1520 1530
pF1KB0 ATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERK
1580 1590 1600 1610 1620 1630
1540 1550 1560 1570 1580 1590
pF1KB0 FESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKY
1640 1650 1660 1670 1680 1690
1600 1610 1620 1630 1640 1650
pF1KB0 QINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGA
1700 1710 1720 1730 1740 1750
1660 1670 1680 1690 1700 1710
pF1KB0 IPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMT
1760 1770 1780 1790 1800 1810
1720 1730 1740 1750
pF1KB0 PDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
::: ::::::::::::::::::::::::::::::
XP_011 PDG-------------DPKTWQNKCLPGDPNYLVGANCVSVLIDHF
1820 1830 1840
>>NP_003248 (OMIM: 601009) tight junction protein ZO-1 i (1748 aa)
initn: 11694 init1: 11481 opt: 11487 Z-score: 5151.2 bits: 966.3 E(85289): 0
Smith-Waterman score: 11658; 98.9% identity (98.9% similar) in 1756 aa overlap (1-1756:13-1748)
10 20 30 40
pF1KB0 MEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL
::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB0 KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB0 PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB0 PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB0 SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB0 GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB0 DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB0 SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB0 EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB0 EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB0 FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB0 LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ
670 680 690 700 710 720
710 720 730 740 750 760
pF1KB0 WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND
730 740 750 760 770 780
770 780 790 800 810 820
pF1KB0 GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT
790 800 810 820 830 840
830 840 850 860 870 880
pF1KB0 SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP
850 860 870 880 890 900
890 900 910 920 930 940
pF1KB0 QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KB0 PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KB0 QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KB0 EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KB0 DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KB0 QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KB0 PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KB0 KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KB0 SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KB0 PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KB0 QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590 1600
pF1KB0 PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA
1570 1580 1590 1600 1610 1620
1610 1620 1630 1640 1650 1660
pF1KB0 VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS
1630 1640 1650 1660 1670 1680
1670 1680 1690 1700 1710 1720
pF1KB0 ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDP
:::::::::::::::::::::::::::::::::::::: ::
NP_003 ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHC--------------------DP
1690 1700 1710 1720
1730 1740 1750
pF1KB0 KTWQNKCLPGDPNYLVGANCVSVLIDHF
::::::::::::::::::::::::::::
NP_003 KTWQNKCLPGDPNYLVGANCVSVLIDHF
1730 1740
>>XP_005254674 (OMIM: 601009) PREDICTED: tight junction (1841 aa)
initn: 11694 init1: 11481 opt: 11487 Z-score: 5150.9 bits: 966.3 E(85289): 0
Smith-Waterman score: 11658; 98.9% identity (98.9% similar) in 1756 aa overlap (1-1756:106-1841)
10 20 30
pF1KB0 MEETAIWEQHTVTLHRAPGFGFGIAISGGR
::::::::::::::::::::::::::::::
XP_005 GKPSLRRIKGRLHRSKSLDSMDFCELTSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGR
80 90 100 110 120 130
40 50 60 70 80 90
pF1KB0 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
140 150 160 170 180 190
100 110 120 130 140 150
pF1KB0 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
200 210 220 230 240 250
160 170 180 190 200 210
pF1KB0 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
260 270 280 290 300 310
220 230 240 250 260 270
pF1KB0 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
320 330 340 350 360 370
280 290 300 310 320 330
pF1KB0 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
380 390 400 410 420 430
340 350 360 370 380 390
pF1KB0 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
440 450 460 470 480 490
400 410 420 430 440 450
pF1KB0 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
500 510 520 530 540 550
460 470 480 490 500 510
pF1KB0 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
560 570 580 590 600 610
520 530 540 550 560 570
pF1KB0 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
620 630 640 650 660 670
580 590 600 610 620 630
pF1KB0 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
680 690 700 710 720 730
640 650 660 670 680 690
pF1KB0 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
740 750 760 770 780 790
700 710 720 730 740 750
pF1KB0 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
800 810 820 830 840 850
760 770 780 790 800 810
pF1KB0 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
860 870 880 890 900 910
820 830 840 850 860 870
pF1KB0 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
920 930 940 950 960 970
880 890 900 910 920 930
pF1KB0 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
980 990 1000 1010 1020 1030
940 950 960 970 980 990
pF1KB0 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
1040 1050 1060 1070 1080 1090
1000 1010 1020 1030 1040 1050
pF1KB0 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
1100 1110 1120 1130 1140 1150
1060 1070 1080 1090 1100 1110
pF1KB0 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
1160 1170 1180 1190 1200 1210
1120 1130 1140 1150 1160 1170
pF1KB0 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
1220 1230 1240 1250 1260 1270
1180 1190 1200 1210 1220 1230
pF1KB0 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
1280 1290 1300 1310 1320 1330
1240 1250 1260 1270 1280 1290
pF1KB0 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
1340 1350 1360 1370 1380 1390
1300 1310 1320 1330 1340 1350
pF1KB0 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
1400 1410 1420 1430 1440 1450
1360 1370 1380 1390 1400 1410
pF1KB0 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPI
1460 1470 1480 1490 1500 1510
1420 1430 1440 1450 1460 1470
pF1KB0 QATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKP
1520 1530 1540 1550 1560 1570
1480 1490 1500 1510 1520 1530
pF1KB0 ATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERK
1580 1590 1600 1610 1620 1630
1540 1550 1560 1570 1580 1590
pF1KB0 FESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKY
1640 1650 1660 1670 1680 1690
1600 1610 1620 1630 1640 1650
pF1KB0 QINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGA
1700 1710 1720 1730 1740 1750
1660 1670 1680 1690 1700 1710
pF1KB0 IPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHC----
1760 1770 1780 1790 1800 1810
1720 1730 1740 1750
pF1KB0 PDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
::::::::::::::::::::::::::::::
XP_005 ----------------DPKTWQNKCLPGDPNYLVGANCVSVLIDHF
1820 1830 1840
>>XP_016878011 (OMIM: 601009) PREDICTED: tight junction (1865 aa)
initn: 11515 init1: 9324 opt: 9532 Z-score: 4277.1 bits: 804.6 E(85289): 0
Smith-Waterman score: 11676; 98.3% identity (98.3% similar) in 1773 aa overlap (1-1756:106-1865)
10 20 30
pF1KB0 MEETAIWEQHTVTLHRAPGFGFGIAISGGR
::::::::::::::::::::::::::::::
XP_016 GKPSLRRIKGRLHRSKSLDSMDFCELTSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGR
80 90 100 110 120 130
40 50 60 70 80 90
pF1KB0 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
140 150 160 170 180 190
100 110 120 130 140 150
pF1KB0 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
200 210 220 230 240 250
160 170 180 190 200 210
pF1KB0 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
260 270 280 290 300 310
220 230 240 250 260 270
pF1KB0 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
320 330 340 350 360 370
280 290 300 310 320 330
pF1KB0 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
380 390 400 410 420 430
340 350 360 370 380 390
pF1KB0 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
440 450 460 470 480 490
400 410 420 430 440 450
pF1KB0 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
500 510 520 530 540 550
460 470 480 490 500 510
pF1KB0 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
560 570 580 590 600 610
520 530 540 550 560 570
pF1KB0 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
620 630 640 650 660 670
580 590 600 610 620 630
pF1KB0 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
680 690 700 710 720 730
640 650 660 670 680 690
pF1KB0 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
740 750 760 770 780 790
700 710 720 730 740 750
pF1KB0 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
800 810 820 830 840 850
760 770 780 790 800 810
pF1KB0 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
860 870 880 890 900 910
820 830 840 850 860 870
pF1KB0 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
920 930 940 950 960 970
880 890 900 910 920 930
pF1KB0 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
980 990 1000 1010 1020 1030
940 950 960 970 980 990
pF1KB0 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
1040 1050 1060 1070 1080 1090
1000 1010 1020 1030 1040 1050
pF1KB0 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
1100 1110 1120 1130 1140 1150
1060 1070 1080 1090 1100 1110
pF1KB0 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
1160 1170 1180 1190 1200 1210
1120 1130 1140 1150 1160 1170
pF1KB0 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
1220 1230 1240 1250 1260 1270
1180 1190 1200 1210 1220 1230
pF1KB0 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
1280 1290 1300 1310 1320 1330
1240 1250 1260 1270 1280 1290
pF1KB0 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
1340 1350 1360 1370 1380 1390
1300 1310 1320 1330 1340 1350
pF1KB0 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
1400 1410 1420 1430 1440 1450
1360 1370 1380 1390
pF1KB0 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSK-----------------GKPP
::::::::::::::::::::::::::::::::::::::: ::::
XP_016 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKFLGSYTSYDYLKRNVKWGKPP
1460 1470 1480 1490 1500 1510
1400 1410 1420 1430 1440 1450
pF1KB0 EADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDF
1520 1530 1540 1550 1560 1570
1460 1470 1480 1490 1500 1510
pF1KB0 QNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYN
1580 1590 1600 1610 1620 1630
1520 1530 1540 1550 1560 1570
pF1KB0 RFTPKPYTSSARPFERKFESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFTPKPYTSSARPFERKFESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPE
1640 1650 1660 1670 1680 1690
1580 1590 1600 1610 1620 1630
pF1KB0 FDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGG
1700 1710 1720 1730 1740 1750
1640 1650 1660 1670 1680 1690
pF1KB0 VLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGL
1760 1770 1780 1790 1800 1810
1700 1710 1720 1730 1740 1750
pF1KB0 KFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLI
:::::::::::::::::::: :::::::::::::::::::::::::::
XP_016 KFLKPVELRLPHCASMTPDG-------------DPKTWQNKCLPGDPNYLVGANCVSVLI
1820 1830 1840 1850 1860
pF1KB0 DHF
:::
XP_016 DHF
>>XP_016878012 (OMIM: 601009) PREDICTED: tight junction (1858 aa)
initn: 11680 init1: 9324 opt: 9508 Z-score: 4266.4 bits: 802.6 E(85289): 0
Smith-Waterman score: 11614; 97.9% identity (97.9% similar) in 1773 aa overlap (1-1756:106-1858)
10 20 30
pF1KB0 MEETAIWEQHTVTLHRAPGFGFGIAISGGR
::::::::::::::::::::::::::::::
XP_016 GKPSLRRIKGRLHRSKSLDSMDFCELTSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGR
80 90 100 110 120 130
40 50 60 70 80 90
pF1KB0 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
140 150 160 170 180 190
100 110 120 130 140 150
pF1KB0 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
200 210 220 230 240 250
160 170 180 190 200 210
pF1KB0 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
260 270 280 290 300 310
220 230 240 250 260 270
pF1KB0 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
320 330 340 350 360 370
280 290 300 310 320 330
pF1KB0 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
380 390 400 410 420 430
340 350 360 370 380 390
pF1KB0 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
440 450 460 470 480 490
400 410 420 430 440 450
pF1KB0 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
500 510 520 530 540 550
460 470 480 490 500 510
pF1KB0 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
560 570 580 590 600 610
520 530 540 550 560 570
pF1KB0 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
620 630 640 650 660 670
580 590 600 610 620 630
pF1KB0 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
680 690 700 710 720 730
640 650 660 670 680 690
pF1KB0 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
740 750 760 770 780 790
700 710 720 730 740 750
pF1KB0 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
800 810 820 830 840 850
760 770 780 790 800 810
pF1KB0 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
860 870 880 890 900 910
820 830 840 850 860 870
pF1KB0 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
920 930 940 950 960 970
880 890 900 910 920 930
pF1KB0 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
980 990 1000 1010 1020 1030
940 950 960 970 980 990
pF1KB0 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
1040 1050 1060 1070 1080 1090
1000 1010 1020 1030 1040 1050
pF1KB0 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
1100 1110 1120 1130 1140 1150
1060 1070 1080 1090 1100 1110
pF1KB0 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
1160 1170 1180 1190 1200 1210
1120 1130 1140 1150 1160 1170
pF1KB0 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
1220 1230 1240 1250 1260 1270
1180 1190 1200 1210 1220 1230
pF1KB0 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
1280 1290 1300 1310 1320 1330
1240 1250 1260 1270 1280 1290
pF1KB0 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
1340 1350 1360 1370 1380 1390
1300 1310 1320 1330 1340 1350
pF1KB0 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
1400 1410 1420 1430 1440 1450
1360 1370 1380 1390
pF1KB0 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSK-----------------GKPP
::::::::::::::::::::::::::::::::::::::: ::::
XP_016 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKFLGSYTSYDYLKRNVKWGKPP
1460 1470 1480 1490 1500 1510
1400 1410 1420 1430 1440 1450
pF1KB0 EADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDF
1520 1530 1540 1550 1560 1570
1460 1470 1480 1490 1500 1510
pF1KB0 QNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYN
1580 1590 1600 1610 1620 1630
1520 1530 1540 1550 1560 1570
pF1KB0 RFTPKPYTSSARPFERKFESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFTPKPYTSSARPFERKFESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPE
1640 1650 1660 1670 1680 1690
1580 1590 1600 1610 1620 1630
pF1KB0 FDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGG
1700 1710 1720 1730 1740 1750
1640 1650 1660 1670 1680 1690
pF1KB0 VLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGL
1760 1770 1780 1790 1800 1810
1700 1710 1720 1730 1740 1750
pF1KB0 KFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLI
::::::::::::: :::::::::::::::::::::::::::
XP_016 KFLKPVELRLPHC--------------------DPKTWQNKCLPGDPNYLVGANCVSVLI
1820 1830 1840 1850
pF1KB0 DHF
:::
XP_016 DHF
>>XP_016878016 (OMIM: 601009) PREDICTED: tight junction (1783 aa)
initn: 11827 init1: 9324 opt: 9336 Z-score: 4189.8 bits: 788.4 E(85289): 0
Smith-Waterman score: 11797; 99.0% identity (99.0% similar) in 1773 aa overlap (1-1756:11-1783)
10 20 30 40 50
pF1KB0 MEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKG
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLYYLFKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKG
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB0 GPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB0 PVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPA
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB0 KPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSL
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB0 TDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGR
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB0 SHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDH
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB0 TPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSM
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB0 KLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREE
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB0 AVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEV
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB0 FRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFW
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB0 RFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLA
610 620 630 640 650 660
660 670 680 690 700 710
pF1KB0 REEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWY
670 680 690 700 710 720
720 730 740 750 760 770
pF1KB0 PIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGW
730 740 750 760 770 780
780 790 800 810 820 830
pF1KB0 YGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSD
790 800 810 820 830 840
840 850 860 870 880 890
pF1KB0 YEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQA
850 860 870 880 890 900
900 910 920 930 940 950
pF1KB0 QPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPTPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPTPA
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KB0 PSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLKQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLKQP
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KB0 AVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRYED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRYED
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KB0 RVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSYDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSYDS
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KB0 RPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYEQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYEQV
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KB0 PPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMKPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMKPQ
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KB0 SVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHDKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHDKT
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KB0 LYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHLSE
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410
pF1KB0 PAKPAHSQNQSNFSSYSSK-----------------GKPPEADGVDRSFGEKRYEPIQAT
::::::::::::::::::: ::::::::::::::::::::::::
XP_016 PAKPAHSQNQSNFSSYSSKFLGSYTSYDYLKRNVKWGKPPEADGVDRSFGEKRYEPIQAT
1390 1400 1410 1420 1430 1440
1420 1430 1440 1450 1460 1470
pF1KB0 PPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATF
1450 1460 1470 1480 1490 1500
1480 1490 1500 1510 1520 1530
pF1KB0 RPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFES
1510 1520 1530 1540 1550 1560
1540 1550 1560 1570 1580 1590
pF1KB0 PKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQIN
1570 1580 1590 1600 1610 1620
1600 1610 1620 1630 1640 1650
pF1KB0 NISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPE
1630 1640 1650 1660 1670 1680
1660 1670 1680 1690 1700 1710
pF1KB0 GVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDG
1690 1700 1710 1720 1730 1740
1720 1730 1740 1750
pF1KB0 WSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
:::::::::::::::::::::::::::::::::::::::::::
XP_016 WSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
1750 1760 1770 1780
1756 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 22:34:27 2016 done: Wed Nov 2 22:34:30 2016
Total Scan time: 18.820 Total Display time: 1.310
Function used was FASTA [36.3.4 Apr, 2011]