FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0056, 1533 aa 1>>>pF1KB0056 1533 - 1533 aa - 1533 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 14.4004+/-0.00121; mu= -13.4840+/- 0.073 mean_var=693.3168+/-144.572, 0's: 0 Z-trim(117.8): 107 B-trim: 189 in 1/54 Lambda= 0.048709 statistics sampled from 18568 (18671) to 18568 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.805), E-opt: 0.2 (0.574), width: 16 Scan time: 8.320 The best scores are: opt bits E(32554) CCDS4708.1 PRRC2A gene_id:7916|Hs108|chr6 (2157) 6038 440.8 2.2e-122 CCDS1296.2 PRRC2C gene_id:23215|Hs108|chr1 (2817) 1171 98.9 2.4e-19 CCDS48044.1 PRRC2B gene_id:84726|Hs108|chr9 (2229) 894 79.3 1.5e-13 >>CCDS4708.1 PRRC2A gene_id:7916|Hs108|chr6 (2157 aa) initn: 6028 init1: 5978 opt: 6038 Z-score: 2310.6 bits: 440.8 E(32554): 2.2e-122 Smith-Waterman score: 6158; 63.8% identity (72.2% similar) in 1565 aa overlap (1-1532:1-1454) 10 20 30 40 50 60 pF1KB0 MSDRSGPTAKGKDGKKYSSLNLFDTYKGKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 MSDRSGPTAKGKDGKKYSSLNLFDTYKGKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 NLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPLESQPLPASQTPASN ::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::: CCDS47 NLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 QPKRPPAAPENTPLVPSGVKSWAQASVTHGAHGDGGRASSLLSRFSREEFPTLQAAGDQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 QPKRPPAAPENTPLVPSGVKSWAQASVTHGAHGDGGRASSLLSRFSREEFPTLQAAGDQD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 KAAKERESAEQSSGPGPSLRPQNSTTWRDGGGRGPDELEGPDSKLHHGHDPRGGLQPSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 KAAKERESAEQSSGPGPSLRPQNSTTWRDGGGRGPDELEGPDSKLHHGHDPRGGLQPSGP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 PQFPPYRGMMPPFMYPPYLPFPPPYGPQGPYRYPTPDGPSRFPRVAGPRGSGPPMRLVEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 PQFPPYRGMMPPFMYPPYLPFPPPYGPQGPYRYPTPDGPSRFPRVAGPRGSGPPMRLVEP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 VGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 VGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHRD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 SQSASGEERPPEADGKKGNSPNSEPPTPKTAWAETSRPPETEPGPPAPKPPLPPPHRGPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 SQSASGEERPPEADGKKGNSPNSEPPTPKTAWAETSRPPETEPGPPAPKPPLPPPHRGPA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 GNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 GNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB0 ERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPKELPAPPAPPPASAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 ERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPKELPAPPAPPPASAP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB0 TPEKEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPE ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 TPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB0 PPEEVPPPTTPPVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 PPEEVPPPTTPPVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB0 QHQWQQHQQGSAPPTPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 QHQWQQHQQGSAPPTPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB0 PRWMMIPPYVDPRLLQGRPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFDRHAPAMLRER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 PRWMMIPPYVDPRLLQGRPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFDRHAPAMLRER 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB0 GTPPVDPKLAWVGDVFTATPAEPRPLTSPLRQAADEDDKGMRSETPPVPPPPPSSSAVFR ::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 GTPPVDPKLAWVGDVFTATPAEPRPLTSPLRQAADEDDKGMRSETPPVPPPPP------- 790 800 810 820 830 850 860 870 880 890 pF1KB0 LDQVIHSNPAGIQQALAQLSSRQGSVTAPGGHPRHKPGPPQAPQ-GPSPRPPTRYEPQRV . : :. ... . . :: :: : :: . . . :: . :: . CCDS47 ---YLASYPGFPENGAPGPPISRFPLEEPG--PRPLPWPPGSDEVAKIQTPPPKKEPPKE 840 850 860 870 880 900 910 920 930 940 950 pF1KB0 NSGLSSDPHFEEPGPMVRGVGGTPRDSAGVSPFPPKRRERPPRKPELLQEESLPPPHSSG ... . : : .:::: :.: .: ::.:. : : : .:. CCDS47 ETAQLTGP--EAGRKPARGVG-----SGGQGPPPPRRESRT--------ETRWGPRPGSS 890 900 910 920 930 960 970 980 990 1000 1010 pF1KB0 FLGSKPEGPGPQAESRDTGTEALTPHIWNRLHTATSRKSYRPSSMEPWMEPLSPFEDVAG : :: :: : : .: : .: :...: : .:.:. : CCDS47 RRGIPPEEPG--APPRRAG-----P----------IKKPPPPTKVEEL--PPKPLEQ--G 940 950 960 970 1020 1030 1040 1050 1060 1070 pF1KB0 TEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRPGGSSPLNAVPCEGPP- : . . :. . .:: ... :.:.:. : . .: . .. . :.: CCDS47 DETPKPPKPDPLKITKGKLGGP--KETPPNGNLSPAPR--LRRDYSYERVGPTSCRGRGR 980 990 1000 1010 1020 1080 1090 1100 1110 1120 1130 pF1KB0 GSEPPRRPPPAPHDGDRKELPREQPLPPGPIGTERSQRTDRGTEPGPIRPSHRPGPPVQF : : : : . : . . . : : : : : :.: ::. CCDS47 GEYFARGRGFRGTYGGRGRGARSREFR-----SYREFRGDDGRGGGTGGPNH---PPAPR 1030 1040 1050 1060 1070 1080 1140 1150 1160 1170 1180 1190 pF1KB0 GTSDKDSDLRLVVGDSLKAEKELTASVTEAIPVSRDWELLPSAAASAEPQSKNLDSGHCV : . :. : .. . :. .:. ... .: :: . :. .: . . CCDS47 GRT--ASETRSEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKEAPTPKEGTLTQVPLA 1090 1100 1110 1120 1130 1200 1210 1220 1230 1240 1250 pF1KB0 PEPSSSGQRLYPEVFYGSAG--------PSSSQISGGAMDSQLHPNSGGFRPGTPSLHPY : : .. : : . .: :: .:: :. : :. : . :: : CCDS47 PPPPGAPPSPAPARFTARGGRVFTPRGVPSRRGRGGGRPPPQVCP---GWSPPAKSLAP- 1140 1150 1160 1170 1180 1190 1260 1270 1280 1290 1300 pF1KB0 RSQPLYLPPGPAPPSALLSGVALKGQFLDFSTMQATELGKLPAGGVLYP----PPSFLYS ..: : :: ::: :: ... ... :. ...: . : .. CCDS47 -KKP---PTGPLPPSKE----PLKEKLIPGPLSPVARGGSNGGSNVGMEDGERPRRRRHG 1200 1210 1220 1230 1240 1310 1320 1330 1340 1350 1360 pF1KB0 PAFCPSPLPD-TSLLQVRQDLPSPSDFYSTPLQPGGQSGFLPSGAPAQQMLLPMVDSQLP : . : : : :.. :. : : ::..::. . : : CCDS47 RAQQQDKPPRFRRLKQERENAARGSE--------GKPSLTLPASAPGPEEALTTV----- 1250 1260 1270 1280 1290 1370 1380 1390 1400 1410 1420 pF1KB0 VVNFGSLPPAPPPAP---PPLSLLPVGPALQPPSLAVRPPPAPATRVLPSPARPFPASLG .. ::: : : :: : . : . . : . : : CCDS47 -----TVAPAPRRAAAKSPDLSNQNSDQANEEWETASESSDFTSERRGDKEAPP------ 1300 1310 1320 1330 1340 1430 1440 1450 1460 1470 1480 pF1KB0 RAELHPVELKPFQDYQKLSSNLGGPGSSRTPP-TGRSFSGLNSRLKATPSTYSGVFRTQR :: : : : .. :: :.. .: .. : . :..: : : : : .:: CCDS47 -----PVLLTP-----KAVGTPGGGGGGAVPGISAMSRGDLSQRAKDL-SKRS--FSSQR 1350 1360 1370 1380 1490 1500 1510 1520 pF1KB0 VDLYQQASPPDALRWIPKPWERTG-----PPPREGPSRRAEE----PGSRG----DKEPG . .: : . .: : : ::.: .. : .:. .. :: CCDS47 PGMERQNRRPGPGGKAGSSGSSSGGGGGGPGGRTGPGRGDKRSWPSPKNRSRPPEERPPG 1390 1400 1410 1420 1430 1440 1530 pF1KB0 LP-PPR :: :: CCDS47 LPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSVTAPGGHPRHKPGLPQAPQG 1450 1460 1470 1480 1490 1500 >-- initn: 4960 init1: 4960 opt: 4960 Z-score: 1901.2 bits: 365.0 E(32554): 1.4e-99 Smith-Waterman score: 4960; 99.7% identity (99.9% similar) in 703 aa overlap (831-1533:1455-2157) 810 820 830 840 850 860 pF1KB0 AEPRPLTSPLRQAADEDDKGMRSETPPVPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLS :::::::::::::::::::::::::::::: CCDS47 PGRGDKRSWPSPKNRSRPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLS 1430 1440 1450 1460 1470 1480 870 880 890 900 910 920 pF1KB0 SRQGSVTAPGGHPRHKPGPPQAPQGPSPRPPTRYEPQRVNSGLSSDPHFEEPGPMVRGVG :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: CCDS47 SRQGSVTAPGGHPRHKPGLPQAPQGPSPRPPTRYEPQRVNSGLSSDPHFEEPGPMVRGVG 1490 1500 1510 1520 1530 1540 930 940 950 960 970 980 pF1KB0 GTPRDSAGVSPFPPKRRERPPRKPELLQEESLPPPHSSGFLGSKPEGPGPQAESRDTGTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 GTPRDSAGVSPFPPKRRERPPRKPELLQEESLPPPHSSGFLGSKPEGPGPQAESRDTGTE 1550 1560 1570 1580 1590 1600 990 1000 1010 1020 1030 1040 pF1KB0 ALTPHIWNRLHTATSRKSYRPSSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 ALTPHIWNRLHTATSRKSYRPSSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSG 1610 1620 1630 1640 1650 1660 1050 1060 1070 1080 1090 1100 pF1KB0 PCSQRSSPDGGLKGAAEGPPKRPGGSSPLNAVPCEGPPGSEPPRRPPPAPHDGDRKELPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 PCSQRSSPDGGLKGAAEGPPKRPGGSSPLNAVPCEGPPGSEPPRRPPPAPHDGDRKELPR 1670 1680 1690 1700 1710 1720 1110 1120 1130 1140 1150 1160 pF1KB0 EQPLPPGPIGTERSQRTDRGTEPGPIRPSHRPGPPVQFGTSDKDSDLRLVVGDSLKAEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 EQPLPPGPIGTERSQRTDRGTEPGPIRPSHRPGPPVQFGTSDKDSDLRLVVGDSLKAEKE 1730 1740 1750 1760 1770 1780 1170 1180 1190 1200 1210 1220 pF1KB0 LTASVTEAIPVSRDWELLPSAAASAEPQSKNLDSGHCVPEPSSSGQRLYPEVFYGSAGPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 LTASVTEAIPVSRDWELLPSAAASAEPQSKNLDSGHCVPEPSSSGQRLYPEVFYGSAGPS 1790 1800 1810 1820 1830 1840 1230 1240 1250 1260 1270 1280 pF1KB0 SSQISGGAMDSQLHPNSGGFRPGTPSLHPYRSQPLYLPPGPAPPSALLSGVALKGQFLDF ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: CCDS47 SSQISGGAMDSQLHPNSGGFRPGTPSLHPYRSQPLYLPPGPAPPSALLSGLALKGQFLDF 1850 1860 1870 1880 1890 1900 1290 1300 1310 1320 1330 1340 pF1KB0 STMQATELGKLPAGGVLYPPPSFLYSPAFCPSPLPDTSLLQVRQDLPSPSDFYSTPLQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 STMQATELGKLPAGGVLYPPPSFLYSPAFCPSPLPDTSLLQVRQDLPSPSDFYSTPLQPG 1910 1920 1930 1940 1950 1960 1350 1360 1370 1380 1390 1400 pF1KB0 GQSGFLPSGAPAQQMLLPMVDSQLPVVNFGSLPPAPPPAPPPLSLLPVGPALQPPSLAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 GQSGFLPSGAPAQQMLLPMVDSQLPVVNFGSLPPAPPPAPPPLSLLPVGPALQPPSLAVR 1970 1980 1990 2000 2010 2020 1410 1420 1430 1440 1450 1460 pF1KB0 PPPAPATRVLPSPARPFPASLGRAELHPVELKPFQDYQKLSSNLGGPGSSRTPPTGRSFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 PPPAPATRVLPSPARPFPASLGRAELHPVELKPFQDYQKLSSNLGGPGSSRTPPTGRSFS 2030 2040 2050 2060 2070 2080 1470 1480 1490 1500 1510 1520 pF1KB0 GLNSRLKATPSTYSGVFRTQRVDLYQQASPPDALRWIPKPWERTGPPPREGPSRRAEEPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 GLNSRLKATPSTYSGVFRTQRVDLYQQASPPDALRWIPKPWERTGPPPREGPSRRAEEPG 2090 2100 2110 2120 2130 2140 1530 pF1KB0 SRGDKEPGLPPPR ::::::::::::: CCDS47 SRGDKEPGLPPPR 2150 >>CCDS1296.2 PRRC2C gene_id:23215|Hs108|chr1 (2817 aa) initn: 1214 init1: 344 opt: 1171 Z-score: 460.7 bits: 98.9 E(32554): 2.4e-19 Smith-Waterman score: 1819; 30.5% identity (52.0% similar) in 1674 aa overlap (1-1533:1-1562) 10 20 30 40 50 60 pF1KB0 MSDRSGPTAKGKDGKKYSSLNLFDTYKGKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPA ::..:: ..:.::::::..:.::.:::::::: :: .. ::::::::::.:.::::::: CCDS12 MSEKSGQSTKAKDGKKYATLSLFNTYKGKSLETQKTTA--RHGLQSLGKVGISRRMPPPA 10 20 30 40 50 70 80 90 100 110 120 pF1KB0 NLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPLESQPLPASQTPASN ::::::::::::::::..:::::::::::::: . . .. .: :: CCDS12 NLPSLKAENKGNDPNVNIVPKDGTGWASKQEQHEEE----------KTPEVP----PA-- 60 70 80 90 100 130 140 150 160 170 180 pF1KB0 QPKRPPAAPENTPLVPSGVKSWAQASVTHGAHGDGGRASSLLSRFSREEFPTLQAAGDQD ::: ::: : : . :::: : .:..::: ...: . ..:::.:::::::. CCDS12 QPKPGVAAP---PEVAPAPKSWA--SNKQGGQGDGIQVNSQF----QQEFPSLQAAGDQE 110 120 130 140 150 190 200 210 220 230 pF1KB0 KAAKERESAEQSSGPGPSLRPQNSTTWRDGG-GRGPDELEGPDSKLHHGHDPRGGLQPS- : ::.:. ... :::::::: : . ::::: . : : :: . .: . . CCDS12 K--KEKETNDDNYGPGPSLRPPNVACWRDGGKAAGSPSSSDQDEKLPGQDESTAGTSEQN 160 170 180 190 200 210 240 250 260 270 pF1KB0 ------------GPPQFP----------PYRGMMPPFMYP--PYLPFPPPYGPQGPYRYP :::: ::.::::.:. : . .:: .::. :.: CCDS12 DILKVVEKRIACGPPQAKLNGQQAALASQYRAMMPPYMFQQYPRMTYPPLHGPM---RFP 220 230 240 250 260 280 290 300 310 320 330 pF1KB0 TPDGPSRFPRVAGPRGSGPPMRLVEPVGRPSILKEDNLKE---FDQLDQENDDGWAGAHE :: : :: ::: . :::::. ..::: ::.:: : :.:::::. CCDS12 ----PSLSETNKGLRGRGPPPSWASEPERPSILSASELKELDKFDNLDAEADEGWAGAQM 270 280 290 300 310 320 340 350 360 370 380 pF1KB0 EVDYTEKLKFSDE-EDGRDSDEEGAEGHRDSQSASGEERPPEADGKKGNSPNSE-PPTPK ::::::.:.:::. :.: .: .:. . :... ..: :.: .... .:. : :. CCDS12 EVDYTEQLNFSDDDEQGSNSPKENNSEDQGSKASENNENKKETDEVSNTKSSSQIPAQPS 330 340 350 360 370 380 390 400 410 420 430 440 pF1KB0 TAWAETSRPP--ETEPGPPAPKPPLPPPHRGPAGNWGPPGDY--PDRGGP-PCKPPAPED .: . .. : . : : . :::: . : . :: : : :: : : . : CCDS12 VAKVPYGKGPSFNQERGTSSH---LPPPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVA-D 390 400 410 420 430 440 450 460 470 480 490 500 pF1KB0 EDEAWRQRRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRL ::: :.:::.:.: ::: ::::::.:::::::::.:.:.:::::::::::::.: .:. CCDS12 EDEIWKQRRRQQS-EISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQP 450 460 470 480 490 510 520 530 540 550 560 pF1KB0 KAEPAAPPAAPSTPAPPPAVPKELPAPPAPPPAS--APTPEKEPE-EPAQAPPAQSTPTP . : . . :: . ::: : : : . CCDS12 SPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKER 500 510 520 530 540 550 570 580 590 600 pF1KB0 GVAAAPTLVSGGGSTSSTSSGSFEAS----------------PVEPQL-PSKEGPEPP-- : . . .. . . . : ::.: : : : CCDS12 KQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESENS 560 570 580 590 600 610 610 620 630 640 pF1KB0 ---EEVPPPT-----------TPPVPKVEPKGDGIGPTRQP-PSQGLGYPK-YQKSLPPR :: : : :: : ..::.. . :: :. :: : .::::::: CCDS12 CNKEEEPVFTRQDSNRSEKEATPVVHETEPESGS-----QPRPAVLSGYFKQFQKSLPPR 620 630 640 650 660 670 650 660 670 680 690 700 pF1KB0 FQRQQQEQLLKQQQQHQWQQHQQGSAPPTPVPPSPPQPVTLGAVPAPQAPPPPPKALYPG :::::. :..:.::::.:: .. : :: .: . . .:::: . :: CCDS12 FQRQQE-----QMKQQQWQQQQQQGVLPQTVPSQPSSST---------VPPPPHRPLYQP 680 690 700 710 720 710 720 730 740 750 760 pF1KB0 ALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRPPLDFYP--PG-VHPSGLVPRERSDSGG .: . :.:::::.:. :.:::...::: .:. : :: . :. :. :.. ... CCDS12 MQPHPQHLASMGFDPRWLMMQSYMDPRMMSGRPAMDIPPIHPGMIPPKPLMRRDQMEGSP 730 740 750 760 770 780 770 780 790 800 810 820 pF1KB0 SSSEPFDRHAPAMLRERGTPPVDPKLAWVGDVFTATPAEPRPLTSPLRQAADEDDKGMRS .::: :. : :... .:.. : .: . :::. :.: : :. . .:: CCDS12 NSSESFE-HIARSARDHAISLSEPRMLWGSDPYPH--AEPQQATTP---KATEEPEDVRS 790 800 810 820 830 830 840 850 860 870 880 pF1KB0 ETPPVPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSVTAPGGHPRHKPGPPQAP :. .. .: . . : . :... .. : .. .:.: . :. CCDS12 EAALDQEQITAAYSVEHNQLEAHPKADFIRESSEAQVQKFLSRSVEDVRPHHTDANNQSA 840 850 860 870 880 890 890 900 910 920 930 pF1KB0 QGPSPRPPTRYEPQ--RVNSGLSSDPHFEEPGPMVRGVGGTPR-DSAGVSPFP--PKRRE .: : :: :. :.. :.: .. . .: . : . : : :: CCDS12 CFEAPDQKTLSAPQEERI-SAVESQPSRKRS--VSHGSNHTQKPDEQRSEPSAGIPKVTS 900 910 920 930 940 950 940 950 960 970 980 990 pF1KB0 R--PPRKPELLQEESLPPPHSSGFLGSKPEGPGPQAESRDTGTEALTPHIW-NRLHTATS : ..: ::. :.. ::. :. ::: :. .. . :. :: . ... CCDS12 RCIDSKEPIERPEEK---PKKEGFIRSS-EGPKPEKVYKSKSETRWGPRPSSNRREEVND 960 970 980 990 1000 1000 1010 1020 1030 1040 1050 pF1KB0 RKSYRPSSME-PWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKG : : . .. : .. .. :. . ...... .. :. ... : CCDS12 RPVRRSGPIKKPVLRDMK--EEREQRKEKEGEKAEKVTEKVVVKPEKTEKKDLPP----- 1010 1020 1030 1040 1050 1060 1060 1070 1080 1090 1100 1110 pF1KB0 AAEGPPKRPGGSSPLNAVPCEGPPGSEPPRRPPPAPHDGDRKELPR---EQPLPP-GPIG :: : .:.. : :: .: . :. . . . : :.:: : . . CCDS12 ----PPPPPQPPAPIQ--PQSVPPPIQPEAEKFPSTETATLAQKPSQDTEKPLEPVSTVQ 1070 1080 1090 1100 1110 1120 1130 1140 1150 1160 pF1KB0 TERSQRT-DRGTEPGPI-RPSHRPGPPVQFGTSDKDSDLRLVVGDS---LKAEKELTASV .: . .: .. : .:. . ..: .. :: .. :: .: :. : . CCDS12 VEPAVKTVNQQTMAAPVVKEEKQPEKVIS-----KDLVIERPRPDSRPAVKKESTLPPRT 1120 1130 1140 1150 1160 1170 1180 1190 1200 1210 pF1KB0 TEAIPVSRDWELLPSAAASAEPQSKNLDSGHCVPEPSSSGQ--------RLYPEVFYGSA ::: .:. . .. ... . :. . : .:. : ::. : . CCDS12 YWKEARERDW--FPDQGYRGRGRGEYYSRGRSY-RGSYGGRGRGGRGHTRDYPQ--YRDN 1170 1180 1190 1200 1210 1220 1220 1230 1240 1250 1260 1270 pF1KB0 GPSSSQISGGAM----DSQLHPNSGGFRPGTPSLHPYRSQPLYLPPGPAPPSALLSGVAL : . .: .: . .:. . .:. :. .:. . :.. . :: . CCDS12 KPRAEHIPSGPLRQREESETRSESSDFEV-VPKRRRQRGSETDTD-SEIHESASDKDSLS 1230 1240 1250 1260 1270 1280 1280 1290 1300 1310 1320 1330 pF1KB0 KGQFLDFSTMQATELGKLPAGGVLYPPPSFLYSPAFCPSPLPDTSLLQ---VRQDLPSPS ::.. . .: : . : :: .: :. ::. ::.: . CCDS12 KGKL---PKREERPENKKP----VKPHSSF--KPD--NHVRIDNRLLEKPYVRDDDKAKP 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KB0 DFY--STPLQPG-G----QSGFLPSGAPAQQMLL--PMV-DSQLPVVNFGSLPPAPPPAP : . : . : : ..: :.: :.. : : :.: . : : : . CCDS12 GFLPKGEPTRRGRGGTFRRGGRDPGGRPSRPSTLRRPAYRDNQWNPRQ--SEVPKPEDGE 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 pF1KB0 PPL---SLLPVGPALQPPSLAVRPPPAPATRVLPSPARPF----PASLGRAELHPVELK- :: ...:.. .::.. . :: :.:: : . : . . . : CCDS12 PPRRHEQFIPIAADKRPPKFERKFDPARERPRRQRPTRPPRQDKPPRFRRLREREAASKS 1390 1400 1410 1420 1430 1440 1440 1450 1460 1470 1480 pF1KB0 ------PFQDY-----QKLSSNLGGPGSSRTPPTGRSFSGLNSRLKATPSTYSGVFRTQR : . :. ..:: ....:: . . :. .. . .. :. : .: CCDS12 NEVVAVPTNGTVNNVAQEPVNTLGDISGNKTPDLSNQNSSDQANEEWETASESSDFNERR 1450 1460 1470 1480 1490 1500 1490 1500 1510 1520 1530 pF1KB0 VDLYQQASPPDALRWIPKPWERTGPPPREGPSRR--AEEPGSRGDKEPGLPPPR .. . .: . . : : . :: :: .: ...: .: ... . ::. CCDS12 ERDEKKNADLNA-QTVVKVGENVLPPKREIAKRSFSSQRPVDRQNRRGNNGPPKSGRNFS 1510 1520 1530 1540 1550 1560 CCDS12 GPRNERRSGPPSKSGKRGPFDDQPAGTTGVDLINGSSAHHQEGVPNGTGQKNSKDSTGKK 1570 1580 1590 1600 1610 1620 >>CCDS48044.1 PRRC2B gene_id:84726|Hs108|chr9 (2229 aa) initn: 1423 init1: 521 opt: 894 Z-score: 356.8 bits: 79.3 E(32554): 1.5e-13 Smith-Waterman score: 1763; 37.3% identity (55.1% similar) in 1055 aa overlap (1-978:1-940) 10 20 30 40 50 pF1KB0 MSDRSGPTAKGKDGK-KYSSLNLFDTYKGKSLEIQKPAVAPRHGLQSLGKVAIARRMPPP :::: : .:::::: :::.:.::: :::::.. . .: :::::::::::: ::::::: CCDS48 MSDRLGQITKGKDGKSKYSTLSLFDKYKGKSVDAIRSSVIPRHGLQSLGKVAAARRMPPP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB0 ANLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPLESQPLPASQTPAS :::::::.::::::::. .:::::::::.::.:.:::::.:...:: :: : :. : .: CCDS48 ANLPSLKSENKGNDPNIVIVPKDGTGWANKQDQQDPKSSSATASQPPESLPQPGLQKSVS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB0 N-QPKRPPAAPENTPLVPSGVKSWAQASVTHGAHGDGGRASSLLSRFSREEFPTLQAAGD : : . ::: ::.: ::::: . .: : :.:: : :: ::::::.::: CCDS48 NLQKPTQSISQENTNSVPGGPKSWAQLNGKPVGHEGGLRGSSRLLSFSPEEFPTLKAAGG 130 140 150 160 170 180 180 190 200 210 220 pF1KB0 QDKAAKERESAEQSSGPGPSLRPQNSTTWRDGGGR----------GPDELEGPDSKLHHG ::::.::. . : :::::::::: :.::.:::: .: :: . .:. : CCDS48 QDKAGKEKGVLDLSYGPGPSLRPQNVTSWREGGGRHIISATSLSTSPTELGSRNSSTGDG 190 200 210 220 230 240 230 240 250 260 pF1KB0 ----------HDPRGGLQPSGP-----PQF------PP-YRGMMPPFMYPPYLP------ .:: .:.:. : :: :: :. :.: :: : CCDS48 APSSACTSDSKDP--SLRPAQPVRKGASQFMGNVYHPPTYHDMLPAFMCSPKSSENQGTV 250 260 270 280 290 270 280 290 300 310 pF1KB0 ----FPPPY---GPQGPYR-YPTPDGPSRFPRVAGPRGSGPPMRLVEPVGRPSILKEDNL :: : :. :.: . : .. :.. : : .::: . ::.:.. .:: CCDS48 ERGSFPLPQLRLEPRVPFRQFQMNDQDGKENRLGLSRPLRPLRQLVERAPRPTIINAENL 300 310 320 330 340 350 320 330 340 350 360 370 pF1KB0 KEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHRDSQSASGEERPPE : .:.:: . :::::: ::::::.:::::::.:. .:: .. : . .. .: . CCDS48 KGLDDLDADADDGWAGLHEEVDYSEKLKFSDDEE----EEEVVKDGRPKWNSWDPRRQRQ 360 370 380 390 400 410 380 390 400 410 420 430 pF1KB0 ADGKKGNSPNSEPPTPKTA-WAETSRPPETEPGPPAPKPPLPPPHRGPAGNWGPPGDYPD . ....: ... . :::. .. : :.:: : .: :.: :: CCDS48 LSMSSADSADAKRTREEGKDWAEAVGASRVVRKAPDPQPP-PRKLHG----WAPGPDYQK 420 430 440 450 460 440 450 460 470 480 490 pF1KB0 RG-GPPCKPPAPEDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKL . : . . ::... :.: .::.: ::::::.:::::::: .::: :::: :: CCDS48 SSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKL 470 480 490 500 510 520 500 510 520 530 540 550 pF1KB0 KRLDEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPKELPAPPAPPPASAPTPEKEPEEPA :.::.: : .:. : .: .:. : :.: : . .:: CCDS48 KQLDQKCKQARKAGEARKQAEKEVPWSPSAEKASPQE-----NGPAVHKGSPEF------ 530 540 550 560 570 560 570 580 590 600 610 pF1KB0 QAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPEPPEEVPPPTT ::: ::: :::. ::. : :.: : .:. CCDS48 ---PAQETPTTFPEEAPTV-----------------SPAVAQSNSSE--EEAREA----- 580 590 600 610 620 630 640 650 660 670 pF1KB0 PPVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQHQWQQHQQG :. :.: . :::::::::::::::.: ::.: .:: : CCDS48 ---------GS--------PAQEF---KYQKSLPPRFQRQQQQQ---QQEQLYKMQHWQ- 620 630 640 680 690 700 710 720 730 pF1KB0 SAPPTPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYV : : ::: :: ...:: . : : ..:::::::.: :. CCDS48 --PVYP-PPSHPQ-----------------RTFYP----HHPQM--LGFDPRWMMMPSYM 650 660 670 680 740 750 760 770 780 pF1KB0 DPRLLQGRPPLDFYPPGVHPSGLV----PRERSDSGGSSSEPFDRHAPAMLRERGTPPVD :::. : :.:::: ..:::::. :.: .. : :: :.. :.:: . :.: CCDS48 DPRITPTRTPVDFYPSALHPSGLMKPMMPQESLNGTGCRSE--DQNCVPPLQERKVTPID 690 700 710 720 730 790 800 810 820 830 840 pF1KB0 PKLAWVGDVFTATPAEPRPLTSPLRQAADEDDKGMRSETPPVPPPPPSSSA-----VFR- .: . . : .. :: : . . : .:.:. .... .:. CCDS48 SPPVWSPEGYMALQSKGYPLPHPKSSDTLAMDMRVRNESSFSASLGRAGGVSAQRDLFEE 740 750 760 770 780 790 850 860 870 880 pF1KB0 ----------------LDQVIHSNPAGIQQALAQLSSRQGSVTAPGGHPRHKPGPPQAPQ .:. : :. : :. : . .. ::::: .. : :. CCDS48 RGEEYLSAFDKKAQADFDSCISSQRIG-QELLFPPQENVQDAGAPGGHTQNLRCSPLEPD 800 810 820 830 840 850 890 900 910 920 930 940 pF1KB0 GPSPRPPTRYEPQRVNSGLSSDPHFEEPGPMVRGVGG-TPRDSAGVSPFPPKRRERPPRK : . .:. . .: .: : . ..:: :::.... . . : .. CCDS48 ----FVPDEKKPECGSWDVSHQP---ETADTAHGVERETPREGTAFNISSWDKNGSPNKQ 860 870 880 890 900 910 950 960 970 980 990 1000 pF1KB0 PELLQEESLPPPHSSGFLGSKPEGPGPQAESRDTGTEALTPHIWNRLHTATSRKSYRPSS : . : : :.::. ...:: : ..: .: CCDS48 PSS-EPEWTPEPRSSS--SQHPEQTG---RTRRSGPIKKPVLKALKVEDKEKELEKIKQE 920 930 940 950 960 1010 1020 1030 1040 1050 1060 pF1KB0 MEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRP CCDS48 LGEESTRLAKEKEQSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGREATKFEEEEK 970 980 990 1000 1010 1020 1533 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 11:36:28 2016 done: Thu Nov 3 11:36:29 2016 Total Scan time: 8.320 Total Display time: 0.360 Function used was FASTA [36.3.4 Apr, 2011]